WEL COME

TOPIC-PANCREAS

What are glands ?

Secretory organs of our body.

Two types (i)Exocrine glands

(ii)endocrine glands

PANCREAS -THE DUAL GLAND

LOCATION

PANCREAS

EXOCRINE ENDOCRINE

PAUL LANGERHANS

98% OF TOTAL PANCREAS

IS EXOCRINE

ENDOCRINE SYSTEM

CONSISTS OF ONLY 2% OF

TOTAL PANCREAS.

CELLS OF THE ISLET

OF LANGERHANS

ALFA CELL BETA CELL DELTA CELL F CELL

10-15% 30-40% 5% 3-5%

OXYPHILIC BASOPHILIC ARGYROPHILIC

STAINED RED AS

MALLARY AZAN DYE ORANGE BLUE

WELL DEV. GRANULE MORE PROMINENT SMALL SIZE GRANULES

THAN ALFA CELL GRANULE PRESENT

(GOLGI,ER,FREE (GOLGI,ROUGH ER,

RIBOSOME ETC.) FREE RIBOSOME MORE) (FEW AND SMALL)

SEC. GLUCAGON INSULIN SOMATOSTATIN PANCREATIC

POLYPEPTIDE(PP)

PRODUCTION OF HORMONES

1 BETA CELL INSULIN

C-PEPTIDE

PRO INSULIN

AMYLIN

2 ALFA CELL GLUCAGON

3 DELTA CELL SOMATOSTATIN

MOL.WT=6000 ALKALINE

12000 ACIDIC

A-CHAIN

(21 AMINO

ACID)

B-CHAIN

(30 AMINO

ACID)

+INSULIN

(51 AMINO

ACID)

DISULPHIDE

BRIDGE

SYNTHESIS OF INSULIN

BANTING AND BEST

BIO-FUNCTION OF INSULINTransport & uptake glucose by the cells

Promotes & inhibits glycogenesis

Inhibits gluconeogenesis

Preventing conversion of protein into glucose

Accl. Protein synthesis

Promotes synthesis of fatty acid

Helps in storage of fat in adipose tissue

GLUCAGON

ANY QUESTION ?