Pages 398-403. Two parts: 1.Lymphatic vessels 2.Lymphoid tissues and organs Functions: ◦...
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Transcript of Pages 398-403. Two parts: 1.Lymphatic vessels 2.Lymphoid tissues and organs Functions: ◦...
Pages 398-403
Two parts:1. Lymphatic vessels2. Lymphoid tissues and organs
Functions:◦ Transports escaped fluids back to the blood◦ Body defense and resistance to disease
© 2015 Pearson Education, Inc.
Lymph—excess tissue fluid and plasma proteins carried by lymphatic vessels◦ Also includes cell debris, bacteria, viruses
Lymphatic vessels◦ pick up lymph and return it to the blood
Lymph capillaries (smallest) absorb leaked fluid Contain minivalves to ensure one-way flow to heart
Stay closed when vessel pressure > interstitial fluid Remain open when vessel pressure < interstitial fluid
If fluids are not picked up, edema occurs (fluid accumulates in tissues and the area swells)
© 2015 Pearson Education, Inc.
Venoussystem
Arterialsystem
Lymphaticsystem
Heart
Lymph duct
Lymph trunk
Lymph node
Lymphaticcollectingvessels,with valves
Lymphcapillary
Tissue fluid(becomes
lymph)
Bloodcapillaries
Loose connectivetissue aroundcapillaries
(a)
Tissue fluid
Tissue cell
Lymphaticcapillary
Bloodcapillaries
Arteriole Venule
(b)
Endothelialcell
Fibroblast in looseconnective tissue Flaplike
minivalve
Filamentsanchored toconnectivetissue
Lymph is collected through a system of vessels that gets progressively larger
Two large ducts return fluid to circulatory veins near the heart◦ Right lymphatic duct
drains the lymph from the right arm and the right side of the head and thorax
◦ Thoracic duct drains lymph from rest of body
© 2015 Pearson Education, Inc.
Regionallymph nodes:
Cervicalnodes
Axillarynodes
Inguinalnodes
KEY:
Drained by the right lymphatic ductDrained by the thoracic duct
Entrance of rightlymphatic duct into rightsubclavian vein
Internal jugular vein
Thoracic ductentry into leftsubclavian vein
Thoracic duct
Aorta
Spleen
Cisterna chyli (receiveslymph drainage fromdigestive organs)
Lymphatics
similar to veins of the cardiovascular system◦ (have the same tunics: intima, media, externa)◦ Thin endothelial walls◦ Valves in larger vessels◦ Low-pressure, pumpless system
Lymph transported is aided by:◦ Milking action of skeletal muscles◦ Pulsations of nearby arteries◦ Pressure changes in thorax during breathing◦ Smooth muscle in walls of vessels
© 2015 Pearson Education, Inc.
About 500 nodes in the body◦ Large clusters in specific regions:
inguinal, axillary, cervical
Structure:◦ Surrounded by a dense connective tissue capsule◦ Compartmentalized: sinuses lined with endothelial cells◦ Outer cortex contains lymphocytes (B cells & T cells)◦ Inner medulla contains phagocytic macrophages
filter harmful materials before it is returned to the blood◦ Bacteria◦ Viruses◦ Cancer cells◦ Cell debris
© 2015 Pearson Education, Inc.
Afferentlymphaticvessels
Afferentlymphaticvessels
Germinalcenter infollicle
Efferentlymphaticvessels
Cortex
Follicle
Medullary cord
Medullary sinus
Hilum
Trabecula
Subcapsularsinus
Capsule
Several other organs contribute to lymphatic function:◦ Spleen◦ Thymus◦ Tonsils◦ Peyer’s patches
© 2015 Pearson Education, Inc.
Tonsils (inpharyngeal region)
Thymus (in thorax;most active duringyouth)
Spleen (curvesaround left side ofstomach)
Peyer’s patches(in intestine)
Appendix
left side of the abdomen, beneath diaphragm, around the stomach
Functions:◦ Filters pathogenic debris from blood◦ Destroys worn-out red blood cells
Iron is reused for hemoglobin mfr. Remainder is secreted in bile
Acts as a platelet reservoir Site of hematopoesis in the fetus
© 2015 Pearson Education, Inc.
Located low in the throat, just under the sternum
Function:◦ (at peak levels only during childhood)◦ Produces hormones (such as thymosin)
hormones cause T lymphocytes to gain immunocompetency
© 2015 Pearson Education, Inc.
masses of lymphoid tissue around the pharynx◦ Palatine tonsils are most often infected
Trap and remove bacteria/foreign materials Tonsillitis -caused by congestion with
bacteria
The ability of the tonsils to trap bacteria generates a wide variety of memory lymphocytes that protect throughout life
© 2015 Pearson Education, Inc.
Found in the wall of the small intestine and appendix
Resemble tonsils in structure Capture and destroy bacteria in the
intestine◦ Prevent bacteria from getting into blood here◦ Generate memory lymphocytes for long-term
© 2015 Pearson Education, Inc.
Includes:◦ Peyer’s patches◦ Tonsils◦ Other small accumulations of lymphoid tissue
Acts as a sentinel to protect respiratory and digestive tracts
© 2015 Pearson Education, Inc.