Page 1 of 148 Diabetes...in DM and NL rat CECs. We identified 1888 probe sets with more than...

1

Genome-wide transcriptional analysis of differentially expressed genes in diabetic,

healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression

contributes to the delay of epithelial wound healing in diabetic corneas

Ilham Bettahi1*, Haijing Sun1*, Nan Gao1*, Feng Wang1, Xiaofan Mi1, Weiping Chen2, Zuguo Liu3,

and Fu-Shin Yu1

Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, 48201; 2Genomic Core Lab of National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20855. 3Xiamen Eye Center, Key Laboratory of Ophthalmology and Visual Science of Fujian Province, Xiamen University, Xiamen, Fujian, China

Number of words in Abstract: 198; text: 3996

Number of figures: 8

Number of Tables: 1

References: 50

Correspondence to: Fu-Shin X. Yu, Ph.D., Kresge Eye Institute, Wayne State University

School of Medicine, 4717 St. Antoine Blvd, Detroit, MI, 48201

Tel: (313) 577-1657

Fax: (313) 577-7781

E-mail: [email protected]

*These authors contributed equally to this work.

of 148 Diabetes

1

Diabetes Publish Ahead of Print, published online December 4, 2013

2

ABSTRACT

Patients with diabetes mellitus (DM) may develop corneal complications and delayed wound

healing. The aims of this study are to characterize the molecular signatures and biological

pathways leading to delayed epithelial wound healing and to delineate the involvement of

TGFβ3 therein. Genome-wide cDNA microarray analysis revealed 1888 differentially expressed

genes in the healing epithelia of normal (NL) versus type 1 DM rat corneas. Gene Ontology and

Enrichment analyses indicated TGFβ-signaling as a major altered pathway. Among three TGFβ

isoforms, TGFβ1 and β3 were upregulated in response to wounding in NL corneal epithelial

cells (CECs) whereas the latter was greatly suppressed by hyperglycemia in rat type 1 and 2

and mouse type 1 DM models. Functional analysis indicated that TGFβ3 contributed to wound

healing in NL corneas. Moreover, exogenously-added TGFβ3 accelerated epithelial wound

closure in type 2 rat and type 1 mouse DM corneas via Smad and PI3K-AKT signaling pathways,

auto-regulation, and/or upregulation of a well-known TGFβ target gene, Serpine1. Taken

together, our study for the first time provides a comprehensive list of genes differentially

expressed in the healing CECs of normal versus diabetic corneas and suggests the therapeutic

potential of TGFβ3 for treating corneal and skin wounds in diabetic patients.

Key words: cDNA array, diabetic keratopahty, TGFβ, corneal epithelial wound healing,

differential gene expression

of 148Diabetes

3

Introduction

With the rapid increase in the prevalence of diabetes mellitus (DM), ocular complications

have become a leading cause of blindness around the world. In addition to abnormalities of the

retina (retinopathy) and the lens (cataracts), various types of corneal disorders are also

relatively common in DM patients (1). Hyperglycemia significantly alters epithelial structure and

function, resulting in basal cell degeneration (2), decreased cell proliferation (3; 4), superficial

punctate keratitis (5), breakdown of barrier function, fragility (6; 7), recurrent erosions, and

persistent epithelial defects (8), depending on the duration of DM and on the serum

concentration of glycated hemoglobin HbA1c. The epithelial abnormalities, termed

keratopathy/epitheliopathy, are likely the results of these pathological changes and are resistant

to conventional treatment regimens (9). Hence, a better understanding of the pathogenesis of

diabetic keratopathy should lead to a better management of the disease.

Similar to other mucosal linings, the corneal epithelium is under constant environmental

insults, often resulting in tissue injury. Prompt healing of the injured epithelium is vital to

maintaining a clear, healthy cornea and for preserving vision (10). Healing involves a number of

processes including cell migration, proliferation, differentiation and apoptosis as well as tissue

remodeling (11). Hyperglycemia has profound effects on these biological processes. Unlike

diabetic retinopathy, diabetic keratopathy does not cause many detectable clinical symptoms

unless CECs are removed or an eye is injured (12). Delayed epithelial wound healing may lead

to sight-threatening complications such as stromal opacification, surface irregularity, and

microbial keratitis (9). Hyperglycemia is likely to execute its adverse effects on corneal wound

healing by modifying the expression of a host of wound response genes. To date, a genome-

wide screen for genes, their associated pathways, and the networks affected by DM in CECs in

vivo and their roles in wound closure have not been reported for the cornea.

Recently, we developed/adapted several diabetic models and demonstrated that diabetic

rat corneas exhibited a similar pathology of human diabetic keratopathy including decrease

of 148 Diabetes

4

corneal sensitivity, reduced tear secretion, and most importantly, delayed epithelial wound

healing, indicating that these are useful models to study impaired wound healing in diabetic

corneas (4; 6; 7). In this study, we took advantage of an easily procurable epithelial cell

population during epithelial debridement and from migrating epithelial sheets that have moved

into the original wound bed. Using genome-wide cDNA microarray, we profiled gene expression

in DM and NL rat CECs. We identified 1888 probe sets with more than 1.5-fold changes in the

healing CECs of DM compared to NL corneas, and found TGFβ signaling as a major pathway

affected by hyperglycemia in DM CECs. We further demonstrated for the first time that wound-

induced upregulation of TGFβ3 is dampened by hyperglycemia and exogenously-added

TGFβ3-accelerated delayed epithelial wound closure in three rodent diabetic models. We

proposed that TGFβ3 is a suitable therapeutic for treating delayed diabetic wound healing in

peripheral tissues such as the cornea and skin.

of 148Diabetes

5

RESEARCH DESIGN AND METHODS

Animals and Induction of Diabetes

All investigations conformed to the regulations of the ARVO Statement for the Use of Animals in

Ophthalmic and Vision Research, the National Institutes of Health. Streptozotocin (STZ)

induction of type 1 DM Sprague-Dawley (SD) rats was as described (4; 7) and type 2 Goto-

Kakizaki (GK) rats were maintained in KEI animal facility under standard conditions. C57BL/6

mice were induced to develop type 1 DM according a Low-Dose STZ Induction Protocol

(mouse). Glucose levels and body weight were monitored weekly. Animals with blood sugar

levels higher than 400 mg/dL (STZ-SD rats), 220 mg/dL (GK), and 350 mg/dL were considered

diabetic and were used, with age-matched animals as the control, at 8 weeks post STZ

treatment for SD rats, 6 months old for GK rats, 10 week post STZ for B6 mice. These are times

when epithelial wound closure was significantly delayed and many pathologies can be observed

in the DM animals (6; 7; 13).

Corneal Epithelial Debridement Wound

Anesthetized rats and mice were first demarcated with a trephine in the central cornea

(5-mm circular wound for rats and 2 mm for mice) and CECs were removed with a blunt scalpel

blade under a dissecting microscope (4; 6; 7). The blade with scrapped CECs was immediately

immersed into liquid nitrogen and the visible ice was collected into a test tube, placed on dry ice

and stored at−80 ◦C. The sample was marked as unwounded (UW). Bacitracin ophthalmic

ointment was applied to the cornea after surgery to prevent infection. At 42 hours (rats) or 24 h

(mice) post wounding (hpw.), the same size trephine was used to mark the original wound, and

CECs within the circle were removed, collected as described for the original wounding, and

marked as healing CECs.

RNA extraction and Real-time PCR.

of 148 Diabetes

6

For RNA isolation, CECs were scraped off of corneas, with 2 corneas pooled into 1 tube

as one sample. RNA was extracted from the collected CECs using RNeasy Mini Kit (QIAGEN).

cDNA was generated with an oligo(dT) primer (Invitrogen) followed by analysis using real-time

PCR with the Power SYBR Green PCR Master Mix (AB Applied Biosystems), based on the

expression of β-actin.

Gene array and functional analysis

cDNAs were synthesized and hybridized to Affymetrix GeneChip Rat Genome 230. 2.0

array was performed by the Microarray Core Facility at WSU according to the manufacturer’s

protocols. The microarray data were evaluated by the Genomic Core Lab of National Institute of

Diabetes and Digestive and Kidney Diseases. The ANOVA analysis for the RMA normalized

data sets was completed by the commercial microarray data analysis software Partek Genomic

Suite http://www.partek.com/partekgs/. Signaling pathway and functional network analyses were

performed using Genomatrix Pathways System software.

Subconjunctival injection of siRNA and recombinant TGFβ polypeptides.

For mice, 5µl of solution were injected into the subconjunctival space at 1 site at the superior

part of the cornea and for rats, 20µl at 2 sites, 10µl each at the superior and inferior quadrants.

TGFβ3 was injected 4-6h and siRNA 24h prior to wounding.

Immunohistochemistry of rat, mouse and human corneas.

Rat eyes were enucleated and embedded in Tissue-Tek OCT compound, and frozen in liquid

nitrogen. Six micrometer-thick sections were cut and mounted to polylysine-coated glass slides.

Normal and diseased human corneas obtained from the Midwest Eye Bank were embedded in

Tissue-Tek OCT compound immediately upon arrival. The cryostat sections of wounded and

of 148Diabetes

7

healed organ-cultured human corneas of diabetic and age-controlled groups were a gift from

Dr. Alexander V. Ljubimov, Cedars-Sinai Medical Center (2). After air dry, followed by a 10-min

fixation in 4% paraformaldehyde, slides were blocked with 2% BSA in PBS for 1 hour at RT.

Sections were then incubated with rabbit primary antibody (TGFβ1, TGFβ2 and TGFβ3 1/50,

AbCam). This was followed by FITC anti-rabbit antibody (Jackson ImmunoResearch

Laboratories 1:100). Slides were mounted with Vectashield mounting medium containing DAPI,

and examined under a Carl Zeiss fluorescence microscope Axioplan 2 equipped with an

ApoTome digital camera or using confocal microscopy (TCSSP2; Leica). Controls were similarly

treated, but the primary antibody was replaced with rat or rabbit IgG.

Determination of Protein Expression and phosphorylation by Western Blot Analysis

The epithelial cells removed during corneal debridement (the control) and pw, but prior to wound

closure, were collected from normal and diabetic rat corneas and lysed with RIPA buffer. Protein

concentrations were determined using Micro BCA kit. Levels of various proteins or their

phosphorylation were determined using specific antibodies. For each condition, two samples

were shown with β-actin levels as the internal controls.

Statistical analysis

Data were presented as means ± standard error. Statistical differences among three or more

groups were first identified using one way analysis of variance (ANOVA), followed by Student's

t-test for pairwise comparison. Differences were considered statistically significant at p < 0.05.

of 148 Diabetes

8

RESULTS

We previously showed that epithelial wound healing, as seen in DM patients, was

significantly delayed in the corneas of STZ-induced type 1 and GK type 2 diabetic rats

compared with the control rats (4; 7; 13; 14). We reasoned that genes induced in response to

wounding and affected by hyperglycemia are responsible for the delay of epithelial wound

closure in the cornea and we performed a genome-wide microarray expression analysis to

compare the gene expression profiles of CECs collected during the creation of epithelial

debridement wounds (0h) and 42 hpw (42h) from the control, non-diabetic (NL) and from the

diabetic (DM) rat corneas (Fig.1A). The rats used were 14 weeks old with 8 weeks of

hyperglycemia, the duration sufficient to affect the rate of epithelial wound closure. Using Rat

Genome GeneChip, we detected 5426 probe sets differentially expressed at least in one of 4

paired comparisons (Fig.1B). When healing was compared to UW CECs, a 2.0 fold change

cutoff was used, resulting in more than 3000 probe sets differentially expressed in NL and DM

corneas. When DM CECs were compared to NL CECs, a 1.5 fold change cutoff was used as a

much small number of differentially expressed genes were detected: 772 (397 increase and 377

decrease) in UW CECs and 1888 probe sets (636 increase and 1253 decrease) in healing

CECs. Supplemental Table 1 listed all differentially expressed genes (probe sets). Table 1 listed

the top 10 most up- or down-regulated genes in 4 paired comparisons:

Pair 1: Healing versus UW CECs in NL corneas.

The most elevated gene is S100A9 (705 fold) which is known to form a heterodimer with

S100A8 (249 fold increase), both of which are highly inducible genes in epithelial cells (15). Its

deficiency was found to be associated with non-healing venous leg ulcers (16). Prominent

among greatly down-regulated genes is CXCL14, a homeostatic chemokine that is expressed in

basal epidermal keratinocytes (17; 18). The expression patterns of S100A9 and CXCL14 were

verified by realtime-PCR (Fig.2A and B).

Pair 2: Healing versus UW CECs in DM corneas.

of 148Diabetes

9

Compared to NL, the healing CECs of DM corneas had 288 more probe sets differentially

expressed, and 2497 probe sets showed altered expression in both NL and DM CECs. Among

the10 most highly upregulated genes, 9 were also found in DM corneas with comparable fold

changes. Tenascin C (Tnc) was replaced by podoplanin (Pdpn), a marker of lung injury (19), in

DM CECs. On the down-regulated gene list, Wnt2 was worthy of mention as it was not

expressed in UW CEC. The down regulation of Wnt2 in DM, compared to NL healing CECs

was verified by realtime-PCR (Fig.2C).

Pair 3: DM versus NL UW CECs.

Compared to healing versus UW CECs in pairs 1 and 2, there were fewer differentially

expressed genes in DM versus NL CECs, with much lower-fold changes. Thus, we lowered the

cutoff value to 1.5 fold changes. The most highly upregulated and downregulated genes were

Ephx2, known to contribute to renal injury during diabetes (20), and C1ql3, a gene only found in

the central nerve system to regulate synapse formation (21), respectively. Upregulation of

Ephx2 in DM CECs was verified by realtime-PCR (Fig.2D)

Pair 4: Diabetic versus non-diabetic healing CECs.

Compared to homeostatic cells, a relatively large number of genes were found to be

differentially expressed: 1888 probe sets in DM versus NL healing CECs. Among the 105 highly

induced probe sets, only 17 probe sets represent known genes, including Ephx2. On the other

hand, many probe sets with down-regulated expression in DM, compared to in NL healing

CECs, contained gene identities. These include Vimentin, ATF3, Wnt2, Tenascin C, peroxidasin

(a gene associated with anterior segment dysgenesis (22)) and MMP12. Figure 2E and 2F

show the verifications of the expression patterns of Vimentin and MMP12.

Among the total of 56 genes listed in Table 1, the expression patterns of 17 genes were

confirmed in 1 or more DM models by realtime-PCR and/or immunohistochemistry.

of 148 Diabetes

10

Decreased expression of TGFβ3 in healing CECs of diabetic corneas.

GO analysis of 1888 probe sets revealed many signaling pathways altered including IL-1

(1.02e-3, 22/132, also see Fig.3), HGF (2.8e-314/75), MMP (1.58e-4, 23/124) and TGFβ (7.39e-

3, 43/360) mediated pathways. Similar to GO Analysis, enrichment analysis of genes

differentially expressed in DM versus NL healing CECs revealed TGFβ-dependent epithelial-

mesenchymal transition to be a major event altered therein. Hence, we focused on TGFβ

signaling pathways.

To assess the expression patterns of the TGFβ family, RT PCRs was performed (Fig.3A)

using STZ SD rats. All three isoforms were detected while mRNA for IL-1β (as a control) was

undetectable in UW NL and DM CECs. Wounding induced Il-1β expression at the mRNA levels

and this upregulation was more apparent in diabetic healing CECs. The levels of TGFβ1 were

also elevated in healing CECs; however, there was no detectable difference between DM and

NL corneas (Fig.3B). The levels of TGFβ2 were consistent under 4 conditions. TGFβ3, on the

other hand, was greatly upregulated in the healing CECs of NL, but the levels of TGFβ3 in DM

CECs remained at a level comparable to that of UW CECs. We have established 3 rodent

diabetic models: STZ SD rats (4; 7), GK rats (6), and STZ-B6 mice. The expression of TGFβ3

was further assessed by real time PCR which showed significant upregulation in the healing

CECs of NL, but not DM, corneas in all 3 rodent models (Fig.3B-D).

The expression and distribution of TGFβ3 in were also assessed using

immunohistochemistry (Fig.4). While TGFβ3 abundantly stained the entire healing corneal

epithelial sheet, from the leading edge to the border region between the cornea and limbus in

SD rat corneas, there were only a few TGFβ3 positive cells found at the leading edge of the

migratory epithelial sheet in type 1 DM rat corneas; the rest of the epithelial sheet stained low or

negative.

TGFβ3 is necessary for proper wound healing.

of 148Diabetes

11

We next investigated whether TGFβ3 is required for wound healing in NL rats. We used

subconjunctival injection of siRNA in Wistar rats and observed a significant delay in TGFβ-

specific, but not the control siRNAs, compared to the control rats (Fig.5A). Western blotting

analysis of CECs revealed a basal expression of TGFβ3 in unwounded CECs and elevated

levels in healing CECs in the Wistar rat and this wounding-induced TGFβ3 upregulation was

knocked down by TGFβ3 specific siRNA. In UW CECs, there was no detectable

phosphorylation of Smad2/3 and AKT, and in healing CECs, both signaling molecules were

phosphorylated. Consistent with downregulated TGFβ3 levels, the phosphorylation of these

proteins was also dampened, while the expression of ATF3, a stress responsive transcription

factor with a similar expression pattern to TGFβ3 (Table 1), was not affected (Fig.5B).

Exogenous TGFβ3 accelerates delayed epithelial wound closure in DM corneas.

Whether exogenously-added TGFβ3 in diabetic corneas accelerates delayed epithelial wound

closure in GK and STZ B6 mice was assessed next. In GK rat corneas, 40 ng TGFβ3 in 20µl

was injected 4 h prior to epithelial debridement; this substantially increasing the rate of wound

closure (Fig.6A and B) and enhancing Smad2/3 phosphorylation in healing CECs (Fig.6C). To

assess if exogenously added TGFβ3 affects the isoform expression, antibodies against TGFβ1-

3 were used for Western blotting. While TGFβ1 was up-regulated in healing DM CECs,

exogenously-added TGFβ3 appeared to have no effects on its expression. The levels of β2

were low and unchanged in all the samples. Interestingly, exogenously-applied TGFβ3

increased TGFβ3 expression. While some elevated active TGFβ3 molecules could be from

exogenously added TGFβ3 (15 kDa), the latent form (47 kDa) can only be from endogenous

sources, indicating an autoregulation of TGFβ3 expression in rat corneas.

In STZ B6 mice, the addition of TGFβ significantly increased the rate of epithelial closure

at 16 and 24 hpw (Fig.7A and B). Using Serpine1, a common target of TGFβ (23) as an

of 148 Diabetes

12

example, our data showed that its mRNA levels were correlated to the levels of TGFβ3 activity

and to that of the rates of wound closure in NL and DM mice (Fig.7C).

TGFβ3 expression in cultured human UW and post-wounding corneas

Delayed epithelial wound healing has also been shown in organ-cultured human corneas (2).

We obtained NL and DM corneal cryostat sections without (direct embedded in OCT) or with

epithelial wounding, which were allowed to heal in an organ culture setting (2), and assessed

TGFβ3 expression in these corneas using confocal microscopy (Fig.8). In unwounded corneas,

there were detectable levels of TGFβ3 in the epithelial layer. In the p.w. cornea with healed

epithelial wound (2), all cell layers were positive with a strong TGFβ3 immunoreactivity in NL

corneas, while weak staining was detected in DM CECs.

of 148Diabetes

13

DISCUSSION

In this study we used genome-wide cDNA microarrays to compare the gene expression

profiles of healing versus UW and DM versus NL CECs. Our results revealed that wounding

dramatically altered the expression of a large number of genes in both NL and DM corneas.

Bioinformatics revealed many TGFβ-mediated signaling pathways and biological processes

were altered. Using three diabetic mouse and rat models, we showed that TGFβ3 activity is

required for proper wound healing in non-diabetic corneas while exogenously added TGFβ3

promotes epithelial wound healing in the corneas of type 1 DM rats and mice and type 2 DM

rats. The effects of TGFβs on epithelial wound closure are related to its ability to activate

Smad-dependent and -independent pathways, to modulate its own expression, and to mediate

target gene expression. Taken together, our study suggests that the hyperglycemia-suppressed

genes such as TGFβ3 and Serpine1 might be used as therapeutic reagents to accelerate

delayed epithelial wound healing in diabetic corneas.

The genome-wide cDNA array analyses revealed a greatly altered expression of genes

in response to wounding and illustrated genes affected by hyperglycemia at a much larger scale

in CECs. Unlike previous studies using limited arrays and RNA isolated from the cornea (24;

25), our approach used CECs and thus avoided false positive results from infiltration of immune

cells in the stroma. Although the majority of the genes detected with differential expression are

likely from epithelial cells, a small portion of differentially expressed genes might be from

dendritic cells, as they migrate with the healing epithelial sheets (26). Moreover, 8 weeks of

hyperglycemia represented an early stage of DM when a significant delay of epithelial wound

closure begun (4; 7). This allows us to characterize early events of diabetic complication, which

can be effectively intervened with or even reversed. With these advantages, our genome-wide

cDNA array revealed a large number of genes (probe sets) differentially expressed and the

expression of many genes were verified by other means and/or consistent with their known

function, further validating the value of the genome-wide microarray data.

of 148 Diabetes

14

Comparison of healing DM with healing NL CECs revealed that 1888 probe sets had

altered expression. Intriguingly, of the 36 probe sets with more than 3-fold increases in DM

healing versus NL healing, only 4 are identified genes; the rest were derived from DNA

sequence tags without gene identities. Among 4 genes, the up-regulation of Ephx2, which has

been linked to subclinical cardiovascular disease in the Diabetes Heart Study (27), is most

interesting as it was shown to increase manifestations of diabetic nephropathy in mice (20).

There were 17 genes with 4-fold decreases and among them, ATF3 and CEACAM1 have been

shown to be associated with DM (28; 29). The role of Ephx2, ATF3, and Ceacam1 or the lack

thereof in diabetic corneas remains to be determined.

GO analyses revealed that the TGFβ-Smad mediated signaling pathway was impaired in

DM healing CECs. Since TGFβ has been known to play a key role in corneal wound healing

and fibrosis and the major cellular source of TGF-beta in corneal wounds is the epithelium (30),

we assessed the expression of 3 TGFβ isoforms and observed that hyperglycemia had no

effects on TGFβ1, but greatly suppressed TGFβ3 in diabetic healing CECs. In the cornea,

earlier studies reported that both TGFβ1 and β2 are seen within the corneal epithelium and

stroma in the injured cornea while TGFβ3 is not found in the anterior eye (for review see (31)).

More recent studies reported that TGFβ3 was found in the basal cells of regenerating areas as

well as in uninjured regions of the cornea after corneal injury (32). We presented strong

evidence of up-regulation of TGFβ3 expression in three animal models as well as in cultured

human corneas. Hence, we conclude that TGFβ3 is expressed in CECs and its expression is

up-regulated in response to wounding in NL corneas. More strikingly, we showed almost total

suppression of wound-induced TGFβ3 upregulation in diabetic corneas, suggesting a unique

role of TGFβ3 in mediating epithelial wound closure. To our knowledge, our study is the first to

unambiguously demonstrate the suppressive effects of hyperglycemia on the expression of

TGFβ3, but not TGFβ1, at both mRNA and protein levels, in response to wounding.

of 148Diabetes

15

Although TGFβ1-3 share 60–80% identity, they are encoded by distinct genes, have

different sequences in promoters, and exhibit different physiological and pathological activities

in vivo (33). The importance of TGFβ in maintaining tissue homeostasis and in regulating

wound healing in the cornea has been reported (for review see (31)). TGF-β’s response to

wounding can be mediated through Smad-dependent and independent signaling pathways in a

cell type– and context-dependent manner (34-37). Among Smad-independent pathways, the

PI3K/AKT pathway plays a significant role in regulating TGFβ-mediated responses (35).

Demonstration that wound-induced TGFβ3 expression in CECs is sensitive to hyperglycemia

suggests a distinctive regulation and a unique role of the isoform in modulating epithelial wound

healing.

To define the role of identified genes, we administrated siRNA or recombinant TGFβ3 to

the corneas using subconjunctival injection, which is a common procedure performed at

Ophthalmologists’ office to deliver drugs to treat corneal diseases and glaucoma, and has been

shown to allow bevacizumab to penetrate intact cornea (38-40). Using subconjunctival injection

to deliver TGFβ3 siRNA in NL corneas and recombinant TGFβ3 in NL and DM corneas, we

demonstrated that TGFβ3 upregulation in response to epithelial wounding contributes to

epithelial wound healing and activates both canonical and non-canonical signaling pathways.

The altered expression of TGFβ3 was also confirmed in cultured human corneas post wound

healing, indicating the relevance of the study. Moreover, we demonstrated that exogenous

TGFβ3 partially restored the healing rate of epithelial wounds in diabetic corneas of three rodent

models, suggesting an important role for the isoform in mediating epithelial response to injury.

Strikingly, we discovered that exogenously applied TGFβ3 elevated the levels of latent TGFβ3,

but not TGFβ1 or β2, at the protein levels, suggesting an auto-regulated expression of TGFβ3 in

the healing CECs, such as that observed in the mouse skin carcinogenesis model (41). While

the mechanisms underlying hyperglycemia-suppressed wound-induced TGFβ3 expression is

unclear, early inhibitory effects of hyperglycemia on TGFβ3 expression, which differs from that

of 148 Diabetes

16

of TGFβ1 (42), may exacerbate the suppression of TGFβ3 upregulation in response to

wounding. Finally, we showed that the expression of Serpine1, a well-known TGFβ target gene

(43; 44), is correlated to the activity of TGFβ3 in healing CECs of both NL and DM corneas.

The discovery that TGFβ has a unique role in mediating corneal epithelial wound healing

is of great significance since 1) the major cellular source of TGFβ in corneal wounds is the

epithelium (30); 2) TGFβ3, in contrast to TGFβ1, is considered an anti-fibrotic (45); 3) TGFβ3

halts fibroblast migration and selectively promotes re-epithelialization in the skin wounds (46),

indicating a critical role in skin wound healing; and 4) recombinant TGFβ3 has been undergoing

phase 3 clinical trials as an anti-scarring agent for adult skin wounds (45; 47; 48). The trial was

considered a failure due to increased angiogenesis in post-surgery skin (45). However, unlike

the pathogenesis of diabetic retinopathy, nephropathy, and atherosclerotic plaque where there

is excessive angiogenesis, blood vessel growth is impaired in diabetic wound healing (49).

Hence, although TGFβ3 may potentially be used as a useful therapy to treat delayed wound

healing in the cornea and in the skin for the benefit of accelerating wound healing and reducing

inflammation that should outweigh adverse effects caused by neovascularization, which may not

occur during diabetic wound healing (49). Further study of the mechanism of the action and

target gene expression of TGFβ3 in the corneal and skin may lead to clinical trials of TGFβ3 for

its unique function in epithelial cells under hyperglycemia conditions.

of 148Diabetes

17

Table 1. Top up- and down-regulated genes The top 10 most up- and down-regulated genes in healing:unwounded CECs of NL rats Gene Symbol Gene Title p-value

Fold-Change

S100a9* S100 calcium binding protein A9 1.64E-10 705.415

Serpinb2* serine (or cysteine) peptidase inhibitor, clade B, member 2 2.14E-10 563.839

Defb4* defensin beta 4 1.03E-09 372.452

Car12* Carbonic anyhydrase 12 1.02E-11 316.135

Serpinb10* Serine/cysteine) peptidase inhibitor, clade B, member 10 2.38E-11 305.695

AVLV472 similar to AVLV472 1.45E-10 272.388

Tnc* Tenascin C 5.27E-08 266.987


Krt17* keratin 17 2.20E-11 202.958

Sprr1b small proline-rich protein 1B (cornifin) 1.23E-06 202.042

Tril TLR4 interactor with leucine-rich repeats 7.17E-07 -27.792

Dync1i1 dynein cytoplasmic 1 intermediate chain 1 4.65E-11 -30.563

Igfbp5 insulin-like growth factor binding protein 5 5.81E-08 -32.459

Lrrn3 leucine rich repeat neuronal 3 1.48E-07 -34.154

Gpm6a glycoprotein m6a 0.000105 -35.599

Cps1 Carbamoyl-phosphate synthetase 1 9.37E-07 -41.316

Gad1 glutamate decarboxylase 1 2.44E-08 -41.548

Tacr2 tachykinin receptor 2 4.29E-07 -42.053

Cxcl14* chemokine (C-X-C motif) ligand 14 1.54E-08 -45.971

Ptpro* protein tyrosine phosphatase, receptor type, O 1.38E-08 -56.52

The top 10 most up- and down-regulated genes in healing:unwounded CECs of DM rats


Serpinb10* serine peptidase inhibitor, clade B, member 10 2.32E-11 311.583

Car12* Carbonic anyhydrase 12 1.25E-11 273.911

Defb4* defensin beta 4 1.85E-09 243.856

Krt17* keratin 17 1.99E-11 217.086

Sprr1b small proline-rich protein 1B (cornifin) 1.24E-06 201.148


AVLV472 similar to AVLV472 3.03E-10 165.464

Serpinb2* serine (or cysteine) peptidase inhibitor, clade B, member 2 1.87E-09 124.377

Pdpn* podoplanin 6.71E-10 122.676

Igfbp5 insulin-like growth factor binding protein 5 1.50E-07 -21.836

Wnt2* Wingless-type MMTV integration site family member 2 0.000251 -21.992

Dapl1 death associated protein-like 1 1.34E-06 -23.277


Tacr2 tachykinin receptor 2 9.35E-07 -29.366

Cxcl14* chemokine (C-X-C motif) ligand 14 3.88E-08 -30.087

Dync1i1 dynein cytoplasmic 1 intermediate chain 1 4.02E-11 -32.555

of 148 Diabetes

18

Gad1 glutamate decarboxylase 1 3.71E-08 -34.251

Cps1 Carbamoyl-phosphate synthetase 1 7.29E-07 -46.747

Ptpro* protein tyrosine phosphatase, receptor type, O 1.63E-08 -51.929

The top 10 most up- and down-regulated genes in unwounded DM:NL rat CECs

Ephx2* epoxide hydrolase 2, cytoplasmic 4.45E-08 14.8351

Akr1b8 aldo-keto reductase family 1, member B8 0.033642 3.35444

Elovl4 Elongation of very long chain fatty acids-like 4 0.030089 3.18504

Ctdspl CTD (carboxy-terminal domain) small phosphatase-like 0.013859 2.89265

Pdyn* prodynorphin 0.024604 2.88355

Col12a1 collagen, type XII, alpha 1 0.047762 2.69369

CAMK1D similar to calcium/calmodulin-dependent protein kinase 1D 0.000102 2.66033

Lect1 leukocyte cell derived chemotaxin 1 0.000163 2.50341

Phb2 Prohibitin 2 0.014843 2.42591

Ddah1 dimethylarginine dimethylaminohydrolase 1 0.004703 2.34997

Ggt1 gamma-glutamyltransferase 1 0.023773 -3.1326

Mtmr1 Myotubularin related protein 1 0.003785 -3.3812

GBP6 similar to guanylate binding protein family, member 6 0.002009 -3.3911

Aqp2 aquaporin 2 (collecting duct) 0.025883 -3.777

Krt8 keratin 8 0.000127 -3.7889

Wfdc5 WAP four-disulfide core domain 5 0.002422 -4.4483


SNX10 sorting nexin 10 2.27E-05 -5.5743

Fam111a family with sequence similarity 111, member A 0.037558 -8.8546

C1ql3* complement component 1, q subcomponent-like 3 2.65E-06 -10.238

The top 10 most up- and down-regulated genes in healing DM:NL rat CECs

Ephx2* epoxide hydrolase 2, cytoplasmic 8.65E-08 11.9119

CD99l2 Similar to MIC2 like 1 0.001322 3.57749

Arid2 AT rich interactive domain 2 (Arid-rfx like) 0.007696 3.03913

Ctdspl CTD (carboxy-terminal domain) small phosphatase-like 0.020035 2.66501

Gsta4 glutathione S-transferase alpha 4 0.005536 2.57045

Phgdh phosphoglycerate dehydrogenase 0.000145 2.50389

Ahdc1 AT hook, DNA binding motif, containing 1 [Rattus 0.002914 2.46515

Phb2 Prohibitin 2 0.016485 2.37832

CD99L2 similar to MIC2 like 1 0.003917 2.26117

Auts2l autism susceptibility candidate 2-like 0.007632 2.24651

Wnt2* Wingless-type MMTV integration site family member 2 0.019534 -4.2398

Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 2.67E-06 -4.2793

Adm* adrenomedullin 0.007971 -4.5972

Fam3b* family with sequence similarity 3, member B 0.000102 -5.1147

Postn periostin, osteoblast specific factor 0.002689 -5.4259

Ceacam1* carcinoembryonic antigen-related cell adhesion molecule 1 0.010465 -6.4485

of 148Diabetes

19

Cald1 caldesmon 1 0.002262 -6.7921

Tmem35 transmembrane protein 35 0.000227 -7.5325

Atf3* activating transcription factor 3 0.006267 -7.5617

Vim* vimentin 0.000222 -8.6761 *the expression pattern the genes was confirmed at least by realtime-PCR in 1 or more animal

DM models.

of 148 Diabetes

20

# Current address:

Department of Ophthalmology, the First Affiliated Hospital of Anhui Medical University, Hefei,

Anhui 230022, PR China

Contribution statement I.B.; N.G.; H.J. performed laboratory testing and edited and checked

accuracy of the manuscript. F.W. performed RNA preparation for microarray and part of

immunohistochemistry. X.M. performed laboratory testing and data analysis. W.C. performed

bioinformatics analysis of cDNA array. Z.L. contributed to discussion, reviewed manuscript.

F.Y. was responsible for study design and recruitment, contributed to sample collection and

data analysis, and reviewed and edited the manuscript. F. Y. is the guarantor of this work and,

as such, had full access to all of the data in the study and takes responsibility for the integrity of

the data and the accuracy of the data analysis.

Acknowledgments: Fu-Shin X. Yu is the guarantor of this manuscript. The authors thank Drs.

Ashok Kumar, Jia Yin, and Patrick Lee of Wayne State University School of Medicine for critical

reading of the manuscript. The authors express their gratitude to Dr. Alexander V Ljubimov,

Regenerative Medicine Institute Cedars-Sinai Medical Center, for providing human corneal

cryostat sections. We acknowledge support from NIH/NEI R01EY10869, EY17960 (to FSY),

p30 EY04078 (NEI core to WSU), Research to Prevent Blindness (to Kresge Eye Institute).

Duality of interest. The authors declare that there is no duality of interest associated with this

manuscript.

of 148Diabetes

21

References

1. Kaji Y: Prevention of diabetic keratopathy. Br J Ophthalmol 2005;89:254-255

2. Kabosova A, Kramerov AA, Aoki AM, Murphy G, Zieske JD, Ljubimov AV: Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture. Exp Eye Res 2003;77:211-217

3. Zagon IS, Sassani JW, McLaughlin PJ: Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats. Diabetes 2006;55:1141-1147

4. Xu K, Yu FS: Impaired Epithelial Wound Healing and EGFR Signaling Pathways in the Corneas of Diabetic Rats. Invest Ophthalmol Vis Sci 2011;

5. Inoue A, Watanabe T, Tominaga K, Tsugawa K, Nishio K, Takahashi KP, Kaneda K: Association of hnRNP S1 proteins with vimentin intermediate filaments in migrating cells. Journal of cell science 2005;118:2303-2311

6. Wang F, Gao N, Yin J, Yu FS: Reduced innervation and delayed re-innervation after epithelial wounding in type 2 diabetic Goto-Kakizaki rats. The American journal of pathology 2012;181:2058-2066

7. Yin J, Huang J, Chen C, Gao N, Wang F, Yu FS: Corneal complications in streptozocin-induced type I diabetic rats. Invest Ophthalmol Vis Sci 2011;52:6589-6596

8. Schultz RO, Van Horn DL, Peters MA, Klewin KM, Schutten WH: Diabetic keratopathy. Trans Am Ophthalmol Soc 1981;79:180-199

9. Pflugfelder SC: Is autologous serum a tonic for the ailing corneal epithelium? Am J Ophthalmol 2006;142:316-317

10. Chi C, Trinkaus-Randall V: New insights in wound response and repair of epithelium. Journal of cellular physiology 2013;228:925-929

11. Martin P: Wound healing--aiming for perfect skin regeneration. Science 1997;276:75-81

12. Bikbova G, Oshitari T, Tawada A, Yamamoto S: Corneal changes in diabetes mellitus. Current diabetes reviews 2012;8:294-302

13. Xu KP, Li Y, Ljubimov AV, Yu FS: High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing. Diabetes 2009;58:1077-1085

14. Wang F, Song YL, Li DH, Li CX, Wang Y, Zhang N, Wang BG: Type 2 diabetes mellitus impairs bone healing of dental implants in GK rats. Diabetes research and clinical practice 2010;88:e7-9

15. Gao N, Sang Yoon G, Liu X, Mi X, Chen W, Standiford TJ, Yu FS: Genome-wide transcriptional analysis of differentially expressed genes in flagellin-pretreated mouse corneal epithelial cells in response to Pseudomonas aeruginosa: involvement of S100A8/A9. Mucosal immunology 2013;

16. Trostrup H, Lundquist R, Christensen LH, Jorgensen LN, Karlsmark T, Haab BB, Agren MS: S100A8/A9 deficiency in nonhealing venous leg ulcers uncovered by multiplexed antibody microarray profiling. The British journal of dermatology 2011;165:292-301

17. Schaerli P, Willimann K, Ebert LM, Walz A, Moser B: Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation. Immunity 2005;23:331-342

of 148 Diabetes

22

18. Meuter S, Moser B: Constitutive expression of CXCL14 in healthy human and murine epithelial tissues. Cytokine 2008;44:248-255

19. Navarro A, Perez RE, Rezaiekhaligh MH, Mabry SM, Ekekezie, II: Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42. American journal of physiology Lung cellular and molecular physiology 2011;300:L32-42

20. Elmarakby AA, Faulkner J, Al-Shabrawey M, Wang MH, Maddipati KR, Imig JD: Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. American journal of physiology Regulatory, integrative and comparative physiology 2011;301:R1307-1317

21. Bolliger MF, Martinelli DC, Sudhof TC: The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proceedings of the National Academy of Sciences of the United States of America 2011;108:2534-2539

22. Khan K, Rudkin A, Parry DA, Burdon KP, McKibbin M, Logan CV, Abdelhamed ZI, Muecke JS, Fernandez-Fuentes N, Laurie KJ, Shires M, Fogarty R, Carr IM, Poulter JA, Morgan JE, Mohamed MD, Jafri H, Raashid Y, Meng N, Piseth H, Toomes C, Casson RJ, Taylor GR, Hammerton M, Sheridan E, Johnson CA, Inglehearn CF, Craig JE, Ali M: Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma. American journal of human genetics 2011;89:464-473

23. Kang Y, Chen CR, Massague J: A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Molecular cell 2003;11:915-926

24. Cao Z, Wu HK, Bruce A, Wollenberg K, Panjwani N: Detection of differentially expressed genes in healing mouse corneas, using cDNA microarrays. Investigative ophthalmology & visual science 2002;43:2897-2904

25. Varela JC, Goldstein MH, Baker HV, Schultz GS: Microarray analysis of gene expression patterns during healing of rat corneas after excimer laser photorefractive keratectomy. Investigative ophthalmology & visual science 2002;43:1772-1782

26. Gao N, Yin J, Yoon GS, Mi QS, Yu FS: Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair. The American journal of pathology 2011;179:2243-2253

27. Burdon KP, Lehtinen AB, Langefeld CD, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW: Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2008;5:128-134

28. Kim JY, Lee SH, Song EH, Park YM, Lim JY, Kim DJ, Choi KH, Park SI, Gao B, Kim WH: A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: controlled by ATF3. Cell Signal 2009;21:1758-1767

29. Najjar SM: Regulation of insulin action by CEACAM1. Trends in endocrinology and metabolism: TEM 2002;13:240-245

30. Stramer BM, Austin JS, Roberts AB, Fini ME: Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. Journal of cellular physiology 2005;203:226-232

31. Tandon A, Tovey JC, Sharma A, Gupta R, Mohan RR: Role of transforming growth factor Beta in corneal function, biology and pathology. Current molecular medicine 2010;10:565-578

of 148Diabetes

23

32. Huh MI, Chang Y, Jung JC: Temporal and spatial distribution of TGF-beta isoforms and signaling intermediates in corneal regenerative wound repair. Histology and histopathology 2009;24:1405-1416

33. Saika S: TGFbeta pathobiology in the eye. Lab Invest 2006;86:106-115

34. Goc A, Choudhary M, Byzova TV, Somanath PR: TGFbeta- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). Journal of cellular physiology 2011;226:3004-3013

35. Hong M, Wilkes MC, Penheiter SG, Gupta SK, Edens M, Leof EB: Non-Smad Transforming Growth Factor-β Signaling Regulated by Focal Adhesion Kinase Binding the p85 Subunit of Phosphatidylinositol 3-Kinase. Journal of Biological Chemistry 2011;286:17841-17850

36. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG: Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells. The Journal of Immunology 2010;184:4295-4306

37. Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas CJ, Patnaik S, Marugan JJ, Judge DP, Dietz HC: Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice. Science 2011;332:358-361

38. Chong RS, Su DH, Tsai A, Jiang Y, Htoon HM, Lamoureux EL, Aung T, Wong TT: Patient acceptance and attitude toward an alternative method of subconjunctival injection for the medical treatment of glaucoma. Journal of glaucoma 2013;22:190-194

39. Erdurmus M, Totan Y: Subconjunctival bevacizumab for corneal neovascularization. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2007;245:1577-1579

40. Dastjerdi MH, Sadrai Z, Saban DR, Zhang Q, Dana R: Corneal penetration of topical and subconjunctival bevacizumab. Investigative ophthalmology & visual science 2011;52:8718-8723

41. Rundhaug JE, Park J, Fischer SM: Uncoordinated regulation of mRNA expression of the three isoforms of transforming growth factor-beta in the mouse skin carcinogenesis model. Molecular carcinogenesis 1997;18:115-126

42. Liu G, Ding W, Neiman J, Mulder KM: Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. The Journal of biological chemistry 2006;281:29479-29490

43. Samarakoon R, Overstreet JM, Higgins SP, Higgins PJ: TGF-beta1 --> SMAD/p53/USF2 --> PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell and tissue research 2012;347:117-128

44. Samarakoon R, Higgins PJ: Integration of non-SMAD and SMAD signaling in TGF-beta1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells. Thrombosis and haemostasis 2008;100:976-983

45. Henderson J, Ferguson MW, Terenghi G: The reinnervation pattern of wounds and scars after treatment with transforming growth factor beta isoforms. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2012;65:e80-86

46. Han A, Bandyopadhyay B, Jayaprakash P, Lua I, Sahu D, Chen M, Woodley DT, Li W: The anti-motility signaling mechanism of TGFbeta3 that controls cell traffic during skin wound healing. Biol Open 2012;1:1169-1177

of 148 Diabetes

24

47. Laverty HG, Occleston NL, Johnson M, Little J, Jones R, Fairlamb D, Ferguson MW, O'Kane S: Effects of avotermin (transforming growth factor beta3) in a clinically relevant pig model of long, full-thickness incisional wounds. Journal of cutaneous medicine and surgery 2010;14:223-232

48. Bush J, So K, Mason T, Occleston NL, O'Kane S, Ferguson MW: Therapies with emerging evidence of efficacy: avotermin for the improvement of scarring. Dermatol Res Pract 2010;2010

49. Costa PZ, Soares R: Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox. Life sciences 2013;

50. Saghizadeh M, Kramerov AA, Tajbakhsh J, Aoki AM, Wang C, Chai NN, Ljubimova JY, Sasaki T, Sosne G, Carlson MR, Nelson SF, Ljubimov AV: Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Invest Ophthalmol Vis Sci 2005;46:3604-3615

of 148Diabetes

25

FIGURE LEGENDS

Figure 1: Expression profiling of genes differentially expressed in epithelial cells in

response to wounding in STZ diabetic and control, non-diabetic rat corneas. (A) To create

an epithelial debridement wound, epithelium were marked by 5 mm trephine and epithelial cells

within the mark were removed and collected as homeostatic CECs. The wounds were allowed

to healing for 42 h and the epithelial cells migrated into the original wound bed were scrapped

and referred as healing CECs. The samples were used for RNA preparation and subjected to

Affymetrix GeneChip Rat Genome 230 2.0 Array analysis. Binary comparisons were made as

indicated, creating differential expression profiles and significance measures corresponding to

the indicated effects, each based on the mean and variance of three independent

experiments. (B) Venn diagrams indicating overlap of genes induced due to wounding in NL

and DM rats. The cut off values are 2-fold difference for healing versus homeostatic and 1.5 for

DM versus NL. Each circle represents the pairwise comparison indicated.

Figure 2. Realtime-PCR verification of the expression patterns of 6 selected genes in

healing versus homeostatic CECs in NL rat corneas. The RNA samples obtained as

described in Figure 1. The scraped CECs from non-diabetic (NL) and STZ diabetic (DM) rat

corneas for creating a wound were marked as 0h and from the wound bed 42 hpw were

subjected to real-time PCR with primers specific for S100A9 (A), CXCL14 (B), Wnt2 (C), Ephx2

(D), Vim (E), and MMP12 (F). The data were presented as fold changes over non-diabetic,

homeostatic CECs (1). Each condition had 3 samples collected from 3 rats, two independent

experiments were performed; *p < 0.05; ** p < 0.01.

Figure 3. mRNA Expression of TGFβ isoforms detected by RT-PCR and verification of

TGFβ3 expression by realtime-PCR. The RNA samples obtained as described in Figure 1.

The scraped CECs from non-diabetic (NL) and STZ diabetic (DM) rat and mouse corneas for

of 148 Diabetes

26

creating a wound were marked as UW and from the wound bed 42 hpw (rats) or 24 hpw (mice)

were subjected to RT-PCR with GAPDH as the internal control and IL-1β as a positive control.

The data were presented as fold changes over non-diabetic, homeostatic CECs (1). Each

condition had 3 samples collected from 3 rats/mice, four independent experiments were

performed, 2 with SD and STZ-SD, 1 with Wistar and GK rats, and 1 with B6 and STZ B6

mouse; *p < 0.05; ** p < 0.01.

Figure 4. Immunohistochemistry of TGFβ3 distribution in healing and unwounded

corneas. The corneas of SD and STZ SD were wounded and OCT snap frozen at 42hpw

followed by sectioning and immunostaining with antibodies against TGFβ3; DAPI was used to

stain nuclei. The low magnification (5x) images entire cornea were taken and image stitched to

present the whole from limbus to wound center. Inserts are high magnification (20X) image of

the leading edge. The figure is representatives of 3 corneas per condition from 2 independent

experiments.

Figure 5. Effects of siRNA knockdown of TGFβ3 on corneal epithelial wound healing in

Wistar rats. (A) TGFβ3 specific and control, nonspecific siRNA were injected into

subconjunctival space at two sites (10 µl of 10 µM each site) of NL SD rats 6 hours prior to

wounding. A 5-mm wound was made in the central cornea and allowed to healing for 42 h,

fluorescence stained, and photographed. (B). Changes in the mean of the remaining wound

areas in pixels were calculated by Adobe Photoshop software, **P< 0.01, n=5. (C). CECs

collected during wounding (first 2 lanes) and 42 hpw were extracted and subjected to Western

blotting with list antibodies, two samples out of 5 from each condition were shown with actin as

the internal control. These figures are representatives of 5 corneas per condition from 2

independent experiments; ** p < 0.01.

of 148Diabetes

27

Figure 6. Effects of TGFβ3 on epithelial wound closure in GK rat corneas. (A) A total of

40 ng recombinant TGFβ3, with PBS as the control, was injected into subconjunctival space at

two sites (10 µl each) of GK rats 4 hours prior to wounding. Corneal epithelial wound of 5-mm

diameter was made and allowed to heal for 42 h and then fluorescence stained, and

photographed. (B) Changes in the mean of the remaining wound areas in pixels were calculated

by Adobe Photoshop software with p value listed, n=5. (C). CECs collected during wounding

(Con) and 42 hpw in PBS and TGFβ3 treated corneas were extracted and subjected to Western

blotting with list antibodies; two samples out of 5 from post wounding corneas were shown with

actin as the internal control. The anti-TGFβ1-3 antibodies recognize both latent (44, 25, 47 kDa,

respectively) and active (15, 12, 15 kDa, respectively) forms, giving two bands in Western

blotting. These figures are representatives of 5 corneas per condition from 2 independent

experiments; ** p < 0.01.

Figure 7. Effects of TGFβ3 on epithelial wound closure in B6 and STZ B6 mouse

corneas. (A) A total of 14 ng recombinant TGFβ3, with PBS as the control, was injected into

subconjunctival space at inferior side of B6 and STZ B6 mice 4 hours prior to wounding. A 2 mm

epithelial wound was made and allowed to heal for 16 h in B6 mice and 24 h in STZ B6 mice,

and then fluorescence stained, and photographed. 1) NL cornea injected with PBS, 2) NL

corneal injected with TGFβ3, 3) DM (STZ) cornea injected with PBS, 4) DM corneal injected

with TGFβ3. (B) Changes in the mean of the remaining wound areas in pixels were calculated

by Adobe Photoshop software with p value listed, n=5. (C). CECs collected during wounding

(first 2 lanes) and 16 hpw (1, 2) or 24 hpw (3, 4) in PBS (1, 3) and TGFβ3 (2, 4) treated corneas

were extracted and subjected to realtime-PCR analysis for Serpine1 expression, N=3, **p

<0.01.

of 148 Diabetes

28

Figure 8. Expression and distribution of TGFβ3 in cultured human NL and DM corneas

with or without wounding. Human diabetic corneas (B and D) and age matched controls (A

and C) were either directly processed for (A and B) or wounded (6 mm) prior to organ culture as

described by Saghizadeh et al (50). Ten days post-wounding, corneas were frozen in OCT.

The cryostat sections were stained with rabbit anti-human TGFβ3 antibody with nonspecific

rabbit IgG as negative control (Insert c’ in NL healed cornea, C). Photos show merged images

of confocal microscopy and are the representative of two subjects in each group.

of 148Diabetes

101x139mm (300 x 300 DPI)

of 148 Diabetes

226x346mm (300 x 300 DPI)

of 148Diabetes

203x203mm (300 x 300 DPI)

of 148 Diabetes

181x101mm (300 x 300 DPI)

of 148Diabetes

138x152mm (300 x 300 DPI)

of 148 Diabetes

201x203mm (300 x 300 DPI)

of 148Diabetes

193x152mm (300 x 300 DPI)

of 148 Diabetes

635x381mm (72 x 72 DPI)

of 148Diabetes

Supplemental Material 1: Defferentially Expressed genes in rat corneaal epithelia detected by Genome-wide cDNA array

NL42 vs NL0 DM42 vs DM0 DM0 vs NL0 (DM42 vs NL42

Gene SymbolGene Title p-value Fold-Change p-value Fold-Change p-value Fold-Change p-value Fold-Change

RT1-EC2 RT1 class Ib, locus EC2 0.843977 -1.24066 0.500781 2.11252 0.182875 4.6966 0.045484 12.3094

Ephx2 epoxide hydrolase 2, cytoplasmic0.0596885 1.34846 0.575894 1.08276 4.45E-08 14.8351 8.65E-08 11.9119

LOC100364500 /// RT1-A3 /// RT1-CE10 /// RT1-CE2 /// RT1-EC2RT1 class I, locus CE11-like /// RT1 class I, locus A3 /// RT1 class I, locus CE10 /// 0.894602 -1.12441 0.311257 2.52632 0.379933 2.21839 0.064084 6.3016

LOC690700 /// LOC691600similar to similar to RIKEN cDNA 1700001E04 /// similar to Discs large homolog 5 (Place0.986099 -1.00622 0.112701 1.84974 0.01631 2.84654 0.001306 5.29813

LOC100911353uncharacterized LOC1009113530.643924 1.22713 0.021928 3.34998 0.311375 1.58495 0.008864 4.32683

LOC689329 Hypothetical protein LOC6893290.883004 1.0564 0.180134 1.69946 0.046528 2.33814 0.006321 3.76146

LOC679551 Similar to MIC2 like 1 0.686628 -1.11702 0.22118 1.42036 0.015246 2.25485 0.001322 3.57749

Nqo2 NAD(P)H dehydrogenase, quinone 20.807201 1.43613 0.327002 4.47267 0.949035 1.09925 0.416015 3.42349

LOC100360398hypothetical protein LOC1003603980.729935 1.12661 0.092178 1.89209 0.10526 1.83839 0.009626 3.08748

Arid2 AT rich interactive domain 2 (Arid-rfx like)0.65606 -1.15662 0.370181 1.34812 0.066696 1.94909 0.007696 3.03913

Gp2 glycoprotein 2 (zymogen granule membrane)0.832137 1.19458 0.34443 2.26087 0.626855 1.5074 0.232678 2.8529

Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like0.270521 -1.49291 0.191764 -1.62043 0.013859 2.89265 0.020035 2.66501

Gsta4 glutathione S-transferase alpha 40.0376208 -1.86749 0.177402 -1.44954 0.02499 1.99517 0.005536 2.57045

Hpgds hematopoietic prostaglandin D synthase0.215532 1.87831 0.033887 3.31263 0.459412 1.43946 0.082066 2.53867

Phgdh phosphoglycerate dehydrogenase1.54E-05 -3.50594 0.081093 -1.31171 0.644033 -1.06746 0.000145 2.50389

Ahdc1 AT hook, DNA binding motif, containing 1 [0.983365 1.00461 0.039453 1.69121 0.112251 1.46434 0.002914 2.46515

LOC363306 hypothetical protein LOC3633060.0483122 -2.24502 0.182064 -1.66137 0.134807 1.78218 0.035252 2.40827

Phb2 Prohibitin 2 0.983391 1.00617 0.96317 -1.01375 0.014843 2.42591 0.016485 2.37832

LOC301682 hypothetical gene supported by 0.961286 -1.01674 0.577448 1.21228 0.093148 1.88095 0.034904 2.31843

Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like0.226128 -1.20532 0.893382 1.0199 0.00265 1.84225 0.000434 2.26468

LOC680643 similar to MIC2 like 1 0.508527 -1.15135 0.923965 1.02026 0.012323 1.92493 0.003917 2.26117

Auts2l autism susceptibility candidate 2-like0.0001602 -4.57997 0.000732 -3.35719 0.060775 1.64673 0.007632 2.24651

RT1-Ba RT1 class II, locus Ba 0.466539 1.13898 0.004637 1.93763 0.223331 1.25196 0.002164 2.12984

Smarcad1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a,0.791764 -1.07133 0.042781 1.8353 0.778922 1.07603 0.017891 2.11571

RGD1310352similar to HTGN29 protein; keratinocytes associated transmembrane protein 20.865548 1.06245 0.835257 1.07729 0.067958 2.07678 0.063853 2.10577

Zfp212 Zinc finger protein 212 0.227265 -1.44708 0.772005 -1.08839 0.146752 1.57468 0.030894 2.09363

Angptl4 angiopoietin-like 4 0.002238 -2.4023 0.791317 1.0558 0.333922 -1.22637 0.006387 2.06817

RGD1560691similar to calcium/calmodulin-dependent protein kinase 1D0.0002781 -2.33018 4.36E-05 -3.01299 0.000102 2.66033 0.000789 2.05744

Cdca7 cell division cycle associated 70.034444 1.62688 0.00032 3.15578 0.861502 1.03505 0.006541 2.00777

Man2a2 mannosidase 2, alpha 20.0023149 -1.94186 0.203497 -1.23283 0.154901 1.26794 0.00181 1.99718

Ly6g6e lymphocyte antigen 6 complex, locus G6E0.0801306 -2.13942 0.468417 -1.33507 0.610052 1.22322 0.114225 1.96018

Rarb Retinoic acid receptor, beta0.0111808 2.15698 0.000238 4.35726 0.868194 -1.04097 0.022177 1.94056

of 148 Diabetes

Pdyn prodynorphin 0.0310565 -2.72204 0.006422 -4.06565 0.024604 2.88355 0.124579 1.9306

Aqp4 aquaporin 4 2.90E-05 19.8151 6.74E-06 38.0072 0.993011 1.00319 0.100606 1.92422

Acsbg1 acyl-CoA synthetase bubblegum family member 10.0003452 -4.71648 0.003054 -2.98266 0.486371 1.20985 0.037809 1.91314

Krt4 keratin 4 0.0480542 1.42568 0.006664 1.73761 0.01824 1.56792 0.002771 1.91097

Ankrd34b ankyrin repeat domain 34B0.342621 1.1907 0.021025 1.64136 0.099072 1.38098 0.005865 1.90366

LOC100909409 /// LOC501467 /// LOC683878 /// LOC685183 /// LOC686886 /// LOC688649 /// LOC689453 /// LOC689635disks large homolog 5-like /// similar to spermatogenesis associated glutamate (0.680038 -1.08186 0.955314 1.01069 0.01676 1.74009 0.008106 1.90267

Gpr123 G protein-coupled receptor 1230.778767 -1.05719 0.630521 1.10044 0.036232 1.61753 0.01081 1.8818

Phyhip phytanoyl-CoA 2-hydroxylase interacting protein2.57E-08 -9.18243 5.45E-08 -7.50359 0.003442 1.53515 0.000313 1.87862

Fus fused in sarcoma 0.62965 -1.07898 0.311753 1.17788 0.033341 1.4756 0.003223 1.87534

Cdc20 cell division cycle 20 homolog (S. cerevisiae)9.56E-05 2.0614 5.68E-07 4.22226 0.3445 -1.10674 0.00029 1.8507

Sbk1 SH3-binding domain kinase 11.42E-05 -3.04604 0.001019 -1.82244 0.429784 1.10439 0.000892 1.84588

Padi4 peptidyl arginine deiminase, type IV4.23E-05 -2.08817 0.153917 -1.15522 0.8543 1.01753 0.000161 1.83928

Fcrla Fc receptor-like A 0.683408 -1.27366 0.527742 -1.45853 0.229797 2.10295 0.318823 1.83639

Cdh10 cadherin 10 0.175249 -1.15852 0.597724 1.05586 0.003422 1.50074 0.000277 1.83576

S100g S100 calcium binding protein G9.89E-05 12.5272 4.08E-05 17.5155 0.469723 1.30867 0.126724 1.82977

Mt2A metallothionein 2A 5.63E-07 5.96815 1.69E-07 8.05191 0.041934 1.35323 0.001333 1.82571

RT1-Ba RT1 class II, locus Ba 0.552341 1.11998 0.011236 1.81968 0.556627 1.11858 0.011351 1.81741

Cdc20 Cell division cycle 20 homolog (S. cerevisiae)0.0003634 1.86051 2.21E-06 3.51974 0.673589 -1.0471 0.0005 1.80672

GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A3.33E-05 -2.95707 0.029699 -1.41145 0.279745 -1.16337 0.001984 1.80086

Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide2.80E-06 -15.5608 1.80E-05 -8.50938 0.942785 -1.0177 0.038502 1.79685

Elovl4 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 40.0947929 2.30208 0.572899 1.29526 0.030089 3.18504 0.221653 1.79207

Ikbkb Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.0492979 -2.13529 0.143379 -1.7017 0.31331 1.42273 0.11492 1.78525

Pofut1 protein O-fucosyltransferase 10.609677 -1.10101 0.417713 1.16739 0.11844 1.3727 0.01392 1.76435

Pofut1 protein O-fucosyltransferase 10.609677 -1.10101 0.417713 1.16739 0.11844 1.3727 0.01392 1.76435

SLC16A12 solute carrier family 16, member 12 (monocarboxylic acid transporter 12)1.74E-06 -25.079 5.16E-06 -16.3199 0.612581 1.14758 0.061696 1.76351

Efcab6 EF-hand calcium binding domain 60.1272 1.64328 0.004324 3.15362 0.777344 -1.08912 0.088212 1.76207

Mki67 antigen identified by monoclonal antibody Ki-674.79E-05 2.35844 1.48E-06 3.92964 0.621266 1.0574 0.000809 1.76185

Bnc2 basonuclin 2 0.0287457 1.68499 0.00119 2.61479 0.544747 1.13201 0.020708 1.75666

Cdc20 cell division cycle 20 homolog (S. cerevisiae)0.0003052 2.15749 1.66E-06 4.83732 0.088894 -1.27887 0.00223 1.75319

Plk1 polo-like kinase 1 (Drosophila)6.55E-06 3.04517 1.63E-07 6.06613 0.257771 -1.14002 0.000833 1.74738

LOC685157 /// LOC686862similar to paired immunoglobin-like type 2 receptor beta /// similar to paired immunogl0.689483 -1.05216 0.025886 1.39775 0.197833 1.18806 0.00188 1.74722

Gsr glutathione reductase 0.660716 -1.13219 0.353029 1.30816 0.561547 1.17939 0.074822 1.74679

Cenpe centromere protein E 9.66E-06 3.15498 2.64E-07 6.30577 0.261082 -1.15185 0.001513 1.73519

Vom2r40 vomeronasal 2 receptor, 400.993321 1.00154 0.174655 1.30503 0.147731 1.33161 0.015039 1.73511

Mfhas1 malignant fibrous histiocytoma amplified sequence 10.0005027 2.07993 0.000625 2.03038 0.00228 1.77604 0.002926 1.73373

of 148Diabetes

LOC688832 Hypothetical protein LOC6888320.178691 1.28089 0.172273 1.28625 0.011693 1.72612 0.011267 1.73334

Cdt1 chromatin licensing and DNA replication factor 10.788791 -1.03941 0.009152 1.61051 0.81562 1.0342 0.004337 1.73123

Mx2 myxovirus (influenza virus) resistance 20.505174 1.5301 0.116391 2.92483 0.874325 -1.10469 0.394718 1.73037

RGD1305807hypothetical LOC2980770.679341 -1.02971 0.038325 1.18422 0.000942 1.4155 4.39E-05 1.72607

Cdc20 Cell division cycle 20 homolog (S. cerevisiae)0.0102872 2.01079 0.000654 3.09064 0.595928 1.12255 0.031362 1.7254

Kif1b kinesin family member 1B0.32265 1.10991 0.001055 1.63973 0.160499 1.16536 0.00058 1.72165

Fam149b1 Fam149b1 family with sequence similarity 149, member B10.367258 -1.10937 0.366338 1.10961 0.015049 1.39776 0.001058 1.72059

Fam149b1 Fam149b1 family with sequence similarity 149, member B10.367258 -1.10937 0.366338 1.10961 0.015049 1.39776 0.001058 1.72059

Gprc5b G protein-coupled receptor, family C, group 5, member B0.0076199 2.18024 0.001011 3.02842 0.360444 1.2381 0.039166 1.71977

Camta1 similar to KIAA0833 protein0.812875 -1.04917 0.272416 1.26013 0.220205 1.2981 0.024935 1.71622

Meis2 Meis homeobox 2 0.179414 -1.23548 0.894302 -1.01991 0.042649 1.41349 0.005689 1.71226

Kif20a kinesin family member 20A1.41E-05 2.38266 1.86E-07 4.62656 0.20909 -1.13544 0.000419 1.71014

Zfp346 zinc finger protein 346 0.394258 -1.14887 0.588651 1.09072 0.079655 1.36258 0.008436 1.70744

Ccdc74a coiled-coil domain containing 74A0.0146629 -1.25196 0.049732 1.18223 0.084878 1.15315 7.80E-05 1.70678

Ate1 arginyltransferase 1 0.879074 -1.03234 0.747833 1.06975 0.064406 1.54389 0.030011 1.70498

Ate1 arginyltransferase 1 0.879074 -1.03234 0.747833 1.06975 0.064406 1.54389 0.030011 1.70498

RT1-CE5 RT1 class I, locus CE5 0.0109471 13.7939 0.009058 15.2704 0.605652 1.5342 0.524746 1.69843

RGD1564046similar to RIKEN cDNA 4933417K05 gene0.907745 -1.01611 0.030844 1.41844 0.254251 1.17837 0.004155 1.69837

Gpha2 glycoprotein hormone alpha 28.82E-05 -4.71189 0.000957 -2.96192 0.769948 1.06685 0.038515 1.69716

Hmgxb4 HMG box domain containing 40.270975 1.18135 0.016646 1.52985 0.091631 1.31009 0.005621 1.69657

Hmgxb4 HMG box domain containing 40.270975 1.18135 0.016646 1.52985 0.091631 1.31009 0.005621 1.69657

Bst1 bone marrow stromal cell antigen 12.36E-09 -12.5559 3.85E-09 -10.7954 0.002762 1.4562 0.000334 1.69368

Akr1b8 aldo-keto reductase family 1, member B80.0030202 7.26319 0.025375 3.65546 0.033642 3.35444 0.300161 1.68824

Psat1 phosphoserine aminotransferase 12.95E-06 2.38137 2.50E-06 2.42809 0.000155 1.6557 0.000119 1.68819

Ggta1 Glycoprotein, alpha-galactosyltransferase 10.0133628 2.6233 0.005319 3.17666 0.308454 1.39343 0.124683 1.68736

Eif3k Eukaryotic translation initiation factor 3, subunit K0.89436 -1.03046 0.067615 1.58801 0.893616 1.03068 0.044023 1.68659

Slc22a4 solute carrier family 22 (organic cation transporter), member 43.39E-05 -7.03289 0.001079 -3.22947 0.301519 -1.2969 0.058826 1.67918

Dscr6 Down syndrome critical region homolog 6 (human)1.04E-06 -3.60101 8.24E-06 -2.6512 0.066472 1.229 0.000749 1.66929

Wdr34 WD repeat domain 34 0.0877181 -1.79537 0.122476 -1.68146 0.176236 1.56274 0.1273 1.66861

Fam64a family with sequence similarity 64, member A0.0016168 2.26839 1.91E-05 4.82689 0.199935 -1.27811 0.019827 1.66487

Dullard Dullard homolog (Xenopus laevis)0.609311 1.07713 0.4451 1.11875 0.009862 1.60018 0.006627 1.662

LOC688280 similar to transmembrane channel-like protein 6 isoform 10.0157 -1.23416 0.01058 -1.25666 6.09E-05 1.69201 7.81E-05 1.66171

Heph hephaestin 1.55E-06 -10.3181 4.83E-06 -7.45698 0.360341 1.19819 0.026542 1.65792

Mybl2 myeloblastosis oncogene-like 25.57E-06 4.12557 8.07E-07 6.21237 0.495354 1.10043 0.00547 1.65705

Ccnb1 cyclin B1 1.49E-05 2.60399 3.11E-07 4.91453 0.237492 -1.14092 0.001233 1.6542

of 148 Diabetes

Pik3c2b phosphoinositide-3-kinase, class 2, beta polypeptide0.0127131 -2.08062 0.017495 -1.98245 0.083943 1.57224 0.0605 1.6501

LOC691918 similar to Centrosomal protein of 27 kDa (Cep27 protein)0.0250153 -1.37026 0.946677 -1.00793 0.130915 1.21249 0.002397 1.64835

RGD1311723similar to KIAA1731 protein0.70404 1.11502 0.368179 1.3017 0.248475 1.41076 0.10879 1.64696

Prkag2 Protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.754441 -1.0464 0.095606 1.30293 0.216742 1.20668 0.007471 1.64517

Asb13 ankyrin repeat and SOCS box-containing 130.0226977 -1.5537 0.384271 -1.15502 0.235379 1.22251 0.01306 1.64449

Nrf1 nuclear respiratory factor 10.224424 1.11585 0.004777 1.37955 0.009099 1.32931 0.000335 1.64345

Tecpr2 tectonin beta-propeller repeat containing 20.704345 -1.06558 0.099069 1.35161 0.437704 1.141 0.015215 1.64333

MBNL2 muscleblind-like 2 (Drosophila)0.89628 -1.01915 0.54313 1.09366 0.025122 1.47324 0.007869 1.64207

Eri2 exoribonuclease 2 0.0001518 -3.13261 0.003545 -2.00245 0.783911 1.04948 0.019539 1.6418

Aldh1l2 aldehyde dehydrogenase 1 family, member L20.0061466 1.21455 1.37E-06 1.95494 0.728181 1.01915 1.35E-05 1.64042

Aspm asp (abnormal spindle) homolog, microcephaly associated (Drosophila)0.0005439 1.71047 2.52E-06 3.1173 0.308147 -1.11109 0.000916 1.64026

Adrb1 Adrenergic, beta-1-, receptor4.58E-05 -6.58162 0.000366 -4.04245 0.976677 1.00718 0.070485 1.63981

Dsel dermatan sulfate epimerase-like0.0001271 7.835 3.28E-05 12.062 0.842166 1.06348 0.138041 1.63724

RGD1564677Similar to transcription factor ONECUT20.211836 -1.16172 0.864918 1.0196 0.019032 1.38201 0.002107 1.63696

LOC302495 hypothetical LOC3024950.0897501 -1.46516 0.213831 -1.30643 0.092483 1.45954 0.037541 1.63688

Rtn4ip1 reticulon 4 interacting protein 10.464122 -1.08671 0.148343 1.1889 0.060189 1.2669 0.001861 1.63682

Rtn4ip1 reticulon 4 interacting protein 10.464122 -1.08671 0.148343 1.1889 0.060189 1.2669 0.001861 1.63682

Pcdh20 protocadherin 20 0.787515 -1.02722 0.006794 1.41712 0.259389 1.12406 0.000917 1.63627

Siglec5 sialic acid binding Ig-like lectin 50.0529713 1.75476 0.005945 2.50869 0.607515 1.14164 0.083465 1.63215

Igfbp2 insulin-like growth factor binding protein 21.48E-07 -3.09651 3.42E-05 -1.73546 0.215449 -1.09375 8.02E-05 1.63133

Cenpf centromere protein F 0.0074297 1.45924 1.20E-05 2.757 0.201196 -1.15946 0.001764 1.6295

Tecpr2 tectonin beta-propeller repeat containing 20.622233 -1.04332 0.086361 1.17563 0.009019 1.3278 0.000365 1.62864

Khdrbs1 KH domain containing, RNA binding, signal transduction associated 10.912059 1.01406 0.169301 1.20332 0.032422 1.37238 0.004058 1.62851

Mcm5 minichromosome maintenance complex component 50.0213857 1.60907 0.000877 2.35914 0.547139 1.1105 0.019187 1.62815

Ptprh protein tyrosine phosphatase, receptor type, H0.787473 1.12999 0.521326 -1.34176 0.073421 2.46641 0.299242 1.62673

Rbms3 RNA binding motif, single stranded interacting protein 30.970469 1.00542 0.023958 1.48159 0.508406 1.10287 0.008914 1.6252

Racgap1 Rac GTPase-activating protein 10.0134284 1.53883 3.79E-05 3.04439 0.181893 -1.22081 0.007648 1.62055

Caprin1 cell cycle associated protein 10.622308 1.07972 0.068571 1.37018 0.141219 1.27689 0.012172 1.62039

Stard5 StAR-related lipid transfer (START) domain containing 50.593696 1.03634 0.001269 1.36572 0.012625 1.22818 6.96E-05 1.61854

Dna2 DNA replication helicase 2 homolog (yeast)0.686204 1.0484 0.028805 1.3499 0.07781 1.25618 0.00275 1.61743

Mt1a metallothionein 1a 5.26E-07 6.8284 1.26E-07 10.0664 0.509318 1.09644 0.006962 1.61637

Rab14 RAB14, member RAS oncogene family0.973787 -1.00641 0.851618 -1.03707 0.027136 1.6627 0.034752 1.61354

ZMYND8 zinc finger, MYND-type containing 80.986104 -1.00268 0.142115 1.27494 0.158942 1.26077 0.01262 1.61172

Fas Fas (TNF receptor superfamily, member 6)3.37E-06 -3.41285 1.85E-05 -2.65773 0.070619 1.25395 0.002324 1.61022


of 148Diabetes

LOC100909941uncharacterized LOC1009099410.210551 -1.55875 0.050621 -2.11574 0.043582 2.18297 0.183188 1.60828

Rfc5 Replication factor C (activator 1) 50.298678 -1.10718 0.043304 1.2457 0.132451 1.16586 0.000838 1.60796

Klrg1 killer cell lectin-like receptor subfamily G, member 10.720002 1.04608 0.042878 1.33865 0.098981 1.25404 0.004549 1.60477

Lmnb2 Lamin B2 0.296764 1.09875 0.000504 1.60535 0.311709 1.09539 0.000526 1.60043

Fam120a family with sequence similarity 120A0.841087 1.02053 0.129001 1.18062 0.010965 1.38139 0.001393 1.59808

Cyp2c6 cytochrome P450, family 2, subfamily c, polypeptide 6 /// cytochrome P450-like0.738847 -1.04216 0.036894 1.34871 0.317835 1.13591 0.004473 1.5966

Dpyd dihydropyrimidine dehydrogenase0.0909986 1.21211 0.000401 1.78912 0.462827 1.08028 0.001626 1.59453

Ube3c Ubiquitin protein ligase E3C0.914632 -1.02201 0.687169 1.08567 0.102715 1.43693 0.045218 1.59437

Kif20b kinesin family member 20B0.0029617 1.66742 1.75E-05 3.00891 0.336635 -1.13221 0.004969 1.59382

Atp6v1g3 ATPase, H+ transporting, lysosomal V1 subunit G30.287931 1.13268 0.008573 1.4603 0.089037 1.23587 0.002776 1.59334

Il27ra interleukin 27 receptor, alpha0.632704 -1.03677 0.003828 1.33957 0.096255 1.14678 0.000208 1.59267

Rbms3 RNA binding motif, single stranded interacting protein 30.0265702 -1.26459 0.179471 1.13579 0.272173 1.10746 0.000676 1.59066

Kif22 kinesin family member 220.0001606 1.95561 2.17E-06 3.34702 0.485421 -1.07654 0.001761 1.58981

Tmem176b transmembrane protein 176B0.0590108 -1.36396 0.051998 -1.37965 0.009931 1.60657 0.011205 1.58829

Mical3 microtubule associated monoxygenase, calponin and LIM domain containing 3 [0.28374 1.17131 0.018611 1.49939 0.159358 1.23803 0.01014 1.5848

Mical3 microtubule associated monoxygenase, calponin and LIM domain containing 3 [0.28374 1.17131 0.018611 1.49939 0.159358 1.23803 0.01014 1.5848

zinc finger and SCAN domain containing 10Zscan10 0.435052 -1.08922 0.045414 -1.27922 0.000334 1.8611 0.002208 1.58467

Hoxc9 Homeobox C9 0.713229 1.05025 0.101833 1.26851 0.06839 1.31124 0.007273 1.58374

Krt15 keratin 15 8.37E-07 19.0848 3.98E-07 25.7012 0.479086 1.17512 0.067693 1.58252

Kif13a Kinesin family member 13A0.828254 -1.02513 0.070637 1.25958 0.104341 1.22485 0.003252 1.58156

Spr sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)0.0135443 1.52046 0.000134 2.4773 0.820607 -1.03164 0.008843 1.57934

Tkt transketolase 5.68E-05 -4.65672 0.000747 -2.86613 0.888466 -1.0293 0.051393 1.57849

H1f0 H1 histone family, member 00.16582 -1.11897 0.010284 1.27885 0.221495 1.10268 0.000263 1.57792

LOC690769 similar to zinc ring finger protein 10.0877685 1.3466 0.03087 1.49229 0.051265 1.41978 0.018114 1.57338

Mpped1 metallophosphoesterase domain containing 10.0063528 -1.84577 0.141796 -1.31328 0.519316 1.1193 0.02668 1.57314

Kprp keratinocyte proline-rich protein0.868275 1.05677 0.609328 1.18703 0.327624 1.39953 0.198189 1.57204

Espl1 extra spindle pole bodies homolog 1 (S. cerevisiae)0.0001721 2.4793 5.05E-06 4.38276 0.413149 -1.1264 0.011381 1.56938

Onecut1 one cut homeobox 1 0.775033 -1.03009 0.026579 1.31249 0.175651 1.16065 0.00202 1.56918

Agr2 anterior gradient homolog 2 (Xenopus laevis)0.602632 1.22293 0.119421 1.91063 0.992762 1.00348 0.260505 1.56778

LOC100360211hypothetical LOC1003602110.564105 -1.07784 0.464756 1.10037 0.055752 1.32133 0.006927 1.56712

Wwp2 WW domain containing E3 ubiquitin protein ligase 20.90977 1.02084 0.06787 1.45083 0.597975 1.10167 0.034598 1.5657

Rcc1 regulator of chromosome condensation 10.0035056 1.51438 0.000116 2.02914 0.167742 1.16659 0.002294 1.56312

Rfc5 replication factor C (activator 1) 50.0795686 -1.19755 0.046607 1.23504 0.556259 1.05668 0.001089 1.56286


Unc79 unc-79 homolog (C. elegans)0.743094 -1.04152 0.072613 1.28111 0.227007 1.16984 0.005918 1.56092

of 148 Diabetes

Hells helicase, lymphoid specific0.012104 1.86642 0.000302 3.22867 0.608518 -1.10855 0.050357 1.56047

Top2a topoisomerase (DNA) II alpha0.0006769 1.56239 4.08E-06 2.50334 0.754711 -1.02728 0.000694 1.5597

Klra17 /// LOC100364751 /// LOC497796 /// LOC502907 /// Ly49i5 /// Ly49si1 /// Ly49si2 /// Ly49si3 /// RGD1561306killer cell lectin-like receptor, subfamily A, member 17 /// immunoreceptor Ly49si3-lik0.320629 1.20883 0.058223 1.48527 0.220084 1.26909 0.038112 1.55931

Nol4 nucleolar protein 4 0.198194 -1.17374 0.75379 -1.03776 0.023087 1.37719 0.004665 1.55765

Foxp1 forkhead box P1 0.787581 1.02106 0.004164 1.34494 0.055339 1.18248 0.000352 1.55756

Dut Deoxyuridine triphosphatase0.783568 1.05417 0.301743 1.22753 0.158003 1.33539 0.044745 1.555

Akr1c14 aldo-keto reductase family 1, member C140.0003323 -4.60251 0.000514 -4.17475 0.215496 1.41004 0.122464 1.55451

Il17b interleukin 17B 0.0268118 2.12727 0.002603 3.32128 0.984183 -1.00572 0.153491 1.55241

Nrf1 nuclear respiratory factor 10.6545 1.06158 0.064006 1.31808 0.121952 1.24909 0.009188 1.55089

Chaf1a chromatin assembly factor 1, subunit A (p150)0.0765074 1.28482 0.000925 1.87625 0.640757 1.0616 0.007439 1.55028

Usp33 Ubiquitin specific peptidase 330.759751 1.05372 0.401964 1.15758 0.071144 1.41039 0.029333 1.5494

Camk2g calcium/calmodulin-dependent protein kinase II gamma0.794415 1.04326 0.078162 1.37349 0.332692 1.17591 0.023897 1.54814

Pde3b phosphodiesterase 3B, cGMP-inhibited0.685644 1.05868 0.049643 1.36866 0.223754 1.19616 0.012434 1.54639

Ankrd17 Ankyrin repeat domain 170.263179 1.15543 0.086627 1.26416 0.02055 1.41281 0.006705 1.54576

Tcfap2b transcription factor AP-2 beta0.305458 1.16225 0.018539 1.49868 0.223773 1.19854 0.013197 1.54547

Gnrhr gonadotropin releasing hormone receptor0.984812 -1.00258 0.062375 1.32907 0.294942 1.15871 0.010785 1.54399

Exo1 exonuclease 1 0.002295 2.08708 4.86E-05 3.73957 0.399566 -1.16053 0.031825 1.54393

Mybl2 myeloblastosis oncogene-like 25.54E-05 2.27674 5.32E-06 3.10006 0.271762 1.13369 0.003514 1.54365

Ccnd1 cyclin D1 8.14E-07 -2.84403 2.16E-05 -1.96697 0.419389 1.06753 0.000479 1.54353

Ckap2 cytoskeleton associated protein 20.0132847 1.56996 8.84E-05 2.80786 0.32618 -1.16071 0.016205 1.54087

Akr1d1 aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.0695349 -1.23971 0.674066 1.04579 0.131749 1.18793 0.002958 1.54013

Ppp6r2 protein phosphatase 6, regulatory subunit 20.357105 -1.1656 0.891189 1.02239 0.141917 1.2911 0.025152 1.53861

Kif18b /// LOC100363850kinesin family member 18B /// kinesin-like protein KIF18B-like0.0073873 1.62731 9.36E-05 2.67184 0.638542 -1.06902 0.01384 1.53587

Wdhd1 WD repeat and HMG-box DNA binding protein 10.0708241 1.30704 0.001182 1.87948 0.622479 1.06804 0.010275 1.53581

Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 20.026959 1.25435 4.02E-05 1.97096 0.786693 -1.02374 0.000919 1.53486

Ppp1r18 protein phosphatase 1, regulatory subunit 187.07E-05 2.97214 1.42E-05 3.89035 0.306711 1.17235 0.018702 1.53454

Lect1 leukocyte cell derived chemotaxin 13.59E-05 -3.11494 2.50E-06 -5.08186 0.000163 2.50341 0.014708 1.53447

Ash1l Ash1 (absent, small, or homeotic)-like (Drosophila)0.695964 1.05953 0.19913 1.22111 0.079832 1.33135 0.017068 1.53439

Ppp2r2b protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform0.576919 1.19208 0.111331 1.71718 0.841782 1.06429 0.195027 1.5331

LOC301193 /// LOC363434 /// LOC501251 /// LOC690665 /// LOC691569similar to Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg0.638481 -1.06479 0.112479 1.25763 0.323812 1.14475 0.010503 1.53295

Adcy9 adenylate cyclase 9 0.610547 -1.04354 0.002876 1.40522 0.597845 1.04516 0.00072 1.53263

Matr3 Matrin 3 0.23187 -1.18818 0.737593 1.04732 0.158877 1.23006 0.012722 1.5307

Nr2c2 nuclear receptor subfamily 2, group C, member 20.168141 -1.20073 0.824297 1.02808 0.113388 1.23932 0.00782 1.52988

Slc16a1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)0.0018358 2.74054 6.61E-05 5.29615 0.320908 -1.26318 0.090326 1.52988

Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast)0.0002354 4.88348 7.72E-05 6.43929 0.571855 1.16023 0.130234 1.52986

of 148Diabetes

Ces3 Carboxylesterase 3 0.887623 1.01598 0.037595 1.31048 0.156836 1.185 0.004511 1.52849

Arhgap39 Rho GTPase activating protein 390.308694 1.16016 0.058149 1.35246 0.082794 1.3111 0.014572 1.52843

RT1-CE5 RT1 class I, locus CE5 0.0199427 6.52858 0.007244 10.1152 0.982312 -1.01492 0.531749 1.52661

Smc3 structural maintenance of chromosomes 30.141063 -1.18389 0.420927 -1.09164 0.010776 1.40722 0.003485 1.52614

Srgap2 SLIT-ROBO Rho GTPase activating protein 20.173322 -1.28073 0.074929 -1.40317 0.014587 1.67151 0.034068 1.52566

Troap trophinin associated protein0.0041487 1.5794 4.69E-05 2.49173 0.778212 -1.03415 0.006365 1.52555

Neurod6 neurogenic differentiation 60.54191 -1.07363 0.117689 1.21594 0.202818 1.16732 0.00541 1.52389

Pold2 polymerase (DNA directed), delta 2, regulatory subunit0.0880713 1.29831 0.002398 1.79808 0.501018 1.09936 0.014075 1.52255

Mme membrane metallo endopeptidase0.034145 -2.38639 0.339112 -1.41435 0.770692 -1.1083 0.252771 1.5224

Nol4 nucleolar protein 4 [Rattus norvegicus0.765245 -1.05101 0.468879 1.13024 0.162696 1.28095 0.03128 1.52163

Ncapd2 non-SMC condensin I complex, subunit D20.0088735 1.47677 4.98E-05 2.43818 0.488822 -1.0858 0.006097 1.52056

Cdca5 cell division cycle associated 50.0271652 1.32247 0.000399 1.82639 0.382567 1.10045 0.003736 1.51977

PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 21.00E-05 -4.52417 5.41E-05 -3.31606 0.504843 1.11382 0.026649 1.51961

NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 30.550569 -1.04397 0.022505 1.21499 0.031066 1.19763 0.000305 1.51909

Tff1 trefoil factor 1 0.071209 1.3248 0.009291 1.58505 0.115885 1.26936 0.014911 1.51873

Wdpcp WD repeat containing planar cell polarity effector0.0244717 -1.39819 0.438401 1.10389 0.897204 -1.0163 0.008727 1.5187

Zmym2 zinc finger, MYM-type 2 0.723042 -1.06834 0.756436 1.0595 0.141711 1.34116 0.049048 1.51807

Cdk1 cyclin-dependent kinase 17.28E-06 2.30853 2.53E-07 3.66176 0.604851 -1.04513 0.000942 1.51769

Gpr61 G protein-coupled receptor 610.688131 -1.0603 0.08041 1.32498 0.599531 1.07991 0.018041 1.51714

Neo1 Neogenin homolog 1 (chicken)0.149173 -1.12247 0.467928 1.05671 0.009428 1.27862 0.000427 1.51661

Usp49 ubiquitin specific peptidase 490.534995 1.07565 0.411214 1.10245 0.008311 1.47934 0.006048 1.51619

Nusap1 nucleolar and spindle associated protein 10.813452 -1.01706 0.000273 1.53258 0.692101 -1.0289 0.000328 1.51495


WIPF1 WAS/WASL interacting protein family, member 11.19E-05 -3.20962 7.32E-05 -2.47891 0.2341 1.16998 0.009295 1.51485

Traf4af1 TRAF4 associated factor 10.0007658 1.74435 1.39E-05 2.69183 0.855549 -1.02009 0.004466 1.51278

Ctsj cathepsin J 0.791841 -1.01759 0.107811 1.12266 0.002315 1.32393 0.000193 1.51248

Auts2l autism susceptibility candidate 2-like [6.20E-05 -1.60611 0.001743 -1.33171 0.006701 1.25318 0.000162 1.5114

Auts2l autism susceptibility candidate 2-like [6.20E-05 -1.60611 0.001743 -1.33171 0.006701 1.25318 0.000162 1.5114

Lipogenin Lipogenin 0.287561 1.16814 0.005192 1.68067 0.729514 1.05007 0.016437 1.5108

Gas5 growth arrest specific 5 0.003473 2.59337 0.000624 3.54014 0.67523 1.10653 0.114461 1.5105

Hmmr hyaluronan mediated motility receptor (RHAMM)0.0022924 1.89186 1.45E-05 3.85068 0.071469 -1.35128 0.022293 1.50626

Car3 carbonic anhydrase 3 0.782339 -1.03449 0.30917 1.13755 0.07143 1.27957 0.008711 1.50579

Zfp64 zinc finger protein 64 0.0184483 -1.23639 0.934711 1.0061 0.029292 1.20999 0.000463 1.50514

Dhx37 DEAH (Asp-Glu-Ala-His) box polypeptide 370.382311 1.19159 0.083248 1.45522 0.302527 1.23239 0.063182 1.50505

Otx2 orthodenticle homeobox 20.916634 -1.01283 0.051189 1.31035 0.318322 1.13377 0.008528 1.50469

of 148 Diabetes

Thoc4 THO complex 4 0.0004108 1.82604 3.69E-05 2.34436 0.165748 1.17194 0.004376 1.5046

Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.0011651 1.65682 2.58E-05 2.4184 0.775962 1.03068 0.004066 1.50444

Gtse1 G-2 and S-phase expressed 10.0271169 1.30798 5.04E-05 2.18177 0.32881 -1.10898 0.003421 1.50412


Prdm15 PR domain containing 150.0814295 1.31149 0.012702 1.54466 0.110893 1.27616 0.017212 1.50305

Actr2 ARP2 actin-related protein 2 homolog (yeast)0.0075765 1.684 0.019668 1.53351 0.009271 1.65031 0.024299 1.50283

Hjurp Holliday junction recognition protein0.0006665 1.7611 2.01E-05 2.55327 0.743146 1.03637 0.004767 1.50255


Tacc3 transforming, acidic coiled-coil containing protein 33.43E-06 2.49972 1.23E-07 4.0996 0.309483 -1.09213 0.001045 1.50167

Ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae)0.133508 1.27694 0.002058 1.92659 0.974518 -1.00484 0.024061 1.5015

Sv2b synaptic vesicle glycoprotein 2b0.0012152 -2.01798 0.000667 -2.16428 0.010713 1.60884 0.022423 1.50008

Kifc1 kinesin family member C11.22E-05 2.32107 5.76E-07 3.52375 0.894658 -1.01216 0.001793 1.49991

H2afx H2A histone family, member X0.0003749 1.53286 2.02E-06 2.41107 0.524654 -1.04961 0.000536 1.49858

LOC100362555androgen down regulated in mouse prostate0.0247339 -2.12796 0.014894 -2.33003 0.109103 1.63806 0.179413 1.496

Cldn10 claudin 10 0.0090867 2.14617 0.00105 3.05571 0.836428 1.04878 0.110287 1.49325

Depdc1 DEP domain containing 10.0035143 1.53732 1.15E-05 2.74894 0.122655 -1.19928 0.005285 1.49101

Tacr2 tachykinin receptor 2 4.29E-07 -42.0531 9.35E-07 -29.3664 0.879318 1.04041 0.1533 1.48988

Top2a topoisomerase (DNA) II alpha0.0024484 1.54619 1.95E-05 2.44873 0.55616 -1.06348 0.004095 1.48919

Gramd1b GRAM domain containing 1B6.93E-05 -2.62762 0.000828 -1.95264 0.457315 1.10583 0.014986 1.48809

Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E6.07E-05 1.5046 6.15E-07 2.1274 0.387995 1.05002 7.68E-05 1.48465

Dlgap5 discs, large (Drosophila) homolog-associated protein 50.0604578 1.256 0.000117 2.06764 0.351044 -1.10886 0.005338 1.48459

Asns asparagine synthetase 0.000119 3.10943 6.75E-05 3.41968 0.104443 1.34866 0.042279 1.48323

Cpt1a carnitine palmitoyltransferase 1a, liver0.0011697 -2.72786 0.012197 -1.93047 0.827014 1.04717 0.091171 1.47971

Yars tyrosyl-tRNA synthetase 4.01E-06 1.93082 4.04E-07 2.42967 0.026867 1.17479 0.000176 1.47831

Zfhx3 zinc finger homeobox 3 3.94E-05 -2.30328 3.99E-05 -2.29976 0.005338 1.47598 0.005225 1.47824

Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.0001039 1.99221 2.37E-06 3.16626 0.474284 -1.07581 0.003898 1.47732

Susd4 sushi domain containing 41.68E-06 -8.90178 3.45E-06 -7.31529 0.307259 1.21226 0.058769 1.47517

Foxe1 forkhead box E1 (thyroid transcription factor 2)0.0013313 -1.95408 6.57E-05 -2.86208 0.000551 2.15998 0.0235 1.47472

Ska1 spindle and kinetochore associated complex subunit 14.23E-05 2.37446 1.53E-06 3.85578 0.38935 -1.10291 0.00704 1.47233

Dlg1 discs, large homolog 1 (Drosophila)0.423678 -1.129 0.085686 -1.32584 0.005254 1.72728 0.027883 1.47084

Dlg1 discs, large homolog 1 (Drosophila)0.423678 -1.129 0.085686 -1.32584 0.005254 1.72728 0.027883 1.47084

LOC680211 hypothetical protein LOC6802110.002874 -2.87704 0.017594 -2.10525 0.779677 1.07495 0.162199 1.46903

Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.0028191 1.8176 3.25E-05 3.23224 0.208593 -1.2123 0.026176 1.46688

RGD1305464similar to human chromosome 15 open reading frame 390.0022096 1.78684 0.000146 2.42258 0.566806 1.08149 0.019346 1.46628

Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 60.0035017 -2.06252 0.001004 -2.44102 0.01442 1.73521 0.062784 1.46616

of 148Diabetes

Vwf von Willebrand factor 3.46E-06 -2.96332 5.00E-06 -2.8141 0.009001 1.39154 0.004163 1.46533

Kif15 kinesin family member 150.0065887 1.53188 0.000134 2.22601 0.946746 1.00811 0.011553 1.46491

Racgap1 Rac GTPase-activating protein 10.0009636 1.57068 4.17E-06 2.66119 0.140692 -1.1567 0.002662 1.46476

Prc1 protein regulator of cytokinesis 10.0004554 1.75193 5.82E-06 2.81473 0.356369 -1.1011 0.00495 1.45912

Fam83d family with sequence similarity 83, member D0.0002706 2.03488 3.59E-06 3.64236 0.113317 -1.22752 0.011332 1.4582

Eftud2 elongation factor Tu GTP binding domain containing 20.0033057 1.52294 9.70E-05 2.07213 0.518455 1.07124 0.006063 1.45755

Nop58 nucleolar protein NOP580.001028 1.54646 2.31E-05 2.13513 0.57787 1.05167 0.002639 1.452

Blm Bloom syndrome, RecQ helicase-like0.0021696 1.67929 3.44E-05 2.62582 0.543076 -1.07698 0.01274 1.45189

Uhrf1 ubiquitin-like with PHD and ring finger domains 10.0020599 1.73879 9.58E-05 2.42279 0.754702 1.04075 0.01684 1.45016

Mecom MDS1 and EVI1 complex locus0.0032763 4.79906 0.003861 4.58793 0.30448 1.51616 0.356445 1.44946

RGD1308195similar to secreted Ly6/uPAR related protein 20.0003748 -5.3361 0.001302 -3.96915 0.800979 1.07719 0.230517 1.44817

RGD1561367similar to Anillin 0.0015197 1.74195 1.46E-05 2.98885 0.187127 -1.18524 0.013802 1.44765

NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)3.22E-08 -4.61884 2.39E-05 -1.90672 0.000116 -1.67851 0.001135 1.44318

Ncaph non-SMC condensin I complex, subunit H0.0010801 1.69559 3.20E-05 2.42462 0.952227 1.00658 0.008895 1.43936

Nolc1 nucleolar and coiled-body phosphoprotein 11.16E-06 3.27128 1.99E-07 4.42937 0.523083 1.06275 0.003988 1.43898

Spag5 sperm associated antigen 50.0014637 1.93329 4.75E-05 3.00268 0.596286 -1.07973 0.030925 1.43846

Sf3b3 splicing factor 3b, subunit 30.0050418 1.35968 2.20E-05 2.02597 0.67166 -1.03595 0.001932 1.43832

App amyloid beta (A4) precursor protein0.0038857 -1.85421 0.001917 -2.00913 0.02057 1.55735 0.046189 1.43726

Ikzf2 IKAROS family zinc finger 20.817043 1.05378 0.72335 -1.08366 0.053807 1.6404 0.13689 1.4365

Lrmp lymphoid-restricted membrane protein0.0097619 1.50418 0.000295 2.08835 0.791727 1.03361 0.01752 1.43504

Car8 carbonic anhydrase 8 0.041005 1.70256 0.007353 2.18053 0.619886 1.11944 0.138126 1.43371

RGD1560691similar to calcium/calmodulin-dependent protein kinase 1D0.0037332 -1.54803 0.000209 -1.99812 0.000467 1.84764 0.010595 1.43144

Cx3cl1 chemokine (C-X3-C motif) ligand 10.0006455 -2.3852 0.000534 -2.44766 0.044676 1.46636 0.057401 1.42894

IgG-2a /// Igha /// LOC100360169 /// LOC100360329 /// LOC100360822 /// LOC100362271 /// LOC678969 /// LOC686380 /// RGD1565478gamma-2a immunoglobulin heavy chain /// immunoglobulin heavy chain, alpha /// rCG21044-0.945533 1.01358 0.831329 -1.04302 0.063519 1.50979 0.099621 1.42812

Psph phosphoserine phosphatase0.0032588 1.52463 5.04E-05 2.22361 0.833742 -1.02234 0.00824 1.42659

Ube2c ubiquitin-conjugating enzyme E2C3.71E-05 1.89945 3.37E-07 3.30773 0.031123 -1.22705 0.002095 1.41919

Sft2d3 SFT2 domain containing 30.412006 -1.1554 0.173369 -1.28334 0.026049 1.57587 0.069397 1.41877

Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 56.37E-07 8.67215 3.22E-07 10.5841 0.357542 1.16186 0.052672 1.41801

Sorbs2 sorbin and SH3 domain containing 20.0004091 -3.31316 7.22E-05 -4.67557 0.010041 2.00061 0.130024 1.41766

RT1-N3 RT1 class Ib, locus N3 0.0277917 1.78678 0.002027 2.64168 0.849809 -1.04322 0.145647 1.41721

Inpp5f inositol polyphosphate-5-phosphatase F0.0230248 -1.56946 0.01132 -1.69185 0.030087 1.52645 0.062338 1.41602

LOC500420 similar to CG12279-PA 3.53E-05 4.03542 2.37E-06 7.42606 0.159095 -1.30072 0.074611 1.41477

Trim59 tripartite motif-containing 590.0093813 1.49206 2.95E-05 2.70347 0.068748 -1.28079 0.018534 1.41468

Rad51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.0113004 1.48656 0.000321 2.06974 0.903964 1.0152 0.021249 1.41346

Fancd2 Fanconi anemia, complementation group D23.22E-05 1.94326 1.22E-06 2.79538 0.823661 -1.0185 0.002489 1.41237

of 148 Diabetes

Bysl bystin-like 0.0003774 1.6338 1.56E-05 2.16359 0.469639 1.06562 0.003376 1.41116

Mcm4 minichromosome maintenance complex component 40.0011934 1.65756 9.42E-05 2.09707 0.32579 1.11399 0.010425 1.40937

Krt19 keratin 19 0.0218837 2.81361 0.007973 3.59348 0.795687 1.10251 0.375272 1.4081

Orc1l origin recognition complex, subunit 1-like (yeast)0.0024721 2.23831 9.99E-05 3.74877 0.373434 -1.19117 0.103619 1.40604

Tspan5 tetraspanin 5 0.707653 1.06903 0.098626 -1.37839 0.002872 2.06824 0.083826 1.40358

Rrm2 ribonucleotide reductase M20.0005427 1.87145 4.07E-05 2.49079 0.651763 1.05438 0.017091 1.40332

Cdca8 cell division cycle associated 87.75E-05 2.03204 2.39E-06 3.11534 0.378661 -1.09363 0.00788 1.40186

Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide0.976056 1.00891 0.452253 -1.25416 0.080625 1.77358 0.272623 1.40167

Ccdc99 coiled-coil domain containing 994.16E-05 2.2689 5.56E-06 2.93388 0.466628 1.08084 0.011002 1.39762

Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 - 0.0024744 1.77454 4.20E-05 2.89455 0.273344 -1.16811 0.035402 1.39641

Ccna2 cyclin A2 8.61E-06 2.49512 1.90E-07 4.5021 0.022089 -1.29615 0.006868 1.39209

Snx8 sorting nexin 8 0.000134 -2.69116 0.000103 -2.79471 0.0348 1.44493 0.052238 1.39139

Nup85 nucleoporin 85 0.0003259 1.77091 1.50E-05 2.41905 0.852813 1.01844 0.00854 1.39119

Ccnd1 cyclin D1 1.61E-07 -2.8549 1.29E-06 -2.22823 0.230246 1.08454 0.00076 1.38955

Shcbp1 Shc SH2-domain binding protein 16.91E-06 3.65572 3.77E-07 6.66894 0.062532 -1.31358 0.031425 1.38876

RGD1564964similar to WD repeat domain 11 protein0.006451 -2.02244 0.002523 -2.30217 0.044982 1.58005 0.12726 1.38806

Birc5 baculoviral IAP repeat-containing 52.73E-05 2.32205 1.35E-06 3.51859 0.399961 -1.09168 0.010497 1.38803

Melk maternal embryonic leucine zipper kinase0.0102145 1.54387 6.96E-05 2.6494 0.139952 -1.23736 0.036025 1.38689

Tsga14 testis specific, 14 1.43E-06 -8.1125 7.79E-06 -5.33314 0.590625 -1.09716 0.083781 1.38644


Cenpk centromere protein K 0.0076396 1.48741 0.000112 2.19491 0.583064 -1.06628 0.020026 1.38393

Zwilch Zwilch, kinetochore associated, homolog (Drosophila)1.52E-05 2.45154 7.70E-07 3.78277 0.291909 -1.11567 0.010189 1.38304

Steap2 six transmembrane epithelial antigen of the prostate 20.000178 3.52735 0.001065 2.6119 0.011753 1.86765 0.130434 1.38294

Depdc1b DEP domain containing 1B0.0007497 1.75691 2.49E-05 2.5175 0.740659 -1.03728 0.016435 1.38141

Cdca2 cell division cycle associated 20.003806 1.7393 9.89E-05 2.66524 0.469016 -1.11013 0.047047 1.38035

Hmmr hyaluronan mediated motility receptor (RHAMM)0.0006039 2.25739 1.71E-05 3.88864 0.172254 -1.25066 0.064195 1.37737

Gins4 GINS complex subunit 4 (Sld5 homolog)3.66E-05 2.02814 1.67E-06 2.91361 0.638533 -1.043 0.005938 1.37736

Smc2 structural maintenance of chromosomes 20.0004976 1.71583 4.32E-06 2.85995 0.081602 -1.21077 0.010411 1.37665

Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.0002277 2.02094 9.20E-06 3.00744 0.496378 -1.08255 0.021192 1.37467

Gprc5b G protein-coupled receptor, family C, group 5, member B0.0131974 1.66086 0.001637 2.1061 0.629241 1.08365 0.082296 1.37415

Tox thymocyte selection-associated high mobility group box0.0006682 -2.96461 0.002855 -2.35575 0.680007 1.09042 0.156391 1.37225


Ect2 epithelial cell transforming sequence 2 oncogene0.0152784 1.60839 0.000218 2.67421 0.247976 -1.21253 0.075497 1.37124

Asph aspartate-beta-hydroxylase0.0016544 -2.54641 0.013977 -1.87786 0.957496 1.01113 0.155369 1.3711

Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.011163 1.85056 0.004213 2.09932 0.342401 1.2084 0.131136 1.37084

of 148Diabetes

Nup210 nucleoporin 210 0.0004517 2.21329 1.45E-05 3.65179 0.215362 -1.20607 0.054537 1.36803

H2afx H2A histone family, member X0.0011625 1.53511 9.17E-06 2.36799 0.204026 -1.12801 0.007048 1.3675

Bhlhe41 basic helix-loop-helix family, member e412.99E-06 -18.0302 1.59E-05 -10.1031 0.318672 -1.30699 0.251136 1.36544

Eef2k eukaryotic elongation factor-2 kinase6.44E-07 -2.2183 3.71E-06 -1.8845 0.031212 1.15959 0.000587 1.36498

Mark1 MAP/microtubule affinity-regulating kinase 10.0005133 1.74358 3.41E-05 2.27668 0.668854 1.0451 0.014042 1.36464

CCNF cyclin F 0.0027236 1.75522 7.07E-05 2.67886 0.418535 -1.11892 0.046231 1.36401

Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase1.74E-05 2.58003 3.10E-06 3.29895 0.557971 1.06592 0.018004 1.36293

Syne1 spectrin repeat containing, nuclear envelope 10.0014386 -2.05279 0.010726 -1.64959 0.566435 1.09468 0.075294 1.36224

Mybbp1a MYB binding protein (P160) 1a7.93E-05 2.10463 9.47E-06 2.70871 0.59442 1.05767 0.015827 1.36125

Pprc1 peroxisome proliferator-activated receptor gamma, coactivator-related 10.0002176 1.71267 3.58E-06 2.58151 0.257923 -1.10849 0.006643 1.35978

Cct8 chaperonin containing Tcp1, subunit 8 (theta)1.83E-06 1.98035 1.04E-07 2.68911 0.981076 1.00137 0.000567 1.35975

Tubb5 tubulin, beta 5 2.10E-07 2.57395 3.27E-08 3.31656 0.385009 1.05503 0.000758 1.35942

HMGA1 high mobility group AT-hook 11.03E-05 2.8713 1.46E-06 3.92134 0.961837 -1.00536 0.022173 1.35842

Gar1 GAR1 ribonucleoprotein homolog (yeast)8.81E-05 1.68609 3.69E-06 2.23681 0.759488 1.02309 0.002842 1.35726

Rbak RB-associated KRAB zinc finger0.0015855 -3.06181 0.004709 -2.52652 0.650065 1.11931 0.238223 1.35646

Ccdc34 coiled-coil domain containing 340.0668575 1.30302 0.000205 2.22891 0.100058 -1.26132 0.040572 1.35618

Ccnb2 cyclin B2 2.60E-05 2.23922 7.05E-07 3.6744 0.074968 -1.21157 0.011987 1.35438

Adssl1 adenylosuccinate synthase like 14.56E-05 4.55002 6.75E-06 7.13354 0.460213 -1.1593 0.151825 1.35237

E2f8 E2F transcription factor 81.92E-05 3.19971 5.58E-06 3.94786 0.504541 1.09497 0.04916 1.35099

Cxcl14 chemokine (C-X-C motif) ligand 141.54E-08 -45.9708 3.88E-08 -30.0865 0.483547 -1.13232 0.114419 1.34941

TSGA14 testis specific, 14 1.66E-06 -7.5157 9.94E-06 -4.91066 0.456632 -1.13557 0.103655 1.34777

Ppan peter pan homolog (Drosophila)0.0003731 1.71665 2.23E-05 2.24188 0.742019 1.03186 0.011845 1.34756

Nqo1 NAD(P)H dehydrogenase, quinone 16.58E-06 -2.75278 9.69E-06 -2.61538 0.035643 1.28007 0.015914 1.34732

Mrpl12 mitochondrial ribosomal protein L123.92E-05 1.89213 3.02E-06 2.46198 0.678088 1.0344 0.005368 1.34593

Cxcl10 chemokine (C-X-C motif) ligand 100.0293558 1.70567 0.002052 2.46875 0.719058 -1.07805 0.182184 1.34259

LOC100360406rCG34104-like 3.07E-05 1.86405 3.82E-06 2.28051 0.248718 1.09661 0.004154 1.34162

Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.0001438 2.31537 4.26E-05 2.71044 0.305072 1.14581 0.045671 1.34132


Csrp2 cysteine and glycine-rich protein 20.0037898 -2.70075 0.001964 -3.0438 0.133084 1.51016 0.269313 1.33995

LOC500700 similar to chromosome 14 open reading frame 1450.0041128 1.46216 1.67E-05 2.39542 0.068283 -1.22323 0.015731 1.33931

Ruvbl2 RuvB-like 2 (E. coli) 2.22E-06 2.09995 2.38E-07 2.69361 0.50963 1.04379 0.001543 1.33886

Shmt1 serine hydroxymethyltransferase 1 (soluble)8.02E-05 -2.01687 0.156705 -1.16094 0.025839 -1.29783 0.015722 1.3386

Tcea3 transcription elongation factor A (SII), 32.08E-07 -3.01938 3.08E-07 -2.85983 0.008487 1.26608 0.002746 1.33671

Kif2c kinesin family member 2C0.0603043 1.44367 0.000504 2.56631 0.127962 -1.33004 0.122466 1.33653

Id1 inhibitor of DNA binding 10.0005536 3.29982 0.000648 3.20684 0.178346 1.37506 0.216129 1.33632

of 148 Diabetes

RGD1565096Similar to TSG118.1 0.0057652 1.38298 3.27E-05 2.06095 0.24158 -1.11612 0.010418 1.33519

Ptgs1 prostaglandin-endoperoxide synthase 18.51E-05 2.36597 1.49E-06 4.42921 0.020956 -1.40326 0.04067 1.33407

Ptafr platelet-activating factor receptor0.0017266 1.45382 5.30E-06 2.37242 0.037678 -1.22358 0.007517 1.33366

LOC500013 similar to sterile alpha motif domain containing 9-like0.0074447 -2.26055 0.707158 -1.09342 0.092262 -1.55041 0.245013 1.33346


Hs3st3b1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 [1.71E-07 -25.1609 5.48E-07 -16.0661 0.426493 -1.17619 0.177671 1.33149

RGD1308396similar to chromosome 14 open reading frame 210.0009064 1.83456 4.01E-05 2.60996 0.590277 -1.06872 0.042236 1.33119

Steap1 six transmembrane epithelial antigen of the prostate 10.0002443 4.00241 0.001449 2.86554 0.023442 1.85764 0.234358 1.32998

Polr1e polymerase (RNA) I polypeptide E0.0001917 1.86088 1.12E-05 2.51802 0.859172 -1.01771 0.017783 1.32959

Aaas achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)4.70E-05 1.82996 6.93E-07 2.88896 0.054386 -1.18751 0.005776 1.32942

LOC100912041uncharacterized LOC1009120410.0058625 1.65695 0.000328 2.25358 0.869074 -1.02337 0.069365 1.32903

Chaf1b chromatin assembly factor 1, subunit B (p60)0.007694 1.50044 0.000236 2.05841 0.788282 -1.0324 0.038377 1.32881

Casp4 caspase 4, apoptosis-related cysteine peptidase0.0038272 2.22414 0.008517 1.99049 0.082166 1.48414 0.191042 1.32823

Tars threonyl-tRNA synthetase2.89E-06 2.25556 1.26E-06 2.47621 0.027033 1.20975 0.003815 1.32809

LOC100910632uncharacterized LOC1009106321.84E-05 -2.69815 8.32E-05 -2.23728 0.411077 1.10026 0.033272 1.32691

Ccnd1 cyclin D1 3.27E-06 -2.43412 4.65E-05 -1.86168 0.855647 1.01483 0.00689 1.32688

Ttk Ttk protein kinase 0.0003021 1.99176 1.01E-05 3.03669 0.255819 -1.14927 0.037746 1.3266

Cenpn centromere protein N 3.17E-05 2.01055 2.81E-06 2.63115 0.886711 1.01236 0.009819 1.32485

POLE polymerase (DNA directed), epsilon0.0022886 1.62148 0.000122 2.13914 0.97087 1.00415 0.03367 1.32473

Aldh18a1 aldehyde dehydrogenase 18 family, member A12.68E-05 2.28568 1.54E-05 2.43832 0.055355 1.24168 0.019589 1.3246

Znf593 zinc finger protein 593 1.13E-05 2.14819 4.56E-07 3.20826 0.16918 -1.12753 0.007634 1.32455

Tubb5 tubulin, beta 5 0.0004259 1.80154 2.45E-05 2.42535 0.874721 -1.01679 0.02526 1.32404

Dhrs1 dehydrogenase/reductase (SDR family) member 12.32E-07 3.746 1.91E-07 3.87367 0.017231 1.2801 0.009357 1.32373


LOC498872 similar to MGC108823 protein0.291482 1.98527 0.102405 3.06411 0.806041 -1.16663 0.657127 1.32297

Vrk1 vaccinia related kinase 10.0006953 1.52922 1.65E-05 2.06925 0.779543 -1.0233 0.007943 1.32233

LOC304558 similar to TPR repeat-containing protein KIAA10439.89E-05 -2.47159 0.000347 -2.12428 0.343469 1.13628 0.058969 1.32205

Ndufaf4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.0008298 1.54099 1.97E-05 2.10275 0.709896 -1.03263 0.010127 1.32143

Cks2 CDC28 protein kinase regulatory subunit 22.63E-05 2.07425 1.72E-06 2.85859 0.630814 -1.0434 0.011324 1.32081

Gria2 glutamate receptor, ionotropic, AMPA 20.0004814 -3.56479 0.000213 -4.20557 0.084469 1.55734 0.252127 1.32006

Hspa4 heat shock protein 4 0.0120973 1.35361 0.152036 1.1601 0.001748 1.54006 0.018178 1.31989

Ccnb1 cyclin B1 1.54E-06 3.04344 9.17E-08 4.96374 0.044079 -1.2362 0.014245 1.31933

Atp2a3 ATPase, Ca++ transporting, ubiquitous0.0008806 -2.42044 0.003776 -1.99945 0.632464 1.08918 0.14626 1.31851

Foxm1 forkhead box M1 0.0003241 1.8948 2.63E-05 2.49426 0.99057 1.0013 0.032018 1.31808

Hist3h2ba histone cluster 3, H2ba0.0257804 1.40968 0.000199 2.24816 0.165974 -1.21117 0.06001 1.31674

of 148Diabetes

Aurkb aurora kinase B 1.63E-05 2.01251 7.31E-07 2.86931 0.326879 -1.08299 0.006965 1.31648

Cks1b CDC28 protein kinase regulatory subunit 1B3.87E-05 1.85343 3.88E-06 2.32048 0.535766 1.0503 0.006884 1.31497

Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 10.0006719 -1.49974 5.93E-06 -2.20825 2.28E-05 1.93612 0.006728 1.31492

Snrpa small nuclear ribonucleoprotein polypeptide A9.32E-05 1.83148 5.43E-06 2.44295 0.866701 -1.01469 0.011693 1.31456

Peli2 Pellino 2 0.0016463 -2.52597 0.000807 -2.82761 0.088799 1.47108 0.207694 1.31415

Il33 interleukin 33 1.62E-05 6.59133 0.000146 4.00617 0.005685 2.16 0.222481 1.31283

Trim14 tripartite motif-containing 149.75E-06 -3.58377 8.01E-05 -2.60019 0.717091 -1.05003 0.069832 1.3126

Pop1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)6.99E-05 1.90483 3.19E-06 2.66398 0.481542 -1.06556 0.013375 1.3125

Zfp462 zinc finger protein 462 3.10E-06 -4.57433 5.60E-06 -4.0793 0.270995 1.17031 0.075262 1.31233

FHOD3 formin homology 2 domain containing 31.13E-08 -27.2126 2.70E-08 -19.2794 0.614093 -1.07643 0.089714 1.31126

Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) /// Low affinity immunoglobulin g1.56E-06 14.101 4.63E-07 22.1926 0.413115 -1.20042 0.236434 1.31106

Rrs1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)5.85E-05 1.68755 7.22E-07 2.56582 0.060477 -1.16045 0.004145 1.31021

Nup160 nucleoporin 160 0.0006794 1.65002 3.73E-05 2.14758 0.945421 1.00662 0.020187 1.31017

Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 217.52E-05 1.72899 4.26E-06 2.24691 0.920777 1.00761 0.006491 1.30944

Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 21.59E-07 -2.22463 2.37E-06 -1.75619 0.505816 1.03368 0.000471 1.3094

Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 21.59E-07 -2.22463 2.37E-06 -1.75619 0.505816 1.03368 0.000471 1.3094

Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 37.79E-07 -6.03206 4.15E-06 -4.23455 0.531188 -1.08967 0.075455 1.30726

Umps uridine monophosphate synthetase0.0006072 1.65763 1.57E-05 2.34688 0.4135 -1.08324 0.020247 1.30702

Stip1 stress-induced phosphoprotein 10.0011038 1.76492 7.91E-05 2.32275 0.944276 -1.00829 0.048396 1.30525

Nup93 nucleoporin 93 7.19E-06 2.2239 1.17E-06 2.75931 0.539911 1.05132 0.009365 1.30443

Gpatch4 G patch domain containing 40.0004224 1.79463 1.05E-05 2.67957 0.219377 -1.14478 0.030739 1.30428

Shmt2 serine hydroxymethyltransferase 2 (mitochondrial)0.0002582 1.8662 2.63E-05 2.36986 0.809361 1.02539 0.0304 1.30213

Traip TRAF-interacting protein0.0077098 1.53802 0.00019 2.20574 0.449293 -1.10181 0.062521 1.30162

Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast)0.0001428 2.21212 3.41E-06 3.76148 0.05206 -1.3068 0.055121 1.3012

Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.0001697 1.81876 4.47E-06 2.68419 0.192206 -1.13781 0.02085 1.29708

Akr1c14 aldo-keto reductase family 1, member C140.000534 -6.08727 0.000588 -5.92866 0.493367 1.26251 0.44737 1.29629

Bcl3 B-cell CLL/lymphoma 30.0198691 1.64696 0.00341 2.02628 0.772282 1.05284 0.170889 1.29532

Whsc1 Wolf-Hirschhorn syndrome candidate 1 (human)1.78E-05 3.24159 3.97E-06 4.21053 0.981303 -1.00315 0.081954 1.29483

Cxxc5 CXXC finger 5 0.0002131 -2.24814 0.000872 -1.92304 0.444464 1.10748 0.076272 1.29471

LOC100912749uncharacterized LOC1009127491.96E-05 3.72027 6.36E-06 4.61396 0.779043 1.04362 0.117576 1.29432

Chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)3.21E-05 2.03957 1.31E-06 2.98329 0.18926 -1.13033 0.016582 1.29406

Mca32 mast cell antigen 32 2.20E-05 -6.54685 0.000113 -4.45941 0.570118 -1.13487 0.262693 1.29362

LOC360228 WDNM1 homolog 0.564838 1.22721 0.026761 2.51742 0.213242 -1.58588 0.472045 1.2935

Sdad1 SDA1 domain containing 12.13E-06 1.95877 2.92E-07 2.38659 0.32627 1.06027 0.001813 1.29185

Taf1d TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa9.26E-06 2.53976 1.20E-06 3.39007 0.732063 -1.034 0.026748 1.29091

of 148 Diabetes

Akr1c14 aldo-keto reductase family 1, member C143.66E-05 -5.62856 2.83E-05 -5.98876 0.170927 1.37299 0.260854 1.29041

Nip7 nuclear import 7 homolog (S. cerevisiae)0.0002024 1.58629 4.71E-06 2.1731 0.427918 -1.06174 0.007489 1.29025

Mms22l MMS22-like, DNA repair protein0.0002908 2.17292 8.35E-05 2.5345 0.451187 1.10609 0.080382 1.29015

KIFC2 kinesin family member C28.69E-06 -3.64105 2.73E-05 -3.02389 0.610599 1.0711 0.08532 1.28971


Itga11 integrin, alpha 11 9.56E-05 -1.78136 1.97E-05 -2.05265 0.001181 1.48514 0.01361 1.28886

Pnpla3 patatin-like phospholipase domain containing 31.07E-06 -4.39091 8.70E-07 -4.57025 0.031188 1.34135 0.054297 1.28871

Trmt61a tRNA methyltransferase 61 homolog A (S. cerevisiae)0.0001105 1.61959 1.97E-06 2.30103 0.189089 -1.10363 0.006248 1.28734

Trip13 thyroid hormone receptor interactor 133.63E-05 2.19439 3.53E-06 2.93322 0.704198 -1.0384 0.02983 1.28726

Ebna1bp2 EBNA1 binding protein 23.07E-05 1.89164 3.18E-06 2.37409 0.751758 1.02516 0.010531 1.28663


Cdc20 cell division cycle 20 homolog (S. cerevisiae)0.0132156 1.27184 1.59E-05 2.00827 0.026139 -1.2295 0.010904 1.28428

IGF2BP2 insulin-like growth factor 2 mRNA binding protein 25.36E-08 14.9662 2.89E-08 18.6767 0.845079 1.02868 0.112476 1.28372

Cadm1 cell adhesion molecule 19.40E-05 -2.22908 0.000161 -2.10001 0.127647 1.20885 0.05595 1.28315

Ppat phosphoribosyl pyrophosphate amidotransferase0.0022592 1.64345 3.82E-05 2.50478 0.165067 -1.18786 0.05789 1.28307

LOC100362121damage specific DNA binding protein 24.89E-05 -2.16995 0.00036 -1.78756 0.591492 1.05653 0.035295 1.28255

Mcm10 minichromosome maintenance complex component 100.003125 1.81133 9.10E-05 2.79621 0.228521 -1.20417 0.119414 1.28199

Gmps guanine monphosphate synthetase4.43E-06 1.79973 4.37E-07 2.21548 0.488592 1.0399 0.001797 1.28012

Pak1ip1 PAK1 interacting protein 13.55E-05 2.19156 2.68E-06 3.03622 0.427178 -1.08297 0.032383 1.27928

Ssr1 signal sequence receptor, alpha2.76E-05 1.91596 2.52E-06 2.44963 0.997696 -1.00023 0.012264 1.27825

Rac1 Ras-related C3 botulinum toxin substrate 10.0341235 1.448 0.463985 -1.11806 0.00104 2.06878 0.129578 1.27786

LOC100912578stress-70 protein, mitochondrial-like7.08E-06 1.68168 4.48E-07 2.10942 0.725938 1.01859 0.001305 1.27767

Zfp395 zinc finger protein 395 0.0001254 -2.19118 0.000478 -1.9037 0.386187 1.10994 0.063545 1.27756

Id3 inhibitor of DNA binding 35.95E-07 44.6014 3.98E-07 54.607 0.877747 1.04345 0.387121 1.27753

Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 20.0016449 -2.1629 0.016562 -1.65041 0.881412 -1.02588 0.178192 1.27746

SIX3 SIX homeobox 3 0.0019019 -1.92432 0.000417 -2.29946 0.0192 1.52432 0.129872 1.27563

Clspn claspin homolog (Xenopus laevis)0.0006463 2.033 0.00047 2.10672 0.152462 1.23095 0.101104 1.27559

Ear11 eosinophil-associated, ribonuclease A family, member 110.0268546 1.76985 0.003878 2.33245 0.879369 -1.03362 0.282869 1.27501


Sorbs1 sorbin and SH3 domain containing 10.0058189 -1.27056 0.000191 -1.51694 0.000182 1.52166 0.00543 1.27451

Tk1 thymidine kinase 1, soluble0.0007897 1.94841 5.56E-05 2.68035 0.560401 -1.0805 0.094714 1.27317

Nop56 NOP56 ribonucleoprotein homolog (yeast)1.01E-05 2.02817 2.04E-06 2.39672 0.341608 1.07592 0.010573 1.27143

LOC100310874antisense RNA overlapping MCH0.027345 1.57853 0.000771 2.43573 0.286084 -1.21375 0.1944 1.2713

Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit)0.003785 1.83486 0.000728 2.22155 0.754268 1.05 0.149632 1.27128

Map4k4 mitogen-activated protein kinase kinase kinase kinase 40.0011464 2.47974 0.003891 2.09281 0.057094 1.50524 0.229914 1.27037

of 148Diabetes

Nmral1 NmrA-like family domain containing 10.0018443 1.83937 0.000134 2.48815 0.650246 -1.06493 0.111117 1.27024

Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 48.06E-05 -4.24477 0.000409 -3.12853 0.741909 -1.06945 0.261334 1.26869


Timm9 translocase of inner mitochondrial membrane 9 homolog (yeast)7.59E-05 1.78256 6.65E-06 2.24052 0.912117 1.00893 0.016002 1.26814

Cirh1a cirrhosis, autosomal recessive 1A5.76E-05 1.5799 1.03E-06 2.19179 0.168788 -1.09406 0.003971 1.26803

Ccdc125 coiled-coil domain containing 1250.0034312 3.59178 0.005042 3.29687 0.330855 1.38089 0.468841 1.26751

SH3RF2 SH3 domain containing ring finger 20.0030775 -5.12895 0.009963 -3.71803 0.831619 -1.08971 0.563249 1.26591

Ascl2 achaete-scute complex homolog 2 (Drosophila)5.37E-06 -5.8054 2.13E-05 -4.30891 0.713508 -1.06497 0.19304 1.2651

CNTN3 contactin 3 (plasmacytoma associated)0.0001038 -3.60698 0.000352 -2.92413 0.895026 1.02498 0.231487 1.26433

Arg2 arginase type II 3.69E-06 -2.42881 1.34E-05 -2.10995 0.27185 1.09827 0.018368 1.26424

Incenp inner centromere protein0.0050402 1.71147 0.000948 2.04211 0.699142 1.05787 0.135787 1.26224

Rrm2 ribonucleotide reductase M25.60E-05 2.30755 3.31E-06 3.40863 0.182584 -1.17108 0.064205 1.26137

Rrp15 ribosomal RNA processing 15 homolog (S. cerevisiae)0.0002919 1.92135 3.44E-05 2.42602 0.991933 -1.00112 0.062259 1.26125

Pttg1 pituitary tumor-transforming 18.73E-05 1.93588 3.93E-06 2.74091 0.237246 -1.12328 0.034504 1.26047

Nap1l1 Nucleosome assembly protein 1-like 11.54E-05 1.85958 2.12E-06 2.2434 0.53327 1.04475 0.008801 1.26038

Cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family)1.39E-06 1.80606 1.17E-07 2.25604 0.860752 1.00847 0.001106 1.25972

Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 16.97E-05 -3.11267 0.000142 -2.78945 0.447981 1.1285 0.166644 1.25927

Ezh2 enhancer of zeste homolog 2 (Drosophila)9.00E-05 1.66065 2.81E-06 2.25385 0.314735 -1.07817 0.011188 1.25881

Tp53 tumor protein p53 6.00E-06 1.66307 4.12E-07 2.05901 0.74663 1.01637 0.001478 1.25835

Luc7l3 LUC7-like 3 (S. cerevisiae)0.336249 1.1659 0.755089 -1.04963 0.020761 1.53871 0.165454 1.25736

Alad aminolevulinate, delta-, dehydratase7.51E-07 -3.30956 3.80E-06 -2.63261 0.995749 -1.00048 0.030392 1.25654

Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.0013218 2.41458 0.001029 2.50408 0.324824 1.21151 0.247314 1.25641

Tlcd1 TLC domain containing 10.0003555 -2.26405 0.001783 -1.88473 0.754437 1.04574 0.137315 1.2562

Vars valyl-tRNA synthetase 1.13E-06 2.08379 4.16E-07 2.30695 0.055964 1.13396 0.003728 1.2554

Anapc1 anaphase promoting complex subunit 10.0029683 1.79784 0.000592 2.14503 0.725609 1.052 0.141777 1.25515

Bid BH3 interacting domain death agonist0.0002764 2.56693 4.61E-05 3.38286 0.758361 -1.05008 0.177149 1.25502

Rxrg retinoid X receptor gamma0.0002679 -2.30209 0.029473 -1.42966 0.102027 -1.28339 0.131676 1.25467

Il12a interleukin 12a 2.19E-06 -2.80154 2.35E-05 -2.11659 0.551127 -1.05502 0.029945 1.25459

Ppp2r5b protein phosphatase 2, regulatory subunit B', beta isoform1.02E-06 -2.39247 1.29E-05 -1.86593 0.743872 -1.02257 0.008965 1.25389

Fgfr3 Fibroblast growth factor receptor 33.15E-06 -2.33932 9.71E-06 -2.07847 0.187062 1.11347 0.016314 1.25321

Cdca3 cell division cycle associated 30.0003357 1.8978 6.75E-06 3.026 0.054529 -1.27336 0.069553 1.25218

Acot1 acyl-CoA thioesterase 10.0016417 -3.19791 0.001569 -3.22585 0.381556 1.26038 0.398865 1.24946

SLC16A12 solute carrier family 16, member 12 (monocarboxylic acid transporter 12)1.09E-07 -18.2272 4.50E-07 -11.2327 0.150499 -1.29894 0.21309 1.24924


Ubap2 ubiquitin-associated protein 26.55E-06 1.62721 3.84E-07 2.02552 0.953218 1.00285 0.00151 1.24833

of 148 Diabetes

Tnnt2 troponin T type 2 (cardiac)0.0010475 2.9669 0.000519 3.36656 0.672335 1.10009 0.3374 1.24828

Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) /// Fc gamma receptor II beta6.72E-06 12.1237 2.99E-06 16.0802 0.807813 -1.06269 0.386221 1.24811

LOC679127 similar to Protein KIAA06900.003173 1.52473 9.69E-05 2.06575 0.439123 -1.08609 0.060908 1.24744

Gm2a GM2 ganglioside activator2.38E-05 2.06119 7.77E-06 2.31958 0.251015 1.10837 0.028902 1.24731

Nrg1 neuregulin 1 0.000456 2.77037 1.30E-05 5.41117 0.036366 -1.56669 0.252622 1.24672

Nlk Nemo like kinase 2.41E-05 -2.27216 6.30E-05 -2.05125 0.24708 1.12528 0.048105 1.24647

Iqgap3 IQ motif containing GTPase activating protein 30.0001779 2.27953 8.07E-06 3.54604 0.115506 -1.24853 0.118439 1.24595


Snhg4 small nucleolar RNA host gene 4 (non-protein coding)0.0008814 2.20299 0.000878 2.20411 0.192574 1.2442 0.191652 1.24483

C1qbp complement component 1, q subcomponent binding protein2.78E-06 2.07061 5.55E-07 2.455 0.464601 1.04937 0.008304 1.24418

Mxra7 matrix-remodelling associated 72.31E-05 -2.07926 2.74E-05 -2.0445 0.043355 1.22259 0.031695 1.24338

Eif4g1 eukaryotic translation initiation factor 4 gamma, 10.0007031 1.79095 0.000178 2.04783 0.465601 1.08738 0.081535 1.24335

Cdkn3 cyclin-dependent kinase inhibitor 30.0003365 1.66099 1.14E-05 2.26625 0.304893 -1.09774 0.033849 1.24291

Klk10 kallikrein related-peptidase 100.0687113 3.09107 0.026328 4.30246 0.836721 -1.12109 0.697477 1.24156

Prmt5 protein arginine methyltransferase 50.0002905 1.57311 8.11E-06 2.11205 0.322335 -1.08153 0.019598 1.24138

C1s complement component 1, s subcomponent1.40E-05 10.3356 6.81E-06 13.106 0.928252 -1.02348 0.416031 1.23894

Pbk PDZ binding kinase 0.0008668 1.93773 3.21E-05 2.91772 0.166564 -1.21556 0.133673 1.23873

Kif2c kinesin family member 2C0.0014215 1.6793 4.00E-05 2.4144 0.206985 -1.16118 0.085279 1.23817

Lyar Ly1 antibody reactive homolog (mouse)9.72E-05 1.88761 8.60E-06 2.42808 0.673891 -1.03957 0.043394 1.23737

Lims2 LIM and senescent cell antigen like domains 20.0024377 -1.82032 9.60E-05 -2.67946 0.002435 1.8205 0.161156 1.23678

Ftsj3 FtsJ homolog 3 (E. coli) 2.06E-05 1.65007 1.22E-06 2.07341 0.785552 -1.01601 0.005518 1.23675

LOC680531 similar to CG3880-PA 4.61E-07 5.61279 9.27E-08 8.32968 0.159402 -1.20033 0.109091 1.23637

Crct1 cysteine-rich C-terminal 10.0518479 13.2148 0.092713 8.65716 0.590768 1.88386 0.857046 1.23414

Ska3 spindle and kinetochore associated complex subunit 36.47E-06 -2.70226 6.23E-06 -2.71572 0.05504 1.24006 0.059673 1.23392

Ska3 spindle and kinetochore associated complex subunit 36.47E-06 -2.70226 6.23E-06 -2.71572 0.05504 1.24006 0.059673 1.23392

Ncl nucleolin 3.05E-06 1.91051 3.77E-07 2.34007 0.903865 1.00707 0.005931 1.2335

Zcchc11 zinc finger, CCHC domain containing 117.96E-05 -3.23561 0.000696 -2.34522 0.502756 -1.11856 0.225312 1.23342

Isg15 ISG15 ubiquitin-like modifier0.558382 -1.34195 0.213322 1.91794 0.164897 -2.08808 0.675626 1.2326

Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 30.0011555 2.26614 0.00056 2.50148 0.525463 1.11656 0.243608 1.23251

Mgst2 microsomal glutathione S-transferase 24.37E-05 4.84183 4.91E-05 4.72027 0.271968 1.26191 0.324029 1.23023

SYNPO2 synaptopodin 2 0.858086 -1.19426 0.345565 -2.62094 0.331931 2.69888 0.835034 1.22978

Casc4 cancer susceptibility candidate 40.0003242 3.34818 0.00011 4.11498 0.999191 1.00021 0.335553 1.22928

Ltb4r leukotriene B4 receptor0.0003513 2.24758 0.000171 2.46083 0.422236 1.12253 0.169709 1.22904

Ns5atp9 NS5A (hepatitis C virus) transactivated protein 99.12E-06 2.29443 8.05E-07 3.13765 0.238183 -1.11281 0.039454 1.22887

Lrg1 leucine-rich alpha-2-glycoprotein 10.0006685 2.99113 0.000153 3.92251 0.756842 -1.06755 0.342735 1.2284

of 148Diabetes

RGD1564927similar to TGFB-induced factor 20.0330182 1.36949 0.000317 2.08706 0.115216 -1.24111 0.131571 1.22791

Ocm oncomodulin 0.0006588 2.73137 0.000277 3.14602 0.74113 1.06592 0.303616 1.22774

Cryba1 crystallin, beta A1 0.0620341 -5.42951 0.458416 -1.83667 0.292724 -2.40839 0.799507 1.22745

Fjx1 four jointed box 1 (Drosophila)3.36E-05 -4.87391 0.000119 -3.76224 0.783161 -1.05584 0.315195 1.22697

Hlf hepatic leukemia factor /// similar to hepatic leukemia factor9.23E-06 -2.30004 0.000695 -1.56796 0.066084 -1.19624 0.041761 1.22626

Atp2b1 ATPase, Ca++ transporting, plasma membrane 10.0006594 1.87144 0.014603 1.43513 0.003794 1.5985 0.118449 1.22582

Ldhb lactate dehydrogenase B3.87E-05 -2.19347 3.88E-05 -2.19268 0.068407 1.22533 0.06801 1.22578

Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast)0.0004762 -2.23857 0.00177 -1.9234 0.726865 1.05287 0.191282 1.22539

LOC691153 Hypothetical protein LOC6911535.35E-06 -2.51033 5.88E-05 -1.94312 0.558347 -1.05428 0.046786 1.22539

Ipo4 importin 4 1.52E-06 2.08411 2.41E-07 2.54106 0.938245 1.00469 0.008472 1.22497

Tet3 tet oncogene family member 31.53E-06 -2.03831 1.56E-05 -1.68685 0.819466 1.01348 0.007297 1.22464

Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.000266 1.69521 3.43E-05 2.02769 0.802347 1.02236 0.046343 1.22287

Chrm3 cholinergic receptor, muscarinic 30.0001854 -3.44153 8.41E-05 -3.99283 0.102978 1.41793 0.321244 1.22215

Gnl3 guanine nucleotide binding protein-like 3 (nucleolar)8.84E-06 1.93726 1.05E-06 2.40167 0.829176 -1.01493 0.016843 1.22148

Aqp5 aquaporin 5 0.0001377 -3.94865 0.00036 -3.29442 0.929363 1.01865 0.351874 1.22094

Iah1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)3.63E-07 -2.78393 1.72E-06 -2.30841 0.861903 1.01224 0.01858 1.22076

Ccdc8 coiled-coil domain containing 80.000122 3.69927 0.000152 3.55105 0.239516 1.27152 0.322484 1.22057

Eef2k Eukaryotic elongation factor-2 kinase0.0273152 -1.92262 0.008784 -2.30566 0.156514 1.46139 0.438717 1.21861

Slfn8 schlafen 8 0.0003864 2.4419 5.79E-05 3.23996 0.590569 -1.08941 0.233098 1.21792

Mrps27 Mitochondrial ribosomal protein S270.0006278 1.74208 3.55E-05 2.32241 0.39735 -1.09582 0.091762 1.21655

Sec14l3 SEC14-like 3 (S. cerevisiae)1.57E-07 -12.1911 1.16E-07 -13.4581 0.082874 1.34231 0.224654 1.21594

Etv5 ets variant 5 0.0003562 -2.78746 0.002716 -2.09719 0.618851 -1.09384 0.293633 1.21511

LOC100912383uncharacterized LOC1009123830.0931879 -1.1961 5.75E-05 -2.06157 4.94E-05 2.09378 0.072189 1.21479

Fat2 FAT tumor suppressor homolog 2 (Drosophila)1.40E-07 2.36519 2.19E-07 2.25446 0.00137 1.27309 0.004945 1.21349

Osr2 odd-skipped related 2 (Drosophila)0.0001493 3.46211 8.97E-05 3.80347 0.605885 1.1043 0.326143 1.21318

Sfxn1 sideroflexin 1 2.99E-05 1.74899 1.14E-06 2.37416 0.12373 -1.12083 0.02025 1.21111

Fam189a2 family with sequence similarity 189, member A28.29E-05 -2.36225 0.002509 -1.66389 0.212319 -1.17274 0.142692 1.2106

Tmem176a transmembrane protein 176A5.80E-05 -2.02208 0.000373 -1.712 0.800898 1.02416 0.071251 1.20965

Plekha6 Pleckstrin homology domain containing, family A member 62.74E-07 -2.02388 1.97E-06 -1.72589 0.511447 1.03139 0.002885 1.20947

Timm10 translocase of inner mitochondrial membrane 10 homolog (yeast)0.0006744 1.51423 1.74E-05 2.01808 0.243269 -1.10235 0.039701 1.20901

LOC304558 similar to TPR repeat-containing protein KIAA10431.08E-06 -2.79777 8.52E-07 -2.88983 0.022038 1.24871 0.041831 1.20893

Cenpw centromere protein W 0.0011769 1.61693 1.39E-05 2.49882 0.036287 -1.27855 0.088687 1.20873

Apc2 adenomatosis polyposis coli 24.84E-05 -6.0509 0.000155 -4.60107 0.719563 -1.08861 0.431625 1.20806

Trmt6 tRNA methyltransferase 6 homolog (S. cerevisiae)1.43E-05 1.91898 1.53E-06 2.40522 0.609124 -1.03792 0.02721 1.20759

Mis18a MIS18 kinetochore protein homolog A (S. pombe)2.04E-05 2.44843 0.000942 1.67024 0.000473 1.76993 0.09843 1.20738

of 148 Diabetes

Atf5 activating transcription factor 50.0001309 2.20802 2.61E-05 2.69905 0.916432 -1.0126 0.142089 1.20718

Ampd3 adenosine monophosphate deaminase 33.21E-05 2.08712 2.22E-05 2.16812 0.126734 1.16207 0.065151 1.20717

Fbp2 fructose-1,6-bisphosphatase 20.0029865 -2.10133 8.08E-05 -3.6574 0.00299 2.10106 0.317783 1.20715

Ptrh2 peptidyl-tRNA hydrolase 24.76E-05 1.60351 2.71E-06 2.00412 0.574156 -1.03562 0.013656 1.20685

Per3 period homolog 3 (Drosophila)0.0004246 -2.40396 0.00017 -2.73036 0.072565 1.37 0.253249 1.20623

Rabggtb Rab geranylgeranyltransferase, beta subunit5.41E-07 1.98582 1.77E-07 2.20848 0.128079 1.08447 0.004409 1.20607

Antxr1 anthrax toxin receptor 10.0001898 -2.1483 0.001199 -1.78033 0.996113 -1.00059 0.150529 1.20597

Tomm70a translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)4.89E-05 1.69224 2.11E-06 2.23286 0.21391 -1.09438 0.023196 1.20568

RGD1305592similar to RIKEN cDNA 2900092E175.79E-06 1.70555 3.07E-07 2.18916 0.251463 -1.06471 0.006173 1.20554

Ccne1 cyclin E1 1.65E-05 2.71843 1.94E-06 3.78152 0.227038 -1.15392 0.125965 1.20551

C3 complement component 30.0041071 3.2195 0.000747 4.73047 0.519618 -1.21927 0.543943 1.20508

Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 26.36E-05 -2.24393 0.00046 -1.83278 0.884975 -1.01603 0.117993 1.20501

Sephs1 selenophosphate synthetase 12.46E-05 -2.29713 9.65E-05 -1.98848 0.673047 1.04296 0.08833 1.20484

Bmp6 Bone morphogenetic protein 60.0007253 -2.3594 0.00018 -2.88262 0.044012 1.47177 0.283269 1.20463

TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)4.31E-05 1.83067 3.34E-06 2.34859 0.426507 -1.06524 0.039031 1.20435

Ptbp1 polypyrimidine tract binding protein 11.99E-05 1.63432 1.15E-06 2.05007 0.475159 -1.04217 0.009898 1.20363

NFIB nuclear factor I/B 5.45E-05 1.93513 1.83E-05 2.15404 0.385933 1.08118 0.061226 1.20349

Il33 interleukin 33 6.36E-05 7.1143 0.000362 4.59472 0.043078 1.86024 0.497891 1.20142

Gars glycyl-tRNA synthetase 2.06E-07 2.16824 8.11E-08 2.39146 0.110341 1.08921 0.00485 1.20134

Flna filamin A, alpha 2.64E-06 2.69381 1.71E-06 2.855 0.183196 1.1316 0.064576 1.19931

CADM1 cell adhesion molecule 11.88E-06 -5.03505 5.61E-06 -4.05407 0.796654 -1.03592 0.207988 1.19891

RGD1566102RGD1566102 0.0026221 2.4022 0.00544 2.15836 0.19494 1.3343 0.399677 1.19886

Dsn1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)0.0013491 1.71267 6.87E-05 2.31869 0.307337 -1.12989 0.145084 1.19822

Phf15 PHD finger protein 15 9.01E-05 -2.00036 0.000156 -1.89786 0.218828 1.13658 0.096529 1.19797

Phf15 PHD finger protein 15 9.01E-05 -2.00036 0.000156 -1.89786 0.218828 1.13658 0.096529 1.19797

HAUS6 HAUS augmin-like complex, subunit 60.0011852 1.8237 0.000267 2.12973 0.841498 1.02563 0.178951 1.19773

Pola1 polymerase (DNA directed), alpha 10.0039155 1.6926 0.000234 2.28617 0.386985 -1.1277 0.206859 1.19772

LOC100361467hypothetical LOC1003614675.03E-05 4.36133 8.33E-05 3.94353 0.173069 1.32427 0.365402 1.19741

Pkmyt1 protein kinase, membrane associated tyrosine/threonine 10.0034554 1.70456 0.000542 2.05935 0.946145 -1.00912 0.204147 1.19723

Pitrm1 pitrilysin metallopeptidase 16.15E-05 1.91767 8.05E-06 2.36255 0.736204 -1.03023 0.069475 1.19584

Mmp14 Matrix metallopeptidase 14 (membrane-inserted)0.0005308 2.19815 0.000307 2.35324 0.457604 1.11676 0.242408 1.19555

LOC691700 similar to heparan sulfate D-glucosaminyl 3-O-sulfotransferase 40.0024423 -3.25167 0.230242 -1.42185 0.043443 -1.91434 0.530113 1.19464

LOC500013 /// LOC680260 /// RGD1561472 /// Samd9lsimilar to sterile alpha motif domain containing 9-like /// similar to sterile alpha mo0.0008223 -2.88263 0.027096 -1.73254 0.141943 -1.39329 0.408835 1.19416

Acot1 /// Acot2acyl-CoA thioesterase 1 /// acyl-CoA thioesterase 25.63E-05 -2.0137 0.000126 -1.8671 0.2948 1.10697 0.086353 1.19389

Donson downstream neighbor of SON4.16E-05 2.5133 1.52E-05 2.88102 0.7315 1.04151 0.160082 1.19389

of 148Diabetes

Tyms thymidylate synthetase0.0094381 1.85937 0.000353 2.95024 0.157308 -1.3299 0.362236 1.19309

Suv39h1 suppressor of variegation 3-9 homolog 1 (Drosophila)0.0002353 1.64786 2.07E-05 2.02214 0.721485 -1.02976 0.058236 1.19166

LOC100911266uncharacterized LOC1009112660.0090882 1.78302 0.000883 2.38581 0.51201 -1.12303 0.330459 1.19149

Cuedc2 CUE domain containing 20.0002891 1.95454 0.0001 2.18533 0.590352 1.06352 0.153484 1.18911

Lrrc59 leucine rich repeat containing 591.35E-08 5.60412 7.32E-09 6.4394 0.66491 1.03425 0.05012 1.18841

Wdr43 WD repeat domain 43 1.38E-06 2.13251 9.50E-08 2.91462 0.046834 -1.15015 0.020018 1.18833

ENY2 enhancer of yellow 2 homolog (Drosophila)1.37E-05 -2.20013 6.77E-05 -1.88303 0.855082 1.01599 0.075789 1.18709

Cbx7 chromobox homolog 7 2.38E-06 -2.74264 4.45E-06 -2.53184 0.314953 1.09568 0.079228 1.18691

Polr3b polymerase (RNA) III (DNA directed) polypeptide B0.0004411 1.48795 3.87E-06 2.16107 0.01833 -1.22751 0.041609 1.18319

Dusp7 dual specificity phosphatase 71.98E-05 2.65016 4.36E-06 3.30024 0.649294 -1.05297 0.163238 1.18266

RGD1560175similar to hypothetical protein KIAA20184.42E-05 -2.11841 0.000261 -1.78991 0.989126 -1.00132 0.113156 1.18197

Trpc2 transient receptor potential cation channel, subfamily C, member 21.63E-05 -2.46927 0.000226 -1.86694 0.287319 -1.11903 0.128662 1.18194

Nup205 nucleoporin 205 1.06E-06 1.95248 2.89E-07 2.20804 0.412642 1.04495 0.011154 1.18172

Scn11a sodium channel, voltage-gated, type XI, alpha0.648721 1.17839 0.179096 -1.66667 0.041407 2.32074 0.643318 1.18164

Unc13c unc-13 homolog C (C. elegans)3.99E-07 -5.82591 2.40E-07 -6.56331 0.041823 1.33058 0.196088 1.18109

Stard4 StAR-related lipid transfer (START) domain containing 40.0002019 1.6632 5.26E-06 2.32327 0.065971 -1.1833 0.069131 1.18049

Aurka aurora kinase A 3.79E-06 3.47476 4.10E-07 5.28656 0.052943 -1.2891 0.176947 1.18022

Mapk1ip1l Mitogen-activated protein kinase 1 interacting protein 1-like0.0015389 2.06545 0.001862 2.01942 0.25739 1.20702 0.314398 1.18012

Shisa4 shisa homolog 4 (Xenopus laevis)2.58E-05 1.98206 6.60E-06 2.27661 0.748799 1.02672 0.071859 1.17929

Vipr1 vasoactive intestinal peptide receptor 13.79E-05 -2.6756 0.042541 -1.33725 0.002338 -1.69673 0.208864 1.17922

Nupr1 nuclear protein, transcriptional regulator, 10.0274315 2.01106 0.010228 2.37986 0.989041 -1.00369 0.543468 1.17904

Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like0.0001571 2.59075 0.000173 2.55727 0.249612 1.19377 0.28326 1.17834

Dusp6 Dual specificity phosphatase 60.0465595 2.15611 0.027703 2.4043 0.870873 1.05637 0.629639 1.17797

Smo smoothened homolog (Drosophila)2.18E-05 3.30363 1.21E-05 3.64956 0.649528 1.06617 0.262407 1.17781

Trim14 tripartite motif-containing 147.87E-05 -3.2626 0.000936 -2.26563 0.245433 -1.22289 0.338377 1.17757

Fam98a family with sequence similarity 98, member A3.25E-06 1.84047 1.46E-07 2.48983 0.032081 -1.14927 0.016151 1.17711

Mn1 Meningioma 1 0.566021 -1.15259 0.11717 -1.51679 0.102333 1.549 0.511412 1.17707

Prim2 primase, DNA, polypeptide 26.08E-05 -2.33763 0.001768 -1.66641 0.152874 -1.19192 0.180934 1.17692

GRAMD1B GRAM domain containing 1B1.09E-05 -2.40684 0.000237 -1.77005 0.149903 -1.15573 0.111419 1.17653

Nrg1 neuregulin 1 0.0001161 2.56712 4.55E-06 4.34877 0.027182 -1.44035 0.264755 1.17612

Cenpw centromere protein W 0.0003264 1.98083 1.66E-05 2.83426 0.123287 -1.21713 0.193944 1.17558

Fbl fibrillarin 2.35E-06 1.8009 4.73E-07 2.0642 0.630407 1.02512 0.011685 1.175

Cenpt centromere protein T 0.0003056 2.30052 4.79E-05 2.96657 0.516376 -1.09798 0.276491 1.17445

Ncoa3 Nuclear receptor coactivator 32.93E-07 -3.01734 3.50E-07 -2.94225 0.093101 1.14504 0.053665 1.17427

Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domai1.85E-06 -3.12084 3.97E-06 -2.79822 0.598959 1.05225 0.123616 1.17357

of 148 Diabetes

Rad54l RAD54 like (S. cerevisiae)0.0081708 1.60369 0.000892 2.00241 0.656409 -1.06447 0.271949 1.173

Cadm1 cell adhesion molecule 11.05E-06 -5.18669 4.22E-06 -3.93962 0.378896 -1.1234 0.239806 1.17193

Itgb7 integrin, beta 7 0.46256 1.10025 0.177276 -1.20106 0.007732 1.54823 0.236771 1.1716

Mlf1ip myeloid leukemia factor 1 interacting protein5.63E-05 2.24271 4.98E-06 3.0747 0.170563 -1.17059 0.169346 1.17118

Iars isoleucyl-tRNA synthetase2.33E-08 2.49366 5.96E-09 2.96216 0.747671 -1.01427 0.00593 1.17116

Cenpq centromere protein Q 0.0008224 1.81217 0.000208 2.07986 0.865795 1.02015 0.205064 1.17084

Pcdha1 /// Pcdha10 /// Pcdha11 /// Pcdha12 /// Pcdha13 /// Pcdha2 /// Pcdha3 /// Pcdha4 /// Pcdha5 /// Pcdha6 /// Pcdha7 /// Pcdha8 /// Pcdha9 /// Pcdhac1 /// Pcdhac2protocadherin alpha 1 /// protocadherin alpha 10 /// protocadherin alpha 11 /// protoca0.335388 -1.18109 0.023144 -1.57608 0.025149 1.56236 0.35995 1.17081

Krtap13-2 keratin associated protein 13-20.0245383 -5.973 0.023346 -6.09896 0.78953 1.19543 0.813559 1.17074

Jmjd7 /// Pla2g4bjumonji domain containing 7 /// phospholipase A2, group IVB (cytosolic)9.01E-05 2.45006 1.57E-05 3.13091 0.496447 -1.09237 0.24148 1.16984

Zfp462 zinc finger protein 462 9.01E-08 -7.49886 2.20E-07 -6.03243 0.60047 -1.06266 0.197078 1.16979

Plk4 polo-like kinase 4 (Drosophila)0.0001545 1.95347 2.29E-05 2.39992 0.637088 -1.05031 0.156053 1.1697

Elmo2 engulfment and cell motility 20.0043026 -1.66237 8.28E-05 -2.56935 0.001781 1.80784 0.259152 1.16967

LOC100911253uncharacterized LOC1009112533.02E-05 -2.63578 0.000527 -1.89956 0.175549 -1.18661 0.211249 1.16935

Igfbp5 insulin-like growth factor binding protein 55.81E-08 -32.4589 1.50E-07 -21.8363 0.223754 -1.27135 0.415504 1.1692

RGD1307222similar to mKIAA0664 protein0.0001585 1.75564 1.92E-05 2.13026 0.666833 -1.03846 0.102568 1.16844

BMF Bcl2 modifying factor 9.44E-05 -2.59427 0.000335 -2.20867 0.969292 -1.00529 0.27488 1.16841

Snrpd1 small nuclear ribonucleoprotein D10.000439 1.96008 0.000183 2.15199 0.610811 1.06417 0.221832 1.16836

Abca2 ATP-binding cassette, sub-family A (ABC1), member 21.78E-05 -2.36496 9.57E-06 -2.54985 0.041442 1.25961 0.140686 1.16828

Farsb phenylalanyl-tRNA synthetase, beta subunit0.0005533 1.59027 2.38E-05 2.0738 0.224962 -1.11661 0.10145 1.16787

Snn stannin 1.01E-05 4.305 9.77E-06 4.33663 0.352009 1.15921 0.33 1.16772

Aldob aldolase B, fructose-bisphosphate7.23E-06 -2.57304 0.001002 -1.59395 0.008059 -1.38256 0.132491 1.16759

Slc29a2 solute carrier family 29 (nucleoside transporters), member 24.60E-05 2.37917 1.70E-05 2.70137 0.808616 1.0277 0.195064 1.16688

Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)0.0033312 1.67249 4.62E-05 2.69198 0.032656 -1.37954 0.251442 1.16674

Itgb4 integrin, beta 4 2.44E-05 1.96861 7.25E-06 2.22094 0.681375 1.03384 0.084411 1.16635

Hmox2 Heme oxygenase (decycling) 20.000284 -2.08611 0.000711 -1.89561 0.644341 1.05934 0.237665 1.1658

RGD1309534Similar to RIKEN cDNA 4931406C070.0002913 1.82368 3.54E-05 2.25246 0.571064 -1.05996 0.159458 1.16525

LOC679127 similar to Protein KIAA06900.0006758 1.83294 0.000198 2.07302 0.799964 1.03004 0.213584 1.16496

Ube2t ubiquitin-conjugating enzyme E2T (putative)0.0069507 1.60643 0.000529 2.0806 0.443423 -1.11189 0.279566 1.16484

Nup155 nucleoporin 155 2.31E-05 1.72439 3.15E-06 2.03773 0.823202 -1.01451 0.040271 1.16481

Csf3 colony stimulating factor 3 (granulocyte)0.0065862 4.73602 0.008023 4.46952 0.635784 1.23403 0.730573 1.16459

Wdr51a WD repeat domain 51A0.0008557 1.5384 2.38E-05 2.06495 0.126331 -1.15284 0.105423 1.16431

Crybb2 crystallin, beta B2 0.0912758 -3.79729 0.39982 -1.85585 0.440854 -1.7575 0.832381 1.16422

Chek2 CHK2 checkpoint homolog (S. pombe)0.0239827 1.42471 0.000321 2.14939 0.076305 -1.29591 0.267013 1.16416

Upp1 uridine phosphorylase 1 6.49E-06 -3.31294 1.70E-05 -2.86335 0.959572 1.00606 0.225127 1.16403

Fam195a family with sequence similarity 195, member A1.18E-07 -3.38238 1.15E-06 -2.47892 0.052265 -1.1722 0.061133 1.16402

of 148Diabetes

Cd3eap CD3e molecule, epsilon associated protein2.22E-05 1.71161 7.27E-07 2.32935 0.033934 -1.16921 0.038048 1.16396

Scnn1g sodium channel, nonvoltage-gated 1, gamma0.0264303 -1.46996 0.001852 -1.90941 0.019501 1.51171 0.316175 1.16379

Luzp5 Leucine zipper protein 5 5.19E-05 2.36578 1.09E-05 2.90216 0.638701 -1.05526 0.209198 1.16248

Rasd2 RASD family, member 2 3.10E-05 -3.84191 0.023614 -1.56422 0.001614 -2.11348 0.376437 1.16212

Sectm1b secreted and transmembrane 1B0.0010311 2.72203 3.82E-05 5.08786 0.044475 -1.60845 0.473306 1.16207

SCRN3 secernin 3 1.52E-05 -2.04808 0.000452 -1.55607 0.145271 -1.13325 0.089657 1.16143

Psip1 PC4 and SFRS1 interacting protein 17.57E-05 2.06966 3.89E-06 2.97293 0.062191 -1.23703 0.166523 1.1612

Pds5a PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)2.41E-07 1.7379 1.33E-08 2.22513 0.022577 -1.10265 0.002586 1.16116

Npas2 neuronal PAS domain protein 21.88E-05 3.83196 7.21E-06 4.61183 0.812309 -1.03739 0.349713 1.16014

RGD1306941similar to CG31122-PA 7.35E-05 1.60724 4.32E-06 2.00988 0.273069 -1.07797 0.048354 1.16007

Plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.0037597 -1.79857 0.000669 -2.18424 0.046284 1.40864 0.337643 1.15992

Reep6 receptor accessory protein 61.72E-06 -2.07624 8.95E-05 -1.534 0.031011 -1.16712 0.036687 1.15968

LOC304558 similar to TPR repeat-containing protein KIAA10437.24E-06 -2.85082 6.73E-06 -2.87987 0.161795 1.17124 0.187142 1.15943

Galntl4 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 41.80E-06 -5.79581 3.95E-06 -4.87527 0.863556 -1.02571 0.332484 1.15902

Hunk Hormonally upregulated Neu-associated kinase1.33E-06 -2.79324 7.37E-08 -4.44015 6.33E-05 1.84142 0.104722 1.15841

Uck2 uridine-cytidine kinase 20.0003056 2.04776 0.00011 2.29854 0.79771 1.03189 0.250002 1.15826


Nudc nuclear distribution gene C homolog (A. nidulans)3.10E-06 1.87382 3.50E-07 2.30345 0.307643 -1.06168 0.028451 1.15786

Sned1 sushi, nidogen and EGF-like domains 14.44E-05 -3.83418 0.016117 -1.66782 0.003562 -1.98587 0.410001 1.15763

Ehd2 EH-domain containing 2 1.38E-05 2.00246 1.75E-05 1.95939 0.053699 1.18249 0.084718 1.15706

LOC366669 similar to mKIAA1011 protein5.31E-07 -2.2491 5.11E-07 -2.25833 0.028787 1.16166 0.032226 1.15691

LOC302999 similar to tripartite motif protein 320.0038569 -2.18835 0.053959 -1.55279 0.340543 -1.21843 0.476729 1.15666

ACTN1 actinin, alpha 1 5.98E-05 7.33586 6.51E-05 7.16637 0.535093 1.18375 0.591936 1.15641

Asph aspartate-beta-hydroxylase0.0066174 -1.46588 0.000196 -1.97279 0.002987 1.55568 0.205474 1.15595

Srm spermidine synthase 1.74E-06 2.27754 4.58E-07 2.66184 0.864992 -1.01179 0.062736 1.15512

Pde4a Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)1.64E-07 -3.89678 7.42E-07 -3.06312 0.267983 -1.10154 0.114196 1.15489

C1ql3 Complement component 1, q subcomponent-like 30.0007647 -1.64692 0.544841 1.06181 0.002334 -1.51573 0.170136 1.15371

Fam120a family with sequence similarity 120A0.0190057 -1.62535 0.002393 -2.06233 0.050639 1.4637 0.41395 1.15357

Bmp6 bone morphogenetic protein 60.0004324 -1.87507 0.000127 -2.12419 0.040517 1.30626 0.229431 1.15307

Ska3 spindle and kinetochore associated complex subunit 37.93E-06 2.7201 1.64E-06 3.43101 0.391351 -1.09401 0.189068 1.15297

E2f5 E2F transcription factor 51.37E-06 2.35177 1.44E-07 3.14026 0.060491 -1.15814 0.067125 1.15295

Fn3k fructosamine 3 kinase 5.29E-06 -3.78605 2.91E-05 -2.8793 0.323013 -1.14069 0.28834 1.15274

Pkm2 pyruvate kinase, muscle 7.12E-06 2.40858 2.42E-06 2.75645 0.937687 1.00695 0.137173 1.15238

Accn2 amiloride-sensitive cation channel 2, neuronal0.0005225 -2.14927 0.000846 -2.03385 0.545656 1.09038 0.3316 1.15225

Sspn sarcospan 0.0004075 -2.10982 0.010128 -1.5391 0.214551 -1.18968 0.303337 1.15225

of 148 Diabetes

Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.0023217 3.00712 0.003151 2.84184 0.452892 1.21887 0.588477 1.15187

Itgb1bp1 integrin beta 1 binding protein 10.0381345 -1.45926 0.002635 -1.92429 0.02559 1.51751 0.383748 1.15079

Ahcy adenosylhomocysteinase5.00E-08 2.30488 3.96E-08 2.3633 0.027522 1.12214 0.011296 1.15059

Smad5 SMAD family member 5 9.30E-08 2.3666 1.97E-08 2.85588 0.347942 -1.04887 0.018998 1.15052

Gas5 growth arrest specific 5 7.00E-07 2.80641 3.16E-07 3.1372 0.708644 1.0292 0.095908 1.15051

LOC499339 hypothetical protein LOC4993391.02E-05 2.06186 4.93E-06 2.22097 0.401843 1.0679 0.095885 1.15031

Ube2k ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)7.70E-06 -2.16674 4.51E-05 -1.83654 0.74799 -1.02571 0.104006 1.15023

Mrto4 mRNA turnover 4 homolog (S. cerevisiae)3.45E-06 2.38129 9.99E-07 2.77428 0.865916 -1.01351 0.107835 1.1495

Ccdc75 coiled-coil domain containing 751.50E-06 1.65793 4.20E-08 2.22699 0.004569 -1.16951 0.008744 1.14855

LOC311134 hypothetical LOC3111348.17E-08 -4.00134 3.91E-08 -4.58559 0.006727 1.31611 0.105166 1.14842

Acot2 Acyl-CoA thioesterase 2 2.10E-06 -2.98211 3.60E-06 -2.76718 0.507206 1.06507 0.167505 1.14779

Isy1 ISY1 splicing factor homolog (S. cerevisiae)0.0003659 1.73776 7.48E-05 2.00588 0.949476 -1.00615 0.181348 1.14723

Rgs10 regulator of G-protein signaling 100.0177088 -1.81939 0.005609 -2.12664 0.182948 1.34074 0.514427 1.14704

OTUD7B OTU domain containing 7B0.663525 -1.02804 0.000836 -1.37384 0.000116 1.53265 0.055608 1.14688

Foxp2 Forkhead box P2 0.0024155 -3.90378 0.000326 -6.50322 0.072205 1.90944 0.673843 1.1462

Cpsf6 cleavage and polyadenylation specific factor 60.0014617 1.52278 5.05E-05 2.00451 0.156929 -1.1486 0.162874 1.14605

BTRC beta-transducin repeat containing8.82E-05 -2.0238 3.85E-05 -2.20705 0.051413 1.24924 0.199971 1.14552

Ccnf cyclin F 0.0004368 2.28702 4.49E-05 3.1566 0.230396 -1.20597 0.376883 1.1445

Mid1ip1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))2.35E-05 -2.10207 0.000716 -1.5731 0.106091 -1.16793 0.152905 1.14412

Pou6f1 POU class 6 homeobox 14.19E-05 -2.52772 1.61E-05 -2.879 0.051677 1.30132 0.281038 1.14254

Mocs2 molybdenum cofactor synthesis 20.0031831 -2.12484 0.013574 -1.77091 0.794065 -1.05017 0.483455 1.14254

Ubl4 ubiquitin-like 4 5.33E-07 -2.28561 1.39E-06 -2.07436 0.55222 1.0363 0.049838 1.14184

Txnip thioredoxin interacting protein0.0066294 -3.28884 0.00218 -4.27402 0.263143 1.48308 0.697201 1.14123

Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein)0.0055888 1.66095 0.000836 2.01563 0.660884 -1.06349 0.357362 1.14109

Cldn8 claudin 8 3.26E-05 -3.97185 7.55E-05 -3.41004 0.902724 -1.0211 0.449509 1.14068

Slc38a1 solute carrier family 38, member 10.0022191 2.20962 0.002183 2.21447 0.492911 1.13746 0.485805 1.13996

Cit Citron 3.39E-05 2.01864 6.35E-06 2.41456 0.580524 -1.05004 0.163029 1.13913

Galm galactose mutarotase (aldose 1-epimerase)8.06E-06 -4.88598 9.58E-05 -3.09114 0.071124 -1.38773 0.432641 1.13901

LOC687022 similar to SEC22 vesicle trafficking protein-like 35.55E-08 -5.39555 6.27E-08 -5.25665 0.271196 1.10915 0.177301 1.13846

Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide1.95E-08 2.86403 1.81E-08 2.89302 0.037151 1.12704 0.026798 1.13845

Crebl2 cAMP responsive element binding protein-like 20.0418893 -1.85524 0.023748 -2.03675 0.409496 1.24896 0.627253 1.13765

NFIB nuclear factor I/B 1.91E-05 1.91288 4.00E-06 2.22524 0.763815 -1.02275 0.113079 1.13742

Ipo7 importin 7 2.39E-05 1.97656 7.26E-06 2.22595 0.906664 1.00953 0.140182 1.1369

Ophn1 oligophrenin 1 0.526659 -1.07127 0.009765 -1.42003 0.004292 1.50664 0.253272 1.13661

Cdca2 cell division cycle associated 20.0140549 1.58306 0.000365 2.37559 0.09513 -1.32028 0.408642 1.1366

of 148Diabetes

Fads1 fatty acid desaturase 1 0.720779 1.12116 0.014662 2.60509 0.049191 -2.04505 0.690153 1.13619


Gmnn geminin 1.12E-05 2.58183 1.45E-05 2.50066 0.145676 1.17203 0.233938 1.13519

Eef2k eukaryotic elongation factor-2 kinase4.64E-06 -4.08851 3.09E-06 -4.41824 0.154812 1.22647 0.358521 1.13493

TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)0.189678 -1.32001 0.017304 -1.78499 0.057988 1.53464 0.531961 1.13488

C1r complement component 1, r subcomponent0.0003331 4.7663 0.000493 4.35616 0.431736 1.24163 0.641566 1.13479

Aars alanyl-tRNA synthetase 2.14E-05 2.40859 2.79E-05 2.33509 0.153759 1.16997 0.241621 1.13427

Cep70 centrosomal protein 70kDa6.96E-05 -2.14696 0.001183 -1.64911 0.212334 -1.14817 0.252746 1.13388

Heatr1 HEAT repeat containing 11.91E-05 1.97632 3.62E-06 2.34245 0.572544 -1.04573 0.13795 1.13343

Bin2a beta-galactosidase-like protein3.64E-05 -2.09758 0.000452 -1.67375 0.296672 -1.10605 0.203843 1.13306

Nhp2 NHP2 ribonucleoprotein homolog (yeast)3.17E-05 2.08551 5.36E-06 2.54661 0.418925 -1.07779 0.19336 1.13297

Clpb ClpB caseinolytic peptidase B homolog (E. coli)6.65E-07 -3.09443 5.96E-07 -3.14467 0.120321 1.15083 0.162326 1.13244

Anpep alanyl (membrane) aminopeptidase7.00E-07 2.33265 1.25E-06 2.19367 0.015973 1.204 0.076076 1.13227

Snx12 sorting nexin 12 0.000216 -2.00908 0.002689 -1.598 0.365449 -1.1108 0.290977 1.13183

Snx12 sorting nexin 12 0.000216 -2.00908 0.002689 -1.598 0.365449 -1.1108 0.290977 1.13183

Plp1 proteolipid protein 1 1.91E-07 -2.45401 5.22E-06 -1.79228 0.008284 -1.20981 0.05344 1.13176

Map3k1 mitogen activated protein kinase kinase kinase 11.32E-05 -2.00927 1.58E-05 -1.97556 0.187147 1.11272 0.133262 1.13171

LOC679462 similar to Tetraspanin-15 (Tspan-15) (Transmembrane 4 superfamily member 15) (Tetraspan2.29E-06 -3.51459 4.50E-06 -3.15692 0.882014 1.01632 0.275958 1.13147

F2rl2 coagulation factor II (thrombin) receptor-like 23.38E-06 4.63831 6.43E-06 4.09108 0.103901 1.28278 0.389542 1.13144

LOC100360982avian reticuloendotheliosis viral (v-rel) oncogene related B1.11E-05 2.44672 8.31E-06 2.53396 0.371037 1.09184 0.221586 1.13077

Lynx1 Ly6/neurotoxin 1 2.57E-06 -3.46029 4.49E-06 -3.16815 0.752148 1.03523 0.279683 1.1307

Nat13 N-acetyltransferase 13 4.14E-05 1.90273 9.12E-06 2.20434 0.767379 -1.02473 0.162709 1.13056

Ces2l carboxylesterase 2-like 1.62E-06 -2.29144 2.32E-05 -1.78832 0.096413 -1.1336 0.103066 1.13033

Hs3st6 heparan sulfate (glucosamine) 3-O-sulfotransferase 66.60E-06 -2.42739 5.01E-06 -2.50919 0.108045 1.16781 0.192667 1.12974

Zfp593 zinc finger protein 593 1.03E-07 -5.96238 2.38E-07 -4.9741 0.569945 -1.06135 0.260559 1.1294

Mboat2 membrane bound O-acyltransferase domain containing 20.0036827 -2.57084 0.000415 -3.8476 0.054485 1.69006 0.616228 1.12924

Gatsl3 GATS protein-like 3 2.34E-05 -2.41749 7.36E-05 -2.12292 0.935507 -1.00849 0.264441 1.12917

Igf2r insulin-like growth factor 2 receptor0.0358193 1.54245 0.002928 2.06528 0.350011 -1.18614 0.501018 1.12884

Rb1 retinoblastoma 1 2.37E-05 -2.21427 7.93E-06 -2.51375 0.02646 1.28143 0.221424 1.12877

Elmo2 engulfment and cell motility 24.36E-07 -3.35871 1.62E-07 -3.95934 0.008353 1.33021 0.179147 1.12842

Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 11.91E-05 -2.48575 0.000241 -1.89066 0.170821 -1.16522 0.268879 1.12833

RGD1305311Similar to hypothetical protein FLJ225270.0001733 -2.70282 0.001165 -2.10348 0.412433 -1.13961 0.450128 1.12751

Eprs glutamyl-prolyl-tRNA synthetase4.22E-05 1.67483 2.91E-06 2.09458 0.144233 -1.10941 0.098763 1.12729

Mustn1 musculoskeletal, embryonic nuclear protein 12.78E-06 -2.34845 1.03E-05 -2.04967 0.830498 -1.01641 0.142312 1.12727

Rapgefl1 Rap guanine nucleotide exchange factor (GEF)-like 11.05E-06 -3.16378 2.28E-06 -2.83032 0.930187 1.00794 0.209595 1.12669

of 148 Diabetes

Degs1 degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)6.64E-06 2.2534 1.01E-06 2.8318 0.199257 -1.1163 0.170308 1.12576

LOC500688 Similar to a disintegrin and metalloprotease domain 47.12E-08 -2.40696 1.71E-07 -2.19343 0.607018 1.02556 0.036644 1.1254

Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 20.0016577 3.02593 0.001475 3.09191 0.696131 1.10136 0.633623 1.12538

Lin7a lin-7 homolog a (C. elegans)0.0172789 -1.42061 0.172252 1.19231 0.008264 -1.50513 0.34363 1.12536

Dynll2 dynein light chain LC8-type 21.68E-06 -2.41577 4.72E-06 -2.15979 0.934336 1.00607 0.135923 1.12531

Hsp90b1 heat shock protein 90kDa beta (Grp94), member 11.10E-06 2.20671 5.70E-07 2.368 0.454556 1.04866 0.086605 1.1253

Adamtsl1 ADAMTS-like 1 2.52E-06 8.43517 1.88E-06 9.16586 0.853584 1.0352 0.534901 1.12487

Bcas3 breast carcinoma amplified sequence 30.0005197 -2.01993 0.009318 -1.53487 0.246725 -1.17039 0.378836 1.12443

Lgi1 /// LOC100361792leucine-rich, glioma inactivated 1 /// leucine-rich glioma-inactivated protein 1-like0.8243 -1.029 0.001341 -1.82062 0.000563 1.98856 0.375919 1.12392

UGGT1 UDP-glucose glycoprotein glucosyltransferase 17.07E-08 2.0526 4.13E-08 2.16001 0.126331 1.06803 0.016341 1.12392

Hddc3 HD domain containing 3 4.61E-05 -2.256 0.000266 -1.88312 0.550141 -1.06601 0.287583 1.12383

Tmem38a transmembrane protein 38a6.76E-06 -2.29712 1.18E-06 -2.84959 0.003361 1.39385 0.186533 1.12361

Crygs crystallin, gamma S 0.0464616 -2.41962 0.337674 -1.46661 0.336144 -1.4685 0.764477 1.12346

Pabpc4 poly(A) binding protein, cytoplasmic 44.66E-09 3.26574 2.08E-09 3.70782 0.815704 -1.01089 0.032455 1.12314

ARHGAP29 Rho GTPase activating protein 290.0151884 2.2045 0.031221 1.95437 0.384114 1.26687 0.663291 1.12313

Slc25a29 solute carrier family 25, member 291.55E-05 -2.05385 6.18E-05 -1.81258 0.906238 -1.00953 0.177166 1.12241

Myo5c myosin VC 6.34E-07 -3.25816 3.09E-06 -2.61281 0.243078 -1.11164 0.20845 1.12176

SEC14L3 SEC14-like 3 (S. cerevisiae)1.72E-05 -3.74132 5.05E-05 -3.11856 0.654885 -1.06966 0.45185 1.12157

LOC100361585rCG31991-like 3.60E-05 -1.87537 1.35E-05 -2.05191 0.028184 1.22704 0.172425 1.12148

Nars asparaginyl-tRNA synthetase2.64E-08 2.42585 1.93E-08 2.51502 0.09887 1.08143 0.025933 1.12117

Sipa1 signal-induced proliferation-associated 18.63E-05 2.33981 6.23E-05 2.43492 0.548886 1.0759 0.362059 1.11963

RGD1310429similar to Protein Njmu-R10.0001905 -2.27088 0.000512 -2.02907 0.997196 -1.00046 0.400958 1.11866

Fam132a family with sequence similarity 132, member A1.12E-05 2.29051 1.39E-05 2.23661 0.15279 1.14559 0.228804 1.11863

Gldc glycine dehydrogenase (decarboxylating)1.49E-05 -3.50411 3.71E-05 -3.02405 0.79518 -1.03697 0.435453 1.11744

Kctd15 potassium channel tetramerisation domain containing 155.27E-05 -2.01692 0.000343 -1.70816 0.556064 -1.05687 0.253226 1.11722

SPRED2 sprouty-related, EVH1 domain containing 21.50E-05 -2.02508 0.000107 -1.71109 0.463397 -1.0604 0.187274 1.11609

LOC100362483H2-GS14-2 antigen 0.579497 -1.40877 0.274979 -2.00459 0.459182 1.58642 0.859159 1.11489

Cdh3 cadherin 3 3.16E-08 3.70907 5.12E-08 3.43031 0.018706 1.20507 0.125886 1.1145

Thop1 thimet oligopeptidase 1 9.34E-06 2.83175 2.45E-06 3.46666 0.396092 -1.09915 0.336706 1.11377

Tfrc transferrin receptor 3.80E-05 3.76571 3.68E-05 3.78765 0.552721 1.10598 0.530615 1.11242

Cpb1 carboxypeptidase B1 (tissue)1.14E-08 -3.42758 3.54E-07 -2.21424 0.000231 -1.39192 0.077232 1.11211

Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 23.48E-06 1.98309 5.90E-07 2.37061 0.26769 -1.07512 0.119231 1.11189


Fam171a1 /// LOC684862family with sequence similarity 171, member A1 /// hypothetical protein LOC6848622.37E-07 8.15793 2.19E-06 4.81714 0.00133 1.8828 0.443408 1.11177

Tmem218 transmembrane protein 2185.50E-06 -2.51086 1.68E-05 -2.20849 0.803137 -1.02264 0.257515 1.11174

of 148Diabetes

Cinp cyclin-dependent kinase 2-interacting protein3.82E-05 2.03332 5.75E-06 2.50252 0.27498 -1.10743 0.259903 1.11136

LOC100361122SRY-box containing gene 95.48E-05 2.83574 0.000109 2.57415 0.170786 1.22429 0.455019 1.11135

Cdca4 cell division cycle associated 41.82E-06 1.72699 2.14E-07 2.05641 0.160079 -1.07146 0.045348 1.11134

Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 31.66E-06 -3.91401 1.63E-05 -2.73693 0.050885 -1.28702 0.365871 1.11115

Scd1 stearoyl-Coenzyme A desaturase 10.0139218 2.24806 0.006339 2.57963 0.903242 -1.03296 0.694774 1.11088

Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 20.0006 -2.27179 0.002355 -1.93033 0.709511 -1.05971 0.504855 1.11058

Ifitm2 interferon induced transmembrane protein 20.00023 3.21331 0.000837 2.60959 0.129438 1.36702 0.587474 1.11018

Wnt6 wingless-type MMTV integration site family, member 62.80E-07 -2.87373 9.38E-07 -2.46632 0.485732 -1.05059 0.16381 1.10908

RGD1565800Similar to hypothetical protein FLJ206743.73E-08 -2.26962 4.50E-08 -2.22609 0.07339 1.08704 0.034835 1.1083

Txndc17 thioredoxin domain containing 176.20E-06 2.12971 2.25E-06 2.37341 0.935894 -1.00604 0.195802 1.10774

Alox12e arachidonate 12-lipoxygenase, epidermal2.33E-06 -3.82385 6.02E-06 -3.26465 0.633299 -1.05764 0.392826 1.10745

Hnrnpa2b1 Heterogeneous nuclear ribonucleoprotein A2/B11.88E-05 -2.40772 5.99E-05 -2.11513 0.781423 -1.02848 0.330031 1.10681

Lpl lipoprotein lipase 2.43E-06 11.098 1.54E-06 12.8802 0.82053 -1.04896 0.633186 1.10642

Crygc crystallin, gamma C 0.0840895 -1.91032 0.058024 -2.066 0.600217 1.19613 0.766739 1.10599


Rpia ribose 5-phosphate isomerase A0.0733898 -1.63984 0.006789 -2.38479 0.083339 1.60787 0.686869 1.10561

Bard1 BRCA1 associated RING domain 10.0003614 1.79673 5.77E-05 2.14714 0.454937 -1.0811 0.34253 1.10538

Golsyn Golgi-localized protein 0.0006355 -5.42852 0.001232 -4.58719 0.831556 -1.07108 0.757785 1.10487

Tek TEK tyrosine kinase, endothelial0.0434224 -1.97851 0.038212 -2.02522 0.67741 1.13077 0.735604 1.10469

Unc5c unc-5 homolog C (C. elegans)0.00225 -2.05195 0.00092 -2.29857 0.228317 1.2368 0.560107 1.10411

Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.0006559 1.6629 6.18E-06 2.67735 0.003931 -1.45926 0.328025 1.10333

Ankrd42 ankyrin repeat domain 428.10E-05 -2.04343 0.000561 -1.71192 0.442502 -1.08188 0.342436 1.1033

Hspd1 heat shock protein 1 (chaperonin)1.42E-06 1.84297 3.90E-07 2.06054 0.78867 -1.01347 0.076364 1.10319

Phospho1 phosphatase, orphan 1 6.31E-07 -8.65067 2.63E-06 -5.99481 0.117414 -1.30861 0.541413 1.10271

Ptpn14 Protein tyrosine phosphatase, non-receptor type 148.86E-05 -3.07341 0.000144 -2.85137 0.888531 1.02268 0.547191 1.10232

Dcaf4 DDB1 and CUL4 associated factor 42.18E-05 -2.27845 0.000129 -1.90164 0.398331 -1.08707 0.328857 1.10218

Taf1d TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa0.0005536 2.09315 0.000621 2.0662 0.433775 1.11635 0.487912 1.10198

LOC679342 hypothetical protein LOC6793422.75E-06 3.15345 3.87E-07 4.40542 0.043214 -1.26784 0.355324 1.10189

Col14a1 collagen, type XIV, alpha 12.38E-07 -11.4106 1.80E-07 -12.4672 0.259521 1.20332 0.544486 1.10133


Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 565.79E-06 2.03632 5.18E-07 2.65266 0.037444 -1.18333 0.192807 1.10085

Sorcs1 sortilin-related VPS10 domain containing receptor 10.0082222 -2.36044 0.009563 -2.30162 0.781749 1.0731 0.707411 1.10053

Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 391.83E-06 2.32949 2.70E-07 2.95619 0.072692 -1.15324 0.20304 1.10041

Fam178b family with sequence similarity 178, member B6.02E-06 -2.17615 1.66E-05 -1.97052 0.962287 -1.00363 0.23385 1.10036

Sigmar1 sigma non-opioid intracellular receptor 10.0005138 2.09316 0.000123 2.49176 0.565623 -1.08234 0.491507 1.09987

of 148 Diabetes

Mre11a MRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.0002042 1.5409 2.68E-06 2.19115 0.00508 -1.29337 0.196697 1.09945

Thsd7a thrombospondin, type I, domain containing 7A0.0002415 -2.26881 0.000349 -2.17179 0.709156 1.05184 0.49154 1.09883

Taf9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor9.53E-06 2.37376 7.20E-06 2.45373 0.507817 1.06276 0.315612 1.09856

Pstpip1 proline-serine-threonine phosphatase-interacting protein 10.0001635 2.24785 0.000155 2.2627 0.49504 1.0912 0.464138 1.0984

LOC100911253uncharacterized LOC1009112532.91E-05 -2.21189 0.001736 -1.54074 0.021126 -1.30779 0.349267 1.09774

Emb embigin homolog (mouse)0.0002787 1.9491 0.000167 2.05328 0.716296 1.04182 0.417322 1.0975

Fgfbp1 fibroblast growth factor binding protein 12.23E-07 3.58149 3.13E-08 5.15183 0.009094 -1.31141 0.277065 1.09688

Hip1 huntingtin interacting protein 15.22E-05 3.18767 9.72E-05 2.89229 0.237789 1.2087 0.551659 1.0967

USP15 ubiquitin specific peptidase 156.69E-05 -3.27374 0.001403 -2.11919 0.060837 -1.40923 0.575432 1.09621

LOC100365845rCG26214-like 2.46E-08 -2.23592 6.00E-08 -2.05078 0.889782 1.00541 0.040946 1.09618

Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)8.23E-10 9.07962 6.63E-10 9.64754 0.664166 1.03082 0.213489 1.0953

Casc5 cancer susceptibility candidate 50.0044112 1.74406 0.000465 2.23804 0.295989 -1.17186 0.540033 1.09504

Tox3 TOX high mobility group box family member 30.0014429 -2.40157 0.004103 -2.08043 0.781774 -1.05425 0.635955 1.09496

Lrpprc leucine-rich PPR-motif containing1.51E-07 -2.54813 3.00E-07 -2.3548 0.842283 1.01143 0.141112 1.09446

Cyfip2 cytoplasmic FMR1 interacting protein 21.96E-08 -6.33995 8.71E-09 -7.74165 0.008809 1.3358 0.317061 1.09394

LOC100911177uncharacterized LOC1009111770.0001108 2.21887 4.64E-05 2.46187 0.902131 -1.01452 0.453397 1.09364

Adh1 alcohol dehydrogenase 1 (class I)5.29E-05 -6.75372 0.000613 -3.80058 0.083106 -1.62496 0.724743 1.09358

Smurf1 SMAD specific E3 ubiquitin protein ligase 10.0045989 1.72392 0.000936 2.03992 0.588367 -1.08209 0.540717 1.09353

Rnf167 ring finger protein 167 3.78E-09 -2.14974 2.32E-08 -1.8375 0.043681 -1.07009 0.013591 1.0933

Ptgfrn prostaglandin F2 receptor negative regulator4.32E-05 1.96244 3.10E-05 2.02574 0.518937 1.05841 0.323604 1.09255

Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein6.22E-07 2.26712 9.30E-08 2.84345 0.04431 -1.14839 0.16738 1.09215

Chd6 chromodomain helicase DNA binding protein 60.0073957 -1.64055 0.000468 -2.20118 0.025295 1.46449 0.546465 1.09149

Mboat2 membrane bound O-acyltransferase domain containing 20.0043572 -2.51121 0.000552 -3.65586 0.083503 1.58896 0.71846 1.09146

Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 15.05E-06 3.60513 2.21E-06 4.18098 0.625715 -1.06257 0.485531 1.09144

Acsf2 acyl-CoA synthetase family member 26.86E-05 2.00473 0.000133 1.88372 0.145331 1.16114 0.374211 1.09106

Enah enabled homolog (Drosophila)5.37E-09 8.70628 7.71E-09 7.90294 0.059661 1.20142 0.330516 1.09056

MGC112715 platelet receptor Gi24 0.0020223 2.09442 0.000449 2.5596 0.508033 -1.12076 0.613143 1.09042

Serpinb10 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 102.38E-11 305.695 2.32E-11 311.583 0.564063 1.0697 0.46231 1.0903

Fam5b family with sequence similarity 5, member B0.0001033 -3.84247 0.039635 -1.59399 0.003084 -2.21159 0.662113 1.08999

Rfc1 replication factor C (activator 1) 11.84E-05 -2.11321 1.74E-05 -2.12524 0.301299 1.09614 0.330212 1.08994

Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a6.90E-08 -2.55094 4.81E-08 -2.66605 0.032326 1.13823 0.126716 1.08909

Rps6ka6 Ribosomal protein S6 kinase polypeptide 67.50E-07 7.2156 3.15E-07 9.11793 0.330636 -1.16035 0.56903 1.08902

Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 10.0028626 -4.75273 0.001959 -5.27469 0.621145 1.20834 0.823123 1.08877

Cmbl carboxymethylenebutenolidase homolog (Pseudomonas)1.33E-09 -7.1532 2.24E-07 -2.78953 9.05E-07 -2.35559 0.219936 1.0886

Cenpi centromere protein I 0.0011219 2.84115 0.000719 3.06614 0.969929 1.00824 0.699545 1.08808

of 148Diabetes

Slc39a2 solute carrier family 39 (zinc transporter), member 20.001131 2.99787 0.000381 3.67039 0.609528 -1.1253 0.714017 1.08801

Thg1l tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)6.96E-06 2.0519 2.99E-06 2.23409 0.990884 -1.00083 0.263131 1.08789

Plekha6 Pleckstrin homology domain containing, family A member 64.98E-09 -3.32414 9.05E-09 -3.04598 0.930903 -1.00413 0.107921 1.08684

SNRPA1 small nuclear ribonucleoprotein polypeptide A'9.62E-07 1.89658 2.11E-07 2.17894 0.276329 -1.05773 0.123609 1.08618

Trim44 Tripartite motif-containing 440.0077301 -1.61049 0.925867 1.01305 0.016621 -1.50282 0.559649 1.08563

Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.0089692 1.54329 0.000367 2.10672 0.106817 -1.25844 0.538338 1.08474

Oxr1 oxidation resistance 1 4.81E-07 -4.19852 9.32E-07 -3.73213 0.712299 -1.03833 0.439157 1.08343

Capn3 calpain 3 9.63E-06 -2.18775 8.20E-06 -2.2254 0.258382 1.10173 0.345489 1.08309

Sirt3 sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)5.09E-06 -2.10614 7.63E-06 -2.02516 0.58061 1.04087 0.287531 1.08249

Cenpv centromere protein V 1.48E-06 6.69513 8.29E-07 7.76716 0.656283 -1.07223 0.615776 1.08197

Vezf1 vascular endothelial zinc finger 12.74E-06 -3.15737 9.62E-06 -2.64617 0.351243 -1.10292 0.44959 1.08185

Gpnmb glycoprotein (transmembrane) nmb0.0001964 -2.87293 0.000124 -3.08856 0.383198 1.1627 0.644309 1.08152

Btbd1 BTB (POZ) domain containing 11.73E-07 -2.45944 1.52E-07 -2.49696 0.122921 1.0978 0.186568 1.0813

Lppr5 lipid phosphate phosphatase-related protein type 50.001379 -2.04981 0.01514 -1.58676 0.269307 -1.1948 0.616712 1.0812

Tmem8a transmembrane protein 8A5.37E-05 3.66918 2.83E-05 4.13881 0.805814 -1.04342 0.653632 1.08106

Asf1a ASF1 anti-silencing function 1 homolog A (S. cerevisiae)8.27E-07 -2.90614 2.18E-06 -2.55968 0.546257 -1.0507 0.352561 1.08056

Unc5c unc-5 homolog C (C. elegans)0.0005646 -2.4405 0.001258 -2.19518 0.864036 -1.02903 0.645548 1.08039

Il6r interleukin 6 receptor 0.0001721 -2.07634 0.001842 -1.65918 0.220551 -1.15887 0.508213 1.07987

Galr2 galanin receptor 2 0.000299 -2.14157 0.00036 -2.09767 0.666662 1.05769 0.557393 1.07983

Cyp20a1 cytochrome P450, family 20, subfamily a, polypeptide 15.84E-07 2.83731 2.33E-07 3.2337 0.477137 -1.05623 0.330095 1.07903

Klf10 Kruppel-like factor 10 0.0042838 2.06088 0.004316 2.05886 0.686677 1.07977 0.690439 1.07871

Igfbp5 insulin-like growth factor binding protein 57.46E-06 -3.61487 5.35E-05 -2.67038 0.109766 -1.25505 0.565702 1.0786

Nat1 N-acetyltransferase 1 (arylamine N-acetyltransferase)0.0002013 -2.11085 0.000473 -1.93018 0.906533 -1.01417 0.534114 1.07833

Dars2 aspartyl-tRNA synthetase 2 (mitochondrial)1.57E-06 -2.82348 2.59E-06 -2.64247 0.91628 1.00905 0.39118 1.07817

Kbtbd4 Kelch repeat and BTB (POZ) domain containing 45.58E-08 -2.71778 2.32E-07 -2.30039 0.116017 -1.09603 0.187208 1.07793

Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)0.0004632 -2.89369 0.000275 -3.15522 0.412807 1.17528 0.69887 1.07787

Atg4c ATG4 autophagy related 4 homolog C (S. cerevisiae)1.71E-06 -4.84691 1.47E-06 -4.99636 0.433387 1.11103 0.573463 1.07779

Rab11fip4 RAB11 family interacting protein 4 (class II)0.0001857 -2.12657 0.001606 -1.71755 0.264396 -1.14919 0.537911 1.07741

Tenc1 tensin like C1 domain containing phosphatase (tensin 2)2.65E-05 -2.05469 6.23E-06 -2.39997 0.025621 1.25838 0.401122 1.07733

Prrt1 proline-rich transmembrane protein 10.0001621 -2.59404 0.000434 -2.27914 0.711002 -1.05665 0.618557 1.07715

Ptpn14 Protein tyrosine phosphatase, non-receptor type 148.12E-05 -3.02277 0.000199 -2.64522 0.705083 -1.06096 0.635809 1.07707

Bxdc2 brix domain containing 23.89E-05 1.78882 7.07E-06 2.08169 0.309282 -1.08077 0.331537 1.07676

Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate c0.0001346 5.27168 0.000677 3.6923 0.115887 1.5366 0.770671 1.07624

Tpm1 tropomyosin 1, alpha 7.95E-05 3.78323 0.000292 3.01091 0.134112 1.35193 0.696367 1.07594

Igf2r insulin-like growth factor 2 receptor0.0004849 1.67212 3.84E-05 2.0998 0.127709 -1.1674 0.446219 1.0757

of 148 Diabetes

Anxa1 annexin A1 0.0007475 2.77396 0.030528 1.66015 0.016235 1.79722 0.71596 1.0756

Ard1a ARD1 homolog A, N-acetyltransferase (S. cerevisiae)9.45E-06 2.33084 7.73E-06 2.38549 0.57939 1.05084 0.421307 1.07548

Psca prostate stem cell antigen0.0001728 -2.48545 0.000256 -2.36229 0.87927 1.02193 0.614366 1.07521

Gpr114 G protein-coupled receptor 1140.0005043 -2.77956 0.026217 -1.6418 0.037328 -1.57515 0.70251 1.07481

Ngfr nerve growth factor receptor (TNFR superfamily, member 16)6.55E-08 -5.82272 1.75E-07 -4.72707 0.181772 -1.14666 0.466078 1.07424

LOC100362120rCG47836-like 0.0001084 -1.76729 1.43E-05 -2.12587 0.013236 1.29213 0.402258 1.07417

Cd97 CD97 molecule 6.03E-05 2.65135 2.51E-05 3.0076 0.677764 -1.0565 0.592275 1.0737

Hnrnpa1 heterogeneous nuclear ribonucleoprotein A12.98E-09 2.67733 4.31E-10 3.51278 0.000461 -1.22275 0.081325 1.07303

Hspe1 heat shock protein 1 (chaperonin 10)2.40E-07 1.8929 1.12E-07 2.02095 0.907391 1.00482 0.117279 1.07279

Rab40b Rab40b, member RAS oncogene family7.83E-05 -2.32487 0.00141 -1.72604 0.081814 -1.25573 0.557101 1.07264

Rhebl1 Ras homolog enriched in brain like 15.52E-06 -1.85468 1.55E-06 -2.07516 0.014216 1.19962 0.266403 1.07217

Cdk2ap1 CDK2-associated protein 17.14E-09 2.48821 2.79E-09 2.7912 0.247316 -1.04667 0.094521 1.07175

Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1003.63E-06 2.94563 3.94E-06 2.91224 0.429042 1.0837 0.495055 1.07141

Pigp Phosphatidylinositol glycan anchor biosynthesis, class P0.0456895 -1.71195 0.008898 -2.18396 0.207328 1.36621 0.770848 1.07094

Adfp adipose differentiation related protein4.47E-06 7.59338 2.79E-06 8.6543 0.746415 -1.06429 0.722517 1.07087

Tril TLR4 interactor with leucine-rich repeats7.17E-07 -27.7915 1.98E-06 -18.3893 0.189122 -1.41158 0.783494 1.07063

Eno1 enolase 1, (alpha) 2.18E-08 2.12519 1.72E-08 2.17516 0.233473 1.04589 0.086139 1.07049

Plk1s1 polo-like kinase 1 substrate 16.21E-05 -3.03518 0.0001 -2.82332 0.976077 -1.00452 0.654057 1.0702

Apc2 adenomatosis polyposis coli 20.0001483 -2.19557 0.000926 -1.81573 0.322303 -1.13122 0.584134 1.06893

Rnf4 ring finger protein 4 0.0007191 1.7603 9.93E-05 2.13602 0.267749 -1.13522 0.548908 1.0689

Lrp1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)0.000353 -1.72463 4.31E-05 -2.09112 0.022694 1.29565 0.491672 1.06857

Cars cysteinyl-tRNA synthetase2.60E-05 2.76815 6.94E-05 2.43195 0.137774 1.21582 0.593204 1.06815

Nkrf NFKB repressing factor0.0001149 1.77927 1.75E-05 2.11492 0.231248 -1.11288 0.447979 1.06808

Grwd1 glutamate-rich WD repeat containing 16.32E-05 1.70781 8.89E-06 2.01397 0.19605 -1.10448 0.379586 1.06771

Syngr1 synaptogyrin 1 2.41E-05 -3.61906 2.50E-05 -3.59643 0.700024 1.06095 0.670354 1.06762

LOC680200 similar to zinc finger protein 4550.0004317 -2.02007 0.004243 -1.62148 0.242668 -1.16697 0.607727 1.06757

Cryba2 crystallin, beta A2 0.050854 -4.17362 0.439071 -1.66011 0.206033 -2.35549 0.919223 1.06732

Bmyc brain expressed myelocytomatosis oncogene3.23E-05 -2.94722 0.000117 -2.464 0.404983 -1.12068 0.62881 1.0673

Tmem14c transmembrane protein 14C5.94E-05 1.99301 1.72E-05 2.26569 0.502366 -1.06524 0.490462 1.06719

Galm galactose mutarotase (aldose 1-epimerase)2.05E-06 -4.40997 1.25E-05 -3.2116 0.074253 -1.28688 0.611897 1.06703

LOC298018 hypothetical LOC2980180.0006684 1.8571 0.000132 2.20034 0.389783 -1.11047 0.58924 1.06696

Pycard PYD and CARD domain containing1.41E-05 -2.45138 1.12E-05 -2.52209 0.36103 1.09742 0.520252 1.06666

Fam169a family with sequence similarity 169, member A0.0002313 -4.06329 0.000623 -3.34456 0.573222 -1.13948 0.780472 1.06619

Pmm1 phosphomannomutase 11.76E-06 -2.0455 1.26E-06 -2.11246 0.137747 1.10058 0.305473 1.06569

Mtap Methylthioadenosine phosphorylase9.87E-06 2.30548 3.17E-06 2.64164 0.415184 -1.076 0.4819 1.06488

of 148Diabetes

Ard1a ARD1 homolog A, N-acetyltransferase (S. cerevisiae)1.54E-06 2.37506 8.14E-07 2.55938 0.867464 -1.01197 0.38916 1.06486

protein kinase-like protein SgK196Sgk196 3.23E-07 -2.13867 2.17E-07 -2.22649 0.071357 1.10843 0.241267 1.06471

Mmp9 matrix metallopeptidase 95.14E-05 31.7237 4.70E-05 33.1467 0.968287 1.0183 0.891914 1.06398

Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 17.03E-05 -2.67542 8.08E-05 -2.62468 0.754602 1.04345 0.651469 1.06363

Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B0.0049574 3.034 0.006384 2.88289 0.707167 1.11916 0.836902 1.06342

Cars cysteinyl-tRNA synthetase3.01E-05 2.51794 8.42E-05 2.22501 0.129885 1.20327 0.59097 1.06328

Ydjc YdjC homolog (bacterial)0.0007814 2.00238 0.000304 2.23022 0.734613 -1.0476 0.65603 1.06318

Lmo4 LIM domain only 4 1.87E-06 -2.55111 2.77E-06 -2.43334 0.863298 1.01372 0.449833 1.06278

LOC100362321rCG43335-like 0.000822 -2.24069 0.00037 -2.48945 0.315772 1.1806 0.705611 1.06263

Ucp2 uncoupling protein 2 (mitochondrial, proton carrier)2.30E-06 2.1333 3.44E-06 2.05144 0.156211 1.10487 0.369442 1.06248

Zc3h6 zinc finger CCCH type containing 63.31E-05 -3.891 2.03E-05 -4.27585 0.371239 1.16744 0.720871 1.06236

Shpk sedoheptulokinase 5.59E-05 -2.19391 0.001099 -1.65662 0.061981 -1.24658 0.568189 1.06236

LOC679651 hypothetical protein LOC6796516.70E-05 -4.58858 0.000128 -4.01494 0.72639 -1.07604 0.773239 1.06212

Rbp4 retinol binding protein 4, plasma0.0011291 -2.3097 0.00117 -2.29858 0.754453 1.05634 0.733775 1.06145

Kcnq1 potassium voltage-gated channel, KQT-like subfamily, member 19.38E-05 2.47949 0.000132 2.37416 0.43936 1.10831 0.650728 1.06123

Calm1 calmodulin 1 7.73E-06 1.91654 2.76E-06 2.10797 0.59244 -1.03646 0.382233 1.06119

Cerk ceramide kinase 0.0001756 2.15576 8.23E-05 2.35459 0.810882 -1.02936 0.626028 1.06108

Enpep glutamyl aminopeptidase0.0003595 2.00087 0.001563 1.73453 0.12373 1.22387 0.627989 1.06095

Cct8 chaperonin containing Tcp1, subunit 8 (theta)2.71E-06 1.88399 1.06E-06 2.04721 0.669875 -1.02437 0.309904 1.06078

Lgals5 /// Lgals9lectin, galactose binding, soluble 5 /// lectin, galactoside-binding, soluble, 90.917218 -1.02978 0.042763 1.93161 0.050618 -1.87535 0.834918 1.06068

Trappc2 trafficking protein particle complex 23.98E-05 -2.43889 7.90E-05 -2.24754 0.840623 -1.02312 0.607174 1.06062

Ctbp2 C-terminal binding protein 25.42E-05 2.23083 8.24E-05 2.1306 0.341529 1.11017 0.586639 1.06029

Cpne4 copine IV 0.27566 -2.65333 0.109981 -4.47757 0.505203 1.78923 0.94578 1.06027

Dtnbp1 distrobrevin binding protein 13.19E-07 -3.05501 2.60E-07 -3.14634 0.261477 1.09175 0.445304 1.06006

Lypd2 Ly6/Plaur domain containing 25.65E-06 -2.5088 9.51E-06 -2.35837 0.968415 -1.00356 0.52234 1.06001

Pygb phosphorylase, glycogen; brain2.95E-09 -2.89958 1.31E-08 -2.41456 0.011345 -1.133 0.166078 1.0599

Efr3a EFR3 homolog A (S. cerevisiae)6.36E-07 1.82322 1.93E-07 2.01422 0.360175 -1.04233 0.210407 1.05989

LOC691631 Hypothetical protein LOC6916316.11E-07 -2.21282 1.27E-06 -2.05892 0.80891 -1.01415 0.331983 1.05975

Lmo4 LIM domain only 4 1.07E-06 -3.6713 4.15E-06 -2.97166 0.159686 -1.16588 0.574424 1.05967

Limd2 LIM domain containing 23.14E-06 6.35717 8.11E-06 5.10869 0.126742 1.31817 0.731491 1.0593

Ctsc cathepsin C 0.0014294 2.31744 0.000224 3.06144 0.246326 -1.24724 0.753147 1.05918

Selenbp1 selenium binding protein 14.92E-08 -6.7821 2.67E-07 -4.67369 0.012387 -1.37018 0.57444 1.05907

Nap1l1 nucleosome assembly protein 1-like 14.00E-07 2.0907 7.01E-07 1.98543 0.058823 1.11491 0.281023 1.05877

Rbp1 retinol binding protein 1, cellular0.0038793 2.12179 0.011327 1.84654 0.327013 1.21617 0.769794 1.0584

Mmd monocyte to macrophage differentiation-associated0.0007117 2.38525 0.000347 2.63881 0.791942 -1.04559 0.738706 1.05807

of 148 Diabetes

Sptbn2 spectrin, beta, non-erythrocytic 21.17E-07 -2.32546 4.37E-08 -2.60318 0.008074 1.18406 0.278326 1.05774

NR2F2 nuclear receptor subfamily 2, group F, member 21.59E-05 -2.22098 4.48E-05 -1.99812 0.577345 -1.05174 0.542096 1.05685

Tmem97 transmembrane protein 976.14E-05 2.89499 5.10E-05 2.9772 0.849788 1.02763 0.702069 1.05681

Zfp3 zinc finger protein 3 0.0003703 -2.08334 0.001416 -1.81294 0.520376 -1.08754 0.670626 1.05665

CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 157.06E-06 -2.20354 3.24E-05 -1.90139 0.261911 -1.0975 0.500027 1.05595

Wipf1 WAS/WASL interacting protein family, member 12.56E-08 -4.45329 5.93E-08 -3.82787 0.205909 -1.10177 0.461757 1.05593

Ugdh UDP-glucose dehydrogenase2.22E-07 1.75142 3.32E-08 2.04322 0.020316 -1.10568 0.161892 1.0551

Creg1 cellular repressor of E1A-stimulated genes 10.0003905 1.97441 1.16E-05 3.06163 0.010757 -1.47056 0.661425 1.05446

Sult1c3 sulfotransferase family, cytosolic, 1C, member 30.0062707 3.43579 0.004305 3.75477 0.915044 -1.03768 0.881279 1.05316

Gys1 glycogen synthase 1, muscle2.71E-05 1.79252 4.82E-06 2.08882 0.176759 -1.10648 0.469973 1.05316

Pak1ip1 PAK1 interacting protein 13.08E-05 2.04428 1.67E-05 2.17551 0.90508 -1.01054 0.560397 1.0531

Stard13 StAR-related lipid transfer (START) domain containing 130.270958 -1.20063 0.08572 1.35391 0.022922 -1.54366 0.74676 1.05305

G0s2 G0/G1switch 2 0.0051679 7.92796 0.00401 8.7425 0.93387 -1.04764 0.927174 1.0526

Frem3 FRAS1 related extracellular matrix 32.90E-05 -5.22772 1.24E-05 -6.40679 0.22904 1.28983 0.800233 1.05245

Nme4 non-metastatic cells 4, protein expressed in2.56E-06 3.15885 5.06E-06 2.86048 0.164403 1.16199 0.617767 1.05223

Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 22.82E-06 3.62044 2.70E-05 2.58528 0.008275 1.47276 0.662343 1.05167

Steap3 STEAP family member 3 1.44E-07 2.77492 1.01E-06 2.21076 0.001683 1.32 0.425313 1.05163

Cachd1 cache domain containing 10.0016795 1.5693 0.415634 1.08706 0.002644 1.51801 0.619356 1.05153

Sgsm2 small G protein signaling modulator 28.58E-07 -2.14364 1.08E-06 -2.09679 0.631035 1.02855 0.398817 1.05153

Ccnt2 cyclin T2 2.95E-05 -2.1512 2.60E-05 -2.18047 0.50228 1.0658 0.595018 1.05149

LOC100909675uncharacterized LOC1009096756.20E-07 2.16858 1.21E-07 2.59873 0.044322 -1.13973 0.387465 1.05144

Fam148b family with sequence similarity 148, member B1.10E-06 -3.63385 2.03E-06 -3.29329 0.637634 -1.04945 0.62478 1.05142

Nup133 nucleoporin 133 2.95E-07 1.85675 8.30E-08 2.07125 0.175253 -1.06108 0.244801 1.05131

Cxcl14 chemokine (C-X-C motif) ligand 140.0041431 -2.03721 0.008922 -1.85131 0.805331 -1.04677 0.787666 1.05125

Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide1.16E-07 2.25924 1.01E-07 2.29237 0.469395 1.036 0.315027 1.05119

Crygd crystallin, gamma D 0.100149 -2.95516 0.122752 -2.73426 0.96308 -1.02823 0.933962 1.05111

Mrpl40 mitochondrial ribosomal protein L401.92E-05 -2.33487 7.44E-05 -2.01983 0.34446 -1.0998 0.613055 1.05108

Ptplad2 protein tyrosine phosphatase-like A domain containing 26.10E-07 -6.3007 1.63E-06 -5.04978 0.224224 -1.1871 0.712051 1.05106

Id2 inhibitor of DNA binding 20.0042077 -2.5644 0.002999 -2.71824 0.663262 1.11364 0.840918 1.05061

RGD1305222similar to RIKEN cDNA 1810029B161.77E-05 2.4896 7.48E-06 2.7859 0.548592 -1.06512 0.637296 1.0506

Adcy3 adenylate cyclase 3 5.19E-06 2.99545 5.25E-06 2.99057 0.633119 1.0523 0.643867 1.05059

Hmx1 H6 family homeobox 1 0.0148544 -2.2842 0.08427 -1.69301 0.376394 -1.28433 0.858262 1.05051

Lrrc59 leucine rich repeat containing 593.37E-08 3.88697 1.24E-08 4.66842 0.077655 -1.14347 0.479672 1.05035

Mycl1 V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)9.42E-06 -2.35276 8.29E-06 -2.38775 0.485097 1.06556 0.589661 1.04995

Prkar2b protein kinase, cAMP dependent regulatory, type II beta8.03E-06 4.71561 6.90E-06 4.86833 0.917378 1.01662 0.761486 1.04954

of 148Diabetes

LOC100361733rCG57079-like 0.001229 2.56881 0.00101 2.64783 0.92805 1.01819 0.809027 1.04951

Efcab2 EF-hand calcium binding domain 21.21E-06 -2.50365 4.45E-05 -1.762 0.002725 -1.35405 0.516279 1.04938

RGD1311251similar to RIKEN cDNA 4930550C143.00E-05 -2.02613 0.165963 -1.13628 0.000226 -1.69943 0.581975 1.04926

RGD1559690similar to hypothetical protein FLJ254160.0006187 2.15623 0.000149 2.58576 0.372275 -1.14291 0.742489 1.04925

Ift81 intraflagellar transport 81 homolog (Chlamydomonas)3.16E-05 -2.07826 0.000294 -1.7029 0.122009 -1.16326 0.598291 1.04914

Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 25.59E-08 -2.09756 6.92E-08 -2.05624 0.48981 1.0283 0.25018 1.04897

Aldh1a1 aldehyde dehydrogenase 1 family, member A15.49E-06 -6.71611 8.22E-06 -6.07781 0.779369 -1.05344 0.796955 1.04896

Morn1 MORN repeat containing 17.15E-05 -2.11496 0.000434 -1.77836 0.24498 -1.13413 0.648636 1.04862

Trpt1 tRNA phosphotransferase 10.0004441 -2.1416 0.000482 -2.1212 0.784386 1.03839 0.731869 1.04838

Cpsf6 cleavage and polyadenylation specific factor 62.59E-05 -2.40946 2.95E-05 -2.37246 0.765317 1.0321 0.657638 1.0482

Ica1 islet cell autoantigen 1 0.0657606 -1.59155 0.76898 1.06853 0.057275 -1.62262 0.834976 1.04807

Nrg4 neuregulin 4 4.11E-07 -9.81491 5.87E-07 -8.85737 0.724956 -1.05755 0.768775 1.0478

Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 50.0010423 2.02487 0.000454 2.23257 0.722251 -1.05324 0.753578 1.04684

LOC100174910glutaredoxin-like protein2.56E-06 -2.27219 9.48E-06 -1.99315 0.257602 -1.08907 0.532194 1.04676

Adcy6 adenylate cyclase 6 2.07E-06 -2.51061 1.79E-06 -2.55509 0.431542 1.06529 0.566198 1.04675

Ly6e Lymphocyte antigen 6 complex, locus E0.0055013 -1.8869 0.002512 -2.07533 0.427967 1.15119 0.793647 1.04666

Hnrpll heterogeneous nuclear ribonucleoprotein L-like4.22E-06 -2.03498 0.000164 -1.53627 0.006576 -1.26583 0.503029 1.04644

Tmem140 transmembrane protein 1400.0020131 -2.15429 0.004016 -1.97544 0.812528 -1.04273 0.799491 1.04585

Robo2 roundabout, axon guidance receptor, homolog 2 (Drosophila)0.182528 -1.96588 0.01561 -4.12297 0.128488 2.19251 0.925957 1.04541

Amigo2 adhesion molecule with Ig like domain 21.27E-06 -2.95879 2.13E-06 -2.75648 0.761538 -1.02687 0.614051 1.0453

Pank1 pantothenate kinase 1 0.0008962 -2.16715 0.008629 -1.68356 0.204195 -1.23174 0.777483 1.04506

Lpcat1 lysophosphatidylcholine acyltransferase 12.69E-07 4.59488 3.32E-07 4.41113 0.409017 1.08823 0.664154 1.04472

Fh1 fumarate hydratase 1 4.82E-06 2.06569 3.09E-06 2.15822 0.996697 -1.00029 0.535695 1.04449

Macf1 microtubule-actin crosslinking factor 11.80E-06 2.31118 1.29E-05 1.90659 0.008655 1.26577 0.544028 1.04419

Ttyh2 Tweety homolog 2 (Drosophila)6.68E-06 17.8073 9.21E-06 15.7712 0.57132 1.17892 0.880795 1.04412

Anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A9.29E-10 -2.87519 1.30E-09 -2.75107 0.963412 -1.00155 0.229591 1.0435

RGD1564964similar to WD repeat domain 11 protein7.01E-05 -2.16431 2.21E-05 -2.4743 0.127717 1.1915 0.698887 1.04222

RGD1304567similar to RIKEN cDNA A430005L142.00E-06 -3.53069 4.54E-06 -3.10191 0.421473 -1.09224 0.702429 1.04211

RGD1304587similar to RIKEN cDNA 2310033P091.44E-07 -2.40171 1.90E-07 -2.32972 0.839669 1.01082 0.446673 1.04205

RGD1566052similar to elongation protein 4 homolog0.0002395 -2.03885 0.000418 -1.92616 0.891122 -1.01617 0.728595 1.04165

Alox15 arachidonate 15-lipoxygenase1.48E-05 -2.40955 9.60E-05 -1.97089 0.129198 -1.17382 0.678929 1.04153

Upb1 ureidopropionase, beta0.0008515 -2.29605 0.060491 -1.42049 0.02565 -1.55202 0.806816 1.04146

RGD1310951similar to RIKEN cDNA E130308A190.0163586 -1.57876 0.000266 -2.53827 0.00912 1.67431 0.794768 1.04139

Fhit fragile histidine triad gene2.49E-05 -3.21789 5.96E-05 -2.81625 0.510898 -1.09747 0.773119 1.04114

Dhodh dihydroorotate dehydrogenase0.0002259 1.98218 3.99E-05 2.4013 0.19809 -1.16386 0.720563 1.04088

of 148 Diabetes

Got1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)1.04E-06 2.39234 6.72E-07 2.51747 0.869493 -1.01128 0.564322 1.04057

Homez homeobox and leucine zipper encoding0.0024393 -2.01669 0.187027 -1.26185 0.028506 -1.53702 0.814751 1.0398

Lmo7 LIM domain 7 0.0023113 2.32384 0.057106 1.5317 0.045005 1.57723 0.844763 1.0396

Cpsf2 cleavage and polyadenylation specific factor 26.96E-07 1.70151 4.67E-08 2.12091 0.001452 -1.19906 0.340147 1.03956

Osgin1 oxidative stress induced growth inhibitor 11.98E-06 -3.51819 3.30E-06 -3.24174 0.688497 -1.04408 0.718762 1.03946

Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial2.61E-08 2.63467 5.48E-08 2.41436 0.025156 1.134 0.425531 1.03917

Apoe apolipoprotein E 2.20E-07 -4.98486 3.21E-07 -4.61945 0.712438 -1.0388 0.71246 1.0388

Cd63 Cd63 molecule 2.89E-06 8.90246 1.72E-05 5.6005 0.029389 1.65117 0.84599 1.03874

Tubb6 tubulin, beta 6 6.04E-07 4.99431 4.10E-07 5.42476 0.699075 -1.0466 0.752253 1.03783

Traf4af1 TRAF4 associated factor 10.0337781 1.60811 0.002603 2.22417 0.160381 -1.33297 0.847441 1.0376

Fes feline sarcoma oncogene7.53E-06 2.30465 3.33E-06 2.53624 0.493767 -1.06069 0.665797 1.03753

Acot2 acyl-CoA thioesterase 2 1.79E-06 -4.30472 2.21E-06 -4.13821 0.98134 -1.00287 0.766026 1.03726

Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)9.84E-11 4.1717 9.28E-11 4.21595 0.467957 1.02577 0.312512 1.03665

Xpo4 exportin 4 4.74E-05 1.93219 5.88E-06 2.39804 0.062403 -1.19748 0.67876 1.03643

Optn optineurin 0.005304 -1.71835 0.000543 -2.208 0.081271 1.32942 0.817658 1.03461

Myo6 myosin VI 0.761062 -1.05957 0.012127 -1.8098 0.014752 1.76705 0.858106 1.03453

Zmynd11 zinc finger, MYND domain containing 111.35E-06 -2.02368 2.49E-06 -1.91625 0.713962 -1.02121 0.560571 1.03413

Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C1.06E-09 85.4905 1.24E-09 78.2311 0.409513 1.12977 0.818355 1.03384

Trpm3 transient receptor potential cation channel, subfamily M, member 30.021109 -1.9171 0.003344 -2.55257 0.197694 1.37648 0.887429 1.0338

Plaa phospholipase A2, activating protein5.68E-07 1.88584 1.75E-07 2.09169 0.151306 -1.07308 0.478348 1.03362

Armcx3 armadillo repeat containing, X-linked 38.75E-09 22.3692 2.19E-08 15.9165 0.019277 1.4526 0.802685 1.03357

S100a4 S100 calcium-binding protein A42.38E-09 34.0699 2.93E-09 31.1065 0.344596 1.13169 0.797275 1.03325

Col18a1 collagen, type XVIII, alpha 16.83E-09 12.7948 4.50E-09 14.6851 0.330769 -1.11095 0.756778 1.03311

LOC100366237prefoldin subunit 4-like 1.86E-05 1.85809 1.55E-06 2.36769 0.015804 -1.23378 0.651707 1.03281

Tmem54 transmembrane protein 541.33E-06 2.32006 9.27E-07 2.41652 0.896524 -1.00889 0.641433 1.0324

Gnb4 guanine nucleotide binding protein (G protein), beta polypeptide 45.03E-07 7.65983 4.51E-07 7.88617 0.985436 1.00265 0.826772 1.03228

CPD carboxypeptidase D 2.22E-07 -2.55394 1.75E-07 -2.63013 0.324543 1.06304 0.600688 1.03224

Laptm5 lysosomal protein transmembrane 50.0003007 1.98144 0.000181 2.08995 0.851952 -1.02197 0.786453 1.03209

Gpr116 G protein-coupled receptor 1165.87E-06 -4.08505 1.66E-06 -5.27131 0.065026 1.33162 0.82029 1.03195

Sla Src-like adaptor 7.84E-05 -3.00655 0.000188 -2.64057 0.528528 -1.1034 0.838732 1.0319

Emg1 EMG1 nucleolar protein homolog (S. cerevisiae)0.0007888 2.0442 0.000131 2.54948 0.202685 -1.2087 0.824327 1.03183

RGD1560398RGD1560398 5.93E-06 -2.01384 9.12E-05 -1.61836 0.02274 -1.20648 0.655416 1.03141

Tspan7 tetraspanin 7 6.76E-09 5.51867 3.50E-09 6.39796 0.122336 -1.12467 0.667241 1.03082

Pir pirin (iron-binding nuclear protein)1.28E-07 -5.36815 2.57E-07 -4.65063 0.276248 -1.12034 0.766686 1.0303

Lrrn3 leucine rich repeat neuronal 31.48E-07 -34.1543 5.63E-07 -19.5527 0.0348 -1.69612 0.891057 1.02987

of 148Diabetes

Nap1l1 nucleosome assembly protein 1-like 15.43E-07 2.86252 4.95E-07 2.899 0.825907 1.0168 0.699598 1.02975

SLC38A4 solute carrier family 38, member 43.70E-07 4.97235 1.66E-07 5.91769 0.20854 -1.15664 0.795339 1.02894

Tp53i11 tumor protein p53 inducible protein 116.61E-05 4.44305 5.53E-05 4.61325 0.961099 -1.00999 0.892124 1.02804

Spata2 spermatogenesis associated 21.58E-07 -2.2304 3.27E-07 -2.07645 0.383343 -1.04497 0.579666 1.02791

Tnfaip3 tumor necrosis factor, alpha-induced protein 30.0012981 3.5268 0.000863 3.83994 0.830561 -1.05934 0.918838 1.0278

Cenpv centromere protein V 1.97E-07 3.8845 2.03E-07 3.8645 0.704936 1.03311 0.749665 1.02779

Nudt5 nudix (nucleoside diphosphate linked moiety X)-type motif 52.53E-08 2.16025 1.09E-08 2.3547 0.142418 -1.06073 0.473902 1.02761

Lsp1 lymphocyte-specific protein 10.0136815 -2.34449 0.005866 -2.73931 0.519192 1.20034 0.923151 1.02733

Shisa4 shisa homolog 4 (Xenopus laevis)6.17E-06 2.20931 2.93E-05 1.90058 0.047868 1.19396 0.733781 1.02711

RT1-Bb RT1 class II, locus Bb 0.143911 2.13993 0.139601 2.16038 0.972218 1.01702 0.956572 1.02674

Opa1 optic atrophy 1 homolog (human)0.0024289 1.94604 0.001164 2.12157 0.703996 -1.06206 0.86844 1.02649

Fetub fetuin B 0.0001003 -3.6469 0.003734 -2.08443 0.018872 -1.7048 0.890087 1.02627

Ehd2 EH-domain containing 2 2.93E-06 2.68927 9.52E-06 2.32976 0.08466 1.1841 0.774248 1.02581

Cat catalase 3.37E-05 1.88865 6.95E-06 2.19839 0.135497 -1.13576 0.756989 1.02486

CPD carboxypeptidase D 1.69E-08 -2.7086 1.69E-08 -2.70885 0.602585 1.02445 0.603939 1.02435

Hist1h2bc /// Hist1h2bcl1 /// Hist1h2bmhistone cluster 1, H2bc /// histone cluster 1, H2bc-like 1 /// histone cluster 1, H2bm3.15E-08 10.7205 1.98E-08 12.3828 0.325964 -1.12765 0.839595 1.0243

Smc5 structural maintenance of chromosomes 58.24E-06 2.1792 4.08E-06 2.35208 0.512462 -1.05462 0.772871 1.02344

Fat1 FAT tumor suppressor homolog 1 (Drosophila)5.20E-08 2.28211 1.22E-07 2.09532 0.035161 1.11377 0.613634 1.02261

Man2a2 Mannosidase 2, alpha 2 1.13E-05 -2.09886 2.71E-05 -1.93089 0.445071 -1.06382 0.78675 1.02178

Ncf4 neutrophil cytosolic factor 40.0001193 2.55318 0.000131 2.52228 0.809757 1.03417 0.877877 1.02165

Il1b interleukin 1 beta 4.05E-06 18.7203 2.77E-06 21.7835 0.637028 -1.13905 0.937897 1.02157

Cfl2 cofilin 2, muscle 6.26E-07 3.71303 1.30E-07 4.98196 0.018946 -1.31386 0.827183 1.02123

SSBP3 single stranded DNA binding protein 32.00E-07 -2.39928 3.02E-07 -2.29338 0.656598 -1.02507 0.713834 1.02059

Immt inner membrane protein, mitochondrial9.79E-09 2.03561 6.62E-09 2.11044 0.606405 -1.01603 0.515018 1.02041

Tyrobp Tyro protein tyrosine kinase binding protein0.0004002 3.72189 0.000153 4.54913 0.446152 -1.19866 0.933414 1.01969

Efemp1 EGF-containing fibulin-like extracellular matrix protein 17.07E-05 -3.93087 5.33E-05 -4.15389 0.69507 1.07723 0.918992 1.0194

Sox13 SRY (sex determining region Y)-box 138.16E-06 -2.65283 1.27E-05 -2.50758 0.711687 -1.03787 0.848578 1.01932

Acot2 acyl-CoA thioesterase 2 7.59E-05 -2.39585 3.79E-05 -2.61847 0.388342 1.11364 0.877476 1.01896

RGD1559896similar to RIKEN cDNA 2310022B058.41E-08 -1.9516 6.14E-08 -2.0057 0.244178 1.04717 0.622942 1.01893

Klhl23 kelch-like 23 (Drosophila)0.0001413 -2.57777 0.000164 -2.52651 0.992006 -1.00145 0.897183 1.01882

Igf2 insulin-like growth factor 20.0001091 -2.19213 0.001836 -1.66455 0.050352 -1.29287 0.872797 1.01862

LOC500105 similar to contactin associated protein-like 2 isoform a0.0036092 2.10917 0.003809 2.09418 0.893012 1.02582 0.922804 1.01853

Sh2b2 SH2B adaptor protein 2 1.83E-07 4.99046 1.97E-07 4.9158 0.744209 1.03344 0.859362 1.01798

Trpc3 transient receptor potential cation channel, subfamily C, member 30.0002204 -1.93058 3.35E-06 -3.22874 0.00089 1.70218 0.869011 1.01779

Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)1.04E-08 2.82177 8.84E-09 2.88314 0.923089 -1.00436 0.70411 1.01732

of 148 Diabetes

Fam53a family with sequence similarity 53, member A6.55E-05 -1.99811 1.88E-05 -2.27569 0.146686 1.15853 0.856763 1.01721

Pdia5 protein disulfide isomerase family A, member 50.0010111 2.7465 0.000361 3.26998 0.453617 -1.17131 0.937163 1.01647

Fam132a family with sequence similarity 132, member A3.26E-05 5.07754 4.95E-05 4.63414 0.596088 1.11365 0.935572 1.0164

Disp1 dispatched homolog 1 (Drosophila)2.07E-06 -6.12339 2.25E-06 -6.00032 0.97913 -1.00406 0.916584 1.01638

Arl11 ADP-ribosylation factor-like 110.0060361 2.22698 0.004936 2.29591 0.948855 -1.01442 0.942273 1.0163

Trub1 TruB pseudouridine (psi) synthase homolog 1 (E. coli)0.0011182 1.55093 4.77E-05 2.01445 0.024206 -1.27852 0.862995 1.01592

Lrrc42 leucine rich repeat containing 422.46E-05 -2.15754 4.00E-05 -2.05224 0.706784 -1.03523 0.866467 1.01554

Nkain1 Na+/K+ transporting ATPase interacting 11.59E-05 3.19331 3.74E-05 2.80867 0.289542 1.1541 0.908589 1.01509

Mapk12 mitogen-activated protein kinase 121.19E-05 -2.17731 2.20E-05 -2.04706 0.581755 -1.04787 0.859141 1.01504

Tnnt3 troponin T type 3 (skeletal, fast)0.0068487 -1.6248 0.000545 -2.10588 0.075795 1.31508 0.916394 1.01466

Ppt1 palmitoyl-protein thioesterase 11.00E-06 -2.95946 9.06E-06 -2.25132 0.013326 -1.29562 0.863792 1.01461

Hsf2 heat shock transcription factor 25.90E-06 3.18271 8.85E-06 2.99471 0.514938 1.07804 0.900343 1.01436

Syngr1 synaptogyrin 1 0.0001594 -1.78245 4.23E-05 -2.0086 0.162825 1.14274 0.876068 1.01408

Gad1 glutamate decarboxylase 12.44E-08 -41.5477 3.71E-08 -34.251 0.334626 -1.19631 0.938572 1.01398

Slc22a15 solute carrier family 22, member 153.48E-06 2.06884 3.46E-06 2.06988 0.84224 1.01337 0.836359 1.01388

Morn4 MORN repeat containing 48.79E-05 -1.95622 5.92E-05 -2.03289 0.592808 1.05289 0.891034 1.01317

Dpy19l1 dpy-19-like 1 (C. elegans)2.61E-05 2.01983 0.00011 1.77758 0.123718 1.1512 0.877358 1.01313


Fam13c1 family with sequence similarity 13, member C16.80E-06 -6.42359 3.78E-05 -4.3666 0.072624 -1.45231 0.945068 1.01292


Myc myelocytomatosis oncogene0.0003609 3.93423 0.000499 3.68345 0.743474 1.0818 0.957497 1.01284

Muted muted homolog (mouse)3.91E-05 -2.26225 7.15E-05 -2.11737 0.608171 -1.05507 0.903485 1.01266

E2f6 E2F transcription factor 65.81E-06 -2.15676 1.30E-05 -1.99425 0.393682 -1.06809 0.868777 1.01254

Ninl ninein-like 4.21E-05 2.0077 0.001982 1.47803 0.006246 1.37537 0.889447 1.01252

Timm8a1 translocase of inner mitochondrial membrane 8 homolog a1 (yeast)3.33E-08 3.59029 1.42E-08 4.15565 0.063794 -1.14332 0.848406 1.01238

Trib2 tribbles homolog 2 (Drosophila)7.93E-06 -2.90225 5.28E-05 -2.27651 0.060516 -1.25928 0.910087 1.01238

Coro1a coronin, actin binding protein 1A0.0028203 3.14718 0.003943 2.94702 0.781024 1.08076 0.965791 1.01202

Ubash3b ubiquitin associated and SH3 domain containing, B1.90E-06 5.86706 3.40E-06 5.14985 0.357055 1.15237 0.939143 1.0115

Ribc1 RIB43A domain with coiled-coils 10.000291 -2.07223 0.006046 -1.55621 0.05045 -1.3165 0.926415 1.01146

11-Sep septin 11 7.46E-05 -2.28085 0.033732 -1.32869 0.001419 -1.6976 0.922625 1.0112

Nudt13 nudix (nucleoside diphosphate linked moiety X)-type motif 137.70E-06 -2.05238 2.16E-05 -1.8693 0.278761 -1.08595 0.880846 1.01104

RGD1566386similar to Hypothetical protein A430033K040.0067596 -1.8879 0.340525 -1.19457 0.034272 -1.56365 0.953044 1.01072

Myl12b myosin, light chain 12B, regulatory4.17E-08 -2.19339 7.67E-08 -2.06804 0.252656 -1.04975 0.800399 1.01035

LOC100361900hypothetical protein LOC1003619000.0217269 5.2927 0.039263 4.23175 0.700446 1.2634 0.986687 1.01014

Akr1c19 aldo-keto reductase family 1, member C190.0103568 -8.25629 0.010745 -8.12794 0.992932 -1.00581 0.987944 1.00993

of 148Diabetes

Ripk3 receptor-interacting serine-threonine kinase 30.0013999 2.46169 0.000214 3.3322 0.159068 -1.3404 0.959775 1.00987

Grb10 growth factor receptor bound protein 100.0063306 -2.35187 0.798171 -1.06359 0.009913 -2.18971 0.967525 1.00984

Upk1b uroplakin 1B 6.74E-07 -2.00126 5.66E-07 -2.03302 0.632106 1.02505 0.860945 1.00903

Irf5 interferon regulatory factor 50.0004786 2.31093 0.000214 2.57286 0.525016 -1.10344 0.9534 1.00897

Cdr2 cerebellar degeneration-related 22.32E-07 3.94587 9.46E-08 4.66417 0.101586 -1.17178 0.921564 1.00875

Arhgap9 Rho GTPase activating protein 93.66E-05 3.85155 4.03E-05 3.78235 0.875144 1.02704 0.9598 1.00859

Crlf1 cytokine receptor-like factor 11.56E-07 -4.61634 1.72E-07 -4.52914 0.910188 -1.01062 0.927648 1.00854

Zfp385a zinc finger protein 385A 3.80E-06 2.09041 2.90E-05 1.75205 0.023526 1.20309 0.90314 1.00836

Slc16a7 solute carrier family 16, member 7 (monocarboxylic acid transporter 2)1.77E-05 -5.53722 3.69E-05 -4.70176 0.433473 -1.16871 0.968682 1.00769

Rcbtb2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing prot0.0002003 -3.00802 0.000853 -2.42064 0.254916 -1.23332 0.965903 1.00757

Rhov ras homolog gene family, member V0.0002278 2.14916 0.000162 2.23445 0.801763 -1.03192 0.952142 1.00752

RGD1565043similar to Rho guanine nucleotide exchange factor (GEF) 100.0001927 -2.526 0.000141 -2.6366 0.735347 1.05135 0.960972 1.00725

Krt13 keratin 13 2.49E-05 2.34509 2.21E-06 3.25076 0.011885 -1.3764 0.944413 1.00712

Kctd11 potassium channel tetramerisation domain containing 110.0005448 2.06899 0.003557 1.70651 0.167161 1.22049 0.96083 1.00667

LOC502894 hypothetical protein LOC5028943.62E-06 2.17432 9.73E-07 2.51552 0.079433 -1.14945 0.92787 1.0065

Cpd carboxypeptidase D 7.05E-09 -2.61917 2.95E-09 -2.92952 0.015332 1.12563 0.87303 1.00638

Atp6v0e2 ATPase, H+ transporting V0 subunit e24.78E-08 -2.18507 3.99E-08 -2.22505 0.557091 1.02474 0.878318 1.00632

Col18a1 collagen, type XVIII, alpha 10.001049 2.17145 0.000764 2.25994 0.832751 -1.03439 0.96944 1.00614

RGD1309313similar to RIKEN cDNA 4930538D172.98E-06 2.01171 8.06E-07 2.29156 0.075073 -1.13246 0.925667 1.00587

Ppm1j protein phosphatase 1J 6.70E-07 3.43455 5.61E-06 2.54413 0.008548 1.35775 0.949851 1.00575


Atmin ATM interactor 1.31E-05 -1.85716 3.29E-06 -2.10548 0.081236 1.13988 0.936121 1.00544

Ier5l immediate early response 5-like0.0004165 2.59386 0.000236 2.82178 0.645626 -1.08203 0.974765 1.0054

Csrp2 cysteine and glycine-rich protein 21.04E-07 -14.5799 8.00E-08 -15.9704 0.541096 1.10117 0.972964 1.00529

Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit7.35E-06 -2.03795 2.54E-05 -1.82609 0.172368 -1.11033 0.943434 1.00513

Icam1 intercellular adhesion molecule 17.47E-09 28.887 1.89E-08 19.9107 0.023929 1.45794 0.972095 1.00491

C1qc complement component 1, q subcomponent, C chain0.0025384 2.32828 0.00733 2.00847 0.458404 1.16453 0.981969 1.00457

Nat9 N-acetyltransferase 9 (GCN5-related, putative)3.34E-05 -2.48699 7.16E-05 -2.26881 0.44795 -1.09152 0.970062 1.00426

Fam5b family with sequence similarity 5, member B0.0002013 -2.52016 0.121162 -1.28277 0.001595 -1.95665 0.978099 1.00408

Ryr3 ryanodine receptor 3 0.32598 -1.24992 0.017926 -1.88281 0.088423 1.51207 0.986236 1.0038

Galr2 galanin receptor 2 9.53E-05 -2.14956 6.53E-05 -2.2418 0.680951 1.04659 0.974503 1.00353

LOC303590 similar to cactin CG1676-PA0.0013564 -2.18633 0.02914 -1.54082 0.066243 -1.41402 0.983516 1.00348

PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha0.0002983 1.74796 4.21E-05 2.09487 0.089467 -1.1944 0.97144 1.0034

Plcb4 phospholipase C, beta 4 3.90E-09 -5.17392 2.24E-08 -3.73287 0.000735 -1.38139 0.957429 1.00337

Slc35d1 Solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporte8.95E-06 -2.45116 1.29E-05 -2.34689 0.666106 -1.04127 0.974059 1.00303

of 148 Diabetes

TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 11.40E-05 -1.62312 8.36E-07 -2.02062 0.002675 1.2486 0.955768 1.00297

Ivd isovaleryl coenzyme A dehydrogenase8.66E-05 -1.99903 6.70E-05 -2.05075 0.772973 1.02886 0.976426 1.00291

NCOA3 nuclear receptor coactivator 33.83E-06 -2.70368 3.49E-06 -2.73703 0.872771 1.0149 0.978088 1.00254

RGD1307569similar to Protein C21orf63 homolog precursor0.0001919 3.45445 0.001164 2.56285 0.154377 1.35102 0.990627 1.00232

Optn optineurin 9.00E-06 -2.19555 1.17E-06 -2.80105 0.014629 1.27872 0.97761 1.0023

Rg9mtd2 RNA (guanine-9-) methyltransferase domain containing 22.31E-06 2.44593 1.11E-06 2.67691 0.273937 -1.09245 0.98134 1.00182

Asmtl acetylserotonin O-methyltransferase-like0.0002171 -1.96768 0.000125 -2.08286 0.596572 1.06036 0.987467 1.00172

Srgn serglycin 6.06E-05 4.241 1.76E-05 5.5509 0.194613 -1.30687 0.993771 1.00152

Acad11 acyl-Coenzyme A dehydrogenase family, member 111.10E-07 -2.60146 8.90E-08 -2.66996 0.628545 1.02766 0.98157 1.00129

Zfp12 zinc finger protein 12 9.21E-05 -2.35233 0.000155 -2.21261 0.626507 -1.06193 0.992504 1.00115

Memo1 mediator of cell motility 11.28E-07 2.27406 1.30E-07 2.27034 0.957132 1.00264 0.983742 1.001

HLF hepatic leukemia factor 9.89E-07 -15.4788 6.62E-07 -17.9209 0.495114 1.1589 0.996359 1.00097

Tc2n tandem C2 domains, nuclear1.01E-07 -6.80707 1.50E-07 -6.18987 0.405433 -1.09912 0.996112 1.00054

RGD1562012RGD1562012 5.50E-09 -2.73188 5.66E-08 -2.11205 0.000171 -1.29288 0.990865 1.00046

Htra3 HtrA serine peptidase 30.0001493 -2.03156 2.17E-05 -2.53104 0.070852 1.24556 0.998204 -1.00024

Clic2 chloride intracellular channel 20.0777311 -2.02171 0.005149 -3.76831 0.111532 1.86332 0.999283 -1.00032

Plxna2 plexin A2 5.42E-06 -2.32993 4.89E-06 -2.35734 0.891085 1.01133 0.995772 -1.00044

Dkk3 dickkopf homolog 3 (Xenopus laevis)8.82E-07 -7.27949 6.03E-07 -8.04886 0.516597 1.10512 0.997299 -1.00051

Ccdc74a coiled-coil domain containing 74A0.0002103 2.83224 0.000355 2.61986 0.647293 1.08045 0.997264 -1.00058

Neo1 neogenin homolog 1 (chicken)1.17E-06 -3.85951 9.14E-07 -4.03387 0.687669 1.04431 0.993808 -1.00083

Marcks myristoylated alanine rich protein kinase C substrate9.42E-06 2.0084 2.00E-06 2.35417 0.053845 -1.17317 0.99057 -1.00086

Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain5.32E-07 24.0793 9.97E-07 18.7729 0.2948 1.28129 0.996246 -1.00107

Hdac11 histone deacetylase 11 4.09E-05 -2.77959 0.000118 -2.41242 0.290832 -1.15396 0.990695 -1.00152

Atg2a ATG2 autophagy related 2 homolog A (S. cerevisiae)2.73E-05 -2.00532 1.92E-05 -2.07551 0.698448 1.03328 0.984156 -1.00167

Nrcam neuronal cell adhesion molecule4.00E-06 -2.91798 0.126695 -1.17956 1.38E-05 -2.47794 0.98657 -1.00168

Slco3a1 solute carrier organic anion transporter family, member 3a10.0004497 -2.93556 0.000118 -3.71124 0.252369 1.26199 0.992709 -1.00178

Ssx2ip synovial sarcoma, X breakpoint 2 interacting protein2.30E-08 -2.91645 4.07E-08 -2.70623 0.16245 -1.0796 0.972321 -1.00178

Nme2 non-metastatic cells 2, protein (NM23B) expressed in3.55E-09 2.31808 2.16E-09 2.44773 0.104427 -1.05814 0.947696 -1.00209

LOC689176 similar to transmembrane protein 643.13E-05 -2.62276 0.000234 -2.06444 0.069056 -1.27329 0.984982 -1.00224

Sox7 SRY (sex determining region Y)-box 73.73E-08 13.0922 1.38E-07 8.8123 0.014868 1.48157 0.983207 -1.00277

Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial2.68E-05 5.03439 1.84E-05 5.48178 0.653771 -1.09195 0.988423 -1.00283

Ptprj protein tyrosine phosphatase, receptor type, J0.000154 -2.98779 4.98E-05 -3.61414 0.285743 1.20573 0.984726 -1.00324

Lrfn4 leucine rich repeat and fibronectin type III domain containing 47.03E-06 2.76005 1.85E-05 2.43846 0.258096 1.12809 0.973817 -1.00336

Htra1 HtrA serine peptidase 1 1.22E-07 3.48407 6.54E-08 3.86491 0.174051 -1.11307 0.963568 -1.00339

Slc39a8 solute carrier family 39 (zinc transporter), member 87.62E-05 8.26249 0.000171 6.55883 0.448683 1.25523 0.990256 -1.0036

of 148Diabetes

Dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 101.37E-05 2.17858 2.25E-05 2.07157 0.591421 1.04754 0.963478 -1.00393

Dnajc4 DnaJ (Hsp40) homolog, subfamily C, member 42.09E-07 -2.07907 3.30E-07 -1.99418 0.34008 -1.04682 0.930353 -1.00408

Zbtb4 zinc finger and BTB domain containing 40.0053568 -1.71861 0.001025 -2.05156 0.26145 1.18875 0.977425 -1.00419

Trpv2 transient receptor potential cation channel, subfamily V, member 27.46E-05 2.00292 3.75E-05 2.14832 0.449693 -1.07721 0.964512 -1.00431

Jrk jerky homolog (mouse)0.0003229 -2.12227 0.007986 -1.55247 0.035301 -1.37317 0.972354 -1.00449

LOC688163 hypothetical protein LOC6881631.33E-06 -6.68109 2.85E-06 -5.58002 0.249632 -1.20273 0.976568 -1.00452

Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 35.46E-06 -2.05384 6.30E-06 -2.02613 0.794147 -1.01848 0.946203 -1.00474

Dock1 dedicator of cyto-kinesis 11.86E-06 -1.90839 7.69E-07 -2.06485 0.202868 1.07606 0.919802 -1.00551

Arid1b AT rich interactive domain 1B (Swi1 like)1.06E-06 -2.16715 2.57E-06 -1.99147 0.163822 -1.09429 0.926913 -1.00558

Tmsb10 thymosin, beta 10 1.75E-07 4.4638 1.79E-07 4.44386 0.987324 -1.00148 0.94893 -1.00597

Homer3 Homer homolog 3 (Drosophila)0.0006548 1.96932 0.000152 2.3236 0.209613 -1.18717 0.962217 -1.00617

Zc3h8 zinc finger CCCH type containing 82.70E-05 -2.02601 2.16E-05 -2.07051 0.859056 1.01526 0.938445 -1.0066

Rassf6 Ras association (RalGDS/AF-6) domain family member 65.86E-05 1.97035 2.25E-05 2.16887 0.27763 -1.10838 0.939633 -1.00693

Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)5.38E-05 -6.60386 3.45E-05 -7.4484 0.652988 1.1201 0.977957 -1.00695

Diaph3 diaphanous homolog 3 (Drosophila)0.0042183 1.58705 0.000244 2.07726 0.045598 -1.31829 0.952597 -1.00719

Rerg RAS-like, estrogen-regulated, growth-inhibitor0.0002167 -2.03231 0.000145 -2.12064 0.761729 1.03557 0.947308 -1.00762

Vamp5 vesicle-associated membrane protein 52.78E-07 11.0269 3.48E-07 10.3002 0.70338 1.06244 0.96167 -1.00764

Arl4c ADP-ribosylation factor-like 4C1.89E-06 5.41374 3.06E-06 4.8812 0.509094 1.10039 0.955986 -1.00791

Tk2 thymidine kinase 2, mitochondrial3.19E-06 -2.37503 1.21E-06 -2.67117 0.188964 1.11525 0.914382 -1.00846

Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like5.56E-05 -2.73274 7.22E-05 -2.63556 0.739326 -1.04579 0.949052 -1.00861

Bbs4 Bardet-Biedl syndrome 45.07E-05 -2.04531 0.000116 -1.8904 0.363312 -1.09201 0.921705 -1.00931

Tmem106b transmembrane protein 106B2.72E-06 -2.00516 1.28E-05 -1.76151 0.048506 -1.14928 0.876689 -1.00963

Reep5 receptor accessory protein 55.36E-06 -2.44665 9.11E-06 -2.30166 0.424693 -1.07335 0.911088 -1.00975


Sfxn1 sideroflexin 1 2.21E-06 2.03382 2.20E-07 2.60663 0.002443 -1.29496 0.866214 -1.01039

Pdgfra platelet derived growth factor receptor, alpha polypeptide0.0041464 -2.43681 0.087634 -1.54798 0.072641 -1.59066 0.964185 -1.01046

LOC361346 similar to chromosome 18 open reading frame 541.95E-06 4.32398 3.99E-06 3.78938 0.34257 1.12924 0.933133 -1.01049

Ngef neuronal guanine nucleotide exchange factor2.29E-05 -1.77754 4.62E-06 -2.04104 0.088206 1.13622 0.876875 -1.01058

Cyp2j10 cytochrome P450, family 2, subfamily j, polypeptide 105.39E-05 2.81353 1.29E-05 3.5221 0.113785 -1.26662 0.931938 -1.0118

Decr1 2,4-dienoyl CoA reductase 1, mitochondrial0.0001278 -2.66046 0.000161 -2.57682 0.76366 -1.04528 0.933058 -1.01241

Pdcd4 programmed cell death 42.63E-07 -2.16055 7.83E-06 -1.63937 0.00036 -1.33476 0.80171 -1.01278

Syt17 synaptotagmin XVII 0.0012684 -2.5485 0.000531 -2.92472 0.535418 1.13298 0.948517 -1.01293

Sh3rf1 SH3 domain containing ring finger 10.000497 -3.50088 0.000164 -4.38517 0.369875 1.23582 0.953258 -1.01357

Pnpla7 patatin-like phospholipase domain containing 71.57E-06 -2.12529 1.52E-06 -2.13261 0.869489 -1.01029 0.82641 -1.01376

Sel1l3 Sel-1 suppressor of lin-12-like 3 (C. elegans)3.16E-05 -2.63162 2.64E-05 -2.69653 0.929761 1.01058 0.907669 -1.01394

of 148 Diabetes

Ubl7 Ubiquitin-like 7 (bone marrow stromal cell-derived)2.99E-05 -2.40729 3.00E-05 -2.40632 0.887713 -1.01531 0.89066 -1.0149

Tpm3 Tropomyosin 3, gamma 1.27E-08 3.24737 5.40E-09 3.71323 0.01868 -1.16103 0.771543 -1.01537

Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a8.88E-07 -2.56798 1.65E-07 -3.22739 0.016089 1.23725 0.828669 -1.01579

Nrarp Notch-regulated ankyrin repeat protein6.38E-07 2.59641 1.82E-07 3.06951 0.027135 -1.20106 0.821638 -1.01594

Giot1 gonadotropin inducible ovarian transcription factor 13.16E-05 -2.80707 0.0002 -2.2135 0.074085 -1.28838 0.901155 -1.01594

Vps37b vacuolar protein sorting 37 homolog B (S. cerevisiae)0.515299 1.10223 0.049847 -1.39101 0.020577 1.50913 0.91457 -1.01596

Cmah cytidine monophosphate-N-acetylneuraminic acid hydroxylase4.56E-05 -2.53792 0.010844 -1.47196 0.001374 -1.75234 0.893356 -1.01634

FAM120C Family with sequence similarity 120C1.94E-07 -4.02363 3.46E-07 -3.64343 0.210417 -1.12269 0.851191 -1.0166

Myh14 myosin, heavy chain 14 1.24E-07 -3.1708 8.27E-08 -3.37262 0.516172 1.04622 0.8101 -1.01666

Fkbp1a FK506 binding protein 1a4.42E-10 4.60503 1.07E-09 3.92037 0.010348 1.15451 0.698844 -1.01744

Fgfbp3 fibroblast growth factor binding protein 30.0001609 -1.96819 3.44E-05 -2.32096 0.18672 1.1584 0.865396 -1.01798

Bcl11b B-cell CLL/lymphoma 11B (zinc finger protein)6.88E-05 2.05138 0.008156 1.39701 0.005058 1.44195 0.854067 -1.01835

Shroom3 shroom family member 30.000104 2.05912 0.017831 1.35407 0.00436 1.49306 0.861836 -1.0185

Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit1.99E-05 -2.47166 9.80E-06 -2.70701 0.494727 1.07533 0.861195 -1.0185

Slc39a14 solute carrier family 39 (zinc transporter), member 145.70E-07 5.04228 1.55E-06 4.13848 0.153291 1.19602 0.874308 -1.0187

S100a1 S100 calcium binding protein A10.0003754 -2.01258 0.003305 -1.63583 0.093717 -1.25445 0.874567 -1.01962

PCNX pecanex homolog (Drosophila)1.55E-06 -2.28834 2.30E-05 -1.78183 0.003518 -1.30979 0.773444 -1.01988

Phf7 PHD finger protein 7 1.81E-06 -2.31349 1.06E-06 -2.4592 0.570328 1.04129 0.770605 -1.02084

Armc6 armadillo repeat containing 69.46E-06 2.24659 1.13E-05 2.20512 0.979821 -1.00215 0.806677 -1.02099

Rbm43 RNA binding motif protein 430.0008256 -2.02286 0.000228 -2.35505 0.363429 1.13956 0.878439 -1.02164

Lgals7 lectin, galactoside-binding, soluble, 70.0053194 3.18616 0.000357 6.09747 0.059694 -1.95527 0.945761 -1.0217

Plekha8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) mem6.29E-05 -2.21695 6.79E-05 -2.19795 0.77995 -1.03072 0.841371 -1.02189

Bcl2l14 Bcl2-like 14 (apoptosis facilitator)0.0004774 -2.06636 0.023882 -1.42876 0.01592 -1.47812 0.869357 -1.02203

Mboat1 membrane bound O-acyltransferase domain containing 19.58E-09 3.35786 1.05E-08 3.31246 0.874893 -1.00823 0.67672 -1.02204

Lrtomt leucine rich transmembrane and 0-methyltransferase domain containing1.47E-06 -3.35799 4.07E-05 -2.17281 0.001429 -1.57956 0.825969 -1.02207

Mpnd MPN domain containing 1.71E-09 -2.02555 7.14E-10 -2.1984 0.035537 1.06146 0.373976 -1.02249

Rrbp1 ribosome binding protein 16.18E-08 3.88587 9.93E-08 3.58815 0.446394 1.05898 0.7623 -1.02265

Zfp187 zinc finger protein 187 5.57E-07 -2.16412 3.97E-07 -2.24044 0.827689 1.01222 0.687592 -1.02277

Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)0.0014412 1.78904 0.000151 2.27388 0.064455 -1.29996 0.858602 -1.02278

Tmco6 transmembrane and coiled-coil domains 67.89E-05 -2.13328 7.47E-05 -2.14584 0.875331 -1.01681 0.83209 -1.0228

Rab13 RAB13, member RAS oncogene family2.94E-05 2.106 2.46E-05 2.14509 0.653426 -1.04195 0.803207 -1.02296

Dnajc22 DnaJ (Hsp40) homolog, subfamily C, member 220.0001717 2.21655 8.59E-05 2.40879 0.406154 -1.11177 0.855187 -1.02304

RGD1564114similar to FLJ46082 protein0.0010935 -2.08638 0.151026 -1.26484 0.007631 -1.68827 0.879198 -1.02349

Sostdc1 sclerostin domain containing 17.78E-05 -6.49512 9.41E-05 -6.17801 0.779871 -1.07606 0.92921 -1.02352

Fhl3 four and a half LIM domains 32.60E-06 4.1702 5.58E-06 3.63544 0.378442 1.12052 0.852466 -1.02372

of 148Diabetes

Xrcc6bp1 XRCC6 binding protein 13.48E-05 -2.1617 1.70E-05 -2.33989 0.569743 1.0569 0.804727 -1.02415

Rsbn1 round spermatid basic protein 11.09E-06 -2.02833 2.52E-06 -1.88517 0.108862 -1.10226 0.666086 -1.02447

Vezf1 Vascular endothelial zinc finger 19.54E-07 -3.76412 4.51E-07 -4.3082 0.297225 1.11717 0.813625 -1.02451

Xkr4 XK, Kell blood group complex subunit-related family, member 40.0101126 -2.05189 0.038055 -1.70343 0.355579 -1.23429 0.912385 -1.02468

Xpo4 exportin 4 2.22E-06 2.74323 4.56E-07 3.45457 0.016493 -1.29084 0.777127 -1.02504

Lrp4 low density lipoprotein receptor-related protein 42.81E-05 -4.13636 1.70E-05 -4.57823 0.658209 1.07975 0.885786 -1.02508

Car12 Carbonic anyhydrase 12 1.02E-11 316.135 1.25E-11 273.911 0.276709 1.12551 0.810334 -1.02545

Hsf2 heat shock transcription factor 27.66E-07 2.06092 1.23E-06 1.9737 0.74967 1.01756 0.637065 -1.02617

Osbpl9 oxysterol binding protein-like 96.11E-08 -2.8476 1.14E-07 -2.6298 0.092041 -1.11119 0.651352 -1.0262

Dync2h1 dynein cytoplasmic 2 heavy chain 11.14E-06 -2.13726 1.15E-06 -2.13507 0.653588 -1.02753 0.665709 -1.02648

LOC503192 Zinc finger protein ZFP 3.27E-07 -2.73569 1.11E-06 -2.36128 0.029733 -1.18936 0.700107 -1.02658


Litaf lipopolysaccharide-induced TNF factor1.55E-07 2.57044 3.61E-07 2.33276 0.244803 1.07281 0.645699 -1.0271

ESRP1 epithelial splicing regulatory protein 13.55E-07 -1.99427 1.99E-07 -2.10355 0.576129 1.02689 0.572279 -1.02717

Actn1 actinin, alpha 1 1.42E-09 33.1291 1.60E-09 31.4771 0.837217 1.0246 0.820452 -1.02722

Leprotl1 leptin receptor overlapping transcript-like 14.94E-05 4.22612 0.000361 2.94964 0.107472 1.39403 0.884846 -1.02778

Frrs1 ferric-chelate reductase 16.41E-05 2.90012 1.02E-05 3.93773 0.044977 -1.39567 0.849518 -1.0279

Lpar6 lysophosphatidic acid receptor 66.43E-05 -2.39411 3.62E-05 -2.57496 0.704783 1.04628 0.816787 -1.02797

Mrps15 mitochondrial ribosomal protein S158.22E-06 2.09582 3.22E-06 2.31232 0.125607 -1.13429 0.716741 -1.02809

Slc31a1 solute carrier family 31 (copper transporters), member 12.08E-07 2.17539 8.85E-08 2.37939 0.039639 -1.12464 0.576928 -1.02821

Cep19 centrosomal protein 190.0005202 -2.70959 0.000329 -2.91043 0.816161 1.04383 0.876654 -1.02902

Hint2 histidine triad nucleotide binding protein 23.41E-09 -2.00545 4.04E-09 -1.97636 0.127356 -1.04418 0.292725 -1.02904

Scx scleraxis 0.0001391 -2.27049 0.000569 -1.94456 0.166683 -1.20164 0.817912 -1.02915

LOC100360671hypothetical protein LOC1003606710.0007386 -2.02151 0.000184 -2.38165 0.33974 1.14466 0.833861 -1.02926

Nfkbie Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon1.08E-05 2.87177 2.04E-05 2.63347 0.610524 1.05946 0.797836 -1.02928

SORBS1 sorbin and SH3 domain containing 10.0003223 -1.89631 0.000176 -2.01301 0.779952 1.03128 0.793042 -1.02934

Nr3c2 nuclear receptor subfamily 3, group C, member 20.0005978 -1.83411 0.405261 -1.10242 0.001274 -1.71281 0.799917 -1.02951

Tmem97 transmembrane protein 970.000361 2.65959 0.000318 2.71042 0.779 -1.04928 0.86465 -1.0296

Slc25a36 solute carrier family 25, member 362.05E-05 -1.67934 1.57E-06 -2.07412 0.01446 1.19904 0.625634 -1.03006

Fbxo16 F-box protein 16 0.00014 -2.15768 0.031553 -1.34292 0.002152 -1.6551 0.800104 -1.03012

S100a6 S100 calcium binding protein A61.51E-07 4.3572 8.10E-07 3.27081 0.018335 1.29287 0.739637 -1.03038

RGD1309540similar to hypothetical protein MGC40841; similar to hypothetical protein MGC47070.0191459 -1.64407 0.003328 -2.01558 0.336681 1.18972 0.864214 -1.03047

Mms22l MMS22-like, DNA repair protein0.0034229 1.79938 0.000978 2.06328 0.27682 -1.18185 0.838096 -1.03068

RGD1565496similar to Butyrate-induced transcript 11.94E-05 2.23624 6.00E-05 1.99112 0.368357 1.08957 0.74482 -1.03078

Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 15.76E-06 2.24204 1.00E-05 2.1168 0.735951 1.02713 0.699227 -1.03119

of 148 Diabetes

LOC688459 /// LOC688548hypothetical protein LOC688459 /// hypothetical protein LOC6885480.0002648 3.79852 0.000131 4.39038 0.439219 -1.19214 0.889589 -1.03143

Zfp709 zinc finger protein 709 0.0005483 -2.07277 0.002965 -1.73976 0.155736 -1.22903 0.819179 -1.03158

Matn2 matrilin 2 8.24E-06 -3.20597 1.56E-06 -4.27086 0.058756 1.2912 0.794632 -1.03172

Ankrd28 ankyrin repeat domain 288.22E-07 -1.88486 3.53E-07 -2.02824 0.396749 1.04261 0.517129 -1.03209

Prr12 proline rich 12 1.26E-05 -2.11965 1.69E-05 -2.0589 0.462527 -1.06307 0.69631 -1.0326

Gli4 GLI family zinc finger 4 8.53E-06 -2.04506 5.67E-06 -2.1285 0.915458 1.00787 0.665305 -1.03267

Rag1ap1 recombination activating gene 1 activating protein 10.0003279 -2.00967 0.00108 -1.78688 0.234306 -1.16177 0.787828 -1.03297

Gmpr guanosine monophosphate reductase8.95E-07 -2.46862 1.45E-05 -1.86808 0.001678 -1.36532 0.640097 -1.03318

Cml5 camello-like 5 5.10E-07 -16.3211 2.08E-06 -10.229 0.032134 -1.64856 0.869789 -1.03322

Nefh neurofilament, heavy polypeptide0.0006803 2.97042 0.002447 2.42058 0.422215 1.18757 0.875846 -1.03333

MAPK9 mitogen-activated protein kinase 91.76E-06 -1.90807 9.92E-07 -2.00656 0.748634 1.01756 0.547913 -1.03347

LOC690000 Similar to CG3740-PA 8.31E-07 -4.45182 1.10E-06 -4.21821 0.452247 -1.09077 0.771902 -1.03353

Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 15.55E-08 2.0878 1.26E-07 1.94008 0.33376 1.04017 0.400427 -1.03458

Gkn1 gastrokine 1 1.77E-06 -3.79131 5.88E-05 -2.2965 0.001133 -1.708 0.761669 -1.03458

Ly6e lymphocyte antigen 6 complex, locus E0.0040381 -2.60295 0.011375 -2.19219 0.41637 -1.22848 0.890788 -1.03462

Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 33.06E-07 11.0083 2.28E-07 12.071 0.436964 -1.13543 0.827962 -1.03547

Pkia Protein kinase (cAMP-dependent, catalytic) inhibitor alpha0.0157151 1.6311 0.001685 2.09979 0.109782 -1.3339 0.830052 -1.03616

Dlx5 distal-less homeobox 5 4.51E-06 -2.7535 4.91E-07 -3.87158 0.01122 1.3569 0.712298 -1.03622

Sh3tc1 SH3 domain and tetratricopeptide repeats 11.69E-06 -9.52389 6.75E-06 -6.53247 0.053085 -1.51097 0.849249 -1.03638

MYO1B myosin IB 1.49E-06 -2.28592 1.12E-06 -2.36012 0.953966 -1.00392 0.600203 -1.03651

RGD1305899similar to Protein C20orf1583.72E-05 2.38218 8.29E-05 2.17281 0.612 1.05761 0.743334 -1.03664

Homer1 homer homolog 1 (Drosophila)0.0004273 2.26684 6.78E-05 2.91569 0.077515 -1.33372 0.805276 -1.03691

Klf13 Kruppel-like factor 13 4.16E-07 2.78289 8.91E-07 2.52805 0.413209 1.06129 0.610221 -1.03723

Entpd2 ectonucleoside triphosphate diphosphohydrolase 21.96E-05 2.39424 4.24E-05 2.19253 0.614359 1.05256 0.716428 -1.03747

Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 64.85E-07 4.7864 8.11E-07 4.32769 0.570934 1.0656 0.738321 -1.0379

Dbp D site of albumin promoter (albumin D-box) binding protein9.36E-06 -7.40163 1.93E-05 -6.14533 0.302886 -1.25021 0.858639 -1.03801

Ddx26b DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B0.0007344 -2.60243 0.00035 -2.92003 0.679095 1.08064 0.840392 -1.03831

Echdc3 enoyl Coenzyme A hydratase domain containing 37.60E-06 -2.7283 2.98E-05 -2.3029 0.068947 -1.23079 0.709763 -1.03888

Cxcl3 chemokine (C-X-C motif) ligand 32.95E-05 15.4894 3.25E-05 14.9337 0.994985 -1.00211 0.908138 -1.0394

Zfp275 zinc finger protein 275 1.49E-05 2.76593 1.76E-07 6.17981 5.87E-05 -2.32256 0.73313 -1.03952

Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi4.33E-08 114.156 5.56E-08 98.3153 0.655758 1.11683 0.874613 -1.03966

Wwc1 WW and C2 domain containing 19.10E-06 -2.25835 4.90E-05 -1.9104 0.03644 -1.22911 0.648227 -1.03974

Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)1.35E-06 2.08374 2.94E-06 1.94094 0.596827 1.03224 0.514827 -1.04004

Lsamp limbic system-associated membrane protein4.79E-05 -4.78099 6.99E-05 -4.41059 0.561601 -1.12746 0.84761 -1.04011

Swap70 SWAP switching B-cell complex 700.0052429 1.91478 0.000241 2.92108 0.026991 -1.58725 0.822446 -1.04045

of 148Diabetes

Ky kyphoscoliosis peptidase0.0022348 -1.89473 0.127951 -1.27846 0.017243 -1.54201 0.790911 -1.04046

Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD)0.0091676 2.16266 0.007854 2.2147 0.784031 -1.06613 0.862987 -1.04108

Hmga2 high mobility group AT-hook 20.0004791 2.15582 0.002316 1.81577 0.362482 1.14019 0.773431 -1.04129

Arl6ip5 ADP-ribosylation-like factor 6 interacting protein 52.52E-06 -2.00758 5.56E-06 -1.87294 0.100689 -1.1163 0.512922 -1.04144

Txndc17 Thioredoxin domain containing 170.0001444 -1.9023 6.96E-05 -2.04136 0.761244 1.03039 0.680895 -1.04146

Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.0001195 2.08145 0.00078 1.73981 0.226028 1.14857 0.70952 -1.04161

Zfp385b zinc finger protein 385B 8.25E-06 -3.40116 0.000225 -2.16477 0.003722 -1.63713 0.744521 -1.042

Plekhn1 pleckstrin homology domain containing, family N member 11.42E-06 -2.00729 1.15E-06 -2.04716 0.704695 -1.02184 0.474514 -1.04214

Plcd3 phospholipase C, delta 30.0002139 2.50408 0.002098 1.90118 0.142784 1.26347 0.779971 -1.04246

Gcnt2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme3.18E-05 13.6637 2.46E-05 15.0056 0.676352 -1.1451 0.896951 -1.04271

LOC312502 similar to RAB11 family interacting protein 5 (class I) isoform 11.63E-05 3.23753 2.79E-05 2.9776 0.754874 1.04231 0.750224 -1.04316

Letm1 leucine zipper-EF-hand containing transmembrane protein 12.33E-05 1.91933 9.71E-06 2.08379 0.134461 -1.13256 0.587354 -1.04317

LOC100359980smooth muscle and non-muscle myosin alkali light chain 6B-like4.82E-06 -2.24725 9.36E-07 -2.72933 0.079059 1.16307 0.580144 -1.04424

Arhgap1 Rho GTPase activating protein 10.0083032 -1.54225 0.000318 -2.11376 0.060422 1.31242 0.736596 -1.0443

Cst6 cystatin E/M 1.74E-08 -3.08308 1.27E-08 -3.22633 0.968515 1.00206 0.415883 -1.04431

HSDL1 hydroxysteroid dehydrogenase like 10.0108531 -1.63215 0.001354 -2.03934 0.261534 1.1964 0.777357 -1.04437

Hck hemopoietic cell kinase0.0028219 2.28557 0.001078 2.63843 0.364143 -1.20611 0.827586 -1.04481

Oaf OAF homolog (Drosophila)2.26E-06 3.46576 2.68E-06 3.37351 0.87436 -1.01718 0.684231 -1.04499

Apobec3f apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F2.52E-06 2.38392 1.77E-06 2.4847 0.281421 -1.08918 0.568144 -1.04501

Ampd2 adenosine monophosphate deaminase 2 (isoform L)2.69E-06 2.05459 1.55E-05 1.76823 0.124913 1.11179 0.495782 -1.04511

Cirbp cold inducible RNA binding protein3.66E-09 -4.01248 3.11E-09 -4.13016 0.771252 -1.01552 0.411948 -1.0453

Msl2l1 Male-specific lethal 2-like 1 (Drosophila)0.0011516 -2.0257 0.000376 -2.31636 0.549712 1.09357 0.763266 -1.04565

Pdia6 protein disulfide isomerase family A, member 69.07E-08 2.12303 1.35E-07 2.04483 0.861371 -1.00755 0.311365 -1.04608

Mlec malectin 9.66E-07 3.35471 3.43E-07 3.98956 0.042948 -1.24413 0.632914 -1.04616

Cxcl3 chemokine (C-X-C motif) ligand 34.46E-06 27.3117 5.84E-06 24.3244 0.822414 1.07295 0.884769 -1.04647

Arhgap24 Rho GTPase activating protein 240.0014095 -2.10222 0.001244 -2.13456 0.851291 -1.03062 0.777988 -1.04648

Znf467 zinc finger protein 467 1.48E-05 -2.51321 8.38E-06 -2.70376 0.792674 1.02735 0.654865 -1.04717

11-Sep Septin 11 0.0048451 -1.70336 0.143873 1.25088 0.0004 -2.23184 0.745777 -1.04747

Ccr1 chemokine (C-C motif) receptor 19.72E-05 2.82821 0.000124 2.72791 0.943098 -1.01077 0.755749 -1.04793

Znf763 zinc finger protein 763 0.0001445 -2.82636 8.81E-05 -3.05019 0.854039 1.02966 0.767831 -1.04811


Synpr synaptoporin 0.0004963 -2.24587 0.000488 -2.25067 0.762186 -1.04608 0.751338 -1.04832

Vegfa vascular endothelial growth factor A0.0001372 5.89158 0.000914 3.79218 0.16989 1.48161 0.860059 -1.0486

Adfp Adipose differentiation related protein2.19E-05 2.09518 4.30E-05 1.96191 0.836037 1.01814 0.58558 -1.04891

Ivns1abp influenza virus NS1A binding protein1.14E-07 -3.31328 8.70E-08 -3.45437 0.931279 -1.00609 0.503924 -1.04894

of 148 Diabetes

Smoc2 SPARC related modular calcium binding 27.41E-08 48.261 8.27E-08 45.7304 0.978622 1.0058 0.824001 -1.04925

CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit7.49E-06 -3.04998 2.58E-06 -3.61245 0.305063 1.12769 0.666406 -1.0503

CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit7.49E-06 -3.04998 2.58E-06 -3.61245 0.305063 1.12769 0.666406 -1.0503

Pcdha1 /// Pcdha10 /// Pcdha11 /// Pcdha12 /// Pcdha13 /// Pcdha2 /// Pcdha3 /// Pcdha4 /// Pcdha5 /// Pcdha6 /// Pcdha7 /// Pcdha8 /// Pcdha9 /// Pcdhac1 /// Pcdhac2protocadherin alpha 1 /// protocadherin alpha 10 /// protocadherin alpha 11 /// protoca0.0020927 -2.2121 0.000134 -3.3663 0.070468 1.44885 0.789351 -1.05033

Bri3bp Bri3 binding protein 5.77E-06 2.454 5.84E-06 2.45019 0.588037 -1.04928 0.576287 -1.05091

Sbsn suprabasin 2.57E-05 4.96189 0.000197 3.32434 0.096213 1.42009 0.795788 -1.05106

Ada adenosine deaminase 1.05E-07 2.57348 3.44E-07 2.25123 0.156043 1.08706 0.373051 -1.05159

Ppp1r3c protein phosphatase 1, regulatory (inhibitor) subunit 3C3.21E-06 -11.6658 3.64E-06 -11.2026 0.684309 -1.09532 0.820821 -1.05183

Nlk nemo like kinase 3.71E-07 -2.41596 1.23E-07 -2.76246 0.191896 1.08697 0.412102 -1.05193

Epb4.1l2 erythrocyte membrane protein band 4.1-like 21.43E-06 4.77405 4.83E-07 6.04965 0.048295 -1.33333 0.691344 -1.05219

Cd47 Cd47 molecule 3.13E-05 2.91714 6.08E-05 2.65465 0.744142 1.04413 0.69974 -1.05243

KLHL12 kelch-like 12 (Drosophila)5.46E-06 -2.04309 1.12E-05 -1.91337 0.121176 -1.12389 0.469041 -1.05253

KLHL12 kelch-like 12 (Drosophila)5.46E-06 -2.04309 1.12E-05 -1.91337 0.121176 -1.12389 0.469041 -1.05253

Mir23b microRNA mir-23b 0.0390085 -1.64196 0.003738 -2.25379 0.223619 1.30392 0.80497 -1.05269

Zbtb48 zinc finger and BTB domain containing 481.10E-05 -2.38766 6.03E-06 -2.56732 0.820158 1.02139 0.584019 -1.05273

Eif4e2 eukaryotic translation initiation factor 4E family member 24.33E-07 2.09675 6.04E-07 2.03222 0.698003 -1.02036 0.334859 -1.05276

Tgfb1 transforming growth factor, beta 18.99E-05 2.21382 3.34E-05 2.49137 0.161291 -1.18494 0.651495 -1.05293

Pftk1 PFTAIRE protein kinase 18.04E-07 9.44027 9.10E-07 9.10593 0.926598 -1.01577 0.761449 -1.05307

Fkbp5 FK506 binding protein 5 4.25E-07 -9.03385 1.04E-07 -13.9706 0.032322 1.46846 0.736541 -1.05313

Ltbp4 latent transforming growth factor beta binding protein 48.91E-06 -2.41516 4.03E-06 -2.66434 0.618071 1.0471 0.57294 -1.05355

Hmgn3 high mobility group nucleosomal binding domain 38.17E-06 -1.83986 2.26E-06 -2.06055 0.345921 1.06263 0.411581 -1.05395

Vangl1 vang-like 1 (van gogh, Drosophila)2.55E-07 2.4075 9.53E-08 2.70893 0.015313 -1.18598 0.371247 -1.05401

RGD1565033similar to hypothetical protein LOC284018 isoform b7.41E-06 -2.66792 5.15E-06 -2.80164 0.969857 -1.00376 0.599647 -1.05407

Gngt2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 0.0006698 2.0953 0.003668 1.74774 0.378699 1.13696 0.710377 -1.05444

RGD1561963similar to Dedicator of cytokinesis protein 10 (Protein zizimin 3)5.23E-05 2.02181 0.000321 1.71955 0.262047 1.11502 0.572726 -1.05449

Crlf1 cytokine receptor-like factor 19.98E-08 -7.47923 4.57E-08 -9.23112 0.200998 1.17016 0.649058 -1.05476

Acsl4 acyl-CoA synthetase long-chain family member 41.95E-05 2.06493 1.08E-05 2.19424 0.197054 -1.12094 0.528765 -1.05487

Ccdc3 coiled-coil domain containing 31.72E-05 3.16178 0.000214 2.24189 0.051263 1.33635 0.681675 -1.05535

Homer1 homer homolog 1 (Drosophila)0.001378 2.10005 0.002137 1.99336 0.988902 -1.00223 0.734823 -1.05587

Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain)4.02E-05 2.01281 3.93E-05 2.01724 0.528392 -1.05862 0.544041 -1.05629

Tspan13 tetraspanin 13 1.67E-07 9.03709 2.24E-07 8.32972 0.844953 1.02698 0.687969 -1.05642

Fam117b family with sequence similarity 117, member B4.66E-07 -3.29906 1.73E-07 -3.8814 0.223563 1.11361 0.519456 -1.05649

Ino80c INO80 complex subunit C7.31E-07 -2.20697 1.02E-06 -2.13374 0.15977 -1.09292 0.36456 -1.05666

LOC360919 similar to alpha-fetoprotein1.68E-06 3.00648 1.73E-06 2.99374 0.581369 -1.05238 0.551026 -1.05686

LOC503192 zinc finger protein ZFP 6.51E-06 -2.1672 8.70E-06 -2.10429 0.287675 -1.08874 0.47797 -1.05713

of 148Diabetes

Aldh7a1 aldehyde dehydrogenase 7 family, member A14.00E-07 2.20813 1.66E-06 1.93166 0.179435 1.08119 0.324484 -1.05728

Arhgap22 Rho GTPase activating protein 223.62E-05 -2.47954 8.15E-05 -2.24946 0.202158 -1.16611 0.624532 -1.05791

RGD1309492similar to mKIAA1737 protein7.07E-05 -2.30968 6.46E-05 -2.33454 0.693501 -1.04681 0.627642 -1.05807

Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 94.13E-06 -1.95791 2.32E-06 -2.06428 0.952321 -1.00377 0.380353 -1.05831

Pllp plasma membrane proteolipid (plasmolipin)3.02E-06 -3.96483 4.14E-06 -3.74948 0.375757 -1.11923 0.648925 -1.05844

Tchh Trichohyalin 2.10E-07 8.6532 1.24E-07 10.0749 0.154659 -1.23266 0.679418 -1.05872

Tpm3 tropomyosin 3, gamma 1.95E-08 3.06694 9.07E-09 3.43835 0.0098 -1.18759 0.291612 -1.05931

Zadh2 zinc binding alcohol dehydrogenase, domain containing 20.0001505 -2.59847 8.32E-05 -2.82788 0.854902 1.02723 0.695385 -1.05944

LOC100361122SRY-box containing gene 90.0017457 2.19777 0.006382 1.87068 0.562529 1.10884 0.743959 -1.05954

LOC690492 similar to CD33 antigen0.0003177 2.42159 0.000308 2.43123 0.68454 -1.06391 0.703599 -1.05969

Ecop EGFR-coamplified and overexpressed protein0.0093936 2.31805 0.009401 2.31774 0.820775 -1.05964 0.820372 -1.05978

Pcdhga1 /// Pcdhga10 /// Pcdhga11 /// Pcdhga12 /// Pcdhga2 /// Pcdhga3 /// Pcdhga5 /// Pcdhga7 /// Pcdhga8 /// Pcdhga9 /// Pcdhgb7 /// Pcdhgb8 /// Pcdhgc3protocadherin gamma subfamily A, 1 /// protocadherin gamma subfamily A, 10 /// protocad8.96E-06 2.01808 2.31E-05 1.85455 0.71865 1.02675 0.435089 -1.05983

Lmna lamin A 7.98E-09 3.43365 1.30E-08 3.18737 0.756573 1.01622 0.278303 -1.06007

Rpesp RPE-spondin 4.25E-06 -5.36413 0.000471 -2.38334 0.000467 -2.38597 0.713084 -1.06012

Gipc2 GIPC PDZ domain containing family, member 2 /// GIPC PDZ domain containing family, memb0.0001306 2.36304 7.53E-05 2.53481 0.334941 -1.1374 0.653091 -1.06033

Coq10a coenzyme Q10 homolog A (S. cerevisiae)2.27E-06 -1.91923 8.37E-07 -2.10176 0.587338 1.03144 0.305756 -1.06173

Mal mal, T-cell differentiation protein7.46E-09 -1.99172 3.53E-09 -2.13276 0.768819 1.00848 0.062885 -1.0618

Sorl1 sortilin-related receptor, LDLR class A repeats-containing2.35E-08 -4.30283 1.34E-08 -4.79625 0.496499 1.04967 0.403035 -1.06193

RGD1310686similar to chromosome 16 open reading frame 54.29E-07 -2.0998 1.62E-07 -2.31793 0.464203 1.0393 0.2637 -1.06214

Surf4 surfeit 4 1.43E-05 2.0259 2.43E-05 1.92808 0.885695 -1.0113 0.445668 -1.06261

Ifitm1 interferon induced transmembrane protein 10.0002168 -11.1902 0.000132 -13.4126 0.760392 1.12718 0.875353 -1.06337

Lama3 laminin, alpha 3 9.35E-06 8.13801 1.35E-05 7.35457 0.856314 1.04052 0.779505 -1.06344



Usp46 ubiquitin specific peptidase 460.000143 -2.1764 0.000313 -1.99993 0.238957 -1.15754 0.605905 -1.06368

RGD1310964similar to RIKEN cDNA 9430031J160.228712 -1.25424 0.000819 -2.47046 0.007572 1.85152 0.731061 -1.06382

Sardh sarcosine dehydrogenase0.415138 -1.34203 0.449814 1.31256 0.103883 -1.87397 0.86101 -1.06385

C7orf42 chromosome 7 open reading frame 420.0216793 -2.36413 0.009785 -2.772 0.756155 1.10212 0.842923 -1.06389

C7orf42 chromosome 7 open reading frame 420.0216793 -2.36413 0.009785 -2.772 0.756155 1.10212 0.842923 -1.06389

Dzip1l DAZ interacting protein 1-like1.83E-05 2.55526 6.47E-05 2.19926 0.421898 1.09209 0.568238 -1.06389

Gpt glutamic-pyruvate transaminase (alanine aminotransferase)2.21E-09 -4.22962 7.47E-10 -5.22237 0.017456 1.16047 0.248703 -1.06398

Gpc3 glypican 3 0.0006695 -2.24358 0.000335 -2.45463 0.860039 1.02778 0.688793 -1.0645

LOC689147 Hypothetical protein LOC6891470.0001904 -3.23464 0.005848 -1.96115 0.014344 -1.75685 0.736128 -1.06517

Actn1 actinin, alpha 1 2.98E-13 70.6093 3.92E-13 61.1928 0.135943 1.08308 0.224788 -1.06538

Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent)2.02E-05 -2.89884 6.47E-05 -2.47449 0.10098 -1.24821 0.610374 -1.06548

of 148 Diabetes

LOC678772 similar to O-acetyltransferase1.05E-05 -2.70232 1.60E-05 -2.55694 0.279057 -1.12611 0.552176 -1.06553

Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, 4.31E-07 4.58407 4.07E-07 4.63599 0.48789 -1.07775 0.553919 -1.06568

Cdc27 cell division cycle 27 homolog (S. cerevisiae)0.0001033 1.69249 5.42E-06 2.19973 0.002312 -1.38555 0.414053 -1.06605

Ppp1r26 protein phosphatase 1, regulatory subunit 262.25E-05 -2.57516 1.15E-05 -2.81882 0.813444 1.02668 0.569158 -1.06618

Runx1 runt-related transcription factor 11.90E-05 2.86133 7.88E-05 2.37059 0.321555 1.13182 0.598129 -1.06643

Bcl2l14 Bcl2-like 14 (apoptosis facilitator)1.92E-05 -2.62121 0.000575 -1.80667 0.003634 -1.54768 0.564769 -1.06674

Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide2.54E-05 10.3594 2.57E-05 10.3247 0.826811 -1.06324 0.817535 -1.06681

Tm9sf3 transmembrane 9 superfamily member 38.86E-06 -1.87694 3.21E-06 -2.0557 0.692892 1.02627 0.334406 -1.0672

Il6ra interleukin 6 receptor, alpha1.35E-05 -2.70711 5.04E-05 -2.29631 0.062064 -1.2583 0.555674 -1.06736

Agps alkylglycerone phosphate synthase4.52E-06 2.58041 1.54E-05 2.23622 0.398297 1.08088 0.474638 -1.06757

Zmym2 zinc finger, MYM-type 2 6.20E-06 -1.89684 6.67E-07 -2.35781 0.038691 1.16374 0.314264 -1.06813

Csf3r colony stimulating factor 3 receptor (granulocyte)3.29E-06 5.32715 5.14E-06 4.83994 0.84406 1.03042 0.666697 -1.06816

LOC681740 similar to jumonji protein0.0002187 -1.95447 5.96E-05 -2.2422 0.518345 1.0738 0.547853 -1.06837

Sod2 superoxide dismutase 2, mitochondrial1.32E-07 -2.91603 9.44E-07 -2.29497 0.00117 -1.35767 0.317771 -1.06851

Rbp2 retinol binding protein 2, cellular1.93E-06 3.28797 6.87E-07 3.90263 0.041129 -1.26851 0.516102 -1.06872

Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) /// Fc fragment of IgG, low affin0.0020012 5.89877 0.002553 5.48933 0.98927 1.00549 0.870336 -1.06873

Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypepti7.50E-06 2.23131 9.63E-06 2.17308 0.624596 -1.04098 0.423288 -1.06887

Krt14 keratin 14 2.53E-07 2.40767 4.80E-07 2.24547 0.959911 1.00288 0.262502 -1.06916

C1QTNF1 C1q and tumor necrosis factor related protein 12.33E-05 -1.83952 3.85E-06 -2.17287 0.191654 1.10478 0.366296 -1.0692

Slc14a1 solute carrier family 14 (urea transporter), member 10.0009598 -6.20384 0.000996 -6.13802 0.834202 -1.08089 0.856621 -1.06942

Clip4 CAP-GLY domain containing linker protein family, member 40.110206 -1.31529 0.000571 -2.31573 0.011415 1.64611 0.671034 -1.06957

Asgr1 asialoglycoprotein receptor 13.62E-05 -2.28467 0.000742 -1.70195 0.007018 -1.43606 0.52152 -1.06978

Dci dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase)6.11E-05 -2.83045 3.50E-05 -3.07827 0.907422 1.01649 0.633348 -1.06991

Nudt6 nudix (nucleoside diphosphate linked moiety X)-type motif 68.48E-08 -3.24229 4.76E-08 -3.54706 0.742712 1.02219 0.323843 -1.07025

Cxxc5 CXXC finger 5 1.31E-06 -2.21035 7.44E-07 -2.34857 0.907234 -1.00748 0.303781 -1.07048

Klf3 Kruppel-like factor 3 (basic)3.67E-05 -1.86716 1.20E-05 -2.06915 0.661896 1.03519 0.397264 -1.07051

Rab15 RAB15, member RAS oncogene family0.0013913 -1.95106 0.000432 -2.23271 0.6464 1.06892 0.638858 -1.07058

Ypel3 yippee-like 3 (Drosophila)0.0001679 -2.01516 5.88E-05 -2.25629 0.683648 1.04584 0.538089 -1.07058

Icos Inducible T-cell co-stimulator1.48E-05 2.42419 2.63E-05 2.26763 0.987005 -1.0016 0.494168 -1.07075

Ap1s2 adaptor-related protein complex 1, sigma 2 subunit0.0001541 2.61175 0.000844 2.10223 0.330543 1.16024 0.646345 -1.07078

Asf1a ASF1 anti-silencing function 1 homolog A (S. cerevisiae)6.67E-06 -3.03765 1.57E-05 -2.69105 0.115762 -1.20896 0.541468 -1.07102

Cdc42ep5 CDC42 effector protein (Rho GTPase binding) 51.19E-05 1.93232 3.11E-06 2.19749 0.021007 -1.21816 0.347576 -1.07116

Znf23 zinc finger protein 23 (KOX 16)6.25E-07 -2.4148 4.38E-07 -2.51715 0.67477 -1.02762 0.303765 -1.07117

Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 /// cytochrome P450, family 2, su6.64E-05 -2.96382 0.000478 -2.25802 0.045147 -1.40707 0.642211 -1.07199

Glb1l2 galactosidase, beta 1-like 20.0013742 -2.02268 0.000164 -2.65169 0.208645 1.22279 0.648529 -1.07212

of 148Diabetes

Fam158a family with sequence similarity 158, member A7.93E-07 -3.59357 8.18E-07 -3.57535 0.447382 -1.07767 0.477772 -1.07221

Hbs1l Hbs1-like (S. cerevisiae) 7.39E-08 2.11025 1.30E-07 2.00364 0.657813 -1.0187 0.118831 -1.0729

Mov10 Moloney leukemia virus 101.71E-06 2.03986 2.70E-06 1.95692 0.626469 -1.02961 0.255096 -1.07325

Znf593 zinc finger protein 593 3.31E-05 2.14699 1.54E-06 3.16445 0.001064 -1.58207 0.463096 -1.07339

Eraf erythroid associated factor0.0024551 -1.94384 0.000426 -2.411 0.372728 1.1553 0.654698 -1.0736

Ankrd44 ankyrin repeat domain 442.25E-06 -1.79434 5.06E-07 -2.03391 0.302174 1.05555 0.184117 -1.07386

Cxcl16 chemokine (C-X-C motif) ligand 163.96E-06 3.22134 3.43E-06 3.29379 0.401835 -1.09808 0.518801 -1.07393

Mpzl1 myelin protein zero-like 18.21E-08 6.06253 9.61E-08 5.84866 0.727224 -1.03624 0.488634 -1.07413

Klhl23 kelch-like 23 (Drosophila)0.0001999 -2.81611 0.000293 -2.66047 0.447287 -1.13704 0.667867 -1.0742

LOC100909928uncharacterized LOC1009099280.0125331 2.69195 0.031814 2.23069 0.716736 1.1232 0.822192 -1.07441

Gbp2 guanylate binding protein 22.24E-05 5.91648 1.35E-06 13.2391 0.002519 -2.40457 0.731846 -1.07459

ALCAM activated leukocyte cell adhesion molecule0.0004681 2.62247 0.000689 2.48035 0.925228 -1.01659 0.682191 -1.07484

Tfrc transferrin receptor 5.51E-05 3.25937 4.20E-05 3.41057 0.462379 -1.12495 0.647754 -1.07508

Plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 13.38E-06 -5.91717 9.31E-06 -4.73022 0.095431 -1.34629 0.652993 -1.07623

Frmpd1 FERM and PDZ domain containing 12.41E-07 -3.19978 1.07E-06 -2.6096 0.005178 -1.32044 0.339891 -1.07689

Sdf2l1 stromal cell-derived factor 2-like 18.18E-05 2.2647 3.52E-05 2.50849 0.152546 -1.19293 0.524935 -1.07699

Ctsh cathepsin H 1.25E-05 2.59874 7.64E-05 2.10437 0.211169 1.1465 0.481238 -1.07713

Casp1 caspase 1 0.0066491 -1.84763 0.133005 -1.32648 0.043051 -1.50048 0.671271 -1.07725

Ahcyl2 adenosylhomocysteinase-like 25.99E-07 2.98163 9.16E-07 2.81218 0.840284 -1.01618 0.361862 -1.07741

Sfxn3 sideroflexin 3 0.0001584 -1.93954 1.78E-05 -2.45831 0.14116 1.17621 0.473741 -1.07759

LOC306766 hypothetical LOC3067668.96E-06 -1.99925 2.89E-06 -2.23673 0.606417 1.03813 0.314877 -1.0777

Capn13 calpain 13 0.945639 1.01098 0.031336 1.49856 0.016607 -1.59762 0.642247 -1.07781

Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a5.30E-07 6.13217 7.56E-07 5.65159 0.963337 1.00599 0.564887 -1.07857

Emilin2 elastin microfibril interfacer 20.00139 2.20477 0.004058 1.93163 0.741423 1.05813 0.659116 -1.0787

Rbpms2 RNA binding protein with multiple splicing 20.0125499 2.3876 0.034291 1.99811 0.716779 1.10752 0.786876 -1.07892

RGD1304587similar to RIKEN cDNA 2310033P093.11E-06 -2.55053 1.06E-05 -2.21496 0.029158 -1.24276 0.379225 -1.07925

Plekhn1 pleckstrin homology domain containing, family N member 13.50E-07 -2.36325 9.81E-08 -2.75232 0.215933 1.07905 0.214625 -1.07931

Cugbp1 CUG triplet repeat, RNA binding protein 15.54E-06 3.70827 3.62E-06 4.00245 0.252436 -1.16498 0.554533 -1.07935

Acaa2 Acetyl-Coenzyme A acyltransferase 20.0110733 -2.10975 0.456931 -1.19427 0.021765 -1.90672 0.745395 -1.07935

Dos downstream of Stk11 1.38E-05 -2.13402 2.09E-06 -2.65013 0.121521 1.15049 0.372735 -1.07941

Zyx zyxin 0.0001468 2.73943 7.73E-05 3.01732 0.280306 -1.18907 0.622575 -1.07956

C1ql3 Complement component 1, q subcomponent-like 30.0001696 -2.27722 0.004904 -1.61553 0.009733 -1.52307 0.551921 -1.08051

Rhov ras homolog gene family, member V0.0002123 2.255 0.000326 2.14463 0.835354 -1.02772 0.559531 -1.08061

Zfp423 zinc finger protein 423 5.80E-07 -3.45662 1.17E-06 -3.10381 0.066286 -1.20353 0.399341 -1.08069

Chd6 chromodomain helicase DNA binding protein 62.32E-05 -2.09086 1.54E-05 -2.18084 0.684008 -1.03631 0.384025 -1.08091

of 148 Diabetes

Ttc39a tetratricopeptide repeat domain 39A0.981653 1.00573 0.018065 -2.04215 0.028764 1.89881 0.752984 -1.08166

Ms4a8a membrane-spanning 4-domains, subfamily A, member 8A0.0004008 13.8409 5.63E-05 32.8594 0.070532 -2.5681 0.866429 -1.08172

Kif5b kinesin family member 5B3.90E-06 2.04183 8.21E-07 2.39976 0.005773 -1.27145 0.256525 -1.08181


Atp11a ATPase, class VI, type 11A1.90E-08 3.30008 2.15E-08 3.23855 0.297669 -1.06221 0.182088 -1.08239

Nlk nemo like kinase 4.82E-05 -2.0312 1.32E-05 -2.33113 0.532859 1.06027 0.403572 -1.08242

Gsta5 glutathione S-transferase Yc2 subunit1.53E-05 -3.56504 4.27E-05 -3.01662 0.111156 -1.27931 0.580261 -1.08251


Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial8.70E-06 -2.14507 1.92E-05 -1.98537 0.074394 -1.17006 0.328476 -1.08294

Gls glutaminase 0.997084 1.00056 0.001568 -1.99802 0.00321 1.84562 0.603242 -1.08317

Ezh1 enhancer of zeste homolog 1 (Drosophila)2.27E-05 -2.25826 2.28E-05 -2.25756 0.413549 -1.08357 0.415282 -1.08323

Iqub IQ motif and ubiquitin domain containing0.127424 -1.3118 0.000184 -2.83224 0.002555 1.9917 0.626827 -1.08402

Obsl1 obscurin-like 1 0.0002704 -3.16211 0.000746 -2.68159 0.224676 -1.27869 0.676042 -1.08438

Dsg2 desmoglein 2 0.0001823 1.99282 0.00014 2.04708 0.336445 -1.11403 0.464471 -1.0845

Afg3l1 AFG3(ATPase family gene 3)-like 1 (S. cerevisiae)0.0272964 -1.88453 0.017318 -2.02032 0.961279 -1.01185 0.738286 -1.08476

Dyrk3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 34.10E-05 2.23193 0.000199 1.89909 0.445968 1.08301 0.435044 -1.08518

S100a3 S100 calcium binding protein A30.0002044 1.97818 0.00015 2.04133 0.317795 -1.11983 0.463654 -1.08519

Sh3bgr SH3 domain binding glutamic acid-rich protein7.40E-06 -4.08298 1.28E-05 -3.69243 0.223258 -1.20004 0.569978 -1.08525

Map4k4 mitogen-activated protein kinase kinase kinase kinase 47.06E-06 2.17652 2.32E-05 1.93903 0.672478 1.03385 0.310002 -1.08573

Spata7 spermatogenesis associated 71.88E-05 -2.00542 1.66E-05 -2.02887 0.38827 -1.07323 0.319079 -1.08578

Heatr6 HEAT repeat containing 60.0002444 -1.78207 2.87E-05 -2.18783 0.222016 1.13011 0.396125 -1.08634

Ccdc92 coiled-coil domain containing 920.0001121 -2.37667 6.91E-05 -2.52764 0.867622 -1.0215 0.521453 -1.08639

Nudt4 nudix (nucleoside diphosphate linked moiety X)-type motif 41.37E-07 -1.91743 5.78E-08 -2.0685 0.849555 -1.00747 0.05975 -1.08685

St6galnac2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-24.84E-08 3.43721 2.48E-08 3.83388 0.015651 -1.21275 0.221392 -1.08728

S1pr2 sphingosine-1-phosphate receptor 21.96E-05 2.34772 0.000229 1.82808 0.119574 1.18113 0.406494 -1.0873

Slc2a13 solute carrier family 2 (facilitated glucose transporter), member 138.31E-06 -2.62327 3.30E-06 -2.97585 0.671141 1.04329 0.409319 -1.08734

Ppp4r1 protein phosphatase 4, regulatory subunit 17.54E-09 2.06273 8.18E-09 2.04748 0.030911 -1.07941 0.020882 -1.08745

Znrf2 zinc and ring finger 2 3.13E-06 -2.7874 5.79E-07 -3.58858 0.09699 1.18381 0.377376 -1.08753

Krt8 keratin 8 0.0031817 -2.23649 0.051383 1.55769 0.000127 -3.78891 0.676056 -1.08759

LOC100362894Hypothetical protein LOC1003628941.74E-06 -17.0277 1.96E-06 -16.3129 0.595832 -1.1354 0.724013 -1.08774

Fxyd4 FXYD domain-containing ion transport regulator 40.0697755 -1.8182 0.022852 -2.23195 0.683938 1.12825 0.775341 -1.08802

Fndc1 fibronectin type III domain containing 10.0002714 2.86392 0.00037 2.7312 0.834039 -1.03767 0.634438 -1.0881

Prss8 protease, serine, 8 0.0022522 -1.99657 0.000712 -2.30169 0.722638 1.05932 0.604131 -1.08826

Kidins220 kinase D-interacting substrate 2201.03E-05 -1.81585 2.20E-06 -2.08007 0.427885 1.05246 0.203809 -1.08841

Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 36.18E-07 5.31065 2.06E-06 4.16691 0.219172 1.17089 0.494117 -1.08847

of 148Diabetes

Tgm2 transglutaminase 2, C polypeptide0.0971868 -1.47406 0.061601 1.56642 0.002107 -2.51372 0.691754 -1.08866

Lcn2 lipocalin 2 0.75637 -1.6357 0.734758 1.71204 0.487561 -3.05006 0.956924 -1.08916

Rps6ka5 ribosomal protein S6 kinase, polypeptide 50.0404651 -2.04407 0.026485 -2.21395 0.984887 -1.00574 0.77758 -1.08932

Crk V-crk sarcoma virus CT10 oncogene homolog (avian)0.0003568 -1.78805 5.91E-05 -2.12505 0.402878 1.09069 0.407835 -1.08965

LOC503192 zinc finger protein ZFP 3.27E-06 -2.08018 1.51E-05 -1.81652 0.008926 -1.24789 0.219689 -1.08972

Afap1l2 actin filament associated protein 1-like 21.31E-08 16.6741 7.36E-09 20.6513 0.0392 -1.34984 0.500053 -1.08987

Twf1 twinfilin, actin-binding protein, homolog 1 (Drosophila)1.23E-08 2.01999 4.88E-08 1.80443 0.402414 1.02706 0.02138 -1.08997

Igsf8 immunoglobulin superfamily, member 85.73E-05 2.12963 0.000104 2.00422 0.80134 -1.02586 0.405269 -1.09005

RGD1311946similar to RIKEN cDNA 1810055G027.10E-06 3.44487 1.30E-05 3.12942 0.937641 1.0098 0.495259 -1.09012

Xpc xeroderma pigmentosum, complementation group C7.45E-06 -2.96256 2.69E-06 -3.46724 0.528072 1.07293 0.439065 -1.0908

Lrtomt leucine rich transmembrane and 0-methyltransferase domain containing1.38E-05 -3.49261 0.000907 -1.98068 0.001192 -1.92365 0.532778 -1.09091

Map2k6 mitogen-activated protein kinase kinase 65.61E-05 -4.10748 2.35E-05 -4.91909 0.62429 1.09762 0.646395 -1.09108

Cfl1 cofilin 1, non-muscle 8.25E-09 5.19956 1.51E-08 4.60542 0.627443 1.03455 0.230458 -1.0913

Urod uroporphyrinogen decarboxylase2.07E-06 -2.16135 1.05E-06 -2.3214 0.806449 -1.01633 0.207799 -1.09159

Ddit4 DNA-damage-inducible transcript 40.0143356 2.64123 0.055381 2.01088 0.569285 1.20325 0.785767 -1.0916

Larp1b La ribonucleoprotein domain family, member 1B2.05E-06 -2.04332 5.60E-06 -1.86986 0.01737 -1.19355 0.17452 -1.09222

Rnf149 ring finger protein 149 3.53E-06 2.04277 1.99E-05 1.76252 0.377867 1.06114 0.202607 -1.09223

Zmym3 zinc finger, MYM-type 3 2.48E-07 2.1688 7.46E-08 2.46704 0.002136 -1.24245 0.108017 -1.09225

Nadkd1 NAD kinase domain containing 10.0011925 -2.86598 0.007877 -2.12903 0.110478 -1.4704 0.691898 -1.0923

Ccl6 chemokine (C-C motif) ligand 60.0044465 2.73252 0.002485 3.04555 0.464957 -1.21772 0.739114 -1.09256

Gas6 growth arrest specific 6 1.15E-07 -6.02604 6.84E-08 -6.81232 0.748072 1.03466 0.41265 -1.09261

Fam49b family with sequence similarity 49, member B7.25E-06 2.20893 7.02E-06 2.21647 0.269804 -1.09636 0.286597 -1.09263

Mdh1 malate dehydrogenase 1, NAD (soluble)0.0008571 -3.71101 0.001361 -3.37883 0.492917 -1.20005 0.736083 -1.09263

Cdk105 CDK105 protein 4.02E-05 -6.80031 2.51E-05 -7.73267 0.870768 1.0406 0.717852 -1.09274

LOC498972 similar to copine II 0.0018042 2.02074 0.016999 1.58615 0.347197 1.16582 0.579429 -1.09279

Jazf1 JAZF zinc finger 1 4.44E-06 -2.28328 1.39E-05 -2.03217 0.026641 -1.22788 0.27485 -1.09284

Rb1 retinoblastoma 1 1.21E-07 -2.12253 6.62E-08 -2.25371 0.523109 -1.02928 0.073922 -1.09289

Krt23 keratin 23 (histone deacetylase inducible)0.0031401 8.36838 0.003391 8.1328 0.908609 -1.06228 0.865828 -1.09306

Wee1 wee 1 homolog (S. pombe)0.0027877 -1.56117 5.77E-05 -2.23882 0.032068 1.31174 0.419384 -1.09325

Trpm4 transient receptor potential cation channel, subfamily M, member 44.34E-05 2.00609 0.000329 1.68248 0.347638 1.09061 0.335023 -1.09328


Lmo4 LIM domain only 4 8.83E-06 -5.81095 4.64E-06 -6.8033 0.710771 1.07035 0.625864 -1.09382

Atrx Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)0.0049519 1.80677 0.000322 2.5224 0.025074 -1.52752 0.575347 -1.09414

Ppp1r3c protein phosphatase 1, regulatory (inhibitor) subunit 3C1.64E-07 -8.93917 4.14E-07 -6.9875 0.032952 -1.40018 0.509567 -1.09449

Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide7.81E-06 2.46156 6.29E-06 2.52734 0.224342 -1.12447 0.337207 -1.0952

of 148 Diabetes

Trib3 tribbles homolog 3 (Drosophila)0.0029418 2.54053 0.031394 1.77952 0.265725 1.30315 0.690909 -1.09554

Laptm5 lysosomal protein transmembrane 50.000242 4.05955 0.000509 3.50049 0.805858 1.05847 0.693706 -1.09564

Nat8b N-acetyltransferase 8B0.0072292 -1.75279 0.001693 -2.06727 0.651734 1.07634 0.576109 -1.09577

Sprr1al small proline-rich protein 1A-like0.0002682 2.54872 0.000949 2.16164 0.643322 1.07569 0.561872 -1.09611

Tpi1 triosephosphate isomerase 11.36E-05 3.43523 1.26E-05 3.47692 0.452219 -1.10944 0.504735 -1.09613

Arnt2 aryl hydrocarbon receptor nuclear translocator 22.30E-08 -5.96878 1.78E-08 -6.33569 0.708556 -1.03271 0.301076 -1.09619

Depdc7 DEP domain containing 70.0003003 3.37374 0.000733 2.88985 0.761826 1.06488 0.658623 -1.09631

DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)5.76E-06 3.03949 3.04E-06 3.352 0.109588 -1.20921 0.408316 -1.09648

Man2a1 mannosidase, alpha, class 2A, member 10.0006262 1.67255 3.12E-05 2.21292 0.004341 -1.45176 0.356199 -1.09726

Nlk /// RGD1561440nemo like kinase /// similar to nemo like kinase7.16E-06 -2.10681 3.63E-06 -2.26035 0.764815 -1.0228 0.237993 -1.09734

Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 41.59E-07 8.24821 2.29E-07 7.48798 0.97709 1.00373 0.480047 -1.09744

Calu calumenin 2.54E-08 3.98155 7.74E-08 3.31625 0.20473 1.09397 0.190544 -1.09749

Pgrmc2 progesterone receptor membrane component 22.21E-07 -2.57852 1.46E-07 -2.71469 0.498629 -1.04254 0.15181 -1.09759

Slc12a7 solute carrier family 12 (potassium/chloride transporters), member 71.18E-05 2.1335 1.72E-05 2.05432 0.499916 -1.05753 0.270318 -1.09829


Sbno2 strawberry notch homolog 2 (Drosophila)4.82E-05 2.14779 7.10E-05 2.06272 0.592588 -1.05547 0.358364 -1.099


Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like)2.26E-05 -2.08087 4.58E-06 -2.48064 0.360391 1.08456 0.291226 -1.09917

Phf7 PHD finger protein 7 7.28E-07 -3.29213 1.82E-06 -2.87848 0.02894 -1.25756 0.3032 -1.09956

Capn5 calpain 5 1.53E-05 -2.08614 1.64E-05 -2.0717 0.236511 -1.10726 0.267238 -1.0996

Accn4 amiloride-sensitive cation channel 4, pituitary4.93E-07 -9.36325 1.89E-07 -12.5723 0.230751 1.22102 0.554274 -1.09967

Cps1 carbamoyl-phosphate synthetase 12.41E-08 -9.59349 3.22E-07 -5.07169 0.000121 -2.08023 0.394903 -1.09974

Cds1 CDP-diacylglycerol synthase 14.77E-08 -2.12699 2.92E-08 -2.23293 0.261292 -1.04763 0.038642 -1.09981

Sec24d SEC24 family, member D (S. cerevisiae)2.13E-08 3.35811 1.80E-08 3.44481 0.062402 -1.12825 0.126234 -1.09986

Tceanc2 transcription elongation factor A (SII) N-terminal and central domain containing0.0001072 -2.08629 0.000366 -1.84855 0.070535 -1.243 0.381782 -1.10136

Mylip myosin regulatory light chain interacting protein1.45E-06 -5.13168 1.10E-06 -5.45023 0.784186 -1.03736 0.475719 -1.10176

Ezh1 enhancer of zeste homolog 1 (Drosophila)0.0002413 -2.01362 0.000171 -2.08772 0.59996 -1.06288 0.409872 -1.10199

Samd11 Sterile alpha motif domain containing 110.0001476 -2.4058 0.000243 -2.26174 0.257463 -1.17231 0.477185 -1.10211

Akt3 V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.0073353 2.31583 0.197816 1.39196 0.118755 1.50896 0.689331 -1.10256

Ddit4l /// LOC100364537DNA-damage-inducible transcript 4-like /// DNA-damage-inducible transcript 4-like prote0.0004893 -1.71263 5.56E-05 -2.09262 0.314284 1.10793 0.335143 -1.10285

Rab27a RAB27A, member RAS oncogene family0.0003981 -1.98158 0.000145 -2.21112 0.923996 1.01165 0.428719 -1.10299

Telo2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)3.57E-05 -2.14264 1.06E-05 -2.45753 0.685134 1.03972 0.320157 -1.10314

Usp46 ubiquitin specific peptidase 462.55E-05 -2.34975 7.56E-05 -2.08417 0.058826 -1.24394 0.350237 -1.10335

Ctsc cathepsin C 3.36E-06 2.88808 4.15E-06 2.80533 0.480404 -1.07187 0.324381 -1.10349

MSN moesin 3.68E-11 184.318 4.00E-11 174.461 0.696106 -1.04462 0.387031 -1.10365

of 148Diabetes

Sorl1 sortilin-related receptor, LDLR class A repeats-containing5.06E-08 -4.55398 3.28E-08 -4.96239 0.872763 -1.01297 0.240574 -1.10381

LOC100362119Zinc finger protein 383-like7.87E-06 -2.41981 5.55E-06 -2.52403 0.532644 -1.0587 0.289604 -1.1043

Spry1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)5.51E-06 -5.34786 6.76E-06 -5.11153 0.387903 -1.15546 0.547849 -1.1044

Sult1b1 sulfotransferase family, cytosolic, 1B, member 10.0131068 2.06849 0.171691 1.41019 0.250493 1.32798 0.675555 -1.10455

Farp1 FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)6.38E-05 5.29919 0.000118 4.61275 0.862661 1.04004 0.662882 -1.10458

C1qa complement component 1, q subcomponent, A chain0.0001269 4.08168 0.000332 3.39242 0.687213 1.0891 0.639084 -1.10474

Ralgps2 Ral GEF with PH domain and SH3 binding motif 22.79E-06 -2.62323 1.04E-06 -2.99372 0.711912 1.03234 0.262438 -1.10548

Emx2 empty spiracles homeobox 26.03E-07 -3.49065 3.85E-07 -3.76087 0.778273 -1.02605 0.28899 -1.10548

RGD1304644similar to RIKEN cDNA 2310046K010.0017525 -1.60037 0.596534 -1.05795 0.001009 -1.67279 0.353803 -1.10582

Syt8 synaptotagmin VIII 7.44E-07 -3.65469 5.84E-07 -3.80868 0.545196 -1.06123 0.315639 -1.10594

Map4k3 mitogen-activated protein kinase kinase kinase kinase 31.30E-06 -2.0149 5.17E-07 -2.20353 0.842435 -1.0113 0.102838 -1.10597

Atp5s ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)5.30E-05 -2.50303 4.57E-05 -2.55189 0.508197 -1.08503 0.416586 -1.1062

Cgn Cingulin 1.97E-08 -3.82605 1.33E-08 -4.0968 0.607141 -1.03328 0.137011 -1.1064

Fam113b family with sequence similarity 113, member B7.92E-05 -2.56939 8.89E-05 -2.53031 0.38993 -1.12361 0.452625 -1.10652

Fn3krp fructosamine-3-kinase-related protein2.30E-06 -3.25959 1.88E-06 -3.36434 0.502983 -1.0722 0.337788 -1.10666

Wdr31 WD repeat domain 31 1.85E-05 -2.32239 5.04E-05 -2.0837 0.055281 -1.23348 0.310332 -1.1067

Gpc2 glypican 2 0.022574 1.37387 0.012204 -1.43792 0.00089 1.78419 0.392595 -1.10723

Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.000118 -2.06895 5.16E-05 -2.26442 0.91366 -1.01177 0.35795 -1.10736

Casp12 caspase 12 0.285595 1.75887 0.129599 2.30188 0.473395 -1.44957 0.841083 -1.10762

Myocd myocardin 0.0037596 2.03474 0.000679 2.56827 0.093422 -1.39812 0.577276 -1.10768

Sesn1 sestrin 1 0.0080123 -2.22228 0.001221 -3.04067 0.381262 1.23498 0.664683 -1.10793

Bcl11b B-cell CLL/lymphoma 11B (zinc finger protein)0.0013982 2.27695 0.055563 1.47059 0.088139 1.39726 0.567736 -1.10812

Ankrd6 ankyrin repeat domain 67.94E-06 4.81943 1.77E-05 4.10269 0.719806 1.05963 0.526918 -1.10859

Sel1l sel-1 suppressor of lin-12-like (C. elegans)7.94E-06 2.24927 6.53E-06 2.29782 0.159717 -1.13261 0.234986 -1.10868

LOC688749 Similar to Tubby-related protein 3 (Tubby-like protein 3)5.61E-06 2.18466 1.02E-05 2.05805 0.571788 -1.04455 0.199958 -1.10882

LOC100366121rCG29408-like 3.74E-06 -2.76744 2.38E-06 -2.94566 0.665873 -1.04176 0.290409 -1.10885

Csf2ra Granulocyte-macrophage colony stimulating receptor alpha7.71E-05 -2.24574 6.02E-05 -2.31107 0.514316 -1.07759 0.372732 -1.10894

Sfrs18 splicing factor, arginine/serine-rich 180.001091 -2.00674 0.000339 -2.3042 0.812681 1.03491 0.479476 -1.1095

Syde2-ps1 Synapse defective 1, Rho GTPase, homolog 2 (C. elegans), pseudogene 14.67E-05 -2.966 7.41E-05 -2.77062 0.244951 -1.18782 0.470168 -1.10957

Dgka diacylglycerol kinase, alpha1.78E-05 2.16622 0.000776 1.56575 0.032507 1.24684 0.258132 -1.10961

Ifngr2 interferon gamma receptor 22.05E-08 -3.72828 2.82E-08 -3.53896 0.031954 -1.16929 0.122048 -1.10991

Mx1 myxovirus (influenza virus) resistance 10.736973 1.32253 0.198333 3.08757 0.270175 -2.5913 0.899936 -1.10996

Hspa12a heat shock 70kDa protein 12A1.04E-07 -3.26844 1.75E-08 -4.41858 0.018308 1.21788 0.156316 -1.11004

Tesk2 testis-specific kinase 2 4.33E-06 -2.0546 6.57E-05 -1.64448 0.001096 -1.3869 0.151408 -1.11006


of 148 Diabetes

Pgk1 phosphoglycerate kinase 15.42E-07 2.23227 1.15E-06 2.07252 0.589671 -1.03193 0.095583 -1.11148

Bcr breakpoint cluster region1.03E-05 2.20794 0.000592 1.56038 0.017869 1.27305 0.229643 -1.1115

Dapl1 death associated protein-like 12.49E-06 -18.2357 1.34E-06 -23.2768 0.590324 1.14835 0.679474 -1.11154

Polb polymerase (DNA directed), beta5.50E-05 -1.8263 1.49E-05 -2.05554 0.881442 1.01204 0.208811 -1.11213

Lap3 leucine aminopeptidase 32.60E-05 2.34039 7.14E-05 2.09399 0.961583 1.00493 0.313936 -1.11219

Prdx4 peroxiredoxin 4 7.30E-07 2.90448 6.02E-07 2.98401 0.122194 -1.14276 0.205383 -1.1123

Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.0050028 2.08023 0.005127 2.0734 0.602764 -1.1091 0.591503 -1.11275

RGD1566215Similar to Coatomer gamma-2 subunit (Gamma-2 coat protein) (Gamma-2 COP)0.326546 1.3052 0.209603 -1.41586 0.081767 1.66066 0.686004 -1.1128

Atat1 alpha tubulin acetyltransferase 15.41E-06 -1.9686 6.79E-07 -2.43314 0.138631 1.1106 0.132065 -1.11288

RGD1565033similar to hypothetical protein LOC284018 isoform b1.97E-05 -3.26454 1.46E-05 -3.42736 0.66862 -1.06065 0.440565 -1.11355

Dap death-associated protein1.46E-06 -3.51523 1.16E-06 -3.64801 0.494712 -1.07383 0.308384 -1.1144

Fut1 fucosyltransferase 1 5.68E-05 4.18261 0.000713 2.68192 0.107766 1.39927 0.574974 -1.11455

Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domai2.51E-05 -2.3266 4.58E-05 -2.17587 0.110333 -1.19197 0.299018 -1.11474

Dap Death-associated protein2.98E-05 -2.34511 0.00044 -1.78391 0.00536 -1.46575 0.312876 -1.11498

MGC94335 similar to hypothetical protein FLJ225550.0258704 -1.43262 0.729505 -1.0483 0.012639 -1.52396 0.432013 -1.11514

Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a2.97E-07 12.0719 1.72E-07 14.4815 0.107273 -1.33811 0.515437 -1.11546

Chn1 chimerin (chimaerin) 1 7.40E-06 -2.53526 1.29E-06 -3.22429 0.189328 1.13999 0.265275 -1.1156

PARVA parvin, alpha 2.43E-06 3.41351 3.46E-06 3.22817 0.619066 -1.05527 0.322774 -1.11585

Crip2 cysteine-rich protein 2 6.02E-06 2.5575 8.32E-06 2.45768 0.454039 -1.07312 0.253371 -1.1167

CTSC cathepsin C 1.27E-06 3.04014 2.59E-06 2.75368 0.894778 -1.01189 0.23639 -1.11715

Dync1i1 dynein cytoplasmic 1 intermediate chain 14.65E-11 -30.5626 4.02E-11 -32.5549 0.530802 -1.04883 0.166329 -1.11721


Bcl6 B-cell CLL/lymphoma 60.0037266 -1.50105 2.74E-05 -2.35675 0.009636 1.40454 0.299809 -1.11785

Lamb3 laminin, beta 3 7.36E-07 9.10392 1.54E-06 7.44089 0.588145 1.09451 0.506217 -1.11785

Mtm1 myotubularin 1 1.02E-05 -1.83152 3.62E-06 -2.00273 0.730466 -1.02237 0.109875 -1.11794


Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit1.62E-06 -2.4071 1.98E-06 -2.35224 0.092947 -1.14404 0.152684 -1.11797

Stx7 syntaxin 7 1.65E-07 -2.64163 7.85E-08 -2.91108 0.807617 -1.01473 0.090564 -1.11823

Fam104a family with sequence similarity 104, member A1.17E-05 -2.1057 1.75E-06 -2.60695 0.228873 1.10657 0.186631 -1.11881

Ddah2 dimethylarginine dimethylaminohydrolase 21.03E-05 -3.16342 1.58E-06 -4.37471 0.110857 1.23578 0.368836 -1.11905

Scarb1 scavenger receptor class B, member 10.0001251 3.68973 0.000162 3.51793 0.740697 -1.06702 0.568615 -1.11913

Mgst1 microsomal glutathione S-transferase 15.30E-05 2.21215 5.93E-05 2.18533 0.352396 -1.10592 0.300472 -1.1195

Fcho2 FCH domain only 2 0.186616 -1.4103 0.010272 -2.21301 0.194231 1.40112 0.64686 -1.11994

Ggta1 glycoprotein, alpha-galactosyltransferase 10.0019065 2.66148 0.001378 2.80893 0.460326 -1.18214 0.613399 -1.12009

Capn1 calpain 1 2.64E-06 -2.38881 1.35E-06 -2.58778 0.662092 -1.03442 0.165475 -1.12058

of 148Diabetes

Dusp6 dual specificity phosphatase 60.0655549 2.41615 0.113824 2.08407 0.936834 1.03441 0.789837 -1.12078

Col14a1 collagen, type XIV, alpha 17.67E-08 -17.4657 6.29E-08 -18.7916 0.797874 -1.0419 0.48229 -1.12099

Tgfbr1 transforming growth factor, beta receptor 15.50E-05 -1.80822 1.26E-05 -2.06507 0.814787 1.01868 0.17326 -1.1211

Tec tec protein tyrosine kinase4.16E-06 2.34144 6.88E-05 1.78774 0.080599 1.16732 0.175213 -1.12199

Gyg1 glycogenin 1 8.48E-06 -2.49261 3.70E-06 -2.77308 0.927775 -1.00858 0.242822 -1.12206

Ypel4 yippee-like 4 (Drosophila)6.54E-07 -7.92849 4.63E-07 -8.71661 0.893342 -1.02067 0.458082 -1.12212

Ostc oligosaccharyltransferase complex subunit6.13E-07 2.16856 1.36E-06 2.00903 0.498532 -1.03961 0.068572 -1.12216


St5 suppression of tumorigenicity 50.0012071 2.22238 0.016969 1.63305 0.27165 1.2126 0.499876 -1.12228


Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.0005656 -2.11864 0.000124 -2.56173 0.601493 1.07686 0.419696 -1.12284

LOC680770 similar to dachshund b [ 5.85E-05 -2.71464 5.99E-05 -2.70524 0.384626 -1.12702 0.397924 -1.12311

Tagln2 transgelin 2 9.68E-08 2.25747 2.36E-08 2.65016 0.000295 -1.31858 0.033881 -1.12319

Cyhr1 cysteine and histidine rich 10.0007868 -2.33796 0.00074 -2.35729 0.524363 -1.114 0.494115 -1.12321

Trim2 tripartite motif-containing 25.36E-08 -2.80838 2.34E-08 -3.14995 0.979294 -1.00143 0.061481 -1.12323

Rprd1a regulation of nuclear pre-mRNA domain containing 1A5.89E-05 2.67173 3.28E-05 2.90394 0.157085 -1.22136 0.38914 -1.1237

Sdc1 syndecan 1 1.79E-08 -2.11762 7.77E-09 -2.30263 0.359162 -1.03342 0.008682 -1.12371

Klf7 Kruppel-like factor 7 (ubiquitous)8.51E-06 5.69322 1.62E-05 4.92459 0.874488 1.02878 0.521448 -1.12373

Uba5 ubiquitin-like modifier activating enzyme 51.22E-06 2.07267 2.60E-06 1.93538 0.41522 -1.04969 0.071834 -1.12415

Prr12 proline rich 12 1.56E-05 -2.26982 1.51E-05 -2.27838 0.237333 -1.12032 0.223487 -1.12455

Epha7 Eph receptor A7 2.65E-06 3.22779 1.16E-05 2.6181 0.386545 1.0963 0.275869 -1.12458

Purg Purine-rich element binding protein G0.0219429 -1.55801 0.0018 -2.04659 0.349649 1.16801 0.473969 -1.12464

RGD1562344similar to Gm566 protein0.0020044 2.18257 0.005554 1.91949 0.953152 1.01057 0.515815 -1.12517

Cdo1 cysteine dioxygenase, type I9.60E-07 -8.38469 8.39E-07 -8.70553 0.627795 -1.08375 0.480774 -1.12522

LOC100364718myeloid/lymphoid or mixed-lineage leukemia 3-like0.0001125 -1.41652 2.25E-07 -2.22467 0.000153 1.39542 0.044756 -1.12549

RGD1563441similar to RIKEN cDNA A030009H041.04E-05 -2.91052 9.10E-06 -2.9679 0.393184 -1.10416 0.311514 -1.12593

Irf7 interferon regulatory factor 70.0109278 -2.33085 0.017924 -2.14276 0.452403 -1.22483 0.656289 -1.12599

LOC100909946uncharacterized LOC1009099464.75E-06 2.80282 2.41E-05 2.28917 0.406274 1.08721 0.248113 -1.12617

Slc47a1 solute carrier family 47, member 10.0074661 2.00862 0.067851 1.51304 0.427822 1.17811 0.559723 -1.12684

Homer3 homer homolog 3 (Drosophila)0.0004143 2.12069 0.000949 1.93688 0.829824 -1.0293 0.384851 -1.12698

Fam188a family with sequence similarity 188, member A2.63E-06 -1.78045 3.07E-07 -2.14375 0.217228 1.06836 0.041741 -1.127

Foxn3 forkhead box N3 1.52E-05 -1.71066 1.43E-06 -2.0842 0.218466 1.08063 0.072675 -1.12745

Kitlg KIT ligand 0.0081007 2.42422 0.004054 2.7396 0.366524 -1.27416 0.648184 -1.12747

RGD1562012RGD1562012 7.81E-06 -2.45282 1.72E-05 -2.24037 0.044971 -1.23445 0.213097 -1.12753

Lgals9 lectin, galactoside-binding, soluble, 90.496438 -1.22223 0.135103 1.59698 0.023176 -2.20086 0.681178 -1.12756

of 148 Diabetes

Slc39a13 solute carrier family 39 (zinc transporter), member 132.21E-06 2.2335 2.80E-06 2.17908 0.193007 -1.10026 0.111529 -1.12774

RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)5.23E-05 2.67317 0.020327 1.43866 0.00417 1.64748 0.367734 -1.12785

Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like0.0002844 2.43363 9.84E-05 2.82288 0.101806 -1.30828 0.431915 -1.12788

Tk1 thymidine kinase 1, soluble5.83E-05 1.95723 2.51E-06 2.79299 0.000611 -1.60967 0.20548 -1.128

Cpsf7 cleavage and polyadenylation specific factor 7, 59kDa4.62E-06 1.78255 7.47E-07 2.08317 0.000825 -1.31921 0.052601 -1.12884

LOC680039 hypothetical protein LOC6800392.01E-07 -2.09508 3.41E-08 -2.52945 0.177106 1.06944 0.028202 -1.12893

Gca grancalcin 2.33E-05 -2.78973 1.58E-05 -2.94954 0.590956 -1.06805 0.331635 -1.12923

Nat15 N-acetyltransferase 15 (GCN5-related, putative)3.47E-05 -2.07454 7.36E-05 -1.92921 0.059203 -1.21436 0.206146 -1.12929

Aig1 androgen-induced 1 1.64E-05 2.2727 5.71E-05 1.99669 0.936212 1.00744 0.210837 -1.12983

Pibf1 progesterone immunomodulatory binding factor 10.0011297 -1.76389 0.044614 -1.31403 0.006656 -1.51747 0.316607 -1.13046

Pecr peroxisomal trans-2-enoyl-CoA reductase3.95E-08 -6.82264 1.47E-08 -8.82562 0.196373 1.14428 0.235567 -1.13048

Nrcam neuronal cell adhesion molecule0.0124701 -1.51274 0.404904 -1.12015 0.011184 -1.52699 0.369004 -1.13071

Dph3 DPH3, KTI11 homolog (S. cerevisiae)1.99E-06 2.12977 7.43E-07 2.362 0.006683 -1.25413 0.084208 -1.13082

Jdp2 Jun dimerization protein 20.0119205 -1.82787 0.005715 -2.00677 0.877765 -1.03003 0.527776 -1.13084

Kctd17 potassium channel tetramerisation domain containing 170.0094686 -1.48196 0.000242 -2.0673 0.108195 1.23328 0.319055 -1.13111

Arl4d ADP-ribosylation factor-like 4D0.0237253 -1.89085 0.006146 -2.32446 0.725231 1.08683 0.604765 -1.13111

Pigh phosphatidylinositol glycan anchor biosynthesis, class H2.85E-06 -2.89097 2.05E-06 -3.03098 0.432541 -1.07887 0.216677 -1.13112

Pam peptidylglycine alpha-amidating monooxygenase3.42E-08 -8.54538 2.10E-08 -9.80407 0.896117 1.01424 0.273814 -1.13119


Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 45.40E-05 -2.25962 1.99E-05 -2.54875 0.976677 -1.00317 0.272899 -1.13153

Marveld1 MARVEL domain containing 10.0007945 -2.0582 0.000495 -2.17462 0.630516 -1.07147 0.395136 -1.13208

Klc3 kinesin light chain 3 5.81E-05 -1.66931 1.02E-06 -2.4136 0.006322 1.27701 0.099434 -1.13223

Edem3 ER degradation enhancer, mannosidase alpha-like 31.09E-05 -2.10512 5.42E-06 -2.2643 0.5219 -1.0529 0.144609 -1.13252

Rab11fip1 RAB11 family interacting protein 1 (class I)0.0002714 -1.59863 1.31E-05 -2.05223 0.138735 1.13344 0.140774 -1.1326

Vps26b vacuolar protein sorting 26 homolog B (S. pombe)0.0001234 -1.89777 7.02E-05 -2.00217 0.464635 -1.0738 0.215385 -1.13287

Fkbp5 FK506 binding protein 5 4.24E-06 -2.85206 3.35E-07 -4.3047 0.017154 1.33161 0.226248 -1.13347

Nr1d1 nuclear receptor subfamily 1, group D, member 12.41E-05 -2.64107 5.67E-05 -2.36949 0.069929 -1.2634 0.295016 -1.13349

Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 18.98E-06 -1.86692 7.86E-07 -2.36414 0.116156 1.11718 0.081487 -1.1335

Snx8 sorting nexin 8 0.000382 -2.11003 0.000872 -1.92975 0.129959 -1.24029 0.352217 -1.13432

Nipsnap3b nipsnap homolog 3B (C. elegans)1.44E-08 3.24803 5.02E-09 3.84284 0.000455 -1.34211 0.040424 -1.13437

Dip2a DIP2 disco-interacting protein 2 homolog A (Drosophila)9.36E-06 2.6209 0.000165 1.90908 0.086603 1.21005 0.232089 -1.13455

Evi2a ecotropic viral integration site 2A4.80E-05 3.73479 0.000283 2.77722 0.338445 1.18521 0.470861 -1.13464

Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)4.24E-05 -2.10963 0.000202 -1.81831 0.01815 -1.31657 0.210743 -1.13476

RGD1563325Similar to hypothetical protein MGC179430.0001576 2.34492 0.000194 2.28618 0.451775 -1.10636 0.351396 -1.13478

Osap ovary-specific acidic protein0.0001028 -2.11705 3.28E-05 -2.4117 0.972716 1.00374 0.265636 -1.13494

of 148Diabetes

Fabp5 fatty acid binding protein 5, epidermal8.48E-09 6.57317 8.56E-08 4.07032 0.001824 1.42287 0.139467 -1.13496

Fhod1 formin homology 2 domain containing 15.50E-07 2.42848 1.79E-06 2.1397 0.998923 -1.00009 0.075001 -1.13506

RT1-Ba RT1 class II, locus Ba 0.0007352 4.80543 0.001642 3.97339 0.836055 1.06547 0.680497 -1.13509

Lingo4 /// Rorcleucine rich repeat and Ig domain containing 4 /// RAR-related orphan receptor C0.0001627 -3.18232 0.000645 -2.56479 0.08509 -1.40848 0.487917 -1.13516

Rab4a RAB4A, member RAS oncogene family1.03E-06 -1.98148 2.87E-07 -2.24057 0.937573 -1.00419 0.039653 -1.1355

Wwc1 WW and C2 domain containing 11.87E-05 -2.0243 7.41E-05 -1.79126 0.012914 -1.28384 0.142681 -1.13605

RGD1562988Similar to EHM2 7.00E-05 -2.68694 2.82E-05 -3.06946 0.970099 1.00512 0.36059 -1.13655

Rev3l REV3-like, catalytic subunit of DNA polymerase zeta (yeast)1.02E-06 -2.83229 7.75E-07 -2.9433 0.287219 -1.09397 0.14214 -1.13685

Ankrd12 Ankyrin repeat domain 123.94E-06 -3.26734 1.50E-06 -3.83681 0.770379 1.03281 0.264121 -1.13699

Chsy1 chondroitin sulfate synthase 12.32E-07 6.38147 4.23E-07 5.55988 0.939654 1.00908 0.298296 -1.13744

Dct Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)6.31E-10 -10.8159 9.06E-10 -9.73149 0.010087 -1.26555 0.101957 -1.13866

Rtn4 reticulon 4 8.21E-09 5.82242 2.72E-08 4.54188 0.139094 1.12533 0.107463 -1.13917

Mab21l1 mab-21-like 1 (C. elegans)5.91E-06 -3.87179 3.85E-06 -4.19169 0.701218 -1.05264 0.340621 -1.13962

LOC688452 hypothetical protein LOC6884520.0007475 2.77278 0.004564 2.12319 0.501788 1.14556 0.516752 -1.14001

Rab31 RAB31, member RAS oncogene family6.68E-09 21.259 6.20E-09 21.879 0.224634 -1.17342 0.311857 -1.14017

LOC100361542hypothetical protein LOC1003615422.43E-07 -2.52952 4.38E-08 -3.17441 0.138648 1.10061 0.054457 -1.14022

Appbp2 amyloid beta precursor protein (cytoplasmic tail) binding protein 22.28E-06 -2.20386 3.44E-05 -1.73155 0.000503 -1.45161 0.083013 -1.14051

UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)0.0012574 -1.5289 4.15E-05 -2.02157 0.129166 1.15929 0.17068 -1.14056

Fblim1 filamin binding LIM protein 19.24E-08 32.9489 2.63E-07 21.2555 0.152582 1.35883 0.516258 -1.14079

B4galt5 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 50.0013017 2.11123 0.004092 1.84914 0.998296 1.00034 0.417486 -1.14135

Lrpap1 low density lipoprotein receptor-related protein associated protein 10.0003821 -2.7639 0.002247 -2.15266 0.059013 -1.46549 0.468377 -1.14139

Slc5a3 solute carrier family 5 (inositol transporters), member 30.003418 2.68702 0.00643 2.41263 0.921361 -1.02484 0.597898 -1.1414

Peli1 pellino 1 0.0034834 -1.68706 0.000567 -2.02269 0.711602 1.0502 0.330497 -1.14163

Anxa2 Annexin A2 0.0028807 1.90457 0.956621 1.00859 0.010831 1.65368 0.409098 -1.14191

Pf4 platelet factor 4 0.0017447 2.43224 0.00224 2.34494 0.630914 -1.1012 0.510417 -1.1422


Crabp2 cellular retinoic acid binding protein 26.83E-10 3.83233 7.74E-08 2.09232 2.51E-06 1.60137 0.01003 -1.14378

Fads3 fatty acid desaturase 3 1.30E-05 3.70872 5.41E-05 2.93644 0.496001 1.10401 0.360601 -1.14401

LOC683460 hypothetical protein LOC6834600.0034323 -1.67029 0.000299 -2.13664 0.399021 1.11788 0.312601 -1.14431


LOC100911466uncharacterized LOC1009114661.11E-05 -2.51004 6.20E-06 -2.70443 0.544152 -1.06229 0.194713 -1.14456

CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)0.000263 -1.88305 8.15E-05 -2.11637 0.862497 -1.01846 0.22309 -1.14466

Tubb2a tubulin, beta 2a 9.62E-08 5.86723 1.37E-07 5.42626 0.579274 -1.0587 0.208085 -1.14473

STK17B serine/threonine kinase 17b1.04E-05 2.48684 1.82E-05 2.32862 0.479525 -1.07193 0.186887 -1.14477

Ssbp3 single stranded DNA binding protein 31.86E-05 -1.89061 4.81E-06 -2.14643 0.909591 -1.00833 0.092631 -1.14478

of 148 Diabetes

Crot carnitine O-octanoyltransferase4.13E-05 -2.23351 5.16E-05 -2.17943 0.147179 -1.17349 0.211218 -1.14507

Tln2 talin 2 1.76E-05 -2.47854 3.01E-05 -2.32466 0.081426 -1.22093 0.213077 -1.14513

Dapk1 death associated protein kinase 14.30E-07 -3.01931 1.57E-07 -3.51951 0.820804 1.01764 0.106632 -1.14546

Rap1gds1 RAP1, GTP-GDP dissociation stimulator 11.64E-06 2.20739 1.21E-06 2.27936 0.029856 -1.18292 0.065458 -1.14557

Pigp phosphatidylinositol glycan anchor biosynthesis, class P2.31E-06 -1.97718 2.95E-07 -2.43587 0.240705 1.07539 0.04521 -1.14563

Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 11.81E-06 8.19342 6.40E-06 5.93121 0.307558 1.20539 0.449485 -1.14603

Accn2 amiloride-sensitive cation channel 2, neuronal2.51E-06 -2.85473 3.99E-06 -2.68277 0.056786 -1.21964 0.164929 -1.14617

Ehd3 EH-domain containing 3 4.78E-08 24.1411 1.40E-07 16.0321 0.131629 1.31366 0.425214 -1.14626

Tpm3 tropomyosin 3, gamma 9.00E-06 2.03696 4.80E-05 1.76165 0.90665 1.00872 0.093411 -1.14629

Rasal1 RAS protein activator like 1 (GAP1 like)3.16E-06 -2.12809 2.88E-06 -2.14803 0.088828 -1.13683 0.071413 -1.14748

Csrp1 cysteine and glycine-rich protein 12.16E-06 2.79352 4.14E-06 2.56721 0.549768 -1.05495 0.145976 -1.14795

MLL3 myeloid/lymphoid or mixed-lineage leukemia 35.44E-06 -1.60354 1.73E-07 -2.0954 0.019679 1.1381 0.014551 -1.14818

Pex26 peroxisomal biogenesis factor 261.06E-05 -2.23182 2.68E-06 -2.62067 0.79556 1.02239 0.132487 -1.14851

RT1-Db1 RT1 class II, locus Db1 0.001134 4.13517 0.001988 3.64912 0.96347 -1.01367 0.642397 -1.14869

LOC689574 hypothetical protein LOC6895741.02E-06 2.14865 1.21E-06 2.11377 0.067171 -1.13028 0.043208 -1.14893

Znf532 zinc finger protein 532 0.0003413 1.87196 3.99E-05 2.34742 0.008466 -1.44101 0.223467 -1.14914

RGD1309410LOC363020 1.85E-06 -2.51885 1.03E-06 -2.71229 0.413061 -1.06738 0.102555 -1.14935

Nr2f2 nuclear receptor subfamily 2, group F, member 20.0003409 -1.9554 5.34E-05 -2.40188 0.572092 1.06861 0.251338 -1.14947

Akap8l A kinase (PRKA) anchor protein 8-like0.000173 -1.93445 2.51E-05 -2.37693 0.530163 1.06801 0.199639 -1.1505


Rerg RAS-like, estrogen-regulated, growth-inhibitor5.13E-05 -3.30035 1.28E-05 -4.23696 0.495234 1.11523 0.383427 -1.15114

Hdac5 histone deacetylase 5 0.0001975 -2.01314 8.03E-05 -2.21741 0.692105 -1.04553 0.229117 -1.15161

Nedd4 neural precursor cell expressed, developmentally down-regulated 44.01E-05 2.47848 1.59E-05 2.80152 0.046541 -1.30173 0.243463 -1.15163

Klf7 Kruppel-like factor 7 (ubiquitous)0.0017725 2.6452 0.00216 2.56252 0.619287 -1.11567 0.523713 -1.15167

Ifit2 interferon-induced protein with tetratricopeptide repeats 20.524673 1.1493 0.056697 1.59294 0.055813 -1.5963 0.518581 -1.15172

Hectd2 HECT domain containing 2 [0.00144 -1.89245 0.000455 -2.14842 0.917088 -1.01452 0.323235 -1.15175

Paqr5 progestin and adipoQ receptor family member V8.51E-07 -3.08504 4.10E-07 -3.45029 0.732685 -1.02987 0.127868 -1.1518

Cxcl3 chemokine (C-X-C motif) ligand 35.08E-06 25.0015 9.67E-06 19.1831 0.692269 1.13131 0.650347 -1.15204

Lrig3 leucine-rich repeats and immunoglobulin-like domains 30.0001518 -2.24311 2.36E-05 -2.85508 0.433365 1.10448 0.272812 -1.15242

Ninj1 ninjurin 1 1.04E-06 3.15457 4.48E-06 2.5804 0.51884 1.0605 0.141076 -1.15277

Pkib protein kinase (cAMP-dependent, catalytic) inhibitor beta0.212999 2.25856 0.457676 1.5997 0.745946 1.22378 0.818276 -1.15369

Bcl3 B-cell CLL/lymphoma 3 6.41E-05 3.26056 3.55E-05 3.60869 0.155481 -1.27693 0.385764 -1.15374

Col18a1 collagen, type XVIII, alpha 14.65E-07 8.54741 3.90E-07 8.98086 0.225256 -1.21237 0.357414 -1.15386

Ccdc77 coiled-coil domain containing 770.0043883 -1.70106 0.195669 -1.21059 0.007285 -1.62147 0.321005 -1.15395

Svep1 Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.720868 1.08148 0.084223 1.51747 0.052194 -1.61951 0.517059 -1.1542

of 148Diabetes

Calcb calcitonin-related polypeptide, beta1.69E-06 61.3363 2.60E-06 48.9041 0.809516 1.08639 0.677168 -1.15448

Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 31.10E-06 6.20662 2.62E-06 5.10432 0.720411 1.05308 0.332638 -1.15467

Krt17 keratin 17 2.20E-11 202.958 1.99E-11 217.086 0.073972 -1.23546 0.198867 -1.15506

Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.0011177 4.63106 0.00888 2.89619 0.324474 1.38394 0.653154 -1.15541

11-Sep septin 11 0.0033944 -1.82926 0.208689 1.22257 0.000196 -2.58426 0.354064 -1.15555

RGD1308350similar to hypothetical protein MGC132511.37E-07 4.42597 3.69E-07 3.707 0.716543 1.03322 0.134578 -1.15556

Cisd2 CDGSH iron sulfur domain 28.31E-07 2.20494 4.24E-06 1.89368 0.901549 1.00746 0.037753 -1.15575

Ttc38 tetratricopeptide repeat domain 383.10E-06 -2.35209 3.68E-06 -2.30797 0.060104 -1.1779 0.089035 -1.1558

Ctss cathepsin S 0.168728 1.34171 0.009821 1.92369 0.031537 -1.65772 0.476388 -1.15621

Naaa N-acylethanolamine acid amidase4.36E-07 -3.43089 3.06E-07 -3.63401 0.324011 -1.09174 0.12013 -1.15637

Gpr116 G protein-coupled receptor 1165.35E-05 -2.24492 1.58E-06 -3.66372 0.01071 1.41076 0.1988 -1.15683

Rbpms RNA binding protein with multiple splicing9.09E-05 3.45952 5.78E-05 3.75529 0.22193 -1.2558 0.421378 -1.15689

Gpx8 glutathione peroxidase 82.42E-05 3.6514 0.000132 2.77736 0.416795 1.13629 0.357054 -1.15701

Dcxr dicarbonyl L-xylulose reductase4.62E-06 -2.14049 4.37E-05 -1.75315 0.001152 -1.41328 0.070635 -1.15753

Arsb arylsulfatase B 5.14E-05 2.04186 1.91E-05 2.26603 0.025293 -1.28463 0.147644 -1.15755

Tbc1d19 TBC1 domain family, member 190.0098811 -1.417 0.56391 -1.06436 0.003103 -1.54124 0.195368 -1.15768

Chrnb4 cholinergic receptor, nicotinic, beta 45.06E-06 2.10069 3.44E-05 1.77356 0.750454 1.02307 0.067449 -1.15774

Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.0005225 -5.41662 0.001634 -4.09405 0.196685 -1.53178 0.641481 -1.15777

Osbpl5 oxysterol binding protein-like 59.30E-06 -1.90148 3.75E-06 -2.06539 0.353532 -1.06616 0.054067 -1.15806

Spa17 sperm autoantigenic protein 170.0002981 -2.30049 0.001349 -1.93273 0.047421 -1.37847 0.31581 -1.1581

Gca grancalcin 8.19E-06 -2.55357 1.98E-06 -3.09925 0.630165 1.04781 0.153883 -1.15831

Tet3 tet methylcytosine dioxygenase 30.0011472 -1.89213 0.000275 -2.21413 0.940337 1.01004 0.288006 -1.15855

Arhgap27 Rho GTPase activating protein 277.07E-05 -2.47925 0.000348 -2.05561 0.024832 -1.39733 0.259959 -1.15856

Mfsd4 major facilitator superfamily domain containing 40.0001232 -4.37954 8.09E-05 -4.79843 0.800085 -1.05755 0.510173 -1.1587

RT1-T24-3 RT1 class I, locus T24, gene 30.0352184 2.6112 0.073809 2.18105 0.933746 1.03307 0.707556 -1.15889

H19 H19, imprinted maternally expressed transcript1.85E-05 6.27061 4.68E-05 5.03272 0.73265 1.07482 0.489383 -1.15924

LOC684122 similar to development and differentiation enhancing factor-like 12.80E-06 -2.4375 3.93E-06 -2.34368 0.041048 -1.20564 0.090851 -1.15924

Jph2 junctophilin 2 0.0001298 2.53725 0.001443 1.90584 0.338954 1.14803 0.30699 -1.15965

Plau plasminogen activator, urokinase4.79E-05 8.46039 0.000147 6.18266 0.557371 1.18 0.598691 -1.15966

CPEB3 cytoplasmic polyadenylation element binding protein 3 [0.0001023 -3.7635 6.17E-05 -4.15287 0.795943 -1.0512 0.449814 -1.15996

Elk3 ELK3, member of ETS oncogene family1.94E-07 2.01743 8.68E-07 1.78285 0.572326 -1.02553 0.008377 -1.16046

ZAK sterile alpha motif and leucine zipper containing kinase AZK4.97E-06 3.33363 1.26E-05 2.894 0.947112 -1.0077 0.22022 -1.16078

RGD1562037similar to OTTHUMP000000462556.31E-08 3.88103 3.85E-07 2.93132 0.104758 1.14012 0.070486 -1.16127

Pragmin pragma of Rnd2 3.78E-05 2.10058 0.00028 1.74611 0.708057 1.03592 0.138686 -1.16129

Ifrd1 interferon-related developmental regulator 10.0002332 2.33498 0.001554 1.88134 0.637663 1.06812 0.297233 -1.16198

of 148 Diabetes

Zadh2 zinc binding alcohol dehydrogenase, domain containing 23.62E-08 -2.5067 7.47E-09 -3.07259 0.272697 1.05476 0.010556 -1.16211

Arpc1b actin related protein 2/3 complex, subunit 1B4.57E-09 7.12207 8.12E-09 6.20818 0.865796 -1.01307 0.078012 -1.1622

NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit4.79E-05 1.92514 1.29E-05 2.18933 0.009874 -1.32176 0.107359 -1.16226

Wee1 wee 1 homolog (S. pombe)0.0004138 -1.89031 1.44E-05 -2.78838 0.062417 1.2691 0.209178 -1.16231

Bcl11b B-cell CLL/lymphoma 11B (zinc finger protein)0.0002944 2.35364 0.036551 1.42284 0.036634 1.42255 0.314833 -1.16283

RGD1562629similar to neurobeachin 3.95E-05 -2.43286 0.000207 -2.0189 0.015138 -1.40134 0.205783 -1.1629

LOC100912730kelch repeat and BTB domain-containing protein 7-like3.54E-06 -4.52164 4.32E-06 -4.34733 0.194118 -1.20968 0.29334 -1.16305

Pycr1 pyrroline-5-carboxylate reductase 19.93E-06 3.88662 2.78E-05 3.25561 0.855477 1.02642 0.307553 -1.16309


Xdh xanthine dehydrogenase1.08E-06 28.6307 8.47E-07 31.9227 0.338499 -1.29726 0.570048 -1.16348

Il13ra1 interleukin 13 receptor, alpha 11.07E-07 3.56935 2.71E-07 3.09537 0.903977 -1.009 0.068557 -1.16351

Raver2 ribonucleoprotein, PTB-binding 20.0007609 -2.13694 0.000491 -2.25388 0.515358 -1.10316 0.324445 -1.16353

Fut2 fucosyltransferase 2 (secretor status included)4.32E-05 3.2311 0.000924 2.11128 0.09826 1.31506 0.330528 -1.16375

Degs2 degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)3.84E-05 4.644 9.02E-05 3.90486 0.911323 1.02191 0.444334 -1.16379

Arih1 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)1.61E-06 2.13295 2.81E-06 2.02155 0.145376 -1.10303 0.037197 -1.16382

Phf17 PHD finger protein 17 0.0002291 -2.19523 7.79E-05 -2.50571 0.879497 -1.01968 0.257603 -1.16389

Rasl11b RAS-like family 11 member B0.0029151 -2.07933 0.001078 -2.37274 0.910497 -1.02033 0.406067 -1.1643

Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 10.11412 1.53673 0.018112 2.04932 0.106877 -1.5528 0.547387 -1.16441

Tmem59 transmembrane protein 591.27E-06 -1.78325 2.62E-07 -2.03267 0.646957 -1.02164 0.009562 -1.16453

Col5a1 Collagen, type V, alpha 10.0001512 2.39646 0.000893 1.95154 0.694713 1.05444 0.27577 -1.16459

Spast spastin 1.06E-06 -2.2401 2.48E-07 -2.64532 0.827714 1.01388 0.037636 -1.16473

RGD1561459similar to RIKEN cDNA 1810020D171.16E-06 -2.79877 1.63E-07 -3.76221 0.10836 1.15367 0.089354 -1.16518

Homer2 homer homolog 2 (Drosophila)5.66E-06 -2.30254 1.85E-06 -2.62853 0.801507 -1.02074 0.088906 -1.16526

Cnfn cornifelin 1.68E-05 24.3741 8.52E-06 33.0821 0.226593 -1.58174 0.673499 -1.16539

Mgst3 microsomal glutathione S-transferase 31.04E-05 -1.85119 1.25E-06 -2.26006 0.483793 1.04759 0.042025 -1.16541

Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 236.65E-07 -2.83835 5.10E-07 -2.9438 0.156456 -1.12381 0.074196 -1.16556

Rhoc ras homolog gene family, member C8.57E-06 2.25273 0.000105 1.77667 0.332007 1.08759 0.095885 -1.16583

Sfrp1 secreted frizzled-related protein 10.0002714 -1.97624 6.41E-05 -2.31314 0.97337 1.00382 0.202365 -1.16602

Napg N-ethylmaleimide-sensitive factor attachment protein, gamma8.37E-07 -2.49415 4.96E-07 -2.6591 0.219415 -1.09391 0.051819 -1.16625

Vezf1 vascular endothelial zinc finger 12.23E-06 -2.74431 5.48E-07 -3.36038 0.580958 1.04985 0.106317 -1.16635

Ankh ankylosis, progressive homolog (mouse)0.000508 -2.01692 0.000146 -2.32626 0.930856 -1.01127 0.253897 -1.16637

Bre brain and reproductive organ-expressed protein9.09E-07 -2.53355 6.49E-07 -2.64111 0.141923 -1.11945 0.056344 -1.16698

Hspb6 heat shock protein, alpha-crystallin-related, B61.65E-05 -2.71097 1.35E-05 -2.78661 0.278003 -1.13534 0.194442 -1.16702

Cage1 cancer antigen 1 0.0001377 -2.211 0.000108 -2.27531 0.311837 -1.13422 0.221691 -1.16721

Nipbl Nipped-B homolog (Drosophila)6.76E-06 -2.04331 5.51E-06 -2.08404 0.087523 -1.1444 0.056225 -1.16721

of 148Diabetes

Tpm2 tropomyosin 2, beta 1.16E-07 19.4279 2.02E-08 40.6158 0.00076 -2.44037 0.387908 -1.16731

Cpsf6 cleavage and polyadenylation specific factor 61.71E-05 -2.8283 1.92E-05 -2.78255 0.172454 -1.18676 0.212275 -1.16756

Wipf1 WAS/WASL interacting protein family, member 11.37E-06 -4.72253 9.91E-07 -5.04707 0.483451 -1.09375 0.236501 -1.16891

Synm synemin, intermediate filament protein2.07E-07 -5.02251 7.68E-08 -6.24554 0.551339 1.0637 0.154381 -1.16905

Sytl2 synaptotagmin-like 2 0.000403 3.30557 0.00048 3.20306 0.561703 -1.1328 0.470005 -1.16905

Wbp1 WW domain binding protein 13.86E-05 -1.97584 1.79E-05 -2.13184 0.364707 -1.08374 0.098545 -1.16931

Mier3 mesoderm induction early response 1, family member 35.21E-06 -2.12125 1.66E-06 -2.39681 0.632957 -1.0356 0.056315 -1.17012

RORA RAR-related orphan receptor A2.17E-05 -2.64286 1.59E-06 -3.9601 0.055311 1.28046 0.191962 -1.17021

Gstm5 glutathione S-transferase, mu 50.0001068 5.03007 0.00014 4.73299 0.684873 -1.10121 0.511645 -1.17033

Kazald1 Kazal-type serine peptidase inhibitor domain 10.000327 -1.92137 2.85E-05 -2.52271 0.323743 1.12147 0.186152 -1.17077

Map1lc3a microtubule-associated protein 1 light chain 3 alpha2.18E-06 -2.20015 9.84E-07 -2.39903 0.310997 -1.07384 0.043496 -1.17091

Car5b carbonic anhydrase 5b, mitochondrial2.98E-05 -2.13279 2.38E-06 -2.89614 0.137661 1.1597 0.117035 -1.17092

Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.0009288 2.38024 0.011738 1.73702 0.382889 1.16995 0.379684 -1.17125

Cbr4 carbonyl reductase 4 8.38E-06 -2.70371 8.42E-06 -2.70216 0.148687 -1.17197 0.149976 -1.1713

Cugbp1 CUG triplet repeat, RNA binding protein 11.37E-07 3.22529 1.43E-07 3.20674 0.056261 -1.16473 0.04932 -1.17146

Mgmt O-6-methylguanine-DNA methyltransferase2.71E-09 -5.32712 3.69E-09 -4.99608 0.005637 -1.24911 0.028486 -1.17148

Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 22.12E-06 3.19493 2.52E-05 2.30201 0.117511 1.18472 0.140085 -1.17149

Flnb filamin, beta 1.88E-05 3.33849 0.00016 2.44323 0.284886 1.16626 0.271779 -1.17163

Ugcg UDP-glucose ceramide glucosyltransferase0.0005777 2.1939 0.011527 1.59391 0.292622 1.17479 0.300177 -1.17164

Kcnk5 potassium channel, subfamily K, member 50.0001464 2.39616 0.000837 1.95871 0.749345 1.04381 0.2557 -1.17199

Gmds GDP-mannose 4, 6-dehydratase2.28E-05 2.31144 0.000568 1.69505 0.15252 1.16352 0.136133 -1.172

Podn /// Scp2podocan /// sterol carrier protein 21.96E-05 -1.74292 3.52E-06 -2.01247 0.816034 -1.01507 0.034055 -1.17206

Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)7.71E-06 -2.96457 1.79E-06 -3.73764 0.517468 1.07534 0.176423 -1.17243

Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 10.0003191 3.02729 0.019417 1.71123 0.056143 1.50861 0.41251 -1.17265

Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 80.0003951 2.46965 0.001018 2.18271 0.823358 -1.03647 0.334898 -1.17272

Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein)0.0001376 -2.39795 0.591438 -1.07454 7.04E-05 -2.61792 0.249579 -1.1731


Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit2.40E-05 -2.15955 8.61E-06 -2.42116 0.621074 -1.0466 0.108752 -1.17339

CTNND2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)1.47E-05 -4.41052 1.24E-05 -4.56628 0.455511 -1.13347 0.34594 -1.1735

Stk17b Serine/threonine kinase 17b7.00E-05 2.13988 0.000181 1.94282 0.547911 -1.0658 0.153113 -1.1739

Tnf tumor necrosis factor (TNF superfamily, member 2)0.426857 1.26266 0.059416 1.84354 0.089013 -1.71458 0.57996 -1.17433

Prpf39 PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)1.28E-05 -1.94769 1.84E-06 -2.36911 0.63099 1.0358 0.051943 -1.17434

Prom2 prominin 2 0.0007652 -1.49286 1.59E-05 -2.01369 0.106541 1.14858 0.06788 -1.17439

Fam81a family with sequence similarity 81, member A0.0001556 -2.35666 7.88E-05 -2.57264 0.584007 -1.07594 0.245259 -1.17455

MAN1A2 mannosidase, alpha, class 1A, member 29.51E-06 2.1738 4.31E-05 1.88132 0.839545 -1.01663 0.075448 -1.17468

of 148 Diabetes

Flt1 fms-related tyrosine kinase 10.0534317 -2.08951 0.027839 -2.39455 0.941047 -1.02516 0.634017 -1.17481

Gbp4 guanylate binding protein 42.32E-05 3.36678 7.90E-07 6.6944 0.000289 -2.33667 0.279299 -1.17517

Myo5c myosin VC 8.13E-07 -7.49105 4.90E-07 -8.58455 0.868201 -1.02566 0.306254 -1.17538

Nr1d2 Nuclear receptor subfamily 1, group D, member 28.30E-06 -2.72418 2.99E-06 -3.15083 0.874927 -1.01637 0.144147 -1.17555

HLF hepatic leukemia factor 1.36E-06 -7.47887 8.89E-07 -8.37874 0.766727 -1.04966 0.33472 -1.17596

B3galtl-ps1 beta 1,3-galactosyltransferase-like, pseudogene 18.00E-07 2.9903 1.27E-06 2.80658 0.25191 -1.1042 0.077475 -1.17647

ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 13.01E-07 -3.31814 2.21E-07 -3.48378 0.17931 -1.12073 0.068863 -1.17668

Map4k3 mitogen-activated protein kinase kinase kinase kinase 34.22E-05 -2.02466 6.39E-05 -1.94587 0.0499 -1.22442 0.100705 -1.17677

Amn amnionless homolog (mouse)0.0008687 2.72105 0.001785 2.43699 0.792362 -1.05428 0.425287 -1.17717

Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d0.0158233 -1.44737 0.000226 -2.15353 0.089512 1.26385 0.215156 -1.17727

Mks1 Meckel syndrome, type 18.67E-07 -2.47086 1.72E-06 -2.28672 0.007018 -1.27239 0.040553 -1.17756

Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 16.38E-08 3.83849 5.85E-08 3.89641 0.036601 -1.19535 0.050815 -1.17758

Klc3 kinesin light chain 3 0.0035365 -1.59081 0.000162 -2.12992 0.29349 1.13649 0.187752 -1.1781

Glyctk glycerate kinase 1.97E-06 -2.10438 1.11E-06 -2.23093 0.122741 -1.11163 0.028035 -1.17848

Ercc5 excision repair cross-complementing rodent repair deficiency, complementation group 54.28E-05 -1.90731 1.31E-05 -2.13737 0.548992 -1.05165 0.075624 -1.1785

Nradd neurotrophin receptor associated death domain1.46E-07 4.33837 5.38E-07 3.45651 0.486858 1.06494 0.09346 -1.17859

TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)0.0002861 -2.97444 0.000131 -3.39183 0.856868 -1.03379 0.383297 -1.17885

Aebp1 AE binding protein 1 7.39E-07 4.16469 3.74E-07 4.7482 0.02118 -1.34422 0.150103 -1.17903

Sepp1 selenoprotein P, plasma, 10.0062718 -1.93275 0.001355 -2.36539 0.841292 1.0378 0.384739 -1.17928

Depdc7 DEP domain containing 74.89E-05 3.19616 0.000321 2.42605 0.475188 1.1169 0.295583 -1.17955

Rnpc3 RNA-binding region (RNP1, RRM) containing 30.258667 -1.36642 0.018995 -2.12191 0.316054 1.316 0.53718 -1.18001

Klf3 Kruppel-like factor 3 (basic)4.39E-05 -1.78799 6.67E-06 -2.11853 0.958537 1.00391 0.05207 -1.18025

Arl4c ADP-ribosylation factor-like 4C8.84E-07 5.40393 1.98E-06 4.56482 0.982119 1.0029 0.221981 -1.1804

LOC100910231 /// LOC499124zinc finger protein 82-like /// mouse zinc finger protein 14-like0.261018 -1.68121 0.118958 -2.11696 0.884438 1.06658 0.709213 -1.18059

Snx25 sorting nexin 25 8.93E-05 2.22785 0.00033 1.93892 0.810669 -1.02779 0.171395 -1.18095

Sprr1b small proline-rich protein 1B (cornifin)1.23E-06 202.042 1.24E-06 201.148 0.703589 -1.17622 0.695971 -1.18145

Ifi44l Interferon-induced protein 44-like0.842149 1.11289 0.189969 2.10574 0.160385 -2.23554 0.756608 -1.18149

Fstl1 follistatin-like 1 0.0001936 2.63527 0.002554 1.90855 0.328266 1.16865 0.29756 -1.18151

Jakmip1 janus kinase and microtubule interacting protein 16.53E-05 -6.15204 0.001415 -3.14249 0.008166 -2.31402 0.506068 -1.18201

LOC683460 hypothetical protein LOC6834600.0014044 -1.94867 0.001045 -2.01345 0.363202 -1.14429 0.265165 -1.18233

Pric285 peroxisomal proliferator-activated receptor A interacting complex 2850.000278 2.52106 0.00118 2.09541 0.914479 1.01684 0.296627 -1.18321

Ptdss2 phosphatidylserine synthase 21.07E-06 -2.76417 4.38E-07 -3.13117 0.588764 -1.04452 0.061361 -1.18321

Rhobtb3 Rho-related BTB domain containing 32.05E-05 2.37298 0.000102 1.99588 0.963061 1.00466 0.121919 -1.18342

Hip1 huntingtin interacting protein 11.11E-06 3.63837 8.68E-06 2.67757 0.200538 1.14774 0.12579 -1.18392

Rhcg Rh family, C glycoprotein6.35E-08 14.2715 1.62E-07 10.5777 0.380146 1.13955 0.264202 -1.18397

of 148Diabetes

Psme4 proteasome (prosome, macropain) activator subunit 41.08E-07 -3.94889 2.98E-08 -5.04428 0.358355 1.07872 0.061453 -1.18417

Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 10.0034486 2.17266 0.155552 1.34567 0.140407 1.36323 0.397651 -1.18436

LOC499330 similar to Nicotinamide riboside kinase 11.03E-05 -2.65569 1.06E-05 -2.64361 0.120486 -1.19015 0.129092 -1.18474

Epb4.1l1 erythrocyte protein band 4.1-like 13.81E-08 -3.073 8.68E-09 -3.87344 0.298637 1.06381 0.015861 -1.18487

Ncoa3 nuclear receptor coactivator 32.32E-06 -3.11679 1.38E-06 -3.37454 0.373162 -1.09447 0.11407 -1.18497

RGD1311595similar to KIAA2026 protein5.72E-06 -1.96653 4.21E-07 -2.58912 0.141117 1.11045 0.029062 -1.18564

Adam8 ADAM metallopeptidase domain 81.34E-06 3.50145 4.76E-06 2.88847 0.828789 1.02219 0.120755 -1.1859

Ptplad2 protein tyrosine phosphatase-like A domain containing 22.86E-06 -8.35158 5.97E-06 -6.85547 0.080108 -1.44481 0.380262 -1.18598

PAK2 p21 protein (Cdc42/Rac)-activated kinase 23.55E-06 -2.09527 1.58E-06 -2.27703 0.220661 -1.09145 0.03204 -1.18612

Vldlr very low density lipoprotein receptor1.34E-06 -2.27916 2.50E-07 -2.783 0.665987 1.02934 0.029433 -1.18626

Fam132a family with sequence similarity 132, member A2.60E-05 3.47873 0.000134 2.69388 0.575657 1.08833 0.272265 -1.18654

Vof16 ischemia related factor vof-160.0004174 4.14687 0.019936 2.04223 0.060836 1.71104 0.50672 -1.18675

Mdfi MyoD family inhibitor 7.43E-05 2.04031 0.000547 1.70233 0.921822 1.00977 0.112124 -1.18694

Hebp2 heme binding protein 2 5.52E-06 -2.56304 2.84E-06 -2.795 0.36808 -1.08846 0.089884 -1.18697


Cml3 camello-like 3 7.73E-08 -11.5974 2.46E-07 -8.27502 0.005011 -1.66418 0.23239 -1.18743

Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide2.98E-05 3.63449 1.52E-05 4.11783 0.088488 -1.34546 0.293968 -1.18753

Pxmp2 peroxisomal membrane protein 21.28E-06 -2.68892 5.45E-06 -2.26393 0.002076 -1.41127 0.055509 -1.18822

Tcf3 transcription factor 3 0.0027353 -1.86066 0.000379 -2.34529 0.6959 1.06075 0.269861 -1.18828

Vmp1 vacuole membrane protein 11.28E-05 3.00307 4.09E-05 2.55465 0.927785 -1.01092 0.175687 -1.18837

RGD1563888similar to DNA segment, Chr 16, ERATO Doi 472, expressed1.92E-06 -3.1547 4.77E-07 -3.96443 0.573221 1.057 0.104123 -1.18891

Satb1 SATB homeobox 1 3.63E-07 -3.5218 3.11E-07 -3.61321 0.114509 -1.15895 0.071264 -1.18903

Lmna lamin A 2.75E-06 4.46887 1.48E-05 3.30723 0.350712 1.13625 0.215662 -1.18921

MKRN1 makorin ring finger protein 13.25E-06 -2.65742 1.08E-06 -3.09481 0.812354 -1.02134 0.078517 -1.18944

Clic3 chloride intracellular channel 38.57E-10 -2.27764 5.63E-10 -2.38165 0.000921 -1.13769 0.000128 -1.18965

Acvr2b activin A receptor, type IIB0.0037227 -1.68884 0.000136 -2.41823 0.190874 1.20351 0.216949 -1.18976

Sccpdh saccharopine dehydrogenase (putative)1.74E-05 2.02801 0.000117 1.7196 0.910517 -1.00908 0.056011 -1.19005

MGC108823 similar to interferon-inducible GTPase0.113307 3.1508 0.111451 3.17288 0.786258 -1.19844 0.794279 -1.1901

Abca5 ATP-binding cassette, sub-family A (ABC1), member 50.0002669 -2.14106 5.43E-05 -2.60393 0.865597 1.02179 0.19552 -1.19026

Dd25 hypothetical protein Dd259.88E-09 -4.72247 9.42E-09 -4.76773 0.034669 -1.17912 0.027588 -1.19042

Cars cysteinyl-tRNA synthetase5.63E-06 2.5216 3.48E-05 2.0604 0.760646 1.02799 0.081558 -1.19052

Lrsam1 leucine rich repeat and sterile alpha motif containing 10.0001394 -1.74956 5.33E-06 -2.40331 0.122091 1.1531 0.066388 -1.19128

Atg10 autophagy-related 10 (S. cerevisiae)0.0038346 -2.25078 0.003156 -2.31571 0.487798 -1.15804 0.410562 -1.19144

Fam89a family with sequence similarity 89, member A0.0574377 -1.7348 0.004557 -2.63412 0.357692 1.27441 0.500818 -1.19145

Aktip AKT interacting protein 1.12E-05 -1.83144 2.07E-06 -2.1314 0.71373 -1.02415 0.023321 -1.19189

of 148 Diabetes

Cpe carboxypeptidase E 0.0008422 7.66235 0.000253 11.5469 0.17425 -1.79704 0.666134 -1.19248

Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 28.27E-05 -4.16473 0.00012 -3.86941 0.235885 -1.28398 0.392162 -1.19293

Napg N-ethylmaleimide-sensitive factor attachment protein, gamma0.0002295 -2 0.000495 -1.85467 0.050724 -1.28681 0.146141 -1.1933

LOC100302372hypothetical protein LOC1003023721.22E-07 4.96088 1.18E-07 4.99534 0.080826 -1.2019 0.090788 -1.19361

Gnptab N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits1.01E-05 2.73019 5.49E-05 2.21801 0.77474 1.0309 0.122806 -1.19403

Cfl2 cofilin 2, muscle 0.0002943 2.35606 0.000141 2.59654 0.086941 -1.31612 0.24308 -1.19423

Syt17 synaptotagmin XVII 0.0037603 -1.83195 0.000262 -2.53144 0.35953 1.15699 0.270489 -1.19433

Mical1 microtubule associated monoxygenase, calponin and LIM domain containing 11.39E-05 3.50079 2.81E-05 3.12152 0.647937 -1.06555 0.219872 -1.19501

Ppm1l protein phosphatase 1 (formerly 2C)-like2.45E-05 2.97255 0.000866 1.91254 0.070028 1.30048 0.193971 -1.19513

Nsbp1 nucleosomal binding protein 17.35E-06 -2.94652 1.53E-05 -2.66247 0.029761 -1.32278 0.130942 -1.19526

Ppp1r36 protein phosphatase 1, regulatory subunit 366.70E-08 6.52537 1.95E-07 5.13662 0.564054 1.06196 0.11066 -1.19624

Tsga14 testis specific, 14 0.0013797 -1.47416 2.54E-05 -2.01202 0.142636 1.14091 0.058051 -1.19629

Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B0.0007171 2.3078 0.007649 1.74509 0.542303 1.10536 0.287587 -1.1964

Nfil3 nuclear factor, interleukin 3 regulated3.22E-05 3.72331 0.000337 2.55798 0.248493 1.2166 0.287866 -1.19642

Cry2 cryptochrome 2 (photolyase-like)1.73E-06 -2.97988 8.05E-07 -3.34203 0.48105 -1.06757 0.076238 -1.19731

S1pr1 sphingosine-1-phosphate receptor 19.55E-07 -19.2751 1.28E-06 -17.2553 0.226049 -1.33772 0.439949 -1.19755

Vwa1 von Willebrand factor A domain containing 15.10E-10 8.19657 6.13E-10 7.81173 0.060013 -1.14154 0.017488 -1.19778

Tgm1 transglutaminase 1, K polypeptide8.65E-05 3.95172 0.000177 3.45635 0.811453 -1.04772 0.367508 -1.19788

Arhgef37 Rho guanine nucleotide exchange factor (GEF) 371.06E-05 -2.65323 4.53E-06 -2.98439 0.547595 -1.06517 0.10997 -1.19812

Arhgef37 Rho guanine nucleotide exchange factor (GEF) 371.06E-05 -2.65323 4.53E-06 -2.98439 0.547595 -1.06517 0.10997 -1.19812

Klc1 kinesin light chain 1 8.43E-06 2.0667 1.48E-06 2.49407 0.000941 -1.44657 0.037008 -1.19869

Mrrf mitochondrial ribosome recycling factor4.52E-05 -1.79077 4.89E-06 -2.19818 0.754919 1.02392 0.038229 -1.19882

Lrrc4 leucine rich repeat containing 42.41E-06 -5.42558 5.09E-06 -4.628 0.04453 -1.4058 0.240083 -1.19914

LOC685067 similar to guanylate binding protein family, member 65.93E-06 17.262 5.52E-07 48.8153 0.002009 -3.39109 0.522412 -1.19915

Rdh10 Retinol dehydrogenase 10 (all-trans)0.0002594 2.50518 0.001082 2.09037 0.994265 -1.0011 0.2538 -1.19976

TLN2 talin 2 8.34E-06 -2.376 2.92E-06 -2.70362 0.55627 -1.05444 0.067859 -1.19984

LOC688430 similar to Cofilin-1 (Cofilin, non-muscle isoform)9.28E-07 3.07492 3.11E-06 2.60834 0.838638 -1.01781 0.061674 -1.19988

RGD1305679similar to 9530008L14Rik protein1.15E-05 2.40758 1.58E-05 2.32054 0.150586 -1.15668 0.081548 -1.20006

Fam102b family with sequence similarity 102, member B1.47E-06 5.11152 1.80E-05 3.21985 0.062748 1.32254 0.195863 -1.20034

Fam210b Family with sequence similarity 210, member B3.02E-05 -1.79902 3.29E-06 -2.20594 0.769055 1.02141 0.030672 -1.20048

LOC690286 similar to hepatic leukemia factor2.23E-06 -9.63495 1.16E-06 -11.8014 0.918578 1.02023 0.363692 -1.20057

Eif5a2 eukaryotic translation initiation factor 5A27.38E-06 2.7187 0.000512 1.7322 0.025898 1.30715 0.099418 -1.2007

Socs6 suppressor of cytokine signaling 65.95E-07 2.21904 2.18E-06 1.96003 0.325614 -1.06063 0.011607 -1.20078

Chrnb3 cholinergic receptor, nicotinic, beta 30.0001891 -2.626 5.51E-05 -3.16241 0.985209 1.00285 0.253186 -1.20085

Znrf2 zinc and ring finger 2 3.89E-05 -3.383 6.22E-06 -4.77121 0.314693 1.17445 0.256838 -1.20086

of 148Diabetes

Arl6ip5 ADP-ribosylation-like factor 6 interacting protein 56.43E-05 -2.30863 7.87E-05 -2.25489 0.098071 -1.22957 0.135737 -1.20094

Cryl1 crystallin, lambda 1 4.91E-08 -2.87345 8.20E-09 -3.76062 0.151371 1.0895 0.009464 -1.20123

LOC100912349 /// LOC302022nidogen-2-like /// similar to nidogen 2 protein0.0002105 1.9567 3.13E-05 2.40961 0.005781 -1.47944 0.118678 -1.20136

Tpm2 tropomyosin 2, beta 4.60E-05 2.28208 0.001112 1.67351 0.258789 1.13461 0.114713 -1.20187

Parvb Parvin, beta 4.12E-07 4.35681 1.13E-06 3.63874 0.967488 -1.00417 0.099639 -1.20233

Podn /// Scp2podocan /// sterol carrier protein 24.41E-06 -1.71883 6.38E-07 -2.00916 0.579735 -1.02907 0.005864 -1.20289

Syf2 SYF2 homolog, RNA splicing factor (S. cerevisiae)1.55E-06 -2.27573 4.31E-07 -2.64127 0.600235 -1.0365 0.022744 -1.20299

Ptprr protein tyrosine phosphatase, receptor type, R0.0014435 2.88646 0.003686 2.46843 0.901341 -1.02896 0.431066 -1.20322

Galnt3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (Gal4.93E-07 2.45187 6.32E-07 2.38311 0.034529 -1.16997 0.016961 -1.20373

Harbi1 harbinger transposase derived 10.0001383 -1.51678 2.95E-06 -2.02417 0.131109 1.10859 0.016407 -1.2038

N4bp2l1 NEDD4 binding protein 2-like 10.0011503 -2.72644 6.03E-05 -4.74029 0.108472 1.44422 0.388498 -1.20386

Creg1 cellular repressor of E1A-stimulated genes 10.0004252 1.96944 0.000311 2.03449 0.101123 -1.24362 0.153626 -1.20386

Tns1 Tensin 1 0.0002052 2.41127 0.014923 1.52739 0.083527 1.31132 0.213038 -1.20389

Fmo5 flavin containing monooxygenase 50.0041529 3.13441 0.075752 1.79989 0.23624 1.44634 0.537423 -1.20404

Tef thyrotrophic embryonic factor0.0002666 -2.47511 0.000103 -2.83233 0.735588 -1.05267 0.240366 -1.20459

Slc16a3 solute carrier family 16, member 3 (monocarboxylic acid transporter 4)2.98E-05 5.52824 2.23E-05 5.92165 0.243721 -1.29059 0.384822 -1.20485

RGD1306148similar to KIAA0368 3.44E-05 -2.15477 1.80E-05 -2.31363 0.249392 -1.12221 0.079487 -1.20495

Mid1 Midline 1 0.114438 1.46522 0.014996 1.94517 0.061011 -1.59964 0.412462 -1.20495

Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 81.78E-06 -2.13909 5.31E-07 -2.4354 0.384937 -1.05849 0.016648 -1.20511

LOC681740 similar to jumonji protein4.43E-05 -2.16386 1.74E-05 -2.40451 0.425176 -1.08463 0.089593 -1.20526

Kdsr 3-ketodihydrosphingosine reductase0.0001785 -1.95347 1.80E-05 -2.51854 0.529171 1.06956 0.105038 -1.20542

Nbl1 neuroblastoma, suppression of tumorigenicity 10.0096083 -1.50231 0.000342 -2.04606 0.340128 1.12981 0.15906 -1.20546

RGD1565926RGD1565926 9.28E-05 -1.68709 0.005588 -1.31374 0.000315 -1.54936 0.032476 -1.20649

Foxn3 Forkhead box N3 7.11E-06 -1.62769 3.59E-07 -2.05485 0.371351 1.04608 0.004226 -1.20682

Klc4 kinesin light chain 4 6.69E-05 -1.98936 8.39E-06 -2.49439 0.687788 1.03877 0.073098 -1.20707

Pkp2 plakophilin 2 0.13699 1.1846 0.003401 1.52358 0.002639 -1.55287 0.103288 -1.20738

Pld3 phospholipase D family, member 31.39E-05 2.38084 0.000864 1.61357 0.062707 1.22185 0.076347 -1.2076

Pter phosphotriesterase related0.361297 1.15776 0.021077 1.54196 0.013761 -1.60864 0.247311 -1.20783

Hpd 4-hydroxyphenylpyruvate dioxygenase3.95E-06 8.03225 1.07E-05 6.19212 0.714488 1.07394 0.344969 -1.20786

Adra2a adrenergic, alpha-2A-, receptor0.0003218 2.00008 0.002216 1.66642 0.956702 -1.00649 0.140277 -1.20801

Lrrc8c leucine rich repeat containing 8 family, member C6.50E-06 13.5618 8.90E-06 12.1868 0.750138 -1.08648 0.472174 -1.20906

Camk2d calcium/calmodulin-dependent protein kinase II delta7.08E-05 2.22386 0.002442 1.59221 0.214095 1.1552 0.113648 -1.20907

Rae1 RAE1 RNA export 1 homolog (S. pombe)0.45221 -1.09207 0.254416 1.14666 0.005823 -1.5148 0.126058 -1.20968

Fuk fucokinase 0.0003373 -1.87508 0.000108 -2.10202 0.49043 -1.07918 0.10851 -1.20979

Nipbl Nipped-B homolog (Drosophila)0.0002058 -2.4576 7.86E-05 -2.80852 0.694998 -1.05864 0.211286 -1.2098

of 148 Diabetes

Hist3h2a histone cluster 3, H2a 0.0037231 -1.82964 0.113018 -1.30467 0.007638 -1.69688 0.2379 -1.21001

Mrps27 mitochondrial ribosomal protein S275.93E-05 2.87094 0.000259 2.34661 0.938677 1.01098 0.203034 -1.21015

Sult2b1 sulfotransferase family, cytosolic, 2B, member 15.22E-06 5.62884 5.15E-05 3.54704 0.132952 1.31109 0.272256 -1.21038

Tmem183a transmembrane protein 183A2.51E-07 2.02072 1.13E-06 1.78436 0.170237 -1.06916 0.00258 -1.21079

Ergic3 ERGIC and golgi 3 1.17E-05 2.12348 2.61E-05 1.96412 0.187294 -1.11999 0.040908 -1.21086


Tnfrsf26 tumor necrosis factor receptor superfamily, member 260.0035929 2.67418 0.020146 2.01214 0.711371 1.09715 0.450694 -1.21134

Efemp2 EGF-containing fibulin-like extracellular matrix protein 22.69E-05 2.85755 0.000148 2.28549 0.807438 1.03141 0.155585 -1.21222

Cpne3 copine III 2.87E-05 -1.66934 2.53E-06 -2.03322 0.940213 1.00469 0.012898 -1.21229

EXPH5 exophilin 5 4.06E-05 -2.49352 8.69E-06 -3.0859 0.860713 1.0207 0.126719 -1.21248

LOC680290 Similar to Zinc finger protein 2080.0012607 -1.7195 0.000211 -2.04053 0.850874 -1.02191 0.122257 -1.21269

LOC305633 similar to Antxr2 protein4.71E-05 2.84315 0.000682 2.02769 0.30417 1.15596 0.181687 -1.21299

Nap1l2 nucleosome assembly protein 1-like 20.0005229 -3.01004 0.001435 -2.55831 0.109003 -1.42787 0.355764 -1.21359

Ednra endothelin receptor type A0.0004407 5.32582 0.001488 3.97802 0.746262 1.10278 0.525342 -1.21403

PIAS1 protein inhibitor of activated STAT, 10.0001075 -2.19543 7.97E-05 -2.27167 0.189259 -1.17364 0.119914 -1.2144


LOC362795 immunoglobulin G heavy chain0.0155023 2.32052 0.091068 1.69501 0.675017 1.12699 0.499049 -1.21477

Dapk1 death associated protein kinase 14.16E-07 -3.05071 2.64E-07 -3.26245 0.128036 -1.13594 0.032055 -1.21479

Wdpcp WD repeat containing planar cell polarity effector0.0005582 -2.14302 0.016157 -1.52042 0.00456 -1.71234 0.196093 -1.21487

Tctex1d2 Tctex1 domain containing 20.0008602 -1.86063 0.000311 -2.06599 0.473414 -1.09469 0.143275 -1.21551

Dhx32 DEAH (Asp-Glu-Ala-His) box polypeptide 325.29E-06 2.38662 3.06E-06 2.54751 0.012782 -1.29771 0.043702 -1.21575

Nexn nexilin (F actin binding protein)9.92E-05 2.5168 0.000861 1.95127 0.66238 1.06045 0.16893 -1.2163

Chdh choline dehydrogenase0.0066551 -1.96343 0.000999 -2.5506 0.732238 1.06802 0.322448 -1.21632

LOC498222 similar to specifically androgen-regulated protein1.70E-06 -1.92329 2.24E-07 -2.34153 0.98896 1.00076 0.005986 -1.21654

RGD1306962similar to dJ55C23.6 gene product0.0034456 2.12702 0.001883 2.31003 0.168453 -1.32158 0.317575 -1.21688

Psme4 proteasome (prosome, macropain) activator subunit 48.82E-06 -1.91699 3.94E-06 -2.06384 0.097895 -1.13036 0.017024 -1.21696

Dnase2a deoxyribonuclease II alpha9.56E-06 -1.82256 1.52E-06 -2.15015 0.620341 -1.03192 0.012138 -1.2174

LOC499806 Similar to RIKEN cDNA 4933404M020.0009029 -4.28528 0.000283 -5.68985 0.767898 1.09059 0.507996 -1.21748

LOC361346 Similar to chromosome 18 open reading frame 547.58E-05 5.02983 7.77E-05 5.00124 0.405716 -1.211 0.39251 -1.21792

Fyco1 FYVE and coiled-coil domain containing 19.78E-06 -1.93636 4.64E-06 -2.07485 0.093082 -1.13698 0.018945 -1.2183

Myo1b myosin Ib 7.80E-07 5.92759 5.70E-07 6.38171 0.070292 -1.31171 0.167108 -1.21837

Ankrd50 ankyrin repeat domain 501.22E-05 2.72449 3.85E-05 2.35462 0.636354 -1.05305 0.097133 -1.21846

Ephx1 epoxide hydrolase 1, microsomal5.85E-05 -3.38833 6.51E-05 -3.32732 0.21074 -1.24135 0.247936 -1.219

Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 25.45E-05 -2.11066 1.19E-05 -2.50885 0.797529 -1.02587 0.073364 -1.21941

Il1r2 interleukin 1 receptor, type II2.89E-05 18.1195 0.000173 9.49566 0.226903 1.56481 0.577919 -1.21944

of 148Diabetes

PAK3 p21 protein (Cdc42/Rac)-activated kinase 35.37E-05 2.16324 0.001915 1.56834 0.250563 1.13084 0.08038 -1.21974

Rabgap1 RAB GTPase activating protein 11.56E-05 -1.74702 2.16E-06 -2.06678 0.626162 -1.03114 0.011142 -1.21987

Glo1 glyoxalase 1 2.82E-06 -1.81837 8.32E-07 -2.0167 0.100495 -1.10064 0.004807 -1.2207

Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 27.52E-07 2.49983 7.58E-06 1.96629 0.561437 1.04117 0.017092 -1.22107

Itgav integrin, alpha V 9.94E-06 2.94129 0.000142 2.10854 0.262028 1.1422 0.10721 -1.22127

Pnkd paroxysmal nonkinesiogenic dyskinesia2.84E-05 -4.62933 1.41E-05 -5.39922 0.802279 -1.04782 0.298699 -1.22208

ARMCX3 armadillo repeat containing, X-linked 37.98E-07 6.38661 3.23E-06 4.68466 0.446481 1.11488 0.176861 -1.22283

Acbd5 Acyl-Coenzyme A binding domain containing 57.73E-05 -1.84317 1.68E-05 -2.12846 0.508458 -1.05898 0.041196 -1.2229

Phf17 PHD finger protein 17 1.07E-05 -3.18662 4.01E-06 -3.74816 0.750702 -1.0401 0.130197 -1.22339

Itga6 Integrin, alpha 6 2.87E-06 2.81801 5.75E-06 2.57279 0.252621 -1.11695 0.054765 -1.22341


Nr3c1 nuclear receptor subfamily 3, group C, member 19.33E-07 -2.61314 4.28E-07 -2.89356 0.200975 -1.10523 0.022735 -1.22384

Satb1 SATB homeobox 1 7.79E-08 -4.24205 9.27E-08 -4.10972 0.017447 -1.26405 0.032519 -1.22462

Gdpd2 glycerophosphodiester phosphodiesterase domain containing 20.0002968 -4.87462 0.001151 -3.61354 0.090027 -1.65279 0.458247 -1.22521

LOC378467 promethin 1.52E-05 3.48568 0.001607 1.8786 0.01532 1.51413 0.170738 -1.22543

Wnk1 WNK lysine deficient protein kinase 13.73E-05 2.35427 4.78E-05 2.28729 0.134106 -1.19071 0.088013 -1.22558

LOC683613 similar to Keratin, type II cytoskeletal 6G (Cytokeratin-6G) (CK 6G) (K6g keratin) (Keratin-K6irs) (mK6irs1/Krt2-6g)1.51E-06 4.22483 3.84E-06 3.57855 0.751868 -1.03826 0.113934 -1.22577

Fam3d family with sequence similarity 3, member D0.111216 -1.2808 0.314643 1.15988 0.002487 -1.82149 0.178577 -1.22611

Prkd3 protein kinase D3 2.64E-05 2.01849 0.000126 1.75827 0.444245 -1.06811 0.037509 -1.22618

Plagl1 pleiomorphic adenoma gene-like 10.0040975 2.19597 0.020717 1.7662 0.945995 1.01393 0.333004 -1.22624

Stxbp5 Syntaxin binding protein 5 (tomosyn)6.36E-07 -1.96292 8.27E-08 -2.40257 0.967794 -1.002 0.00278 -1.22643

Csad cysteine sulfinic acid decarboxylase8.29E-09 -3.76548 2.06E-09 -4.85934 0.375515 1.05215 0.005472 -1.22653

Dpy19l1 dpy-19-like 1 (C. elegans)1.02E-06 4.58004 2.11E-06 3.98904 0.580625 -1.06848 0.113541 -1.22678

Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 93.04E-07 3.56722 9.32E-07 3.00562 0.694906 -1.03402 0.037558 -1.22722

Dapk2 death-associated kinase 21.35E-05 9.30692 3.84E-05 6.91352 0.707 1.09692 0.413572 -1.22724

Slc39a4 solute carrier family 39 (zinc transporter), member 40.0011394 -2.34544 0.001229 -2.32141 0.247997 -1.24006 0.269495 -1.22735

Fkbp1a FK506 binding protein 1a2.34E-07 4.17255 6.57E-07 3.49246 0.77004 -1.02738 0.050936 -1.22745

Casp6 caspase 6 1.02E-07 2.7588 3.29E-07 2.39519 0.295175 -1.06601 0.007016 -1.22784

RGD1305938similar to expressed sequence AW5498777.97E-06 -1.9653 2.52E-06 -2.19682 0.197956 -1.09862 0.015439 -1.22804

Fundc2 FUN14 domain containing 20.0040165 -1.32563 0.569233 -1.04284 0.000232 -1.56145 0.019597 -1.22835

Wdfy3 WD repeat and FYVE domain containing 36.31E-05 -1.52499 1.40E-06 -2.0225 0.206851 1.07926 0.005951 -1.22883

Sytl1 synaptotagmin-like 1 3.38E-07 -2.16359 1.01E-07 -2.46205 0.166204 -1.08011 0.003546 -1.2291

Nat8l N-acetyltransferase 8-like2.39E-07 16.1808 3.85E-07 13.7111 0.821134 -1.04162 0.270945 -1.22924


Ap1s2 adaptor-related protein complex 1, sigma 2 subunit4.88E-05 2.43808 0.000207 2.06497 0.729469 -1.04136 0.105241 -1.22952

of 148 Diabetes

Fzd8 frizzled homolog 8 (Drosophila)2.04E-07 -6.13575 1.46E-07 -6.64321 0.285655 -1.13594 0.100333 -1.22989

Ppap2a phosphatidic acid phosphatase type 2A3.66E-06 2.59334 2.73E-05 2.06972 0.834496 1.01857 0.041156 -1.23016


Slc7a4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 41.15E-05 -1.91941 7.60E-07 -2.54096 0.313064 1.07581 0.015672 -1.23054

Ces3 carboxylesterase 3 5.42E-06 -9.9517 4.27E-05 -5.67956 0.0075 -2.15647 0.36551 -1.23073

Irx4 iroquois homeobox 4 0.0010605 -2.97722 0.001899 -2.69615 0.197797 -1.35908 0.369683 -1.23077

Pde3b phosphodiesterase 3B, cGMP-inhibited0.000187 2.79196 0.001615 2.08783 0.613735 1.08641 0.224563 -1.23089

Fam176a family with sequence similarity 176, member A0.0508797 -1.33607 0.000141 -2.35303 0.021905 1.43077 0.138472 -1.23092

Aqp2 aquaporin 2 (collecting duct)0.0182053 -4.22204 0.529911 -1.37671 0.025883 -3.7769 0.680133 -1.23156

Nradd neurotrophin receptor associated death domain3.62E-06 4.60296 2.14E-05 3.32859 0.42017 1.12279 0.164903 -1.23162


Cd44 Cd44 molecule 1.30E-08 5.09187 5.32E-08 3.90096 0.434959 1.05958 0.018105 -1.23189

NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 212.52E-05 -2.08211 9.76E-06 -2.30281 0.240041 -1.11391 0.039651 -1.23198

Ankh Ankylosis, progressive homolog (mouse)0.0002483 -1.74027 2.08E-05 -2.19627 0.793374 1.02434 0.046659 -1.23204

Fam46a Family with sequence similarity 46, member A8.92E-07 -2.85376 9.57E-06 -2.15311 0.000234 -1.63352 0.027841 -1.23246

Pnpla3 patatin-like phospholipase domain containing 30.0175349 -1.65264 0.001223 -2.27544 0.529699 1.117 0.249539 -1.23263

Nxnl2 nucleoredoxin-like 2 0.201178 1.43434 0.057068 -1.77762 0.022975 2.0684 0.442566 -1.2327

Igfbp3 insulin-like growth factor binding protein 30.0001284 23.5302 0.00019 19.7652 0.94129 -1.03555 0.661016 -1.23281

Pou3f1 POU class 3 homeobox 10.0588927 -1.41821 0.421537 -1.14393 0.028106 -1.52922 0.222751 -1.23347

LOC688459 /// LOC688548hypothetical protein LOC688459 /// hypothetical protein LOC6885481.75E-08 22.1271 2.29E-08 19.9471 0.466748 -1.1121 0.169497 -1.23364

Tgm2 transglutaminase 2, C polypeptide0.128941 -1.62306 0.103228 1.69229 0.002738 -3.38915 0.483527 -1.2339

Ptprg Protein tyrosine phosphatase, receptor type, G8.80E-07 2.44843 1.09E-05 1.90147 0.53954 1.04349 0.013293 -1.23399

Ctf1 cardiotrophin 1 1.92E-05 -2.95262 1.87E-05 -2.96416 0.126037 -1.22923 0.120009 -1.23404

Scamp1 secretory carrier membrane protein 13.58E-06 -1.96671 3.87E-07 -2.46995 0.782626 1.01736 0.008166 -1.23445


LOC100362819autism susceptibility candidate 2-like3.89E-07 -3.89204 1.02E-06 -3.31901 0.003499 -1.44874 0.048076 -1.23544

Tprkb Tp53rk binding protein 7.91E-05 -2.07551 1.55E-05 -2.49561 0.788034 -1.02797 0.065173 -1.23604

Nrg1 neuregulin 1 4.48E-06 4.34083 6.09E-06 4.09292 0.288785 -1.16553 0.154522 -1.23613


Ash1l ash1 (absent, small, or homeotic)-like (Drosophila)0.0014341 -1.54686 3.61E-05 -2.12402 0.287745 1.1101 0.049054 -1.23693


RGD1562339RGD1562339 3.21E-07 -2.45935 7.35E-08 -2.96534 0.672229 -1.02606 0.006662 -1.23716

FAM120C family with sequence similarity 120C7.13E-07 -4.13136 1.53E-07 -5.63584 0.368106 1.10261 0.071287 -1.23721

Fcgbp Fc fragment of IgG binding protein /// similar to Fc fragment of IgG binding protein; I0.0346194 -2.71046 0.102836 -2.05929 0.24894 -1.62868 0.601939 -1.2374

Gpsm1 G-protein signaling modulator 1 (AGS3-like, C. elegans)0.700272 1.22051 0.204794 -1.99228 0.213138 1.96488 0.680766 -1.23753

of 148Diabetes

RNF141 ring finger protein 141 0.0001221 -1.85143 3.84E-05 -2.06463 0.274436 -1.11009 0.043337 -1.23792

Slc6a20 solute carrier family 6 (proline IMINO transporter), member 205.23E-08 9.88291 2.22E-07 6.7179 0.182557 1.18837 0.108718 -1.23794

Plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 13.89E-07 -2.34525 5.34E-08 -3.00181 0.574606 1.03385 0.005594 -1.23805

Dpp8 dipeptidylpeptidase 8 1.04E-06 -1.75854 1.07E-07 -2.13193 0.63558 -1.02131 0.001067 -1.23817

Tef thyrotrophic embryonic factor3.54E-06 -4.17903 1.72E-06 -4.8203 0.589768 -1.07412 0.130905 -1.23895


Dync2li1 dynein cytoplasmic 2 light intermediate chain 10.0002008 -1.90431 2.62E-05 -2.36066 0.997499 1.00032 0.064371 -1.23924

Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 30.0039483 2.43298 0.002023 2.71416 0.182993 -1.38269 0.362428 -1.23945

RGD1306063similar to HT021 8.81E-05 -1.85508 1.69E-05 -2.17465 0.528283 -1.0578 0.035593 -1.24003

F2r coagulation factor II (thrombin) receptor2.62E-06 9.08291 4.76E-06 7.68473 0.804751 -1.04943 0.28688 -1.24036

Tmem67 transmembrane protein 670.0007949 -1.69638 5.09E-05 -2.20727 0.651204 1.04861 0.06532 -1.24085

Pthlh parathyroid hormone-like hormone1.71E-07 17.2708 1.58E-07 17.7804 0.190138 -1.27751 0.242613 -1.2409

Larp1b La ribonucleoprotein domain family, member 1B1.33E-07 -4.22101 9.61E-08 -4.4864 0.10152 -1.16753 0.032722 -1.24093

Sox9 SRY-box containing gene 9 [0.0009884 2.09879 0.00474 1.76488 0.776692 -1.04401 0.178743 -1.24153

Neo1 neogenin homolog 1 (chicken)7.41E-06 -3.12601 3.53E-06 -3.51796 0.40473 -1.10345 0.089025 -1.24181

Tinagl1 tubulointerstitial nephritis antigen-like 10.0001944 7.40386 0.000457 5.82585 0.943052 1.02307 0.503309 -1.2422

KCTD15 potassium channel tetramerisation domain containing 150.0002614 -2.21286 0.000632 -2.00366 0.038797 -1.37245 0.128664 -1.24271

Ctps2 CTP synthase II 1.76E-05 -2.05511 6.51E-06 -2.27835 0.188204 -1.12113 0.025605 -1.24291

Rap1a RAP1A, member of RAS oncogene family0.0001442 -2.04935 0.000171 -2.01347 0.057581 -1.26531 0.074593 -1.24316

Gpr126 G protein-coupled receptor 1262.79E-07 8.28344 1.22E-06 5.73383 0.300216 1.16153 0.145274 -1.24376

Klf9 Kruppel-like factor 9 5.39E-05 -2.1726 5.36E-05 -2.17414 0.060969 -1.24314 0.060298 -1.24402

LOC690326 hypothetical protein LOC6903260.0308017 -2.74433 0.002033 -5.64986 0.227937 1.65489 0.586909 -1.24403

Leng1 leukocyte receptor cluster (LRC) member 10.0001601 -2.19464 4.18E-05 -2.58791 0.660476 -1.05535 0.101243 -1.24446

Tubb2b tubulin, beta 2b 5.23E-09 18.7581 1.52E-08 12.9414 0.214442 1.16459 0.088816 -1.24461

Prelid2 PRELI domain containing 24.85E-05 2.69759 0.000208 2.23965 0.800795 -1.03338 0.120254 -1.24467

Arse arylsulfatase E (chondrodysplasia punctata 1)2.40E-06 -2.06145 6.25E-07 -2.36776 0.225087 -1.08374 0.007196 -1.24477

Ebag9 estrogen receptor binding site associated, antigen, 96.62E-05 -2.29825 7.64E-05 -2.26058 0.064766 -1.26612 0.081746 -1.24537

ELOVL5 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)2.12E-05 2.06191 0.000101 1.78981 0.369333 -1.08104 0.027976 -1.24538

Arhgap8 Rho GTPase activating protein 81.72E-07 3.38596 2.84E-07 3.139 0.085529 -1.15461 0.017229 -1.24545

Fdxacb1 ferredoxin-fold anticodon binding domain containing 10.0009261 -1.90407 0.000148 -2.33823 0.913342 -1.01427 0.120047 -1.24555

Il4ra interleukin 4 receptor, alpha3.10E-06 2.09062 1.38E-05 1.82951 0.218253 -1.09002 0.009302 -1.24558

Iffo2 Intermediate filament family orphan 20.0002252 2.16085 0.007347 1.54324 0.365668 1.12379 0.108405 -1.24596

Rab3d RAB3D, member RAS oncogene family5.90E-06 -1.74469 9.18E-07 -2.0355 0.247291 -1.06841 0.003184 -1.2465

Rcn2 reticulocalbin 2, EF-hand calcium binding domain8.16E-08 3.3636 6.54E-07 2.53022 0.359923 1.06647 0.010458 -1.24652

Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform3.62E-06 -1.90432 5.58E-07 -2.27567 0.483437 -1.04316 0.004998 -1.24658

of 148 Diabetes

LOC689176 similar to transmembrane protein 644.49E-07 -6.54249 5.91E-07 -6.12807 0.055531 -1.33101 0.122543 -1.2467

Msi2 Musashi homolog 2 (Drosophila)0.0053069 -1.67144 0.000428 -2.1806 0.747014 1.04629 0.142106 -1.2469

Taf9b TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor0.0001318 -2.23404 0.00142 -1.74987 0.00417 -1.59242 0.096683 -1.24731

Itgav integrin, alpha V 8.38E-05 3.38168 0.00107 2.29852 0.351698 1.17941 0.221807 -1.24744

DHRS9 dehydrogenase/reductase (SDR family) member 90.0001213 8.6809 0.000421 6.04472 0.664626 1.15076 0.497894 -1.24797

Vcl vinculin 9.27E-07 2.42985 6.18E-06 1.99725 0.708377 -1.02604 0.010165 -1.24828

Eid1 EP300 interacting inhibitor of differentiation 15.50E-05 -2.02924 1.20E-05 -2.39105 0.544514 -1.0595 0.041262 -1.24841

LOC687508 similar to Cytochrome c oxidase polypeptide VIIa-heart, mitochondrial precursor (Cytoch3.65E-06 -3.3874 1.13E-06 -4.15136 0.869219 -1.01871 0.076281 -1.24847

Naa30 N(alpha)-acetyltransferase 30, NatC catalytic subunit2.70E-05 2.19662 5.37E-05 2.04511 0.140076 -1.1627 0.042215 -1.24884

Eif2c2 eukaryotic translation initiation factor 2C, 22.39E-06 3.25501 1.39E-05 2.54292 0.811064 1.02496 0.056506 -1.24886

A3galt2 alpha 1,3-galactosyltransferase 20.0003605 2.30165 0.000193 2.49468 0.064384 -1.3536 0.15422 -1.24886

Plscr1 phospholipid scramblase 10.0001715 3.07543 2.97E-05 4.21522 0.0135 -1.71256 0.227812 -1.24949

Srcap Snf2-related CREBBP activator protein4.95E-05 -1.66007 3.20E-06 -2.08356 0.946335 1.00449 0.008634 -1.2495

Fkbp14 FK506 binding protein 140.0072382 -1.48303 0.000232 -2.00297 0.503182 1.08033 0.077378 -1.25017

Tm9sf3 transmembrane 9 superfamily member 31.62E-07 -2.39805 9.60E-08 -2.54836 0.014254 -1.17672 0.002673 -1.25048

SP6 Sp6 transcription factor0.0007892 -2.19664 5.94E-05 -3.16569 0.373825 1.15213 0.174894 -1.25086

Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase0.0002343 -2.56893 0.001669 -2.00439 0.013621 -1.60326 0.17365 -1.25093

Ms4a11 membrane-spanning 4-domains, subfamily A, member 110.0014939 2.12717 0.015165 1.63518 0.81266 1.03991 0.198672 -1.25095

Hsdl2 hydroxysteroid dehydrogenase like 22.01E-05 -1.94588 6.72E-06 -2.1628 0.151688 -1.12579 0.017116 -1.2513

RGD1305938similar to expressed sequence AW5498774.13E-07 -2.3379 1.51E-07 -2.62786 0.09657 -1.11351 0.004363 -1.25162

Clca2 /// Clca4lchloride channel calcium activated 2 /// chloride channel calcium activated 4-like0.190142 -1.42947 0.010196 -2.30296 0.342596 1.28632 0.393449 -1.25245

Tmem53 transmembrane protein 533.92E-06 -2.35446 1.13E-06 -2.74072 0.370296 -1.07609 0.019425 -1.25262

Ppm1h protein phosphatase 1H (PP2C domain containing)0.0101363 -1.63321 0.192549 -1.23195 0.008563 -1.66075 0.162839 -1.25273

Pcyt1a phosphate cytidylyltransferase 1, choline, alpha0.0005199 -1.71494 4.64E-05 -2.15184 0.989182 1.00135 0.047749 -1.25307

Mri1 methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)6.01E-05 -1.85195 1.09E-05 -2.17806 0.449873 -1.06607 0.022898 -1.25379

Cmtm7 CKLF-like MARVEL transmembrane domain containing 72.65E-08 4.03678 5.96E-08 3.52234 0.210808 -1.09405 0.009042 -1.25384

Ptprc protein tyrosine phosphatase, receptor type, C0.0002318 3.96593 0.000124 4.51995 0.140737 -1.42944 0.330295 -1.25423

Mmp14 matrix metallopeptidase 14 (membrane-inserted)0.0032973 2.26662 0.004036 2.20215 0.347549 -1.2186 0.28587 -1.25428

Cox11 COX11 homolog, cytochrome c oxidase assembly protein (yeast)0.0026309 2.01506 0.007783 1.77717 0.552892 -1.1063 0.2021 -1.25439

Abhd2 abhydrolase domain containing 20.0007085 2.05699 0.000915 1.9992 0.180999 -1.21963 0.132332 -1.25489

Tpm1 tropomyosin 1, alpha 5.68E-06 5.509 3.96E-06 5.98865 0.090881 -1.36447 0.197513 -1.25519

Fam102b family with sequence similarity 102, member B0.00087 4.03045 0.017917 2.23168 0.215948 1.43815 0.424137 -1.25579

Tmem40 transmembrane protein 40 [1.30E-05 2.50441 7.11E-05 2.06811 0.715844 -1.03736 0.046992 -1.2562

Tmem40 transmembrane protein 40 [1.30E-05 2.50441 7.11E-05 2.06811 0.715844 -1.03736 0.046992 -1.2562

Gja4 gap junction protein, alpha 45.36E-05 7.96743 0.000162 5.89211 0.790499 1.07608 0.417009 -1.25662

of 148Diabetes

RGD1307493similar to membrane protein expressed in epithelial-like lung adenocarcinoma0.0004053 2.91856 0.012524 1.80732 0.211604 1.28499 0.251088 -1.25671

Rhobtb1 Rho-related BTB domain containing 10.0010594 2.47345 0.042577 1.54768 0.221547 1.2717 0.243067 -1.25672

Wasl Wiskott-Aldrich syndrome-like0.0015998 2.54104 0.001295 2.62601 0.226478 -1.29897 0.285116 -1.25694

Ddx25 DEAD (Asp-Glu-Ala-Asp) box polypeptide 250.0015729 -1.80188 0.000446 -2.05165 0.453968 -1.10398 0.106302 -1.25701

Ptpro protein tyrosine phosphatase, receptor type, O1.38E-08 -56.5204 1.63E-08 -51.9288 0.112413 -1.36831 0.229369 -1.25716

Zbtb7c zinc finger and BTB domain containing 7C3.84E-07 -2.77678 8.88E-08 -3.42903 0.796716 -1.01829 0.009829 -1.25748

Fgl2 fibrinogen-like 2 0.0006076 2.87177 0.002821 2.27347 0.982911 1.00429 0.269958 -1.25777

Slc25a45 solute carrier family 25, member 450.0082916 -1.53199 0.204121 -1.18457 0.004106 -1.62674 0.098011 -1.25783

SPRED3 sprouty-related, EVH1 domain containing 30.0003692 2.17251 0.025036 1.43739 0.201995 1.20123 0.119789 -1.25823

Ccdc113 coiled-coil domain containing 1131.06E-06 -2.10122 2.08E-07 -2.50087 0.351499 -1.05745 0.003568 -1.25857

Sms spermine synthase 5.00E-06 2.74667 1.44E-05 2.404 0.333707 -1.10169 0.040301 -1.25873

Mdfic MyoD family inhibitor domain containing5.73E-07 -2.38901 5.92E-08 -3.20756 0.325431 1.06611 0.005437 -1.25937

3-Mar membrane-associated ring finger (C3HC4) 30.0336666 -1.4491 0.000549 -2.23091 0.203199 1.22242 0.15017 -1.2594

Mapt microtubule-associated protein tau1.57E-06 -2.19336 4.39E-08 -3.47328 0.006594 1.25704 0.006278 -1.25973

Porcn porcupine homolog (Drosophila)0.0005193 2.00985 0.004597 1.62654 0.880147 -1.01965 0.101684 -1.25994

LOC100363266Hypothetical protein LOC1003632668.70E-06 -1.60113 1.13E-07 -2.29064 0.027709 1.1352 0.001197 -1.26025

Sult2b1 sulfotransferase family, cytosolic, 2B, member 12.57E-06 4.66904 1.96E-05 3.23661 0.334634 1.14454 0.116465 -1.2604

Uhrf1bp1l UHRF1 binding protein 1-like3.82E-07 2.25335 2.68E-06 1.87823 0.384939 -1.05098 0.00267 -1.26088

Ltbp1 latent transforming growth factor beta binding protein 12.29E-05 4.4458 4.84E-05 3.84221 0.627642 -1.08988 0.211144 -1.26109

Fermt2 fermitin family homolog 2 (Drosophila)1.02E-06 4.963 1.09E-06 4.89608 0.108881 -1.2442 0.091664 -1.2612

Larp1b La ribonucleoprotein domain family, member 1B1.20E-08 -2.63496 2.03E-09 -3.36123 0.795461 1.01117 0.000508 -1.26153

PELI1 pellino homolog 1 (Drosophila)0.0018008 -1.73446 0.000376 -2.0244 0.535515 -1.08094 0.08929 -1.26164

Rbks ribokinase 2.06E-06 -2.57701 7.99E-07 -2.91931 0.206707 -1.11387 0.018063 -1.26183

Ubtd2 ubiquitin domain containing 20.0003274 1.81854 6.99E-05 2.11279 0.005008 -1.46608 0.0482 -1.2619

LOC688823 similar to cell division cycle 20 homolog [0.0003801 -1.75518 7.14E-05 -2.0491 0.44146 -1.0809 0.041749 -1.26191


Arpp19 CAMP-regulated phosphoprotein 195.01E-06 2.06447 5.00E-06 2.06509 0.008589 -1.26325 0.008646 -1.26287

Nudt12 nudix (nucleoside diphosphate linked moiety X)-type motif 127.77E-07 -4.57523 3.60E-07 -5.36533 0.52071 -1.07741 0.068216 -1.26347

Hoga1 4-hydroxy-2-oxoglutarate aldolase 11.31E-06 3.19596 1.39E-06 3.16837 0.038037 -1.25277 0.032783 -1.26368

Nr1d2 nuclear receptor subfamily 1, group D, member 26.38E-05 -2.23868 3.32E-05 -2.41706 0.176697 -1.17045 0.058673 -1.26371

Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box)0.0016654 -1.55554 3.44E-05 -2.19764 0.27796 1.1172 0.038992 -1.26457

Kctd12 potassium channel tetramerisation domain containing 126.27E-05 3.82222 0.000348 2.84586 0.742387 1.06182 0.219231 -1.26488

ATP10D ATPase, class V, type 10D2.90E-06 2.09521 8.93E-06 1.89074 0.072599 -1.14172 0.006329 -1.26519

Spp1 secreted phosphoprotein 10.0370979 2.67429 0.13897 1.91027 0.80379 1.10646 0.566832 -1.26525

Pomgnt1 protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase9.04E-08 4.06435 1.69E-07 3.64835 0.138399 -1.13627 0.016134 -1.26583

of 148 Diabetes

Gopc golgi associated PDZ and coiled-coil motif containing6.12E-05 -1.79724 1.05E-05 -2.10961 0.353028 -1.07867 0.015296 -1.26615

Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper conta2.88E-06 2.22732 4.07E-05 1.75161 0.953023 1.00423 0.009325 -1.26624

Macrod1 MACRO domain containing 14.40E-08 -2.03289 4.75E-09 -2.56204 0.895895 -1.00485 0.000171 -1.26641

Rtn4 reticulon 4 1.49E-08 6.10787 6.06E-08 4.54212 0.473153 1.06175 0.017921 -1.26651

Stbd1 starch binding domain 1 7.66E-05 -2.1823 4.26E-05 -2.33273 0.145704 -1.1854 0.055139 -1.26711

Stx11 syntaxin 11 3.34E-05 3.08923 0.001003 1.98264 0.16683 1.22944 0.119267 -1.26735

Atp8b1 ATPase, Class I, type 8B, member 10.0001482 -2.35717 8.15E-05 -2.54479 0.243135 -1.17418 0.099751 -1.26763

PHACTR1 phosphatase and actin regulator 10.0488209 2.20358 0.173709 1.66241 0.899314 1.04546 0.50532 -1.2679

PGLYRP4 peptidoglycan recognition protein 42.41E-07 2.99875 7.59E-07 2.57839 0.244813 -1.09038 0.008743 -1.26815

Prss30 protease, serine, 30 0.0068115 -3.16202 0.092674 -1.83598 0.039645 -2.18423 0.476654 -1.26824

Akr1c12 aldo-keto reductase family 1, member C120.530814 -1.21829 0.841225 1.06436 0.13739 -1.64475 0.452977 -1.26841

Glul glutamate-ammonia ligase (glutamine synthetase)6.36E-06 -4.30368 1.75E-06 -5.64217 0.821448 1.03329 0.128506 -1.26877

Pls3 plastin 3 0.171325 1.56725 0.391629 -1.31098 0.145879 1.61877 0.448245 -1.26925

Cd320 CD320 molecule /// CD320 antigen-like1.96E-06 2.41458 9.10E-06 2.05252 0.325686 -1.07896 0.011102 -1.26929

Ly6c Ly6-C antigen 4.80E-05 -3.42078 1.63E-05 -4.16464 0.794798 -1.04278 0.164037 -1.26953

RT1-A2 /// RT1-A3 /// RT1-EC2RT1 class Ia, locus A2 /// RT1 class I, locus A3 /// RT1 class Ib, locus EC20.338854 1.3767 0.100314 1.79286 0.148305 -1.65338 0.469359 -1.2696

Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region7.38E-08 2.89698 5.83E-07 2.26082 0.878737 1.00908 0.003145 -1.26986

Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 33.17E-09 -8.26356 3.81E-09 -7.87292 0.005364 -1.33526 0.013609 -1.27214

Xpa xeroderma pigmentosum, complementation group A0.0002936 -2.21392 3.12E-05 -2.98718 0.664366 1.06057 0.102416 -1.27221

Areg amphiregulin 0.0011098 7.45906 0.003139 5.41125 0.848738 1.08312 0.568364 -1.27265

Fat4 FAT tumor suppressor homolog 4 (Drosophila)0.0004708 -6.84018 6.61E-05 -12.9466 0.275691 1.48708 0.497187 -1.27278

Npdc1 neural proliferation, differentiation and control, 12.08E-07 4.39573 1.58E-06 3.12438 0.307203 1.10457 0.029115 -1.27372

Serpinb9 Serpin peptidase inhibitor, clade B (ovalbumin), member 95.57E-07 3.96496 1.42E-06 3.38542 0.408094 -1.08772 0.036162 -1.27392

Cpa2 carboxypeptidase A2 (pancreatic)0.218893 -1.19925 0.439152 1.11725 0.004361 -1.70771 0.112753 -1.27453

Spats2l spermatogenesis associated, serine-rich 2-like1.48E-07 11.2652 1.74E-07 10.7165 0.213868 -1.21258 0.127525 -1.27467

Fkbp1a FK506 binding protein 1a1.76E-06 4.28326 3.21E-06 3.83423 0.296014 -1.14114 0.073845 -1.27478

RGD1308059similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed0.0001952 5.58886 0.000188 5.64271 0.37077 -1.28709 0.388322 -1.27481

Igsf7 /// LOC363715 /// RGD1561778immunoglobulin superfamily, member 7 /// similar to CLM3 /// similar to dendritic cell-0.0010897 2.76542 0.005432 2.16431 0.993086 1.00183 0.268468 -1.2754

Nupl1 nucleoporin like 1 0.0434183 -1.13011 0.163349 1.08149 2.37E-05 -1.55931 0.001404 -1.27581

LOC689176 similar to transmembrane protein 648.91E-05 -2.49541 0.000227 -2.22278 0.021508 -1.43324 0.089265 -1.27665

Tsr2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)8.16E-05 -2.41803 6.32E-05 -2.49756 0.116504 -1.23615 0.077059 -1.27681

Arih1 Ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)0.0064455 -1.47514 0.000135 -2.06536 0.411649 1.09649 0.050606 -1.2769

Rai14 retinoic acid induced 14 9.68E-09 5.48358 2.25E-07 3.12676 0.002073 1.37326 0.008701 -1.27708

Bace2 Beta-site APP-cleaving enzyme 26.85E-06 -2.7826 2.40E-06 -3.24073 0.377739 -1.0973 0.038918 -1.27796

Acss1 acyl-CoA synthetase short-chain family member 10.128236 -1.39381 0.722342 -1.07471 0.03254 -1.65742 0.24554 -1.27797

of 148Diabetes


Wasf1 WAS protein family, member 10.000266 -3.37177 5.28E-05 -4.63312 0.723234 1.07486 0.247258 -1.27839

Dennd5a DENN/MADD domain containing 5A5.75E-06 3.52581 1.55E-05 3.0118 0.482262 -1.09214 0.074036 -1.27853

Pfn2 profilin 2 0.0002209 2.22423 0.000416 2.06995 0.204572 -1.18995 0.086711 -1.27865

Slc38a4 solute carrier family 38, member 41.33E-07 6.67951 3.80E-08 9.28234 0.000816 -1.77691 0.056648 -1.27865


Soat1 sterol O-acyltransferase 12.52E-05 2.6513 0.000887 1.78708 0.225492 1.15996 0.06106 -1.279

Ptpla protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a3.00E-06 3.69015 1.13E-06 4.41173 0.005744 -1.52923 0.062327 -1.27911

Prodh proline dehydrogenase 2.46E-06 -2.51502 1.03E-06 -2.81101 0.122106 -1.14485 0.013583 -1.27958

CRADD CASP2 and RIPK1 domain containing adaptor with death domain0.0022335 -1.66398 0.000208 -2.0919 0.881583 -1.01789 0.064852 -1.27965

Adam15 a disintegrin and metallopeptidase domain 15 (metargidin)0.0001039 -2.07926 6.85E-06 -2.89726 0.436941 1.08826 0.043777 -1.28041

Dennd3 DENN/MADD domain containing 37.19E-05 3.22175 0.000422 2.46903 0.906971 1.01909 0.153616 -1.28042

Fahd2a fumarylacetoacetate hydrolase domain containing 2A6.18E-06 -2.28295 3.20E-06 -2.46117 0.061157 -1.18798 0.014082 -1.28072

Car2 carbonic anhydrase II 1.71E-07 75.8534 2.42E-07 62.8474 0.824849 -1.06125 0.368837 -1.28087

Scarb2 scavenger receptor class B, member 21.71E-05 3.20539 2.20E-05 3.08381 0.140985 -1.23268 0.088955 -1.28128

RGD1563982similar to F-box only protein 270.0002489 2.48453 0.000452 2.29841 0.277167 -1.18545 0.127592 -1.28145

Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)1.48E-06 3.10836 4.48E-06 2.66624 0.32404 -1.09927 0.024895 -1.28155

LOC100364854 /// LOC290071similar to RIKEN cDNA A430107P09 gene-like /// similar to RIKEN cDNA A430107P09 gene2.02E-05 3.66936 1.30E-05 3.97315 0.054979 -1.38824 0.127401 -1.2821

Tle1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.0217709 1.60144 0.001219 2.24645 0.007604 -1.79852 0.172143 -1.28213

Acaa2 acetyl-Coenzyme A acyltransferase 20.0107207 -2.6008 0.12031 -1.65243 0.04118 -2.01799 0.414659 -1.28214

Map7d1 MAP7 domain containing 14.61E-07 3.27461 1.72E-05 2.0872 0.037592 1.22313 0.0152 -1.28269

Ccs copper chaperone for superoxide dismutase8.74E-07 -1.67559 5.43E-08 -2.0909 0.490944 -1.028 0.000186 -1.2828

Pigx phosphatidylinositol glycan anchor biosynthesis, class X1.39E-06 -2.81077 6.44E-07 -3.13502 0.122484 -1.15092 0.015396 -1.28369


Myh10 myosin, heavy chain 10, non-muscle1.64E-05 2.07994 2.52E-05 1.99582 0.031108 -1.23245 0.014098 -1.2844

LOC679869 Similar to transcription factor 7-like 2, T-cell specific, HMG-box0.0013439 -1.86671 0.000237 -2.26096 0.662637 -1.06058 0.08993 -1.28457

Ppp1r13b protein phosphatase 1, regulatory (inhibitor) subunit 13B4.02E-06 -2.03612 5.38E-07 -2.52176 0.583574 -1.03746 0.004585 -1.2849

Mapt microtubule-associated protein tau6.29E-07 -2.23143 1.43E-08 -3.67612 0.002416 1.28211 0.002294 -1.28493


Vps54 vacuolar protein sorting 54 homolog (S. cerevisiae)1.62E-05 -1.88885 2.40E-06 -2.27094 0.364169 -1.06902 0.006806 -1.28527

Cndp1 carnosine dipeptidase 1 (metallopeptidase M20 family)0.104418 -1.23158 0.673131 1.05105 0.002063 -1.66402 0.058256 -1.2855

Acyp2 acylphosphatase 2, muscle type0.0006122 -1.50263 0.05262 -1.18532 0.000182 -1.62991 0.009924 -1.28572

Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon isoform9.18E-06 -1.98133 2.37E-06 -2.26628 0.128422 -1.12429 0.006587 -1.28598

Pcif1 PDX1 C-terminal inhibiting factor 11.17E-05 -3.82302 5.42E-05 -2.96356 0.006815 -1.65896 0.110018 -1.28601

Pank2/Rnf24 pantothenate kinase 2 [0.0003996 2.9449 0.001792 2.34408 0.902152 -1.02386 0.212496 -1.28629

of 148 Diabetes

Pank2/Rnf24 pantothenate kinase 2 [0.0003996 2.9449 0.001792 2.34408 0.902152 -1.02386 0.212496 -1.28629

Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.0001199 2.00212 0.000504 1.75312 0.268325 -1.12641 0.035992 -1.28639

LOC246295 glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein8.30E-05 -1.92315 1.73E-05 -2.25434 0.322453 -1.09892 0.022126 -1.28817

Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 13.79E-06 3.75804 8.82E-05 2.36766 0.117443 1.23198 0.065712 -1.28837

Hspc159 galectin-related protein0.0018265 -1.64567 5.24E-05 -2.3401 0.392734 1.10349 0.048457 -1.28862

RT1-Da RT1 class II, locus Da 6.93E-06 21.9584 5.88E-06 23.522 0.314184 -1.38113 0.422585 -1.28932

Inadl InaD-like (Drosophila) 3.47E-06 -1.72229 1.58E-07 -2.25254 0.779791 1.01406 0.000754 -1.28975

Opn3 opsin 3 0.0001909 2.83998 0.002443 2.01403 0.594786 1.09323 0.152408 -1.28984

Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)2.29E-08 25.5484 3.62E-08 21.2719 0.648019 -1.07404 0.129401 -1.28996

Klhl7 kelch-like 7 (Drosophila) 9.99E-05 -2.51884 2.54E-05 -3.05934 0.654355 -1.06218 0.085209 -1.2901

GADL1 glutamate decarboxylase-like 10.241426 -2.10276 0.750454 -1.21337 0.208012 -2.23588 0.67597 -1.29019

Egf epidermal growth factor0.0001427 -3.39517 7.14E-05 -3.85474 0.49865 -1.13659 0.195823 -1.29044


Hibadh 3-hydroxyisobutyrate dehydrogenase1.31E-06 -2.80694 5.61E-07 -3.16555 0.133139 -1.14431 0.013343 -1.2905

Asam adipocyte-specific adhesion molecule0.0014588 2.086 0.031051 1.49911 0.643054 1.0775 0.137637 -1.2914


Map4k4 mitogen-activated protein kinase kinase kinase kinase 41.22E-06 3.45187 5.54E-06 2.76176 0.737301 -1.03389 0.028281 -1.29224

Paip2 poly(A) binding protein interacting protein 24.60E-05 -1.80004 3.78E-06 -2.27952 0.789845 -1.0206 0.008481 -1.29246

Phf17 PHD finger protein 17 0.0001256 -1.91062 1.51E-05 -2.38532 0.718726 -1.03568 0.025637 -1.29299

Wbp1 WW domain binding protein 13.62E-07 -2.59136 5.05E-08 -3.40555 0.803318 1.01634 0.003526 -1.29306

Ap3b2 adaptor-related protein complex 3, beta 2 subunit0.0001078 2.95683 0.001448 2.07677 0.550911 1.10055 0.132832 -1.29368

Bace2 beta-site APP-cleaving enzyme 22.01E-07 -2.46684 1.54E-07 -2.54539 0.003478 -1.2542 0.001628 -1.29414

Arhgef3 Rho guanine nucleotide exchange factor (GEF) 32.51E-08 -2.75529 2.77E-09 -3.81847 0.190005 1.07063 0.000634 -1.29444

Krt78 keratin 78 0.0040882 -1.86818 0.000107 -3.02982 0.189885 1.25258 0.138964 -1.29476

Bex1 brain expressed gene 10.0005814 2.20667 0.003043 1.82942 0.636192 -1.07346 0.110936 -1.29482

Trio triple functional domain (PTPRF interacting)1.90E-06 2.74808 4.06E-05 1.95437 0.349371 1.08591 0.014304 -1.29488

Fam115a family with sequence similarity 115, member A0.0004371 2.81805 0.003663 2.08037 0.809978 1.04593 0.190283 -1.2951

LOC100910973uncharacterized LOC1009109730.053123 3.24855 0.006534 6.65017 0.097208 -2.65367 0.630965 -1.29629

Clvs1 Clavesin 1 1.86E-06 -4.72032 7.83E-07 -5.68232 0.574302 -1.07718 0.074906 -1.29671

Vof16 ischemia related factor vof-160.0016943 2.86075 0.070981 1.60441 0.199694 1.37374 0.284104 -1.29796

Gls2 glutaminase 2 (liver, mitochondrial)3.35E-05 2.08534 0.008193 1.36222 0.099939 1.17906 0.018471 -1.29837

Kif16b kinesin family member 16B1.70E-05 -1.92004 5.54E-06 -2.13433 0.061732 -1.16822 0.006511 -1.2986

Prkx protein kinase, X-linked 0.000308 2.18273 0.004779 1.64724 0.880424 1.02026 0.077565 -1.29877

Adfp Adipose differentiation related protein0.0001155 4.34943 0.000869 2.96372 0.578154 1.12992 0.249933 -1.29881

Ptprj protein tyrosine phosphatase, receptor type, J1.52E-05 -4.00491 4.74E-06 -5.06112 0.859107 -1.02789 0.119478 -1.29898

of 148Diabetes

Ptpn3 Protein tyrosine phosphatase, non-receptor type 39.16E-05 -1.58164 1.74E-06 -2.19142 0.340209 1.06661 0.003373 -1.29901

Phkb Phosphorylase kinase, beta1.13E-05 -2.43973 2.51E-06 -2.97286 0.507058 -1.06649 0.022267 -1.29953

Cyhr1 Cysteine and histidine rich 10.0005211 -1.71737 4.62E-05 -2.15762 0.735903 -1.03442 0.026871 -1.29959

Akap7 A kinase (PRKA) anchor protein 77.73E-06 -2.58841 9.57E-07 -3.49793 0.689745 1.03965 0.023475 -1.29985

RGD1310552similar to hypothetical protein MGC389600.0034016 -2.16684 0.001394 -2.45824 0.490355 -1.14577 0.20107 -1.29986

VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)0.0062848 -1.47654 0.068852 -1.24971 0.003699 -1.53639 0.038394 -1.30036

Slc6a14 solute carrier family 6 (neurotransmitter transporter), member 142.52E-06 5.60877 5.72E-06 4.70029 0.573332 -1.09001 0.111114 -1.30069


Crot carnitine O-octanoyltransferase0.0003186 -2.41785 0.001142 -2.06387 0.020715 -1.52485 0.110324 -1.30161

Hipk3 homeodomain interacting protein kinase 35.72E-07 2.2331 7.20E-06 1.7792 0.531172 -1.03758 0.00157 -1.30228

Cdh13 cadherin 13 0.0017726 -1.75414 4.34E-05 -2.66399 0.245356 1.1658 0.062683 -1.30271

St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 40.0019441 -2.0656 0.000875 -2.28419 0.336612 -1.17818 0.137707 -1.30285

RGD1305254similar to transmembrane protein 23.18E-05 3.10991 0.000684 2.06762 0.320785 1.15447 0.087073 -1.30286


Homer1 homer homolog 1 (Drosophila)0.0002381 2.14803 6.76E-05 2.50005 0.009002 -1.51771 0.060861 -1.30401

Vash2 vasohibin 2 3.99E-05 2.72462 0.003339 1.66515 0.104197 1.25453 0.064069 -1.30428

Kcnk4 potassium channel, subfamily K, member 40.0009913 -2.0889 0.000142 -2.68455 0.92094 -1.01506 0.105971 -1.3045

Cux1 cut-like homeobox 1 4.78E-05 -1.76492 4.52E-06 -2.18597 0.491105 -1.05326 0.006071 -1.30453

Glul glutamate-ammonia ligase (glutamine synthetase)1.99E-05 -3.47241 3.48E-06 -4.81756 0.672301 1.06323 0.093215 -1.30488

Vkorc1 vitamin K epoxide reductase complex, subunit 11.23E-05 -1.9769 2.02E-06 -2.37915 0.291685 -1.08426 0.00593 -1.30488

Tshz1 teashirt zinc finger homeobox 11.27E-05 -2.00547 4.79E-07 -2.91975 0.175549 1.11537 0.00672 -1.3053

Amph amphiphysin 6.69E-05 2.04226 0.006465 1.41354 0.316966 1.10641 0.022612 -1.30583

Trib2 tribbles homolog 2 (Drosophila)1.06E-05 -2.86453 4.76E-06 -3.22616 0.209149 -1.15964 0.039184 -1.30604

Pcdh21 protocadherin 21 0.0004533 2.05597 0.023445 1.42341 0.449353 1.10576 0.067503 -1.30624

Plek pleckstrin 1.15E-05 3.24255 6.99E-05 2.50476 0.941269 -1.00936 0.060646 -1.30668

Me1 malic enzyme 1, NADP(+)-dependent, cytosolic2.90E-06 3.65943 3.90E-06 3.48078 0.08901 -1.24316 0.044537 -1.30696

Dmkn dermokine 1.10E-06 38.2199 3.61E-06 22.6089 0.382471 1.29327 0.364043 -1.30713

Lpin2 lipin 2 0.0174139 -1.4361 0.000425 -2.00891 0.591189 1.07013 0.058012 -1.30719

Sdr42e1 short chain dehydrogenase/reductase family 42E, member 10.233134 -1.54938 0.748899 -1.11905 0.118649 -1.8099 0.452764 -1.30721

Stk32c serine/threonine kinase 32C1.20E-06 -6.4558 6.28E-07 -7.60925 0.492655 -1.10917 0.1 -1.30734

Tep1 telomerase associated protein 10.595495 -1.11277 0.006371 -2.03001 0.123424 1.39483 0.202349 -1.30789

Arl15 ADP-ribosylation factor-like 158.71E-05 -2.2063 3.02E-06 -3.48978 0.119521 1.20916 0.039024 -1.30813

Wnk4 WNK lysine deficient protein kinase 47.87E-07 -3.98705 2.13E-07 -5.1426 0.887665 -1.01486 0.0287 -1.30899

Wnt16 wingless-type MMTV integration site family, member 162.54E-05 -5.22434 2.05E-06 -10.1289 0.074782 1.48107 0.197948 -1.30904

LOC100365715rCG31761-like 0.0001348 -1.90576 3.73E-05 -2.16637 0.172943 -1.15194 0.021408 -1.30946

of 148 Diabetes

LOC678772 similar to O-acetyltransferase8.81E-06 -2.98779 4.67E-06 -3.291 0.152523 -1.18995 0.039334 -1.31071

Cdh13 cadherin 13 0.0031147 -1.63127 3.34E-05 -2.64778 0.106008 1.23821 0.049875 -1.31087

Klhl21 kelch-like 21 (Drosophila)0.0151212 -1.51497 0.000723 -2.04543 0.834318 1.02958 0.079312 -1.31136

Klk8 kallikrein related-peptidase 81.68E-05 7.20973 3.18E-05 6.11364 0.637093 -1.11204 0.246052 -1.31141

Pcsk6 proprotein convertase subtilisin/kexin type 63.66E-06 -7.54553 9.86E-07 -11.0195 0.568095 1.11355 0.171791 -1.31148

Amt aminomethyltransferase1.06E-08 -3.70646 5.05E-09 -4.21816 0.033107 -1.15256 0.001177 -1.31168

Ccdc28b coiled coil domain containing 28B0.0013177 -1.79374 0.000138 -2.27972 0.798722 -1.03246 0.055232 -1.31218

RGD1566399similar to MYST histone acetyltransferase monocytic leukemia 47.79E-05 -2.15927 4.80E-05 -2.27944 0.070367 -1.24328 0.031333 -1.31248

Kiaa0895l hypothetical protein LOC6887360.0007705 2.59493 0.012543 1.78869 0.596445 1.10525 0.172368 -1.31258

Znf292 zinc finger protein 292 0.0019531 -1.54593 8.43E-05 -2.0203 0.964703 -1.00441 0.022436 -1.31262

Fam105a family with sequence similarity 105, member A0.0004928 2.42765 0.00077 2.28792 0.213255 -1.23744 0.12214 -1.31301

Elmod3 ELMO/CED-12 domain containing 30.0178739 -1.53344 0.001117 -2.03991 0.936818 1.01184 0.093846 -1.31472

Sulf2 sulfatase 2 2.79E-06 -2.95518 5.29E-06 -2.7065 0.004703 -1.43659 0.018843 -1.3157

Gpcpd1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)0.0001906 -2.96931 0.000103 -3.28343 0.329767 -1.19014 0.140244 -1.31604

H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)0.906471 -1.01963 0.102132 1.34424 0.006214 -1.8038 0.124963 -1.31605

Spop speckle-type POZ protein7.39E-05 -2.0516 0.000105 -1.9806 0.012441 -1.3638 0.02165 -1.3166

Schip1 schwannomin interacting protein 11.82E-05 2.91973 3.00E-05 2.72075 0.12338 -1.22694 0.04921 -1.31668

Aldh2 aldehyde dehydrogenase 2 family (mitochondrial)0.000263 -1.71583 0.002803 -1.44882 0.000937 -1.55967 0.013489 -1.31696

Cd44 Cd44 molecule 8.25E-09 7.79723 2.32E-08 6.06008 0.787846 -1.02361 0.011122 -1.31703

LOC691143 Similar to Serum amyloid A-3 protein precursor0.0033704 2.04323 0.067001 1.44467 0.693005 1.07368 0.151254 -1.31725

LOC100912085late cornified envelope protein 3C-like0.0144792 47.1032 0.018442 38.6765 0.950981 -1.08178 0.829518 -1.31748

Nnmt nicotinamide N-methyltransferase4.51E-06 3.07165 4.71E-05 2.26253 0.780483 1.03018 0.02811 -1.31785

Gch1 GTP cyclohydrolase 1 5.16E-06 5.42855 2.09E-05 4.06096 0.9314 1.01416 0.119174 -1.3181

CDADC1 cytidine and dCMP deaminase domain containing 13.32E-05 -1.77385 9.69E-07 -2.50452 0.349357 1.07096 0.003909 -1.31837

Ttc17 tetratricopeptide repeat domain 173.62E-05 -1.73674 2.06E-06 -2.25037 0.800412 -1.01772 0.003364 -1.31871

Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 12.08E-06 -3.42935 1.27E-06 -3.72461 0.094265 -1.21427 0.026849 -1.31881

LOC100363310hypothetical protein LOC1003633109.57E-06 3.76503 3.12E-06 4.66053 0.006598 -1.63276 0.073899 -1.31903

LOC100910885apolipoprotein L3-like 1.37E-05 -1.92152 4.13E-06 -2.15193 0.046434 -1.17804 0.004062 -1.31931

Lrtomt leucine rich transmembrane and 0-methyltransferase domain containing0.0002379 -2.20967 5.92E-05 -2.63283 0.442127 -1.10748 0.059326 -1.31957

Fah fumarylacetoacetate hydrolase1.23E-06 -3.0967 5.30E-07 -3.52801 0.130545 -1.15899 0.013125 -1.32042

Cth cystathionase (cystathionine gamma-lyase)0.0005589 2.27315 0.29489 1.18136 0.035177 1.45707 0.098404 -1.32058

Gk glycerol kinase 9.65E-08 -2.2887 1.45E-08 -2.86908 0.287058 -1.05412 0.000312 -1.32143

Car5b carbonic anhydrase 5b, mitochondrial7.75E-05 -2.16421 4.25E-06 -3.14731 0.388251 1.10011 0.028423 -1.32191

Ddah1 dimethylarginine dimethylaminohydrolase 10.0014761 2.83918 0.693079 -1.09442 0.004703 2.34997 0.240755 -1.32225

Zc3h12a zinc finger CCCH type containing 12A0.0934669 1.38952 0.008478 1.82064 0.012985 -1.73269 0.144549 -1.32239

of 148Diabetes

Slc30a4 solute carrier family 30 (zinc transporter), member 44.67E-06 2.73807 1.08E-05 2.46218 0.098871 -1.18967 0.016849 -1.32297

Etv1 ets variant 1 0.0088144 -1.76495 0.001187 -2.24756 0.82164 -1.03922 0.128151 -1.32338

RGD1560248Similar to formin-like 2 isoform B3.45E-06 19.0225 4.51E-05 8.0161 0.05616 1.79192 0.313896 -1.32429

Fgd6 FYVE, RhoGEF and PH domain containing 60.0239588 1.49135 0.00592 1.70605 0.020206 -1.51529 0.086378 -1.32459

Dpp7 dipeptidylpeptidase 7 0.0011869 1.37579 0.000123 1.5677 0.000225 -1.50982 0.002525 -1.325

Il18 interleukin 18 0.0058672 -1.68079 0.000644 -2.12563 0.746053 -1.0479 0.078347 -1.32524

RGD1562717similar to ABI gene family, member 3 (NESH) binding protein7.81E-06 30.8262 1.13E-05 26.1079 0.742029 -1.12249 0.430184 -1.32535

Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit1.02E-05 2.68848 1.65E-05 2.52568 0.062176 -1.24557 0.023831 -1.32586

Fam115c Family with sequence similarity 115, member C0.0005128 -1.69703 4.09E-05 -2.14503 0.626126 -1.04904 0.01746 -1.32598

Prr12 Proline rich 12 2.79E-05 -2.17804 1.11E-05 -2.41576 0.085913 -1.1961 0.014872 -1.32665

Cobl cordon-bleu homolog (mouse)8.26E-06 -2.32093 1.02E-06 -3.03313 0.858824 -1.01553 0.009732 -1.32715

Ggct gamma-glutamyl cyclotransferase0.0002612 2.37392 0.002543 1.82784 0.878046 -1.02236 0.076718 -1.3278

Stx17 syntaxin 17 0.0562681 -1.42021 0.321857 -1.18067 0.017644 -1.59754 0.108895 -1.32809

Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)0.0879372 1.23343 0.002298 1.60754 0.000951 -1.73109 0.030235 -1.32823

Stau2 staufen, RNA binding protein, homolog 2 (Drosophila)6.29E-05 3.1266 0.001131 2.09823 0.46669 1.1214 0.094529 -1.32881

Hagh hydroxyacyl glutathione hydrolase0.0002101 -1.59642 5.05E-06 -2.18992 0.683033 1.03146 0.004555 -1.32992

Cav1 caveolin 1, caveolae protein2.81E-05 2.45047 0.000444 1.82734 0.939916 1.00823 0.026835 -1.33005

Itgb2 integrin, beta 2 0.0006595 2.21711 0.002263 1.91932 0.368241 -1.15147 0.089914 -1.33013

Cxcr7 chemokine (C-X-C motif) receptor 70.0002084 -1.97904 5.88E-05 -2.26632 0.196621 -1.16202 0.027925 -1.3307

Nradd neurotrophin receptor associated death domain8.03E-07 4.17307 2.03E-06 3.54529 0.274718 -1.13067 0.025882 -1.33088

Ildr1 immunoglobulin-like domain containing receptor 12.20E-06 -3.00709 1.24E-06 -3.2769 0.061628 -1.22139 0.014551 -1.33098

Fcgr1a Fc fragment of IgG, high affinity Ia, receptor (CD64)0.000772 3.54124 0.008509 2.3029 0.565851 1.15509 0.268737 -1.33127

Rbpms RNA binding protein with multiple splicing8.05E-05 3.95041 0.000405 2.96045 0.99193 1.00195 0.164198 -1.33179

Sepp1 selenoprotein P, plasma, 10.0003206 -2.07087 4.55E-05 -2.62165 0.686357 -1.05206 0.045594 -1.33187

Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans)0.0001434 2.04449 0.006198 1.47622 0.726091 1.03913 0.026409 -1.33279

Styxl1 serine/threonine/tyrosine interacting-like 12.07E-06 -3.98283 1.52E-06 -4.21243 0.078305 -1.2602 0.036541 -1.33285

Plxna2 plexin A2 2.88E-05 -2.31338 8.59E-07 -3.81416 0.064262 1.2366 0.019723 -1.33329

Abcg3l1 ATP-binding cassette, sub-family G (WHITE), member 3-like 10.0047719 2.27164 0.065014 1.5742 0.719162 1.08229 0.212352 -1.33333

Yipf1 Yip1 domain family, member 12.54E-05 -1.84592 7.00E-06 -2.07401 0.042567 -1.18682 0.003695 -1.33347

Cd53 Cd53 molecule 5.14E-05 12.6181 0.000121 9.44753 0.9991 1.00038 0.398614 -1.33509

Pros1 protein S (alpha) 4.67E-06 5.07536 1.53E-05 3.99636 0.747298 -1.05131 0.090149 -1.33515

Cnksr1 connector enhancer of kinase suppressor of Ras 10.000103 -1.78168 1.27E-05 -2.16422 0.277751 -1.09951 0.007486 -1.33559

Mpp5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)0.0126481 -1.66002 0.001586 -2.09883 0.737873 -1.05646 0.105189 -1.33572

Acsl1 acyl-CoA synthetase long-chain family member 10.0040845 -1.44583 4.87E-05 -2.0766 0.458696 1.07485 0.014102 -1.33624

Tmem164 transmembrane protein 1642.40E-05 -1.8055 9.40E-07 -2.48182 0.691486 1.02839 0.002739 -1.33665

of 148 Diabetes

LOC691849 hypothetical protein LOC6918490.0001346 -2.74731 4.17E-05 -3.29544 0.482945 -1.11512 0.085152 -1.3376

Slc34a2 solute carrier family 34 (sodium phosphate), member 20.0066822 2.13006 0.013501 1.92919 0.383256 -1.21184 0.199651 -1.33802

GLIPR2 GLI pathogenesis-related 20.0001982 3.30285 0.003186 2.159 0.490475 1.14322 0.15444 -1.33815

Ano6 anoctamin 6 3.23E-06 3.48933 1.25E-05 2.83855 0.461662 -1.0887 0.029206 -1.3383

Tmed3 transmembrane emp24 protein transport domain containing 32.02E-05 2.10616 0.000965 1.52912 0.744561 1.02866 0.00826 -1.33899

Ugt1a1 /// Ugt1a2 /// Ugt1a3 /// Ugt1a5 /// Ugt1a6 /// Ugt1a7c /// Ugt1a8 /// Ugt1a9UDP glucuronosyltransferase 1 family, polypeptide A1 /// UDP glucuronosyltransferase 1 0.0001217 3.83998 5.93E-05 4.43608 0.054809 -1.5477 0.170809 -1.33972

Large like-glycosyltransferase0.0002147 -2.14567 1.33E-05 -3.08717 0.570002 1.0735 0.040203 -1.34028

Esyt3 extended synaptotagmin-like protein 37.39E-06 -2.65949 1.96E-06 -3.20738 0.303227 -1.11142 0.015791 -1.34039

RGD1566036similar to RIKEN cDNA 2310008H040.0005685 -2.06636 0.000369 -2.17065 0.101177 -1.27639 0.056687 -1.34081

L2hgdh L-2-hydroxyglutarate dehydrogenase0.0089094 -1.96955 0.004296 -2.17665 0.352642 -1.21508 0.173717 -1.34284

Acvr1 activin A receptor, type I2.36E-05 2.97844 3.73E-05 2.78734 0.105797 -1.25672 0.046552 -1.34288

LOC688211 hypothetical protein LOC6882110.0002805 -1.49262 4.34E-06 -2.04362 0.777416 1.01929 0.001963 -1.34323

Ctr9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.0033605 -1.46206 4.79E-05 -2.07258 0.577333 1.05506 0.012599 -1.34359

Fam114a1 Family with sequence similarity 114, member A11.22E-05 3.1899 0.000519 1.97471 0.169109 1.2022 0.041546 -1.34368

Plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) mem0.0015028 -1.5843 7.03E-05 -2.07448 0.79687 -1.02629 0.016283 -1.34382

Pik3ap1 phosphoinositide-3-kinase adaptor protein 10.0010412 -1.92745 0.000404 -2.13881 0.182022 -1.21102 0.054083 -1.34382

Pdcd6ip programmed cell death 6 interacting protein4.09E-07 -1.72793 1.16E-08 -2.36716 0.625293 1.01884 4.15E-05 -1.34461

Rimklb ribosomal modification protein rimK-like family member B0.0358678 -1.51248 0.119641 -1.33132 0.032601 -1.5278 0.108955 -1.34481

LOC100361631hypothetical protein LOC1003616310.0007464 4.45328 3.65E-05 10.1741 0.004127 -3.07313 0.325241 -1.34513

Serpini1 serine (or cysteine) peptidase inhibitor, clade I, member 11.30E-05 -3.08077 7.08E-06 -3.38849 0.129409 -1.22308 0.037542 -1.34524

Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 33.58E-05 2.29509 0.000121 2.01307 0.140071 -1.17996 0.018833 -1.34526

Gls glutaminase 0.779289 -1.05175 0.001137 -2.36234 0.01857 1.66958 0.126742 -1.34531

Bmp3 bone morphogenetic protein 30.198066 1.35176 0.012412 1.99272 0.012825 -1.9834 0.204417 -1.34545

Sfrs3 splicing factor, arginine/serine-rich 31.19E-06 -2.34839 8.50E-08 -3.31952 0.475739 1.05054 0.001991 -1.34553

Ephb1 Eph receptor B1 2.34E-05 3.7405 0.000121 2.85217 0.868728 -1.02616 0.085288 -1.34576

LOC683788 Similar to Fascin (Singed-like protein)3.76E-05 2.61682 0.000268 2.06842 0.612114 -1.06409 0.035548 -1.34622

Epb4.1l1 erythrocyte protein band 4.1-like 18.86E-05 -1.8418 3.24E-05 -2.01944 0.040762 -1.22809 0.007744 -1.34653

Bst2 bone marrow stromal cell antigen 20.0325599 2.16756 0.213433 1.49951 0.819098 1.07341 0.349782 -1.34666

LOC100362005C10 protein 0.0019587 -1.51393 6.34E-05 -2.00824 0.873413 -1.01522 0.011847 -1.34669

Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.0002745 -1.73938 2.73E-05 -2.15682 0.382901 -1.08667 0.010658 -1.34746

Cd86 CD86 molecule 0.0259818 -2.02093 0.042232 -1.8644 0.180203 -1.46064 0.281074 -1.34751

Rassf5 Ras association (RalGDS/AF-6) domain family member 50.0007016 -1.85981 0.000132 -2.21688 0.322271 -1.13064 0.033441 -1.34771

MYO1B myosin IB 2.32E-05 2.90481 2.21E-05 2.92678 0.03671 -1.35793 0.040415 -1.34773

Ak3l1 adenylate kinase 3-like 12.93E-06 5.86382 2.30E-05 3.82677 0.430737 1.13593 0.08715 -1.34896

PVR poliovirus receptor 3.58E-05 5.24472 7.63E-05 4.44241 0.525332 -1.1432 0.175109 -1.34966

of 148Diabetes

Npl N-acetylneuraminate pyruvate lyase0.0009146 2.42268 0.047772 1.49797 0.326799 1.19811 0.1212 -1.34988

Trim6 tripartite motif-containing 60.001584 -1.94846 0.000578 -2.1884 0.232735 -1.20208 0.068333 -1.35011

Rnf114 ring finger protein 114 0.0014498 -1.57516 0.012172 -1.36141 0.001611 -1.56292 0.01376 -1.35082

Ndrg1 N-myc downstream regulated gene 11.56E-05 2.71964 0.002121 1.62265 0.082339 1.24069 0.024333 -1.3509

Evl Enah/Vasp-like 0.0135482 -1.50518 0.0004 -2.12525 0.742982 1.04502 0.048914 -1.35113

Dennd2d DENN/MADD domain containing 2D0.0008306 -1.76651 0.008969 -1.45615 0.001976 -1.63931 0.025171 -1.3513

Nid1 Nidogen 1 0.0048419 -4.24063 0.002737 -4.94728 0.704509 -1.15872 0.444418 -1.3518

Pfkm phosphofructokinase, muscle0.0005207 -1.47554 5.86E-06 -2.07977 0.569071 1.04224 0.002506 -1.35237

Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide0.0001735 2.01208 0.00056 1.79844 0.111448 -1.20944 0.021655 -1.35311

Plod1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 10.0010384 2.0967 0.012319 1.60817 0.807328 -1.03795 0.074795 -1.35325

Dcun1d4 DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)6.33E-05 -1.60588 2.23E-06 -2.10544 0.624183 -1.03228 0.001267 -1.3534

P4ha1 prolyl 4-hydroxylase, alpha polypeptide I0.0453332 2.0198 0.111081 1.7015 0.669941 -1.14029 0.33749 -1.35361

Slc12a5 solute carrier family 12 (potassium-chloride transporter), member 50.0026555 -2.09863 4.93E-05 -3.89439 0.105486 1.37079 0.117819 -1.35374

Pts 6-pyruvoyl-tetrahydropterin synthase9.15E-05 -3.28952 1.97E-05 -4.36772 0.906593 -1.0202 0.103379 -1.35459

Bnip3l BCL2/adenovirus E1B interacting protein 3-like9.09E-06 -1.95139 4.34E-07 -2.70885 0.727289 1.02467 0.002002 -1.35474

Rbm4b RNA binding motif protein 4B2.51E-05 -1.97742 4.59E-06 -2.35622 0.142678 -1.13698 0.004912 -1.35478

LOC690422 hypothetical protein LOC6904220.0261822 2.03146 0.063478 1.75185 0.565476 -1.16894 0.276411 -1.35551

LOC100360066rCG57228-like 0.0071671 -1.36422 3.77E-05 -2.02981 0.31567 1.09725 0.007933 -1.35601

Cspg4 chondroitin sulfate proteoglycan 40.646551 -1.12373 0.010012 -2.2739 0.140784 1.49224 0.248824 -1.35603

RGD1310507similar to RIKEN cDNA 1300017J021.52E-07 -3.13814 5.14E-08 -3.72033 0.082134 -1.14392 0.001996 -1.35614

Tshz1 teashirt zinc finger homeobox 10.0001623 -1.99489 3.80E-06 -3.18064 0.159648 1.17494 0.018828 -1.35701

DLG2 discs, large homolog 2 (Drosophila)0.0012193 -1.7687 0.000103 -2.28851 0.693755 -1.04884 0.030902 -1.35708

Ifngr1 interferon gamma receptor 11.02E-06 3.04446 6.41E-06 2.39801 0.451418 -1.06895 0.006732 -1.35712

S100a7a S100 calcium binding protein A7A3.87E-05 20.1378 0.000449 8.22356 0.148691 1.80355 0.431274 -1.35777

SVIP small VCP/p97-interacting protein0.0001562 -2.23594 6.02E-05 -2.51389 0.15539 -1.20805 0.03466 -1.35822

Msx2 msh homeobox 2 0.0003329 -2.54688 0.00017 -2.80871 0.219172 -1.232 0.085853 -1.35865

Cebpd CCAAT/enhancer binding protein (C/EBP), delta0.0004658 2.10288 0.000445 2.11362 0.04426 -1.36627 0.047033 -1.35932

Sgms1 sphingomyelin synthase 10.0022565 -1.71068 0.000221 -2.16608 0.575709 -1.07361 0.035693 -1.35941

Edem1 ER degradation enhancer, mannosidase alpha-like 14.93E-05 2.26697 4.26E-05 2.30565 0.014292 -1.38312 0.018301 -1.35991

Dnase1l2 deoxyribonuclease I-like 25.42E-06 -2.41097 2.48E-07 -3.7296 0.158885 1.13745 0.005962 -1.36

FNBP1L formin binding protein 1-like0.0030667 -1.62126 0.011643 -1.45617 0.007065 -1.51425 0.028708 -1.36005

Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A2.64E-05 -2.80409 3.63E-06 -3.84272 0.952568 1.00741 0.033676 -1.36032

Gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 22.86E-05 2.68306 0.000453 1.94168 0.900023 1.0152 0.02927 -1.36113


Irx3 iroquois homeobox 3 3.09E-06 4.39902 1.70E-05 3.25332 0.95568 -1.00746 0.044121 -1.36225

of 148 Diabetes

FRAS1 Fraser syndrome 1 0.0002123 -7.60301 0.000472 -6.0519 0.128961 -1.71212 0.358361 -1.36283

Wnt5b wingless-type MMTV integration site family, member 5B1.99E-06 3.05606 1.65E-05 2.32319 0.710795 -1.03607 0.009969 -1.36291

Peci /// RGD1310224peroxisomal D3,D2-enoyl-CoA isomerase /// similar to RIKEN cDNA 1810022C230.0002853 -2.12932 4.51E-05 -2.67705 0.525845 -1.08545 0.036105 -1.36466

Phyh Phytanoyl-CoA 2-hydroxylase0.14597 -1.42012 0.682915 -1.09668 0.03085 -1.76776 0.190827 -1.36514

MAP3K5 mitogen-activated protein kinase kinase kinase 50.0009641 -1.84315 0.000112 -2.32862 0.537705 -1.08073 0.032482 -1.36539

Kiaa0415 KIAA0415 protein 0.0044983 -1.42135 4.60E-05 -2.04358 0.581997 1.05297 0.008551 -1.36544

Stk17b serine/threonine kinase 17b1.52E-05 2.77333 2.68E-05 2.56982 0.064559 -1.26651 0.022043 -1.36681

Usp18 ubiquitin specific peptidase 180.0537043 -2.81773 0.206536 -1.87763 0.155476 -2.05187 0.514175 -1.36729

Gchfr GTP cyclohydrolase I feedback regulator3.14E-05 -2.31463 4.89E-06 -2.94198 0.484327 -1.07628 0.014106 -1.36799

Lxn latexin 1.59E-06 5.26787 5.94E-06 4.0402 0.726004 -1.04951 0.046229 -1.36842

Ypel5 yippee-like 5 (Drosophila)0.0002882 -1.84084 4.95E-05 -2.19441 0.203223 -1.14859 0.013738 -1.3692

Ptpn12 protein tyrosine phosphatase, non-receptor type 121.07E-06 4.03978 2.96E-06 3.39522 0.221981 -1.15116 0.018158 -1.3697

RGD1565496similar to Butyrate-induced transcript 10.0001747 2.11282 0.053789 1.29331 0.160303 1.19267 0.024537 -1.36975

Arhgef26 Rho guanine nucleotide exchange factor (GEF) 263.42E-07 -2.43493 3.22E-05 -1.62818 1.79E-06 -2.05068 0.000643 -1.37124

Wnt5a wingless-type MMTV integration site family, member 5A4.64E-06 2.94298 8.95E-05 2.0552 0.675222 1.04425 0.013185 -1.37129

Vps13c vacuolar protein sorting 13 homolog C0.0091559 -1.63446 0.000453 -2.27174 0.928387 1.01343 0.059393 -1.37148

Eci3 enoyl-Coenzyme A delta isomerase 31.85E-05 -1.97249 1.08E-06 -2.69112 0.945365 -1.00535 0.003044 -1.37163

Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase2.45E-05 -3.23539 6.95E-05 -2.76198 0.008068 -1.60717 0.047888 -1.37201

Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein8.57E-06 10.3928 1.99E-05 8.08461 0.787886 -1.0674 0.214066 -1.37215

Morc4 MORC family CW-type zinc finger 41.34E-05 4.09574 3.28E-05 3.48253 0.333073 -1.16699 0.067653 -1.37247

RGD1563692similar to hypothetical protein FLJ226710.148414 -1.42945 0.008857 -2.15526 0.686369 1.09808 0.193586 -1.37309

Tf transferrin 0.0007175 2.09876 0.004566 1.72251 0.415194 -1.1274 0.052477 -1.37366

Gsdmd gasdermin D 0.0004554 4.04082 0.003268 2.75605 0.798517 1.06682 0.230638 -1.37433

Ralgds ral guanine nucleotide dissociation stimulator3.01E-05 2.10561 0.016126 1.30797 0.113053 1.17033 0.00691 -1.37553

Crip cysteine-rich intestinal protein3.75E-05 18.4604 9.02E-05 13.1823 0.962336 1.01754 0.396997 -1.37625

Nox1 NADPH oxidase 1 9.76E-07 -6.13189 9.83E-06 -3.80775 0.000389 -2.21637 0.047237 -1.37631

Pfkp phosphofructokinase, platelet3.39E-05 12.0292 5.99E-05 9.95757 0.675267 -1.13942 0.318306 -1.37647

RGD1311595similar to KIAA2026 protein0.0029711 -1.6281 0.000329 -2.0009 0.356602 -1.12003 0.024771 -1.37649

Tes testis derived transcript 5.50E-07 3.66093 1.68E-06 3.07198 0.148731 -1.15574 0.007685 -1.37732

LOC688455 Hypothetical protein LOC6884550.0002844 2.44287 0.00601 1.71754 0.83362 1.0322 0.059435 -1.37793

Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide5.84E-05 2.58593 0.000589 1.96916 0.706663 -1.04943 0.031961 -1.37812

Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 30.0028934 -1.96705 0.000339 -2.59545 0.792178 -1.04458 0.080017 -1.37829

Col4a5 collagen, type IV, alpha 53.80E-05 2.04807 0.006563 1.37737 0.414273 1.07862 0.00647 -1.37856


regulator of G-protein signaling 17Rgs17 0.0001113 3.50586 0.000674 2.61087 0.882837 -1.02759 0.109585 -1.37984

of 148Diabetes

Scd stearoyl-CoA desaturase (delta-9-desaturase)0.0009737 -1.5437 0.011712 -1.32137 0.000528 -1.61245 0.005565 -1.38022

Lamc2 laminin, gamma 2 3.56E-07 16.3093 7.33E-07 12.7151 0.700434 -1.07624 0.11819 -1.38046

Zfyve20 zinc finger, FYVE domain containing 200.0014609 -1.84213 0.000156 -2.36394 0.58624 -1.07579 0.036781 -1.38053

Acer1 alkaline ceramidase 1 0.0105494 2.26577 0.157661 1.46829 0.663361 1.11778 0.226968 -1.38054

Pcgf3 polycomb group ring finger 32.56E-06 2.97362 6.84E-06 2.60316 0.075735 -1.20873 0.008431 -1.38075

Rdh10 retinol dehydrogenase 10 (all-trans)0.0003345 4.45447 0.00067 3.83284 0.509439 -1.18861 0.232732 -1.38139

LOC691170 Similar to zinc finger protein 84 (HPF2)0.0004081 -2.33689 9.50E-05 -2.85967 0.43198 -1.12888 0.058498 -1.38141

Gsta3 glutathione S-transferase A30.002615 -2.57614 0.001149 -2.95918 0.426046 -1.20266 0.180151 -1.38148

Csnk1g3 casein kinase 1, gamma 31.40E-05 -1.73211 1.57E-06 -2.08415 0.046628 -1.14814 0.000574 -1.3815


Lmbr1l limb region 1-like homolog (mouse)0.0009184 -2.1105 5.26E-05 -3.12518 0.651853 1.0709 0.05744 -1.38275

Csf1r colony stimulating factor 1 receptor0.0043288 2.42652 0.035131 1.76919 0.971782 -1.00826 0.188161 -1.38287

TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 16.01E-06 3.32779 1.07E-05 3.04157 0.075541 -1.2641 0.022341 -1.38306

Tef thyrotroph embryonic factor [8.05E-05 -3.09912 1.95E-05 -3.96154 0.620238 -1.08263 0.067971 -1.3839

C5orf41 chromosome 5 open reading frame 413.64E-06 -3.60159 2.40E-07 -6.20243 0.092583 1.24435 0.021863 -1.38396

Klhdc1 Kelch domain containing 10.0012725 -2.07862 0.000167 -2.71302 0.707597 -1.06041 0.063366 -1.38405

Tcp11l2 t-complex 11 (mouse) like 20.545276 -1.22821 0.054766 -2.07824 0.554276 1.22246 0.347092 -1.38417

Atp2c2 ATPase, Ca++ transporting, type 2C, member 27.27E-06 3.40597 0.001019 1.82819 0.038471 1.34577 0.026676 -1.38437

Rem2 RAS (RAD and GEM) like GTP binding 29.21E-06 2.01315 0.000599 1.47184 0.866794 -1.01233 0.001755 -1.38464

Vsnl1 visinin-like 1 7.96E-05 7.01749 0.000108 6.46695 0.382649 -1.27724 0.252885 -1.38597

Pion pigeon homolog (Drosophila)4.46E-05 5.89257 5.64E-05 5.56527 0.260486 -1.30901 0.180317 -1.386

Il17d interleukin 17D [Rattus norvegicus1.61E-05 2.21879 0.001065 1.54263 0.682038 1.0376 0.005545 -1.3862

Ccnd2 cyclin D2 8.74E-07 10.7351 6.04E-06 6.30358 0.276367 1.22816 0.100225 -1.38664

Hk2 Hexokinase 2 8.12E-06 2.33009 0.00045 1.61621 0.661168 1.03901 0.004576 -1.38758

Dguok deoxyguanosine kinase 2.07E-05 -2.88888 5.58E-06 -3.54595 0.334104 -1.13091 0.025449 -1.38813

Stradb STE20-related kinase adaptor beta0.0124315 -1.46884 0.000236 -2.12353 0.744498 1.04124 0.02546 -1.38845

Bnip3l BCL2/adenovirus E1B interacting protein 3-like4.24E-05 -1.54777 6.82E-07 -2.13325 0.89243 -1.00762 0.000309 -1.38878

Hint3 histidine triad nucleotide binding protein 31.09E-06 -2.13649 2.21E-07 -2.54305 0.028588 -1.16692 0.000469 -1.38898

Lyst lysosomal trafficking regulator0.003786 -1.66419 9.96E-05 -2.46045 0.640171 1.06331 0.031214 -1.39044

Sdc2 syndecan 2 6.44E-08 3.05133 9.31E-07 2.20602 0.928968 -1.00545 0.000523 -1.39073

Arrdc4 Arrestin domain containing 40.0248144 -1.66611 0.00018 -3.35824 0.080161 1.4491 0.112652 -1.39095

Tulp4 tubby like protein 4 0.0001007 -1.85957 2.16E-06 -2.84559 0.306377 1.09998 0.005348 -1.39115

Cetn4 centrin 4 2.01E-05 2.04154 0.000212 1.66921 0.146271 -1.13773 0.003345 -1.39151

LOC679692 Similar to lysophosphatidylglycerol acyltransferase 11.57E-07 2.38794 7.14E-07 2.04616 0.00926 -1.19262 0.00021 -1.39182

Blzf1 basic leucine zipper nuclear factor 10.0002899 -1.88326 5.32E-05 -2.24322 0.171564 -1.16868 0.012865 -1.39206

of 148 Diabetes


Mks1 Meckel syndrome, type 14.08E-06 -2.37347 1.19E-06 -2.76231 0.050327 -1.19779 0.00285 -1.39402

Prr15 proline rich 15 0.0034595 -2.22055 0.001796 -2.44151 0.257412 -1.26812 0.126321 -1.3943

USP15 ubiquitin specific peptidase 150.0002602 -1.71439 1.32E-05 -2.2697 0.563177 -1.05385 0.005026 -1.3952

Msn moesin 1.42E-05 2.12415 0.000137 1.73264 0.146697 -1.13852 0.003294 -1.39578

Otud7b OTU domain containing 7B0.0019789 -1.57865 5.48E-05 -2.19225 0.960854 -1.00514 0.010967 -1.39583

Wfdc2 WAP four-disulfide core domain 20.0001327 3.11168 0.001502 2.18945 0.916921 1.01803 0.079327 -1.39604

Mtus1 mitochondrial tumor suppressor 10.0021275 -1.75573 0.000124 -2.39344 0.852754 -1.02452 0.029549 -1.39665

Bik BCL2-interacting killer (apoptosis-inducing)0.0060418 -2.30828 0.004528 -2.41641 0.236322 -1.33568 0.17642 -1.39825



Tceal1 transcription elongation factor A (SII)-like 10.000875 -2.39274 0.001513 -2.22279 0.041917 -1.50657 0.082521 -1.39956

Ube2b ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.0020721 -1.6667 0.000124 -2.19958 0.618777 -1.06087 0.018504 -1.40006

Tmem106a transmembrane protein 106A1.11E-06 4.4939 1.69E-05 2.84706 0.327813 1.12714 0.018934 -1.40038

Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.0027182 2.30176 0.018628 1.77597 0.697171 -1.08193 0.12147 -1.40224

LOC500300 similar to hypothetical protein MGC68350.0009206 2.40193 0.047848 1.49245 0.445334 1.14763 0.084187 -1.40235

RT1-CE5 /// RT1-EC2RT1 class I, locus CE5 /// RT1 class Ib, locus EC20.0006656 3.07668 0.000369 3.42122 0.066267 -1.55955 0.144381 -1.4025

Dnajb3 DnaJ (Hsp40) homolog, subfamily B, member 31.57E-06 9.9954 4.65E-06 7.35195 0.869339 -1.03177 0.103375 -1.40275

Akap12 A kinase (PRKA) anchor protein 120.0004827 3.29052 0.017599 1.87471 0.318875 1.25125 0.147186 -1.40277

Lynx1 Ly6/neurotoxin 1 0.0003142 -2.07351 0.000343 -2.05401 0.020658 -1.41619 0.023294 -1.40288


Ankh ankylosis, progressive homolog (mouse)7.36E-06 -2.08998 5.17E-07 -2.8417 0.667558 -1.03277 0.001554 -1.40423

Rabgap1 RAB GTPase activating protein 10.0001221 -1.75526 5.72E-06 -2.35646 0.594799 -1.04607 0.003095 -1.40436

Srxn1 sulfiredoxin 1 homolog (S. cerevisiae)4.08E-06 2.66731 0.000131 1.83942 0.730238 1.03229 0.005094 -1.40473

Mkrn1 makorin ring finger protein 10.0002687 -2.03059 7.27E-05 -2.35237 0.130024 -1.21382 0.017922 -1.40617

Hs3st1 heparan sulfate (glucosamine) 3-O-sulfotransferase 18.48E-05 12.309 8.52E-05 12.2903 0.352868 -1.40452 0.35084 -1.40665

Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 41.18E-06 -3.34843 1.48E-07 -4.85434 0.758079 1.03013 0.006322 -1.40733

Gna14 guanine nucleotide binding protein, alpha 140.0032136 -2.28871 4.56E-05 -4.88962 0.069843 1.51803 0.1252 -1.40736

Krit1 KRIT1, ankyrin repeat containing0.105338 -1.26549 0.000446 -2.08994 0.250153 1.1734 0.029257 -1.40744

Cav1 caveolin 1, caveolae protein1.95E-05 2.76457 0.00022 2.06071 0.682535 -1.04946 0.016898 -1.40792

Fam126b family with sequence similarity 126, member B3.02E-06 -2.28711 5.57E-07 -2.80458 0.091685 -1.14815 0.001455 -1.40793

Gpr149 G protein-coupled receptor 1490.250619 -1.25971 0.624908 -1.0994 0.033347 -1.61331 0.103746 -1.40801

LOC363060 similar to RIKEN cDNA 1600029D217.11E-05 -2.0817 1.17E-05 -2.55947 0.203873 -1.14538 0.008204 -1.40826

RGD1563084Similar to FLJ20298 protein isoform a0.0212357 1.66043 0.006066 1.92732 0.024299 -1.63486 0.089716 -1.40847

Add3 adducin 3 (gamma) 0.0003711 -1.8457 1.49E-05 -2.62864 0.918779 1.01103 0.011088 -1.40866

of 148Diabetes

Pdlim7 PDZ and LIM domain 7 7.33E-07 6.94797 1.47E-06 5.87668 0.246523 -1.19195 0.040394 -1.40924

Mmp10 matrix metallopeptidase 100.0076884 9.71988 0.016698 6.95847 0.989132 -1.00908 0.608258 -1.40953

Fam13c family with sequence similarity 13, member C6.20E-06 -18.3712 6.69E-06 -17.8437 0.218685 -1.45146 0.253491 -1.40979

Ccdc93 coiled-coil domain containing 930.000105 2.96719 0.000145 2.82385 0.092251 -1.34191 0.05596 -1.41002

Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 20.0670187 -1.46317 0.361569 -1.1899 0.015468 -1.7345 0.091915 -1.41056

RGD1565629similar to collagen and calcium binding EGF domains 10.0018117 4.97958 0.006323 3.622 0.942598 -1.02641 0.355029 -1.41112

Dusp6 dual specificity phosphatase 60.0878273 2.12528 0.268788 1.58547 0.89765 -1.05285 0.400309 -1.41131

RGD1307315LOC362793 0.0008682 -1.66082 3.49E-05 -2.25214 0.693098 -1.04109 0.008025 -1.41177

Mgp matrix Gla protein 0.0053535 2.8303 0.092875 1.68946 0.551972 1.1861 0.244526 -1.41242

Ppic peptidylprolyl isomerase C1.11E-06 2.42196 7.52E-05 1.65133 0.594244 1.03824 0.000922 -1.41265

Fxyd5 FXYD domain-containing ion transport regulator 56.08E-06 3.27956 8.12E-06 3.13551 0.02945 -1.35061 0.016036 -1.41265


RGD1566355similar to cell division cycle 2-like 10.0394604 -1.35691 0.000236 -2.18287 0.32795 1.13812 0.023684 -1.41347

Pptc7 PTC7 protein phosphatase homolog (S. cerevisiae)0.0295079 -1.23568 0.095543 -1.16321 0.000953 -1.50161 0.002529 -1.41354

RGD1563060similar to AVLV472 1.45E-10 272.388 3.03E-10 165.464 0.302918 1.16354 0.035677 -1.41483

Bmp1 bone morphogenetic protein 11.43E-06 4.26033 1.75E-05 2.8255 0.593691 1.06568 0.016289 -1.41488

Sp110 SP110 nuclear body protein0.0038647 -1.68453 0.011491 -1.52751 0.009008 -1.56036 0.028252 -1.41491

Sspn sarcospan 1.33E-05 -4.4529 1.11E-05 -4.61779 0.085561 -1.36483 0.059926 -1.41537

Jdp2 Jun dimerization protein 20.0051509 -2.27961 0.001486 -2.77923 0.5091 -1.16112 0.146569 -1.4156

Cd302 CD302 molecule 0.0002364 3.53632 0.001768 2.51744 0.969499 -1.00796 0.121753 -1.41591

Bend5 BEN domain containing 54.96E-06 -2.1818 2.06E-07 -3.25786 0.487344 1.0543 0.001369 -1.4163

Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide4.67E-06 4.99668 3.71E-05 3.37227 0.769039 1.04617 0.047231 -1.4163

Serf2 small EDRK-rich factor 20.0002579 -2.86471 0.000663 -2.48974 0.020479 -1.63008 0.07406 -1.41672

Mrpl52 mitochondrial ribosomal protein L520.0146531 -1.55955 0.001142 -2.02863 0.566814 -1.08938 0.041073 -1.41705

Kcnmb4 potassium large conductance calcium-activated channel, subfamily M, beta member 40.0004137 2.64137 0.007674 1.811 0.869319 1.02895 0.071477 -1.41747

Npy neuropeptide Y 2.49E-06 -15.2123 1.23E-06 -19.7902 0.719904 -1.08974 0.169777 -1.41768

Atrx alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)0.0084684 -1.75861 0.000368 -2.60626 0.793253 1.0451 0.06421 -1.41804

Nus1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)5.58E-06 -1.6008 9.36E-08 -2.22605 0.667118 -1.02006 4.97E-05 -1.41848

Pink1 PTEN induced putative kinase 17.58E-06 -2.35818 7.02E-07 -3.23144 0.692997 -1.0352 0.003264 -1.41854

E330009J07RikRIKEN cDNA E330009J07 gene0.0001847 2.51941 0.001841 1.90992 0.622121 -1.07538 0.038955 -1.41855

Rab32 RAB32, member RAS oncogene family0.386691 1.18031 0.157342 1.32646 0.032711 -1.59495 0.089242 -1.41922

Ech1 enoyl coenzyme A hydratase 1, peroxisomal0.001953 -1.79498 0.000104 -2.50081 0.888445 -1.01892 0.026806 -1.41959

Shank2 SH3 and multiple ankyrin repeat domains 20.000484 -2.55483 0.001681 -2.1593 0.014186 -1.67989 0.067908 -1.41982

Igsf6 immunoglobulin superfamily, member 69.37E-05 5.95313 0.00085 3.61165 0.564811 1.16074 0.195437 -1.42005


of 148 Diabetes

Defb4 defensin beta 4 1.03E-09 372.452 1.85E-09 243.856 0.709113 1.07448 0.095023 -1.42147

Slurp1 secreted Ly6/Plaur domain containing 19.08E-07 -4.59633 2.06E-07 -6.34362 0.800977 -1.03005 0.014745 -1.42163

Sub1 SUB1 homolog (S. cerevisiae)9.37E-06 -2.75795 6.22E-06 -2.92013 0.020887 -1.34293 0.009034 -1.4219

Enah enabled homolog (Drosophila)2.03E-08 2.87001 3.59E-06 1.71774 0.010255 1.17476 8.38E-05 -1.42225

Tes testis derived transcript 7.80E-07 4.27901 3.35E-06 3.32509 0.372191 -1.10557 0.010526 -1.42274

Reck reversion-inducing-cysteine-rich protein with kazal motifs0.0002633 2.90326 0.001503 2.25502 0.576884 -1.10539 0.074725 -1.42315

Ttc30b tetratricopeptide repeat domain 30B0.0054126 -1.67571 0.000373 -2.23199 0.637193 -1.06929 0.032248 -1.42425

Snapc5 Small nuclear RNA activating complex, polypeptide 50.0027812 -1.92043 0.006108 -1.76177 0.020755 -1.55353 0.049683 -1.42518

PAK1 p21 protein (Cdc42/Rac)-activated kinase 12.09E-06 4.4115 4.48E-06 3.82701 0.123263 -1.23658 0.020652 -1.42544

Usp12 ubiquitin specific peptidase 120.0071442 -1.83481 0.000457 -2.62302 0.987077 1.00283 0.06961 -1.42554

Lyz2 lysozyme 2 9.20E-06 28.7564 4.03E-05 15.5951 0.471469 1.29251 0.325894 -1.42663

Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type3.16E-08 9.92754 1.33E-07 6.76252 0.80344 1.029 0.012658 -1.42664

Casp8 caspase 8 0.0166636 -1.64057 0.002044 -2.08771 0.504946 -1.1214 0.062167 -1.42704

Ptprd protein tyrosine phosphatase, receptor type, D0.0491849 -2.93922 0.023089 -3.68614 0.788358 -1.13792 0.466731 -1.42708

Klf11 Kruppel-like factor 11 0.0006064 -1.8548 3.04E-06 -3.66359 0.020949 1.38363 0.013761 -1.42755

Lsm6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.201038 -1.18435 0.551461 1.07842 0.001126 -1.82334 0.018958 -1.42758

Vasn vasorin 0.0022184 -1.49239 4.08E-05 -2.07733 0.782959 -1.02613 0.004308 -1.42831

LOC100362940 /// LOC100364126sorting nexin 21-like /// sorting nexin 21-like1.78E-05 -2.29109 1.25E-05 -2.38505 0.008581 -1.37277 0.004559 -1.42907

Aktip AKT interacting protein0.0001231 -1.95613 1.15E-05 -2.53941 0.351265 -1.10086 0.006239 -1.42912

Far1 fatty acyl CoA reductase 10.0177969 2.87613 0.532429 1.26094 0.22478 1.59602 0.344421 -1.42915

Igfbp6 insulin-like growth factor binding protein 60.0749189 -1.30305 0.404626 -1.12053 0.004335 -1.66331 0.024411 -1.43032

Rap2b RAP2B, member of RAS oncogene family0.0465052 -1.40267 0.153931 -1.25425 0.011303 -1.6013 0.037197 -1.43186


Dram damage-regulated autophagy modulator0.0001202 3.30322 0.001341 2.28974 0.968318 1.00709 0.070452 -1.43247

Prpf18 PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)0.0050454 -1.34051 0.014284 -1.26969 0.000644 -1.51249 0.001555 -1.43258

SNX10 sorting nexin 10 0.0232015 1.73216 1.05E-05 6.7383 2.27E-05 -5.57429 0.104098 -1.43294

Thbd thrombomodulin 4.44E-06 2.86052 9.19E-05 2.00336 0.970948 -1.00363 0.005773 -1.43305

RGD1563941similar to hypothetical protein FLJ200100.0010036 -1.75516 9.51E-05 -2.22714 0.305513 -1.13001 0.012099 -1.43388

Phactr1 phosphatase and actin regulator 10.0805973 2.02502 0.419594 1.35022 0.901946 1.0459 0.336982 -1.43396

Scin Scinderin 0.0015977 -1.63472 8.63E-05 -2.14869 0.431677 -1.091 0.008995 -1.43402

Il18r1 interleukin 18 receptor 10.001808 -2.07963 0.000717 -2.33936 0.166451 -1.27569 0.053892 -1.43501

Sh3yl1 SH3 domain containing, Ysc84-like 1 (S. cerevisiae)0.0044207 -1.85036 0.000482 -2.42784 0.583862 -1.09374 0.050408 -1.43509

Rnf39 ring finger protein 39 0.0223063 -1.52234 0.000588 -2.25904 0.833702 1.03279 0.040773 -1.43681

Cd69 Cd69 molecule 0.0004998 2.06761 0.033935 1.39139 0.804806 1.03358 0.022921 -1.43772

Fkbp11 FK506 binding protein 115.59E-07 5.38257 2.54E-05 2.7593 0.032193 1.35627 0.014955 -1.43828

of 148Diabetes

Wdr45 WD repeat domain 45 0.0017314 -1.48009 2.12E-05 -2.12067 0.955586 -1.0049 0.002665 -1.43982

Hsdl2 hydroxysteroid dehydrogenase like 20.0032318 -1.76717 0.000478 -2.17515 0.286045 -1.17003 0.029021 -1.44015

RGD1565975RGD1565975 7.72E-09 14.4138 1.96E-08 10.7067 0.549419 -1.06985 0.009689 -1.44027

Rora RAR-related orphan receptor A2.49E-05 -2.32007 8.13E-07 -3.76508 0.255983 1.12649 0.005624 -1.44061

LOC680222 similar to zinc finger protein 748 isoform 25.30E-07 -2.94181 5.99E-07 -2.89171 0.000929 -1.46565 0.001237 -1.44069

Ugt1a1 /// Ugt1a2 /// Ugt1a3 /// Ugt1a5 /// Ugt1a6 /// Ugt1a7c /// Ugt1a8 /// Ugt1a9UDP glucuronosyltransferase 1 family, polypeptide A1 /// UDP glucuronosyltransferase 1 0.0002502 4.05563 0.000127 4.69087 0.052496 -1.66689 0.142395 -1.44116

Prkca protein kinase C, alpha0.0008189 2.74541 0.003011 2.25798 0.405876 -1.18564 0.09625 -1.44158

Cdkn1b cyclin-dependent kinase inhibitor 1B0.0005546 -2.16952 4.32E-05 -3.07173 0.899081 -1.01851 0.030976 -1.44206

Akap9 A kinase (PRKA) anchor protein (yotiao) 90.0854492 -1.29936 0.00024 -2.3101 0.155852 1.23261 0.025303 -1.44237

Ccdc93 coiled-coil domain containing 935.18E-05 3.28836 5.22E-05 3.28411 0.043342 -1.44105 0.042771 -1.44292

Has2 hyaluronan synthase 2 0.0095271 6.93165 0.023054 4.96466 0.954687 -1.03407 0.538411 -1.44377

Ppp4r2 protein phosphatase 4, regulatory subunit 20.0002298 -1.79662 1.08E-05 -2.4575 0.575646 -1.05565 0.004188 -1.44398

Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform0.0024252 -1.33914 5.91E-06 -2.02108 0.538201 1.04405 0.000576 -1.44557

Tmco4 transmembrane and coiled-coil domains 40.0011788 -1.82818 0.000405 -2.03933 0.067847 -1.29602 0.017078 -1.44571


5031439G07RikRIKEN cDNA 5031439G07 gene0.0003063 -1.43814 2.28E-06 -2.04417 0.780883 -1.01743 0.000276 -1.44618


Paip2 poly(A) binding protein interacting protein 27.20E-05 -1.72723 1.68E-06 -2.47864 0.909031 -1.00868 0.000992 -1.44749

SEC62 SEC62 homolog (S. cerevisiae)2.10E-05 -1.76321 1.82E-06 -2.19465 0.046287 -1.16295 0.000419 -1.44751

Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 20.0431531 -1.41102 0.001064 -2.04625 0.991527 1.00157 0.032601 -1.44792

Rnf152 ring finger protein 152 5.63E-06 -5.31621 2.35E-06 -6.52618 0.324874 -1.18046 0.047021 -1.44914

Gtlf3b gene trap locus F3b 8.15E-05 -2.21649 1.25E-05 -2.80435 0.246526 -1.1454 0.00913 -1.44919


Phf14 PHD finger protein 14 0.0078514 -1.46416 0.000127 -2.10795 0.952671 -1.00666 0.009017 -1.44928

LOC100910497paired immunoglobulin-like type 2 receptor alpha-like0.0175117 3.33218 0.095147 2.14533 0.868312 1.07152 0.384374 -1.44956

Ctnnd2 Catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat p0.0017448 -2.7818 0.000244 -4.01619 0.98569 -1.00412 0.133202 -1.44969

RT1-S3 RT1 class Ib, locus S3 0.0463013 -1.70554 0.092667 -1.54148 0.0706 -1.60408 0.139953 -1.44978

Ggct gamma-glutamyl cyclotransferase0.0004038 2.04811 0.000707 1.93053 0.035337 -1.36667 0.016889 -1.4499

Tmem205 transmembrane protein 2050.0003299 -1.62288 8.82E-06 -2.2374 0.549908 -1.05182 0.001775 -1.4501

Dnase1l3 deoxyribonuclease 1-like 33.74E-07 5.15844 4.03E-06 3.33034 0.563654 1.06781 0.009164 -1.45056

Rabac1 Rab acceptor 1 (prenylated)1.24E-05 -2.18886 7.46E-07 -3.11237 0.804546 -1.02131 0.001936 -1.45222


Gpx7 glutathione peroxidase 71.83E-07 3.1511 6.09E-07 2.67317 0.016525 -1.23385 0.000657 -1.45445

RGD1311678similar to 4921517L17Rik protein6.96E-06 -1.98389 8.96E-07 -2.45236 0.040642 -1.17666 0.0005 -1.45452

Bag2 Bcl2-associated athanogene 22.18E-05 2.68855 0.000245 2.01851 0.452344 -1.0928 0.010209 -1.45556

of 148 Diabetes

Hbp1 HMG-box transcription factor 10.0538852 -1.30713 0.000316 -2.04231 0.567746 1.07323 0.013266 -1.45583

Gabbr1 gamma-aminobutyric acid (GABA) B receptor 10.0001167 -2.11194 1.38E-05 -2.73278 0.296897 -1.12725 0.007886 -1.45862

Hsph1 heat shock 105kDa/110kDa protein 12.72E-05 3.81954 0.0002 2.74856 0.765148 -1.04969 0.042753 -1.4587

Aldh6a1 aldehyde dehydrogenase 6 family, member A15.15E-06 -2.44557 1.21E-06 -2.95027 0.052815 -1.20926 0.001967 -1.45882

Me3 malic enzyme 3, NADP(+)-dependent, mitochondrial0.0019337 -1.93361 0.003561 -1.81046 0.015966 -1.55806 0.032001 -1.45883

Klk6 kallikrein related-peptidase 60.0004123 31.3544 0.00082 22.1612 0.960209 -1.03113 0.543718 -1.45888


Utrn Utrophin 0.0043176 -1.48528 6.85E-05 -2.12741 0.858501 -1.01868 0.00555 -1.45908

RGD1563888similar to DNA segment, Chr 16, ERATO Doi 472, expressed0.0006472 -1.80295 0.000133 -2.10831 0.075199 -1.25005 0.008356 -1.46176

Kifc3 kinesin family member C30.0002562 -1.88986 2.10E-05 -2.47643 0.316991 -1.11557 0.005997 -1.46182

LOC1003632535'-nucleotidase, cytosolic II0.0309419 -1.50632 0.00115 -2.16551 0.916987 -1.017 0.041617 -1.46206

RGD1562407similar to WAC 0.0002195 -1.97537 2.30E-05 -2.55047 0.27891 -1.1325 0.007545 -1.4622

Tgfa transforming growth factor alpha0.0001974 3.19401 0.000571 2.69199 0.278941 -1.2324 0.067677 -1.46223

Rdh10 Retinol dehydrogenase 10 (all-trans)0.0001116 3.76668 0.000305 3.14249 0.322952 -1.22056 0.079169 -1.46299

Ypel5 yippee-like 5 (Drosophila)0.0001834 -2.22237 1.82E-05 -3.01807 0.556374 -1.07803 0.014358 -1.46402

Ndrg2 N-myc downstream regulated gene 20.0023031 2.31344 0.046554 1.56649 0.969571 1.00754 0.080073 -1.46578

Igfbp7 insulin-like growth factor binding protein 73.09E-06 65.3063 1.94E-05 26.2634 0.186865 1.69479 0.32486 -1.46719

Vcan versican 0.0008107 2.23972 0.01634 1.59777 0.77114 -1.04766 0.037884 -1.46859

Dbn1 drebrin 1 0.0014094 2.60679 0.011572 1.92389 0.698609 -1.08398 0.092018 -1.46875

Emp3 epithelial membrane protein 32.61E-07 9.65393 9.73E-07 6.76864 0.842075 -1.03003 0.028096 -1.4691

RGD1305627hypothetical LOC3144670.0014773 -4.44914 8.57E-05 -9.92727 0.222018 1.51837 0.257019 -1.46952

ArfGAP with coiled-coil, ankyrin repeat and PH domains 3Acap3 0.000714 -1.62615 2.71E-05 -2.18422 0.353573 -1.09424 0.002952 -1.46977

St13 suppression of tumorigenicity 130.000714 -1.62615 2.71E-05 -2.18422 0.353573 -1.09424 0.002952 -1.46977

Gse1 genetic suppressor element 1 [1.53E-05 -2.02439 8.51E-07 -2.81095 0.474032 -1.05903 0.000988 -1.47051

Vash2 vasohibin 2 0.0019913 3.32797 0.037932 1.94031 0.581306 1.1658 0.186091 -1.47124

Ptpla protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a0.0028443 1.90851 0.001307 2.08823 0.014182 -1.60983 0.035142 -1.47129

Pdk1 pyruvate dehydrogenase kinase, isozyme 10.0011222 2.03691 0.007128 1.67442 0.22178 -1.20981 0.027573 -1.47172

Micalcl MICAL C-terminal like 0.124506 -1.27376 0.000534 -2.19078 0.301306 1.1686 0.025419 -1.47179

LOC689360 similar to glyceraldehyde 3-phosphate dehydrogenase0.0004578 -2.22831 0.000313 -2.33618 0.042467 -1.40389 0.025193 -1.47186

Gch1 GTP cyclohydrolase 1 2.64E-05 3.43599 0.000228 2.48412 0.677041 -1.06419 0.027689 -1.47196

Stk10 serine/threonine kinase 100.0046458 -1.9308 0.173129 -1.28829 0.001599 -2.20619 0.051847 -1.47204

Cybb cytochrome b-245, beta polypeptide0.0019283 4.58575 0.024876 2.5255 0.551338 1.23261 0.28264 -1.47311

Ptprd protein tyrosine phosphatase, receptor type, D0.0610373 -2.53327 0.018614 -3.51155 0.888338 -1.06381 0.389341 -1.47462

Fbxo9 f-box protein 9 0.0044401 -1.45655 6.84E-05 -2.05733 0.665695 -1.04401 0.00371 -1.47463

Ppap2b phosphatidic acid phosphatase type 2B2.48E-05 -3.20985 7.72E-06 -3.91829 0.197917 -1.20842 0.020414 -1.47513

of 148Diabetes

Dstyk dual serine/threonine and tyrosine protein kinase8.00E-05 -1.66948 6.63E-06 -2.056 0.031687 -1.19868 0.000519 -1.4762

Heca headcase homolog (Drosophila)6.02E-05 -2.42958 3.22E-06 -3.7445 0.720055 1.04403 0.00999 -1.47621

Vcl Vinculin 0.0001348 2.29327 0.011556 1.4865 0.727703 1.04485 0.012557 -1.47651

Ankrd12 ankyrin repeat domain 120.0010595 -1.71569 0.000123 -2.11067 0.129472 -1.2004 0.006909 -1.47675

Chn2 Chimerin (chimaerin) 20.0004169 -2.9904 0.000127 -3.68708 0.368622 -1.19807 0.07372 -1.47719

Cav2 caveolin 2 /// caveolin 2-like0.0559274 -1.34912 0.07654 -1.31316 0.014315 -1.51836 0.019456 -1.47789

Ulk1 Unc-51 like kinase 1 (C. elegans)0.0017101 -1.67832 1.46E-05 -2.83479 0.268573 1.14253 0.008222 -1.47835

Slc22a18 solute carrier family 22, member 180.0064387 -1.78418 0.000997 -2.2226 0.310848 -1.18687 0.038753 -1.47852

Cd14 CD14 molecule 0.169167 -1.30728 0.002046 -2.21435 0.467807 1.1447 0.058057 -1.47975

Itga6 integrin, alpha 6 3.09E-06 2.98167 2.31E-05 2.30305 0.198219 -1.14341 0.003407 -1.48033

Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase0.0058055 -1.65729 0.00053 -2.12667 0.322305 -1.15367 0.020044 -1.48041

MGC95152 similar to B230212L03Rik protein0.0001305 -2.22122 5.81E-06 -3.40397 0.777845 1.03456 0.009724 -1.48127

Rab27a RAB27A, member RAS oncogene family0.0170095 -1.78258 0.00583 -2.04866 0.223114 -1.28955 0.075283 -1.48203

Pkp4 plakophilin 4 7.17E-05 -2.13152 6.71E-06 -2.84751 0.335703 -1.10945 0.004674 -1.48211

Pxdc1 PX domain containing 1 9.02E-07 8.33692 2.01E-05 4.07391 0.075332 1.38047 0.037273 -1.4824

Cst7 cystatin F (leukocystatin)0.0004827 2.04972 0.042313 1.35884 0.895393 1.0174 0.014686 -1.48264

Vcl vinculin 3.44E-06 2.52163 2.39E-05 2.04045 0.055986 -1.20109 0.00133 -1.48434

Baz2b bromodomain adjacent to zinc finger domain, 2B0.0002467 -1.39402 5.01E-07 -2.16223 0.43752 1.04441 7.36E-05 -1.48511

LOC363060 similar to RIKEN cDNA 1600029D210.0001079 -2.18008 1.87E-05 -2.70334 0.14164 -1.19771 0.007243 -1.48519

Plbd1 phospholipase B domain containing 12.66E-06 4.77832 9.53E-07 5.98376 0.001679 -1.86165 0.018242 -1.48662

Egr2 early growth response 20.0353464 2.90431 0.151998 1.94974 0.997163 1.00155 0.374094 -1.48728

Rbbp6 retinoblastoma binding protein 60.0479696 -1.41557 0.001406 -2.03577 0.825518 -1.03452 0.028517 -1.48778

Me1 malic enzyme 1, NADP(+)-dependent, cytosolic1.27E-06 4.93362 1.72E-06 4.63806 0.026973 -1.39902 0.01262 -1.48817

Sh3kbp1 SH3-domain kinase binding protein 11.49E-05 2.91559 0.000169 2.14346 0.458436 -1.0941 0.008778 -1.48822

Timp2 TIMP metallopeptidase inhibitor 20.0001691 3.41599 0.009068 1.89022 0.327315 1.21427 0.065099 -1.4883

Agl amylo-1,6-glucosidase, 4-alpha-glucanotransferase0.0012371 -1.67281 0.007705 -1.45216 0.000919 -1.71526 0.005468 -1.48901

Ptger4 Prostaglandin E receptor 40.0030198 4.36943 0.041539 2.3455 0.543474 1.24991 0.289211 -1.49043

Slc44a4 solute carrier family 44, member 40.0002373 -2.71431 5.28E-05 -3.45056 0.344299 -1.17322 0.036091 -1.49145

Acp5 acid phosphatase 5, tartrate resistant1.32E-06 3.89714 3.30E-05 2.42324 0.499588 1.07816 0.005565 -1.49165

Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.000226 -1.72978 3.52E-05 -2.04195 0.027003 -1.26362 0.001716 -1.49167


C2cd4d C2 calcium-dependent domain containing 4D0.0032102 -1.74214 5.21E-05 -2.84092 0.525437 1.09287 0.017289 -1.49213

RGD1562997similar to Transcription initiation factor TFIID 105 kDa subunit (TAFII-105)0.0043988 1.54952 0.000304 1.96622 0.000445 -1.8934 0.007135 -1.49213

Odz3 odz, odd Oz/ten-m homolog 3 (Drosophila)0.0138425 -2.18656 0.00185 -3.11673 0.857636 -1.04727 0.146699 -1.49278

Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.0002139 -5.15046 4.02E-05 -7.99903 0.883483 1.03964 0.156917 -1.49385

of 148 Diabetes

Dcn decorin 0.0111071 2.24218 0.298643 1.31418 0.604385 1.14174 0.14088 -1.49433

EGR3 early growth response 30.0068177 6.45725 0.067245 2.97823 0.491477 1.45038 0.458107 -1.49488


Bbs1 Bardet-Biedl syndrome 10.003818 -2.04969 0.013033 -1.7626 0.014588 -1.73929 0.053943 -1.49567

Flnb filamin, beta 9.92E-06 2.83481 0.000347 1.88064 0.950488 1.00684 0.005292 -1.49712



Myadm myeloid-associated differentiation marker5.07E-07 8.68174 1.13E-06 7.00514 0.238977 -1.20916 0.026663 -1.49856

Thnsl2 threonine synthase-like 2 (S. cerevisiae)6.94E-05 -2.03034 5.21E-06 -2.7405 0.299283 -1.11053 0.002668 -1.49897

Chn2 Chimerin (chimaerin) 20.0004692 -2.70039 6.16E-05 -3.80158 0.729012 -1.06486 0.049554 -1.49909

Paip1 Poly(A) binding protein interacting protein 16.28E-08 -1.83377 1.49E-08 -2.07084 2.05E-05 -1.3291 1.41E-06 -1.50092

Mgll Monoglyceride lipase 0.362922 1.17032 0.294256 1.20079 0.029316 -1.54003 0.037461 -1.50096

Myo1d myosin ID 0.003305 1.59876 0.079107 1.25685 0.183296 -1.18006 0.007253 -1.50108

Pdcl3 phosducin-like 3 0.229953 1.06624 0.000413 -1.33033 0.284396 -1.05826 3.56E-05 -1.50109

Ctsz cathepsin Z 3.38E-08 8.70882 2.41E-08 9.57131 0.001463 -1.65023 0.0049 -1.50153

Dstyk dual serine/threonine and tyrosine protein kinase0.0347869 -1.38702 0.003276 -1.70384 0.157534 -1.22257 0.013482 -1.50183

Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 16.59E-05 2.82945 0.001232 1.95676 0.786319 -1.03936 0.018184 -1.50289

Tlr4 toll-like receptor 4 0.002476 1.34257 0.000883 1.41758 0.000137 -1.58718 0.000321 -1.5032

Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 250.467298 1.16837 0.883672 -1.03128 0.309319 -1.24775 0.080556 -1.50343

Ifngr2 interferon gamma receptor 24.39E-06 -4.55405 3.71E-06 -4.71234 0.027416 -1.45325 0.018769 -1.50377

RGD1565705similar to chr2 synaptotagmin0.0058078 1.46927 0.311154 1.11806 0.226013 -1.14499 0.004188 -1.50465


C8g complement component 8, gamma polypeptide2.95E-05 -2.56705 3.88E-06 -3.45139 0.342022 -1.11933 0.006378 -1.50493

Hpcal1 hippocalcin-like 1 0.597833 1.03926 0.017488 -1.23274 0.050015 -1.17548 0.000387 -1.50596

Myh6 myosin, heavy chain 6, cardiac muscle, alpha0.0725228 1.54215 0.980346 -1.00534 0.893172 1.02947 0.086432 -1.506

Acvr1 activin A receptor, type I5.55E-05 3.30706 0.000375 2.47668 0.458389 -1.12797 0.029277 -1.50616

Ccng2 cyclin G2 0.0692015 1.31882 0.704829 -1.05317 0.556129 -1.08441 0.014568 -1.50618

RGD1359529similar to chromosome 1 open reading frame 630.0001945 -4.36104 0.000102 -5.03918 0.277607 -1.30372 0.109595 -1.50645

Mphosph8 /// Parp4M-phase phosphoprotein 8 /// poly (ADP-ribose) polymerase family, member 40.722364 -1.07681 0.093726 -1.46573 0.626717 -1.10702 0.075759 -1.50684

Slc20a1 solute carrier family 20 (phosphate transporter), member 18.37E-06 2.24904 0.000349 1.61597 0.353142 -1.08301 0.000963 -1.5073

Ndrg4 N-myc downstream regulated gene 40.0657427 -1.31321 0.000323 -2.15457 0.528083 1.08801 0.012391 -1.50797

Tmem98 transmembrane protein 980.300627 1.11776 0.909651 -1.01185 0.021154 -1.33336 0.003516 -1.50804

Steap4 STEAP family member 4 2.47E-08 33.9189 5.81E-08 23.5986 0.778158 -1.04937 0.037811 -1.50829

Rnf19a ring finger protein 19A 0.176711 1.20072 0.904925 1.01534 0.083788 -1.27601 0.010344 -1.50899

Pgap2 Post-GPI attachment to proteins 27.05E-06 -2.73355 2.85E-06 -3.10678 0.020156 -1.32792 0.003012 -1.50923

of 148Diabetes

Pmepa1 prostate transmembrane protein, androgen induced 12.90E-05 4.12208 0.00013 3.15069 0.417788 -1.15365 0.039288 -1.50933

Tpm3 tropomyosin 3, gamma 9.83E-05 2.13723 0.000449 1.83628 0.04001 -1.2977 0.004708 -1.51038

Pink1 PTEN induced putative kinase 13.84E-05 -2.59285 2.47E-06 -3.96507 0.919448 1.01228 0.007766 -1.51068

Ivl involucrin 0.0020421 1.76846 0.876002 -1.02069 0.198944 1.19485 0.011777 -1.5107

Scrn1 secernin 1 8.71E-05 -3.61795 0.001606 -2.28564 0.001155 -2.39257 0.04795 -1.5115

Klf7 Kruppel-like factor 7 (ubiquitous)0.0002428 2.88438 0.005686 1.88362 0.942333 1.01271 0.04032 -1.51208

Wdr26 WD repeat domain 26 0.0050162 1.28996 0.027601 -1.1956 0.777076 1.01966 0.000252 -1.51255

Rdh7 retinol dehydrogenase 70.189379 1.57285 0.889035 1.04653 0.984042 -1.00654 0.226247 -1.51275

Jkamp JNK1/MAPK8-associated membrane protein0.0387539 -1.18613 0.000336 -1.51053 0.03736 -1.18806 0.000327 -1.51299

Aif1l allograft inflammatory factor 1-like0.718534 -1.10545 0.310185 -1.33759 0.42925 -1.25047 0.16151 -1.51306

Nubpl nucleotide binding protein-like0.0284003 -1.5265 0.005092 -1.83182 0.181555 -1.26096 0.030946 -1.51318

Atp5s ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)0.0004074 -3.50344 0.000118 -4.50375 0.472589 -1.17712 0.091858 -1.51321

Baz1a bromodomain adjacent to zinc finger domain, 1A0.585261 1.04907 0.014173 -1.30097 0.25539 -1.10874 0.00117 -1.51322

LOC687118 similar to death effector domain-containing DNA binding protein 20.0454087 1.64157 0.792411 1.05862 0.910396 1.02461 0.083123 -1.51341

Crebl2 cAMP responsive element binding protein-like 20.0006015 -1.68287 1.25E-05 -2.47273 0.764199 -1.03003 0.002455 -1.51348

Tspan2 tetraspanin 2 3.18E-05 4.07822 0.000975 2.34291 0.431666 1.14944 0.038876 -1.51436

Znf292 zinc finger protein 292 0.0006051 -1.48318 1.16E-05 -1.99962 0.146378 -1.12326 0.000432 -1.51438

Tgfa transforming growth factor alpha0.0001562 3.24308 0.000286 2.93491 0.111187 -1.37081 0.046169 -1.51474

Ramp1 receptor (G protein-coupled) activity modifying protein 10.0001148 2.14277 0.002695 1.59526 0.302659 -1.1278 0.005205 -1.51488

Clp1 CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)0.0209889 -1.64167 0.008039 -1.8334 0.115809 -1.35682 0.043041 -1.51529

Apoc1 apolipoprotein C-I 0.0004948 -3.00536 9.98E-05 -4.02623 0.546054 -1.1312 0.066247 -1.51545

Trim47 tripartite motif-containing 475.19E-07 5.60432 2.27E-06 4.14494 0.367155 -1.1209 0.008294 -1.51555

RGD1309621similar to hypothetical protein FLJ106527.00E-05 -2.00978 1.56E-05 -2.3594 0.025407 -1.29106 0.002106 -1.51565

Nog noggin 0.0164889 1.77458 0.425018 1.17291 0.990972 -1.00222 0.059553 -1.51633

LOC366300 hypothetical LOC3663000.0558306 -1.2917 0.001455 -1.72168 0.292614 -1.13768 0.006628 -1.51639

Abcg1 ATP-binding cassette, sub-family G (WHITE), member 12.61E-05 -2.14538 3.18E-06 -2.75189 0.096345 -1.1822 0.00157 -1.51642

Foxn3 forkhead box N3 0.0010219 -1.57034 2.53E-05 -2.17023 0.33054 -1.09752 0.001671 -1.51679

Nat1 /// Nat2N-acetyltransferase 1 (arylamine N-acetyltransferase) /// N-Acetyltransferase-2 (arylam0.031442 -1.37512 0.004746 -1.60543 0.064743 -1.29935 0.009277 -1.51697

Fbxo33 F-box protein 33 0.687192 -1.02794 0.006713 -1.27043 0.014545 -1.22744 0.000229 -1.51699

Ttll7 tubulin tyrosine ligase-like family, member 71.35E-07 3.67503 8.87E-07 2.77713 0.109084 -1.14655 0.000577 -1.51726

Timp3 TIMP metallopeptidase inhibitor 30.0303038 -1.71177 0.114679 -1.43639 0.020019 -1.80844 0.075845 -1.51751

RGD1311122similar to RIKEN cDNA 1110003E010.0001077 1.96404 0.103722 1.19231 0.417023 1.08545 0.002435 -1.51757

Prdm1 PR domain containing 1, with ZNF domain0.0133358 -1.46796 0.000415 -2.01668 0.434701 -1.10496 0.008835 -1.51799

Senp7 SUMO1/sentrin specific peptidase 70.0017088 -2.23971 0.000211 -3.05035 0.551181 -1.11468 0.0437 -1.51812

Gatad2a GATA zinc finger domain containing 2A1.00E-05 -1.80679 5.17E-06 -1.9084 0.000323 -1.4376 0.000124 -1.51845

of 148 Diabetes

Lamc1 laminin, gamma 1 0.0008894 1.56179 0.209313 1.12582 0.327676 -1.09471 0.001333 -1.51863

Brwd1 bromodomain and WD repeat domain containing 10.0312788 -1.43099 0.01009 -1.58475 0.050668 -1.3714 0.016065 -1.51875

Slco2a1 solute carrier organic anion transporter family, member 2a10.159154 -1.33419 0.00029 -3.10394 0.050773 1.5318 0.054549 -1.51878

Zhx2 Zinc fingers and homeoboxes 20.0080626 -1.49839 0.000285 -2.02614 0.342819 -1.12351 0.006774 -1.51922

App amyloid beta (A4) precursor protein0.0003488 -1.85243 0.000135 -2.03092 0.013809 -1.38583 0.003814 -1.51936

Lypd6b LY6/PLAUR domain containing 6B1.63E-07 15.0475 1.31E-06 7.93349 0.20791 1.24826 0.032383 -1.51948

Itgb3 Integrin, beta 3 0.0109706 1.9015 0.513268 1.14281 0.654669 1.09488 0.064315 -1.51969

Rasl10a RAS-like, family 10, member A7.06E-05 -3.62758 9.04E-06 -5.51849 0.99575 1.00095 0.041196 -1.51982

Kpna1 Karyopherin alpha 1 9.16E-05 -1.36752 4.96E-07 -1.87815 0.046661 -1.10742 1.10E-05 -1.52093

Tmem45b transmembrane protein 45b2.53E-06 8.89105 1.53E-05 5.58208 0.811148 1.04704 0.054246 -1.52122

LIPG lipase, endothelial 1.10E-05 4.31596 0.000107 2.90855 0.873761 -1.02516 0.02433 -1.52123

LOC1003632535'-nucleotidase, cytosolic II0.679275 1.09752 0.149106 -1.41378 0.930728 1.01965 0.088966 -1.52175

RGD1304982similar to RIKEN cDNA 2810025M150.0539818 1.23045 0.835325 1.01993 0.035407 -1.26139 0.001827 -1.52175

Tm9sf4 transmembrane 9 superfamily protein member 40.0028517 1.27542 0.302245 1.06537 0.003088 -1.27115 8.29E-05 -1.52178


Abcg2 ATP-binding cassette, sub-family G (WHITE), member 20.0004751 2.47793 0.011275 1.69028 0.818914 -1.03865 0.030498 -1.52265

Msra methionine sulfoxide reductase A0.0799479 1.44634 0.192624 1.29941 0.126523 -1.36882 0.051488 -1.52359

GK5 glycerol kinase 5 (putative)2.66E-05 3.12667 4.40E-05 2.8957 0.032186 -1.41112 0.013287 -1.52367

Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast)0.0001139 1.56998 0.003142 1.30843 0.006002 -1.2701 0.000183 -1.52398

Tprkb Tp53rk binding protein 8.23E-06 -2.27952 2.12E-06 -2.68141 0.013429 -1.29585 0.000888 -1.52431

Exoc5 exocyst complex component 50.0007556 1.95243 0.002771 1.71697 0.049671 -1.34088 0.010502 -1.52477

Sgpl1 sphingosine-1-phosphate lyase 10.0006129 1.34171 0.166901 1.08556 0.004601 -1.23381 5.17E-05 -1.52495

Akap13 A kinase (PRKA) anchor protein 130.0034921 -1.29584 7.74E-07 -2.38384 0.01825 1.20609 0.000159 -1.52526

Loxl2 lysyl oxidase-like 2 0.0044783 1.70856 0.464142 1.11104 0.955795 1.00786 0.015014 -1.5258

Myo5a myosin VA 1.30E-06 3.94136 6.55E-05 2.24632 0.228657 1.14975 0.004246 -1.52605

Fermt2 fermitin family homolog 2 (Drosophila)0.0008647 1.71467 0.016009 1.37434 0.090105 -1.22316 0.003715 -1.52605

Man1a1 mannosidase, alpha, class 1A, member 10.249233 -1.15173 0.01819 -1.39985 0.080106 -1.25579 0.005878 -1.52633

Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 10.148685 -1.24025 0.032442 -1.41633 0.063435 -1.3366 0.013831 -1.52636

Fam20c family with sequence similarity 20, member C0.427952 1.09221 0.173488 1.17097 0.001604 -1.63761 0.003894 -1.52746

Fggy FGGY carbohydrate kinase domain containing0.764733 -1.05278 0.067899 -1.41971 0.474585 -1.13273 0.034156 -1.52752

Anxa3 annexin A3 0.0196051 1.84247 0.129613 1.42596 0.447751 -1.18255 0.078259 -1.52796

Etv1 ets variant 1 0.0091079 -1.49231 7.92E-05 -2.36755 0.761022 1.03754 0.006719 -1.52909

Slit2 slit homolog 2 (Drosophila)0.0287065 1.52581 0.724837 -1.05958 0.737974 1.05652 0.027907 -1.53023

F3 coagulation factor III (thromboplastin, tissue factor)0.346834 1.16069 0.045275 -1.42375 0.621179 1.07964 0.021311 -1.53064

Rsbn1l round spermatid basic protein 1-like0.232938 -1.14386 0.008362 -1.43635 0.093503 -1.21925 0.003489 -1.53102

of 148Diabetes

LOC687839 hypothetical protein LOC6878390.0096836 -1.30069 3.25E-05 -1.91343 0.621586 -1.04077 0.000593 -1.53106

Irf9 interferon regulatory factor 90.0328573 1.67038 0.039333 1.63239 0.07749 -1.49686 0.064755 -1.5317

Rbbp6 retinoblastoma binding protein 60.623738 -1.0452 0.000486 -1.6304 0.840234 1.01821 0.00116 -1.53201

ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 11.85E-06 -1.79328 2.03E-07 -2.17645 0.001225 -1.26231 1.95E-05 -1.53203

Prtfdc1 phosphoribosyl transferase domain containing 12.50E-06 4.19401 0.00028 2.11127 0.066195 1.29579 0.008013 -1.53304

Cdh11 cadherin 11 0.136597 1.50831 0.788714 1.07126 0.740297 -1.08898 0.123615 -1.53327

Hist1h3f /// Hist2h3c /// Hist2h3c2 /// LOC100364555 /// LOC680498 /// LOC684762 /// LOC684819 /// LOC684841histone cluster 1, H3f /// histone cluster 2, H3c /// histone cluster 2, H3c2 //0.0018503 1.76671 0.027886 1.39739 0.160802 -1.21276 0.009028 -1.53328

Slc9a6 solute carrier family 9 (sodium/hydrogen exchanger), member 60.091141 1.28576 0.619419 1.06997 0.099558 -1.27614 0.01143 -1.5335

Pcdhb9 protocadherin beta 9 0.220705 -1.16414 0.008851 -1.48194 0.141467 -1.20521 0.005698 -1.53422

SRGAP2 SLIT-ROBO Rho GTPase activating protein 20.0068785 -1.55769 0.006926 -1.55678 0.008157 -1.5355 0.008214 -1.5346

Armc8 armadillo repeat containing 80.0613469 -1.39442 0.072059 -1.37255 0.019737 -1.55909 0.023137 -1.53464

LOC100362252Zinc finger protein 53-like0.0740196 -1.23082 0.006048 -1.45354 0.031886 -1.29992 0.002838 -1.53516

RGD1311350similar to kIAA0367 0.103347 1.32531 0.637839 -1.07784 0.65051 -1.07477 0.023275 -1.53528

Inhba inhibin beta-A 0.00271 2.85759 0.064405 1.69326 0.710636 1.09906 0.119016 -1.53551

Arid4a AT rich interactive domain 4A (Rbp1 like)8.62E-05 -1.56335 3.16E-07 -2.57397 0.289275 1.07222 0.000115 -1.53554

Serpini1 serine (or cysteine) peptidase inhibitor, clade I, member 15.37E-06 -7.2799 3.47E-06 -8.19488 0.1348 -1.36425 0.050672 -1.53572

Txnrd1 thioredoxin reductase 10.0270856 2.00813 0.25271 1.37482 0.849857 -1.05179 0.13496 -1.53629

Pmepa1 prostate transmembrane protein, androgen induced 18.10E-05 4.28125 0.000351 3.23714 0.470252 -1.16211 0.061997 -1.53693

Gpr137b G protein-coupled receptor 137B0.0077624 -1.62499 0.000462 -2.18735 0.361503 -1.14248 0.014081 -1.53786


Mettl23 methyltransferase like 236.04E-05 -1.88143 5.89E-06 -2.38222 0.046474 -1.21469 0.000815 -1.53801

B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 64.57E-05 4.4064 0.000428 2.92479 0.913807 -1.02106 0.049827 -1.5383

Ifnk interferon kappa 0.0227043 2.12231 0.717194 1.10557 0.432164 1.24755 0.145721 -1.53874

Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 30.834999 1.16987 0.769159 1.24779 0.515968 -1.64123 0.570762 -1.53876

Prpf38b PRP38 pre-mRNA processing factor 38 (yeast) domain containing B0.771818 -1.0263 0.010199 -1.33531 0.08802 -1.18301 0.001073 -1.53921

Slc35a3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A30.286775 1.12342 0.325648 -1.11269 0.07544 -1.23149 0.002875 -1.53939

B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 20.207238 -1.18736 0.004 -1.64782 0.429927 -1.10964 0.008695 -1.53996

Slc35a2 solute carrier family 35, member A20.379062 1.10331 0.284811 -1.12868 0.078937 -1.23683 0.003485 -1.5402

Il1rap interleukin 1 receptor accessory protein0.0003702 2.85902 0.000626 2.6368 0.084566 -1.42144 0.041774 -1.54124

Pop5 Processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)0.0048518 -2.26149 0.002352 -2.52753 0.167551 -1.37904 0.075324 -1.54126

Ttc3 tetratricopeptide repeat domain 30.0150345 -1.3548 4.29E-05 -2.20253 0.606927 1.05414 0.002288 -1.54223

Adarb1 adenosine deaminase, RNA-specific, B10.504946 1.13423 0.474434 -1.14503 0.368474 -1.18765 0.043071 -1.54244

Exoc4 Exocyst complex component 40.045984 1.12132 0.786702 -1.01367 0.000235 -1.35714 1.96E-05 -1.54259

Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.0005357 -2.1749 3.44E-05 -3.17681 0.706343 -1.05611 0.014643 -1.54263

LOC682058 similar to nucleolar protein with MIF4G domain 10.368242 -1.17201 0.027885 -1.56245 0.406087 -1.15716 0.031404 -1.54265

of 148 Diabetes

Prickle1 prickle homolog 1 (Drosophila)0.0007878 1.99316 0.615051 1.07135 0.193013 1.20593 0.011009 -1.54272

Akr1cl2 aldo-keto reductase family 1, member C-like 20.0379492 -1.21882 0.053155 -1.19802 0.000478 -1.56951 0.000616 -1.54273

Senp2 Sumo1/sentrin/SMT3 specific peptidase 20.025253 -1.42226 0.005265 -1.62766 0.048331 -1.34811 0.009656 -1.54281

Kifap3 kinesin-associated protein 30.680425 -1.05523 0.00125 -1.84388 0.351556 1.13251 0.008728 -1.54293

Klhl2 kelch-like 2, Mayven (Drosophila)0.23228 -1.17404 0.001924 -1.75488 0.804489 -1.03228 0.008154 -1.54298

Rasa1 RAS p21 protein activator (GTPase activating protein) 10.0016084 1.4053 0.572573 -1.04382 0.506478 -1.05201 0.000342 -1.54316

Lrrfip1 leucine rich repeat (in FLII) interacting protein 10.0516544 -1.1798 0.000732 -1.46694 0.01742 -1.24124 0.000324 -1.54334

Pla2r1 phospholipase A2 receptor 13.86E-06 -5.76546 1.12E-06 -7.85053 0.45002 -1.13345 0.025011 -1.54336

Naprt1 nicotinate phosphoribosyltransferase domain containing 10.0225624 -1.299 0.004903 -1.42911 0.006493 -1.40331 0.001585 -1.54388

Nav2 neuron navigator 2 2.27E-05 1.97172 0.002566 1.39723 0.279747 -1.09405 0.000509 -1.54389

Gbas glioblastoma amplified sequence0.0001755 -1.87393 1.22E-05 -2.48654 0.151725 -1.16365 0.001895 -1.54407

LOC680097 similar to germinal histone H4 gene0.145214 -1.39991 0.038018 -1.67745 0.258391 -1.28868 0.070631 -1.54416

Dgcr6 DiGeorge syndrome critical region gene 60.126515 -1.27042 0.008414 -1.62798 0.220329 -1.20514 0.014744 -1.54433

Klf5 Kruppel-like factor 5 0.869665 -1.04866 0.775144 -1.08639 0.192162 -1.49097 0.159639 -1.54462

Hip1 huntingtin interacting protein 13.62E-07 3.94813 1.56E-05 2.30852 0.29538 1.10703 0.001375 -1.54489

Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.30163 -1.22538 0.015517 -1.75733 0.696083 -1.0774 0.045698 -1.54511

STXBP6 syntaxin binding protein 6 (amisyn)1.02E-07 5.46997 6.41E-07 3.82546 0.439839 -1.08074 0.001859 -1.54533

Wnt7a wingless-type MMTV integration site family, member 7A0.0003045 4.48942 0.003562 2.74729 0.827883 1.05731 0.117289 -1.54556

Mllt10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocate0.0025315 -1.79092 5.69E-05 -2.82631 0.882781 1.02073 0.011995 -1.54609

Setd5 SET domain containing 5 0.57141 -1.09219 0.004316 -1.80097 0.677905 1.06652 0.01942 -1.5461

Spata6 spermatogenesis associated 60.0675474 1.17338 0.572779 -1.04549 0.015625 -1.26036 0.000424 -1.54616

ST7 suppression of tumorigenicity 70.0004722 1.66265 0.004612 1.4176 0.015105 -1.31835 0.001259 -1.54625

Fam213b family with sequence similarity 213, member B0.0004639 -1.5603 4.05E-06 -2.37285 0.834923 -1.017 0.000529 -1.54662

Sdcbp2 syndecan binding protein (syntenin) 20.218053 1.78101 0.422747 1.44018 0.618311 -1.25077 0.341968 -1.54677

Pgm2l1 phosphoglucomutase 2-like 10.0017782 -1.73436 0.000214 -2.14917 0.101237 -1.24871 0.006597 -1.54737

RGD1560859similar to 2300003P22Rik protein0.0031927 7.03029 0.001451 9.28885 0.166173 -2.04468 0.379576 -1.54752

Plau plasminogen activator, urokinase0.0001358 8.40578 0.000428 6.03052 0.746282 -1.11031 0.199666 -1.54762

Abhd5 abhydrolase domain containing 50.0605665 -1.38436 0.007695 -1.69279 0.15223 -1.26584 0.018926 -1.54786

Pttg1ip pituitary tumor-transforming 1 interacting protein0.0191513 1.6105 0.498751 1.12237 0.653767 -1.07885 0.027837 -1.54806

Ppp6r1 protein phosphatase 6, regulatory subunit 10.386994 1.12913 0.088122 -1.29401 0.674377 -1.05958 0.010981 -1.54815

Kab KARP-1 binding protein 10.0005075 1.79664 0.024862 1.33379 0.219738 -1.14934 0.003076 -1.54819

RGD1309995similar to CG13957-PA 0.141796 -1.29886 0.044529 -1.46505 0.083808 -1.37263 0.026063 -1.54827

Tlk1 tousled-like kinase 1 0.0022086 -1.5142 3.53E-05 -2.16501 0.417554 -1.08342 0.001605 -1.54907

Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 42.04E-05 3.33084 1.06E-05 3.72344 0.003626 -1.73329 0.011901 -1.55053

Serpinb11 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 110.0004165 1.93606 0.009477 1.47394 0.184461 -1.18072 0.004971 -1.55091

of 148Diabetes

Arpp19 cAMP-regulated phosphoprotein 190.0511864 1.46763 0.193376 1.26845 0.118148 -1.34063 0.030582 -1.55114

Ly6b lymphocyte antigen 6 complex, locus B0.0240347 -5.47199 0.02287 -5.58092 0.512663 -1.52087 0.493619 -1.55114

Stfa3 stefin A3 1.36E-05 44.3945 9.25E-06 54.2984 0.151662 -1.89718 0.308929 -1.55114

Dock11 dedicator of cytokinesis 110.0022681 1.49282 0.587455 -1.05274 0.89291 1.01272 0.001301 -1.55181

Rai14 retinoic acid induced 14 4.91E-06 3.2398 0.000124 2.12675 0.866889 -1.0191 0.003818 -1.55245

Zdhhc9 zinc finger, DHHC-type containing 90.011344 1.34901 0.125103 1.16973 0.011722 -1.3463 0.001344 -1.55264

Dlg1 discs, large homolog 1 (Drosophila)0.0029222 -1.66528 0.000146 -2.25979 0.296644 -1.14451 0.006574 -1.5531

Atg12 ATG12 autophagy related 12 homolog (S. cerevisiae)0.0027821 -1.73492 0.000462 -2.08816 0.08429 -1.29068 0.00934 -1.55347

Tubb3 tubulin, beta 3 0.120136 2.09962 0.146083 1.98675 0.392698 -1.46995 0.331821 -1.55347

Defb1 defensin beta 1 0.317682 -1.18674 0.050839 -1.44596 0.168928 -1.27501 0.025374 -1.55351

Senp5 Sumo1/sentrin/SMT3 specific peptidase 50.974496 1.03056 0.6271 -1.58555 0.957379 1.0516 0.642068 -1.55382

Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 10.0001483 2.95964 0.001381 2.16351 0.451527 -1.13613 0.025672 -1.55421

Gdpd1 glycerophosphodiester phosphodiesterase domain containing 10.684888 -1.08173 0.194564 -1.30246 0.208269 -1.29108 0.045697 -1.55452

Ssu72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)0.956369 -1.00606 0.06104 -1.26272 0.080747 -1.23862 0.003345 -1.5546

Gucy1b3 guanylate cyclase 1, soluble, beta 30.0057799 1.59057 0.933017 1.01085 0.92517 1.01213 0.007539 -1.55464

Elk3 ELK3, member of ETS oncogene family2.10E-06 2.45573 0.00019 1.62373 0.720671 -1.02804 0.000357 -1.55481

RGD1305713similar to RIKEN cDNA 3110040N110.327984 -1.26937 0.077949 -1.58837 0.369973 -1.24295 0.089851 -1.55532

Cyp4f17 cytochrome P450, family 4, subfamily f, polypeptide 170.125602 -1.11766 0.00037 -1.46588 0.030587 -1.1859 0.000139 -1.55538

MGC95152 similar to B230212L03Rik protein0.0004476 -2.49926 2.11E-05 -4.12789 0.71779 1.06188 0.024863 -1.5554

RGD1308117similar to 9930012K11Rik protein0.148998 1.1487 0.000756 -1.58002 0.114478 1.16623 0.000937 -1.55626

Snap29 synaptosomal-associated protein 290.960233 -1.006 0.123236 -1.22162 0.065078 -1.28187 0.005175 -1.55663

Pak1 p21 protein (Cdc42/Rac)-activated kinase 13.32E-06 3.19979 4.73E-05 2.25259 0.396783 -1.09626 0.002565 -1.55723

Pxdn peroxidasin homolog (Drosophila)0.0039047 4.40571 0.019899 2.92357 0.930959 -1.03363 0.265246 -1.55764

Dusp5 dual specificity phosphatase 50.0144951 1.82418 0.175558 -1.33304 0.050298 1.56099 0.051134 -1.5578

NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like5.13E-06 -2.89176 5.01E-07 -4.21906 0.527185 -1.06783 0.002095 -1.55795

Atp2c1 ATPase, Ca++ transporting, type 2C, member 10.0077587 -1.42721 0.000208 -1.90728 0.165758 -1.16624 0.002285 -1.55852

Ppap2b phosphatidic acid phosphatase type 2B6.54E-07 -3.4613 1.05E-07 -4.80843 0.230104 -1.12204 0.001043 -1.55873


RGD1563941similar to hypothetical protein FLJ200100.836478 1.03254 0.59614 -1.0864 0.059614 -1.39009 0.018192 -1.55934

Sp110 SP110 nuclear body protein0.0397718 -1.48832 0.031741 -1.52369 0.031787 -1.52346 0.025394 -1.55966

Atp11c-ps1 ATPase, class VI, type 11C, pseudogene 10.49246 -1.08324 0.139211 -1.20026 0.015214 -1.40765 0.003958 -1.55971

Mtx1 Metaxin 1 0.167036 -1.09936 1.92E-05 -1.74782 0.7687 1.01914 9.85E-05 -1.56

Vsig10l V-set and immunoglobulin domain containing 10 like0.0540391 1.38067 0.18671 1.22932 0.050508 -1.38924 0.014409 -1.56029

Isg20 interferon stimulated exonuclease gene 200.0004001 1.65489 0.019403 1.28762 0.055235 -1.21454 0.000888 -1.56096

Cttnbp2nl CTTNBP2 N-terminal like 0.617 -1.06418 0.011956 -1.4724 0.342197 -1.12832 0.005828 -1.56115

of 148 Diabetes

Nedd9 neural precursor cell expressed, developmentally down-regulated 95.51E-05 15.4187 0.000182 10.0441 0.962357 -1.01735 0.242444 -1.56173

Trappc6a trafficking protein particle complex 6A1.36E-05 -2.17392 5.59E-07 -3.26307 0.639177 -1.04113 0.000649 -1.56275

PCOLCE2 procollagen C-endopeptidase enhancer 20.0018601 -2.15578 7.36E-05 -3.50333 0.823446 1.03964 0.02929 -1.56313

Ssr3 signal sequence receptor, gamma0.945555 -1.00762 0.03385 -1.31726 0.135655 -1.19586 0.003232 -1.56333

Rb1cc1 RB1-inducible coiled-coil 10.600288 -1.0537 0.005529 -1.43439 0.186879 -1.14846 0.001624 -1.56338

Grip1 glutamate receptor interacting protein 12.23E-05 2.47784 0.000438 1.80871 0.236895 -1.1413 0.002534 -1.56352

Zfp317 zinc finger protein 317 0.0003459 -1.83047 5.94E-05 -2.18155 0.028465 -1.31196 0.002313 -1.5636

Tmed5 transmembrane emp24 protein transport domain containing 50.125861 1.22532 0.341227 -1.12786 0.329001 -1.13156 0.005544 -1.5638

Cdadc1 cytidine and dCMP deaminase domain containing 10.0044875 -1.44504 0.000281 -1.78061 0.035114 -1.26936 0.001445 -1.56413

Rufy1 RUN and FYVE domain containing 10.0002614 -1.49386 9.32E-06 -1.89661 0.012207 -1.2322 0.000124 -1.56441

Lhfpl2 lipoma HMGIC fusion partner-like 26.86E-08 5.88996 1.19E-07 5.22269 0.008526 -1.38835 0.001478 -1.56573

Acbd3 acyl-Coenzyme A binding domain containing 30.348026 -1.11022 0.001134 -1.679 0.746548 -1.03572 0.002694 -1.56633

LOC682225 similar to zinc finger protein 6650.38502 -1.19186 0.054527 -1.53702 0.338364 -1.21469 0.046694 -1.56647

Duox2 dual oxidase 2 0.951445 -1.01476 0.246043 -1.3391 0.482447 -1.18746 0.090362 -1.567

Glipr1 GLI pathogenesis-related 10.0102647 1.82317 0.041603 1.5467 0.152181 -1.32943 0.037141 -1.56707

Asb14 ankyrin repeat and SOCS box-containing 140.005176 1.48504 0.92738 -1.00981 0.680325 -1.04539 0.002513 -1.56768

Fam63b family with sequence similarity 63, member B0.391525 1.15078 0.495349 -1.11712 0.236078 -1.21972 0.019859 -1.56803

Mcee methylmalonyl CoA epimerase0.0001172 -2.14967 7.71E-06 -3.04566 0.382946 -1.10683 0.003477 -1.56816

Tsc22d1 TSC22 domain family, member 10.452152 1.19445 0.105606 -1.50698 0.557669 1.14746 0.080206 -1.5687

CPNE3 copine III 1.28E-05 -2.89363 1.92E-06 -3.92087 0.227933 -1.15783 0.00388 -1.56885

Cd1d1 CD1d1 molecule 2.43E-05 3.09304 0.002433 1.76273 0.415786 1.11821 0.008561 -1.56919

Fstl3 follistatin-like 3 (secreted glycoprotein)0.0235667 1.71816 0.673853 1.08843 0.97636 1.00595 0.048732 -1.56924

Ccpg1 cell cycle progression 10.0001937 -2.02121 8.92E-06 -2.9447 0.512544 -1.07735 0.003225 -1.56959

Vapb VAMP (vesicle-associated membrane protein)-associated protein B and C0.413514 1.14928 0.415175 1.14868 0.023409 -1.56945 0.023294 -1.57026

Rnf19b ring finger protein 19B 0.0002972 2.45407 0.03405 1.45806 0.65205 1.07164 0.01569 -1.57058

Lmo2 LIM domain only 2 0.0068089 -1.71851 0.002794 -1.88958 0.04421 -1.429 0.016589 -1.57125

Ggps1 geranylgeranyl diphosphate synthase 10.486245 -1.09668 0.012657 -1.4982 0.300196 -1.15032 0.007237 -1.57148

RGD1563222similar to RIKEN cDNA A930018P220.0844429 -1.23848 0.00233 -1.61023 0.117995 -1.20951 0.00313 -1.57256

Fam135a family with sequence similarity 135, member A0.000531 -1.93713 0.000112 -2.29899 0.045039 -1.32564 0.005129 -1.57327

Cldnd1 Claudin domain containing 10.0018014 -1.76924 0.000292 -2.13583 0.066129 -1.30333 0.006604 -1.57338

Scgb1c1 secretoglobin, family 1C, member 10.0613182 1.38528 0.340906 1.16382 0.099508 -1.32192 0.016424 -1.57346

Ift46 intraflagellar transport 46 homolog (Chlamydomonas)0.0312162 -1.37159 0.000363 -2.04311 0.661947 -1.05653 0.005677 -1.5738

Pank2 pantothenate kinase 2 (Hallervorden-Spatz syndrome)0.135304 1.24729 0.265364 1.17272 0.018511 -1.48005 0.009218 -1.57416

Nedd9 neural precursor cell expressed, developmentally down-regulated 90.0001755 6.65889 0.001328 4.01771 0.864863 1.05206 0.154137 -1.57538

Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, syste0.276963 1.20331 0.013616 -1.64804 0.185835 1.2581 0.020879 -1.57627

of 148Diabetes

Cpped1 calcineurin-like phosphoesterase domain containing 10.000249 -1.73011 1.83E-05 -2.209 0.04298 -1.23513 0.000839 -1.57701

Zcchc6 zinc finger, CCHC domain containing 60.116891 -1.22687 0.001517 -1.73021 0.363522 -1.11861 0.004428 -1.57754

XIAP X-linked inhibitor of apoptosis3.65E-05 -1.72076 8.57E-07 -2.44802 0.154668 -1.10964 0.000125 -1.57861

Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cyt0.843823 1.01973 0.002736 -1.50639 0.781653 -1.02791 0.001432 -1.57898


B3galnt1 beta-1,3-N-acetylgalactosaminyltransferase 11.77E-08 7.49367 7.44E-07 3.48202 0.00913 1.36263 0.000993 -1.57938

Ccndbp1 cyclin D-type binding-protein 10.0723721 -1.3141 0.001291 -1.89421 0.507997 -1.0958 0.008541 -1.57955

LOC497860 similar to RIKEN cDNA 4930517K110.404739 1.82267 0.269793 2.24606 0.357681 -1.94657 0.521792 -1.57964

Zdhhc14 zinc finger, DHHC-type containing 148.13E-09 14.733 3.45E-08 9.39166 0.950694 -1.00702 0.00312 -1.57974

Abat 4-aminobutyrate aminotransferase6.00E-05 2.63261 0.001446 1.82359 0.495552 -1.09451 0.006815 -1.58008

Eaf2 ELL associated factor 2 0.0608563 1.34725 0.036279 -1.40972 0.215564 1.20186 0.010127 -1.58026

FSTL1 follistatin-like 1 6.52E-10 52.3175 2.25E-09 29.5573 0.36301 1.11982 0.004531 -1.58064

Elk3 ELK3, member of ETS oncogene family0.0003934 2.11429 0.028296 1.40963 0.690153 -1.05457 0.007316 -1.58174

Gcat glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)0.0198953 -1.40851 0.000759 -1.86263 0.165662 -1.19744 0.004601 -1.5835

Arg1 arginase, liver 0.11226 -1.40571 0.003991 -2.14284 0.844776 -1.03936 0.042455 -1.58438

Slpi secretory leukocyte peptidase inhibitor0.37453 -1.34127 0.061069 -1.97381 0.818909 -1.07667 0.178704 -1.58443

Cish cytokine inducible SH2-containing protein0.918431 -1.0093 0.15924 -1.14567 0.005166 -1.39622 0.000768 -1.58486

Cxadr coxsackie virus and adenovirus receptor0.0775999 -1.33584 0.011055 -1.6007 0.086381 -1.32267 0.012262 -1.58492

RGD1563945Similar to mKIAA0215 protein8.62E-06 3.50889 6.53E-05 2.58925 0.248101 -1.16966 0.006385 -1.5851

Ivl involucrin 0.0001828 1.98616 0.115419 1.20399 0.717115 1.04026 0.002331 -1.5858

Pdpn podoplanin 3.23E-10 194.914 6.71E-10 122.676 0.99007 1.00184 0.012195 -1.58593

Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A1.65E-07 26.9941 5.94E-08 42.7112 0.0016 -2.50945 0.04729 -1.58601

Ip6k2 inositol hexakisphosphate kinase 20.0007234 1.58952 0.091782 -1.1821 0.088545 1.1845 0.000744 -1.58629

Nsun4 NOL1/NOP2/Sun domain family, member 40.0766856 1.23192 0.175326 1.16495 0.004214 -1.5007 0.002007 -1.58697

Mtus1 mitochondrial tumor suppressor 10.0001873 -2.63845 8.89E-06 -4.40384 0.744096 1.0517 0.014748 -1.58704

Ly96 Lymphocyte antigen 96 0.427575 1.10256 0.08165 1.26189 0.000917 -1.81693 0.004201 -1.58752

Parp8 poly (ADP-ribose) polymerase family, member 80.0004061 2.29752 0.000157 2.605 0.003453 -1.79999 0.012213 -1.58753

Rab40b Rab40b, member RAS oncogene family0.0001955 -3.55319 5.46E-05 -4.57753 0.317521 -1.23258 0.046144 -1.58792

LOC100362940 /// LOC100364126sorting nexin 21-like /// sorting nexin 21-like2.49E-06 -2.37084 2.70E-07 -3.16485 0.045498 -1.18956 0.000232 -1.58795

Hbegf heparin-binding EGF-like growth factor0.374927 1.19703 0.103338 -1.42168 0.728101 1.07136 0.042004 -1.58845

Cebpd CCAAT/enhancer binding protein (C/EBP), delta0.0003526 2.08237 0.000364 2.07528 0.005958 -1.58319 0.005727 -1.5886

Gcom1 GRINL1A complex locus 0.993116 -1.00134 0.039174 -1.44642 0.540478 -1.10057 0.014827 -1.58977

Synj2bp synaptojanin 2 binding protein3.16E-05 -2.27232 1.79E-06 -3.33741 0.441453 -1.0827 0.001487 -1.59019

Cfh complement factor H 0.0057857 3.27005 0.108415 1.77516 0.655894 1.15832 0.18223 -1.59034

Penk proenkephalin 0.0036113 2.33109 0.138593 1.40852 0.85345 1.04053 0.056417 -1.59054

of 148 Diabetes

Chst10 carbohydrate sulfotransferase 100.517991 1.23889 0.655941 1.15785 0.245901 -1.48686 0.180916 -1.59092

Ccnl2 cyclin L2 0.100145 1.19466 0.197485 -1.14397 0.150799 -1.16419 0.001267 -1.59104

Sh3kbp1 SH3-domain kinase binding protein 12.38E-05 3.0013 0.00058 2.00168 0.649613 -1.06145 0.006247 -1.59153

Pik3c2g phosphoinositide-3-kinase, class 2, gamma polypeptide0.0007514 -3.64772 0.002402 -2.91715 0.022973 -1.99086 0.094629 -1.59213

Plat plasminogen activator, tissue0.248041 1.33872 0.773092 -1.07233 0.669139 -1.10943 0.082062 -1.59265


Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (Ga4.40E-06 2.93517 6.66E-05 2.10416 0.212537 -1.14298 0.001485 -1.59439

Stau2 staufen, RNA binding protein, homolog 2 (Drosophila)6.01E-05 3.31853 0.002114 2.01171 0.833701 1.03459 0.017707 -1.59445

DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.1466 -1.1959 0.005653 -1.51729 0.073602 -1.25735 0.00301 -1.59526

Odz4 odd Oz/ten-m homolog 4 (Drosophila)3.95E-09 13.1753 1.28E-08 9.22583 0.281531 -1.11713 0.001241 -1.59536

Fam135a family with sequence similarity 135, member A0.0421864 -1.3464 0.010126 -1.5102 0.021134 -1.42237 0.005292 -1.59541

Znf655 zinc finger protein 655 0.259273 1.20911 0.737967 -1.05567 0.189314 -1.2515 0.017195 -1.59744

Gtdc1 glycosyltransferase-like domain containing 10.0009617 -1.53491 0.000465 -1.61567 0.001137 -1.51759 0.000544 -1.59744

MFAP3L microfibrillar-associated protein 3-like2.25E-05 -2.73692 2.24E-06 -3.93685 0.387856 -1.11057 0.003542 -1.59747

Ptn pleiotrophin 0.0283374 1.55583 0.199317 1.26059 0.157174 -1.29479 0.022073 -1.59804

Pptc7 PTC7 protein phosphatase homolog (S. cerevisiae)0.704959 1.08272 0.43237 1.18224 0.025085 -1.74499 0.049294 -1.5981

Expi extracellular proteinase inhibitor5.37E-05 7.19221 0.0008 3.76435 0.501631 1.19554 0.101935 -1.59812

Fstl1 follistatin-like 1 9.66E-10 31.245 3.28E-09 19.117 0.841502 1.0224 0.002363 -1.59861


Sox4 SRY (sex determining region Y)-box 40.0056667 2.0802 0.149443 1.36605 0.808707 -1.05016 0.043158 -1.59918

Aldoc aldolase C, fructose-bisphosphate0.0748319 1.21161 0.021398 -1.30663 0.916807 -1.01016 0.001043 -1.5992

Phldb2 pleckstrin homology-like domain, family B, member 23.64E-05 2.62896 3.62E-05 2.63079 0.003992 -1.60051 0.004025 -1.5994

Blnk B-cell linker 0.0004286 2.34007 5.54E-05 3.13966 0.000857 -2.1462 0.013044 -1.59962

Copz2 coatomer protein complex, subunit zeta 27.65E-06 2.26329 0.000225 1.6655 0.076728 -1.17774 0.000388 -1.60046

Tmem45a transmembrane protein 45A0.0087934 2.05884 0.008417 2.07172 0.052628 -1.61103 0.055127 -1.60102

Ispd isoprenoid synthase domain containing0.0069718 -1.66866 0.009092 -1.62619 0.008124 -1.64397 0.010621 -1.60213

Mmp9 matrix metallopeptidase 94.24E-05 100.915 0.000175 43.5838 0.539611 1.44498 0.435576 -1.60239

Epdr1 ependymin related protein 1 (zebrafish)0.219594 -1.27442 0.260451 1.24668 0.000893 -2.54597 0.03212 -1.60245

Vps41 vacuolar protein sorting 41 homolog (S. cerevisiae)0.001275 -1.66062 0.000274 -1.90279 0.012486 -1.39861 0.001981 -1.60257

Scaper S-phase cyclin A-associated protein in the ER0.0004128 -1.77144 2.78E-06 -3.14692 0.328043 1.10847 0.001408 -1.60264

Olfm1 olfactomedin 1 0.0690007 1.82495 0.764369 1.09294 0.890116 1.04171 0.138249 -1.60291


Arid5b AT rich interactive domain 5B (Mrf1 like)0.193395 1.14852 0.003333 -1.49485 0.50144 1.07106 0.001291 -1.60296

Pcdhb19 protocadherin beta 19 0.927037 -1.01181 0.028715 -1.39207 0.253501 -1.1652 0.005252 -1.6031

Egr1 early growth response 10.0005608 15.0751 0.003945 7.14622 0.593458 1.31426 0.363913 -1.60511

of 148Diabetes

Apobec1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.264551 -1.43871 0.050799 -2.00583 0.65444 -1.15134 0.157167 -1.60518

Col8a2 Collagen, type VIII, alpha 20.000268 2.45332 0.109742 1.29906 0.296227 1.17648 0.011632 -1.60524

Chmp1b chromatin modifying protein 1B0.826787 -1.02331 0.002911 -1.53759 0.532821 -1.06868 0.001651 -1.60576

Mut methylmalonyl-Coenzyme A mutase0.163058 -1.16781 0.007365 -1.43311 0.028562 -1.30888 0.001556 -1.60623

Zcchc24 zinc finger, CCHC domain containing 240.0001576 2.21832 0.015276 1.44355 0.719532 -1.04544 0.004127 -1.60655

Ptpn4 protein tyrosine phosphatase, non-receptor type 40.0358961 -1.42526 0.000149 -2.57625 0.427312 1.12486 0.00977 -1.60693

RGD1564541Similar to hypothetical protein FLJ229650.0061516 -1.85338 0.005149 -1.89232 0.026603 -1.57406 0.02196 -1.60714

Ift172 intraflagellar transport 172 homolog (Chlamydomonas)0.043643 1.43916 0.191006 1.24274 0.062906 -1.38877 0.014155 -1.60828

Fry furry homolog (Drosophila)0.0067472 2.05237 0.026249 1.71549 0.173754 -1.34483 0.043397 -1.60891

Lhfpl2 lipoma HMGIC fusion partner-like 29.10E-07 4.09491 8.41E-06 2.86252 0.295415 -1.12479 0.001929 -1.60904

Myo1b myosin Ib 0.0281026 1.38672 0.907764 -1.01472 0.304248 -1.14353 0.004588 -1.60911

Iffo2 intermediate filament family orphan 20.010567 1.74752 0.487464 1.13025 0.815708 -1.04135 0.022105 -1.61008

Arl4a ADP-ribosylation factor-like 4A2.07E-05 3.34645 0.001387 1.91885 0.574278 1.08308 0.008135 -1.61021

STRN striatin, calmodulin binding protein0.544954 -1.04344 0.204201 -1.09747 0.000225 -1.53121 0.000104 -1.61049

Leprel2 leprecan-like 2 0.454268 1.14773 0.919326 1.01848 0.07555 -1.4299 0.026128 -1.61136

Fam82a1 family with sequence similarity 82, member A10.0001737 -2.10227 1.67E-05 -2.80503 0.133148 -1.2079 0.0029 -1.61168

LOC100910786uncharacterized LOC1009107860.487332 -1.17263 0.053177 -1.64175 0.537605 -1.15126 0.06063 -1.61184

RGD1310110similar to 3632451O06Rik protein0.0015578 2.93585 0.028522 1.84422 0.956565 -1.01298 0.070931 -1.61259

Tusc4 tumor suppressor candidate 40.0083427 -1.74228 0.001342 -2.15427 0.134502 -1.30442 0.017213 -1.61287

Impad1 inositol monophosphatase domain containing 14.51E-06 2.23913 3.57E-06 2.29647 0.000139 -1.65422 0.000198 -1.61291

Nebl Nebulette 0.17701 -1.17084 0.000114 -2.10487 0.338346 1.11458 0.002036 -1.61292

Tmem117 transmembrane protein 1172.27E-08 5.62785 1.27E-07 4.00338 0.124535 -1.14752 0.000337 -1.61316

Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A0.4741 1.15877 0.020831 -1.75601 0.271315 1.26087 0.040597 -1.61381

LOC363458 similar to procollagen, type IV, alpha 62.34E-05 2.48102 0.011729 1.40306 0.407696 1.09537 0.00177 -1.61433

RGD1566359similar to RIKEN cDNA B230219D220.0588026 -1.27205 0.000314 -1.9322 0.592082 -1.06288 0.002338 -1.61447

RGD1566359similar to RIKEN cDNA B230219D220.0588026 -1.27205 0.000314 -1.9322 0.592082 -1.06288 0.002338 -1.61447

Clca4l chloride channel calcium activated 4-like0.191801 -1.51565 0.002668 -3.49027 0.25845 1.42597 0.138976 -1.61492

Pdcd6ip programmed cell death 6 interacting protein5.21E-07 -1.89177 1.67E-08 -2.68974 0.020307 -1.13604 4.60E-06 -1.61524


MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)0.0001801 -1.85963 1.63E-05 -2.38367 0.040351 -1.26078 0.000976 -1.61607

Mesdc2 mesoderm development candidate 20.632705 -1.09012 0.296912 -1.21386 0.064111 -1.45189 0.024462 -1.61669

Aass aminoadipate-semialdehyde synthase2.01E-05 4.92298 0.000336 2.90927 0.805957 1.04651 0.027753 -1.61696

Mxd4 Max dimerization protein 40.60643 -1.07193 0.005397 -1.63163 0.652207 -1.06252 0.00595 -1.61731

Dd25 hypothetical protein Dd259.58E-07 -4.27223 2.85E-07 -5.46733 0.06379 -1.26388 0.002244 -1.61744

Nppb natriuretic peptide precursor B7.11E-05 60.4136 0.000102 49.2568 0.62732 -1.31919 0.406146 -1.61799

of 148 Diabetes

Cpm carboxypeptidase M 0.0724223 -1.44459 0.024317 -1.63645 0.079864 -1.42849 0.026806 -1.61821

Spin2a spindlin family, member 2A0.0997258 -1.43176 0.01575 -1.80161 0.228182 -1.28612 0.037137 -1.61834

Col7a1 procollagen, type VII, alpha 10.0055757 1.93349 0.90186 1.02259 0.402166 1.16799 0.025286 -1.61883

Nr4a2 nuclear receptor subfamily 4, group A, member 20.540239 -1.21109 0.007434 -2.90051 0.227169 1.47939 0.14626 -1.61889

LOC681825 similar to Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VHL-binding prote0.940008 -1.00884 0.382358 -1.11045 0.009209 -1.47201 0.00277 -1.62028

Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon isoform0.0003301 -2.18725 8.77E-05 -2.5837 0.042148 -1.3717 0.006143 -1.62033

Abca8 ATP-binding cassette, sub-family A (ABC1), member 86.81E-07 -5.11985 1.56E-07 -7.2021 0.262097 -1.15187 0.003352 -1.62035

RGD1562885similar to RIKEN cDNA 2300002M231.07E-05 24.0223 2.81E-05 16.2455 0.786967 -1.09598 0.179149 -1.62063

Zdhhc4 zinc finger, DHHC-type containing 40.0060063 -1.51138 0.000586 -1.84282 0.034041 -1.32924 0.00251 -1.62074

LOC100909490uncharacterized LOC1009094905.03E-06 -3.58364 3.88E-06 -3.74684 0.006194 -1.55016 0.003649 -1.62076

Tmsbl1 thymosin beta-like protein 10.000251 2.89077 0.003433 2.01119 0.50037 -1.12777 0.021975 -1.621

Vsnl1 visinin-like 1 0.0001442 5.79313 0.000221 5.21297 0.184471 -1.45884 0.100213 -1.6212

Cib2 calcium and integrin binding family member 20.574966 1.08591 0.104944 -1.29401 0.338825 -1.15421 0.008957 -1.62188

F2rl1 coagulation factor II (thrombin) receptor-like 19.15E-05 2.9923 0.0008 2.21195 0.26599 -1.19934 0.012923 -1.62245

Mrc2 mannose receptor, C type 20.0002022 3.91369 0.002343 2.53356 0.821251 -1.05078 0.051812 -1.62318

LOC305633 similar to Antxr2 protein4.90E-06 22.8538 7.95E-06 18.7973 0.348647 -1.33577 0.133987 -1.62404

RGD1303142oxidative stress responsive gene0.205168 -1.16989 0.000673 -1.84121 0.787399 -1.03224 0.002743 -1.62457

Chst14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 140.0001149 2.5124 0.002221 1.7925 0.295427 -1.15922 0.006241 -1.62478

Ace2 Angiotensin I converting enzyme (peptidyl-dipeptidase A) 20.0016191 1.52888 0.668604 -1.04129 0.826161 -1.02088 0.0007 -1.62525

Txndc16 thioredoxin domain containing 160.0001026 -2.71258 3.55E-05 -3.18379 0.048999 -1.38569 0.008597 -1.6264

Lpar1 lysophosphatidic acid receptor 15.08E-06 -3.30726 2.65E-07 -5.79975 0.521902 1.07767 0.002415 -1.62726

Gas7 growth arrest specific 70.0001905 2.82319 0.001339 2.15841 0.209013 -1.24429 0.015948 -1.62752

MGC125239 hypothetical protein LOC6861790.0320426 1.22825 0.0164 -1.27137 0.613788 -1.04253 0.000276 -1.62799

Moxd1 monooxygenase, DBH-like 10.0072611 -1.62537 0.006304 -1.64706 0.008204 -1.607 0.007115 -1.62845

Lcp2 lymphocyte cytosolic protein 20.004787 1.83045 0.101014 1.3364 0.300884 -1.18896 0.01431 -1.62851

Ubp1 upstream binding protein 1 (LBP-1a)0.0002675 -1.81113 5.46E-06 -2.7748 0.541959 -1.06321 0.000965 -1.62892

Hist2h2aa3 histone cluster 2, H2aa30.0434622 1.54323 0.678404 -1.08103 0.899138 1.02398 0.027278 -1.62921

Nap1l3 nucleosome assembly protein 1-like 39.78E-05 -2.31504 6.06E-06 -3.41934 0.427545 -1.10321 0.00319 -1.62945

Peli3/LOC689200pellino 3 [Rattus norvegicus0.357069 1.17595 0.426302 -1.14912 0.291647 -1.2059 0.018588 -1.62955

Lhfpl2 lipoma HMGIC fusion partner-like 27.98E-06 3.00649 0.000243 1.98089 0.528168 -1.07464 0.002053 -1.63103

Il1a interleukin 1 alpha 0.734681 -1.14659 0.843419 -1.08277 0.198003 -1.72826 0.244273 -1.63207

Inhbb inhibin beta-B 6.86E-07 50.0897 3.51E-06 23.5867 0.376428 1.30115 0.119552 -1.63212

Oas1a 2'-5' oligoadenylate synthetase 1A0.012346 -2.89388 0.001412 -4.83736 0.944373 1.02409 0.176597 -1.63227

SCARB2 scavenger receptor class B, member 20.388739 1.10059 0.631079 -1.0539 0.011699 -1.40748 0.001622 -1.63256

Efna1 ephrin A1 0.0128369 1.73777 0.573912 1.10694 0.825206 -1.04035 0.02214 -1.63322

of 148Diabetes

RGD1564804similar to chromosome 1 open reading frame 500.670453 1.06707 0.393924 -1.1416 0.081165 -1.34075 0.010271 -1.63326

LOC100151767hypothetical LOC1001517670.141755 -1.20778 0.003148 -1.61975 0.127112 -1.21794 0.002852 -1.63338

Tpm1 Tropomyosin 1, alpha 0.0034205 3.0615 0.029348 2.05854 0.73759 -1.09921 0.109115 -1.63477

Pmf31 PMF32 protein 0.902109 -1.01442 0.006505 -1.50906 0.423884 -1.09969 0.002398 -1.63591

Igfbp3 insulin-like growth factor binding protein 30.00018 21.4908 0.00057 13.218 0.989252 -1.00654 0.32422 -1.6365

Lox lysyl oxidase 0.0101967 1.76708 0.894577 1.02357 0.762565 1.0547 0.020111 -1.63685

Thnsl1 threonine synthase-like 1 (S. cerevisiae)0.0001587 2.18201 0.004814 1.5714 0.197223 -1.17905 0.002958 -1.6372

LOC100360898 /// Mxi1Max interactor 1-like /// MAX interactor 10.174283 -1.21201 0.000629 -2.0121 0.917452 1.01389 0.005062 -1.63739

Glrx2 glutaredoxin 2 0.0449553 -1.62012 0.006611 -2.09448 0.277265 -1.26736 0.04124 -1.63843

Mat2a methionine adenosyltransferase II, alpha0.897201 1.02622 0.278461 -1.25312 0.245634 -1.27525 0.034232 -1.63994

Pparg peroxisome proliferator-activated receptor gamma3.46E-06 -8.84964 1.71E-06 -10.9401 0.182172 -1.32667 0.03381 -1.64007

Coa5 cytochrome C oxidase assembly factor 50.195897 -1.20886 0.014734 -1.51631 0.080967 -1.3078 0.006199 -1.64042

Mga MAX gene associated 0.0006116 -1.77317 1.70E-05 -2.60567 0.325258 -1.11653 0.001526 -1.64074

Sik1 salt-inducible kinase 1 0.42564 -1.21105 0.006915 -2.27686 0.56787 1.14556 0.061663 -1.64119

Baz1a bromodomain adjacent to zinc finger domain, 1A0.0985571 -1.13325 0.00021 -1.53434 0.019583 -1.21504 7.35E-05 -1.64507

Qsox1 quiescin Q6 sulfhydryl oxidase 12.65E-06 3.11033 9.21E-05 2.01487 0.529028 -1.06608 0.000904 -1.64569

Gabarapl1 GABA(A) receptor-associated protein like 10.0015314 -1.82075 5.32E-05 -2.69447 0.427525 -1.11232 0.004461 -1.64609

Samd8 sterile alpha motif domain containing 80.0616899 1.32651 0.732776 1.04709 0.078674 -1.29979 0.004999 -1.64664

Znf655 zinc finger protein 655 0.0976105 1.18294 0.74008 -1.03125 0.010065 -1.35014 0.000529 -1.64705

Falz fetal Alzheimer antigen0.0068037 -1.41007 9.59E-05 -1.97443 0.125709 -1.17631 0.00077 -1.64712

Cpne8 copine VIII 0.0011437 -1.70603 9.19E-06 -2.91887 0.736428 1.03846 0.001729 -1.64755

Stx2 syntaxin 2 0.0577484 1.43628 0.990133 1.00209 0.418062 -1.14986 0.015709 -1.64807

Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 10.0022281 -2.41287 0.000352 -3.25602 0.345126 -1.22134 0.036547 -1.64812

Tram1 Translocation associated membrane protein 10.372233 -1.25591 0.048453 -1.75203 0.508416 -1.1816 0.071879 -1.64836

LOC302495 hypothetical LOC3024950.943996 1.00738 0.008847 -1.41754 0.192964 -1.15518 0.001146 -1.64961

Clec4a3 C-type lectin domain family 4, member a30.0059109 3.0738 0.079323 1.83563 0.962347 1.01483 0.136111 -1.65005

Ralgps2 Ral GEF with PH domain and SH3 binding motif 20.215265 -1.24869 0.003009 -1.99897 0.85779 -1.03101 0.016155 -1.65049

Swt1 Swt1 RNA endoribonuclease homolog (S. cerevisiae)0.0127043 -1.41209 0.000304 -1.92304 0.11194 -1.21273 0.001654 -1.65154

Znf655 zinc finger protein 655 0.123903 -1.23656 0.066438 -1.29992 0.006414 -1.57126 0.003617 -1.65177

Accn1 amiloride-sensitive cation channel 1, neuronal0.0014923 1.99712 0.073677 1.35142 0.466391 -1.11845 0.00892 -1.65284

Ckap4 cytoskeleton-associated protein 40.197376 1.12398 0.006179 -1.3584 0.36789 -1.08256 0.000308 -1.65288

Aif1 allograft inflammatory factor 10.000877 6.6592 0.00724 3.73151 0.840561 1.07955 0.209514 -1.65308

Pon3 paraoxonase 3 0.461649 -1.15168 0.153282 -1.33398 0.087305 -1.42723 0.024973 -1.65315

Rgs1 regulator of G-protein signaling 10.116548 1.96646 0.506053 1.30678 0.812144 -1.09901 0.226906 -1.65381

LOC689755 hypothetical protein LOC6897550.0633788 1.34589 0.972202 1.00497 0.163193 -1.23586 0.00646 -1.65511

of 148 Diabetes

Eif4e3 eukaryotic translation initiation factor 4E member 30.001026 2.02818 0.036771 1.42267 0.31697 -1.16222 0.007136 -1.65688

Wasf2 WAS protein family, member 20.0816011 -1.35924 0.002525 -1.94802 0.373431 -1.15638 0.011227 -1.65729

Lpar1 lysophosphatidic acid receptor 10.000181 -3.11883 8.55E-06 -5.68855 0.599089 1.09992 0.019693 -1.65825

Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.729628 -1.05582 0.012616 -1.62506 0.634749 -1.0778 0.010298 -1.6589

Ppm1l protein phosphatase 1 (formerly 2C)-like8.15E-06 3.66406 0.000368 2.13806 0.808288 1.03292 0.004417 -1.65911

Enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 40.106959 1.29736 0.881737 -1.02227 0.156823 -1.25109 0.007713 -1.65925

Rdx radixin 0.0294191 -1.80416 0.001475 -2.87377 0.855135 -1.04294 0.05237 -1.66126


Kitlg KIT ligand 0.0001817 2.86121 0.005058 1.85038 0.664733 -1.07508 0.013426 -1.66237

Pdlim5 PDZ and LIM domain 5 0.0376198 1.41414 0.78909 -1.03927 0.402102 -1.13112 0.006497 -1.66238

Cmtm8 CKLF-like MARVEL transmembrane domain containing 82.62E-05 2.76938 0.000152 2.21521 0.042813 -1.3303 0.002661 -1.66309

Stk16 serine/threonine kinase 160.331691 1.11418 0.729061 -1.03825 0.008408 -1.43818 0.001248 -1.66368

Emp1 epithelial membrane protein 10.023384 -1.48538 0.002566 -1.84183 0.071389 -1.34195 0.007015 -1.66398

Il7 interleukin 7 9.84E-08 5.00618 1.26E-06 3.1878 0.529731 -1.06098 0.000473 -1.66618

Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 11.66E-06 1.57027 0.156468 -1.05853 0.938977 -1.00288 6.40E-07 -1.66697

RGD1566217similar to 40S ribosomal protein S160.852092 -1.02229 0.0024 -1.64797 0.76942 -1.03533 0.00207 -1.66898

Gng11 guanine nucleotide binding protein (G protein), gamma 110.0011297 3.94236 0.00742 2.68402 0.657402 -1.13631 0.102085 -1.66904

Col22a1 collagen, type XXII, alpha 10.0002093 -2.57906 3.72E-05 -3.35642 0.13085 -1.283 0.008536 -1.66971

Mab21l3 mab-21-like 3 (C. elegans)0.000425 3.15561 0.038398 1.63882 0.496477 1.15277 0.033093 -1.67035

Wipi1 WD repeat domain, phosphoinositide interacting 10.0492661 1.36776 0.023837 -1.45692 0.228361 1.19295 0.005286 -1.67041

Hspc159 galectin-related protein 0.002167 -1.76246 0.000403 -2.09783 0.029017 -1.40339 0.00384 -1.67043

Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 40.0389816 -1.44521 0.001577 -2.01248 0.257666 -1.19965 0.008882 -1.67053

RGD1560608similar to novel protein 8.59E-05 4.15994 0.001295 2.57899 0.861686 -1.03588 0.030643 -1.67088

Pik3ca phosphoinositide-3-kinase, catalytic, alpha polypeptide0.0225571 -1.55202 0.00078 -2.26541 0.411114 -1.14482 0.01099 -1.67104

Gja1 gap junction protein, alpha 10.0185606 1.48876 0.646555 1.06648 0.218782 -1.19759 0.005212 -1.67178

Cmah cytidine monophosphate-N-acetylneuraminic acid hydroxylase0.0001404 -6.22768 0.000516 -4.51565 0.014712 -2.30595 0.093104 -1.67203

Eps8 epidermal growth factor receptor pathway substrate 80.0289499 1.52513 0.065532 1.40326 0.026571 -1.5386 0.011943 -1.67223

Htr1d 5-hydroxytryptamine (serotonin) receptor 1D0.0166163 2.18752 0.786152 1.07549 0.472406 1.21604 0.082653 -1.67261

LOC100912115cutaneous T-cell lymphoma-associated antigen 5 homolog0.0062843 -1.50885 0.001049 -1.75124 0.011474 -1.44118 0.001771 -1.6727

Rasa1 RAS p21 protein activator (GTPase activating protein) 10.0032849 1.68586 0.677534 1.05603 0.720467 -1.04796 0.003572 -1.67297

Lztfl1 leucine zipper transcription factor-like 10.866284 1.02542 0.032975 -1.44979 0.436905 -1.12538 0.007346 -1.67303

Sdr16c5 short chain dehydrogenase/reductase family 16C, member 54.12E-09 8.42998 5.67E-09 7.74848 0.000648 -1.53781 0.000197 -1.67306

Map2 microtubule-associated protein 21.87E-05 2.21335 0.060534 1.2128 0.35779 1.09004 0.00039 -1.67424

Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble)0.0010185 1.68211 0.132715 1.18906 0.141698 -1.18372 0.001075 -1.67456


of 148Diabetes

Lancl1 LanC lantibiotic synthetase component C-like 1 (bacterial)1.65E-05 -3.37289 3.32E-06 -4.50953 0.127942 -1.25325 0.004658 -1.67559

Rc3h2 Ring finger and CCCH-type zinc finger domains 20.0701577 -1.18836 0.000276 -1.66133 0.058147 -1.20026 0.000242 -1.67796

Clec7a C-type lectin domain family 7, member a1.34E-05 8.63182 9.70E-05 5.14785 0.997355 -1.00078 0.053807 -1.6781

Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 20.0002942 3.7712 0.002402 2.59027 0.532416 -1.15294 0.044935 -1.67858

Olr1641 olfactory receptor 1641 0.203216 -1.36637 0.0164 -1.97725 0.528492 -1.15999 0.050517 -1.6786

Edn1 endothelin 1 0.898924 1.04323 0.046797 -2.13422 0.407339 1.32617 0.147151 -1.67888

Cd109 CD109 molecule 0.0003683 -2.19747 1.54E-06 -5.34564 0.024322 1.44852 0.00471 -1.67939

Igtp interferon gamma induced GTPase0.0542837 1.64434 0.044683 1.69023 0.038414 -1.72677 0.046664 -1.67989

Dusp14 dual specificity phosphatase 140.0022724 2.50226 0.846056 1.04264 0.125228 1.42835 0.037404 -1.6802

Dclk1 doublecortin-like kinase 10.0001609 -3.64207 3.16E-05 -5.08567 0.366609 -1.20445 0.028165 -1.68186

RGD1307934similar to DNA segment, Chr 19, ERATO Doi 386, expressed0.0186902 -1.48068 0.000257 -2.29036 0.547295 -1.08748 0.004567 -1.68215

Hmox1 heme oxygenase (decycling) 10.0017164 4.28282 0.016052 2.60614 0.94116 -1.02428 0.136949 -1.68327

Pde12 phosphodiesterase 12 4.49E-05 1.71493 0.003224 1.32401 0.004725 -1.29968 5.77E-05 -1.68342

Smchd1 structural maintenance of chromosomes flexible hinge domain containing 10.424 1.17163 0.381141 -1.19035 0.346132 -1.20708 0.024286 -1.68345

Tmem229b transmembrane protein 229B0.0079734 -1.90987 0.000602 -2.73629 0.405833 -1.17562 0.022239 -1.68431

Bre brain and reproductive organ-expressed protein0.0007141 -2.87952 0.000112 -4.0311 0.377922 -1.20404 0.030437 -1.68557

Csnk1g1 casein kinase 1, gamma 10.0001696 -1.91785 5.82E-06 -2.82334 0.20607 -1.14545 0.000733 -1.68626

Sorcs2 sortilin-related VPS10 domain containing receptor 20.0782969 1.5538 0.557905 -1.14284 0.820024 1.05269 0.043562 -1.68688

Dnah1 dynein, axonemal, heavy chain 10.0252678 1.35384 0.400938 -1.10286 0.299942 -1.13013 0.001464 -1.68739

LOC679692 Similar to lysophosphatidylglycerol acyltransferase 10.0009014 1.51999 0.219225 1.11506 0.03079 -1.23838 0.000207 -1.6881

DENND1B DENN/MADD domain containing 1B0.38384 -1.17079 0.080726 -1.40777 0.08265 -1.40411 0.015579 -1.68832

Vps37b vacuolar protein sorting 37 homolog B (S. cerevisiae)0.34578 -1.34581 0.061535 -1.90447 0.567709 -1.19323 0.115199 -1.68856

Creb1 cAMP responsive element binding protein 10.445103 -1.33294 0.163904 -1.73053 0.483569 -1.30064 0.181327 -1.68859

Abca1 ATP-binding cassette, subfamily A (ABC1), member 15.20E-05 -2.1222 0.000218 -1.84585 0.000126 -1.94186 0.000617 -1.68899

Smyd3 SET and MYND domain containing 30.964518 -1.00711 0.008577 -1.70552 0.986862 1.00263 0.00941 -1.68905

ADAM9 ADAM metallopeptidase domain 90.0032848 1.49905 0.052591 1.24945 0.008151 -1.4081 0.000683 -1.68939

Galk1 galactokinase 1 0.199285 1.14094 0.00501 -1.43475 0.743142 -1.03248 0.000529 -1.69014

Tra2a transformer 2 alpha homolog (Drosophila)0.219763 -1.2158 0.003124 -1.84406 0.48059 -1.11469 0.00721 -1.69069

Tspan5 tetraspanin 5 0.744993 1.06301 0.037489 -1.57138 0.946791 -1.01257 0.020009 -1.6914

RGD1309821Similar to KIAA1161 protein0.0448271 -1.36356 0.006988 -1.59966 0.023059 -1.44189 0.003802 -1.69154

Sh3bgrl SH3 domain binding glutamic acid-rich protein like0.243394 -1.15047 0.616072 -1.05978 0.000598 -1.83728 0.001488 -1.69244

Tm4sf1 transmembrane 4 L six family member 10.0182787 3.9998 0.114745 2.29358 0.951038 1.03016 0.29432 -1.69284

Crem cAMP responsive element modulator7.25E-05 1.77606 0.041999 1.20487 0.110067 -1.14857 0.000134 -1.69307

LOC683008 /// Smssimilar to spermine synthase /// spermine synthase0.0002643 2.02875 0.008464 1.4871 0.095468 -1.24137 0.001746 -1.69351

Elf5 E74-like factor 5 6.12E-07 2.08486 0.774149 -1.01556 0.002663 1.24972 7.66E-06 -1.69421

of 148 Diabetes

Sptlc1 serine palmitoyltransferase, long chain base subunit 10.385068 1.12194 0.251245 -1.16751 0.073779 -1.2937 0.002948 -1.69459

Rffl ring finger and FYVE like domain containing protein1.34E-07 2.31522 8.38E-06 1.63171 0.006447 -1.19561 4.72E-06 -1.69645

LOC685152 ATPase, class I, type 8B, member 20.352788 1.22097 0.677985 -1.0911 0.265676 -1.27403 0.030938 -1.69726

Map1b microtubule-associated protein 1B1.15E-07 7.99898 3.77E-06 3.75465 0.092006 1.25513 0.002123 -1.69737

Soat1 Sterol O-acyltransferase 10.0008214 3.65294 0.008662 2.36315 0.715677 -1.09857 0.066213 -1.69816

Tlr2 toll-like receptor 2 0.0060001 2.0604 0.003495 2.22036 0.014638 -1.83146 0.026328 -1.69952

Leprot leptin receptor overlapping transcript0.048346 -1.23497 0.000152 -1.83624 0.177885 -1.14332 0.000382 -1.69997

Mbnl2 muscleblind-like 2 0.0307459 -1.52218 0.012868 -1.66763 0.025503 -1.55193 0.010742 -1.70022

Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide0.0014744 -1.74172 2.30E-05 -2.78474 0.613539 -1.06351 0.001926 -1.70039

Rnd3 Rho family GTPase 3 0.711764 -1.11062 0.286435 -1.36743 0.270705 -1.3829 0.088021 -1.70268



Pkib protein kinase (cAMP-dependent, catalytic) inhibitor beta0.175876 2.0736 0.721079 1.1992 0.976338 1.01514 0.309779 -1.70335

Maob monoamine oxidase B 0.0004409 2.38014 0.342949 1.16492 0.265415 1.19881 0.007837 -1.70433

A2m alpha-2-macroglobulin 0.0005386 2.64736 0.083089 1.41487 0.611346 1.09712 0.015933 -1.70548

Krtdap keratinocyte differentiation associated protein7.26E-08 192.746 1.72E-07 111.133 0.95445 1.01683 0.09604 -1.70567

Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.0021963 -1.46164 0.00016 -1.76857 0.003884 -1.4102 0.000249 -1.70633

Timp1 TIMP metallopeptidase inhibitor 12.07E-08 18.3145 3.56E-08 15.08 0.033933 -1.40591 0.003886 -1.70747

Edem1 ER degradation enhancer, mannosidase alpha-like 10.010109 1.58845 0.233783 1.19484 0.10717 -1.28502 0.004711 -1.70835

ACADSB acyl-CoA dehydrogenase, short/branched chain2.01E-06 -3.48888 3.04E-07 -4.93714 0.104079 -1.20837 0.000826 -1.70998

Il1rn interleukin 1 receptor antagonist0.0336586 1.34606 0.021141 -1.39385 0.447838 1.09709 0.001706 -1.71016

MYO5A myosin VA (heavy chain 12, myoxin)1.65E-05 3.85421 0.000285 2.46532 0.559429 -1.09401 0.006613 -1.71035

Actr3 ARP3 actin-related protein 3 homolog (yeast)0.525869 -1.12847 0.54858 -1.12091 0.017553 -1.72189 0.01857 -1.71036

LOC687609 similar to ras homolog gene family, member f0.0003421 4.10717 0.004892 2.49348 0.877752 -1.03843 0.053676 -1.71047

Glul glutamate-ammonia ligase (glutamine synthetase)3.24E-05 -3.83259 4.72E-06 -5.71113 0.416125 -1.14816 0.010337 -1.71093

Cwf19l2 CWF19-like 2, cell cycle control (S. pombe)0.0090501 -1.76803 0.00028 -2.77526 0.618007 -1.0902 0.012114 -1.71128

Clip1 CAP-GLY domain containing linker protein 10.0766853 1.29277 0.092302 -1.27333 0.764453 -1.03997 0.002787 -1.71192

Yipf3 Yip1 domain family, member 30.615899 1.06522 0.122692 -1.23236 0.059416 -1.30449 0.00216 -1.71245

NUAK1 NUAK family, SNF1-like kinase, 10.198793 1.42944 0.456354 -1.22092 0.94406 1.01864 0.067739 -1.7133

Pcdhb12 protocadherin beta 12 0.003103 1.68961 0.465114 1.10116 0.403736 -1.11713 0.002655 -1.7141

Dpysl3 dihydropyrimidinase-like 31.80E-05 2.46293 0.000231 1.87552 0.028205 -1.30557 0.000642 -1.71447


Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform0.581577 -1.12875 0.149725 -1.39943 0.161765 -1.38418 0.033611 -1.71611

Sh3bp5 SH3-domain binding protein 5 (BTK-associated)0.0017107 3.32808 0.002359 3.12411 0.103976 -1.61184 0.071432 -1.71707

Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A41.02E-06 10.9669 8.67E-06 6.08292 0.794951 1.04986 0.017432 -1.71727

of 148Diabetes

Mga MAX gene associated 0.0803624 -1.39402 0.009364 -1.75829 0.099893 -1.36178 0.011549 -1.71761

Pex19 peroxisomal biogenesis factor 199.77E-06 -1.73389 1.47E-06 -2.02822 0.00013 -1.46909 1.10E-05 -1.71846

Aqp11 aquaporin 11 0.259683 1.29722 0.656263 -1.10422 0.420624 -1.19972 0.035576 -1.71849

Mex3d mex-3 homolog D (C. elegans)0.0005379 2.71855 0.011159 1.80551 0.483348 -1.14148 0.016862 -1.71872

Gfod2 glucose-fructose oxidoreductase domain containing 20.498736 1.11794 0.529929 -1.10883 0.070012 -1.38941 0.00863 -1.72232

Obfc2a oligonucleotide/oligosaccharide-binding fold containing 2A0.936405 1.01501 0.018633 -1.70317 0.985178 1.00347 0.01692 -1.72274

Tfpi tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.0018759 -4.72827 0.000385 -7.35874 0.772663 -1.10745 0.149567 -1.72355

LOC100362458rCG23949-like 0.665112 -1.05054 0.008302 -1.46524 0.089201 -1.23638 0.001099 -1.72444

Mycbp2 MYC binding protein 2 0.243024 1.24298 0.548297 -1.11422 0.239376 -1.24528 0.013428 -1.72465

Rufy3 RUN and FYVE domain containing 30.299972 1.16933 0.035143 -1.42964 0.830059 -1.0318 0.004795 -1.72488

Ucn2 urocortin 2 0.0006871 3.18058 0.017879 1.90116 0.891084 -1.03105 0.035805 -1.72492

Tmprss11d transmembrane protease, serine 11d1.32E-05 2.28072 0.0002 1.7566 0.011727 -1.32866 0.00025 -1.7251

Tsc22d3 TSC22 domain family, member 30.0010061 -3.32297 1.02E-05 -10.2338 0.041169 1.78518 0.0515 -1.72516

RGD1310552similar to hypothetical protein MGC389600.0025847 -2.62785 0.000489 -3.53911 0.300476 -1.28174 0.040902 -1.72621

Ggt1 gamma-glutamyltransferase 10.0197343 3.29211 0.002419 5.9738 0.023773 -3.13264 0.219775 -1.72637

Aldh3b2 aldehyde dehydrogenase 3 family, member B21.01E-06 4.7366 2.43E-05 2.76957 0.935591 -1.00984 0.00164 -1.72706

Slc31a2 solute carrier family 31 (copper transporters), member 20.327956 -1.14862 0.015049 -1.50687 0.07202 -1.31727 0.003377 -1.72812

Trio triple functional domain (PTPRF interacting)3.02E-05 2.60845 0.001381 1.72452 0.273477 -1.14328 0.001339 -1.72929

Cp ceruloplasmin 0.0003557 2.64249 0.010118 1.73311 0.465392 -1.13419 0.010321 -1.72931

Fam107b family with sequence similarity 107, member B0.964735 1.01174 0.0672 -1.71857 0.985408 1.00484 0.064459 -1.73037

Hook3 Hook homolog 3 (Drosophila)0.130178 -1.25195 0.010244 -1.56031 0.038991 -1.38884 0.003354 -1.73092

Tgfbi transforming growth factor, beta induced2.85E-06 12.7339 2.38E-05 6.78703 0.724593 1.08367 0.037332 -1.73136

Car2 carbonic anhydrase II 3.90E-07 64.0269 1.96E-06 29.1378 0.416816 1.26842 0.083225 -1.73238

Cldn1 claudin 1 2.14E-05 2.04217 0.023155 1.25434 0.464526 -1.0641 0.000139 -1.73245

Eea1 early endosome antigen 10.54135 1.05976 0.000305 -1.73465 0.535955 1.06061 0.000308 -1.73327

Aplp2 amyloid beta (A4) precursor-like protein 20.0343947 1.37658 0.278647 -1.15708 0.519604 -1.08823 0.002344 -1.73335

Tpr translocated promoter region0.424789 -1.10767 0.003099 -1.66146 0.267692 -1.15587 0.001935 -1.73375

Ebpl emopamil binding protein-like0.011282 1.83232 0.403463 -1.1772 0.271791 1.24394 0.017704 -1.734

Myo18a myosin XVIIIa 0.785951 -1.03369 0.000434 -1.96859 0.450061 1.09822 0.001611 -1.73411

Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A0.0472511 -1.71076 0.002837 -2.64327 0.627068 -1.12278 0.042973 -1.73478

Tpm1 tropomyosin 1, alpha 2.74E-05 5.30043 3.94E-05 4.8846 0.043 -1.5994 0.022473 -1.73556

LOC100361147rCG29620-like 1.79E-05 -4.98328 8.61E-06 -5.8862 0.06206 -1.46952 0.014552 -1.73578

6-Sep septin 6 2.97E-06 9.21924 2.47E-05 5.32281 0.991 -1.00225 0.021333 -1.73592

Cyba cytochrome b-245, alpha polypeptide0.0107526 2.26579 0.316503 1.3025 0.993492 1.00208 0.056319 -1.73595

RGD1565616RGD1565616 0.781579 -1.06011 0.648839 -1.10107 0.035449 -1.6724 0.026545 -1.73702

of 148 Diabetes

Gcnt1 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase1.10E-05 12.0463 0.000133 5.81867 0.517816 1.19041 0.063998 -1.73913

Sppl2a Signal peptide peptidase-like 2A0.107612 -1.16639 0.000279 -1.68378 0.057343 -1.20738 0.00018 -1.74294

Garnl4 GTPase activating Rap/RanGAP domain-like 40.0100875 2.26322 0.372746 1.25888 0.90398 1.03083 0.051999 -1.74403

Pgbd5 PiggyBac transposable element derived 50.0129649 -1.7111 4.78E-05 -3.79534 0.193554 1.27077 0.010868 -1.74545

Coq10b coenzyme Q10 homolog B (S. cerevisiae)0.0001484 1.85203 0.124887 1.17 0.314011 -1.10341 0.000293 -1.74664

RGD1310862similar to adult retina protein0.0060254 -1.73237 3.34E-05 -3.42892 0.426076 1.13254 0.005534 -1.74768

RGD1310862similar to adult retina protein0.0060254 -1.73237 3.34E-05 -3.42892 0.426076 1.13254 0.005534 -1.74768

Klhl13 kelch-like 13 (Drosophila)0.0018502 2.78559 0.093185 1.53433 0.872903 1.03781 0.037565 -1.74938

Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 44.63E-06 2.59987 0.030481 1.26012 0.098125 1.17935 0.000221 -1.74943

Dhx36 DEAH (Asp-Glu-Ala-His) box polypeptide 360.0841933 -1.2772 0.00059 -1.97323 0.345604 -1.13246 0.001984 -1.74962

Wwc2 WW and C2 domain containing 20.0210069 1.34082 0.011584 1.39577 0.00038 -1.8214 0.000599 -1.7497

Lnx1 ligand of numb-protein X 13.99E-06 -3.09776 5.35E-07 -4.34933 0.06326 -1.24654 0.000592 -1.75017

Slc46a3 solute carrier family 46, member 30.032191 -1.74208 0.000422 -3.44297 0.587862 1.1287 0.031021 -1.75101

Irak2 interleukin-1 receptor-associated kinase 20.851692 -1.046 0.244257 -1.3401 0.215601 -1.3678 0.042611 -1.75237

Hrasls5 HRAS-like suppressor family, member 50.0279495 1.43634 0.102787 -1.28258 0.723975 1.05068 0.003186 -1.75336

Ptpre protein tyrosine phosphatase, receptor type, E0.0352307 1.33949 0.184463 -1.18266 0.402519 -1.1075 0.001245 -1.75445

B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 52.06E-06 7.51639 2.80E-05 4.14604 0.850282 1.03314 0.009891 -1.75476

Rnf11 ring finger protein 11 0.0002416 -1.85233 3.16E-06 -3.07117 0.577495 -1.05879 0.000444 -1.75547

Tdrd3 tudor domain containing 30.0009905 -1.88208 2.08E-05 -3.03385 0.512707 -1.08958 0.00201 -1.75637

Tdrd3 tudor domain containing 30.0009905 -1.88208 2.08E-05 -3.03385 0.512707 -1.08958 0.00201 -1.75637

Klf6 Kruppel-like factor 6 0.0105701 1.98351 0.380358 -1.21122 0.168825 1.36645 0.025692 -1.75818


RGD1562378histone H4 variant H4-v.10.415473 1.12632 0.664852 1.06428 0.006339 -1.66185 0.003555 -1.75873

Arid5a AT rich interactive domain 5A (Mrf1 like)0.0039581 2.53591 0.154912 1.44127 0.999974 1.00001 0.041342 -1.75948

Manba mannosidase, beta A, lysosomal0.001718 -2.21295 0.000106 -3.36947 0.4237 -1.1561 0.01108 -1.76029

Dsg1b desmoglein 1 beta 5.83E-05 1.66909 0.034002 1.18558 0.01005 -1.25043 2.86E-05 -1.76039

C1ql3 complement component 1, q subcomponent-like 36.78E-07 -3.14842 0.075497 1.18285 1.42E-08 -6.55984 0.000127 -1.76145

Sertad4 SERTA domain containing 40.0003239 2.36089 0.19942 1.2218 0.54109 1.09572 0.004169 -1.7635

Serpinb3 serine protease inhibitor B36.94E-06 6.70433 0.000149 3.47347 0.639051 1.09447 0.015505 -1.76355

Sipa1l2 signal-induced proliferation-associated 1 like 20.0342214 1.25471 0.004649 -1.41299 0.956243 1.00505 0.000214 -1.76398

Mdm2 Mdm2 p53 binding protein homolog (mouse)0.0186342 1.4904 0.793803 -1.03733 0.359229 -1.14099 0.003056 -1.76401

LOC684173 similar to TNF receptor-associated factor 50.0002792 -2.3437 7.23E-05 -2.81626 0.024497 -1.46809 0.003499 -1.7641

Crem cAMP responsive element modulator0.300004 1.30598 0.735101 -1.08807 0.394961 -1.24178 0.046145 -1.76457

Dirc2 disrupted in renal carcinoma 2 (human)0.0540807 -1.54989 0.001855 -2.42397 0.544585 -1.13078 0.018854 -1.76849

Nsbp1 nucleosomal binding protein 12.89E-07 -3.95087 1.08E-07 -4.75588 0.00239 -1.47037 0.000195 -1.76996

of 148Diabetes

Herc4 hect domain and RLD 4 0.456991 1.11179 0.007719 -1.61412 0.926372 1.01301 0.002926 -1.7715

Nucb2 nucleobindin 2 3.72E-05 2.35885 0.00015 2.02358 0.004008 -1.51979 0.000608 -1.77159

Cldn1 claudin 1 8.63E-08 3.10199 4.20E-06 1.98192 0.081597 -1.13206 1.60E-05 -1.77184

Errfi1 ERBB receptor feedback inhibitor 10.161796 1.32641 0.098108 -1.40926 0.779158 1.05459 0.014158 -1.7725

Cd48 Cd48 molecule 0.0112497 2.97786 0.132964 1.74551 0.911234 -1.03907 0.12396 -1.77266

Mxd4 Max dimerization protein 40.3862 1.13621 0.159077 -1.24154 0.138767 -1.25744 0.003375 -1.7738

Kif26b kinesin family member 26B0.0094516 2.57434 0.062479 1.82718 0.432441 -1.25901 0.073722 -1.77383

Lpgat1 lysophosphatidylglycerol acyltransferase 11.56E-05 2.51151 0.000621 1.72118 0.084673 -1.2173 0.00043 -1.77626

Pgm2l1 phosphoglucomutase 2-like 10.0003315 -3.28038 6.13E-05 -4.55466 0.249666 -1.27976 0.020115 -1.77689

Ube2g2 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)0.0262231 -1.52036 0.001186 -2.12828 0.159519 -1.26975 0.005744 -1.77747

Col5a1 Collagen, type V, alpha 10.0001116 4.4188 0.006699 2.15804 0.526432 1.15072 0.026311 -1.77941

Gstm1 glutathione S-transferase mu 10.0284946 3.9631 0.060917 3.08109 0.547158 -1.38339 0.296765 -1.77941

Il8rb interleukin 8 receptor, beta2.66E-05 4.4242 0.000867 2.44828 0.936228 1.01444 0.010457 -1.78134

Wdr44 WD repeat domain 44 0.169721 1.15922 0.033691 -1.28474 0.103015 -1.19741 0.000358 -1.7833

Elmod1 ELMO/CED-12 domain containing 10.0009674 -4.77955 9.72E-05 -9.08606 0.841933 1.06565 0.09763 -1.78391

Ttll7 tubulin tyrosine ligase-like family, member 72.13E-07 2.33089 1.24E-05 1.64357 0.00232 -1.25795 3.95E-06 -1.784

Cxcl2 chemokine (C-X-C motif) ligand 20.0001591 11.9838 0.001198 6.20958 0.839508 1.08114 0.158792 -1.78506

Tbl1x transducin (beta)-like 1 X-linked0.037047 -1.44008 0.000911 -2.1105 0.213504 -1.21811 0.00412 -1.7852

Abcb1a /// Abcb1bATP-binding cassette, sub-family B (MDR/TAP), member 1A /// ATP-binding cassette, sub-f0.473004 -1.16674 0.029474 -1.71895 0.375456 -1.21191 0.022128 -1.78549

Rcan1 regulator of calcineurin 10.864524 1.02368 0.013623 -1.51932 0.327397 -1.14861 0.002387 -1.78643

Hey2 hairy/enhancer-of-split related with YRPW motif 20.269896 -1.62517 0.258151 -1.64664 0.203353 -1.76393 0.194126 -1.78723

Rnasel Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)0.0349087 -1.47285 0.003817 -1.84851 0.049114 -1.42445 0.005195 -1.78776

Ccrn4l CCR4 carbon catabolite repression 4-like (S. cerevisiae)0.209056 -1.20287 0.000877 -2.00562 0.614523 -1.07341 0.002597 -1.78976

Pcdh19 protocadherin 19 3.62E-06 3.31989 2.79E-05 2.4894 0.025206 -1.34211 0.000621 -1.78985

Uqcrc2 ubiquinol cytochrome c reductase core protein 20.914224 -1.02638 0.132334 -1.48073 0.383918 -1.24083 0.037779 -1.79011

Ghr growth hormone receptor0.0137502 3.37696 0.896714 1.05326 0.170867 1.79071 0.170954 -1.79047

Il24 interleukin 24 5.77E-07 78.8844 2.37E-06 37.8382 0.633715 1.16409 0.094039 -1.79091

REPS2 RALBP1 associated Eps domain containing 20.0016847 -2.08194 5.11E-05 -3.45269 0.636646 -1.08083 0.006166 -1.79245

Rdh12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)0.0010029 3.02456 0.102176 1.49983 0.606482 1.12496 0.028922 -1.79261

LOC100361304hypothetical LOC1003613042.03E-07 11.8661 7.16E-07 8.18327 0.1987 -1.23707 0.004885 -1.79381

Sprr3 small proline-rich protein 30.0004463 12.0491 0.003141 6.13536 0.840834 1.09455 0.21632 -1.79423

Hspa1a /// Hspa1bheat shock 70kD protein 1A /// heat shock 70kD protein 1B (mapped)0.226484 -1.14043 9.64E-05 -2.05005 0.988631 1.00148 0.00039 -1.79496

Clu clusterin 2.13E-07 16.6351 2.26E-06 7.9282 0.396727 1.16826 0.009766 -1.79601

Samd12 sterile alpha motif domain containing 120.0055543 -1.66494 0.002813 -1.77875 0.004988 -1.68208 0.00254 -1.79707

Flvcr2 feline leukemia virus subgroup C cellular receptor family, member 22.32E-05 8.97678 0.000145 5.45411 0.734308 -1.09239 0.047913 -1.79794

of 148 Diabetes

Thrsp thyroid hormone responsive0.0026964 -2.07763 0.001494 -2.24242 0.017431 -1.66612 0.008917 -1.79828

LOC100361349 /// LOC100361455hypothetical protein LOC100361349 /// hypothetical protein LOC1003614550.0002393 8.37043 0.001246 5.19538 0.751422 -1.11743 0.120724 -1.80032

Bnip3 BCL2/adenovirus E1B interacting protein 30.00015 3.2749 0.004053 2.02008 0.563492 -1.11228 0.010255 -1.80319

RGD1565095Similar to hypothetical protein MGC521100.207129 -1.67163 0.026846 -2.75314 0.813989 -1.0953 0.153662 -1.80393

Pmm2 phosphomannomutase 20.311681 1.1977 0.610753 -1.09251 0.090698 -1.37887 0.007704 -1.80426

Faim3 Fas apoptotic inhibitory molecule 30.0002573 3.49508 0.000877 2.82251 0.097769 -1.45909 0.018868 -1.80678

Otud1 OTU domain containing 10.957281 1.00991 0.007044 -1.89849 0.748238 1.06106 0.010589 -1.80697

Hspa4l heat shock protein 4 like6.13E-06 5.31587 0.000131 2.99029 0.91679 -1.0174 0.006003 -1.80864

Hspb1 heat shock protein 1 0.119683 1.16062 0.000634 -1.58891 0.845965 1.01731 0.000118 -1.81274

Aspn asporin 0.0162869 2.55448 0.244074 1.47561 0.885167 -1.04722 0.09075 -1.81287

Prpf40a PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)0.891271 1.01172 0.000707 -1.55217 0.120129 -1.15448 9.20E-05 -1.81295

Gpr177 G protein-coupled receptor 1770.0028044 -1.66878 6.86E-05 -2.47255 0.131238 -1.22462 0.001131 -1.81446


Acvr1 activin A receptor, type I0.0007742 2.46031 0.016167 1.68306 0.24136 -1.24234 0.008329 -1.81606


Il6 interleukin 6 0.0846315 2.0065 0.873051 1.06012 0.91342 1.04051 0.129379 -1.81901

Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 20.0006445 2.30631 0.199643 1.24144 0.904748 1.01929 0.004672 -1.82262

Sort1 sortilin 1 0.0003279 -2.20369 1.83E-05 -3.28483 0.164443 -1.22379 0.001861 -1.82419

Armcx2 armadillo repeat containing, X-linked 21.05E-08 7.20529 8.84E-08 4.50945 0.149421 -1.14176 8.96E-05 -1.82433

Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 30.136769 -1.34943 0.062174 -1.48077 0.022688 -1.66529 0.010432 -1.82737

Lphn2 latrophilin 2 0.147277 1.25785 0.029064 -1.46154 0.97271 1.00506 0.002902 -1.82914


Reep1 receptor accessory protein 10.0091048 2.03257 0.912375 -1.02384 0.557473 1.13541 0.019284 -1.83285

Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 20.124751 -1.45003 0.002508 -2.5565 0.861426 -1.03984 0.02331 -1.8333


Pkp2 Plakophilin 2 0.184441 1.25001 0.083908 1.35416 0.002075 -1.98816 0.004224 -1.83525

Cflar CASP8 and FADD-like apoptosis regulator0.448639 -1.12257 0.007473 -1.67478 0.190462 -1.23072 0.00305 -1.83614

Dab2 disabled homolog 2 (Drosophila)0.0001081 3.50393 0.018091 1.69459 0.523757 1.12604 0.009184 -1.83626

Tdrd1 tudor domain containing 10.173856 1.42243 0.749292 1.08122 0.19547 -1.39578 0.032895 -1.83627

Sparc secreted protein, acidic, cysteine-rich (osteonectin)0.260966 1.22376 0.103964 -1.35826 0.565815 -1.10515 0.006563 -1.83696

Bhlhe40 Basic helix-loop-helix family, member e400.866746 -1.04084 0.19861 -1.38237 0.197494 -1.38361 0.029997 -1.83761

Tgfb3 transforming growth factor, beta 30.0017403 5.91088 0.020124 3.05148 0.896032 1.0534 0.152922 -1.83885

Tspyl4 TSPY-like 4 0.0002628 -1.61166 2.00E-06 -2.54463 0.080071 -1.16711 4.67E-05 -1.84273

Trib1 tribbles homolog 1 (Drosophila)0.187368 1.13347 0.001278 -1.52366 0.467861 -1.06847 0.000107 -1.84527

Sf3b1 Splicing factor 3b, subunit 10.0113486 -1.5965 6.89E-05 -2.9259 0.962902 -1.00689 0.002677 -1.84532

of 148Diabetes

Lpgat1 lysophosphatidylglycerol acyltransferase 18.08E-06 2.65065 0.000711 1.67394 0.152515 -1.16544 0.000226 -1.84546

Uap1 UDP-N-acteylglucosamine pyrophosphorylase 15.03E-07 2.52352 0.000244 1.4911 0.195873 -1.09431 1.11E-05 -1.85199

Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 72.80E-06 7.20783 0.000107 3.33037 0.392121 1.16676 0.006747 -1.85494

Rab5a RAB5A, member RAS oncogene family0.172879 -1.22167 0.00248 -1.78707 0.113694 -1.26816 0.001713 -1.85508

Lrrc17 leucine rich repeat containing 170.0139121 2.2905 0.856254 -1.0507 0.354079 1.297 0.047543 -1.85553

Tpd52l1 tumor protein D52-like 11.22E-05 9.12092 3.04E-05 7.04167 0.159916 -1.43262 0.028619 -1.85564


Hspa2 heat shock protein alpha 20.0004271 4.0559 0.030681 1.89156 0.572165 1.15409 0.034409 -1.85792

Tm9sf3 transmembrane 9 superfamily member 30.424171 -1.09948 0.042214 -1.31247 0.004368 -1.55641 0.000573 -1.85792

As3mt arsenic (+3 oxidation state) methyltransferase0.974408 -1.0027 0.673608 1.03622 4.06E-05 -1.93046 6.24E-05 -1.85797

Stfa2l3 stefin A2-like 3 0.0015145 6.05307 0.082855 2.13169 0.299423 1.52782 0.143333 -1.85858

Prr5l proline rich 5 like 0.0001392 4.14082 0.014087 1.92369 0.503936 1.15768 0.018034 -1.85936

Sez6 seizure related 6 homolog (mouse)0.0655012 -1.33556 0.000437 -2.17658 0.354268 -1.1427 0.001794 -1.86227

SLC9A9 solute carrier family 9 (sodium/hydrogen exchanger), member 90.199445 1.30676 0.807624 -1.04932 0.146275 -1.36039 0.011537 -1.86538

Igsf11 immunoglobulin superfamily, member 110.0089845 -5.02262 0.046299 -3.03124 0.0434 -3.09094 0.22202 -1.86543

Nek7 NIMA (never in mitosis gene a)-related kinase 70.0006879 -1.84109 7.43E-05 -2.33411 0.009117 -1.47713 0.000576 -1.87268

Tspan2 tetraspanin 2 7.56E-05 4.17271 0.001762 2.42668 0.667047 -1.08993 0.011574 -1.87415

Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi0.0023645 4.16464 0.021881 2.52291 0.706302 -1.13583 0.090046 -1.87494

Procr protein C receptor, endothelial2.32E-06 10.7554 1.23E-05 6.70655 0.457052 -1.16921 0.013754 -1.87508

Per2 period homolog 2 (Drosophila)0.0001017 -2.63058 2.05E-06 -5.17517 0.747474 1.04643 0.001675 -1.88002

Kif3a kinesin family member 3a0.0020229 2.04269 0.27339 1.20562 0.531109 -1.10969 0.004115 -1.88016

Hsph1 heat shock 105kDa/110kDa protein 15.24E-05 4.49676 0.00072 2.78275 0.45447 -1.16361 0.011259 -1.88032

MFAP3L microfibrillar-associated protein 3-like1.79E-05 -3.35269 2.28E-06 -4.91493 0.099643 -1.28291 0.001501 -1.88069

Pak2 P21 protein (Cdc42/Rac)-activated kinase 20.146414 -1.308 0.019532 -1.62597 0.037944 -1.51357 0.00534 -1.88151

Lnx1 ligand of numb-protein X 16.14E-05 -3.57759 5.76E-06 -5.81153 0.395309 -1.16195 0.005227 -1.8875

Ptger3 Prostaglandin E receptor 30.0098374 1.4645 0.63051 -1.05831 0.120052 -1.21797 0.000506 -1.88773

Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha9.40E-05 -2.44747 2.56E-06 -4.31079 0.586666 -1.07313 0.00092 -1.89013

Igfbp6 insulin-like growth factor binding protein 60.0001451 -1.56845 3.52E-05 -1.73252 4.15E-05 -1.7112 1.20E-05 -1.89019

Fam176b family with sequence similarity 176, member B4.83E-06 10.7925 3.66E-05 6.10299 0.769583 -1.06915 0.020299 -1.89069

Irs2 insulin receptor substrate 20.543332 1.05411 1.00E-05 -2.25159 0.025746 1.25465 5.86E-05 -1.89169

Slco3a1 Solute carrier organic anion transporter family, member 3a13.11E-06 -3.07599 2.19E-07 -4.88283 0.109732 -1.19347 0.000188 -1.89452

TMTC4 transmembrane and tetratricopeptide repeat containing 40.0045469 1.70763 0.245123 1.18782 0.078487 -1.31877 0.00162 -1.89588

Cd200 Cd200 molecule 0.0045976 2.12747 0.402898 1.18687 0.773979 -1.05932 0.010767 -1.89883

Hook3 hook homolog 3 (Drosophila)0.647086 -1.0677 0.000807 -2.05098 0.935497 1.01157 0.001632 -1.89897

Ereg epiregulin 0.0383121 2.05837 0.356847 1.32976 0.500995 -1.22803 0.058663 -1.90091

of 148 Diabetes


Cfi complement factor I 7.72E-06 7.53053 4.80E-05 4.82652 0.348919 -1.21937 0.012123 -1.90251

Diaph1 diaphanous homolog 1 (Drosophila)0.0339366 -1.43587 0.00018 -2.52521 0.593683 -1.08186 0.001894 -1.90263


Aldh1l1 aldehyde dehydrogenase 1 family, member L10.0007513 1.64519 0.937661 -1.00765 0.179719 -1.14886 0.000134 -1.90455


Fam167a family with sequence similarity 167, member A1.22E-06 72.3803 9.44E-06 26.2765 0.303256 1.44022 0.086233 -1.9126

RGD1309847similar to peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor; pept0.207135 -1.78007 0.009637 -4.13785 0.655238 1.21507 0.161143 -1.91309

Fam171b family with sequence similarity 171, member B0.002476 2.87913 0.195451 1.4108 0.798436 1.06644 0.028627 -1.91364

Col5a2 collagen, type V, alpha 20.0232164 2.96398 0.429795 1.38089 0.775014 1.1216 0.133008 -1.91372


Camta1 similar to KIAA0833 protein8.72E-06 -2.16174 1.47E-07 -3.7218 0.201205 -1.11378 3.03E-05 -1.91756

Jun Jun oncogene 0.0076437 2.90819 0.253535 1.44952 0.884908 1.04612 0.062972 -1.91785

TCF7 transcription factor 7 (T-cell specific, HMG-box)9.68E-05 4.33162 0.01187 1.9427 0.485792 1.16155 0.012959 -1.91958

Atp7a ATPase, Cu++ transporting, alpha polypeptide0.175856 1.50769 0.164217 1.52716 0.042829 -1.94453 0.046045 -1.91974

Adrb2 adrenergic, beta-2-, receptor, surface0.0014735 -2.02606 1.77E-05 -3.85741 0.956524 -1.00842 0.002367 -1.91994

Il7 interleukin 7 1.20E-06 2.88678 4.86E-05 1.90672 0.019149 -1.27061 4.41E-05 -1.9237

Wasl Wiskott-Aldrich syndrome-like0.347931 1.17432 0.006564 -1.79868 0.578735 1.09775 0.003628 -1.92415

Cxcr4 chemokine (C-X-C motif) receptor 40.0048288 4.36656 0.065942 2.2556 0.991081 1.00442 0.124307 -1.92736

Clip1 CAP-GLY domain containing linker protein 10.000588 1.71864 0.477208 -1.07648 0.686677 -1.04222 0.000162 -1.92818

Abca1 ATP-binding cassette, subfamily A (ABC1), member 10.0023307 -1.64393 0.000116 -2.20286 0.012277 -1.44012 0.000405 -1.92976

LOC688090 /// RT1-Bbsimilar to RT1 class II histocompatibility antigen, B-1 beta chain precursor (RT1.B-bet4.72E-05 5.41491 0.001187 2.84883 0.941812 -1.01621 0.015025 -1.93156

Mgea5 meningioma expressed antigen 5 (hyaluronidase)0.0053818 -1.61257 0.000191 -2.2697 0.036159 -1.37396 0.000804 -1.93385

Ptpn4 protein tyrosine phosphatase, non-receptor type 40.0315577 -1.38316 0.001798 -1.77062 0.010708 -1.51087 0.000737 -1.9341

Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 10.0084272 1.86104 0.916774 1.01948 0.749623 -1.06089 0.006097 -1.93663

Rab7b Rab7b, member RAS oncogene family0.66172 1.03856 0.000523 -1.59146 0.093344 -1.17188 4.62E-05 -1.93691

Hsdl2 hydroxysteroid dehydrogenase like 20.0047302 -2.2351 0.000412 -3.32688 0.239757 -1.30192 0.012905 -1.93787

Gabarapl1 GABA(A) receptor-associated protein like 10.0098234 -1.63564 0.000156 -2.65324 0.257961 -1.19477 0.001928 -1.93809

Usp2 ubiquitin specific peptidase 29.86E-05 2.41316 0.067651 1.29798 0.731761 -1.04481 0.000664 -1.94249

PTPRE protein tyrosine phosphatase, receptor type, E0.403656 -1.09783 0.00483 -1.50423 0.010812 -1.41855 0.000238 -1.94367

Pgcp plasma glutamate carboxypeptidase0.0058426 1.84388 0.937784 1.01332 0.695607 -1.06894 0.003692 -1.94508

Trex2 three prime repair exonuclease 20.087058 1.34617 0.005393 -1.77942 0.210347 1.23079 0.00239 -1.94622

Lef1 lymphoid enhancer binding factor 10.0027654 3.30282 0.103327 1.67479 0.964048 1.01313 0.044951 -1.94652

Bet1l blocked early in transport 1 homolog (S. cerevisiae) like0.143038 -1.35878 0.009108 -1.90671 0.121202 -1.38721 0.007752 -1.94661

CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)4.68E-06 2.1207 8.35E-05 1.66066 0.000297 -1.52492 1.15E-05 -1.94735

of 148Diabetes

Echdc2 enoyl Coenzyme A hydratase domain containing 24.30E-05 4.04107 7.96E-05 3.60075 0.012951 -1.74093 0.004915 -1.95382

Fhl2 four and a half LIM domains 23.66E-06 39.2567 1.32E-05 22.0322 0.782022 -1.09847 0.074953 -1.95723

Herc3 hect domain and RLD 3 4.08E-07 2.6581 0.001185 1.38005 0.809111 -1.01653 7.15E-06 -1.95794

Nek6 NIMA (never in mitosis gene a)-related kinase 69.77E-09 10.6458 1.50E-07 5.31531 0.825667 1.02271 0.000136 -1.95838

Nt5dc1 5'-nucleotidase domain containing 10.0054588 -2.52357 0.0016 -3.14757 0.102327 -1.57271 0.025266 -1.9616

RT1-Ba RT1 class II, locus Ba 4.12E-05 5.14776 0.00171 2.55677 0.90209 1.02614 0.010583 -1.9621

Rasa2 RAS p21 protein activator 20.0644519 -1.26639 9.68E-05 -2.19958 0.299157 -1.13014 0.000283 -1.96293

Cldn1 claudin 1 7.09E-05 2.01383 0.028888 1.28263 0.043153 -1.25204 9.08E-05 -1.9658

Krtdap keratinocyte differentiation associated protein2.13E-07 66.4323 3.91E-07 48.4981 0.20064 -1.43559 0.031216 -1.96646

Cd68 Cd68 molecule 0.059168 -1.5951 0.077611 -1.53708 0.009898 -2.04261 0.012845 -1.96832

Lix1l Lix1 homolog (mouse)-like8.13E-05 5.06941 0.005502 2.30161 0.625599 1.11887 0.015601 -1.96854

COL6A3 collagen, type VI, alpha 30.0207674 1.86341 0.979472 -1.00577 0.823819 -1.05112 0.014046 -1.96997

Gpr68 G protein-coupled receptor 680.0005349 3.87409 0.068422 1.66984 0.522526 1.1769 0.023699 -1.9713

Rtp4 receptor (chemosensory) transporter protein 40.868124 1.11691 0.270739 2.14456 0.072824 -3.78663 0.323065 -1.97212

Mex3b mex3 homolog B (C. elegans)0.0008923 3.1236 0.2199 1.34352 0.481293 1.17805 0.015488 -1.97354

Sult1d1 sulfotransferase family 1D, member 10.605008 -1.13078 0.007528 -2.24821 0.975584 1.00724 0.017643 -1.97391

Cav1 caveolin 1, caveolae protein0.0210633 1.75238 0.392027 1.19398 0.168534 -1.34534 0.008421 -1.97452

Trpv1 transient receptor potential cation channel, subfamily V, member 17.19E-06 3.54268 0.001947 1.74956 0.865654 1.02185 0.000555 -1.9816

Chmp1b Chromatin modifying protein 1B0.732959 -1.06763 0.011994 -1.82008 0.439958 -1.16242 0.006106 -1.98167

Slc41a2 solute carrier family 41, member 20.0063363 1.59058 0.666373 -1.05827 0.22556 -1.18079 0.000625 -1.98758

Il13ra1 interleukin 13 receptor, alpha 15.28E-06 4.45927 2.92E-05 3.27772 0.026589 -1.46309 0.001186 -1.99051

Zfand2a zinc finger, AN1-type domain 2A0.001403 3.95141 0.057351 1.89371 0.880543 1.04568 0.043185 -1.99545

Elk3 ELK3, member of ETS oncogene family9.93E-05 2.2058 0.206946 1.16464 0.641235 -1.05521 0.000249 -1.99854

FAM49A family with sequence similarity 49, member A0.0042225 2.6539 0.070476 1.6738 0.37472 -1.2613 0.022967 -1.99985

Lamc2 laminin, gamma 2 4.36E-06 28.9135 1.77E-05 16.2433 0.707852 -1.12702 0.05361 -2.00612

Map3k8 mitogen-activated protein kinase kinase kinase 80.0019062 -1.63635 1.82E-05 -2.66184 0.088156 -1.23456 0.000204 -2.00826

Bcat1 branched chain aminotransferase 1, cytosolic3.75E-08 38.193 2.55E-07 17.2997 0.615607 1.09871 0.004728 -2.00938

Ube2h ubiquitin-conjugating enzyme E2H0.0926894 -1.43415 0.00194 -2.35032 0.310183 -1.2271 0.006055 -2.011

Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 14.95E-06 2.5148 0.011784 1.32113 0.527039 -1.05838 3.78E-05 -2.01466

Bmp2 bone morphogenetic protein 20.88353 -1.02355 4.88E-05 -3.36115 0.013266 1.6279 0.001851 -2.01721

Ch25h cholesterol 25-hydroxylase0.0328551 3.08327 0.410422 1.46188 0.921876 1.04524 0.147027 -2.01781

Nt5e 5' nucleotidase, ecto 1.34E-06 10.3103 3.05E-05 4.65278 0.627738 1.0966 0.004905 -2.02074

Fos FBJ osteosarcoma oncogene0.245071 2.282 0.860975 1.12631 0.99697 1.00258 0.315955 -2.02087

Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.917884 -1.02892 0.136445 -1.55833 0.311048 -1.33615 0.030163 -2.02363

Klf2 Kruppel-like factor 2 (lung)0.0001203 2.46246 0.364963 1.13293 0.605312 1.0724 0.000619 -2.02679

of 148 Diabetes

Rnf128 ring finger protein 128 0.0024278 2.83228 0.055932 1.70582 0.428126 -1.22081 0.018262 -2.02699

Gjb5 gap junction protein, beta 50.101804 1.36244 0.071799 -1.41495 0.767655 -1.05249 0.002887 -2.02898


Csnk1e casein kinase 1, epsilon 0.5398 -1.14247 0.033617 -1.70323 0.17428 -1.36356 0.009207 -2.03285


Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 14.10E-06 2.2596 0.176899 1.11581 0.937525 -1.006 1.14E-05 -2.03724

Wrb tryptophan rich basic protein0.374149 -1.25615 0.282677 -1.3219 0.02597 -1.93621 0.018783 -2.03755

Gadd45a growth arrest and DNA-damage-inducible, alpha0.740965 1.11077 0.042595 -2.09445 0.678802 1.14095 0.048817 -2.03904

LOC100363005rCG32052-like 0.0018069 2.16291 0.183034 1.27844 0.297295 -1.20667 0.002857 -2.04148

Jun Jun oncogene 0.0048237 3.50617 0.061184 2.02954 0.616059 -1.18486 0.058732 -2.04693

Gclc glutamate-cysteine ligase, catalytic subunit0.260758 -1.17803 0.676953 -1.06027 0.000299 -2.27493 0.000735 -2.04752

Golga4 golgi autoantigen, golgin subfamily a, 40.0060842 -1.69204 0.000553 -2.19756 0.012088 -1.58324 0.000971 -2.05626

Col5a3 collagen, type V, alpha 30.0029257 3.98857 0.09361 1.86648 0.912336 1.03797 0.058864 -2.05877

Tcrb T-cell receptor beta chain0.530861 -1.09622 0.165432 -1.23874 0.002671 -1.82393 0.000868 -2.06107

Wfdc5 WAP four-disulfide core domain 50.0126643 2.98978 0.000615 6.44904 0.002422 -4.4483 0.067558 -2.06223

Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.0062095 2.44807 0.429755 1.22417 0.898044 -1.03269 0.017554 -2.06516

Mlf1 myeloid leukemia factor 19.47E-06 12.3967 7.15E-05 6.73556 0.662711 -1.12263 0.021786 -2.06618

Sqrdl sulfide quinone reductase-like (yeast)0.106354 1.87326 0.24849 1.53633 0.163971 -1.69666 0.068181 -2.06875

Hspa2 heat shock protein alpha 20.0021386 6.55164 0.026157 3.1577 0.996927 1.00168 0.122997 -2.07133

Umps uridine monophosphate synthetase0.0189579 2.23193 0.237418 1.41872 0.341191 -1.31937 0.028524 -2.07564

Lef1 Lymphoid enhancer binding factor 10.0003543 7.41825 0.008269 3.25338 0.790183 1.09764 0.062867 -2.07734

Ptrh1 /// Tor2apeptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) /// torsin family 2, member A0.0256318 1.54909 0.630416 -1.08332 0.217958 -1.23855 0.001819 -2.07847

Ptgs2 prostaglandin-endoperoxide synthase 20.09713 2.43547 0.256599 1.78409 0.400838 -1.52261 0.161157 -2.07851

RNF128 ring finger protein 128 0.0011998 3.40104 0.007984 2.40386 0.160786 -1.47171 0.018896 -2.08221

Fhl2 four and a half LIM domains 24.01E-07 85.2904 1.50E-06 42.3245 0.914378 -1.03361 0.039136 -2.08288

N4bp1 Nedd4 binding protein 10.224291 -1.21837 0.000182 -2.66232 0.76825 1.04678 0.001182 -2.0875

Basp1 /// LOC100910172brain abundant, membrane attached signal protein 1 /// brain acid soluble protei0.0006317 5.47924 0.005752 3.22913 0.524126 -1.23253 0.046646 -2.09138

Cdkn1a cyclin-dependent kinase inhibitor 1A0.127415 -1.30175 0.003292 -1.89766 0.047405 -1.43743 0.001407 -2.09546

Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 10.001725 2.79662 0.752731 1.0754 0.367364 1.23735 0.010354 -2.10172

Accn1 amiloride-sensitive cation channel 1, neuronal7.96E-06 2.5215 5.36E-05 2.03975 0.000406 -1.70171 3.95E-05 -2.10363

Cdh2 cadherin 2 0.0157674 2.26441 0.554296 1.17969 0.739336 -1.09664 0.023939 -2.10499

Cxcr4 chemokine (C-X-C motif) receptor 40.0024392 5.62973 0.030871 2.82509 0.892672 -1.05686 0.097544 -2.10608

Manea mannosidase, endo-alpha0.924421 -1.01378 0.016298 -1.5274 0.043158 -1.39862 0.0007 -2.10721

Nedd4 neural precursor cell expressed, developmentally down-regulated 40.240282 1.28295 0.341285 -1.21985 0.165891 -1.34911 0.005201 -2.11138

Serpinb7 serine (or cysteine) peptidase inhibitor, clade B, member 70.0551098 1.75955 0.619442 1.13893 0.249307 -1.36734 0.017887 -2.11243

of 148Diabetes

Abhd3 abhydrolase domain containing 30.640151 1.09449 0.041386 -1.5701 0.295783 -1.2311 0.00378 -2.11561

RGD1311224similar to fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6-desaturase)-like 7.46E-06 8.46071 1.15E-05 7.49469 0.017255 -1.8742 0.007287 -2.11578

Ass1 argininosuccinate synthetase 10.0001836 -3.89424 0.000147 -4.06962 0.009573 -2.02481 0.007021 -2.116

Cald1 caldesmon 1 0.0021239 3.12687 0.228999 1.39552 0.833267 1.05723 0.01884 -2.11936

Mamdc2 MAM domain containing 20.0013961 3.31962 0.176845 1.45067 0.772267 1.0781 0.017166 -2.12256

Snap29 synaptosomal-associated protein 290.304874 1.20319 0.383346 -1.16839 0.040135 -1.51114 0.002096 -2.12433

LOC100360933cDNA sequence BC048679-like0.0004402 3.02436 0.103262 1.42656 0.991715 -1.00207 0.004547 -2.12443


rnf141 ring finger protein 141 0.568053 1.11342 0.817584 -1.04395 0.009799 -1.83671 0.002985 -2.13492

MYO10 myosin X 0.0592201 1.5944 0.953675 -1.0128 0.224377 -1.32251 0.007248 -2.13561

Jun Jun oncogene 0.0284831 2.43671 0.578448 1.21334 0.856424 -1.06438 0.052479 -2.13756

Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A0.139115 -1.4664 0.00658 -2.33634 0.237534 -1.34655 0.01127 -2.14539

Bphl biphenyl hydrolase-like (serine hydrolase)0.184403 -1.85719 0.052925 -2.6307 0.356692 -1.51714 0.110386 -2.14902

Fam103a1 family with sequence similarity 103, member A10.572302 -1.29217 0.249724 -1.71665 0.300548 -1.61914 0.116588 -2.15104

Man1a1 mannosidase, alpha, class 1A, member 15.19E-05 -2.97962 2.90E-06 -5.01613 0.116884 -1.27853 0.000585 -2.15238

Cyr61 cysteine-rich, angiogenic inducer, 610.386552 1.38006 0.088961 -1.97548 0.529383 1.26016 0.059558 -2.16344

Cryab crystallin, alpha B 0.831977 -1.11304 0.210798 -1.9437 0.672085 -1.23937 0.152659 -2.16431

Nr4a3 nuclear receptor subfamily 4, group A, member 30.0017434 2.328 0.815467 -1.04525 0.544558 1.12311 0.002941 -2.16661

SH3GLB1 SH3-domain GRB2-like endophilin B10.0018279 -2.50953 9.10E-05 -4.27621 0.265142 -1.27287 0.004913 -2.16896

LOC684871 similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1)0.0019884 5.12729 0.052963 2.27797 0.922056 1.03731 0.065272 -2.16985

LOC680687 Hypothetical protein LOC6806870.639805 -1.38225 0.778158 -1.21407 0.211207 -2.47116 0.277904 -2.17049

LOC679578 similar to Protein C18orf18.95E-06 6.01183 0.000145 3.38655 0.289943 -1.22716 0.00258 -2.17847

Smox spermine oxidase 0.0003008 2.28945 0.054059 1.36083 0.093396 -1.29696 0.000448 -2.18198

Guca1a guanylate cyclase activator 1a (retina)0.82768 1.03808 0.9352 -1.01404 0.002274 -2.07863 0.001516 -2.18807

Scpep1 serine carboxypeptidase 10.0076926 1.49288 0.010211 1.4607 0.000148 -2.14529 0.000122 -2.19256

Cxcr4 chemokine (C-X-C motif) receptor 40.0001892 7.4031 0.00294 3.6654 0.795018 -1.08632 0.034218 -2.19408

Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d3.80E-06 6.50905 0.000251 2.85421 0.832505 1.03747 0.001585 -2.19814

RGD1563510similar to RIKEN cDNA 8430427H17 gene0.0023783 -1.92981 1.29E-05 -4.14532 0.879761 -1.02377 0.000784 -2.1991

Rtn4r reticulon 4 receptor 7.28E-05 3.63137 0.005696 1.91145 0.420594 -1.15837 0.001863 -2.20067

Gclc glutamate-cysteine ligase, catalytic subunit0.256437 -1.2201 0.198773 -1.25616 0.001601 -2.1389 0.001272 -2.20211

Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 80.0001328 2.82181 0.386077 1.14925 0.506796 1.1112 0.000798 -2.20964

Ano1 anoctamin 1, calcium activated chloride channel2.48E-05 6.27847 0.001182 2.83577 0.998441 1.00043 0.005703 -2.21308

Gfpt2 glutamine-fructose-6-phosphate transaminase 20.0002766 4.97762 0.009228 2.43775 0.762686 -1.08508 0.015965 -2.21562

Cadps Ca++-dependent secretion activator3.28E-07 4.06522 0.00094 1.59397 0.164094 1.15058 2.39E-05 -2.21659


of 148 Diabetes

Col1a2 collagen, type I, alpha 20.0015315 3.10301 0.228159 1.36902 0.936278 1.02005 0.01058 -2.22204

SPAG9 sperm associated antigen 90.0568439 1.68588 0.413416 -1.2246 0.76212 -1.07634 0.009364 -2.22214

Maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.184755 -1.32187 0.003228 -2.21917 0.178738 -1.32763 0.003129 -2.22884

Snx14 sorting nexin 14 0.042402 -1.19301 0.002173 -1.38373 1.93E-05 -1.9252 4.21E-06 -2.23297

Itga1 integrin, alpha 1 0.0095788 3.31966 0.390084 1.38008 0.839602 1.07695 0.053166 -2.23355

Nr4a2 nuclear receptor subfamily 4, group A, member 20.643396 -1.21588 0.010314 -3.87708 0.406947 1.42715 0.083266 -2.23432

Smox spermine oxidase 0.0214181 1.70041 0.882515 -1.02881 0.224553 -1.27764 0.002544 -2.2351

Tslp thymic stromal lymphopoietin4.61E-05 3.39262 0.090098 1.34521 0.472298 1.12306 0.000767 -2.24564

Fosl1 fos-like antigen 1 4.08E-06 20.8162 5.66E-05 8.37069 0.720746 1.10737 0.018779 -2.24567

Susd2 sushi domain containing 20.0122987 1.94729 0.387619 1.20838 0.145685 -1.39642 0.00445 -2.25031

Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b3.11E-05 8.13186 0.000996 3.52953 0.928688 1.02336 0.011768 -2.25136

Ckb creatine kinase, brain 0.0039214 3.02308 0.125393 1.60428 0.533552 -1.19686 0.018582 -2.25534

Nr4a1 nuclear receptor subfamily 4, group A, member 10.146574 2.80326 0.802833 1.17998 0.938072 1.05275 0.239984 -2.25666

Baalc brain and acute leukemia, cytoplasmic2.01E-06 8.5005 7.09E-05 3.75228 0.986029 1.0032 0.001744 -2.2582

Lzts1 leucine zipper, putative tumor suppressor 19.44E-06 2.36243 0.02277 1.27793 0.046876 -1.22717 1.35E-05 -2.2686

Rnase4 ribonuclease, RNase A family 40.0431044 2.70445 0.250578 1.67071 0.437394 -1.40308 0.083081 -2.27123

Btg2 BTG family, member 2 0.0658685 3.21192 0.628404 1.31751 0.901302 1.07267 0.172489 -2.27271

Thbd thrombomodulin 0.0018853 5.64297 0.078512 2.15448 0.719524 1.15215 0.063055 -2.2733

Gramd1c GRAM domain containing 1C4.90E-05 -6.10673 6.86E-06 -10.6374 0.279692 -1.30535 0.007247 -2.2738

Scg5 secretogranin V 4.80E-06 -6.8152 2.53E-07 -16.7166 0.687314 1.07707 0.001694 -2.27731

Cps1 Carbamoyl-phosphate synthetase 19.37E-07 -41.3155 7.29E-07 -46.7474 0.03603 -2.01439 0.018151 -2.27923

Nt5e 5' nucleotidase, ecto 6.99E-07 16.8122 4.65E-06 9.03907 0.344289 -1.22656 0.003637 -2.28134

Krt10 keratin 10 5.15E-05 6.28841 0.001341 3.09856 0.629845 -1.12506 0.007958 -2.28328

Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)2.06E-05 14.4249 0.000366 5.88082 0.819661 1.07343 0.025149 -2.28507

Aspn Asporin 0.0119816 3.81761 0.199603 1.7845 0.870114 -1.07244 0.079915 -2.29428

Ptrh1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)0.0159224 1.67748 0.578028 -1.10348 0.240809 -1.24008 0.001205 -2.29547

LOC100362331rCG59612-like 0.0930377 1.39191 0.053978 -1.47915 0.544954 -1.11588 0.001363 -2.29741

Col12a1 collagen, type XII, alpha 10.0031979 5.82385 0.882348 -1.06698 0.047762 2.69369 0.084349 -2.30684

Ctsf cathepsin F 0.000439 -2.21164 7.28E-06 -4.11184 0.150278 -1.24656 0.0003 -2.31758

Cast calpastatin 0.0013926 -2.14429 2.73E-05 -3.90691 0.164206 -1.27691 0.000737 -2.32654

Csrnp1 cysteine-serine-rich nuclear protein 10.879415 1.05571 0.033089 -2.43452 0.78257 1.10383 0.04044 -2.32838

RGD1563091similar to OEF2 0.0144852 -1.63919 9.48E-05 -3.12916 0.240032 -1.22362 0.000698 -2.33584

Nrep neuronal regeneration related protein0.0675206 -2.81652 0.002137 -8.85347 0.56354 1.3434 0.120965 -2.33989

Rtn4r reticulon 4 receptor 0.0001316 3.30986 0.016535 1.69588 0.324132 -1.20165 0.001232 -2.34527

P4ha3 Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polype0.003661 3.39756 0.377037 1.32593 0.778062 1.09192 0.022225 -2.34669

of 148Diabetes

Ropn1l ropporin 1-like 1.75E-05 2.83544 0.005603 1.53899 0.066246 -1.27659 7.30E-05 -2.352

Mmp3 matrix metallopeptidase 31.03E-06 63.0877 3.95E-06 32.3506 0.559175 -1.21089 0.025594 -2.36139


Bean brain expressed, associated with Nedd47.21E-06 3.39416 0.00814 1.51871 0.626989 -1.06227 8.97E-05 -2.37408

Trio Triple functional domain (PTPRF interacting)7.94E-05 2.53483 0.02449 1.41848 0.054659 -1.3289 0.000132 -2.37475

Crem cAMP responsive element modulator0.0011158 2.49735 0.310315 1.22155 0.440596 -1.16174 0.001578 -2.37507


Slc15a2 solute carrier family 15 (H+/peptide transporter), member 29.27E-06 5.95584 5.97E-05 3.98549 0.03249 -1.59404 0.001343 -2.38211

SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 70.0167493 2.17014 0.456391 1.22297 0.278995 -1.34807 0.009483 -2.39214

Ccbl1 cysteine conjugate-beta lyase, cytoplasmic0.0005804 2.97779 0.052629 1.57113 0.267988 -1.26694 0.002264 -2.40126

Rnase4 ribonuclease, RNase A family 40.0209248 2.73657 0.21625 1.60229 0.356413 -1.41007 0.036766 -2.40828


Cd55 Cd55 molecule 0.818355 -1.13882 0.04041 -3.81049 0.569737 1.38353 0.145543 -2.41843

Plaur plasminogen activator, urokinase receptor8.37E-05 5.11691 0.000159 4.43427 0.010484 -2.10228 0.004153 -2.42593

Col1a2 collagen, type I, alpha 2 8.44E-05 2.57372 0.617272 -1.0697 0.361774 1.13356 0.000132 -2.42872

RGD1562284similar to Glutaminyl-peptide cyclotransferase precursor (QC)0.0001114 8.06776 0.007023 2.91812 0.67799 1.13689 0.017497 -2.43182

Slc41a2 Solute carrier family 41, member 20.011724 -1.4142 4.61E-06 -3.18066 0.383673 -1.10331 2.77E-05 -2.48145


Adamts9 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 mot0.0897577 1.8628 0.644757 -1.16697 0.674224 -1.15098 0.021647 -2.50204

Lancl1 LanC lantibiotic synthetase component C-like 1 (bacterial)0.0005058 -4.2216 4.15E-05 -7.92019 0.291451 -1.33653 0.007197 -2.50748

Gpr64 G protein-coupled receptor 647.43E-05 3.3604 0.077075 1.39243 0.81169 -1.04101 0.000485 -2.51231

LOC100910237uncharacterized LOC1009102370.586325 -1.29777 0.211904 -1.866 0.253639 -1.76037 0.078079 -2.53114


Gadd45g growth arrest and DNA-damage-inducible, gamma0.0074696 2.18186 0.733406 1.08052 0.328871 -1.25642 0.002835 -2.53705

Cd55 Cd55 molecule 0.931737 1.05131 0.048921 -3.71845 0.481416 1.51885 0.133456 -2.57383


PAK3 p21 protein (Cdc42/Rac)-activated kinase 34.05E-07 5.72566 5.66E-05 2.4684 0.33394 -1.12795 3.61E-05 -2.61637

Cdh2 cadherin 2 0.0507854 2.59971 0.881711 -1.06601 0.914421 1.04723 0.047509 -2.64633

Rhpn2 rhophilin, Rho GTPase binding protein 20.0069169 -2.86561 0.001047 -4.30934 0.086191 -1.77 0.010026 -2.66175

Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b0.0197376 3.13795 0.617058 1.22721 0.915988 -1.04379 0.0373 -2.66893

Mmp13 matrix metallopeptidase 130.0015067 48.8553 0.008079 17.906 0.981181 1.02026 0.266933 -2.67424

Mtmr1 Myotubularin related protein 10.326074 -1.37188 0.792131 -1.08585 0.003785 -3.38115 0.011579 -2.6762

Wnt2 wingless-type MMTV integration site family member 20.0054798 -4.57069 0.000344 -10.9909 0.796476 -1.11354 0.04042 -2.67767

Ttll7 tubulin tyrosine ligase-like family, member 71.09E-05 2.283 0.1415 -1.14947 0.731799 -1.03078 2.68E-06 -2.70502

Wnt2 wingless-type MMTV integration site family member 20.0054392 -3.68964 0.000216 -9.0529 0.784275 -1.10291 0.020596 -2.7061

of 148 Diabetes

Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 81.53E-05 3.57595 0.120365 1.27089 0.792028 1.03832 8.99E-05 -2.7099

LOC690768 Hypothetical protein LOC6907680.747162 1.2377 0.336078 1.92309 0.054394 -4.21666 0.15682 -2.71385

Plcxd3 phosphatidylinositol-specific phospholipase C, X domain containing 30.469991 1.30717 0.239393 -1.56673 0.437669 -1.33445 0.021601 -2.73294


Tgfb2 transforming growth factor, beta 20.0132755 4.78235 0.274736 1.78524 0.938831 -1.03992 0.071932 -2.78575

Rgc32 response gene to complement 320.0002063 5.19833 0.126755 1.54965 0.495361 1.20153 0.003981 -2.79187

Tagln transgelin 5.64E-06 6.71121 0.000675 2.62965 0.628214 -1.095 0.000454 -2.79458

Tm4sf1 transmembrane 4 L six family member 10.002011 17.0899 0.027423 5.46924 0.870712 1.11191 0.140294 -2.81023

Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 10.0006144 7.68737 0.038061 2.53391 0.844716 1.07877 0.024714 -2.81227

Snca synuclein, alpha (non A4 component of amyloid precursor)0.0909306 -1.70413 0.001674 -3.6194 0.340351 -1.32482 0.005798 -2.81377

RGD1561238similar to ring finger protein 122 homolog0.216834 1.55127 0.041833 -2.20916 0.566843 1.21604 0.01332 -2.81816

Dguok deoxyguanosine kinase 0.546947 -1.41436 0.185816 -2.22079 0.31678 -1.80148 0.095978 -2.82862

Tfpi tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.0150734 -2.6427 0.000432 -6.11686 0.528236 -1.23107 0.010528 -2.84947

Hspa1a heat shock 70kD protein 1A0.647185 -1.18663 0.013973 -3.08707 0.806668 -1.09532 0.019604 -2.84954

Fgf13 fibroblast growth factor 136.03E-05 2.32206 0.704216 1.0443 0.052212 -1.28526 1.21E-05 -2.85785

SLC5A8 solute carrier family 5 (iodide transporter), member 80.0007341 3.41499 0.049117 1.71202 0.158995 -1.43383 0.001926 -2.86008

Rgs2 regulator of G-protein signaling 20.622118 1.37982 0.056939 -4.03988 0.329019 1.92108 0.128346 -2.90166

C1ql3 complement component 1, q subcomponent-like 30.0010524 -2.7088 0.232721 1.29344 2.65E-06 -10.2384 0.000661 -2.9222

Col5a2 collagen, type V, alpha 20.0095192 5.2135 0.251896 1.82535 0.962113 -1.02417 0.058745 -2.9252

Spon1 spondin 1, extracellular matrix protein0.0001007 3.68488 0.186626 1.30324 0.853062 -1.0357 0.000379 -2.92842

Ccdc80 coiled-coil domain containing 800.0004465 4.92438 0.091699 1.70644 0.94956 -1.01837 0.004777 -2.93879

Mapre3 Microtubule-associated protein, RP/EB family, member 30.817076 1.05861 0.002985 -2.72185 0.914851 -1.02664 0.001869 -2.95813

Fn1 fibronectin 1 5.04E-07 76.0987 5.34E-06 24.0634 0.83574 1.06614 0.006623 -2.96623

Hpse heparanase 0.680542 1.11584 0.373668 -1.2735 0.020891 -2.08745 0.002848 -2.96629

Akr1c18 aldo-keto reductase family 1, member C180.102368 -1.62188 0.000548 -4.27391 0.648901 -1.13202 0.00313 -2.98305

Pcdhb13 protocadherin beta 13 0.0004629 2.1957 0.037113 1.41272 0.001419 -1.93335 4.56E-05 -3.00488

Rapgef4 Rap guanine nucleotide exchange factor (GEF) 40.0008253 11.1681 0.029084 3.42868 0.891448 1.0676 0.043012 -3.051

Pvrl3 poliovirus receptor-related 34.42E-07 37.7558 1.42E-05 9.95504 0.406439 1.24095 0.001913 -3.05623

Tnrc6a Trinucleotide repeat containing 6a0.403401 1.15415 0.42801 -1.14531 0.000817 -2.33034 0.000122 -3.0804

Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)2.05E-06 8.28438 0.000516 2.66326 0.99306 -1.00157 0.000191 -3.11551

Btg2 BTG family, member 2 0.0075103 4.48234 0.356188 1.51251 0.904112 -1.05395 0.027279 -3.12339

Chrnb4 cholinergic receptor, nicotinic, beta 42.70E-06 13.6789 4.25E-05 6.07195 0.168463 -1.40514 0.000897 -3.16549

Tgfb2 Transforming growth factor, beta 20.0123141 5.49194 0.431303 1.55102 0.8651 1.09737 0.057918 -3.22669

Rgs2 regulator of G-protein signaling 20.858066 1.12007 0.042936 -4.37391 0.522467 1.5077 0.091186 -3.24937

Gpm6a glycoprotein m6a 0.000105 -35.599 0.000216 -24.9721 0.015797 -4.6711 0.046741 -3.2767

of 148Diabetes

Crem cAMP responsive element modulator1.41E-05 3.57378 0.377092 1.13601 0.772568 -1.04162 2.37E-05 -3.27682

Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member0.0143549 5.15407 0.334994 1.71627 0.865577 -1.09641 0.053459 -3.29261

Nr4a3 nuclear receptor subfamily 4, group A, member 30.0010002 4.98836 0.461864 1.27936 0.647154 1.16367 0.00529 -3.35067

Dclk1 doublecortin-like kinase 10.0209186 -3.50477 0.001014 -9.02571 0.545462 -1.31802 0.023415 -3.39424

Filip1l filamin A interacting protein 1-like3.03E-07 21.6655 1.27E-05 6.58256 0.782847 -1.05831 0.000239 -3.48328

Syt16 Synaptotagmin XVI 0.549452 1.13594 0.316667 -1.24341 0.002136 -2.47921 0.000276 -3.50174

Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 46.94E-05 30.4323 0.001222 9.24097 0.894824 -1.06413 0.024942 -3.5044

Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 11.81E-05 54.4745 0.000199 17.3783 0.782733 -1.13464 0.020997 -3.55668

Dclk1 doublecortin-like kinase 10.0633173 -2.24331 0.00107 -6.48839 0.557266 -1.25815 0.008763 -3.639

Hspb8 heat shock protein B8 1.36E-05 8.37692 0.024772 1.8668 0.425225 1.20948 0.000409 -3.71012

Abhd3 abhydrolase domain containing 30.118327 -1.52294 0.001082 -3.30973 0.05446 -1.71823 0.000588 -3.73413


Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 13.55E-05 39.665 0.000345 14.2366 0.505587 -1.36549 0.017351 -3.80443

Lum lumican 0.0007983 3.92102 0.8946 1.03641 0.968124 -1.01084 0.000897 -3.82427

Tgfb2 Transforming growth factor, beta 20.018473 6.49337 0.50067 1.56439 0.901208 1.0847 0.067353 -3.82662

Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 22.14E-10 563.839 1.87E-09 124.377 0.348487 1.17657 3.46E-05 -3.853

Pvrl3 Poliovirus receptor-related 31.58E-07 23.4761 1.38E-05 5.79405 0.850129 1.03728 8.68E-05 -3.90613

Pmp22 peripheral myelin protein 220.0003384 7.84143 0.018762 2.76034 0.380986 -1.37766 0.004246 -3.91358

Lgals1 lectin, galactoside-binding, soluble, 10.0468214 3.26742 0.824647 1.12238 0.57265 -1.34524 0.026771 -3.91622

Mmp12 matrix metallopeptidase 122.11E-05 11.2563 0.003989 2.98292 0.887054 -1.04095 0.001055 -3.92812

Dusp1 dual specificity phosphatase 10.112711 2.21373 0.514814 -1.35527 0.530193 -1.34 0.014252 -4.0203


Pxdn peroxidasin homolog (Drosophila)1.83E-06 93.0483 2.65E-05 23.8387 0.868274 -1.06543 0.004869 -4.15862

Tnc Tenascin C 5.27E-08 266.987 6.92E-07 55.3891 0.624606 1.15821 0.001135 -4.16177

LOC100360880FBJ osteosarcoma oncogene B0.0405227 5.30435 0.751582 -1.25107 0.519023 1.58581 0.069601 -4.18468

Hspb8 heat shock protein B8 4.87E-06 20.875 0.004719 2.98295 0.106505 1.67046 0.000957 -4.18931

Wnt2 Wingless-type MMTV integration site family member 20.0102182 -5.24532 0.000251 -21.9915 0.982559 -1.01125 0.019534 -4.23977

Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 24.53E-07 6.24325 0.23507 1.17364 0.119112 1.24309 2.67E-06 -4.27932

Adm adrenomedullin 0.0910341 2.30454 0.708674 -1.18333 0.263974 -1.68578 0.007971 -4.59718

Aldh1a7 aldehyde dehydrogenase family 1, subfamily A70.486855 2.52634 0.218849 5.45472 0.103146 -10.3679 0.252224 -4.80184


Ctgf connective tissue growth factor0.890199 1.11045 0.012534 -10.5438 0.316426 2.19371 0.052231 -5.33724

Postn periostin, osteoblast specific factor0.0099467 3.77119 0.893837 -1.05595 0.456266 -1.36255 0.002689 -5.42593

Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.0020944 12.2261 0.372559 1.69804 0.848998 1.11655 0.010465 -6.44852

CALD1 caldesmon 1 0.0001031 21.775 0.028246 3.19471 0.993742 1.00352 0.002262 -6.79205

of 148 Diabetes

Tmem35 transmembrane protein 350.0001187 9.19304 0.454327 1.28543 0.874996 -1.05323 0.000227 -7.53245

Atf3 activating transcription factor 30.0005392 21.2662 0.142559 2.44809 0.807434 1.14879 0.006267 -7.56173

Vim vimentin 9.08E-06 29.2498 0.000959 5.63419 0.170107 -1.67122 0.000222 -8.67609

of 148Diabetes

Page 1 of 148 Diabetes...in DM and NL rat CECs. We identified 1888 probe sets with more than...

Documents

Transcript of Page 1 of 148 Diabetes...in DM and NL rat CECs. We identified 1888 probe sets with more than...