Dr. Stephen PadgetteVP & Global Biotechnology Lead, Monsanto

Global Demand For Food, Feed and Fuel Continues to Grow

Sources: FAO “World Agriculture: towards 2015/2030. Summary Report”; IHS Global Insights , Agriculture Division

GROWING WORLD POPULATION

1

2

3

4

5

6

7

8

9

1981 1999 2015 2030

TRANSITION NATIONS

DEVELOPED NATIONS

DEVELOPING NATIONS

2000 2010 2015 2020 20300

500

1,000

1,500

2,000

2,500

3,000

RiceCottonSoy-beansWheatCorn

GLOBAL GRAIN DEMAND

+102%

+40%

+76%

+28%

+125%

2

Technological Innovation is Key to Meeting Future Grain Demand

DOUBLING YIELD WITH TECHNOLOGY:U.S. CORN EXAMPLE

30

40

50

60

70

80

90

2000 2005 2010 2015 2020 2025 2030

U.S. 2030 SOYBEAN YIELD TARGET2030: >2X 2000 BASELINE OF

38 BUSHELS PER ACRE

DOUBLING YIELD WITH TECHNOLOGY:U.S. SOYBEAN EXAMPLE

BUSH

ELS

PER

ACRE

120140160180200220240260280300

2000 2005 2010 2015 2020 2025 2030

BUSH

ELS

PER

ACRE

HISTORIC YIELD GAIN AG PRACTICE IMPROVEMENTSBREEDING IMPROVEMENTSBIOTECH IMPROVEMENTS

HISTORIC YIELD GAIN AG PRACTICE IMPROVEMENTSBREEDING IMPROVEMENTSBIOTECH IMPROVEMENTS

U.S. 2030 CORN YIELD TARGET2030: >2X 2000 BASELINE OF

137 BUSHELS PER ACRE

FAPRI 2008 World Agricultural Outlook; Global Insights International Crops Forecast October 20083

14 MILLION FARMERS GREW BIOTECH CROPS IN 2009 ON 331 M ACRES

Biotechnology is the Most Rapidly Adopted New Crop Technology

• Proven economic

and environmental

benefits

• Solid record of safety

• Promising future

benefits from new

products and

technologies

SOURCE: ISAAA estimates

020406080

100120140160180200220240260280300320340360

Canola Cotton

Corn Soybeans

Acres

4

Emerging Crop Technologies are Poised to Help Address Global Challenges

Agriculture’s Environmental Footprint

•Nitrogen-Use efficiency crops

Global Food Security•Enhanced productivity•Higher-Yielding crops•Sustainable production

Water Availability• Drought-tolerant crops• Partnering to share

technology with developing world farmers

Biofuel Demands • Yield technologies to help

meet demand for both food and fuel

Healthier Diets•High oleic fats•Omega-3 Soybeans

Commercialization depends on many factors, including successful conclusion of the regulatory process.

5

Quality Seed and Innovative Methods are Revolutionizing Plant Breeding

• Our breeders exchange 1M+ different “packages” of germplasm material annually

• >50% of Monsanto’s corn hybrids result from intra-company crosses

MOLECULAR BREEDING Accelerates the Rate of Gain

Soybean Seed Chipper

Automated Marker Analysis

• Capability to analyze 10s of millions of samples

• Over 40 million marker-trait associations provide detailed genome understanding

SEED GERMPLASM LIBRARY Our Building Block for Better Breeding

6

Precision Agriculture Optimizes the Field

Geographical Information Systems

GPS-enabled satellite imaging of agricultural fields

SoilType, texture, etc. affect productivity

SeedGenetics, optimal population & row spacing

Twin Row SpacingSingle Row Spacing

Input ManagementPrecise management of fertilizers, water, etc.

AgronomyConservation tillage, carbon sequestration

Equipment Automation

7

1995

Productive Collaborations are Crucial to Deliver Continued Innovation

8

Land O’Lakes;Forage Genetics Int’l.

Danforth Center

Solae Company

GrassRoots Biotechnology

Dole Food Co.

Protabit, LLC

Illumina, Inc.

Pacific Biosciences

AgraQuest, Inc.

Evogene Ltd.

Devgen NV

BASF

Stokes Bio

Cellectis

Hexima, Ltd.

TwistDx, Ltd.

MendelBiotechnology, Inc.

Arcadia Biosciences, Inc.

Chromatin, Inc.

Senesco Technologies, Inc.

Huazhong Ag. Univ.

Hunan Univ.

NC ResearchCampus

(Kannapolis) MON Beijing R&D Center

MON Bangalore R&D Center

MON Campinas R&D Center

MON U.S. R&D Centers Top 16 Plant Science Institutions

UCD

Minnesota, U Wisc., Illinois, & Missouri U Wageningen

INRA

Chinese Acad. of Sci. & Chinese Acad. AG Sci.

U TokyoOhio State

Cornell

Harvard

RIKEN

UCRUCB

Agronomic TraitsTransformation & Trait Dev.Plant Breeding & GenomicsYield & Stress

Diameter of bubbles proportional to number of pubs & citations

Steve Padgette, Ph.D.

Vice President Biotechnology, Monsanto

Thank You