Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose...
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![Page 1: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/1.jpg)
Pachymetric changes during corneal collagen cross-linking and
effect of hydroxipropylmethylcellulose on
corneal thickness
Faik Oruçoğlu(Orucov)
Kudret Eye Hospital / Istanbul
![Page 2: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/2.jpg)
Purpose
To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.
![Page 3: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/3.jpg)
Hydroxipropylmethylcellulose
Hypromellose• Hydrophylic• pH: 7,2-7,9• Osmolarity 240-300 mOsm
![Page 4: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/4.jpg)
![Page 5: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/5.jpg)
Spoerl E,.Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007;26:385–9
Ophthalmology 2009; 116(12) 2336-9
![Page 6: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/6.jpg)
Methods
Grup 1. (N=18). • Epithelial abrasion (9mm)• 0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes. • UVA 3mw/cm2 at 365nm for 30 min
Grup 2. (N=21). • Epithelial abrasion (9mm)• 0.1 % Riboflavin drops in dextrane every 3 minutes and
hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes. • UVA 3mw/cm2 at 365nm for 30 min
Two groups were formed in patients with keratoconus undergoing cross-linking ;
![Page 7: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/7.jpg)
Central corneal thicknesses were measured by ultrasound pachimetry
– before epithelial abrasion, – after epithelial abrasion and – 30 minutes after beginning riboflavin installation
![Page 8: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/8.jpg)
Before epithelial abrasion After epithelial abrasion P
Grup 1 457.2 + 62.6 395±54,9 <0,001
Grup 2 449.7 + 62.6 389,4±44,2 0,009
After epithelial abrasion 30 minutes after riboflavin installation
P
Grup 1 395±54,9 360±44,4 <0,001
Grup 2 389,4±44,2 374,4±38,1 0,08
450
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Group 1
Group 2
After epithelial abrasion 30 minutes after riboflavin
![Page 9: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/9.jpg)
Conclusion Decrease of corneal thickness continues with
epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC.
Rb+Dextran H2O Rb+Dextran H2OHPMC
![Page 10: Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret.](https://reader034.fdocuments.in/reader034/viewer/2022051315/56649ef65503460f94c0a040/html5/thumbnails/10.jpg)
Thank you for your attention