p53 pathway - Abcamdocs.abcam.com/pdf/nuclearsignal/p53_pathway.pdf1 6 3-1 0 / 1 0-P W p53...
Transcript of p53 pathway - Abcamdocs.abcam.com/pdf/nuclearsignal/p53_pathway.pdf1 6 3-1 0 / 1 0-P W p53...
DNA damage
Growthfactor
Siah1
HipK2
Tip60
Set7/9
Chk1
DAPK
CK1
DNA-PK
ATR
p38ERK
MK5/PRAK
AMPK
p38
TAG
PP1
Wip1
ATM
acK
acK
CARM1
PRMT1
p18/hamlet
cdk8
Axin
BRN-3b
LSD1
Pin1
iASPP
YY1
ASPP1/2
p52
p66shc Pig3 Pig6
Bax Bak
Bcl-2 IAP1 IAP2
Blk Puma Noxa
CDIP DR5 FAS
maspin TSP1 BAI-1
GADD45A 14.3.3s FBXW7
XPC p53R2 DDB2
PHLDA3 PTEN IGFBP3
Dram
gpx1 Aldh4 p53Dinp1
BTG2 p21 PAI-1 Dec1
AMPKb1/2 Sestrin 1/2 Redd1 TSC2
Tigar GLS2 GAMT Sco2
HDAC1
Sin3AATM
Sirt1
pCAF
PML
p68
BRCA1
BRN-3achk2
PRMT5
JMY
E4F1
Hzf
hnRNPK
p300/CBPMdmx
Smyd2
Set8
chip
ARFBP1
p14ARF
Hausp
Mdm2
AKT
MdmxATR
ATM
Wig1
Pirh2
Ub
Ub Ub
Ub
meR
S33
S37
meK
meK
meK
meK
S46
S20
S15p53p53
UbUb
UbUb
Ub
Ub
p53
p53
p53
Strap
Oncogene
Metabolic stress
mRNA
mRNA
Angiogenesis
G2/M transition
Cell cycle arrestSenescence
Cell growthinhibition
Metabolicstress
adaptation
G1/S transition
DNA repair
mTOR
AKT
NADPH/ATPproduction
ROSproduction
Autophagy
Viral infection
DNA damage
Oncogene
Oncogene
Nucleolardisruption
Telomereuncapping
p53 mRNAstabilization
nucleolinL26
p53
p53 mRNAtranslation
p53 mRNAdegradation
Apoptosis
L11
L26
L5
CBP
Ub
UbUbUb
UbUb
p53Proteasomaldegradation
Ub
UbUb
p53
Bax
Bcl-2 Smac
IAPs
CytC
Apaf-1
Casp-9
ROS production
Caspase 9activation
Caspase 8activation
Apoptosis
Mito
p53 pathway
www.abcam.comCopyright © 2011 Abcam, All Rights Reserved.
by Arnaud Vigneron, Andreas Hock, Karen Vousden and Abcam
163-10/10-PW
p53 antibodies from Abcam: See more products at: www.abcam.com
Featured antibodies
p53 [PAb 240] (ab26)
Clonality Applications Host Species cross reactivityM ELISA, Flow Cyt, ICC, ICC/IF, Ms Hu, Ms, Rat
IHC (Methanol fixed), IHC-Fr, IHC-P, IP, WB
ATM [2C1 (1A1)] (ab78)
Clonality Applications Host Species cross reactivityM IHC-P, IP, WB Ms Hu, Ms, Rat, Mk
p21 (ab18209)
Clonality Applications Host Species cross reactivityP ICC/IF, IHC-P, WB Rb Hu
Cdk2 (ab64669)
Clonality Applications Host Species cross reactivityP ICC/IF, WB Rb Hu, Rat
HDAC1 (ab19845)
Clonality Applications Host Species cross reactivityP ICC/IF, IHC-P, WB Rb Hu, Ms, Rat
Product Clonality Applications Host Species Datasheet ProteinsReactivity www.abcam.com/ab…
active Caspase 3 P Flow Cyt, ICC, ICC/IF, IHC (PFA fixed), Rb Hu, Ms, Rat, Dm, 13847 52101IHC-FoFr, IHC-Fr, IHC-P, WB InMtj, RMk, Xl, Zfsh
APAF1 M ICC, ICC/IF, IHC-P, WB Rb Hu, Ms 32372 -ATM (phospho S1981) P ICC/IF, WB Rb Hu 79891 -ATR P IF, IP, WB Rb Hu, Ms 2905 -Bax M Flow Cyt, ICC/IF, IP, WB Ms Hu, Ms, Rat 5714 850157Bcl2 P ICC, IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rat, Cow 7973 73696BRCA1 (phospho S1423) P WB Rb Hu 90528 -BRCA1 [MS110] M ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu 16780 82204BRCA2 P IP, WB Rb Hu, Ms 90541 -Chk1 P WB Goat Hu 2845 -Chk1 (phospho S317) P WB Rb Hu, Ms 2834 -Chk2 (phospho T68) P WB Rb Hu 3501 -Chk2 [2CHK01 (DCS-293)] M IF, IP, WB Ms Hu 3292 -Cdk4 P ELISA, IP, WB Rb Hu, Ms, Rat 6551 56281Cdc14A [DCS-291] M ELISA, ICC, IP, WB Ms Hu 10536 -Cdc25A [DCS-120 + DCS-121] M IHC-Fr, IHC-P, IP, WB Ms Hu, Rat 2357 90763Cyclin D1 [CD1.1] M ELISA, Flow Cyt, IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat 6152 85247Cyclin E [HE12] M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB Ms Hu 3927 -DNA PKcs (phospho S2056) - ChIP Grade P ChIP, Flow Cyt, ICC/IF, WB Rb Hu 18192 -
DNA PKcs (phospho T2609) P ICC/IF, WB Rb Hu 4194 -DNA PKcs [Y393] M ICC/IF, IHC-P, WB Rb Hu, Ms, ArHm 32566 -E2F1 [KH95] M IHC-Fr, IHC-P Ms Hu, Ms, Rat 4070 82207E2F2 P WB Chk Hu, Ms 14292 -E2F4 [SPM179] M GSA, IF, IHC-P, WB Ms Hu, Rat 17845 -E2F5 P WB Rb Hu 22855 -E2F6 [TFE61] M ICC/IF, IP, WB Ms Hu 11952 -HIPK2 P ELISA, ICC/IF, IHC-Fr, IHC-P, WB Rb Hu 28507 -JNK1+JNK2 P WB Rb Hu 85139 -KAT2B / PCAF - ChIP Grade P ChIP, IHC-P, IP, WB Rb Hu, Ms, Dog 12188 82074KAT3B / p300 [3G230] - ChIP Grade M ChIP, ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu 14984 82235
MDM2 P ICC/IF, WB Rb Hu 87134 95934MDM2 (phospho S186) [2G2] M WB Ms Hu 22710 -MEK1 P ICC/IF, WB Rb Hu, Ms, Rat 42647 63209MEK1 (phospho T386) P WB Rb Hu, Ms, Rat 5615 -MEK3 P IP, WB Rb Hu 2565 -MEK7 P ICC, IF, WB Rb Hu, Ms 18565 -MEK7 (phospho S271 + T275) P WB Rb Hu 4762 -p38 P ICC, ICC/IF, IHC-Fr, IHC-FrFl, IHC-P, IP, WB Rb Hu, Ms, Rat 7952 45158p53 (phospho S15) P ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat 1431 -PCNA - Proliferation Marker [PC10] M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rat, Chk, Dm, Zfsh 29 85651PKC gamma P ELISA, ICC, IHC-Fr, WB Rb Rat 4145 60842PKC gamma (phospho T674) P WB Rb Hu, Rat 5797 -Raf1 (phospho S621) P WB Rb Hu 4767 -Raf1 [Y198] M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat 32025 62292SIRT1 P ICC/IF, IP, WB Rb Hu 7343 101130SIRT2 - Nuclear Marker P WB Rb Hu 10659 101132SIRT3 P WB Rb Hu 40963 54333