P12-19
1
pH 0 2 4 6 8 10 12 14 Zeta Potential (mV) -60 -40 -20 0 20 40 60 80 COO - NH 3+ Synthesis and functionalization of magnetic and metallic nanoparticles for biological and environmental applications Adriana P. Herrera, PhD University of Cartagena, Colombia Department of Chemical Engineering. Piedra de Bolivar, Avenida del Consulado #34-100 [email protected] References FTIR spectra of a) magnetite nanoparticles coated with APS molecules, b) magnetite-APS/CMDx and c) magnetite-APS/PEG. Abstract Magnetic and metallic nanoparticles are the subject of intense research focusing on their synthesis, characterization, and functionalization. These nanomaterials are attractive in various novel applications including: nano-/bio-sensors, catalyst recovery, antimicrobial, and separation of pollutants, among other. These applications require suitable nanoparticle surface modification, which provides colloidal stability in aqueous or biological fluids and improves the nanoparticle's transport and retention in specific areas. Synthesis of Nanoparticles Zeta potential measurements: Herrera, A. et al., Journal of Materials Chemistry, vol. 18, pp. 3650- 3654, 2008. Barrera, C. et al., Journal of Colloid and Interface Science, vol. 329, pp. 107-113, 2009. Herrera, A. et al., Nanotechnology vol. 16, p.p S618–S625, 2005. Bao, L. et al., Chemistry of Materials, vol. 21, pp. 3458-3468, 2009. Polking, M. et al., Journal of the American Chemical Society, vol. 133, pp. 2044-2047, 2011. Surface modification of magnetite-APS nanoparticles with CMDx or PEG Sample pI Mag-APS 10 Mag- APS/CMDX 3.0 Mag- APS/PEG 7.5 Zeta potential measurements of magnetite- APS/CMDx nanoparticles with NaCl at pH 7.0 To control particle size and distribution the thermal- decomposition technique is used employing high boiling solvents such as 1-octadecene to separate the nucleation and growth stages during particle synthesis. TEM measurement of magnetite nanoparticles with a D pgv of 13 nm and g of 0.19 synthesized in 1-octadecene using oleic acid (OA) as a surfactant Thermal-decomposition: Co-precipitation: The most common method to synthesize magnetic nanoparticles is the co-precipitation of aqueous iron salts in presence of strong bases such as ammonium hydroxide or sodium hydroxide. This chemical precipitation allows a large scale synthesis of magnetic nanoparticles easily and economically. Typically the co-precipitation route yields magnetic nanoparticles with a polydisperse size distribution and results in formation of cluster-like aggregates. Representation of the micellar exchange process for the synthesis of gold nanoparticles in the water/AOT/Isooctane system Reverse micelle structure and relationship D h vs w 6.61 0.298 h D w Reverse Micelles: Using reverse micelles for nanostructure synthesis takes advantage of the small size of the micellar water pools, which essentially act as nanoreactors that collide and exchange contents. Reverse micelles consist of aqueous droplets that are separated from the bulk organic phase by a surfactant layer. The diameter (D h ) of these droplets greatly influences the size of the resulting nanoparticles; we found by Dynamic Light Scattering (DLS) measurements, that this value is dependent on the water-surfactant molar ratio (w) selected for the system water/AOT/Isooctane : Characterization Fourier Transform Infrared spectroscopy: (nm) 400 450 500 550 600 650 700 Normalized absorptio 0.0 0.2 0.4 0.6 0.8 1.0 1.2 5 nm 10 nm 15 nm 20 nm 30 nm 40 nm 50 nm 60 nm 80 nm 100 nm (nm) 300 400 500 600 700 Normalized absorption 0.5 1.0 1.5 2.0 2.5 w10-10 nm w10-30 nm w10-50 nm w10-80 nm w10-100 nm a) Gold colloids absorption in aqueous medium b) Gold colloids absorption in w10 system Optical properties of gold nanoparticles: Potential Applications of Nanoparticles Synthesis of silver nanoparticles by using leaves extracts of cilantro (Coriandrum sativum) Surface modification with cellulose Evaluation of the antimicrobial action of silver nanoparticles modified with cellulose after contact with E. coli bacteria Antimicrobial application of silver nanoparticles modified with cellulose for the production of active food packs Modified nanoparticles Synthesis of magnetic nanoparticles modified with TiO 2 for photodegradation of phenol in aqueous solutions Local generation of heat in cancerous cells with AC magnetic field. Biocompatible magnetic nanoparticles inside cancer cells. Application of an AC magnetic field. Temperature rise to ~46 °C Destruction of cancer cell 37 °C ~ 46 °C
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Transcript of P12-19
pH
0 2 4 6 8 10 12 14
Zeta
Po
ten
tial
(mV
)
-60
-40
-20
0
20
40
60
80
Fe3
O4 - APS
Fe3
O4 - APS/CMDx
Fe3
O4 - APS/PEG
COO-
NH3+
Synthesis and functionalization of magnetic and metallic nanoparticles for biological and
environmental applicationsAdriana P. Herrera, PhD
University of Cartagena, ColombiaDepartment of Chemical Engineering. Piedra de Bolivar, Avenida del Consulado #34-100
References
FTIR spectra of a) magnetite nanoparticles coatedwith APS molecules, b) magnetite-APS/CMDx andc) magnetite-APS/PEG.
Abstract
Magnetic and metallic nanoparticles are the subject ofintense research focusing on their synthesis,characterization, and functionalization. Thesenanomaterials are attractive in various novel applicationsincluding: nano-/bio-sensors, catalyst recovery,antimicrobial, and separation of pollutants, among other.These applications require suitable nanoparticle surfacemodification, which provides colloidal stability in aqueousor biological fluids and improves the nanoparticle'stransport and retention in specific areas.
Synthesis of Nanoparticles
Zeta potential measurements:
Herrera, A. et al., Journal of Materials Chemistry, vol. 18, pp. 3650-3654, 2008.
Barrera, C. et al., Journal of Colloid and Interface Science, vol. 329,pp. 107-113, 2009.
Herrera, A. et al., Nanotechnology vol. 16, p.p S618–S625, 2005. Bao, L. et al., Chemistry of Materials, vol. 21, pp. 3458-3468, 2009. Polking, M. et al., Journal of the American Chemical Society, vol. 133,
pp. 2044-2047, 2011.
Surface modification of magnetite-APS nanoparticles with CMDx or PEG
Sample pI
Mag-APS 10
Mag-APS/CMDX
3.0
Mag-APS/PEG
7.5
Zeta potential measurements of magnetite-APS/CMDx nanoparticles with NaCl at pH 7.0
To control particle size and distribution the thermal-decomposition technique is used employing high boilingsolvents such as 1-octadecene to separate the nucleationand growth stages during particle synthesis.
TEM measurement of magnetite nanoparticleswith a Dpgv of 13 nm and g of 0.19 synthesized in1-octadecene using oleic acid (OA) as a surfactant
Thermal-decomposition:
Co-precipitation:
The most common method to synthesize magneticnanoparticles is the co-precipitation of aqueous ironsalts in presence of strong bases such as ammoniumhydroxide or sodium hydroxide. This chemicalprecipitation allows a large scale synthesis of magneticnanoparticles easily and economically.
Typically the co-precipitation route yields magneticnanoparticles with a polydisperse size distribution andresults in formation of cluster-like aggregates.
Representation of the micellar exchange process for the synthesis of gold nanoparticles in the
water/AOT/Isooctane system
Reverse micelle structure and relationship Dh vs w
6.61 0.298hD w
Reverse Micelles:
Using reverse micelles for nanostructure synthesis takesadvantage of the small size of the micellar water pools,which essentially act as nanoreactors that collide andexchange contents.
Reverse micelles consist of aqueous droplets that areseparated from the bulk organic phase by a surfactantlayer. The diameter (Dh) of these droplets greatlyinfluences the size of the resulting nanoparticles; wefound by Dynamic Light Scattering (DLS) measurements,that this value is dependent on the water-surfactantmolar ratio (w) selected for the systemwater/AOT/Isooctane :
Characterization
Fourier Transform Infrared spectroscopy:
(nm)
400 450 500 550 600 650 700
No
rmaliz
ed
ab
so
rptio
n0.0
0.2
0.4
0.6
0.8
1.0
1.2
5 nm
10 nm
15 nm
20 nm
30 nm40 nm
50 nm
60 nm
80 nm
100 nm
(nm)
300 400 500 600 700
No
rmaliz
ed
ab
so
rptio
n
0.5
1.0
1.5
2.0
2.5
w10-10 nm
w10-30 nm
w10-50 nm
w10-80 nm
w10-100 nm
a) Gold colloids absorption in
aqueous medium
b) Gold colloids absorption in
w10 system
Optical properties of gold nanoparticles:
Potential Applications of Nanoparticles
Synthesis of silver nanoparticles by using leaves extracts of cilantro (Coriandrumsativum)
Surface modification with cellulose
Evaluation of the antimicrobial action of silver nanoparticles modified with cellulose after contact with E. coli bacteria
Antimicrobial application of silver nanoparticles modified
with cellulose for the production of active food packs
Modified
nanoparticles
Synthesis of magnetic nanoparticles modified with TiO2 for photodegradation of phenol in
aqueous solutions
Local generation of heat in cancerous cells with AC magnetic field.
Biocompatiblemagneticnanoparticles insidecancer cells.
Application of an ACmagnetic field.Temperature rise to~46 °C
Destruction ofcancer cell
37 °C
~ 46 °C
