P R E S E N T E D B Y A M E R I C A S P H A R M A C E U T...

2009

CancerM E D I C I N E S I N D E V E L O P M E N T F O R

Report

P R E S E N T E D B Y A M E R I C A ’ S P H A R M A C E U T I C A L R E S E A R C H C O M P A N I E S

Few things cause patients more fear and uncertaintythan a cancer diagnosis. But today—because of asteady stream of new and improved medicines and

treatments—cancer increasingly can be managed and evenbeaten. President Obama has called for a cancer cure inour lifetime, patients and their families are looking for moreand better treatments, and America’s pharma ceuticalresearch and biotechnology companies are responding.

Pharmaceutical researchers are now working on861 medicines for cancer. Many are high-tech weaponsto fight the disease, while some involve innovativeresearch on using existing medicines in new ways.

The medicines in development—all in either clinicaltrials or under Food and Drug Administration review—include 122 for lung cancer, the leading cause of cancerdeath in the United States; 106 for breast cancer, which isexpected to strike more than 180,000 American womeneach year; 103 for prostate cancer, which is expected tokill more than 28,000 American men each year; and70 for colorectal cancer, the third most common cancerin both men and women in this country. Additionalmedicines target brain cancer, kidney cancer, leukemia,ovarian cancer, pancreatic cancer, skin cancer, andothers. In addition, companies are working on medicinesto improve the quality of life for cancer patients.

This commitment to patients and research is at the coreof the remarkable progress made in the past decade fightingcancer that has led to declines in both cancer cases andcancer deaths. Death rates for eight of the top 10 cancersremained level or declined during the 1990s, accordingto a Journal of the National Cancer Institute report.

America’s pharmaceutical research companies areworking on many new cutting edge approaches to fightcancer. They include:

• A medicine that inhibits production of a protein thatmay interfere with the effectiveness of chemotherapy.

• A drug that delivers a synthetic version of a substancederived from scorpions directly to brain tumor cells.

• A medicine designed to induce a powerful immuneresponse to melanoma.

• A potential first-line treatment (meaning it’s given topatients before any other treatment) and first-in-classmedicine designed to target specific cancer cells andkill them, then activate the patient’s general immunesystem to destroy any remaining cancer cells.

• One therapy in development uses new nanotech -nology that enhances the delivery of medicine tothe patient, overcoming obstacles in existingtreatments.

Despite progress, cancer remains the second leadingcause of death by disease in the United States, exceededonly by heart disease. In 2008, some 565,650 Americanswere expected to die of cancer—more than 1,500 peoplea day. The hundreds of new medicines to treat cancernow being developed by the pharma ceutical researchindustry demonstrate our commitment to meeting patientneeds. They are our best hope for stemming the toll ofcancer-related deaths.

Billy TauzinPresident and CEOPhRMA

More Than 800 Medicines and Vaccines in TestingOffer Hope in the Fight Against Cancer

MEDICINES IN DEVELOPMENT FOR CANCER*

*Some medicines are l is ted in more than one category.

Unspecified CancersOther Cancers

Cancer-Related ConditionsStomach Cancer

Solid TumorsSkin Cancer

SarcomaProstate Cancer

Pancreatic CancerOvarian Cancer

Multiple MyelomaLymphoma

Lung CancerLiver Cancer

LeukemiaKidney Cancer

Head/Neck CancerColorectal Cancer

Cervical CancerBreast CancerBrain Cancer

Bladder Cancer 2361

10613

7034

44129

35122

9952

6354

10327

67203

2751

5574

2 M E D I C I N E S I N D E V E L O P M E N T F O R Cancer 2009

Medicines in Development for CancerB L A D D E R C A N C E RProduct Name Sponsor Indication Development Status*

Advexin® Introgen Therapeutics (see also brain, breast, head/neck, Phase Icontusugene Austin, TX lung, ovarian, prostate, stomach) (512) 708-9310ladenovec

BC-819 BioCancell Therapeutics Phase IIJerusalem, Israel

belinostat Topo Target USA combination therapy Phase IIRockaway, NJ (see also colorectal, leukemia, (973) 895-6900

liver, lung, lymphoma, ovarian)

CDX-1307 Celldex Therapeutics (see also breast, colorectal, ovarian, Phase INeedham, MA pancreatic) (781) 433-0771

Celebrex® Pfizer (see also prostate) Phase IIIcelecoxib New York, NY (860) 732-5156

CG0070 Cell Genesys Phase ISouth San Francisco, CA (650) 266-3000Novartis Pharmaceuticals (888) 669-6682East Hanover, NJ

Chemophase™ Halozyme Therapeutics superficial bladder cancer Phase I/IIhyaluronidase San Diego, CA (858) 794-8889

EOquin® Spectrum Pharmaceuticals Phase IIIapaziquone Irvine, CA (949) 788-6700

Erbitux® Bristol-Myers Squibb (see also colorectal, head/neck, Phase IIcetuximab Princeton, NJ lung, prostate, stomach) (212) 546-4000

Eli Lilly (800) 545-5979Indianapolis, IN (212) 645-1405ImClone SystemsNew York, NY

Hexvix® GE Healthcare diagnostic imaging of application submittedhexyl Waukesha, WI bladder canceraminolevulinate

Iressa® AstraZeneca (see also brain) Phase IIgefitinib Wilmington, DE (800) 236-9933

larotaxel sanofi-aventis (see also pancreatic) Phase III(XRP9881) Bridgewater, NJ (800) 633-1810

Levulan® PD DUSA Pharmaceuticals (see also cervical, colorectal, lung, Phase I/IIaminolevulinic acid Wilmington, MA stomach) (978) 657-7500

MCC/HA Bioniche Life Sciences second-line therapy Phase IIIBelleville, Canada (800) 265-5464

OGX-427 Oncogenex (see also breast, lung, ovarian, Phase IPharmaceuticals prostate) (425) 686-1500Bothell, WA

* For more information about a specific medicine in this report, please call the telephone number listed.

3M E D I C I N E S I N D E V E L O P M E N T F O R Cancer 2009

B L A D D E R C A N C E RProduct Name Sponsor Indication Development Status

polyphenon E Polyphenon Pharma superficial bladder cancer Phase IINew York, NY (see also leukemia, prostate) (212) 661-0578

pralatrexate Allos Therapeutics (see also lung, lymphoma) Phase II(PDX) Westminster, CO (303) 426-6262

SCH-58500 Schering-Plough (see also head/neck, liver, Phase I(p53 gene therapy) Kenilworth, NJ lung, cancer-related) (908) 298-4000

SCH-721015 Schering-Plough Phase IKenilworth, NJ (908) 298-4000

Tarceva® Genentech neoadjuvant therapy Phase IIerlotinib South San Francisco, CA (see also brain, breast, colorectal, (650) 224-1000

OSI Pharmaceuticals head/neck, liver, lung, other) (800) 572-1932Melville, NY

Valstar® Indevus Pharmaceuticals application submittedvalrubicin Lexington, MA (781) 861-8444

VB-4845 Viventia Biotech (see also head/neck) Phase IIMississauga, Canada (905) 361-8686

vinflunine Pierre Fabre (see also breast) Phase IIPharmaceuticals (973) 898-1042Parsippany, NJ

B R A I N C A N C E RProduct Name Sponsor Indication Development Status

3F8 mAb United Therapeutics neuroblastoma, leptomeningeal Phase IISilver Spring, MD cancer (301) 608-9292

(see also other)

8H9 mAb United Therapeutics Phase ISilver Spring, MD (301) 608-9292

Advexin® Introgen Therapeutics glioblastoma Phase Icontusugene Austin, TX (see also bladder, breast, head/neck, (512) 708-9310ladenovec lung, ovarian, prostate, stomach)

AEE788 Novartis Pharmaceuticals glioblastoma multiforme Phase IEast Hanover, NJ (see also solid tumors) (888) 669-6682

AMG 102 Amgen glioma Phase IIThousand Oaks, CA (see also colorectal, kidney, lung, (805) 447-1000

stomach)

ANG-1005 AngioChem metastatic brain cancer, Phase IMontreal, Canada metastatic glioblastoma (514) 788-7800

Armala™ GlaxoSmithKline glioma Phase IIpazopanib Rsch. Triangle Park, NC (see also breast, cervical, kidney, (888) 825-5249

liver, lung, ovarian, sarcoma, other)



Avastin® Genentech glioblastoma application submittedbevacizumab South San Francisco, CA (see also colorectal, head/neck, (650) 225-1000

kidney, liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)-------------------------------------------------------------------------------------------metastatic brain cancer from Phase IINSCLC (650) 225-1000

Azedra™ Molecular Insight neuroblastoma in children Phase IIiodine-labeled Pharmaceuticals (see also other) (617) 492-5554metaiodobenzyl- Cambridge, MAguanidine

Azixa™ Myriad Pharmaceuticals glioblastoma, metastatic brain cancer Phase II(MPC-6827) Salt Lake City, UT (see also skin) (801) 584-3600

banoxantrone Transcept Pharmaceuticals glioblastoma Phase I/IIPt. Richmond, CA (510) 215-3500

berubicin Reata Pharmaceuticals brain metastases, recurrent primary Phase II(Orphan Drug) Dallas, TX brain cancer (972) 865-2200

--------------------------------------------------------------------------------------glioma Phase I

(972) 865-2200

BIBW 2992 Boehringer Ingelheim glioblastoma Phase I/IIPharmaceuticals (see also breast, head/neck, lung) (800) 243-0127Ridgefield, CT

BMS-844203 Bristol-Myers Squibb glioblastoma Phase II(VEGF inhibitor- Princeton, NJ (see also solid tumors) (212) 546-4000adnectin)

BSI-201 BiPar Sciences glioblastoma Phase I/IIBrisbane, CA (see also breast, ovarian, other) (650) 635-6050

CC-8490 Celgene glioblastoma Phase IISummit, NJ (908) 673-9000

CDX-110 Celldex Therapeutics newly diagnosed glioblastoma Phase II/III(Orphan Drug) Needham, MA (see also solid tumors) (781) 433-0771

Pfizer (860) 732-5156New York, NY

cilengitide EMD Serono newly diagnosed and recurrent Phase II(Orphan Drug) Rockland, MA glioblastoma (800) 283-8088

(see also lymphoma, prostate, solid tumors)

cintredekin NeoPharm glioblastoma Phase IIIbesudotox Lake Bluff, IL (847) 887-0800

Cotara™ Peregrine Pharmaceuticals glioblastoma Phase ImAb TNT-1 Tustin, CA (714) 508-6000(Orphan Drug)DCVax®-Brain® Northwest Biotherapeutics glioblastoma Phase IIbrain cancer Bothell, WA (425) 608-3000vaccine(Orphan Drug)



EMD 273063 EMD Serono neuroblastoma Phase IIRockland, MA (see also skin) (800) 283-8088

enzastaurin Eli Lilly glioblastoma (combination therapy) Phase II(LY317615) Indianapolis, IN (see also breast, colorectal, (800) 545-5979

lymphoma, multiple myeloma, ovarian, prostate)

G 207 MediGene glioma Phase I(Orphan Drug) San Diego, CA (858) 586-2240

gimatecan Novartis Pharmaceuticals glioma Phase I/II(Orphan Drug) East Hanover, NJ (see also leukemia) (888) 669-6682

GliAtak™ Advantagene Phase I/IIgene therapy Boston, MA (617) 916-5445

San Diego, CA (760) 943-8981

ICT-107 ImmunoCellular glioblastoma Phase I(cancer vaccine) Therapeutics (818) 992-2907

Woodland Hills, CA

Iressa® AstraZeneca glioblastoma Phase IIgefitinib Wilmington, DE (see also bladder) (800) 236-9933

Karenitecin® BioNumerik (see also lung, ovarian, skin) Phase II completedcositecan Pharmaceuticals (210) 614-1701

San Antonio, TX

KRX-0402 Keryx Biopharmaceuticals brain cancer, glioblastoma Phase IINew York, NY (combination therapy), (212) 531-5965

glioma (combination therapy) (see also colorectal, kidney, multiple myeloma, sarcoma)

laromustine Vion Pharmaceuticals glioma (combination therapy) Phase II(VNP 40101M) New Haven, CT (see also leukemia) (203) 498-4210

Lucanix® NovaRx glioma Phase Ibelagenpumatucel-L San Diego, CA (see also lung) (858) 552-8600

lucanthone Spectrum Pharmaceuticals glioma (combination therapy) Phase IIrvine, CA (949) 788-6700

MLN8237 Millennium neuroblastoma Phase I/IIPharmaceuticals (see also leukemia, lymphoma, (800) 390-5663Cambridge, MA solid tumors)

Neuradiab™ Bradmer Pharmaceuticals glioblastoma Phase IIIanti-tenascin Louisville, KY (502) 657-6038mAb 81C6-I-131(Orphan Drug)OncoGel® Protherics glioblastoma Phase I/II

Brentwood, TN (see also pancreatic, stomach) (615) 327-1027

Oncophage® Antigenics glioma Phase IIvitespan New York, NY (see also colorectal, kidney, (866) 805-8994

pancreatic, skin, stomach)

panobinostat Novartis Pharmaceuticals glioma Phase I/IIEast Hanover, NJ (see also breast, leukemia, (888) 669-6682

lymphoma, prostate)



patupilone Novartis Pharmaceuticals (see also breast, colorectal, liver, Phase II(EPO906) East Hanover, NJ lung, ovarian) (888) 669-6682

perifosine AEterna Zentaris glioma Phase IIMontreal, Canada (see also head/neck, kidney, (212) 531-5965Keryx Biopharmaceuticals lymphoma, multiple myeloma, New York, NY ovarian, sarcoma)

PRX-321 Protox Therapeutics glioblastoma Phase II(Orphan Drug) Vancouver, Canada (see also solid tumors) (604) 688-0199

Reolysin® Oncolytics Biotech glioma Phase I/IIreovirus Calgary, Canada (see also head/neck, lung, sarcoma, (403) 670-7377

skin)

sagopilone Bayer HealthCare (see also breast, ovarian, prostate) Phase IIPharmaceuticals (888) 842-2937Wayne, NJ

SBG Biotec Pharmacon neuroblastoma (pediatric) Phase I/IITromso, Norway (combination therapy) www.biotec.no

systemic hedgehog Genentech (see also colorectal, ovarian, skin) Phase Iantagonist South San Francisco, CA (650) 224-1000

talampanel Teva Pharmaceuticals newly diagnosed glioblastoma Phase IINorth Wales, PA (215) 591-3000

tandutinib Millennium glioma Phase II(MLN0518) Pharmaceuticals (see also prostate) (800) 390-5663

Cambridge, MA --------------------------------------------------------------------------------------gliobastoma Phase I/II

(800) 390-5663

Tarceva® Genentech glioblastoma Phase IIerlotinib South San Francisco, CA (see also bladder, breast, colorectal, (650) 225-1000(Orphan Drug) OSI Pharmaceuticals head/neck, liver, lung, other) (800) 572-1932

Melville, NY

terameprocol Erimos Pharmaceuticals glioma Phase I/IIHouston, TX (see also cervical, head/neck) (713) 541-2000

TheraCIM™ YM Biosciences glioma (pediatric) Phase IInimotuzumab Wayne, PA (see also breast, prostate, stomach) (610) 560-0600(Orphan Drug)TM-601 TransMolecular recurrent high-grade glioma Phase I(Orphan Drug) Cambridge, MA (617) 995-3050

TM-601-I-131 TransMolecular glioma (intracranial) Phase II(Orphan Drug) Cambridge, MA (see also skin) (617) 995-3050

--------------------------------------------------------------------------------------glioma (intravenous) Phase I/II

(617) 995-3050

Trisenox® Cephalon glioma Phase Iarsenic trioxide Frazer, PA (see also leukemia, multiple myeloma) (610) 344-0200

Tykerb® GlaxoSmithKline brain metastases from breast cancer Phase IIIlapatinib Rsch. Triangle Park, NC (see also head/neck, stomach) (888) 825-5249



VP101 Access Pharmaceuticals glioblastoma Phase II(Orphan Drug) Dallas, TX (see also colorectal, leukemia, (214) 905-5100

prostate)

Xcytrin® Pharmacyclics brain metastases from non-small-cell application submittedmotexafin Sunnyvale, CA lung cancer (408) 774-0330gadolinium (see also kidney, leukemia, lung,

lymphoma) --------------------------------------------------------------------------------------glioma (combination therapy) Phase II

(408) 774-0330--------------------------------------------------------------------------------------glioblastoma (combination therapy) Phase I

(408) 774-0330

Xerecept® Celtic Pharma peritumoral brain edema Phase IIIcorticorelin Hamilton, Bermuda (441) 299-7440(Orphan Drug)XL-184 Bristol-Myers Squibb glioblastoma in clinical trials

Princeton, NJ (see also other) (212) 546-4000ExelixisSouth San Francisco, CA

XL-765 Exelixis glioma Phase ISouth San Francisco, CA (see also solid tumors) (650) 837-7000

Zactima® AstraZeneca glioma Phase Ivandetanib Wilmington, DE (see also breast, lung, other) (800) 236-9933

Zolinza® Merck glioblastoma Phase IIvorinostat Whitehouse Station, NJ (see also breast, colorectal, (800) 672-6372

kidney, leukemia, lung, lymphoma, multiple myeloma)

B R E A S T C A N C E RProduct Name Sponsor Indication Development Status

ABI-008 Abraxis BioScience metastatic breast cancer Phase I/IILos Angeles, CA (see also prostate) (310) 883-1300

ABT-751 Abbott Laboratories (see also colorectal, kidney, lung) Phase IIAbbott Park, IL (847) 937-6100

ABT-869 Abbott Laboratories combination therapy Phase IIAbbott Park, IL (see also kidney, liver, lung) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

aderbasib Incyte combination therapy Phase II(INCB7839) Wilmington, DE (302) 498-6700

Advexin® Introgen Therapeutics combination therapy Phase IIcontusugene Austin, TX (see also bladder, brain, head/neck, (512) 708-9310ladenovec lung, ovarian, prostate, stomach)



AE-37 Antigen Express (see also ovarian) Phase IIWorcester, MA (508) 852-8783

AG-14699 Pfizer (see also ovarian) Phase IINew York, NY (860) 732-5156

Alimta® Eli Lilly (see also head/neck, lung, ovarian) Phase IIpemetrexed Indianapolis, IN (800) 545-5979

AMG 386 Amgen (see also kidney, ovarian, Phase IIThousand Oaks, CA stomach, other) (805) 447-1000

AMG 479 Amgen (see also colorectal, lung, Phase IIThousand Oaks, CA pancreatic, sarcoma) (805) 447-1000

Amplimexon® AmpliMed (see also lung, multiple myeloma, Phase Iimexon Tucson, AZ pancreatic, prostate, skin) (520) 529-1000

anti-CD3 TransTarget metastatic breast cancer Phase Iactivated T-cells Hillsborough, CA

anti-MUC1 mAb Paladin Labs (see also multiple myeloma, Phase I completedSt. Laurent, Canada pancreatic) (888) 376-7830

anti-PEM mAb Access Pharmaceuticals Phase I/IIDallas, TX (214) 905-5100

Armala™ GlaxoSmithKline combination therapy Phase IIIpazopanib Rsch. Triangle Park, NC (see also brain, cervical, kidney, (888) 825-5249


Aromasin® Pfizer breast cancer prevention Phase IIIexemestane New York, NY (860) 732-5156

ARRY-543 Array BioPharma combination therapy Phase I/IIBoulder, CO (303) 381-6600

arzoxifene Eli Lilly invasive breast cancer risk reduction Phase IIIIndianapolis, IN (800) 545-5979

AS-1402 Antisoma Phase IICambridge, MA (617) 225-0522

AVE1642 sanofi-aventis hormonal-sensitive breast cancer Phase II(anti-IGF-1R mAb) Bridgewater, NJ (800) 633-1810

AZD2281 AstraZeneca monotherapy Phase IIWilmington, DE (see also ovarian) (800) 236-9933

--------------------------------------------------------------------------------------combination therapy Phase I/II

(800) 236-9933

AZD4992 AstraZeneca Phase IWilmington, DE (800) 236-9933

BIBW 2992 Boehringer Ingelheim second-line therapy Phase IIPharmaceuticals (see also brain, head/neck, lung) (800) 243-0127Ridgefield, CT

bleomycin Inovio Biomedical (see also head/neck) Phase I(electrical San Diego, CA (858) 597-6006pulse delivery)

bosutinib Wyeth Pharmaceuticals (see also leukemia, solid tumors) Phase IICollegeville, PA (800) 934-5556



breast cancer Quantum Immunologics Phase I/IIvaccine Tampa, FL (866) 213-4594

BSI-201 BiPar Sciences (see also brain, ovarian, other) Phase IIBrisbane, CA (650) 635-6050

BTSCAN Molecular Targeting diagnosis of breast cancer Phase ITechnologies (610) 738-7938West Chester, PA

BZL-101 Bionovo Phase IIEmeryville, CA (510) 601-2000

cancer vaccine MabVax Therapeutics (see also sarcoma) Phase ISan Diego, CA (858) 259-9405

Capoxigem® Tragara Pharmaceuticals combination therapy Phase IIapricoxib San Diego, CA (see also lung, pancreatic) (858) 350-6900

CDX-1307 Celldex Therapeutics (see also bladder, colorectal, Phase INeedham, MA ovarian, pancreatic) (781) 433-0771

cediranib AstraZeneca (see also kidney, leukemia) Phase IIWilmington, DE (800) 236-9933

CNF-2024 Biogen Idec (see also leukemia, solid tumors, Phase ICambridge, MA stomach) (617) 679-2000

CP-751871 Pfizer combination therapy Phase IINew York, NY (see also colorectal, lung, multiple (860) 732-5156

myeloma, prostate, sarcoma)

CR011-vcMMAE CurGen (see also skin) Phase IIBranford, CT (888) 436-6642

deforolimus ARIAD Pharmaceuticals combination therapy Phase II(MK-8669) Cambridge, MA (see also lung, prostate, sarcoma, (617) 494-0400

Merck other) (800) 672-6372Whitehouse Station, NJ

Doxil® Ortho Biotech combination therapy application submitteddoxorubicin Bridgewater, NJ (908) 541-4000liposomeinjection

doxorubicin Sopherion Therapeutics combination therapy Phase IIIliposomal Princeton, NJ (609) 986-2021

enzastaurin Eli Lilly combination therapy Phase II(LY317615) Indianapolis, IN (see also brain, colorectal, (800) 545-5979

lymphoma, multiple myeloma, ovarian, prostate)

eribulin mesylate Eisai metastatic breast cancer Phase III(E7389) Woodcliff Lake, NJ (see also head/neck, lung, ovarian, (888) 422-4743

prostate, sarcoma, solid tumors)--------------------------------------------------------------------------------------advanced breast cancer Phase II

(888) 422-4743

Genasense® Genta (see also leukemia, lung, lymphoma, Phase II completedoblimersen Berkeley Heights, NJ skin, solid tumors) (908) 286-9800



glufosfamide Threshold Pharmaceuticals (see also lung, pancreatic, Phase IIRedwood City, CA sarcoma) (650) 474-8200

GRN-163L Geron combination therapy Phase I/IIMenlo Park, CA (see also leukemia, lung, (650) 473-7700

multiple myeloma)

HER2-antigen- Genentech Phase IIspecific cancer South San Francisco, CA (650) 224-1000immunotherapeutic

HER2/neu GlaxoSmithKline Phase I/IIpeptide vaccine Rsch. Triangle Park, NC (888) 825-5249

Hycamtin® GlaxoSmithKline (see also colorectal, head/neck, Phase IItopotecan Rsch. Triangle Park, NC kidney, leukemia, lung, lymphoma, (888) 825-5249

multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

IMC-1121B Eli Lilly (see also colorectal, kidney, liver, Phase IIIIndianapolis, IN lung, ovarian, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also colorectal, head/neck, Phase IIIndianapolis, IN liver, lung, pancreatic, prostate, (800) 545-5979ImClone Systems sarcoma, solid tumors) (212) 645-1045New York, NY

IMT-1012 ImmunoVaccine (see also ovarian) Phase ITechnologies (902) 492-1819Halifax, Canada

INGN 225 Introgen Therapeutics (see also lung) Phase I/II(p53 vaccine) Austin, TX (512) 708-9310

ispinesib CytoKinetics (see also colorectal, kidney, Phase IISouth San Francisco, CA leukemia) (650) 624-3000

Ixempra™ Bristol-Myers Squibb early breast cancer in clinical trialsixabepilone Princeton, NJ (see also lung, pancreatic, prostate) (212) 546-4000

lapuleucel-T Dendreon (see also colorectal, ovarian) Phase I completedSeattle, WA (206) 256-4545

LEP-ETU NeoPharm Phase IILake Bluff, IL (847) 887-0800

LOR-2040 Lorus Therapeutics metastatic breast cancer Phase IIToronto, Canada (see also colorectal, kidney, (416) 798-1200

leukemia)

Lymphoseek™ Neoprobe diagnosis of breast cancer Phase IIIDublin, OH (see also skin) (800) 793-0079

milataxel Taxolog (see also colorectal, lung) Phase IIFairfield, NJ (877) 829-6564

MK-0646 Merck (see also lung, pancreatic, other) Phase IWhitehouse Station, NJ (800) 672-6372



MK-0752 Merck (see also leukemia) Phase IWhitehouse Station, NJ (800) 672-6372

MKC 1 EntreMed metastatic breast cancer Phase II completedRockville, MD (see also leukemia, lung, pancreatic) (240) 864-2600

motesanib Amgen combination therapy Phase IIThousand Oaks, CA (see also colorectal, lung, other) (805) 447-1000Millennium (800) 390-5663PharmaceuticalsCambridge, MA

NBI-42902 Neurocrine Biosciences (see also prostate, other) Phase ISan Diego, CA (858) 617-7600

neratinib Wyeth Pharmaceuticals monotherapy Phase III(HKI272) Collegeville, PA (see also lung) (800) 934-5556


(800) 934-5556

NeuVax™ Apthera (see also prostate) Phase IIE75 cancer Scottsdale, AZ (480) 882-8841vaccine

Nexavar® Bayer HealthCare combination therapy Phase IIsorafenib Pharmaceuticals (see also lung, skin) (888) 842-2937

Wayne, NJ (510) 597-6500Onyx PharmaceuticalsEmeryville, CA

NOV-002 Novelos Therapeutics early-stage breast cancer Phase IINewton, MA (see also lung, ovarian) (617) 244-1616

OBP-301 Oncolys Biopharma (see also head/neck, lung) Phase ITokyo, Japan www.oncolys.com

OGX-427 Oncogenex (see also bladder, lung, ovarian, Phase IPharmaceuticals prostate) (425) 686-1500Bothell, WA

OPT-22 Optimer Pharmaceuticals Phase ISan Diego, CA (858) 909-0736

panobinostat Novartis Pharmaceuticals (see also brain, leukemia, Phase I/IIEast Hanover, NJ lymphoma, prostate) (888) 669-6682

patupilone Novartis Pharmaceuticals (see also brain, colorectal, liver, Phase II(EPO906) East Hanover, NJ lung, ovarian) (888) 669-6682

PD-332991 Pfizer combination therapy, Phase I/IINew York, NY first-line therapy (860) 732-5156

(see also lymphoma, multiple myeloma)

pertuzumab Genentech first-line therapy, metastatic Phase IIISouth San Francisco, CA breast cancer (650) 224-1000

(see also ovarian)

PTC-299 PTC Therapeutics (see also skin) Phase I/IISouth Plainfield, NJ (908) 222-7000



PX-1032 BN ImmunoTherapeutics Phase I/II(HER2 breast Mountain View, CA (650) 681-4660cancer vaccine) Pharmexa

Horsholm, Denmark

Quinamed® ChemGenex (see also ovarian, prostate) Phase IIamonafide Pharmaceuticals (650) 474-9800

Menlo Park, CA

R1507 Roche combination therapy Phase IINutley, NJ (see also lung, lymphoma, sarcoma) (973) 235-5000

retaspimycin Infinity Pharmaceuticals (see also lung, stomach) Phase II(IPI 504) Cambridge, MA (617) 453-1000

Reximmune-C™ Epeius Biotechnologies Phase I/IISan Marino, CA (626) 441-6695

Rexin-G™ Epeius Biotechnologies recurrent, refractory metastatic Phase I/IItumor-targeted San Marino, CA breast cancer (626) 441-6695gene therapy (see also pancreatic, sarcoma)

sagopilone Bayer HealthCare (see also brain, ovarian, prostate) Phase IIPharmaceuticals (888) 842-2937Wayne, NJ

Sarasar™ Schering-Plough (see also leukemia, pancreatic) Phase IIlonafarnib Kenilworth, NJ (908) 298-4000

satraplatin Spectrum Pharmaceuticals metastatic breast cancer, Phase II completedIrvine, CA second-line therapy (949) 788-6700

(see also lung, prostate)

SCH-727965 Schering-Plough (see also leukemia, lung) Phase IIKenilworth, NJ (908) 298-4000

SF1 SonneMed advanced breast cancer Phase I/IIBoston, MA

SNDX-275 Syndax Pharmaceuticals (see also lung) Phase IIWaltham, MA (781) 839-7301

SU-14813 Pfizer Phase IINew York, NY (860) 732-5156

Sutent® Pfizer (see also colorectal, liver, lung, Phase IIIsunitinib New York, NY pancreatic, prostate, sarcoma, (860) 732-5156

stomach)

TamoGel™ ASCEND Therapeutics Phase IIafimoxifene Herndon, VA (703) 471-4744

Tarceva® Genentech (see also bladder, brain, colorectal, Phase IIerlotinib South San Francisco, CA head/neck, liver, lung, other) (650) 224-1000

OSI Pharmaceuticals (800) 572-1932Melville, NY

TAS-108 Taiho Pharma USA Phase IIPrinceton, NJ (609) 750-5300

Telcyta™ Telik (see also colorectal, lung, ovarian) Phase II completedcanfosfamide Palo Alto, CA (650) 845-7700



tesmilifene YM BioSciences (see also prostate) Phase IIIWayne, PA (610) 560-0600

TheraCIM™ YM Biosciences adjunctive treatment Phase Inimotuzumab Wayne, PA (see also brain, prostate, stomach) (610) 560-0600

Thermodox™ Celsion locally recurrent breast cancer Phase I/IILTSDEL Columbia, MD (see also liver) (410) 290-5390

trastuzumab-DM1 Genentech metastatic breast cancer Phase IIISouth San Francisco, CA (second-line therapy) (650) 225-1000ImmunoGen (781) 895-0600Waltham, MA --------------------------------------------------------------------------------------

metastatic breast cancer Phase II(first-line therapy, third-line therapy) (650) 225-1000

(781) 895-0600

Trelstar® Watson Pharmaceuticals Phase IIItriptorelin Corona, CA (951) 493-5300

tremelimumab Pfizer (see also colorectal, kidney, lung, Phase INew York, NY prostate, skin) (860) 732-5156

trilostane Genzyme (see also prostate) in clinical trialsCambridge, MA (617) 252-7500

vinflunine Pierre Fabre advanced breast cancer Phase IIIPharmaceuticals (see also bladder) (973) 898-1042Parsippany, NJ

WX-671 Wilex Phase IIMunich, Germany www.wilex.com

Yondelis® Johnson & Johnson (see also ovarian, prostate, Phase IItrabectedin Pharmaceutical Research sarcoma, other) (800) 817-5286

& DevelopmentRaritan, NJ

Zactima® AstraZeneca (see also brain, lung, other) Phase IIvandetanib Wilmington, DE (800) 236-9933

Zolinza® Merck (see also brain, colorectal, kidney, Phase IIvorinostat Whitehouse Station, NJ leukemia, lung, lymphoma, (800) 672-6372

multiple myeloma)

ZYC300 Eisai (see also colorectal, kidney, Phase IWoodcliff Lake, NJ ovarian, prostate) (888) 422-4743

C E R V I C A L C A N C E RProduct Name Sponsor Indication Development Status

A-007 Tigris Pharmaceuticals cervical intraepithelial neoplasia Phase II completedBonita Springs, FL (see also colorectal) (239) 444-5400

Armala™ GlaxoSmithKline (see also brain, breast, kidney, Phase IIpazopanib Rsch. Triangle Park, NC liver, lung, ovarian, sarcoma, other) (888) 825-5249

Camptosar® Pfizer (see also lung, pancreatic, prostate) application submittedirinotecan New York, NY (860) 732-5156


C E R V I C A L C A N C E RProduct Name Sponsor Indication Development Status

HspE7 Nventa Biopharmaceuticals cervical intraepithelial neoplasia Phase I completed(verpasep caltespen) San Diego, CA (858) 202-4900

Levulan® PD DUSA Pharmaceuticals cervical intraepithelial neoplasia Phase IIaminolevulinic acid Wilmington, DE (see also bladder, colorectal, lung, (978) 657-7500

stomach)

Multikine® CEL-SCI cervical cancer, cervical dysplasia Phase I/II completedleukocyte interleukin Vienna, VA (see also head/neck) (703) 506-9460

PV701 Wellstat Biologics (see also colorectal) Phase IIGaithersburg, MD (240) 631-2500

R3484 Roche cervical intraepithelial neoplasia Phase II(MVA-HPV-IL2 Nutley, NJ (973) 235-5000vaccine)

TAK-851 Millennium cervical dysplasia Phase IIPharmaceuticals (800) 390-5663Cambridge, MA

terameprocol Erimos Pharmaceuticals cervical intraepithelial neoplasia Phase IIHouston, TX (see also brain, head/neck) (713) 541-2000

tirapazamine SRI International Phase IIIMenlo Park, CA (650) 859-2000

V503 Merck cervical cancer prevention Phase IIIWhitehouse Station, NJ (see also other) (800) 672-6372

V505 Merck Phase IIIWhitehouse Station, NJ (800) 672-6372

C O L O R E C T A L C A N C E RProduct Name Sponsor Indication Development Status

1018 ISS Dynavax Technologies (see also lymphoma) Phase IBerkeley, CA (510) 848-5100

A-007 Tigris Pharmaceuticals anal intraepithelial neoplasia Phase I/IIBonita Springs, FL (see also cervical) (239) 444-5400

ABT-751 Abbott Laboratories (see also breast, kidney, lung) Phase IIAbbott Park, IL (847) 937-6100

aflibercept sanofi-aventis second-line metastatic Phase III(VEGF-trap) Bridgewater, NJ colorectal cancer (800) 633-1610

Regeneron Pharmaceuticals (combination therapy) (914) 345-7400Tarrytown, NY (see also lung, pancreatic,

prostate, other)

AMG 102 Amgen (see also brain, kidney, lung, Phase I/IIThousand Oaks, CA stomach) (805) 447-1000

AMG 479 Amgen (see also breast, lung, pancreatic, Phase IIThousand Oaks, CA sarcoma) (805) 447-1000



AMG 951 Amgen (see also lymphoma) Phase I(rhApo2L/TRAIL) Thousand Oaks, CA (805) 447-1000

Genentech (650) 225-1000South San Francisco, CA

apomab Genentech (see also lung, lymphoma) Phase ISouth San Francisco, CA (650) 225-1000

AR-726 Antigenics (see also lymphoma) Phase IINew York, NY (212) 994-8200

Avastin® Genentech adjuvant treatment Phase IIIbevacizumab South San Francisco, CA (see also brain, head/neck, kidney, (650) 225-1000

liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

AVX701 AlphaVax colorectal cancer prevention Phase I/IIRsch. Triangle Park, NC (919) 595-0400

axitinib Pfizer combination first-line therapy Phase IINew York, NY (see also kidney, lung, solid tumors, (860) 732-5156

other)--------------------------------------------------------------------------------------metastatic colorectal cancer Phase II(combination second-line therapy) (860) 732-5156

belinostat TopoTarget USA (see also bladder, leukemia, Phase IRockaway, NJ liver, lung, lymphoma, ovarian) (973) 895-6900

brivanib Bristol-Myers Squibb metastatic colorectal cancer Phase III(VEGFR/FGFR Princeton, NJ (combination with cetuximab) (212) 546-4000kinase inhibitor) (see also liver)

CDX-1307 Celldex Therapeutics (see also bladder, breast, ovarian, Phase INeedham, MA pancreatic) (781) 433-0771

conatumumab Amgen (see also lung, pancreatic, sarcoma) Phase IIThousand Oaks, CA (805) 447-1000

CP-751871 Pfizer (see also breast, lung, multiple Phase IINew York, NY myeloma, prostate, sarcoma) (860) 732-5156

CPX-1 Celator Pharmaceuticals Phase IIPrinceton, NJ (609) 243-0123

Davanat™ Pro-Pharmaceuticals (see also solid tumors) Phase IIgalactomannan C Newton, MA (617) 559-0033

denenicokin ZymoGenetics combination therapy Phase I(IL-21) Seattle, WA (see also kidney, lymphoma, (206) 442-6600

ovarian, skin)

edotecarin Pfizer Phase IIINew York, NY (860) 732-5156

enzastaurin Eli Lilly combination therapy Phase II(LY317615) Indianapolis, IN (see also brain, breast, lymphoma, (800) 545-5979

multiple myeloma, ovarian, prostate)



Erbitux® Bristol-Myers Squibb adjuvant, first-line, second-line Phase IIIcetuximab Princeton, NJ colorectal cancer (212) 546-4000

Eli Lilly (see also bladder, head/neck, lung, (800) 545-5979Indianapolis, IN prostate, stomach) (212) 645-1405ImClone Systems --------------------------------------------------------------------------------------New York, NY rectal cancer Phase II

(212) 546-4000(800) 545-5979(212) 645-1405

Fusilev™ Spectrum Pharmaceuticals (see also sarcoma) application submittedlevoleucovorin Irvine, CA (949) 788-6700for injection

Herceptin® Genentech (see also ovarian, pancreatic, Phase IItrastuzumab South San Francisco, CA prostate, stomach, other) (650) 225-1000

huA33 Life Science Phase IPharmaceuticals (203) 422-6500Greenwich, CT

Hycamtin® GlaxoSmithKline (see also breast, head/neck, kidney, Phase IItopotecan Rsch. Triangle Park, NC leukemia, lung, lymphoma, multiple (888) 825-5249

myeloma, ovarian, pancreatic, prostate, stomach, other)

IMC-1121B Eli Lilly (see also breast, kidney, liver, lung, Phase IIIndianapolis, IN ovarian, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also breast, head/neck, liver, Phase IIIndianapolis, IN lung, pancreatic, prostate, sarcoma, (800) 545-5979ImClone Systems solid tumors) (212) 645-1405New York, NY

IMO-2055 Idera Pharmaceuticals combination therapy Phase ICambridge, MA (see also kidney, lung) (617) 679-5500

ispinesib CytoKinetics (see also breast, kidney, leukemia) Phase IISouth San Francisco, CA (650) 624-3000

KRN-330 Kirin Pharma USA Phase ILa Jolla, CA (858) 952-7000

KRX-0402 Keryx Biopharmaceuticals (see also brain, kidney, Phase INew York, NY multiple myeloma, sarcoma) (212) 531-5965

lapuleucel-T Dendreon (see also breast, ovarian) Phase I completedSeattle, WA (206) 256-4545

LE-SN38 NeoPharm second-line therapy Phase IILake Bluff, IL (847) 887-0800

Levulan® PD DUSA Pharmaceuticals (see also bladder, cervical, lung, in clinical trialsaminolevulinic acid Wilmington, MA stomach) (978) 657-7500

Litx™ Light Sciences Oncology metastatic colorectal cancer Phase IIItalaporfin Bellevue, WA (425) 957-8900

LOR-2040 Lorus Therapeutics metastatic colorectal cancer Phase IIToronto, Canada (see also breast, kidney, leukemia) (416) 798-1200



milataxel Taxolog (see also breast, lung) Phase IIFairfield, NJ (877) 829-6564

motesanib Amgen metastatic colorectal cancer Phase IThousand Oaks, CA (combination therapy) (805) 447-1000Millennium (see also breast, lung, other) (800) 390-5663PharmaceuticalsCambridge, MA

NKTR-102 Nektar Therapeutics combination, second-line therapy Phase IISan Carlos, CA (see also ovarian) (650) 631-3100

Oncophage® Antigenics (see also brain, kidney, pancreatic, Phase IIvitespen New York, NY skin, stomach) (866) 805-8994

OncoVAX® Vaccinogen stage III colorectal cancer Phase IIcancer vaccine Frederick, MD (combination therapy) (301) 668-8400

(see also kidney, skin)--------------------------------------------------------------------------------------colorectal cancer Phase I/II

(301) 668-8400

patupilone Novartis Pharmaceuticals (see also brain, breast, liver, lung, Phase I/II(EPO906) East Hanover, NJ ovarian) (888) 669-6682

pelitinib Wyeth Pharmaceuticals second-line therapy Phase II(EKB569) Collegeville, PA (see also lung) (800) 934-5556

picoplatin Poniard Pharmaceuticals (see also lung) Phase IISeattle, WA (206) 281-7001

PN401 Wellstat Therapeutics (see also pancreatic, stomach) Phase IGaithersburg, MD (240) 631-2500

PV701 Wellstat Biologics (see also cervical) Phase IIGaithersburg, MD (240) 631-2500

RIGScan® CR49 Neoprobe diagnosis of colorectal cancer Phase IIIradiodiagnostic Dublin, OH (800) 793-0079agent

RM1812 Royalmount Pharmaceuticals Phase IMontreal, Canada (514) 340-7849

robatumumab Schering-Plough (see also sarcoma) Phase IIKenilworth, NJ (908) 298-4000

sibrotuzumab Life Science (see also head/neck, lung) Phase IIPharmaceuticals (203) 422-6500Greenwich, CT

Sutent® Pfizer (see also breast, liver, lung, Phase IIsunitinib New York, NY pancreatic, prostate, sarcoma, (860) 732-5156

stomach)

systemic hedgehog Genentech first-line therapy Phase IIantagonist South San Francisco, CA (see also brain, ovarian, skin) (650) 224-1000

Tarceva® Genentech combination therapy Phase IIerlotinib South San Francisco, CA (see also bladder, brain, breast, (650) 224-1000

OSI Pharmaceuticals head/neck, liver, lung, other) (800) 572-1932Melville, NY




tegafur/uracil EMD Serono (see also head/neck) Phase IIIcombination Rockland, MA (800) 283-8088

Telcyta™ Telik (see also breast, lung, ovarian) Phase II completedcanfosfamide Palo Alto, CA (650) 845-7700

tesetaxel Genta second-line therapy Phase IIBerkeley Heights, NJ (see also stomach) (908) 286-9800

tetrandrine Millenia Hope Phase IIIMontreal, Canada (514) 846-5757

Thymitaq® YM BioSciences USA (see also head/neck, liver, lung, Phase IInolatrexed Wayne, PA pancreatic, prostate) (610) 560-0600

TNFerade™ GenVec (see also head/neck, pancreatic, Phase IIGaithersburg, MD skin, stomach) (240) 632-0740

Torisel™ Wyeth Pharmaceuticals (see also kidney, lung, lymphoma, Phase IItemsirolimus Collegeville, PA multiple myeloma, prostate) (800) 934-5556

tremelimumab Pfizer (see also breast, kidney, lung, Phase IINew York, NY prostate, skin) (860) 732-5156

tucotuzumab EMD Serono (see also lung, ovarian, prostate) Phase IIcelmoleukin Rockland, MA (800) 283-8088

Urso Forte™ Axcan Pharma (see also cancer-related) Phase IIursodeoxycholic Birmingham, AL (205) 991-8085acid

VP101 Access Pharmaceuticals (see also brain, leukemia, prostate) Phase IIDallas, TX (214) 905-5100

Xeloda® Roche first-line metastatic colorectal cancer, application submittedcapecitabine Nutley, NJ second-line metastatic colorectal (973) 235-5000

cancer(see also stomach)

Zolinza® Merck (see also brain, breast, kidney, Phase Ivorinostat Whitehouse Station, NJ leukemia, lung, lymphoma, (800) 672-6372

multiple myeloma)

ZYC300 Eisai colon cancer Phase IWoodcliff Lake, NJ (see also breast, kidney, ovarian, (888) 422-4743

prostate)

H E A D / N E C K C A N C E RProduct Name Sponsor Indication Development Status

Abraxane™ Abraxis BioScience (see also lung, ovarian, pancreatic, Phase I/IIalbumin-bound Los Angeles, CA prostate, skin) (310) 883-1300paclitaxel



Advexin® Introgen Therapeutics (see also bladder, brain, breast, Phase III completedcontusugene Austin, TX lung, ovarian, prostate, stomach) (512) 708-9310ladenovec(Orphan Drug)Alimta® Eli Lilly (see also breast, lung, ovarian) Phase IIIpemetrexed Indianapolis, IN (800) 545-5979

AP-5346 Access Pharmaceuticals Phase IIDallas, TX (214) 905-5100

ARQ-501 ArQule (see also pancreatic, solid tumors, Phase II(beta lapachone) Woburn, MA other) (781) 994-0300

Avastin® Genentech combination therapy Phase IIIbevacizumab South San Francisco, CA (see also brain, colorectal, kidney, (650) 225-1000

liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

BIBW 2992 Boehringer Ingelheim second-line therapy Phase IIPharmaceuticals (see also brain, breast, lung) (800) 243-0127Ridgefield, CT

bleomycin Inovio Biomedical (see also breast) Phase III(electrical pulse San Diego, CA (858) 597-6006delivery)

Erbitux® Bristol-Myers Squibb first-line application submittedcetuximab Princeton, NJ (see also bladder, colorectal, lung, (212) 546-4000

Eli Lilly prostate, stomach) (800) 545-5979Indianapolis, IN (212) 645-1405ImClone SystemsNew York, NY

eribulin mesylate Eisai (see also breast, lung, ovarian, Phase II(E7389) Woodcliff Lake, NJ prostate, sarcoma, solid tumors) (888) 422-4743

Gemzar® Eli Lilly (see also lung, lymphoma, sarcoma) Phase Igemcitabine Indianapolis, IN (800) 545-5979

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IItopotecan Rsch. Triangle Park, NC kidney, leukemia, lung, lymphoma, (888) 825-5249


IMC-A12 Eli Lilly (see also breast, colorectal, liver, Phase IIIndianapolis, IN lung, pancreatic, prostate, sarcoma, (800) 545-5979ImClone Systems solid tumors) (212) 645-1405New York, NY

ING 234 Colgate-Palmolive orofacial cancer (prevention) Phase II(mouthwash) New York, NY (512) 708-9310

Introgen TherapeuticsAustin, TX

INGN 241 Introgen Therapeutics combination therapy Phase III(mda-7) Austin, TX (see also skin) (512) 708-9310

IRX-2 IRX Therapeutics Phase IINew York, NY (212) 582-1199



Multikine® CEL-SCI (see also cervical) Phase IIleukocyte Vienna, VA (703) 506-9460interleukin

OBP-301 Oncolys Biopharma (see also breast, lung) Phase ITokyo, Japan www.oncolys.com

perifosine AEterna Zentaris (see also brain, kidney, lymphoma, Phase IIMontreal, Canada multiple myeloma, ovarian, (212) 531-5965Keryx Biopharmaceuticals sarcoma)New York, NY

Reolysin® Oncolytics Biotech combination therapy Phase IIreovirus Calgary, Canada (see also brain, lung, sarcoma, skin) (403) 670-7377

SCH-58500 Schering-Plough (see also bladder, liver, Phase I(p53 gene therapy) Kenilworth, NJ lung, cancer-related) (908) 298-4000

sibrotuzumab Life Science (see also colorectal, lung) Phase IIPharmaceuticals (203) 422-6500Greenwich, CT

Tarceva® Genentech resected head/neck squamous Phase IIIerlotinib South San Francisco, CA cell cancer (650) 224-1000

OSI Pharmaceuticals (see also bladder, brain, breast, (800) 572-1932Melville, NY colorectal, liver, lung, other)


tegafur/uracil EMD Serono (see also colorectal) Phase IIcombination Rockland, MA (800) 283-8088

terameprocol Erimos Pharmaceuticals (see also brain, cervical) Phase IHouston, TX (713) 541-2000

Thymitaq® YM BioSciences (see also colorectal, liver, lung, Phase IInolatrexed Wayne, PA pancreatic, prostate) (610) 560-0600

TNFerade™ GenVec (see also colorectal, pancreatic, skin, Phase I/IIGaithersburg, MD stomach) (240) 632-0740

Tykerb® GlaxoSmithKline (see also brain, stomach) Phase IIIlapatinib Rsch. Triangle Park, NC (888) 825-5249

VB-4845 Viventia Biotech (see also bladder) Phase II(Orphan Drug) Mississauga, Canada (905) 361-8686

Vectibix™ Amgen first-line therapy Phase IIIpanitumumab Thousand Oaks, CA (see also lung) (805) 447-1000

--------------------------------------------------------------------------------------second-line therapy Phase II

(805) 447-1000

XL-880 Exelixis (see also kidney, stomach) Phase IISouth San Francisco, CA (650) 837-7000GlaxoSmithKline (888) 825-5249Rsch. Triangle Park, NC

zalutumumab Genmab Phase IIPrinceton, NJ (609) 430-2481



Zybrestat™ OXiGENE (see also lung, ovarian, other) Phase I/IIfosbretabulin Waltham, MA (781) 547-5900

K I D N E Y C A N C E RProduct Name Sponsor Indication Development Status

ABT-751 Abbott Laboratories (see also breast, colorectal, lung) Phase IIAbbott Park, IL (847) 937-6100

ABT-869 Abbott Laboratories (see also breast, liver, lung) Phase IIAbbott Park, IL (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

AGS-003 Argos Therapeutics metastatic renal cancer Phase IIDurham, NC (919) 287-6300

AMG 102 Amgen (see also brain, colorectal, Phase IIThousand Oaks, CA lung, stomach) (805) 447-1000

AMG 386 Amgen (see also breast, ovarian, Phase IIThousand Oaks, CA stomach, other) (805) 447-1000

Armala™ GlaxoSmithKline late-stage metastatic kidney cancer Phase IIIpazopanib Rsch. Triangle Park, NC (see also brain, breast, cervical, (888) 825-5249


AS-1411 Antisoma (see also leukemia) Phase II(Orphan Drug) Cambridge, MA (617) 225-0522

AV-951 AVEO Pharmaceuticals combination therapy Phase ICambridge, MA (see also lung, stomach) (617) 299-5000

Avastin® Genentech first-line metastatic renal cell carcinoma application submittedbevacizumab South San Francisco, CA (see also brain, colorectal, (650) 225-1000

head/neck, liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

axitinib Pfizer second-line therapy Phase IIINew York, NY (see also colorectal, lung, (860) 732-5156

solid tumors, other)

BAY 73-4506 Bayer HealthCare Phase IIPharmaceuticals (888) 842-2937Wayne, NJ

CA9-SCAN Wilex diagnosis of kidney cancer Phase IIIMunich, Germany www.wilex.com

cediranib AstraZeneca (see also breast, leukemia) Phase IIWilmington, DE (800) 236-9933

CNTO 328 Centocor (see also prostate) Phase IHorsham, PA (610) 651-6000

CYT-107 Cytheris (see also leukemia, skin, Phase I/IIRockville, MD solid tumors) (301) 231-0450



denenicokin ZymoGenetics combination therapy Phase II(IL-21) Seattle, WA (see also colorectal, lymphoma, (206) 442-6600

ovarian, skin)

dovitinib Novartis Pharmaceuticals (see also skin) Phase I/IIEast Hanover, NJ (888) 669-6682

EC-17 Endocyte combination therapy Phase IIWest Lafayette, IN (765) 463-7175

everolimus Novartis Pharmaceuticals (see also pancreatic, other) application submittedEast Hanover, NJ (888) 669-6682

GC-1008 Genzyme (see also skin) Phase ICambridge, MA (617) 252-7000

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IItopotecan Rsch. Triangle Park, NC head/neck, leukemia, lung, (888) 825-5249

lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

IMC-1121B Eli Lilly metastatic kidney cancer Phase IIIndianapolis, IN (see also breast, colorectal, liver, (800) 545-5979ImClone Systems lung, ovarian, prostate, skin) (212) 645-1405New York, NY

IMO-2055 Idera Pharmaceuticals (see also colorectal, lung) Phase II completedCambridge, MA (617) 679-5500

ispinesib CytoKinetics (see also breast, colorectal, Phase IISouth San Francisco, CA leukemia) (650) 624-3000

KRX-0402 Keryx Biopharmaceuticals (see also brain, colorectal, Phase INew York, NY multiple myeloma, sarcoma) (212) 531-5965

LOR-2040 Lorus Therapeutics metastatic kidney cancer Phase II(Orphan Drug) Toronto, Canada (see also breast, colorectal, leukemia) (416) 798-1200

MDX-1411 Medarex clear-cell renal cell carcinoma Phase IPrinceton, NJ (609) 430-2880

naptumomab Active Biotech (see also lung, pancreatic) Phase I completedestafenatox Lund, Sweden www.activebiotech.com

Oncophage® Antigenics (see also brain, colorectal, Phase IIvitespen New York, NY pancreatic, skin, stomach) (866) 805-8994

OncoVAX® Vaccinogen (see also colorectal, skin) Phase I/IIcancer vaccine Frederick, MD (301) 668-8400

ortataxel Spectrum Pharmaceuticals (see also lymphoma) Phase IIIrvine, CA (949) 788-6700

perifosine AEterna Zentaris (see also brain, head/neck, Phase IIMontreal, Canada lymphoma, multiple myeloma, (212) 531-5965Keryx Biopharmaceuticals ovarian, sarcoma)New York, NY

Rencarex® Wilex non-metastatic, clear cell renal Phase IIIW-G250 Munich, Germany cell carcinoma www.wilex.com(Orphan Drug)



romidepsin Gloucester Pharmaceuticals (see also lymphoma, multiple myeloma, Phase II completedCambridge, MA pancreatic, prostate) (617) 583-1300

RX-0201 Rexahn Pharmaceuticals late-stage kidney cancer Phase II(Orphan Drug) Rockville, MD (240) 268-5300

talactoferrin Agennix (see also lung) Phase II(Orphan Drug) Houston, TX (713) 552-1091

Torisel™ Wyeth Pharmaceuticals first-line therapy, late-stage kidney Phase IIItemsirolimus Collegeville, PA cancer (800) 934-5556(Orphan Drug) (see also colorectal, lung, lymphoma,

multiple myeloma, prostate)

tremelimumab Pfizer (see also breast, colorectal, lung, Phase INew York, NY prostate, skin) (860) 732-5156

TroVax® BioMedica Phase III(SAR109659) San Diego, CA (858) 677-6500

sanofi-aventis (800) 633-1610Bridgewater, NJ

Xcytrin® Pharmacyclics (see also brain, leukemia, lung, Phase IImotexafin Sunnyvale, CA lymphoma) (408) 774-0330gadolinium

XL-880 Exelixis (see also head/neck, stomach) Phase IISouth San Francisco, CA (650) 837-7000GlaxoSmithKline (888) 825-5249Rsch. Triangle Park, NC

Zolinza® Merck (see also brain, breast, colorectal, Phase I/IIvorinostat Whitehouse Station, NJ leukemia, lung, lymphoma, (800) 672-6372

multiple myeloma)

ZRx101 ZelleRx (see also multiple myeloma, skin, Phase IChicago, IL cancer-related) (312) 243-5200

ZYC300 Eisai (see also breast, colorectal, Phase IWoodcliff Lake, NJ ovarian, prostate) (888) 422-4743

L E U K E M I AProduct Name Sponsor Indication Development Status

ABIO05/01 Abiogen Pharma chronic myeloid leukemia (CML) Phase II(TALL-104) Pisa, Italy (combination therapy)

Ablvax™ Breakthrough Therapeutics CML Phase II(VAXICO) Greenwich, CT

ABT-263 Abbott Laboratories chronic lymphocytic leukemia (CLL) Phase I/IIAbbott Park, IL (see also lung, lymphoma) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

AC220 Ambit Biosciences acute myeloid leukemia (AML) Phase ISan Diego, CA (858) 334-2100



AEG-35156 Aegera Therapeutics AML Phase IIMontreal, Canada (combination therapy) (514) 288-5532

AEG-41174 Aegera Therapeutics hematological malignancies Phase IMontreal, Canada (combination therapy) (514) 288-5532

AEW541 Novartis Pharmaceuticals hematological malignancies Phase IEast Hanover, NJ (see also solid tumors) (888) 669-6682

Aezea™ Eleos AML, CLL Phase IIcenersen Omaha, NE (402) 255-5775

AFX-9154 Afecta Pharmaceuticals in clinical trialsIrvine, CA (949) 253-4688

ALD-151 Aldagen adjunctive treatment Phase IDurham, NC (adolescents and children) (919) 484-2571

alvocidib sanofi-aventis CLL Phase IIIBridgewater, NJ (800) 633-1610

ALXN-6000 Alexion Pharmaceuticals CLL Phase I/IICheshire, CT (203) 272-2596

annamycin Callisto Pharmaceuticals acute lymphocytic leukemia (ALL), Phase I/IIliposomal New York, NY AML (212) 297-0010(Orphan Drug)AP24534 ARIAD Pharmaceuticals hematological malignancies Phase I

Cambridge, MA (617) 494-0400

ARRY-520 Array BioPharma AML Phase I/IIBoulder, CO (see also solid tumors) (303) 381-6600

AS-1411 Antisoma AML (combination therapy) Phase IICambridge, MA (see also kidney) (617) 225-0522

AS-1413 Antisoma AML (combination therapy) Phase III(Orphan Drug) Cambridge, MA (617) 225-0522

AT9283 Astex Therapeutics hematological malignancies Phase I/IICambridge, United Kingdom (see also solid tumors)

atacicept EMD Serono CLL Phase I(TACI-Ig) Rockland, MA (see also lymphoma, (800) 283-8088

ZymoGenetics multiple myeloma) (206) 442-6600Seattle, WA

AVN-944 Avalon Pharmaceuticals hematological malignancies Phase IGermantown, MD (see also pancreatic) (301) 556-9900

AZD1152 AstraZeneca AML Phase I/IIWilmington, DE (800) 236-9933

AZD4877 AstraZeneca AML Phase I/IIWilmington, DE (see also lymphoma) (800) 236-9933

AZD6244 AstraZeneca AML Phase IIWilmington, DE (see also liver, lung, multiple (800) 236-9933

myeloma, ovarian, pancreatic,skin, other)

AZM475271 AstraZeneca hematological malignancies Phase IIWilmington, DE (see also solid tumors) (800) 236-9933



bafetinib CytRx ALL, CML Phase I(Orphan Drug) Los Angeles, CA (310) 826-5648

belinostat TopoTarget USA AML, myelodysplastic syndromes Phase IIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

liver, lung, lymphoma, ovarian)

Bexxar® GlaxoSmithKline CLL Phase Itositumomab Rsch. Triangle Park, NC (see also lymphoma, cancer-related) (888) 825-5249

bosutinib Wyeth Pharmaceuticals CML Phase IIICollegeville, PA (see also breast, solid tumors) (800) 934-5556

--------------------------------------------------------------------------------------ALL Phase I/II

(800) 934-5556

CAL-101 Calistoga Pharmaceuticals AML, CLL Phase ISeattle, WA (see also lymphoma) (206) 728-4700

Campath® Bayer HealthCare CLL Phase IIalemtuzumab Pharmaceuticals (888) 842-2937(subcutaneous) Wayne, NJ(Orphan Drug)carfilzomib Proteolix hematological malignancies Phase I

South San Francisco, CA (see also multiple myeloma, (650) 615-7550solid tumors)

CAT-8015 MedImmune CLL, hairy cell leukemia Phase IGaithersburg, MD (see also lymphoma) (301) 398-0000

cediranib AstraZeneca AML in children Phase IWilmington, DE (see also breast, kidney) (800) 236-9933

Ceflatonin® ChemGenex CML (second-line therapy) application submittedomacetaxine Pharmaceuticals (650) 474-9800mepesuccinate Menlo Park, CA --------------------------------------------------------------------------------------(Orphan Drug) AML, CML (combination therapy), Phase II

myelodysplastic syndromes (650) 474-9800

cell permeation MaxCyte CLL Phase I/IItherapeutic Gaithersburg, MD (301) 944-1700

Ceplene™ EpiCept AML Phase III completedhistamine Tarrytown, NY (914) 606-3500dehydrochloride(Orphan Drug)Clolar® Genzyme AML application submittedclofarabine Cambridge, MA (see also lymphoma) (617) 252-7500

--------------------------------------------------------------------------------------CLL, myelodysplastic syndromes Phase II

(617) 252-7500

CNF-2024 Biogen Idec CLL Phase ICambridge, MA (see also breast, solid tumors, (617) 679-2000

stomach)

CPX-351 Celator Pharmaceuticals AML Phase IIPrinceton, NJ (609) 243-0123



CYT-107 Cytheris myeloid leukemia Phase IRockville, MD (see also kidney, skin, solid tumors) (301) 231-0450

dacetuzumab Genentech CLL Phase I/II(anti-CD40) South San Francisco, CA (see also lymphoma, (650) 225-1000(Orphan Drug) Seattle Genetics multiple myeloma) (425) 527-4000

Bothell, WA

darinaparsin ZIOPHARM Oncology hematological malignancies Phase II(ZIO-101) New York, NY (see also liver, multiple myeloma, (646) 214-0700

solid tumors)

DCC-2036 Deciphera Pharmaceuticals ALL, CML Phase I/IILawrence, KS (785) 838-3767

Elacyt™ Clavis Pharma AML Phase IIelacytarabine Oslo, Norway (see also ovarian, skin) www.clavispharma.com(Orphan Drug)Fodosine™ BioCryst Pharmaceuticals CLL, leukemia Phase IIforodesine Birmingham, AL (see also lymphoma) (205) 444-4600

GCS-100 Prospect Therapeutics CLL Phase IIWoburn, MA (see also lymphoma, (781) 939-5750

multiple myeloma)

Genasense® Genta CLL application submittedoblimersen Berkeley Heights, NJ (see also breast, lung, lymphoma, (908) 286-9800(Orphan Drug) skin, solid tumors)

--------------------------------------------------------------------------------------AML Phase III

(908) 286-9800

gimatecan Novartis Pharmaceuticals myelodysplastic syndromes Phase IEast Hanover, NJ (see also brain) (888) 669-6682

Gleevec® Novartis Pharmaceuticals AML Phase IIimatinib East Hanover, NJ (see also prostate) (888) 669-6682

GRN-163L Geron CLL Phase I/IIMenlo Park, CA (see also breast, lung, (650) 473-7700

multiple myeloma)

GRNVAC1 Argos Therapeutics AML Phase IIDurham, NC (see also prostate) (919) 287-6300Geron (650) 473-7700Menlo Park, CA

GS-9219 Gilead Sciences CLL Phase I/IIFoster City, CA (see also lymphoma) (800) 445-3235

HRC-302 Hemosol BioPharma CML Phase IMississauga, Canada (905) 286-6349

Hycamtin® GlaxoSmithKline preleukemia Phase IIItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)--------------------------------------------------------------------------------------CML Phase II

(888) 825-5249



INNO-305 CytRx AML, myelodysplastic syndromes Phase ILos Angeles, CA (see also solid tumors) (310) 826-5648

ISF35 Memgen CLL Phase IDallas, TX (214) 731-3141

ispinesib CytoKinetics hematological malignancies Phase ISouth San Francisco, CA (see also breast, colorectal, (650) 624-3000

kidney)

JNJ-26481585 Johnson & Johnson refractory metastatic leukemia, Phase IPharmaceutical Research refractory metastatic (800) 817-5286& Development myelodysplastic syndromesRaritan, NJ

JVRS-100 Juvaris BioTherapeutics Phase IBurlingame, CA (650) 259-1800

KW-2449 Kyowa Pharmaceutical ALL, AML, CML, Phase IPrinceton, NJ myelodysplastic syndromes (609) 919-1100

laromustine Vion Pharmaceuticals AML (first-line therapy in elderly application submitted(VNP 40101M) New Haven, CT patients) (203) 498-4210(Orphan Drug) (see also brain)

--------------------------------------------------------------------------------------AML (combination second-line Phase IIItherapy) (203) 498-4210--------------------------------------------------------------------------------------AML (combination therapy in elderly Phase I/IIpatients), myelodysplastic syndromes (203) 498-4210(combination therapy in elderly patients)

lestaurtinib Cephalon AML Phase IIFrazer, PA (see also multiple myeloma) (610) 344-0200

Leukine® Bayer HealthCare CLL Phase IIsargramostim Pharmaceuticals (see also lymphoma, ovarian, (888) 842-2937

Wayne, NJ prostate, skin)

lintuzumab Facet Biotech AML (combination therapy in Phase II(SGN-33) Redwood City, CA elderly patients) (650) 454-1000(Orphan Drug) Seattle Genetics (425) 527-4000

Seattle, WA --------------------------------------------------------------------------------------myelodysplastic syndromes Phase I

(650) 454-1000(425) 527-4000

lintuzumab Actinium Pharmaceuticals AML Phase IAc-225 Florham Park, NJ (973) 377-0713

LOR-2040 Lorus Therapeutics AML Phase II(Orphan Drug) Toronto, Canada (see also breast, colorectal, kidney) (416) 798-1200

--------------------------------------------------------------------------------------CML, myelodysplastic Phase Isyndromes (416) 798-1200

lumilixmab Biogen Idec CLL Phase II/III(anti-CD23 mAb) Cambridge, MA (617) 679-2000



LY2181308 Eli Lilly AML Phase I/IIIndianapolis, IN (see also solid tumors) (800) 545-5979Isis Pharmaceuticals (760) 931-9200Carlsbad, CA

LymphoCide® Immunomedics ALL in children Phase IIepratuzumab Morris Plains, NJ (see also lymphoma) (973) 605-8200(Orphan Drug)Marqibo™ Hana Biosciences ALL Phase I/IIvincristine South San Francisco, CA (see also skin) (650) 588-6404liposomal(Orphan Drug)masitinib AB Science USA mastocytosis Phase III

Short Hills, NJ (see also pancreatic, stomach) (973) 218-2437

MDX-1342 Medarex CLL Phase IPrinceton, NJ (609) 430-2880

MGCD-0103 MethylGene AML, CLL, myelodysplastic syndromes Phase IIMontreal, Canada (see also lymphoma, solid tumors) (514) 337-3333

midostaurin Novartis Pharmaceuticals AML Phase III(PKC412) East Hanover, NJ (888) 669-6682

milatuzumab Immunomedics CLL Phase I/II(IMMU-115) Morris Plains, NJ (see lymphoma, multiple myeloma) (973) 605-8200

MK-0752 Merck hematological malignancies Phase IWhitehouse Station, NJ (see also breast) (800) 672-6372

MKC 1 EntreMed hematological malignancies Phase I completedRockville, MD (see aslo breast, lung, pancreatic) (240) 864-2600

MLN4924 Millennium hematological malignancies Phase IPharmaceuticals (see also solid tumors) (800) 390-5663Cambridge, MA

MLN8237 Millennium AML, myelodysplastic syndromes Phase IIPharmaceuticals (see also brain, lymphoma, (800) 390-5663Cambridge, MA solid tumors)

--------------------------------------------------------------------------------------ALL Phase I/II

(800) 390-5663

MPC-2130 Myriad Pharmaceuticals hematological malignancies Phase ISalt Lake City, UT (801) 584-3600

Nipent® Hospira CLL Phase IIIpentostatin Lake Forest, IL (see also lymphoma, cancer-related) (224) 212-2000(Orphan Drug)Nplate™ Amgen myelodysplastic syndromes Phase IIromiplostim Thousand Oaks, CA (see also cancer-related) (805) 447-1000

obatoclax Gemin X Biotechnologies AML in elderly patients, Phase IIMontreal, Canada myelodysplastic syndromes (514) 281-8989

(see also lung, lymphoma)--------------------------------------------------------------------------------------CLL Phase I/II completed

(514) 281-8989



ofatumumab GlaxoSmithKline CLL (second-line therapy) application submittedRsch. Triangle Park, NC (see also lymphoma) (888) 825-5249

--------------------------------------------------------------------------------------CLL (first-line therapy) Phase III

(888) 825-5249

ON-01910 Onconova Therapeutics AML, myelodysplastic syndromes Phase IPrinceton, NJ (see also solid tumors) (609) 844-7735

OVI-123 OncoVista TdT-positive leukemia Phase I/II(Orphan Drug) San Antonio, TX (210) 677-6000

panobinostat Novartis Pharmaceuticals CML Phase II/III completedEast Hanover, NJ (see also brain, breast, lymphoma, (888) 669-6682

prostate)--------------------------------------------------------------------------------------AML Phase II

(888) 669-6682

PCI-24781 Pharmacyclics hematological malignancies Phase IISunnyvale, CA (see also solid tumors) (408) 774-0330

PEG-Intron A® Schering-Plough CML Phase IIpeginterferon Kenilworth, NJ (see also skin) (908) 298-4000alfa-2b

PHA-739358 Nerviano Medical Sciences CML Phase IINerviano, Italy www.nervianoms.com

polyphenon E Polyphenon Pharma CLL Phase I/II(Orphan Drug) New York, NY (see also bladder, prostate) (212) 661-0578

PR1 cancer Vaccine Company AML Phase IIIvaccine South San Francisco, CA (650) 244-4100

--------------------------------------------------------------------------------------CML, myelodysplastic syndromes Phase II

(650) 244-4100

PRO-131921 Genentech CLL Phase I/IISouth San Francisco, CA (see also lymphoma) (650) 224-1000

Proleukin® Novartis Pharmaceuticals AML Phase IIIaldesleukin East Hanover, NJ (888) 669-6682

PS-095760 Ligand Pharmaceuticals (see also lung) Phase IISan Diego, CA (858) 550-7500Schering-Plough (908) 298-4000Kenilworth, NJ

R7112 Roche hematological malignancies Phase INutley, NJ (see also solid tumors) (973) 235-5000

recombinant Rare Disease Therapeutics ALL Phase I/IIWolinella Nashville, TN (615) 399-0700succinogenes asparaginase (rWS)



Revlimid® Celgene CLL Phase IIIlenalidomide Summit, NJ (see also lymphoma, multiple (908) 673-9000

myeloma, prostate, other)--------------------------------------------------------------------------------------AML Phase II

(908) 673-9000

Rituxan® Biogen Idec relapsed CLL Phase IIIrituxumab Cambridge, MA (617) 679-2000


RTA-402 Reata Pharmaceuticals hematological malignancies Phase IDallas, TX (see also pancreatic) (972) 865-2200

sapacitabine Cyclacel Pharmaceuticals AML in elderly patients, Phase IIShort Hills, NJ myelodysplastic syndromes in (973) 847-5955

elderly patients(see also lung, lymphoma)

Sarasar™ Schering-Plough myelodysplastic syndromes Phase IIIlonafarnib Kenilworth, NJ (see also breast, pancreatic) (908) 298-4000

--------------------------------------------------------------------------------------leukemia Phase II

(908) 298-4000

SB-1518 S*Bio (see also lymphoma) Phase IRedwood City, CA (650) 730-2860

SCH-727965 Schering-Plough (see also breast, lung) Phase IIKenilworth, NJ (908) 298-4000

SGN-35 Seattle Genetics hematological malignancies Phase IBothell, WA (see also lymphoma) (425) 527-4000

SL-401 Stemline Therapeutics AML Phase I/IINew York, NY (212) 831-1111

SNS-595 Sunesis Pharmaceuticals AML in elderly patients Phase IISouth San Francisco, CA (see also ovarian) (650) 266-3500

--------------------------------------------------------------------------------------AML (combination therapy) Phase I/II

(650) 266-3500--------------------------------------------------------------------------------------AML (monotherapy) Phase I

(650) 266-3500

SPC-2996 Santaris Pharma CLL Phase I/II completedHorsholm, Denmark

Sprycel™ Bristol-Myers Squibb first-line CML Phase IIIdasatinib Princeton, NJ (see also prostate, solid tumors) (212) 546-4000

--------------------------------------------------------------------------------------other hematological malignancies in clinical trials

(212) 546-4000

STA-9090 Synta Pharmaceuticals hematological malignancies Phase I/IILexington, MA (see also solid tumors) (781) 274-8200



StemEx® Gamida Cell hematological malignancies Phase II/IIIhematopoietic Jerusalem, Israel (215) 591-3000stem cell therapy Teva Pharmaceuticals USA(Orphan Drug) North Wales, PA

TAK901 Millennium hematological malignancies Phase IPharmaceuticals (800) 390-5663Cambridge, MA

tamibarotene CytRx APL Phase II(Orphan Drug) Los Angeles, CA (310) 826-5648

Tasigna® Novartis Pharmaceuticals CML (first-line therapy) Phase IInilotinib East Hanover, NJ (see also stomach) (888) 669-6682(Orphan Drug)tasisulam (ASAP) Eli Lilly AML Phase I

Indianapolis, IN (see also ovarian, sarcoma, skin) (800) 545-5979

Telintra® Telik myelodysplastic syndromes Phase IIezatiostat Palo Alto, CA (see also cancer-related) (650) 845-7700

Temodar® Schering-Plough AML Phase IItemozolomide Kenilworth, NJ (see also lung) (908) 298-4000

Triapine® Vion Pharmaceuticals leukemia Phase IINew Haven, CT (see also lung, pancreatic, prostate) (203) 498-4210

--------------------------------------------------------------------------------------hematological malignancies Phase I

(203) 498-4210

tricirbine VioQuest Pharmaceuticals hematological malignancies Phase I/II(VQD-002) Basking Ridge, NJ (see also solid tumors) (908) 766-4400

Trisenox® Cephalon AML in elderly patients Phase IIIarsenic trioxide Frazer, PA (combination therapy) (610) 344-0200

(see also brain, multiple myeloma)

TRU-016 Trubion Pharmaceuticals CLL Phase I/IISeattle, WA (206) 838-0500

Vidaza® Celgene AML, myelodysplastic syndromes Phase Iazacitidine Summit,NJ (see also lymphoma, prostate) (908) 673-9000(Orphan Drug)VP101 Access Pharmaceuticals hematological malignancies Phase II

Dallas, TX (see also brain, colorectal, prostate) (214) 905-5100

VP701 Virium Pharmaceuticals Phase IPrinceton, NJ (609) 951-2270

Xcytrin® Pharmacyclics CLL Phase IImotexafin Sunnyvale, CA (see also brain, kidney, lung, (408) 774-0330gadolinium lymphoma)

XL-228 Exelixis ALL, CML Phase ISouth San Francisco, CA (650) 837-7000

Zarnestra™ Johnson & Johnson AML Phase IIItipifarnib Pharmaceutical Research (see also pancreatic) (800) 817-5286




Zolinza® Merck AML, myelodysplastic syndromes Phase IIvorinostat Whitehouse Station, NJ (see also brain, breast, colorectal, (800) 672-6372

kidney, lung, lymphoma, multiple myeloma)

zosuquidar Kanisa Pharmaceuticals AML in elderly patients Phase I/IISan Diego, CA (858) 436-1800

L I V E R C A N C E RProduct Name Sponsor Indication Development Status

ABT-869 Abbott Laboratories (see also breast, kidney, lung) Phase IIAbbott Park, IL (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

amsilarotene Taiho Pharma USA Phase I/IIPrinceton, NJ (609) 750-5300

Armala™ GlaxoSmithKline (see also brain, breast, cervical, Phase Ipazopanib Rsch. Triangle Park, NC kidney, lung, ovarian, sarcoma, other) (888) 825-5249

ARQ-197 ArQule hepatocellular carcinoma Phase IWoburn, MA (see also lung, pancreatic, (781) 994-0300Daiichi Sankyo solid tumors) (973) 359-2600Parsippany, NJ

Avastin® Genentech (see also brain, colorectal, Phase IIbevacizumab South San Francisco, CA head/neck, kidney, lung, lymphoma, (650) 225-1000


AZD6244 AstraZeneca biliary cancer, liver cancer Phase IIWilmington, DE (see also leukemia, lung, multiple (800) 236-9933

myeloma, ovarian, pancreatic, skin, other)

batabulin Amgen Phase IIIThousand Oaks, CA (805) 447-1000

belinostat TopoTarget USA inoperable/unresectable liver cancer Phase I/IIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

leukemia, lung, lymphoma, ovarian)

brivanib Bristol-Myers Squibb hepatocellular carcinoma Phase III(VEGFR/FGFR Princeton, NJ (see also colorectal) (212) 546-4000kinase inhibitor)

CRS-100 Cerus Phase IConcord, CA (925) 288-6000

darinaparsin ZIOPHARM Oncology (see also leukemia, Phase II completed(ZIO-101) New York, NY multiple myeloma, solid tumors) (646) 214-0700

DENSPM Genzyme Phase I/II(Orphan Drug) Cambridge, MA (617) 252-7500



doxorubicin Delcath Systems Phase II(percutaneous New York, NY (212) 489-2100hepatic perfusion)

EHC-18 Enzo BioChem Phase INew York, NY (212) 583-0100

eniluracil Adherex Technologies (see also solid tumors) Phase I/IIDurham, NC (919) 484-8484

ferucarbotran Bayer HealthCare liver cancer imaging application submittedPharmaceuticals (888) 842-2937Wayne, NJ

GC-33 Chugai Pharma USA Phase IBerkeley Heights, NJ (908) 516-1350

IMC-1121B Eli Lilly (see also breast, colorectal, kidney, Phase IIIndianapolis, IN lung, ovarian, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also breast, colorectal, Phase IIIndianapolis, IN head/neck, lung, pancreatic, (800) 545-5979ImClone Systems prostate, sarcoma, solid tumors) (212) 645-1405New York, NY

irinotecan Biocompatibles metastatic liver cancer from Phase IIeluting beads International colorectal cancer www.biocompatibles.com

Surrey, United Kingdom

JX-594 Jennerex Biotherapeutics (see also solid tumors) Phase IISan Francisco, CA (415) 281-8886

mapatumumab Human Genome Sciences (see also lung, multiple myeloma) Phase I/IIRockville, MD (301) 309-8504

MB-7133 Metabasis Therapeutics inoperable, unresectable Phase I/II(Orphan Drug) La Jolla, CA liver cancer (858) 587-2770

melphalan drug Delcath Systems Phase IIIdelivery system New York, NY (212) 489-2100

NV1020 MediGene Phase I/IISan Diego, CA (858) 586-2240

patupilone Novartis Pharmaceuticals (see also brain, breast, colorectal, Phase II(EPO906) East Hanover, NJ lung, ovarian) (888) 669-6682

Photofrin® PDT Axcan Pharma cholangiocarcinoma Phase IIporfimer sodium Birmingham, AL (205) 991-8085

PR-104 Proacta Therapeutics (see also lung) Phase ISan Diego, CA (858) 642-0386

SCH-58500 Schering-Plough (see also bladder, head/neck, Phase I(p53 gene therapy) Kenilworth, NJ lung, cancer-related) (908) 298-4000

Sutent® Pfizer (see also breast, colorectal, lung, Phase IIIsunitinib New York, NY pancreatic, prostate, sarcoma, (860) 732-5156

stomach)



tacatuzumab-Y-90 Immunomedics Phase I(IMMU-105) Morris Plains, NJ (973) 605-8200

Tarceva® Genentech (see also bladder, brain, breast, Phase IIerlotinib South San Francisco, CA colorectal, head/neck, lung, other) (650) 224-1000

OSI Pharmaceuticals (800) 572-1932Melville, NY

Thermodox™ Celsion inoperable, unresectable liver cancer Phase IIILTSDEL Columbia, MD (see also breast) (410) 290-5390

Thymitaq® YM BioSciences (see also colorectal, head/neck, Phase IIInolatrexed Wayne, PA lung, pancreatic, prostate) (610) 560-0600(Orphan Drug)TJ9 Tsumura Phase II

Tokyo, Japan www.tsumura.co.jp

L U N G C A N C E RProduct Name Sponsor Indication Development Status

1572932A GlaxoSmithKline non-small-cell lung cancer (NSCLC) Phase IIIRsch. Triangle Park, NC (888) 825-5249

Abraxane™ Abraxis BioScience NSCLC Phase IIIalbumin-bound Los Angeles, CA (see also head/neck, ovarian, (310) 883-1300paclitaxel pancreatic, prostate, skin)

ABT-263 Abbott Laboratories small-cell-lung cancer (SCLC) Phase I/IIAbbott Park, IL (see also leukemia, lymphoma) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

ABT-751 Abbott Laboratories NSCLC Phase IIAbbott Park, IL (see also breast, colorectal, kidney) (847) 937-6100

ABT-869 Abbott Laboratories NSCLC Phase IIAbbott Park, IL (see also breast, kidney, liver) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

Actimid™ Celgene SCLC (combination therapy) Phase I/IIpomalidomide Summit, NJ (see also multiple myeloma, (908) 673-9000

pancreatic, prostate, sarcoma)

Advexin® Introgen Therapeutics NSCLC (combination therapy) Phase IIcontusugene Austin, TX (see also bladder, brain, breast, (512) 708-9310ladenovec head/neck, ovarian, prostate,

stomach)--------------------------------------------------------------------------------------bronchioloalveolar adenocarcinoma Phase I

(512) 708-9310

aflibercept sanofi-aventis second-line NSCLC Phase III(VEGF-trap) Bridgewater, NJ (combination therapy) (800) 633-1610

Regeneron Pharmaceuticals (see also colorectal, pancreatic, (914) 345-7400Tarrytown, NY prostate, other)



Alimta® Eli Lilly NSCLC (maintenance therapy) Phase IIIpemetrexed Indianapolis, IN (see also breast, head/neck, ovarian) (800) 545-5979

AMG 102 Amgen SCLC Phase I/IIThousand Oaks, CA (see also brain, colorectal, (805) 447-1000

kidney, stomach)

AMG 479 Amgen (see also breast, colorectal, Phase IIThousand Oaks, CA pancreatic, sarcoma) (805) 447-1000

Amplimexon® AmpliMed (see also breast, multiple myeloma, Phase Iimexon Tucson, AZ pancreatic, prostate, skin) (520) 529-1000

amrubicin Celgene SCLC (second-line therapy) Phase III(Orphan Drug) Summit, NJ (908) 673-9000

ANZ-207 Anza Therapeutics mesothelioma, NSCLC Phase IConcord, CA (see also ovarian, pancreatic) (925) 288-6000

apomab Genentech NSCLC (combination therapy) Phase IISouth San Francisco, CA (see also colorectal, lymphoma) (650) 225-1000

Armala™ GlaxoSmithKline NSCLC Phase IIpazopanib Rsch. Triangle Park, NC (see also brain, breast, cervical, (888) 825-5249

kidney, liver, ovarian, sarcoma, other)

ARQ-197 ArQule NSCLC Phase I/IIWoburn, MA (see also liver, pancreatic, (781) 994-0300Daiichi Sankyo solid tumors) (973) 359-2600Parsippany, NJ

AT-101 Ascenta Therapeutics NSCLC, SCLC Phase IISan Diego, CA (see also lymphoma, prostate) (858) 436-1200

AV-951 AVEO Pharmaceuticals NSCLC Phase I/IICambridge, MA (see also kidney, stomach) (617) 299-5000

Avastin® Genentech SCLC Phase IIbevacizumab South San Francisco, CA (see also brain, colorectal, (650) 225-1000

head/neck, kidney, liver, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

axitinib Pfizer NSCLC (first-line therapy) Phase IINew York, NY (see also colorectal, kidney, (860) 732-5156

solid tumors, other)

AZD6244 AstraZeneca NSCLC Phase IIWilmington, DE (see also leukemia, liver, (800) 236-9933

multiple myeloma, ovarian, pancreatic, skin, other)

belinostat TopoTarget USA mesothelioma Phase IIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

leukemia, liver, lymphoma, ovarian, stomach)

BIBF 1120 Boehringer Ingelheim NSCLC Phase IIIPharmaceuticals (see also solid tumors) (800) 243-0127Ridgefield, CT



BIBW 2992 Boehringer Ingelheim NSCLC (second-line therapy) Phase II/IIIPharmaceuticals (see also brain, breast, head/neck) (800) 243-0127Ridgefield, CT

BMS-690514 Bristol-Myers Squibb (see also solid tumors) in clinical trials(ErbB/VEGF Princeton, NJ (212) 546-4000receptor inhibitor)

Camptosar® Pfizer (see also cervical, pancreatic, application submittedirinotecan New York, NY prostate) (860) 732-5156

canertinib Pfizer NSCLC Phase IINew York, NY (860) 732-5156

Capoxigem® Tragara Pharmaceuticals NSCLC (combination therapy) Phase IIapricoxib San Diego, CA (see also breast, pancreatic) (858) 350-6900

CBP501 Millennium mesothelioma (combination therapy) Phase IIPharmaceuticals (see also solid tumors) (800) 390-5663Cambridge, MA

cisplatin Transave Phase IIliposomal Monmouth Junction, NJ (732) 438-9434

conatumumab Amgen NSCLC Phase I/IIThousand Oaks, CA (see also colorectal, pancreatic, (805) 447-1000

sarcoma)

CP-751871 Pfizer NSCLC (combination therapy), Phase IIINew York, NY metastatic disease (860) 732-5156

(see also breast, colorectal, multiple myeloma, prostate, sarcoma)--------------------------------------------------------------------------------------NSCLC (combination first-line Phase I/IItherapy) (860) 732-5156

CS-1017 Daiichi Sankyo NSCLC Phase IIParsippany, NJ (see also other) (973) 359-2600

deforolimus ARIAD Pharmaceuticals NSCLC Phase II(MK-8669) Cambridge, MA (see also breast, prostate, sarcoma, (617) 494-0400

Merck other) (800) 672-6372Whitehouse Station, NJ

diflomotecan Biomeasure (Ipsen) SCLC Phase IIMilford, MA (508) 478-0144

DMXAA Antisoma NSCLC (first-line therapy) Phase IIICambridge, MA (see also prostate) (617) 225-0522Novartis Pharmaceuticals (888) 669-6682East Hanover, NJ

doxorubicin Zivena Phase IIinhaled Columbus, OH (614) 340-2370

EC-145 Endocyte late-stage NSCLC Phase IIWest Lafayette, IN (see also ovarian, other) (765) 463-7175



Erbitux® Bristol-Myers Squibb advanced NSCLC, Phase IIIcetuximab Princeton, NJ locally advanced NSCLC, (212) 546-4000

Eli Lilly first-line, second-line (800) 545-5979Indianapolis, IN (see also bladder, colorectal, (212) 645-1405ImClone Systems head/neck, prostate, stomach)New York, NY

eribulin mesylate Eisai NSCLC Phase II(E7389) Woodcliff Lake, NJ (see also breast, head/neck, ovarian, (888) 422-4743

prostate, sarcoma, solid tumors)

Gemzar® Eli Lilly metastatic SCLC Phase IIgemcitabine Indianapolis, IN (see also head/neck, lymphoma, (800) 545-5979

sarcoma)

Genasense® Genta NSCLC Phase II/IIIoblimersen Berkeley Heights, NJ (see also breast, leukemia, (908) 286-9800

lymphoma, skin, solid tumors)

GI-4000 GlobeImmune NSCLC Phase IILouisville, CO (see also pancreatic) (303) 625-2700

glufosfamide Threshold Pharmaceuticals SCLC Phase IIRedwood City, CA (see also breast, pancreatic, sarcoma) (650) 474-8200

GRN-163L Geron NSCLC (combination therapy) Phase IMenlo Park, CA (see also breast, leukemia, (650) 473-7700

multiple myeloma)

Hycamtin® GlaxoSmithKline NSCLC Phase IIItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, leukemia, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

HyperAcute® Lung NewLink Genetics NSCLC Phase I/IIlung cancer Ames, IA (515) 296-5555vaccine

IMC-1121B Eli Lilly NSCLC Phase IIIndianapolis, IN (see also breast, colorectal, kidney, (800) 545-5979ImClone Systems liver, ovarian, prostate, skin) (212) 645-1405New York, NY

IMC-A12 Eli Lilly NSCLC (combination therapy) Phase IIIndianapolis, IN (see also breast, colorectal, (800) 545-5979ImClone Systems head/neck, liver, pancreatic, (212) 645-1405New York, NY prostate, sarcoma, solid tumors)

IMGN-901 ImmunoGen SCLC Phase IICambridge, MA (see also multiple myeloma) (617) 995-2500

IMO-2055 Idera Pharmaceuticals NSCLC (second-line therapy) Phase ICambridge, MA (see also colorectal, kidney) (617) 679-5500

INGN 225 Introgen Therapeutics SCLC Phase II(p53 vaccine) Austin, TX (see also breast) (512) 708-9310

INGN 401 Introgen Therapeutics NSCLC Phase I(nano-FUS-1) Austin, TX (512) 708-9310



Ixempra™ Bristol-Myers Squibb NSCLC in clinical trialsixabepilone Princeton, NJ (see also breast, pancreatic, prostate) (212) 546-4000

JNJ-26854165 Johnson & Johnson NSCLC Phase IPharmaceutical Research (see also prostate) (800) 817-5286& DevelopmentRaritan, NJ

Karenitecin® BioNumerik NSCLC (intravenous) Phase IIcositecan Pharmaceuticals (see also brain, ovarian, skin) (210) 614-1701

San Antonio, TX --------------------------------------------------------------------------------------NSCLC (oral) Phase I/II

(210) 614-1701

Levulan® PD DUSA Pharmaceuticals (see also bladder, cervical, in clinical trialsaminolevulinic acid Wilmington, MA colorectal, stomach) (978) 657-7500

Lucanix® NovaRx NSCLC Phase IIIbelagenpumatucel-L San Diego, CA (see also brain) (858) 552-8600

lung cancer AVAX Technologies NSCLC Phase I/IIvaccine Philadelphia, PA (215) 241-9760

lung cancer Pfizer NSCLC Phase Ivaccine New York, NY (860) 732-5156(NY-ESO-1)

mapatumumab Human Genome Sciences NSCLC Phase IIRockville, MD (see also liver, multiple myeloma) (301) 309-8504

milataxel Taxolog NSCLC Phase IIFairfield, NJ (see also breast, colorectal) (877) 829-6564

MK-0646 Merck NSCLC Phase I/IIWhitehouse Station, NJ (see also breast, pancreatic, other) (800) 672-6372

MKC 1 EntreMed NSCLC Phase IIRockville, MD (see also breast, leukemia, pancreatic) (240) 864-2600

MORAb-009 Eisai mesothelioma Phase IIWoodcliff Lake, NJ (see also ovarian, pancreatic) (888) 422-4743

--------------------------------------------------------------------------------------NSCLC Phase I

(888) 422-4743

motesanib Amgen NSCLC (combination therapy) Phase IIIThousand Oaks, CA (see also breast, colorectal, other) (805) 447-1000Millennium (800) 390-5663PharmaceuticalsCambridge, MA

naptumomab Active Biotech NSCLC Phase I completedestafenatox Lund, Sweden (see also kidney, pancreatic) www.activebiotech.com

neratinib Wyeth Pharmaceuticals NSCLC Phase II(HKI272) Collegeville, PA (see also breast) (800) 934-5556



Nexavar® Bayer HealthCare NSCLC (combination therapy) Phase IIIsorafenib Pharmaceuticals (see also breast, skin) (888) 842-2837

Wayne, NJ (510) 597-6500Onyx Pharmaceuticals --------------------------------------------------------------------------------------Emeryville, CA SCLC Phase II

(888) 842-2837(510) 597-6500

NOV-002 Novelos Therapeutics NSCLC Phase IIINewton, MA (combination first-line therapy) (617) 244-1616

(see also breast, ovarian)

NPI-2358 Nereus Pharmaceuticals NSCLC Phase ISan Diego, CA (see also lymphoma) (858) 587-4090

obatoclax Gemin X Biotechnologies NSCLC, SCLC (combination therapy) Phase I/IIMontreal, Canada (see also leukemia, lymphoma) (514) 281-8989

OBP-301 Oncolys Biopharma mesothelioma Phase ITokyo, Japan (see also breast, head/neck) www.oncolys.com

OGX-011 Isis Pharmaceuticals NSCLC Phase I/II(ISIS-112989) Carlsbad, CA (760) 931-9200

Oncogenex (425) 686-1500PharmaceuticalsBothell, WA

OGX-427 Oncogenex NSCLC Phase IPharmaceuticals (see also bladder, breast, ovarian, (425) 686-1500Bothell, WA prostate)

Onconase® Alfacell mesothelioma Phase IIIranpirnase Bloomfield, NJ (combination therapy) (973) 748-8082(Orphan Drug) Strativa Pharmaceuticals --------------------------------------------------------------------------------------

Woodcliff Lake, NJ NSCLC Phase I/II(973) 748-8082

Opaxio™ Cell Therapeutics NSCLC Phase IIIpaclitaxel Seattle, WA (see also ovarian, stomach, other) (800) 215-2355poliglumex Novartis Pharmaceuticals (888) 669-6682

East Hanover, NJ

P-2045 Antisoma NSCLC, SCLC Phase ICambridge, MA (617) 225-0522

patupilone Novartis Pharmaceuticals NSCLC Phase II(EPO906) East Hanover, NJ (see also brain, breast, colorectal, (888) 669-6682

liver, ovarian)

pelitinib Wyeth Pharmaceuticals NSCLC (second-line therapy) Phase II(EKB569) Collegeville, PA (see also colorectal) (800) 934-5556

PF-299804 Pfizer NSCLC Phase IINew York, NY (860) 732-5156

picoplatin Poniard Pharmaceuticals SCLC Phase II(Orphan Drug) Seattle, WA (see also colorectal) (206) 281-7001

plitidepsin PharmaMar USA SCLC Phase IICambridge, MA (see also multiple myeloma, prostate) (617) 868-3797



PR-104 Proacta Therapeutics NSCLC, SCLC Phase IISan Diego, CA (see also liver) (858) 642-0386

pralatrexate Allos Therapeutics NSCLC Phase II(PDX) Westminster, CO (see also bladder, lymphoma) (303) 426-6262

ProMune® Pfizer NSCLC Phase IIagatolimod New York, NY (860) 732-5156

PS-095760 Ligand Pharmaceuticals NSCLC Phase IISan Diego, CA (see also leukemia) (858) 550-7500Schering-Plough (908) 298-4000Kenilworth, NJ

R1454 Roche NSCLC Phase INutley, NJ (973) 235-5000

R1507 Roche NSCLC (combination therapy) Phase IINutley, NJ (see also breast, lymphoma, sarcoma) (973) 235-5000

Reolysin® Oncolytics Biotech NSCLC (combination therapy) Phase IIreovirus Calgary, Canada (see also brain, head/neck, sarcoma, (403) 670-7377

skin)

retaspimycin Infinity Pharmaceuticals NSCLC Phase II(IPI 504) Cambridge, MA (see also breast, stomach) (617) 453-1000

S-1 Taiho Pharma USA NSCLC Phase IIPrinceton, NJ (609) 750-5300

salirasib Concordia Pharmaceuticals NSCLC Phase IIFt. Lauderdale, FL (see also pancreatic) www.concordiapharma.com

sapacitabine Cyclacel Pharmaceuticals NSCLC Phase IIShort Hills, NJ (see also leukemia, lymphoma) (973) 847-5955

satraplatin Spectrum Pharmaceuticals NSCLC (combination therapy) Phase IIIrvine, CA (see also breast, prostate) (949) 788-6700

SCH-58500 Schering-Plough NSCLC Phase II(p53 gene therapy) Kenilworth, NJ (see also bladder, head/neck, (908) 298-4000

liver, cancer-related)

SCH-727965 Schering-Plough NSCLC Phase IIKenilworth, NJ (see also breast, leukemia)) (908) 298-4000

seliciclib Cyclacel Pharmaceuticals NSCLC Phase IIShort Hills, NJ (see also other) (973) 847-5955

sibrotuzumab Life Science NSCLC Phase IIPharmaceuticals (see also colorectal, head/neck) (203) 422-6500Greenwich, CT

SNDX-275 Syndax Pharmaceuticals NSCLC Phase I/IIWaltham, MA (see also breast) (781) 839-7301

Stimuvax® EMD Serono NSCLC Phase IIIBLP25 liposomal Rockland, MA (800) 283-8088cancer vaccine Oncothyreon (425) 450-0370

Bellevue, WA



Sutent® Pfizer NSCLC (combination therapy, Phase IIIsunitinib New York, NY second-line therapy) (860) 732-5156

(see also breast, colorectal, liver, pancreatic, prostate, sarcoma, stomach)

talactoferrin Agennix NSCLC Phase III(Orphan Drug) Houston, TX (see also kidney) (713) 552-1091

Tarceva® Genentech NSCLC (combination therapy) Phase IIIerlotinib South San Francisco, CA (see also bladder, brain, breast, (650) 225-1000

OSI Pharmaceuticals colorectal, head/neck, liver, (800) 572-1932Melville, NY other)

Telcyta™ Telik NSCLC (third-line therapy) Phase IIIcanfosfimide Palo Alto, CA (see also breast, colorectal, (650) 845-7700

ovarian)

Temodar® Schering-Plough SCLC Phase IItemozolomide Kenilworth, NJ (see also leukemia) (908) 298-4000

TG-4010 Transgene Phase IKensington, MD (301) 816-5404

Thymitaq® YM BioSciences (see also colorectal, head/neck, liver, Phase IInolatrexed Wayne, PA pancreatic, prostate) (610) 560-0600

topotecan Hana Biosciences SCLC Phase Iliposomal South San Francisco, CA (see also ovarian) (650) 588-6404

Torisel™ Wyeth Pharmaceuticals NSCLC Phase IItemsirolimus Collegeville, PA (see also colorectal, kidney, (800) 934-5556

lymphoma, multiple myeloma, prostate)

tremelimumab Pfizer NSCLC Phase IINew York, NY (see also breast, colorectal, kidney, (860) 732-5156

prostate, skin)

Triapine® Vion Pharmaceuticals NSCLC Phase IINew Haven, CT (see also leukemia, pancreatic, (203) 498-4210

prostate)

tucotuzumab EMD Serono NSCLC, SCLC Phase IIcelmoleukin Rockland, MA (see also colorectal, ovarian, (800) 283-8088

prostate)

Vectibix™ Amgen NSCLC Phase IIpanitumumab Thousand Oaks, CA (see also head/neck) (805) 447-1000

Velcade® Millennium NSCLC (combination therapy, Phase IIbortezomib Pharmaceuticals metastatic disease, monotherapy, (800) 390-5663

Cambridge, MA second-line therapy)(see also lymphoma, multiple myeloma, solid tumors)

volociximab Biogen Idec NSCLC Phase IICambridge, MA (see also ovarian, pancreatic, skin) (617) 679-2000Facet Biotech (650) 454-1000Redwood City, CA



Xcytrin® Pharmacyclics NSCLC Phase IImotexafin Sunnyvale, CA (see also brain, kidney, leukemia, (408) 774-0330gadolinium lymphoma)

XL-647 Exelixis NSCLC (first-line therapy, Phase IISouth San Francisco, CA second-line therapy) (650) 837-7000

Zactima™ AstraZeneca NSCLC Phase IIIvandetanib Wilmington, DE (see also brain, breast, other) (800) 236-9933

--------------------------------------------------------------------------------------SCLC Phase II

(800) 236-9933

Zolinza® Merck mesothelioma Phase IIIvorinostat Whitehouse Station, NJ (see also brain, breast, colorectal, (800) 672-6372

kidney, leukemia, lymphoma, multiple myeloma)

Zybrestat™ OXiGENE NSCLC (first-line therapy) Phase IIfosbretabulin Waltham, MA (see also head/neck, ovarian, other) (781) 547-5900

L Y M P H O M AProduct Name Sponsor Indication Development Status

461364 GlaxoSmithKline non-Hodgkin’s lymphoma Phase IRsch. Triangle Park, NC (see also solid tumors) (888) 825-5249

690693 GlaxoSmithKline (see also solid tumors) Phase IRsch. Triangle Park, NC (888) 825-5249

743921 Cytokinetics non-Hodgkin’s lymphoma Phase I/IISouth San Francisco, CA (650) 624-3000

--------------------------------------------------------------------------------------Hodgkin’s disease Phase I

(650) 624-3000

1018 ISS Dynavax Technologies non-Hodgkin’s lymphoma Phase IIBerkeley, CA (see also colorectal) (510) 848-5100

ABT-263 Abbott Laboratories (see also leukemia, lung) Phase I/IIAbbott Park, IL (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

AME-133 Applied Molecular non-Hodgkin’s lymphoma Phase I/IIEvolution (858) 597-4990San Diego, CA

AMG 951 Amgen non-Hodgkin’s lymphoma Phase II(rhApo2L/TRAIL) Thousand Oaks, CA (see also colorectal) (805) 447-1000


apomab Genentech non-Hodgkin’s lymphoma Phase IISouth San Francisco, CA (combination therapy) (650) 225-1000

(see also colorectal, lung)



AR-726 Antigenics non-Hodgkin’s lymphoma Phase INew York, NY (see also colorectal) (212) 994-8200

AT-101 Ascenta Therapeutics non-Hodgkin’s lymphoma Phase IISan Diego, CA (see also lung, prostate) (858) 436-1200

atacicept EMD Serono non-Hodgkin’s lymphoma Phase I(TACI-Ig) Rockland, MA (see also leukemia, (800) 283-8088

ZymoGenetics multiple myeloma) (206) 442-6600Seattle, WA

AV-299 AVEO Pharmaceuticals (see also solid tumors) Phase I(SCH-90015) Cambridge, MA (617) 299-5000

Schering-PloughKenilworth, NJ

Avastin® Genentech diffuse large B-cell lymphoma Phase IIIbevacizumab South San Francisco, CA (first-line therapy) (650) 225-1000

(see also brain, colorectal, head/neck, kidney, liver, lung, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)--------------------------------------------------------------------------------------non-Hodgkin’s lymphoma Phase II

(650) 225-1000

AZD4877 AstraZeneca (see also leukemia) Phase IWilmington, DE (800) 236-9933

bectumomab Immunomedics non-Hodgkin’s lymphoma Phase IIMorris Plains, NJ imaging agent (973) 605-8200

belinostat TopoTarget USA peripheral T-cell lymphoma Phase IIIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

leukemia, liver, lung, ovarian)--------------------------------------------------------------------------------------cutaneous T-cell lymphoma, Phase IInon-Hodgkin’s lymphoma, (973) 895-6900thymoma

Bexxar® GlaxoSmithKline (see also leukemia, cancer-related) Phase IItositumomab Rsch. Triangle Park, NC (888) 825-5249

BI 2536 Boehringer Ingelheim non-Hodgkin’s lymphoma Phase IPharmaceuticals (800) 243-0127Ridgefield, CT

BiovaxID™ Accentia non-Hodgkin’s lymphoma Phase IIIB-cell lymphoma BioPharmaceuticals (813) 864-2554vaccine Tampa, FL

CAL-101 Calistoga Pharmaceuticals non-Hodgkin’s lymphoma Phase ISeattle, WA (see also leukemia) (206) 728-4700

CAT-8015 MedImmune non-Hodgkin’s lymphoma Phase IGaithersburg, MD (see also leukemia) (301) 398-0000

cilengitide EMD Serono late-stage lymphoma Phase IRockland, MA (see also brain, prostate, (800) 283-8088

solid tumors)



Clearazide™ Yaupon Therapeutics cutaneous T-cell lymphoma Phase IIIRadnor, PA (610) 975-9290

Clolar® Genzyme B-cell lymphoma, Phase I/IIclofarabine Cambridge, MA non-Hodgkin’s lymphoma (617) 252-7500

(see also leukemia)

crinobulin EpiCept (see also solid tumors) Phase ITarrytown, NY (914) 606-3500

CT-011 CureTech B-cell lymphoma Phase IIYavne, Israel www.curetechbio.com

dacetuzumab Genentech diffuse large B-cell lymphoma Phase II(anti-CD40) South San Francisco, CA (see also leukemia, (650) 225-1000

Seattle Genetics multiple myeloma) (425) 527-4000Bothell, WA --------------------------------------------------------------------------------------

non-Hodgkin’s lymphoma Phase I(650) 225-1000(425) 527-4000

denenicokin ZymoGenetics non-Hodgkin’s lymphoma Phase I(IL-21) Seattle, WA (combination therapy) (206) 442-6600

(see also colorectal, kidney, ovarian, skin)

DI-Leu16-IL2 EMD Serono non-Hodgkin’s lymphoma Phase IRockland, MA (800) 283-8088Provenance (781) 491-9888BiopharmaceuticalsWaltham, MA

elsamitrucin Spectrum non-Hodgkin’s lymphoma Phase II completedPharmaceuticals (949) 788-6700Irvine, CA

enzastaurin Eli Lilly non-Hodgkin’s lymphoma Phase III(LY317615) Indianapolis, IN (see also brain, breast, colorectal, (800) 545-5979

multiple myeloma, ovarian, prostate)

EZN-2968 Enzon Pharmaceuticals (see also solid tumors) Phase IBridgewater, NJ (866) 792-5172

Fodosine™ BioCryst Pharmaceuticals cutaneous T-cell lymphoma Phase IIIforodesine Birmingham, AL (see also leukemia) (205) 444-4600

--------------------------------------------------------------------------------------T-cell lymphoma Phase II

(205) 444-4600

fostamatinib Rigel Pharmaceuticals B-cell lymphoma, Phase IISouth San Francisco, CA T-cell lymphoma (650) 624-1100

GA101 Biogen Idec B-cell lymphoma, Phase IICambridge, MA non-Hodgkin’s lymphoma (617) 679-2000Genentech (650) 225-1000South San Francisco, CA

galiximab Biogen Idec non-Hodgkin’s lymphoma Phase III(anti-CD80 mAb) Cambridge, MA (617) 679-2000



GCS-100 Prospect Therapeutics diffuse large B-cell lymphoma Phase I/IIWoburn, MA (combination therapy) (781) 939-5750

(see also leukemia, multiple myeloma)

Gemzar® Eli Lilly (see also head/neck, lung, sarcoma) Phase IIgemcitabine Indianapolis, IN (800) 545-5979

Genasense® Genta non-Hodgkin’s lymphoma Phase IIoblimersen Berkeley Heights, NJ (see also breast, leukemia, lung, (908) 286-9800

skin, solid tumors)

GMX-1777 Gemin X Biotechnologies (see also skin, solid tumors) Phase IMontreal, Canada (514) 281-8989

GS-9219 Gilead Sciences non-Hodgkin’s lymphoma Phase I/IIFoster City, CA (see also leukemia) (800) 445-3235

Hycamtin® GlaxoSmithKline non-Hodgkin’s lymphoma Phase IItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, leukemia, lung, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

iboctadekin GlaxoSmithKline non-Hodgkin’s lymphoma Phase IRsch. Triangle Park, NC (combination therapy) (888) 825-5249

(see also ovarian)

Idamycin® Pfizer non-Hodgkin’s lymphoma Phase IIIidarubicin New York, NY (see also multiple myeloma) (860) 732-5156

inotuzumab UCB non-Hodgkin’s lymphoma, Phase IIIozogamicin Smyrna, GA (combination therapy) (770) 970-7500

Wyeth Pharmaceuticals (800) 934-5556Collegeville, PA

iratumumab Medarex Hodgkin’s disease, lymphoma, Phase II(MDX-060) Princeton, NJ non-Hodgkin’s lymphoma (609) 430-2880(Orphan Drug)IT-101 Calando Pharmaceuticals (see also ovarian) Phase II

Pasadena, CA (626) 683-7200

Leukine® Bayer HealthCare non-Hodgkin’s lymphoma Phase IIsargramostim Pharmaceuticals (see also leukemia, ovarian, (888) 842-2937

Wayne, NJ prostate, skin)

lucatumumab Novartis Pharmaceuticals (see also multiple myeloma) Phase I/IIEast Hanover, NJ (888) 669-6682XOMA (510) 204-7200Berkeley, CA

LY2469298 Eli Lilly Phase IIndianapolis, IN (800) 545-5979

LymphoCide® Immunomedics non-Hodgkin’s lymphoma Phase IIepratuzumab Morris Plains, NJ (see also leukemia) (973) 605-8200(Orphan Drug)MDX-1401 Medarex Hodgkin’s disease Phase I

Princeton, NJ (609) 430-2880



MGCD-0103 MethylGene B-cell lymphoma, Phase IIMontreal, Canada Hodgkin’s disease, (514) 337-3333

non-Hodgkin’s lymphoma(see also leukemia, solid tumors)

milatuzumab Immunomedics non-Hodgkin’s lymphoma Phase I/II(IMMU-115) Morris Plains, NJ (see also leukemia, multiple (973) 605-8200

myeloma)

MLN8237 Millennium non-Hodgkin’s lymphoma Phase IIPharmaceuticals (see also brain, leukemia, (800) 390-5663Cambridge, MA solid tumors)

Nipent® Hospira cutaneous T-cell lymphoma application submittedpentostatin Lake Forest, IL (see also leukemia, cancer-related) (224) 212-2000(Orphan Drug) --------------------------------------------------------------------------------------

non-Hodgkin’s lymphoma Phase II(224) 212-2000

NPI-0052 Nereus Pharmaceuticals (see also multiple myeloma, Phase ISan Diego, CA solid tumors) (858) 587-4090

NPI-2358 Nereus Pharmaceuticals (see also lung) Phase ISan Diego, CA (858) 587-4090

obatoclax Gemin X Biotechnologies follicular lymphoma, Phase IIMontreal, Canada Hodgkin’s disease (514) 281-8989

(see also leukemia, lung)--------------------------------------------------------------------------------------mantle-cell lymphoma Phase I(combination therapy) (514) 281-8989

ofatumumab GlaxoSmithKline non-Hodgkin’s lymphoma Phase IIIRsch. Triangle Park, NC (second-line therapy) (888) 825-5249

(see also leukemia)--------------------------------------------------------------------------------------non-Hodgkin’s lymphoma Phase II(first-line therapy), Waldenström’s (888) 825-5249macroglobulinemia

Oncaspar® Enzon Pharmaceuticals combination therapy Phase Ipegaspargase Bridgewater, NJ (see also solid tumors) (866) 792-5172

ortatexal Spectrum Pharmaceuticals non-Hodgkin’s lymphoma Phase IIIrvine, CA (see also kidney) (949) 788-6700

P276 Piramal Life Sciences mantle-cell lymphoma Phase IIMumbai, India (see also multiple myeloma)

panobinostat Novartis Pharmaceuticals cutaneous T-cell lymphoma Phase II/IIIEast Hanover, NJ (see also brain, breast, leukemia, (888) 669-6682

prostate)--------------------------------------------------------------------------------------Hodgkin’s disease Phase II

(888) 669-6682

PCI-32765 Pharmacyclics B-cell lymphoma Phase ISunnyvale, CA (408) 774-0330



PD-332991 Pfizer mantle-cell lymphoma Phase INew York, NY (see also breast, multiple myeloma) (860) 732-5156

perifosine AEterna Zentaris Waldenström’s macroglobulinemia Phase IIMontreal, Canada (see also brain, head/neck, kidney, (212) 531-5965Keryx Biopharmaceuticals multiple myeloma, ovarian, New York, NY sarcoma)

pixantrone Cell Therapeutics non-Hodgkin’s lymphoma Phase IIISeattle, WA (800) 215-2355

PM-00104 PharmaMar USA (see also solid tumors) Phase ICambridge, MA (617) 868-3797

pralatrexate Allos Therapeutics B-cell lymphoma, Phase II(PDX) Westminster, CO peripheral T-cell lymphoma (303) 426-6262(Orphan Drug) (see also bladder, lung)

--------------------------------------------------------------------------------------Hodgkin’s disease, Phase I/IInon-Hodgkin’s lymphoma (303) 426-6262--------------------------------------------------------------------------------------cutaneous T-cell lymphoma Phase I

(303) 426-6262

PRO-131921 Genentech non-Hodgkin’s lymphoma Phase I/IISouth San Francisco, CA (see also leukemia) (650) 224-1000

PX-478 Oncothyreon (see also solid tumors) Phase ISeattle, WA (206) 801-2100

R1507 Roche Hodgkin’s disease, Phase INutley, NJ non-Hodgkin’s lymphoma (973) 235-5000

(see also breast, lung, sarcoma)

Revlimid® Celgene mantle-cell lymphoma, Phase IIlenalidomide Summit, NJ non-Hodgkin’s lymphoma (908) 673-9000

(see also leukemia, multiple myeloma, prostate, other)

RH-1 Allos Therapeutics non-Hodgkin’s lymphoma Phase IWestminster, CO (see also solid tumors) (303) 426-6262

romidepsin Gloucester Pharmaceuticals cutaneous T-cell lymphoma, Phase II(Orphan Drug) Cambridge, MA peripheral T-cell lymphoma (617) 583-1300

(see also kidney, multiple myeloma,pancreatic, prostate)

sapacitabine Cyclacel Pharmaceuticals cutaneous T-cell lymphoma Phase IIShort Hills, NJ (see also leukemia, lung) (973) 847-5955

SAR3419 sanofi-aventis non-Hodgkin’s lymphoma Phase IBridgewater, NJ (800) 633-1610

sardomozide Novartis Pharmaceuticals non-Hodgkin’s lymphoma Phase IIEast Hanover, NJ (see also solid tumors) (888) 669-6682

SB-1518 S*Bio (see also leukemia) Phase IRedwood City, CA (650) 730-2860

SCH-900776 Schering-Plough (see also solid tumors) Phase IKenilworth, NJ (908) 298-4000



SGN-30 Seattle Genetics cutaneous T-cell lymphoma, Phase II(Orphan Drug) Bothell, WA Hodgkin’s disease (425) 527-4000

SGN-35 Seattle Genetics Hodgkin’s disease Phase II(Orphan Drug) Bothell, WA (see also leukemia) (425) 527-4000

SNS-032 Sunesis Pharmaceuticals B-cell lymphoma Phase ISouth San Francisco, CA (see also solid tumors) (650) 266-3500

stem cell therapy Benitec AIDS-related lymphoma Phase IMelbourne, AustraliaCity of Hope Medical CenterDuarte, CA

TG-1042 Transgene cutaneous B-cell lymphoma Phase IIKensington, MD (301) 816-5404

TNX-650 Genentech refractory metastatic Hodgkin’s Phase I/IISouth San Francisco, CA disease (650) 225-1000

Torisel™ Wyeth Pharmaceuticals mantle-cell lymphoma Phase IIItemsirolimus Collegeville, PA (see also colorectal, kidney, lung, (800) 934-5556


UNBS-5162 Drais Pharmaceuticals (see also solid tumors) Phase IBridgewater, NJ (908) 895-1200

Velcade® Millennium non-Hodgkin’s lymphoma Phase IIIbortezomib Pharmaceuticals (see also lung, multiple myeloma, (800) 390-5663

Cambridge, MA solid tumors)

veltuzumab Immunomedics non-Hodgkin’s lymphoma Phase I/II(IMMU-106) Morris Plains, NJ (see also cancer-related) (973) 605-8200

Vidaza® Celgene (see also leukemia, prostate) Phase Iazacitidine Summit,NJ (908) 673-9000

vinorelbine Hana Biosciences non-Hodgkin’s lymphoma Phase Iliposomal South San Francisco, CA (see also solid tumors) (650) 588-6404

Xcytrin® Pharmacyclics lymphoma, non-Hodgkin’s lymphoma Phase IImotexafin Sunnyvale, CA (see also brain, kidney, leukemia, (408) 774-0330gadolinium lung)

XmAb 2513 Xencor Hodgkin’s disease, Phase IMonrovia, CA T-cell lymphoma (626) 305-5900

YM-155 Astellas Pharma US refractory, metastatic diffuse large Phase IIDeerfield, IL B-cell lymphoma (800) 727-7003

(see also prostate)

ZEN-012 AEterna Zentaris (see also solid tumors) Phase IWarren, NJ (908) 626-5428

Zevalin® Spectrum Pharmaceuticals non-Hodgkin’s lymphoma application submittedibritumomab Irvine, CA (first-line therapy) (949) 788-6700tiuxetan

Zolinza® Merck B-cell lymphoma, lymphoma Phase IIvorinostat Whitehouse Station, NJ (see also brain, breast, colorectal, (800) 672-6372

kidney, leukemia, lung, multiple myeloma)


M U L T I P L E M Y E L O M AProduct Name Sponsor Indication Development Status

Actimid™ Celgene (see also lung, pancreatic, prostate, Phase I/IIpomalidomide Summit, NJ sarcoma) (908) 673-9000

Amplimexon® AmpliMed (see also breast, lung, pancreatic, Phase I/II completedimexon Tucson, AZ prostate, skin) (520) 529-1000

anti-MUC1 mAb Paladin Labs (see also breast, pancreatic) Phase I completedSt. Laurent, Canada (888) 376-7830

Aredia® Novartis Pharmaceuticals (see also cancer-related) Phase IIpamidronic acid East Hanover, NJ (888) 669-6682

atacicept EMD Serono (see also leukemia, lymphoma) Phase II(TACI-Ig) Rockland, MA (800) 283-8088

ZymoGenetics (206) 442-6600Seattle, WA

ATN-224 Attenuon (see also prostate, skin) Phase I/IISan Diego, CA (858) 558-4111

AUY922 Novartis Pharmaceuticals (see also solid tumors) Phase I/IIEast Hanover, NJ (888) 669-6682

Avastin® Genentech combination therapy Phase IIbevacizumab South San Francisco, CA (see also brain, colorectal, (650) 225-1000

head/neck, kidney, liver, lung, lymphoma, ovarian, pancreatic, prostate, stomach, other)

AZD6244 AstraZeneca (see also leukemia, liver, lung, Phase IIWilmington, DE ovarian, pancreatic, skin, other) (800) 236-9933

BIW 8962 BioWa Phase I/IIPrinceton, NJ (609) 734-3420

carfilzomib Proteolix monotherapy Phase II(Orphan Drug) South San Francisco, CA (see also leukemia, solid tumors) (650) 615-7550

--------------------------------------------------------------------------------------combination therapy Phase I

(650) 615-7550

CEP-18770 Cephalon Phase IFrazer, PA (610) 344-0200

CP-751871 Pfizer (see also breast, colorectal, lung, Phase I completedNew York, NY prostate, sarcoma) (860) 732-5156

CX-4945 Cylene Pharmaceuticals (see also solid tumors, other) Phase ISan Diego, CA (858) 875-5100

dacetuzumab Genentech (see also leukemia, lymphoma) Phase I(anti-CD40) South San Francisco, CA (650) 225-1000(Orphan Drug) Seattle Genetics (425) 527-4000

Bothell, WA

darinaparsin Ziopharm Oncology (see also leukemia, liver, Phase II(ZIO-101) New York, NY solid tumors) (646) 214-0700

denosumab Amgen (see also cancer-related, other) Phase III(AMG 162) Thousand Oaks, CA (805) 447-1000



elotuzumab Bristol-Myers Squibb Phase IPrinceton, NJ (212) 546-4000Facet Biotech (650) 454-1000Redwood City, CA

ENMD-2076 EntreMed (see also solid tumors) Phase IRockville, MD (240) 864-2600

enzastaurin Eli Lilly (see also brain, breast, colorectal, Phase II(LY317615) Indianapolis, IN lymphoma, ovarian, prostate) (800) 545-5979

GCS-100 Prospect Therapeutics (see also leukemia, lymphoma) Phase IWoburn, MA (781) 939-5750

GRN-163L Geron (see also breast, leukemia, lung) Phase IMenlo Park, CA (650) 473-7700

Hycamtin® GlaxoSmithKline (see also breast, colorectal, in clinical trialstopotecan Rsch. Triangle Park, NC head/neck, kidney, leukemia, lung, (888) 825-5249

lymphoma, ovarian, pancreatic, prostate, stomach, other)

Idamycin® Pfizer (see also lymphoma) Phase IIIidarubicin New York, NY (860) 732-5156

IMGN-901 ImmunoGen (see also lung) Phase ICambridge, MA (617) 995-2500

INCB-18424 Incyte (see also prostate) Phase IIWilmington, DE (302) 498-6700

IPH-2101 Innate Pharma Phase IMarseille, France www.innate-pharma.com

KRX-0402 Keryx Biopharmaceuticals (see also brain, colorectal, kidney, Phase IINew York, NY sarcoma) (212) 531-5965

lestaurtinib Cephalon (see also leukemia) Phase IIFrazer, PA (610) 344-0200

lucatumumab Novartis Pharmaceuticals (see also lymphoma) Phase IEast Hanover, NJ (888) 669-6682XOMA (510) 204-7200Berkeley, CA

LY2127399 Eli Lilly Phase IIIndianapolis, IN (800) 545-5979

mapatumumab Human Genome Sciences (see also liver, lung) Phase IIRockville, MD (301) 309-8504

milatuzumab Immunomedics (see also leukemia, lymphoma) Phase I/II(IMMU-115) Morris Plains, NJ (973) 605-8200

natalizumab Biogen Idec Phase I/IICambridge, MA (617) 679-2000

noscapine Cougar Biotechnology Phase I/IILos Angeles, CA (310) 943-8040

NPI-0052 Nereus Pharmaceuticals (see also lymphoma, solid tumors) Phase ISan Diego, CA (858) 587-4090



P276 Piramal Life Sciences (see also lymphoma) Phase IMumbai, India

PD-332991 Pfizer combination therapy Phase I/IINew York, NY (see also breast, lymphoma) (860) 732-5156

perifosine AEterna Zentaris (see also brain, head/neck, Phase IIMontreal, Canada kidney, lymphoma, ovarian, (212) 531-5965Keryx Biopharmaceuticals sarcoma)New York, NY

plitidepsin PharmaMar USA (see also lung, prostate) Phase II(Orphan Drug) Cambridge, MA (617) 868-3797

Quadramet® Cytogen (see also prostate, sarcoma, Phase I/IIsamarium sm-153 Princeton, NJ other) (800) 833-3533lexidronam injection

Revlimid® Celgene newly-diagnosed multiple myeloma Phase IIIlenalidomide Summit, NJ (see also leukemia, lymphoma, (908) 673-9000

prostate, other)

romidepsin Gloucester Pharmaceuticals (see also kidney, lymphoma, Phase IICambridge, MA pancreatic, prostate) (617) 583-1300

SF1126 Semafore Pharmaceuticals (see also solid tumors) Phase IIndianapolis, IN (317) 876-3075

tanespimycin Bristol-Myers Squibb (see also solid tumors) Phase III(Hsp90 inhibitor) Princeton, NJ (212) 546-4000

Torisel™ Wyeth Pharmaceuticals (see also colorectal, kidney, lung, Phase I/IItemsirolimus Collegeville, PA lymphoma, prostate) (800) 934-5556

Treanda® Cephalon Phase IIbendamustine Frazer, PA (610) 344-0200

Trisenox® Cephalon combination therapy Phase IIarsenic trioxide Frazer, PA (see also brain, leukemia) (610) 344-0200

VEL-0230 Velcura Therapeutics Phase I completedAnn Arbor, MI (734) 973-1000

Velcade® Millennium previously untreated multiple Phase IIIbortezomib Pharmaceuticals myeloma (800) 390-5663(subcutaneous) Cambridge, MA (see also lung, lymphoma, solid

tumors)

Zolinza® Merck (see also brain, breast, colorectal, Phase IIIvorinostat Whitehouse Station, NJ kidney, leukemia, lung, lymphoma) (800) 672-6372

ZRx101 ZelleRx (see also kidney, skin, Phase IChicago, IL cancer-related) (312) 243-5200

O V A R I A N C A N C E RProduct Name Sponsor Indication Development Status°A6 Angstrom Pharmaceuticals (see also other) Phase II

Solana Beach, CA (858) 314-2356


O V A R I A N C A N C E RProduct Name Sponsor Indication Development Status

abagovomab Menarini Phase II/III(anti-idiotype Florence, Italy www.menarini.comovarian cancer vaccine)

Abraxane™ Abraxis BioScience (see also head/neck, lung, Phase IIalbumin-bound Los Angeles, CA pancreatic, prostate, skin) (310) 883-1300paclitaxel

Advexin® Introgen Therapeutics (see also bladder, brain, breast, Phase Icontusugene Austin, TX head/neck, lung, prostate, stomach) (512) 708-9310ladenovec

AE-37 Antigen Express combination therapy Phase IWorcester, MA (see also breast) (508) 852-8783

AG-14699 Pfizer (see also breast) Phase IINew York, NY (860) 732-5156

AGS-8M4 Agensys Phase ISanta Monica, CA (310) 820-8029Astellas Pharma US (800) 477-6472Deerfield, IL

Alimta® Eli Lilly (see also breast, head/neck, lung) Phase IIpemetrexed Indianapolis, IN (800) 545-5979

AMG 386 Amgen (see also breast, kidney, Phase IIThousand Oaks, CA stomach, other) (805) 447-1000

ANZ-207 Anza Therapeutics (see also lung, pancreatic) Phase IConcord, CA (925) 288-6000

Armala™ GlaxoSmithKline (see also brain, breast, cervical, Phase IIpazopanib Rsch. Triangle Park, NC kidney, liver, lung, sarcoma, other) (888) 825-5249

Avastin® Genentech (see also brain, colorectal, Phase IIIbevacizumab South San Francisco, CA head/neck, kidney, liver, lung, (650) 225-1000

lymphoma, multiple myeloma, pancreatic, prostate, stomach, other)

AZD2281 AstraZeneca (see also breast) Phase IIWilmington, DE (800) 236-9933

AZD6244 AstraZeneca (see also leukemia, liver, lung, Phase IIWilmington, DE multiple myeloma, pancreatic, skin, (800) 236-9933

other)

belinostat TopoTarget USA (see also bladder, colorectal, leukemia, Phase IIRockaway, NJ liver, lung, lymphoma) (973) 895-6900

BMS-753493 Bristol-Myers Squibb in clinical trials(epothilone-folate) Princeton, NJ (212) 546-4000

BSI-201 BiPar Sciences combination and monotherapy Phase IIBrisbane, CA (see also brain, breast, other) (650) 635-6050

catumaxomab Fresenius Biotech (see also other) Phase IINorth America www.fresenius-biotech.comWaltham, MA

CDX-1307 Celldex Therapeutics (see also bladder, breast, colorectal, Phase INeedham, MA pancreatic) (781) 433-0771



D4064A Genentech (see also other) Phase ISouth San Francisco, CA (650) 224-1000

DCVax®-L Northwest Biotherapeutics Phase I/IIovarian cancer Bothell, WA (425) 608-3000vaccine

denenicokin ZymoGenetics (see also colorectal, kidney, Phase I/II(IL-21) Seattle, WA lymphoma, skin) (206) 442-6600

EC-145 Endocyte (see also lung, other) Phase IIWest Lafayette, IN (765) 463-7175

EGEN 001 Expression Genetics recurrent ovarian cancer Phase I(Orphan Drug) Huntsville, AL (combination therapy) (256) 512-0077

Elacyt™ Clavis Pharma (see also leukemia, skin) Phase IIelacytarabine Oslo, Norway www.clavispharma.com

enzastaurin Eli Lilly combination therapy Phase II(LY317615) Indianapolis, IN (see also brain, breast, colorectal, (800) 545-5979

lymphoma, multiple myeloma, prostate)

eribulin mesylate Eisai (see also breast, head/neck, lung, Phase II(E7389) Woodcliff Lake, NJ prostate, sarcoma, solid tumors) (888) 422-4743

farletuzumab Eisai Phase II/III(MORAb-003) Woodcliff Lake, NJ (888) 422-4743

Herceptin® Genentech (see also colorectal, pancreatic, Phase IItrastuzumab South San Francisco, CA prostate, stomach, other) (650) 225-1000

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IIItopotecan Rsch. Triangle Park, NC head/neck, kidney, leukemia, lung, (888) 825-5249(oral) lymphoma, multiple myeloma,

pancreatic, prostate, stomach, other)

iboctadekin GlaxoSmithKline combination therapy Phase IRsch. Triangle Park, NC (see also lymphoma) (888) 825-5249

idronoxil Marshall Edwards combination therapy Phase IIINorth Ryde, Australia (see also prostate, other)

IMC-1121B Eli Lilly (see also breast, colorectal, kidney, Phase IIIndianapolis, IN liver, lung, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMT-1012 ImmunoVaccine (see also breast) Phase ITechnologies (902) 492-1819Halifax, Canada

IT-101 Calando Pharmaceuticals (see also lymphoma) Phase IIPasadena, CA (626) 683-7200

Karenitecin® BioNumerik (see also brain, lung, skin) Phase IIIcositecan Pharmaceuticals (210) 614-1701

San Antonio, TX

lapuleucel-T Dendreon (see also breast, colorectal) Phase I completedSeattle, WA (206) 256-4545



Leukine® Bayer HealthCare (see also leukemia, lymphoma, Phase IIsargramostim Pharmaceuticals prostate, skin) (888) 842-2937

Wayne, NJ

MK-4827 Merck Phase IWhitehouse Station, NJ (800) 672-6372

MORAb-009 Eisai (see also lung, pancreatic) Phase IWoodcliff Lake, NJ (888) 422-4743

NKTR-102 Nektar Therapeutics metastatic ovarian cancer Phase IISan Carlos, CA (second-line therapy) (650) 631-3100

(see also colorectal)

NOV-002 Novelos Therapeutics combination therapy Phase II completedNewton, MA (see also breast, lung) (617) 244-1616

oglufanide Implicit Bioscience Phase IIWoodside, CA (650) 851-3133

OGX-427 Oncogenex (see also bladder, breast, lung, Phase IPharmaceuticals prostate) (425) 686-1500Bothell, WA

Opaxio™ Cell Therapeutics (see also lung, stomach, other) Phase IIIpaclitaxel Seattle, WA (800) 215-2355poliglumex Novartis Pharmaceuticals (888) 669-6682

East Hanover, NJ

OvaRex® Paladin Labs Phase IIIoregovomab St. Laurent, Canada (514) 340-1112

OVax® AVAX Technologies Phase I/IIovarian cancer Philadelphia, PA (215) 241-9760vaccine(Orphan Drug)patupilone Novartis Pharmaceuticals (see also brain, breast, colorectal, Phase III(EPO906) East Hanover, NJ liver, lung) (888) 669-6682

perifosine AEterna Zentaris (see also brain, head/neck, kidney, Phase IMontreal, Canada lymphoma, multiple myeloma, (212) 531-5965Keryx Biopharmaceuticals sarcoma)New York, NY

pertuzumab Genentech (see also breast) Phase II completedSouth San Francisco, CA (650) 225-1000

plevitrexed BTG International Phase II(BGC 9331) West Conshohocken, PA (610) 278-1660(Orphan Drug)Quinamed® ChemGenex (see also breast, prostate) Phase IIamonafide Pharmaceuticals (650) 474-9800

Menlo Park, CA

sagopilone Bayer HealthCare combination therapy Phase I/IIPharmaceuticals (see also brain, breast, prostate) (888) 842-2937Wayne, NJ

SNS-595 Sunesis Pharmaceuticals (see also leukemia) Phase IISouth San Francisco, CA (650) 266-3500



systemic hedgehog Genentech (see also brain, colorectal, skin) Phase IIantagonist South San Francisco, CA (650) 224-1000

tasisulam (ASAP) Eli Lilly (see also leukemia, sarcoma, skin) Phase IIIndianapolis, IN (800) 545-5979

Telcyta™ Telik (see also breast, colorectal, lung) Phase IIIcanfosfimide Palo Alto, CA (650) 845-7700

topotecan Hana Biosciences (see also lung) Phase Iliposomal South San Francisco, CA (650) 588-6404

tucotuzumab EMD Serono (see also colorectal, lung, prostate) Phase IIcelmoleukin Rockland, MA (800) 283-8088

volociximab Biogen Idec (see also lung, pancreatic, skin) Phase IICambridge, MA (617) 679-2000Facet Biotech (650) 454-1000Redwood City, CA

Yondelis® Johnson & Johnson combination therapy, application submittedtrabectedin Pharmaceutical Research second-line therapy (800) 817-5286(Orphan Drug) & Development (see also breast, prostate, sarcoma,

Raritan, NJ other)

Zybrestat™ OXiGENE (see also head/neck, lung, other) Phase IIfosbretabulin Waltham, MA (781) 547-5900(Orphan Drug)ZYC300 Eisai (see also breast, colorectal, kidney, Phase I

Woodcliff Lake, NJ prostate) (888) 422-4743

P A N C R E A T I C C A N C E RProduct Name Sponsor Indication Development Status

Abraxane™ Abraxis BioScience (see also head/neck, lung, Phase I/IIalbumin-bound Los Angeles, CA ovarian, prostate, skin) (310) 883-1300paclitaxel

Actimid™ Celgene combination therapy Phase I/IIpomalidomide Summit, NJ (see also lung, multiple myeloma, (908) 673-9000

prostate, sarcoma)

aflibercept sanofi-aventis first-line metastatic Phase III(VEGF-trap) Bridgewater, NJ pancreatic cancer (800) 633-1810

Regeneron Pharmaceuticals (combination therapy) (914) 345-7400Tarrytown, NY (see also colorectal, lung,

prostate, other)

AMG 479 Amgen (see also breast, colorectal, lung, Phase I/IIThousand Oaks, CA sarcoma) (805) 447-1000

Amplimexon® AmpliMed (see also breast, lung, multiple Phase IIimexon Tucson, AZ myeloma, prostate, skin) (520) 529-1000

anti-MUC1 mAb Paladin Labs (see also breast, multiple myeloma) Phase I completedSt. Laurent, Canada (888) 376-7830



ANZ-207 Anza Therapeutics (see also lung, ovarian) Phase IConcord, CA (925) 288-6000

ARQ-197 ArQule (see also liver, lung, solid tumors) Phase I/IIWoburn, MA (781) 994-0300Daiichi Sankyo (973) 359-2600Parsippany, NJ

ARQ-501 ArQule combination therapy, inoperable/ Phase II(beta lapachone) Woburn, MA unresectable pancreatic cancer (781) 994-0300

(see also head/neck, solid tumors, other)

Avastin® Genentech combination first-line therapy Phase IIIbevacizumab South San Francisco, CA (see also brain, colorectal, (650) 225-1000

head/neck, kidney, liver, lung, lymphoma, multiple myeloma, ovarian, prostate, stomach, other)--------------------------------------------------------------------------------------pancreatic cancer Phase II

(650) 225-1000

AVN-944 Avalon Pharmaceuticals combination therapy Phase IIGermantown, MD (see also leukemia) (301) 556-9900

AZD6244 AstraZeneca (see also leukemia, liver, lung, Phase IIWilmington, DE multiple myeloma, ovarian, (800) 236-9933

skin, other)

Camptosar® Pfizer (see also cervical, lung, prostate) Phase IIIirinotecan New York, NY (860) 732-5156

Capoxigem® Tragara Pharmaceuticals combination therapy Phase IIapricoxib San Diego, CA (see also breast, lung) (858) 350-6900

CDX-1307 Celldex Therapeutics (see also bladder, breast, Phase INeedham, MA colorectal, ovarian) (781) 433-0771

conatumumab Amgen (see also colorectal, lung, sarcoma) Phase I/IIThousand Oaks, CA (805) 447-1000

everolimus Novartis Pharmaceuticals (see also kidney, other) Phase IIEast Hanover, NJ (888) 669-6682

FG-3019 Fibrogen combination therapy Phase ISan Francisco, CA (415) 978-1200

GI-4000 GlobeImmune combination therapy Phase IILouisville, CO (see also lung) (303) 625-2700

glufosfamide Threshold Pharmaceuticals (see also breast, lung, sarcoma) Phase III(Orphan Drug) Redwood City, CA (650) 474-8200

Herceptin® Genentech (see also colorectal, ovarian, Phase IItrastuzumab South San Francisco, CA prostate, stomach, other) (650) 225-1000

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IItopotecan Rsch. Triangle Park, NC head/neck, kidney, leukemia, lung, (888) 825-5249

lymphoma, multiple myeloma, ovarian, prostate, stomach, other)



HyperAcute® NewLink Genetics Phase IIPancreas Ames, IA (515) 296-5555pancreatric cancer vaccine

IMC-A12 Eli Lilly first-line combination therapy Phase I/IIIndianapolis, IN (see also breast, colorectal, (800) 545-5979ImClone Systems head/neck, liver, lung, prostate, (212) 645-1405New York, NY sarcoma, solid tumors)

Ixempra™ Bristol-Myers Squibb (see also breast, lung, prostate) in clinical trialsixabepilone Princeton, NJ (212) 546-4000

larotaxel sanofi-aventis (see also bladder) Phase III(XRP9881) Bridgewater, NJ (800) 633-1610

masitinib AB Science USA (see also leukemia, stomach) Phase IIIShort Hills, NJ (973) 218-2437

MK-0646 Merck (see also breast, lung, other) Phase I/IIWhitehouse Station, NJ (888) 669-6682

MKC 1 EntreMed (see also breast, leukemia, lung) Phase IIRockville, MD (240) 864-2600

MORAb-009 Eisai (see also lung, ovarian) Phase IIWoodcliff Lake, NJ (888) 422-4743

naptumomab Active Biotech (see also kidney, lung) Phase I completedestafenatox Lund, Sweden www.activebiotech.com

OncoGel™ Protherics (see also brain, stomach) Phase IIBrentwood, TN (615) 327-1027

Oncophage® Antigenics (see also brain, colorectal, kidney, Phase I/IIvitespen New York, NY skin, stomach) (866) 805-8994

OncoVEX GM-CSF BioVex (see also skin) Phase IWoburn, MA (781) 376-4900

PancAtak™ Advantagene Phase Igene therapy Boston, MA (617) 916-5445

San Diego, CA (760) 943-8981

PN401 Wellstat Therapeutics (see also colorectal, stomach) Phase IIIGaithersburg, MD (240) 631-2500

PX-12 Oncothyreon (see also stomach, other) Phase IISeattle, WA (206) 801-2100

RAV-12 Raven Biotechnologies combination therapy Phase IISouth San Francisco, CA (see also other) (650) 624-2600

Rexin-G™ Epeius Biotechnologies recurrent, refractory metastatic Phase I/IItumor-targeted San Marino, CA pancreatic cancer (626) 441-6695gene therapy (see also breast, sarcoma)(Orphan Drug)romidepsin Gloucester (see also kidney, lymphoma, Phase I/II

Pharmaceuticals multiple myeloma, prostate) (617) 583-1300Cambridge, MA

RP-101 SciClone Pharmaceuticals Phase II(Orphan Drug) Foster City, CA (650) 358-3456



RTA-402 Reata Pharmaceuticals combination therapy Phase I/IIDallas, TX (see also leukemia) (972) 865-2200

salirasib Concordia Pharmaceuticals (see also lung) Phase I/II(Orphan Drug) Ft. Lauderdale, FL www.concordiapharma.com

Sarasar™ Schering-Plough (see also breast, leukemia) Phase IIlonafarnib Kenilworth, NJ (908) 298-4000

Sutent® Pfizer (see also breast, colorectal, liver, Phase IIIsunitinib New York, NY lung, prostate, sarcoma, stomach) (860) 732-5156

Thymitaq® YM BioSciences (see also colorectal, head/neck, Phase IInolatrexed Wayne, PA liver, lung, prostate) (610) 560-0600

tigatuzumab Daiichi Sankyo Phase IIParsippany, NJ (973) 359-2600

TNFerade™ GenVec (see also colorectal, head/neck, Phase IIIGaithersburg, MD skin, stomach) (240) 632-0740

TPI-287 Tapestry Pharmaceuticals (see also prostate) Phase IIBoulder, CO (303) 516-8500

Triapine® Vion Pharmaceuticals (see also leukemia, lung, prostate) Phase IINew Haven, CT (203) 498-4210

Virulizin® Lorus Therapeutics Phase IIIToronto, Canada (416) 798-1200

volociximab Biogen Idec (see also lung, ovarian, skin) Phase IICambridge, MA (617) 679-2000Facet Biotech (650) 454-1000Redwood City, CA

Y-90 hPAM4 Immunomedics metastatic pancreatic cancer Phase I/II(IMMU-107) Morris Plains, NJ (973) 605-8200(Orphan Drug)Zarnestra™ Johnson & Johnson (see also leukemia) Phase IIItipifarnib Pharmaceutical Research (800) 817-5286


P R O S T A T E C A N C E RProduct Name Sponsor Indication Development Status

ABI-008 Abraxis BioScience hormone-refractory prostate cancer Phase I/IILos Angeles, CA (see also breast) (310) 883-1300

abiraterone acetate Cougar Biotechnology combination therapy, Phase III(CB7630) Los Angeles, CA second-line therapy (310) 943-8040

ABR-215050 Active Biotech Phase IILund, Sweden www.activebiotech.com

Abraxane™ Abraxis BioScience (see also head/neck, lung, ovarian, Phase IIalbumin-bound Los Angeles, CA pancreatic, skin) (310) 883-1300paclitaxel



Acapodene® GTx prostatic intraepithelial neoplasia Phase IIItoremifene Memphis, TN (prevention) (901) 523-9700

(see also cancer-related)

Actimid™ Celgene (see also lung, multiple myeloma, Phase IIpomalidomide Summit, NJ pancreatic, sarcoma) (908) 673-9000

Advexin® Introgen Therapeutics (see also bladder, brain, breast, Phase Icontusugene Austin, TX head/neck, lung, ovarian, stomach) (512) 708-9310ladenovec

aflibercept sanofi-aventis first-line metastatic prostate Phase III(VEGF-trap) Bridgewater, NJ cancer (combination therapy) (800) 633-1610

Regeneron Pharmaceuticals (see also colorectal, lung, (714) 345-7400Tarrytown, NY pancreatic, other)

AGS-1C4D4 Agensys Phase I completedSanta Monica, CA (310) 820-8029Astellas Pharma US (800) 477-6472Deerfield, IL

Amplimexon® AmpliMed (see also breast, lung, multiple Phase Iimexon Tucson, AZ myeloma, pancreatic, skin) (520) 529-1000

anti-idiotype Onyvax Phase IIcancer vaccine London, England www.onyvax.com105AD7

AT-101 Ascenta Therapeutics (see also lung, lymphoma) Phase IISan Diego, CA (858) 436-1200

ATN-224 Attenuon (see also multiple myeloma, skin) Phase IISan Diego, CA (858) 558-4111

Avastin® Genentech (see also brain, colorectal, Phase IIIbevacizumab South San Francisco, CA head/neck, kidney, liver, lung, (650) 225-1000

lymphoma, multiple myeloma, ovarian, pancreatic, stomach, other)

Avodart® GlaxoSmithKline prostate cancer prevention, Phase IIIdutasteride Rsch. Triangle Park, NC prostatic intraepithelial neoplasia (888) 825-5249

AZD4054 AstraZeneca hormone-refractory, metastatic Phase IIIWilmington, DE prostate cancer (800) 236-9933

BMS-641988 Bristol-Myers Squibb Phase I(androgen receptor Princeton, NJ (212) 546-4000antagonist)

cabazitaxel sanofi-aventis Phase III(XRP6258) Bridgewater, NJ (800) 633-1610

Camptosar® Pfizer (see also cervical, lung, pancreatic) Phase IIirinotecan New York, NY (860) 732-5156

Celebrex® Pfizer (see also bladder) Phase IIcelecoxib New York, NY (860) 732-5156

cilengitide EMD Serono (see also brain, lymphoma, Phase IIRockland, MA solid tumors) (800) 283-8088

CNTO 95 Centocor (see also skin, solid tumors) Phase II completedHorsham, PA (610) 651-6000



CNTO 328 Centocor hormone-refractory prostate cancer Phase IIHorsham, PA (see also kidney) (610) 651-6000

CP-751871 Pfizer combination therapy Phase IINew York, NY (see also breast, colorectal, lung, (860) 732-5156

multiple myeloma, sarcoma)

CYT-500 Cytogen Phase IPrinceton, NJ (800) 833-3533

deforolimus ARIAD Pharmaceuticals (see also breast, lung, sarcoma, Phase II(MK-8669) Cambridge, MA other) (617) 494-0400

Merck (800) 672-6372Whitehouse Station, NJ

DMXAA Antisoma (see also lung) Phase II completedCambridge, MA (617) 225-0522Novartis Pharmaceuticals (888) 669-6682East Hanover, NJ

enzastaurin Eli Lilly (see also brain, breast, colorectal, Phase II(LY317615) Indianapolis, IN lymphoma, multiple myeloma, (800) 545-5979

ovarian)

Erbitux® Bristol-Myers Squibb (see also bladder, colorectal, Phase IIIcetuximab Princeton, NJ head/neck, lung, stomach) (212) 546-4000

Eli Lilly (800) 545-5979Indianapolis, IN (212) 645-1405ImClone SystemsNew York, NY

eribulin mesylate Eisai hormone-refractory prostate cancer, Phase II(E7389) Woodcliff Lake, NJ prostate cancer (888) 422-4743

(see also breast, head/neck, lung, ovarian, sarcoma, solid tumors)

Gleevec® Novartis Pharmaceuticals (see also leukemia) Phase II/IIIimatinib East Hanover, NJ (888) 669-6682

GRNVAC1 Argos Therapeutics (see also leukemia) Phase I/IIDurham, NC (919) 287-6300Geron (650) 473-7700Menlo Park, CA

GTx-758 GTx Phase IMemphis, TN (901) 523-9700

HE-3235 Hollis-Eden late-stage prostate cancer Phase I/IIPharmaceuticals (858) 587-9333San Diego, CA

Herceptin® Genentech (see also colorectal, ovarian, Phase IItrastuzumab South San Francisco, CA pancreatic, stomach, other) (650) 225-1000

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IItopotecan Rsch. Triangle Park, NC head/neck, kidney, leukemia, lung, (888) 825-5249(oral) lymphoma, multiple myeloma,

ovarian, pancreatic, stomach, other)



HyperAcute® NewLink Genetics Phase I/IIProstate Ames, IA (515) 296-5555prostate cancer vaccine

idronoxil Marshall Edwards (see also ovarian, other) Phase IINorth Ryde, Australia

IMC-1121B Eli Lilly (see also breast, colorectal, kidney, Phase IIIndianapolis, IN liver, lung, ovarian, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also breast, colorectal, Phase IIIndianapolis, IN head/neck, liver, lung, pancreatic, (800) 545-5979ImClone Systems sarcoma, solid tumors) (212) 645-1045New York, NY

INCB-18424 Incyte (see also multiple myeloma) Phase IIWilmington, DE (302) 498-6700

INSM-18 Insmed Phase I/II completedGlen Allen, VA (804) 565-3000

Ixempra™ Bristol-Myers Squibb (see also breast, lung, pancreatic) in clinical trialsixabepilone Princeton, NJ (212) 546-4000

JNJ-26854165 Johnson & Johnson (see also lung) Phase IPharmaceutical Research (800) 817-5286& DevelopmentRaritan, NJ

Leukine® Bayer HealthCare (see also leukemia, lymphoma, Phase IIsargramostim Pharmaceuticals ovarian, skin) (888) 842-2937

Wayne, NJ

Leupron Depot® Abbott Pharmaceuticals Phase IIIleuprorelin depot Abbott Park, IL (847) 937-6100(6-month formulation)

leuprorelin Enzon Pharmaceuticals Phase Iinhalation Bridgewater, NJ (908) 541-8600

Nektar Therapeutics (650) 631-3100San Carlos, CA

MCS110 Novartis Pharmaceuticals (see also other) Phase I/IIEast Hanover, NJ (888) 669-6682

MDV-3100 Medivation hormone-refractory prostate Phase I/IISan Francisco, CA cancer (415) 543-3470

mepacrine Cleveland BioLabs Phase IIBuffalo, NY (716) 849-6810

MER-104 Merrion Pharmaceuticals Phase I/IIWilmington, NC (910) 799-1847

MIP1072 Molecular Insight diagnosis of prostate cancer Phase IPharmaceuticals (617) 492-5554Cambridge, MA



MIP1095 Molecular Insight diagnosis of prostate cancer Phase IPharmaceuticals (617) 492-5554Cambridge, MA


MVA-BN®-PRO BN ImmunoTherapeutics Phase I/IIMountain View, CA (650) 681-4660

NBI-42902 Neurocrine Biosciences (see also breast, other) Phase ISan Diego, CA (858) 617-7600

NeuVax™ Apthera (see also breast) Phase I/IIE75 cancer Scottsdale, AZ (480) 882-8841vaccine

OGX-427 Oncogenex (see also bladder, breast, lung, Phase IPharmaceuticals ovarian) (425) 686-1500Bothell, WA

Oncolar® Novartis Pharmaceuticals Phase IIoctreotide East Hanover, NJ (888) 669-6682

ONY-105 Onyvax Phase II(cancer vaccine) London, England www.onyvax.com

ONY-P Onyvax Phase II(prostate cancer London, England www.onyvax.comvaccine)

ozarelix Spectrum Pharmaceuticals Phase I/IIIrvine, CA (949) 788-6700

panobinostat Novartis Pharmaceuticals (see also brain, breast, leukemia, Phase IIEast Hanover, NJ lymphoma) (888) 669-6682

plitidepsin PharmaMar USA (see also lung, multiple myeloma) Phase IICambridge, MA (617) 868-3797

polyphenon E Polyphenon Pharma prostatic intraepithelial neoplasia Phase IINew York, NY (see also bladder, leukemia) (212) 661-0578

Proscar® Merck prostate cancer prevention Phase IIIfinasteride Whitehouse Station, NJ (800) 672-6372

ProstAtak™ Advantagene Phase IIgene therapy Boston, MA (617) 916-5445

San Diego, CA (760) 943-8981

prostate cancer Novartis Pharmaceuticals Phase I/IIvaccine East Hanover, NJ (888) 669-6682

Prostvac®-VF BN ImmunoTherapeutics Phase IIprostate Mountain View, CA (650) 681-4660cancer vaccine

Provenge® Dendreon hormone-refractory, metastatic application submittedsipuleucel-T Seattle, WA prostate cancer (206) 256-4545

--------------------------------------------------------------------------------------non-metastatic androgen-dependent Phase IIIprostate cancer (206) 256-4545



PRX-302 Protox Therapeutics Phase IIVancouver, Canada (604) 688-0199

PSMA-ADC Progenics Pharmaceuticals Phase ITarrytown, NY (914) 789-2800

PSMA cancer Progenics Pharmaceuticals Phase Ivaccine Tarrytown, NY (914) 789-2800

Quadramet® Cytogen (see also multiple myeloma, Phase IIsamarium SM-153 Princeton, NJ sarcoma, other) (800) 833-3533lexidronam injection

Quinamed® ChemGenex (see also breast, ovarian) Phase IIamonafide Pharmaceuticals (650) 474-9800

Menlo Park, CA

Revlimid® Celgene (see also leukemia, lymphoma, Phase IIlenalidomide Summit, NJ multiple myeloma, other) (908) 673-4900

romidepsin Gloucester Pharmaceuticals (see also kidney, lymphoma, Phase II completedCambridge, MA multiple myeloma, pancreatic) (617) 583-1300

sagopilone Bayer HealthCare combination therapy Phase IIPharmaceuticals (see also brain, breast, ovarian) (888) 842-2937Wayne, NJ

satraplatin Spectrum hormone-refractory prostate cancer Phase IIIPharmaceuticals (combination therapy, (949) 788-6700Irvine, CA second-line therapy)

(see also breast, lung)

seocalcitol Cougar Biotechnology Phase I(CB1089) Los Angeles, CA (310) 943-8040

Sprycel™ Bristol-Myers Squibb (see also leukemia, solid tumors) in clinical trialsdasatinib Princeton, NJ (212) 546-4000

Sutent® Pfizer hormone-refractory metastatic Phase IIIsunitinib New York, NY prostate cancer (860) 732-5156

(see also breast, colorectal, liver, lung, pancreatic, sarcoma, stomach)--------------------------------------------------------------------------------------adjunctive treatment Phase II

(860) 732-5156

TAK683 Millennium Phase IPharmaceuticals (800) 390-5663Cambridge, MA

TAK700 Millennium Phase I/IIPharmaceuticals (800) 390-5663Cambridge, MA

tandutinib Millennium (see also brain) Phase II(MLN0518) Pharmaceuticals (800) 390-5663

Cambridge, MA

tesmilifene YM BioSciences (see also breast) Phase IIWayne, PA (610) 560-0600



TheraCIM™ YM Biosciences hormone-refractory prostate cancer Phase IInimotuzumab Wayne, PA (see also brain, breast, stomach) (610) 560-0600

Thymitaq® YM BioSciences (see also colorectal, head/neck, Phase IInolatrexed Wayne, PA liver, lung, pancreatic) (610) 560-0600

tigapotide Ambrilia Biopharma Phase IIVerdun, Canada (514) 751-2003

Torisel™ Wyeth Pharmaceuticals (see also colorectal, kidney, lung, Phase IItemsirolimus Collegeville, PA lymphoma, multiple myeloma) (800) 934-5556

TPI-287 Tapestry Pharmaceuticals hormone-refractory prostate cancer Phase IIBoulder, CO (see also pancreatic) (303) 516-8500

transgenic B Cosmo Bioscience Phase IIlymphocyte San Diego, CA (858) 823-0413immunotherapy/cancer vaccine

tremelimumab Pfizer high-risk prostate cancer Phase II completedNew York, NY (see also breast, colorectal, kidney, (860) 732-5156

lung, skin)--------------------------------------------------------------------------------------combination therapy Phase I

(860) 732-5156

Triapine® Vion Pharmaceuticals (see also leukemia, lung, pancreatic) Phase IINew Haven, CT (203) 498-4210

trilostane Genzyme (see also breast) Phase IICambridge, MA (617) 252-7500

tucotuzumab EMD Serono (see also colorectal, lung, ovarian) Phase IIcelmoleukin Rockland, MA (800) 283-8088

VDC2008 Bostwick Laboratories Phase I/IIGlen Allen, VA (804) 967-9225

Vidaza® Celgene (see also leukemia, lymphoma) Phase IIazacitidine Summit,NJ (908) 673-9000

VP101 Access Pharmaceuticals (see also brain, colorectal, leukemia) Phase IIDallas, TX (214) 905-5100

YM-155 Astellas Pharma US hormone-refractory prostate cancer Phase IIDeerfield, IL (see also lymphoma) (800) 727-7003

YMB2002 YM BioSciences Phase II(prostate cancer Wayne, PA (610) 560-0600vaccine)

Yondelis® Johnson & Johnson (see also breast, ovarian, Phase IItrabectedin Pharmaceutical Research sarcoma, other) (800) 817-5286


ZYC300 Eisai (see also breast, colorectal, kidney, Phase IWoodcliff Lake, NJ ovarian) (888) 422-4743


S A R C O M AProduct Name Sponsor Indication Development Status

Actimid™ Celgene (see also lung, multiple myeloma, Phase IIpomalidomide Summit, NJ pancreatic, prostate) (908) 673-9000

AMG 479 Amgen (see also breast, colorectal, lung, Phase IIThousand Oaks, CA pancreatic) (805) 447-1000

Armala™ GlaxoSmithKline (see also brain, breast, cervical, Phase IIIpazopanib Rsch. Triangle Park, NC kidney, liver, lung, ovarian, other) (888) 669-6682

AVE8062 sanofi-aventis Phase IIIBridgewater, NJ (800) 633-1610

brostallicin Cell Therapeutics soft tissue sarcoma Phase IISeattle, WA (see also solid tumors) (800) 215-2355

cancer vaccine MabVax Therapeutics (see also breast) Phase ISan Diego, CA (858) 259-9405

conatumumab Amgen (see also colorectal, lung, Phase I/IIThousand Oaks, CA pancreatic) (805) 447-1000

CP-751871 Pfizer (see also breast, colorectal, lung, Phase I/IINew York, NY multiple myeloma, prostate) (860) 732-5156

deforolimus ARIAD Pharmaceuticals oral formulation Phase III(MK-8669) Cambridge, MA (see also breast, lung, prostate, other) (617) 494-0400(Orphan Drug) Merck (800) 672-6372

Whitehouse Station, NJ --------------------------------------------------------------------------------------intravenous formulation Phase I/II

(617) 494-0400(800) 672-6372

eribulin mesylate Eisai (see also breast, head/neck, lung, Phase II(E7389) Woodcliff Lake, NJ ovarian, prostate, solid tumors) (877) 873-4724

Fusilev™ Spectrum Pharmaceuticals (see also colorectal) application submittedlevoleucovorin Irvine, CA (949) 788-6700for injection

Gemzar® Eli Lilly (see also head/neck, lung, Phase IIgemcitabine Indianapolis, IN lymphoma) (800) 545-5979

glufosfamide Threshold Pharmaceuticals (see also breast, lung, pancreatic) Phase IIRedwood City, CA (650) 474-8200

IMC-A12 Eli Lilly soft tissue sarcoma Phase IIIndianapolis, IN (see also breast, colorectal, (800) 545-5979ImClone Systems head/neck, liver, lung, pancreatic, (212) 645-1405New York, NY prostate, solid tumors)

Junovan™ IDM Pharma osteosarcoma application submittedmifamurtide Irvine, CA (949) 470-4751

KRX-0402 Keryx Biopharmaceuticals (see also brain, colorectal, kidney, Phase IINew York, NY multiple myeloma) (212) 531-5965

palifosfamide ZIOPHARM Oncology combination therapy Phase II(ZIO-201) New York, NY (see also solid tumors) (212) 214-0700(Orphan Drug) --------------------------------------------------------------------------------------

monotherapy Phase I/II(212) 214-0700


S A R C O M AProduct Name Sponsor Indication Development Status

perifosine AEterna Zentaris (see also brain, head/neck, Phase IIMontreal, Canada kidney, lymphoma, multiple (212) 531-5965Keryx Biopharmaceuticals myeloma, ovarian)New York, NY

Quadramet® Cytogen osteosarcoma Phase I/IIsamarium sm-153 Princeton, NJ (see also multiple myeloma, (800) 833-3533lexidronam prostate, other)injection

R1507 Roche (see also breast, lung, lymphoma) Phase IINutley, NJ (973) 235-5000

Reolysin® Oncolytics Biotech (see also brain, head/neck, lung, Phase IIreovirus Calgary, Canada skin) (403) 670-7377

Rexin-G™ Epeius Biotechnologies osteosarcoma Phase IItumor-targeted San Marino, CA (see also breast, pancreatic) (626) 441-6695gene therapy --------------------------------------------------------------------------------------

soft tissue sarcoma Phase I/II(626) 441-6695

robatumumab Schering-Plough osteosarcoma, sarcoma Phase IIKenilworth, NJ (see also colorectal) (908) 298-4000

Sutent® Pfizer soft tissue sarcoma Phase IIsunitinib New York, NY (see also breast, colorectal, liver, (860) 732-5156

lung, pancreatic, prostate, stomach)

tasisulam (ASAP) Eli Lilly soft tissue sarcoma Phase IIIndianapolis, IN (see also leukemia, ovarian, skin) (800) 545-5979

TH-302 Threshold soft tissue sarcoma Phase I/IIPharmaceuticals (see also solid tumors) (650) 474-8200Redwood City, CA

Yondelis® Johnson & Johnson first-line therapy Phase IIItrabectedin Pharmaceutical Research (see also breast, ovarian, prostate, (800) 817-5286(Orphan Drug) & Development other)

Raritan, NJ --------------------------------------------------------------------------------------in adolescents and children Phase II

(800) 817-5286

S K I N C A N C E RProduct Name Sponsor Indication Development Status

1203486A GlaxoSmithKline malignant melanoma Phase IIRsch. Triangle Park, NC (888) 825-5249

2132231A GlaxoSmithKline malignant melanoma Phase IIIRsch. Triangle Park, NC (888) 825-5249

Abraxane™ Abraxis BioScience malignant melanoma Phase IIalbumin-bound Los Angeles, CA (see also head/neck, lung, ovarian, (310) 883-1300paclitaxel pancreatic, prostate)

ABT-888 Abbott Laboratories malignant melanoma Phase IIAbbott Park, IL (see also solid tumors) (847) 937-6100



Allovectin-7® Vical metastatic melanoma Phase IIIvelimogene San Diego, CA (858) 646-1100aliplasmid(immunotherapeutic vaccine)(Orphan Drug)ALS-357 Advanced Life Sciences malignant melanoma Phase I(betulinic topical) Woodridge, IL (630) 739-6744

Amplimexon® AmpliMed malignant melanoma Phase I/II completedimexon Tucson, AZ (see also breast, lung, multiple (520) 529-1000

myeloma, pancreatic, prostate)

ATN-224 Attenuon malignant melanoma Phase IISan Diego, CA (see also multiple myeloma, prostate) (858) 720-8797

AZD6244 AstraZeneca malignant melanoma Phase IIWilmington, DE (see also leukemia, liver, lung, (800) 236-9933

multiple myeloma, ovarian, pancreatic, other)

Azixa™ Myriad Pharmaceuticals malignant melanoma Phase I/II(MPC-6827) Salt Lake City, UT (see also brain) (801) 584-3600

BMS-663513 Bristol-Myers Squibb second-line melanoma in clinical trials(anti-CD137 Princeton, NJ (212) 546-4000antibody)

Cadi 05 Cadila Pharmaceuticals malignant melanoma Phase I/IIBhat, India (see also solid tumors) www.cadilapharma.com

CNTO 95 Centocor malignant melonoma Phase I/IIHorsham, PA (see also prostate, solid tumors) (610) 651-6000

CR011-vcMMAE CuraGen malignant melanoma Phase IIBranford, CT (see also breast) (888) 436-6642

CYT-107 Cytheris malignant melanoma Phase I/IIRockville, MD (see also kidney, leukemia, (301) 231-0450

solid tumors)

denenicokin ZymoGenetics malignant melanoma Phase I/II(IL-21) Seattle, WA (see also colorectal, kidney, (206) 442-6600

lymphoma, ovarian)

Dimericine® AGI Dermatics Phase IIT4N5 liposome Freeport, NY (516) 868-9026lotion

dovitinib Novartis Pharmaceuticals malignant melanoma Phase I/IIEast Hanover, NJ (see also kidney) (888) 669-6682

ecromeximab Life Sciences malignant melanoma Phase IIPharmaceuticals (combination therapy) (203) 422-6500Greenwich, CT

Elacyt™ Clavis Pharma malignant melanoma (combination Phase IIelacytarabine Oslo, Norway therapy), malignant melanoma www.clavispharma.com

(first-line therapy)(see also leukemia, ovarian)



EMD 273063 EMD Serono malignant melanoma Phase IIRockland, MA (see also brain) (800) 283-8088

Exherin™ Adherex Technologies malignant melanoma Phase I/II(ADH-1) Durham, NC (see also solid tumors) (919) 484-8484

GC-1008 Genzyme malignant melanoma Phase ICambridge, MA (see also kidney) (617) 252-7000

Genasense® Genta malignant melanoma Phase IIIoblimersen Berkeley Heights, NJ (see also breast, leukemia, lung, (908) 286-9800(Orphan Drug) lymphoma, solid tumors)

GMX-1777 Gemin X Biotechnologies malignant melanoma Phase I/IIMontreal, Canada (combination therapy) (514) 281-8989

(see also lymphoma, solid tumors)

HyperAcute® NewLink Genetics malignant melanoma Phase I/IIMelanoma Ames, IA (515) 296-5555melanoma vaccine

IMC-1121B Eli Lilly metastatic malignant melanoma Phase IIIndianapolis, IN (see also breast, colorectal, kidney, (800) 545-5979ImClone Systems liver, lung, ovarian, prostate) (212) 645-1405New York, NY

INGN 241 Introgen Therapeutics malignant melanoma Phase II(mda-7) Austin, TX (see also head/neck) (512) 708-9310

interleukin-12 Inovio malignant melanoma Phase Igene therapy San Diego, CA (877) 446-6846

Karenitecin® BioNumerik malignant melanoma Phase II completedcositecan Pharmaceuticals (see also brain, lung, ovarian) (201) 614-1710

San Antonio, TX

Leukine® Bayer HealthCare malignant melanoma Phase IIsargramostim Pharmaceuticals (see also leukemia, lymphoma, (888) 842-2937

Wayne, NJ ovarian, prostate)

Lymphoseek™ Neoprobe diagnosis of malignant melanoma Phase IIIDublin, OH (see also breast) (800) 793-0079

Marqibo™ Hana Biosciences malignant melanoma Phase IIvincristine South San Francisco, CA (see also leukemia) (650) 588-6404liposomal(Orphan Drug)MDX-010 Bristol-Myers Squibb adjuvant melanoma, Phase III(ipilimumab) Princeton, NJ metastatic melanoma (212) 546-4000

Medarex (see also solid tumors)Princeton, NJ

melanoma Ichor Medical Systems malignant melanoma Phase Ivaccine San Diego, CA (858) 550-2022

melanoma Novavax malignant melanoma Phase Ivaccine Malvern, PA (484) 913-1200

melanoma sanofi-aventis treatment of stage III and Phase IIvaccine Bridgewater, NJ stage IV melanoma (800) 633-1610



Melaxin® Oncolix malignant melanoma Phase IIautologous Greenville, SCdendritoma vaccine

Metvixia® PhotoCure basal cell cancer Phase IIImethyl Oslo, Norway www.photocure.comaminolevulinate

MKC 1106-MT MannKind malignant melanoma Phase IValencia, CA (661) 775-5300

M-Vax® AVAX Technologies malignant melanoma Phase IIImelanoma Philadelphia, PA (215) 241-9760vaccine

Nexavar® Bayer HealthCare malignant melanoma Phase IIIsorafenib Pharmaceuticals (combination therapy) (888) 842-2837

Wayne, NJ (see also breast, lung) (510) 597-6500Onyx PharmaceuticalsEmeryville, CA

ODC-0501 ODC Therapy malignant melanoma Phase I/IIDallas, TX (214) 826-7019

Oncophage® Antigenics malignant melanoma Phase IIIvitespen New York, NY (see also brain, colorectal, kidney, (866) 805-8994

pancreatic, stomach)

OncoVAX® Vaccinogen malignant melanoma Phase I/IIcancer vaccine Frederick, MD (see also colorectal, kidney) (301) 668-8400

OncoVEX GM-CSF BioVex malignant melanoma Phase IIWoburn, MA (see also pancreatic) (781) 376-4900

PARP inhibitor Genentech malignant melanoma Phase ISouth San Francisco, CA (650) 225-1000

PEG-Intron A® Schering-Plough adjunctive treatment of stage III application submittedpeginterferon Kenilworth, NJ malignant melanoma (908) 298-4000alfa-2b (see also leukemia)

PEP-005 Peplin basal cell cancer Phase IIEmeryville, CA (510) 653-9700

PHP Curacyte malignant melanoma Phase IIChapel Hill, NC www.curacyte.com

PI-88 Progen Pharmaceuticals malignant melanoma Phase IIRedwood City, CA (650) 610-7080

PLX-4032 Plexxikon malignant melanoma Phase IBerkeley, CA (510) 647-4000Roche (973) 235-5000Nutley, NJ

PTC-299 PTC Therapeutics Kaposi’s sarcoma Phase I/IISouth Plainfield, CT (see also breast) (908) 222-7000

PV-10 Provectus Pharmaceuticals malignant melanoma Phase IIKnoxville, TN (866) 594-5999



RAF265 Novartis Pharmaceuticals malignant melanoma Phase IEast Hanover, NJ (888) 669-6682

Reolysin® Oncolytics Biotech malignant melanoma Phase IIreovirus Calgary, Canada (see also brain, head/neck, lung, (403) 670-7377

sarcoma)

systemic hedgehog Genentech basal cell cancer Phase IIantagonist South San Francisco, CA (see also brain, colorectal, ovarian) (650) 224-1000

tasisulam (ASAP) Eli Lilly malignant melanoma Phase IIIndianapolis, IN (see also leukemia, ovarian, sarcoma) (800) 545-5979

TM-601-I-131 TransMolecular metastatic malignant melanoma Phase I/IICambridge, MA (see also brain) (617) 995-3050

TNFerade™ GenVec malignant melanoma Phase IIGaithersburg, MD (see also colorectal, head/neck, (240) 632-0740

pancreatic, stomach)

tremelimumab Pfizer malignant melanoma Phase IINew York, NY (see also breast, colorectal, kidney, (860) 732-5156

lung, prostate)

VCL-IM01 Vical metastatic malignant melanoma Phase ISan Diego, CA (858) 646-1100

veglin VasGene Therapeutics Kaposi’s sarcoma Phase ILos Angeles, CA (323) 221-7818

Visudyne® QLT USA malignant melanoma Phase I/IIverteporfin Fort Collins, CO (800) 663-5486

volociximab Biogen Idec malignant melanoma Phase IICambridge, MA (see also lung, ovarian, pancreatic) (617) 679-2000Facet Biotech (650) 454-1000Redwood City, CA

Zadaxin® SciClone Pharmaceuticals malignant melanoma Phase IIthymalfasin Foster City, CA (650) 358-3456

ZRx101 ZelleRx malignant melanoma Phase IChicago, IL (see also kidney, multiple myeloma, (312) 243-5200

cancer-related)

S O L I D T U M O R SProduct Name Sponsor Indication Development Status

461364 GlaxoSmithKline (see also lymphoma) Phase IRsch. Triangle Park, NC (888) 825-5249

690693 GlaxoSmithKline (see also lymphoma) Phase IRsch. Triangle Park, NC (888) 825-5249

923295 GlaxoSmithKline refractory metastatic disease Phase IRsch. Triangle Park, NC (888) 825-5249

1MT NewLink Genetics Phase IAmes, IA (515) 296-5555



2DG Threshold Pharmaceuticals Phase I(2-deoxy-d-glucose) Redwood City, CA (605) 474-8200

ABI-009 Abraxis BioScience Phase ILos Angeles, CA (310) 883-1300

ABT-828 Abbott Laboratories Phase IAbbott Park, IL (847) 937-6100

ABT-888 Abbott Laboratories (see also skin) Phase IAbbott Park, IL (847) 937-6100

AEE788 Novartis Pharmaceuticals (see also brain) Phase IEast Hanover, NJ (888) 669-6682

AEW541 Novartis Pharmaceuticals (see also leukemia) Phase IEast Hanover, NJ (888) 669-6682

AFP-464 Tigris Pharmaceuticals Phase IBonita Springs, FL (239) 444-5400

AI-850 Acusphere Phase IWatertown, MA (617) 648-8800Cephalon (610) 344-0200Frazer, PA

ALB 109564(a) AMRI Phase IAlbany, NY (518) 512-2000

AMG 208 Amgen Phase IThousand Oaks, CA (805) 447-1000

AMG 888 Amgen Phase I(U3-1287) Thousand Oaks, CA (805) 447-1000

Daiichi Sankyo (973) 359-2600Parsippany, NJ

ANA-773 Anadys Pharmaceuticals Phase ISan Diego, CA (858) 530-3600

angiostatic Angiogen Phase Icocktail Evanston, IL (847) 866-6700

anti-EGFR Abbott Laboratories Phase ImAb-806 Abbott Park, IL (847) 937-6100

anti-IGF-1R mAb Genentech Phase ISouth San Francisco, CA (650) 225-1000

AR-67 Arno Therapeutics Phase IFairfield, NJ (862) 703-7170

ARQ-197 ArQule microphthalmia transcription Phase I/IIWoburn, MA factor tumors (781) 994-0300Daiichi Sankyo (see also liver, lung, pancreatic) (973) 359-2600Parsippany, NJ

ARQ-501 ArQule refractory metastatic solid tumors Phase I/II(beta lapachone) Woburn, MA (combination therapy) (781) 994-0300

(see also head/neck, pancreatic, other)

ARRY-520 Array BioPharma (see also leukemia) Phase IBoulder, CO (303) 381-6600



AT7519 Astex Therapeutics Phase ICambridge, United Kingdom

AT9283 Astex Therapeutics (see also leukemia) Phase ICambridge, United Kingdom

AT13387 Astex Therapeutics Phase ICambridge, United Kingdom

ATN-161 Attenuon Phase ISan Diego, CA (858) 720-8797

AUY922 Novartis Pharmaceuticals (see also multiple myeloma) Phase I/IIEast Hanover, NJ (888) 669-6682

AV-299 AVEO Pharmaceuticals advanced solid tumors Phase I(SCH-90015) Cambridge, MA (see also lymphoma) (617) 299-5000

Schering-PloughKenilworth, NJ

AV-412 AVEO Pharmaceuticals Phase ICambridge, MA (617) 299-5000

axitinib Pfizer combination therapy, Phase INew York, NY late-stage disease (860) 732-5156

(see also colorectal, kidney, lung, other)




AZD8055 AstraZeneca Phase I/IIWilmington, DE (800) 236-9933



AZM475271 AstraZeneca (see also leukemia) Phase IWilmington, DE (800) 236-9933

BEZ235 Novartis Pharmaceuticals Phase IEast Hanover, NJ (888) 669-6682

BGT226 Novartis Pharmaceuticals Phase I/IIEast Hanover, NJ (888) 669-6682

BHQ880 Novartis Pharmaceuticals Phase IEast Hanover, NJ (888) 669-6682

BI 6727 Boehringer Ingelheim Phase IPharmaceuticals (800) 243-0127Ridgefield, CT

BI 831266 Boehringer Ingelheim Phase IPharmaceuticals (800) 243-0127Ridgefield, CT



BIBF 1120 Boehringer Ingelheim combination therapy Phase IPharmaceuticals (see also lung) (800) 243-0127Ridgefield, CT

BIIB 015 Biogen Idec Phase ICambridge, MA (617) 679-2000

BIIB 022 Biogen Idec Phase ICambridge, MA (617) 679-2000

BMS-690514 Bristol-Myers Squibb (see also lung) in clinical trials(ErbB/VEGF Princeton, NJ (212) 546-4000receptor inhibitor)

BMS-754807 Bristol-Myers Squibb in clinical trials(IGF-1R antagonist) Princeton, NJ (212) 546-4000

BMS-833923 Bristol-Myers Squibb Phase I(SMO inhibitor) Princeton, NJ (212) 546-4000

ExelixisSouth San Francisco, CA

BMS-844203 Bristol-Myers Squibb (see also brain) in clinical trials(VEGF inhibitor- Princeton, NJ (212) 546-4000adnectin)

bosutinib Wyeth Pharmaceuticals (see also breast, leukemia) Phase ICollegeville, PA (800) 934-5556

BQS481 Novartis Pharmaceuticals Phase IEast Hanover, NJ (888) 669-6682

brostallicin Cell Therapeutics advanced solid tumors Phase IISeattle, WA (see also sarcoma) (800) 215-2355


(800) 215-2355

Cadi 05 Cadila Pharmaceuticals (see also skin) Phase IBhat, India www.cadilapharma.com

CALAA 01 Calando Pharmaceuticals Phase IPasadena, CA (626) 683-7200

carfilzomib Proteolix relapsed solid tumors Phase I/IISouth San Francisco, CA (see also leukemia, (650) 615-7550

multiple myeloma)

CBP501 Millennium (see also lung) Phase IPharmaceuticals (800) 390-5663Cambridge, MA

CDX-110 Celldex Therapeutics (see also brain) Phase INeedham, MA (781) 433-0771Pfizer (860) 732-5156New York, NY

CEP-11981 Cephalon Phase IFrazer, PA (610) 344-0200

cevipabulin Wyeth Pharmaceuticals Phase ICollegeville, PA (800) 934-5556



CG-201 CG Therapeutics Phase ISeattle, WA (206) 336-5604

cilengitide EMD Serono late-stage solid tumors Phase IRockland, MA (see also brain, lymphoma, prostate) (800) 283-8088

CNF-2024 Biogen Idec (see also breast, leukemia, stomach) Phase ICambridge, MA (617) 679-2000

CNTO 95 Centocor (see also prostate, skin) Phase I completedHorsham, PA (610) 651-6000

CNTO 888 Centocor Phase IHorsham, PA (610) 651-6000

CP-870893 Pfizer Phase INew York, NY (860) 732-5156

crinobulin EpiCept (see also lymphoma) Phase ITarrytown, NY (914) 606-3500

CRx-026 CombinatoRx late-stage, metastatic solid tumors Phase I/IICambridge, MA (617) 301-7000

CUDC-101 Curis Phase ICambridge, MA (617) 503-6500

CX-4945 Cylene Pharmaceuticals (see also multiple myeloma, other) Phase ISan Diego, CA (858) 875-5100

CYC-116 Cyclacel Pharmaceuticals Phase IBerkeley Heights, NJ (908) 517-7330

CYT-107 Cytheris (see also kidney, leukemia, skin) Phase IRockville, MD (301) 231-0450

CYT 6091 CytImmune Sciences Phase IRockville, MD (240) 864-2796

darinaparsin ZIOPHARM Oncology (see also leukemia, liver, Phase I(ZIO-101) New York, NY multiple myeloma) (646) 214-0700

Davanat™ Pro-Pharmaceuticals (see also colorectal) Phase Igalactomannan C Newton, MA (617) 559-0033

denibulin MediciNova Phase I(MN-029) San Diego, CA (858) 373-1500

DMPEN Antisoma Phase ICambridge, MA (617) 225-0522

E6201 Eisai advanced solid tumors Phase IWoodcliff Lake, NJ (888) 422-4743

E7050 Eisai Phase IWoodcliff Lake, NJ (888) 422-4743

E7080 Eisai (see also other) Phase I/IIWoodcliff Lake, NJ (888) 422-4743

ENMD-2076 EntreMed refractory metastatic disease Phase IRockville, MD (see also multiple myeloma) (240) 864-2600

eniluracil Adherex Technologies (see also liver) Phase IDurham, NC (919) 484-8484



eribulin mesylate Eisai advanced solid tumors, solid tumors Phase I(E7389) Woodcliff Lake, NJ (see also breast, head/neck, lung, (888) 422-4743

ovarian, prostate, sarcoma)

Exherin™ Adherex Technologies (see also skin) Phase II(ADH-1) Durham, NC (919) 484-8484

EZN-2968 Enzon Pharmaceuticals (see also lymphoma) Phase IBridgewater, NJ (866) 792-5172

FP-1039 Five Prime Therapeutics Phase ISan Francisco, CA (415) 365-5600

Genasense® Genta brief, high-dose IV-infusion Phase I/IIoblimersen Berkeley Heights, NJ (see also breast, leukemia, lung, (908) 286-9800

lymphoma, skin)--------------------------------------------------------------------------------------intermittent therapy Phase I

(908) 286-9800

GMX-1777 Gemin X Biotechnologies (see also lymphoma, skin) Phase IMontreal, Canada (514) 281-8989

HGS-1029 Human Genome Sciences Phase IRockville, MD (301) 309-8504

HMN-214 NS Pharma Phase IParsippany, NJ (973) 285-7010

IMC-3G3 Eli Lilly Phase IIndianapolis, IN (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-18F1 Eli Lilly Phase IIndianapolis, IN (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly solid tumors in adolescents and Phase I/IIIndianapolis, IN children (800) 545-5979ImClone Systems (see also breast, colorectal, (212) 645-1405New York, NY head/neck, liver, lung, pancreatic,

prostate, sarcoma)--------------------------------------------------------------------------------------solid tumor combination therapy, Phase Iother solid tumors (800) 545-5979

(212) 645-1405

IMGN-242 ImmunoGen (see also stomach) Phase ICambridge, MA (617) 995-2500

IMGN-388 ImmunoGen Phase ICambridge, MA (617) 679-5500

INNO-206 CytRx Phase ILos Angeles, CA (310) 826-5648

INNO-305 CytRx (see also leukemia) Phase ILos Angeles, CA (310) 826-5648



IPI-493 Infinity Pharmaceuticals Phase ICambridge, MA (617) 453-1000

IPI-926 Infinity Pharmaceuticals Phase ICambridge, MA (617) 453-100

JI-101 Jubilant Innovation Phase IBedminster, NJ (215) 369-0965

JNJ-38877605 Johnson & Johnson Phase IPharmaceutical Research (800) 817-5286& DevelopmentRaritan, NJ

JX-594 Jennerex Biotherapeutics (see also liver) Phase ISan Francisco, CA (415) 281-8886

LE-DT NeoPharm Phase ILake Bluff, IL (847) 887-0800

lexatumumab Human Genome Sciences Phase IRockville, MD (301) 309-8504

L-MDAM BioNumerik Phase IPharmaceuticals (210) 614-1701San Antonio, TX

LP-261 Locus Pharmaceuticals Phase IBlue Bell, PA (215) 358-2000


LY2181308 Eli Lilly (see also leukemia) Phase IIIndianapolis, IN (800) 545-5979Isis Pharmaceuticals (760) 931-9200Carlsbad, CA

LY2275796 Eli Lilly Phase IIndianapolis, IN (800) 545-5979Isis Pharmaceuticals (760) 931-9200Carlsbad, CA



M1685A Genentech Phase ISouth San Francisco, CA (650) 224-1000

MDX-010 Bristol-Myers Squibb (see also skin) in clinical trials(ipilimumab) Princeton, NJ (212) 546-4000

MedarexPrinceton, NJ

MDX-1105 Medarex Phase IPrinceton, NJ (609) 430-2880





MEDI-575 MedImmune Phase IGaithersburg, MD (301) 398-0000

MetmAb Genentech Phase ISouth San Francisco, CA (650) 225-1000

MGCD-265 MethylGene Phase IMontreal, Canada (514) 337-3333

MGCD-0103 MethylGene combination therapy Phase I/IIMontreal, Canada (see also leukemia, lymphoma) (514) 337-3333

--------------------------------------------------------------------------------------monotherapy Phase I

(514) 337-3333

MK-0731 Merck Phase I completedWhitehouse Station, NJ (800) 672-6372



MK-5108 Merck refractory metastatic disease Phase IWhitehouse Station, NJ (800) 672-6372Vertex PharmaceuticalsCambridge, MA

MKC1106-PP MannKind Phase IValencia, CA (661) 775-5300

MLN4924 Millennium (see also leukemia) Phase IPharmaceuticals (800) 390-5663Cambridge, MA

MLN8237 Millennium (see also brain, leukemia, Phase IPharmaceuticals lymphoma) (800) 390-5663Cambridge, MA

MM-121 Merrimack Pharmaceuticals Phase ICambridge, MA (617) 441-1000

MN-201 Marillion advanced solid tumors Phase IPharmaceuticals (610) 644-5732Malvern, PA

MORAb-004 Eisai Phase IWoodcliff Lake, NJ (888) 422-4743

MP-470 SuperGen Phase IDublin, CA (925) 560-0100

MSX-122 Metastatix late-stage solid tumors Phase ITucker, GA (678) 367-0720

NB-1011 Kiadis Pharma Phase I/IIAmsterdam, The Netherlands



NKTR-105 Nektar Therapeutics Phase ISan Carlos, CA (650) 631-3100

NPI-0052 Nereus Pharmaceuticals (see also lymphoma, Phase ISan Diego, CA multiple myeloma) (858) 587-4090

oleandrin Ozelle Pharmaceuticals Phase I(nerium oleander San Antonio, TX (309) 949-3745extract)

OMP-21M18 GlaxoSmithKline Phase IRsch. Triangle Park, NC (888) 825-5249OncoMed Pharmaceuticals (650) 995-8200Redwood City, CA

omtriptolide Pharmagenesis Phase IPalo Alto, CA (650) 813-1818Pierre Fabre (973) 898-1042PharmaceuticalsParsippany, NJ

ON-01910 Onconova Therapeutics (see also leukemia) Phase IPrinceton, NJ (609) 844-7735

Oncaspar® Enzon Pharmaceuticals combination therapy Phase Ipegaspargase Bridgewater, NJ (see also lymphoma) (866) 792-5172

OSI-906 OSI Pharmaceuticals Phase IMelville, NY (631) 962-2000

OSI-930 OSI Pharmaceuticals Phase IMelville, NY (631) 962-2000

PI3 kinase Genentech Phase Iinhibitor South San Francisco, CA (650) 224-1000

palifosfamide ZIOPHARM Oncology combination therapy Phase I(ZIO-201) New York, NY (see also sarcoma) (212) 214-0700

PCI-24781 Pharmacyclics (see also leukemia) Phase ISunnyvale, CA (408) 774-0330

PDL-192 Facet Biotech Phase IRedwood City, CA (650) 454-1000

PF-477736 Pfizer Phase INew York, NY (860) 732-5156


PF-4856882 Pfizer Phase I(CovX045) New York, NY (860) 732-5156

PG-11047 Progen Pharmaceuticals Phase IRedwood City, CA (650) 610-7800

PM-00104 PharmaMar USA (see also lymphoma) Phase ICambridge, MA (617) 868-3797

PM-02734 PharmaMar USA Phase ICambridge, MA (617) 868-3797

PRLX-93936 Prolexys Pharmaceuticals Phase ISalt Lake City, UT (801) 303-1700



PRX-321 Protox Therapeutics (see also brain) Phase I completedVancouver, Canada (604) 688-0199

PX-478 Oncothyreon (see also lymphoma) Phase ISeattle, WA (206) 801-2100

PX-866 Oncothyreon Phase ISeattle, WA (206) 801-2100

R547 Roche Phase INutley, NJ (973) 235-5000

R763 EMD Serono Phase IRockland, MA (800) 283-8088Rigel Pharmaceuticals (650) 624-1100South San Francisco, CA



R7112 Roche (see also leukemia) Phase INutley, NJ (973) 235-5000




RH-1 Allos Therapeutics (see also lymphoma) Phase IWestminster, CO (303) 426-6262

rinfabate Insmed Phase I completed(rhIGFBP-3) Glen Allen, VA (804) 565-3000

RO-4987655 Roche Phase INutley, NJ (973) 235-5000

RO-5083945 Roche Phase INutley, NJ (973) 235-5000

sardomozide Novartis Pharmaceuticals (see also lymphoma) Phase IEast Hanover, NJ (888) 669-6682

SCH-900776 Schering-Plough (see also lymphoma) Phase IKenilworth, NJ (908) 298-4000

SF1126 Semafore Pharmaceuticals (see also mutliple myeloma) Phase IIndianapolis, IN (317) 876-3075

simotaxel Taxolog Phase IFairfield, NJ (877) 829-6564Wyeth Pharmaceuticals (800) 934-5556Collegeville, PA

SN2310 OncoGenex Phase IPharmaceuticals (425) 686-1500Bothell, WA



SNS-032 Sunesis Pharmaceuticals (see also lymphoma) Phase I/IISouth San Francisco, CA (650) 266-3500

SNS-314 Sunesis Pharmaceuticals Phase ISouth San Francisco, CA (650) 266-3500

sonepcizumab Lpath Phase ISan Diego, CA (858) 678-0800

SPI-1620 Spectrum Pharmaceuticals adjunctive treatment Phase IIrvine, CA (949) 788-6700

Sprycel™ Bristol-Myers Squibb (see also leukemia, prostate) in clinical trialsdasatinib Princeton, NJ (212) 546-4000

SSR97225 sanofi-aventis Phase IBridgewater, NJ (800) 633-1610

STA-9090 Synta Pharmaceuticals (see also leukemia) Phase ILexington, MA (781) 274-8200

TAK593 Millennium Phase IPharmaceuticals (800) 390-5663Cambridge, MA

tanespimycin Bristol-Myers Squibb (see also multiple myeloma) Phase II(Hsp90 inhibitor) Princeton, NJ (212) 546-4000

Tarvacin™ Peregrine Pharmaceuticals Phase Ibavituximab Tustin, CA (714) 508-6000

TGF beta inhibitor Eli Lilly Phase IIndianapolis, IN (800) 545-5979

TH-302 Threshold combination therapy Phase I/IIPharmaceuticals (see also sarcoma) (650) 474-8200Redwood City, CA --------------------------------------------------------------------------------------

monotherapy Phase I(650) 474-8200

TLC388 Taiwan Liposome Phase ITaipei, Taiwan

TRC-093 TRACON Pharmaceuticals Phase ISan Diego, CA (858) 550-0780

tricirbine VioQuest Pharmaceuticals (see also leukemia) Phase I/II(VQD-002) Basking Ridge, NJ (908) 766-4400

TST-10088 Twinstrand Therapeutics Phase INorth Vancouver, Canada (604) 960-0857

UNBS-5162 Drais Pharmaceuticals (see also lymphoma) Phase IBridgewater, NJ (908) 895-1200

V935 Merck Phase IIIWhitehouse Station, NJ (800) 672-6372

Velcade® Millennium (see also lung, lymphoma, Phase I/IIbortezomib Pharmaceuticals multiple myeloma) (800) 390-5663

Cambridge, MA

vinorelbine Hana Biosciences (see also lymphoma) Phase Iliposomal South San Francisco, CA (650) 588-6404



VQD-001 VioQuest Pharmaceuticals Phase I/IIBasking Ridge, NJ (908) 766-4400

WX UK1 Wilex combination therapy Phase IMunich, Germany www.wilex.com

XL-147 Exelixis Phase ISouth San Francisco, CA (650) 837-7000

XL-281 Bristol-Myers Squibb Phase I(RAF kinase Princeton, NJ (212) 546-4000inhibitor) Exelixis

South San Francisco, CA

XL-518 Exelixis Phase I(MEK inhibitor) South San Francisco, CA (650) 837-7000

GenentechSouth San Francisco, CA

XL-765 Exelixis (see also brain) Phase ISouth San Francisco, CA (650) 837-7000

XL-888 Exelixis Phase ISouth San Francisco, CA (650) 837-7000

XMT-1001 Mersana Therapeutics refractory metastatic disease Phase ICambridge, MA (617) 498-0020

ZEN-012 AEterna Zentaris (see also lymphoma) Phase IWarren, NJ (908) 626-5428

ZIO-301 ZIOPHARM Oncology combination therapy Phase I/II(indibulin) New York, NY (646) 214-0700

--------------------------------------------------------------------------------------monotherapy Phase I

(646) 214-0700

S T O M A C H C A N C E RProduct Name Sponsor Indication Development Status

Advexin® Introgen Therapeutics esophageal cancer Phase I/IIcontusugene Austin, TX (see also bladder, brain, breast, (512) 708-9310ladenovec head/neck, lung, ovarian, prostate)

AMG 102 Amgen gastric cancer Phase I/IIThousand Oaks, CA (see also brain, colorectal, (805) 447-1000

kidney, lung)

AMG 386 Amgen gastrointestinal cancer Phase IIThousand Oaks, CA (see also breast, kidney, ovarian, (805) 447-1000

other)

AV-951 AVEO Pharmaceuticals gastrointestinal cancer Phase I/IICambridge, MA (combination therapy) (617) 299-5000

(see also kidney, lung)



Avastin® Genentech gastric cancer (combination Phase IIIbevacizumab South San Francisco, CA therapy), gastrointestinal (650) 225-1000

stromal tumor (GIST) (see also brain, colorectal, head/neck, kidney, liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, other)

CNF-2024 Biogen Idec GIST Phase IICambridge, MA (see also breast, leukemia, (617) 679-2000

solid tumors)

Erbitux® Bristol-Myers Squibb esophageal cancer, gastric cancer Phase IIIcetuximab Princeton, NJ (see also bladder, colorectal, (212) 546-4000

Eli Lilly head/neck, lung, prostate) (800) 545-5979Indianapolis, IN (212) 645-1405ImClone SystemsNew York, NY

Herceptin® Genentech esophageal cancer, gastric cancer Phase IIItrastuzumab South San Francisco, CA (see also colorectal, ovarian, (650) 225-1000

pancreatic, prostate, other)

Hycamtin® GlaxoSmithKline esophageal cancer, gastric cancer Phase IItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, other)

IMGN-242 ImmunoGen gastric cancer Phase IICambridge, MA (see also solid tumors) (617) 995-2500

Levulan® PD DUSA Pharmaceuticals gastrointestinal cancer in clinical trialsaminolevulinic acid Wilmington, MA (see also bladder, cervical, (978) 657-7500

colorectal, lung)

masitinib AB Science USA GIST Phase IIIShort Hills, NJ (see also leukemia, pancreatic) (973) 218-2437

OncoGel™ Protherics esophageal cancer Phase IIBrentwood, TN (see also brain, pancreatic) (615) 327-1027

Oncophage® Antigenics (see also brain, colorectal, kidney, Phase I/IIvitespen New York, NY pancreatic, skin) (866) 805-8994

Opaxio™ Cell Therapeutics esophageal cancer, gastric cancer Phase Ipaclitaxel Seattle, WA (see also lung, ovarian, other) (800) 215-2355poliglumex Novartis Pharmaceuticals (888) 669-6682

East Hanover, NJ

PN401 Wellstat Therapeutics (see also colorectal, pancreatic) Phase IIGaithersburg, MD (240) 631-2500

PX-12 Oncothyreon gastrointestinal cancer Phase ISeattle, WA (see also pancreatic, other) (206) 801-2100

retaspimycin Infinity Pharmaceuticals GIST Phase III(IPI 504) Cambridge, MA (see also breast, lung) (617) 453-1000(Orphan Drug)



Sutent® Pfizer gastric cancer (combination therapy) Phase IIsunitinib New York, NY (see also breast, colorectal, liver, (860) 732-5156

lung, pancreatic, prostate, sarcoma)

TAS-102 Taiho Pharma USA gastric cancer Phase IIPrinceton, NJ (609) 750-5300

Tasigna® Novartis Pharmaceuticals GIST Phase IIInilotinib East Hanover, NJ (see also leukemia) (888) 669-6682(Orphan Drug)tesetaxel Genta second-line therapy Phase II(Orphan Drug) Berkeley Heights, NJ (see also colorectal) (908) 286-9800

TheraCIM™ YM Biosciences esophageal cancer Phase IInimotuzumab Wayne, PA (neoadjuvant therapy) (610) 560-0600

(see also brain, breast, prostate)

TNFerade™ GenVec esophageal cancer Phase II completedGaithersburg, MD (see also colorectal, head/neck, (240) 632-0740

pancreatic, skin)

Tykerb® GlaxoSmithKline gastric cancer (combination therapy) Phase IIIlapatinib Rsch. Triangle Park, NC (see also brain, head/neck) (888) 825-5249

Xeloda® Roche esophageal cancer Phase IIcapecitabine Nutley, NJ (see also colorectal) (973) 235-5000

XL-880 Exelixis gastric cancer Phase IISouth San Francisco, CA (see also head/neck, kidney) (650) 837-7000GlaxoSmithKline (888) 825-5249Rsch. Triangle Park, NC

C A N C E R / C H E M O T H E R A P Y - R E L A T E D C O N D I T I O N SProduct Name Sponsor Indication Development Status

802-2 Adeona Pharmaceuticals graft-versus-host disease Phase I/IIAnn Arbor, MI (734) 332-7800

Acapodene® GTx complications from androgen application submittedtoremifene Memphis, TN deprivation therapy (901) 523-9700

(see also prostate)

acetylcysteine Adherex Technologies chemoprotection Phase I/IIDurham, NC (919) 484-8484

AKR-501 Eisai idiopathic thrombocytopenic Phase IIWoodcliff Lake, NJ purpura (888) 422-4743

Aredia® Novartis Pharmaceuticals cancer pain Phase IIIpamidronic acid East Hanover, NJ (see also multiple myeloma) (888) 669-6682

Bexxar® GlaxoSmithKline myeloablation Phase IItositumomab Rsch. Triangle Park, NC (see also leukemia, lymphoma) (888) 825-5249

CB-1400 Canopus BioPharma mucositis (prevention) Phase IIStudio City, CA (818) 980-5008

CJ-15161 Pfizer cancer pain Phase IINew York, NY (860) 732-5156



denosumab Amgen bone loss induced by hormone- Phase III(AMG 162) Thousand Oaks, CA ablation therapy in breast or (805) 447-1000

prostate cancers, prevention of cancer-related bone damage in breast, prostate, or solid tumors(see also multiple myeloma, other)

Elitek® sanofi-aventis chemotherapy-induced application submittedrasburicase Bridgewater, NJ hyperuricemia in adults (800) 633-1610

Enbrel® Amgen graft-versus-host disease Phase IIetanercept Thousand Oaks, CA (805) 447-1000

Wyeth Pharmaceuticals (800) 934-5556Collegeville, PA

fentanyl sublingual INSYS Therapeutics cancer pain Phase IIIspray Phoenix, AZ (602) 910-2617

fentanyl sublingual Sosei R&D cancer pain Phase I(SRSS-001) Tokyo, Japan

fentanyl transdermal Lavipharm cancer pain Phase IIIpatch East Windsor, NJ (609) 448-3001

Fosamax® Merck bone loss associated with androgen Phase IIalendronic acid Whitehouse Station, NJ deprivation therapy in prostate (800) 672-6372

cancer

golotimod SciClone Pharmaceuticals mucositis (prevention) Phase IIFoster City, CA (650) 358-3456

In-111-DAC Naviscan cancer diagnostic imaging Phase ISan Diego, CA (858) 587-3641

LGD-4665 GlaxoSmithKline treatment-induced Phase IIRsch. Triangle Park, NC thrombocytopenia (888) 825-5249

morphine intranasal MDRNA cancer pain Phase IIBothell, WA (425) 908-3600

MRX-1024 Molecular Therapeutics mucositis Phase IAnn Arbor, MI (734) 259-4574

Nasalfent® Archimedes Pharma cancer pain Phase IIIfentanyl intranasal Reading, United Kingdom

Neumega® Wyeth Pharmaceuticals chemotherapy-induced mucositis Phase IIoprelvekin Collegeville, PA (800) 934-5556

--------------------------------------------------------------------------------------graft-versus-host disease Phase I/II

(800) 934-5556

Neuprex® XOMA graft-versus-host disease Phase I/IIopebacan Berkeley, CA in patients undergoing (510) 204-7200

allogeneic hematopoetic stem cell transplantation

Nipent® Hospira graft-versus-host disease Phase II/IIIpentostatin Lake Forest, IL (see also leukemia, lymphoma) (224) 212-2000

NP-2 Diamyd Medical cancer pain Phase Igene therapy Pittsburgh, PA (412) 770-1310



Nplate™ Amgen chemotherapy-induced Phase IIromiplostim Thousand Oaks, CA thrombocytopenia (805) 447-1000

(see also leukemia)

ondansetron MonoSol Rx chemotherapy- and radiotherapy- Phase IIIoral film Warren, NJ induced nausea and vomiting (219) 672-8112

Strativa Pharmaceuticals (201) 802-4206Woodcliff Lake, NJ

ondansetron NovaDel Pharma chemotherapy- and radiotherapy- Phase IIIoral spray Flemington, NJ induced nausea and vomiting (908) 782-3431

Strativa Pharmaceuticals (201) 802-4206Woodcliff Lake, NJ

Onsolis™ BioDelivery Sciences cancer pain application submittedfentanyl Morrisville, NC (919) 653-5160transmucosal Meda Pharmaceuticals

Somerset, NJ

orBec® DOR BioPharma graft-versus-host disease application submittedbeclometasone Ewing, NJ (609) 538-8200(Orphan Drug) Sigma-Tau Pharmaceuticals (800) 447-0169

Gaithersburg, MD --------------------------------------------------------------------------------------graft-versus-host disease (prevention) Phase II

(609) 538-8200(800) 447-0169

PF-4383119 Pfizer cancer pain Phase II(tanezumab) New York, NY (860) 732-5156

PHY-906 PhytoCeutica chemoprotection Phase I/IINew Haven, CT (203) 777-3462

Phytosel® iBioPharma chemoprotection Phase INewark, DE (302) 355-0650

PMI-150 Javelin Pharmaceuticals cancer pain Phase III(ketamine Cambridge, MA (617) 349-4500intranasal)

Prochymal® Osiris Therapeutics graft-versus-host disease Phase IIIhuman Columbia, MD (443) 545-1800mesenchymal stem cell therapy(Orphan Drug)Prograf® Astellas Pharma US graft-versus-host disease application submittedtacrolimus Deerfield, IL (800) 727-7003

Rapamune® Wyeth Pharmaceuticals bone marrow transplant rejection Phase IIsirolimus Collegeville, PA (see also unspecified) (800) 934-5556

Rapinyl™ Orexo breakthrough cancer pain Phase IIIfentanyl sublingual Uppsala, Sweden(EN 3267) ProStrakan

Galashiels, United Kingdom



Reviroc™ Kiadais Pharma bone marrow transplant rejection Phase II(Orphan Drug) St. Laurent, Canada (514) 336-4886

--------------------------------------------------------------------------------------graft-versus-host disease Phase I/II

(514) 336-4886

Sativex® Otsuka America cancer pain Phase II/IIIdronabinol/ Pharmaceutical (800) 562-3974cannabidiol Rockville, MD

SCH-58500 Schering-Plough myeloablation Phase I(p53 gene therapy) Kenilworth, NJ (see also bladder, head/neck, (908) 298-4000

liver, lung)

STS Adherex Technologies chemoprotection Phase IIIDurham, NC (919) 484-8484

Tavocept™ BioNumerik chemoprotection Phase IIIdimesna Pharmaceuticals (210) 614-1701

San Antonio, TX

Telintra® Telik chemotherapy-induced neutropenia Phase IIezatiostat Palo Alto, CA (see also leukemia) (650) 845-7700

Titragesia™ ZARS Pharma cancer pain Phase IIIfentanyl patch Salt Lake City, UT (801) 350-0202

totrombopag GlaxoSmithKline thrombocytopenia Phase IRsch. Triangle Park, NC (888) 825-5249

Urso Forte™ Axcan Pharma chemoprevention Phase IIursodeoxycholic Birmingham, AL (see also colorectal) (205) 991-8085acid

veltuzumab Immunomedics chemotherapy-induced immune Phase I/II(IMMU-106) Morris Plains, NJ thrombocytopenic purpura (973) 605-8200

(see also lymphoma)

Voraxaze™ Protherics chemoprotection application submittedglucarpidase Brentwood, TN (615) 327-1027

xaliproden sanofi-aventis chemotherapy-induced Phase IIIBridgewater, NJ neuropathies (800) 633-1610

ZRx101 ZelleRx graft-versus-host disease Phase IChicago, IL (see also kidney, (312) 243-5200

multiple myeloma, skin)

O T H E R C A N C E R SProduct Name Sponsor Indication Development Status

3F8 mAb United Therapeutics central nervous system cancer Phase IISilver Spring, MD (see also brain) (301) 608-9292

°A6 Angstrom Pharmaceuticals advanced gynecological cancer Phase ISolana Beach, CA (see also ovarian) (858) 314-2356



aflibercept sanofi-aventis symptomatic malignant ascites Phase III(VEGF-trap) Bridgewater, NJ (see also colorectal, lung, (800) 633-1610

Regeneron Pharmaceuticals pancreatic, prostate) (914) 345-7400Tarrytown, NY

AMG 386 Amgen fallopian tube cancer, Phase IIThousand Oaks, CA peritoneal cancer (805) 447-1000

(see also breast, kidney, ovarian, stomach)

Armala™ GlaxoSmithKline fallopian tube cancer, Phase IIpazopanib Rsch. Triangle Park, NC peritoneal cancer (888) 825-5249

(see also brain, breast, cervical,kidney, liver, lung, ovarian, sarcoma)

ARQ-501 ArQule leiomyoma Phase II(beta lapachone) Woburn, MA (see also head/neck, pancreatic, (781) 994-0300

solid tumors)

ATI-BC-1 Algeta bone cancer (metastatic from Phase IOslo, Norway hormone-refractory prostate cancer) www.algeta.com

atiprimod Callisto Pharmaceuticals carcinoid tumor Phase IINew York, NY (212) 297-0010

Avastin® Genentech fallopian tube cancer, Phase IIIbevacizumab South San Francisco, CA peritoneal cancer (650) 225-1000

(see also brain, colorectal, head/neck, kidney, liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach)

axitinib Pfizer thyroid cancer Phase IINew York, NY (see also colorectal, kidney, lung, (860) 732-5156

solid tumors)

AZD6244 AstraZeneca thyroid cancer Phase IIWilmington, DE (see also leukemia, liver, lung, (800) 236-9933

multiple myeloma, ovarian, pancreatic, skin)

Azedra™ Molecular Insight neuroendocrine tumors Phase I/IIiodine-labeled Pharmaceuticals (see also brain) (617) 492-5554metaiodobenzyl- Cambridge, MAguanidine(Orphan Drug)Bonefos® Bayer HealthCare cancer metastases application submittedclodronic acid Pharmaceuticals (888) 842-2937

Wayne, NJ

BSI-201 BiPar Sciences fallopian tube cancer, peritoneal Phase IIBrisbane, CA cancer, uterine cancer (650) 635-6050

(see also brain, breast, ovarian)

catumaxomab Fresenius Biotech malignant ascites Phase IINorth America (see also ovarian) www.fresenius-biotech.comWaltham, MA



CDB-4124 Repros Therapeutics uterine leiomyoma Phase IIIThe Woodlands, TX (281) 719-3400

CS-7017 Daiichi Sankyo thyroid cancer Phase IParsippany, NJ (see also lung) (973) 359-2600

CX-4945 Cylene Pharmaceuticals giant lymph node hyperplasia Phase ISan Diego, CA (see also multiple myeloma, (858) 875-5100

solid tumors)

D4064A Genentech fallopian tube cancer, Phase ISouth San Francisco, CA peritoneal cancer (650) 224-1000

(see also ovarian)

deforolimus ARIAD Pharmaceuticals endometrial cancer Phase II(MK-8669) Cambridge, MA (see also breast, lung, prostate, (617) 494-0400

Merck sarcoma) (800) 672-6372Whitehouse Station, NJ

denosumab Amgen prevention of bone metastases Phase III(AMG 162) Thousand Oaks, CA (see also multiple myeloma, (805) 447-1000

cancer-related)

DM-CHOC-PEN Dekk-Tec central nervous system cancer Phase INew Orleans, LA (504) 583-6135

E7080 Eisai thyroid cancer Phase IIWoodcliff Lake, NJ (see also solid tumors) (888) 422-4743

EC-20 Endocyte diagnosis of folate receptor- Phase IIWest Lafayette, IN positive cancers (765) 463-7175

EC-145 Endocyte endometrial cancer Phase IIWest Lafayette, IN (see also lung, ovarian) (765) 463-7175

everolimus Novartis Pharmaceuticals neuroendocrine tumors Phase IIIEast Hanover, NJ (see also kidney, pancreatic) (888) 669-6682

Herceptin® Genentech salivary gland cancer Phase IItrastuzumab South San Francisco, CA (see also colorectal, ovarian, (650) 225-1000

pancreatic, prostate, stomach)

Hycamtin® GlaxoSmithKline uterine cancer Phase IItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach)

idronoxil Marshall Edwards fallopian tube cancer Phase I/IINorth Ryde, Australia (combination therapy)

(see also ovarian, prostate)

ING 1 Aduro BioTech adenocarcinoma Phase IBerkeley, CA (510) 848-4400

MCS110 Novartis Pharmaceuticals bone cancer Phase I/IIEast Hanover, NJ (see also prostate) (888) 669-6682

MER-101 Merrion Pharmaceuticals bone cancer Phase IIWilmington, NC (910) 799-1847



MK-0646 Merck neuroendocrine tumors Phase IIWhitehouse Station, NJ (see also breast, lung, pancreatic) (888) 669-6682

MK-0822 Merck bone cancer Phase III completedWhitehouse Station, NJ (800) 672-6372

motesanib Amgen thyroid cancer Phase IIThousand Oaks, CA (see also breast, colorectal, lung) (805) 447-1000Millennium (800) 390-5663PharmaceuticalsCambridge, MA

NBI-42902 Neurocrine Biosciences uterine leiomyoma Phase ISan Diego, CA (see also breast, prostate) (858) 617-7600

Norprolac® Ferring Pharmaceuticals prolactinoma Phase IIquinagolide Suffern, NY www.ferring.com

Opaxio™ Cell Therapeutics peritoneal cancer Phase IIpaclitaxel Seattle, WA (see also lung, ovarian, stomach) (800) 215-2355poliglumex Novartis Pharmaceuticals (888) 669-6682

East Hanover, NJ --------------------------------------------------------------------------------------fallopian tube cancer Phase I/II

(800) 215-2355(888) 669-6682

pasireotide Novartis Pharmaceuticals neuroendocrine tumors Phase I completedEast Hanover, NJ (888) 669-6682

PX-12 Oncothyreon metastatic disease Phase ISeattle, WA (see also pancreatic, stomach) (206) 801-2100

Quadramet® Cytogen cancer metastases Phase IIIsamarium sm-153 Princeton, NJ (see also multiple myeloma, (800) 833-3533lexidronam prostate, sarcoma)injection

quarfloxin Cylene Pharmaceuticals neuroendocrine tumors Phase IISan Diego, CA (858) 875-5100

RAV-12 Raven Biotechnologies adenocarcinoma Phase I/IISouth San Francisco, CA (see also pancreatic) (650) 624-2600

relacatib GlaxoSmithKline cancer metastases Phase II(cathepsin Rsch. Triangle Park, NC (888) 825-5249K inhibitor)

Revlimid® Celgene central nervous system cancer Phase IIlenalidomide Summit, NJ (see also leukemia, lymphoma, (908) 673-9000


saracatinib AstraZeneca metastatic bone cancer Phase IIWilmington, DE (800) 236-9933

seliciclib Cyclacel Pharmaceuticals nasopharyngeal cancer Phase IIShort Hills, NJ (see also lung) (973) 847-5955

Somatuline Tercica neuroendocrine tumors Phase IIIAutogel® Brisbane, CA (650) 624-4900lanreotide



Tarceva® Genentech gynecological cancer Phase IIerlotinib South San Francisco, CA (combination therapy) (650) 224-1000

OSI Pharmaceuticals (see also bladder, brain, breast, (800) 572-1932Melville, NY colorectal, head/neck, liver, lung)

Taxotere® sanofi-aventis pediatric cancer Phase IIIdocetaxel Bridgewater, NJ (800) 633-1610

V503 Merck vulvovaginal cancer prevention Phase IIIWhitehouse Station, NJ (see also cervical) (800) 672-6372

XL-184 Bristol-Myers Squibb medullary thyroid cancer Phase IIIPrinceton, NJ (see also brain) (212) 546-4000ExelixisSouth San Francisco, CA

Yondelis® Johnson & Johnson endometrial cancer Phase IItrabectedin Pharmaceutical Research (see also breast, ovarian, (800) 817-5286

& Development prostate, sarcoma)Raritan, NJ

Zactima® AstraZeneca medullary thyroid cancer Phase IIIvandetanib Wilmington, DE (see also brain, breast, lung) (800) 236-9933

Zybrestat™ OXiGENE thyroid cancer (combination therapy) Phase II/IIIfosbretabulin Waltham, MA (see also head/neck, lung, ovarian) (781) 547-5900(Orphan Drug)

U N S P E C I F I E D C A N C E R S( D R U G S T H A T H A V E P O T E N T I A L F O R O N E O R M O R E O F T H E P R E V I O U S C A N C E R S )Product Name Sponsor Indication Development Status

1059615 GlaxoSmithKline Phase IRsch. Triangle Park, NC (888) 825-5249

1120212 GlaxoSmithKline Phase IRsch. Triangle Park, NC (888) 825-5249

AFX-9901 Afecta Pharmaceuticals in clinical trialsIrvine, CA (949) 253-4688

AG-24322 Pfizer Phase INew York, NY (860) 732-5156

AGS-16M18 Agensys Phase ISanta Monica, CA (310) 820-8029Astellas Pharma US (800) 477-6472Deerfield, IL

ALT-801 Altor BioScience Phase I/IIMiramar, FL (954) 443-8600

anti-HGF mAb Schering-Plough Phase IKenilworth, NJ (908) 298-4000

ANX-514 ADVENTRX Pharmaceuticals Phase I(docetaxel San Diego, CA (858) 552-0866emulsion)



ARRY-300 Array BioPharma Phase IBoulder, CO (303) 381-6600



AVR-118 Advanced Viral Research Phase IIYonkers, NY (914) 376-7383

belotecan ALZA Phase IMountain View, CA (650) 564-5000

BIO-109 Evolve Oncology Phase IINew York, NY (646) 723-8941

BIO-113 Evolve Oncology Phase IINew York, NY (646) 723-8941

BIO-121 Evolve Oncology Phase INew York, NY (646) 723-8941

BIO-128 Evolve Oncology Phase INew York, NY (646) 723-8941

BLX-883 Biolex Phase IPittsboro, NC (919) 542-9901

carbendazim Arisyn Therapeutics Phase IFrederick, MD (301) 644-3921

CLT-001 Cellerant Therapeutics Phase IISan Carlos, CA (650) 232-2122

CNDO-101 Coronado Biosciences Phase ISan Diego, CA (510) 396-5709

CPI-613 Cornerstone Phase IPharmaceuticals (609) 409-7050Cranbury, NJ

EC-0225 Endocyte Phase IWest Lafayette, IN (765) 463-7175

ENMD-1198 EntreMed Phase IRockville, MD (240) 864-2600

EZN-2208 Enzon Pharmaceuticals Phase IBridgewater, NJ (866) 792-5172

F50035 Merck Phase IIWhitehouse Station, NJ (800) 672-6372Pierre Fabre MedicamentCastres, France

Fibrovax™ Cytokine PharmaSciences Phase Icancer vaccine King of Prussia, PA (610) 687-1776

GPX-150 Gem Pharmaceuticals Phase I/IIBirmingham, AL (205) 982-0320



HuCAL fully Centocor Phase Ihuman antibody Horsham, PA (610) 651-6000

MorphoSysMartinsried, Germany

IAP antagonist Genentech Phase ISouth San Francisco, CA (650) 224-1000

IMC-18F1 ImClone Systems Phase INew York, NY (212) 645-1405

Imprime PGG™ Biothera Phase IEagen, MN (651) 675-0300

JNJ-26483327 Johnson & Johnson in clinical trialsPharmaceutical Research (800) 817-5286& DevelopmentRaritan, NJ

KX2-391 Kinex Pharmaceuticals Phase IBuffalo, NY (716) 881-8984

LBY135 Novartis Pharmaceuticals Phase IEast Hanover, NJ (888) 669-6682

LOR-2501 Lorus Therapeutics Phase IToronto, Canada (416) 798-1200

LR-103 Genzyme Phase ICambridge, MA (617) 252-7500



MK-2461 Merck Phase I/IIWhitehouse Station, NJ (800) 672-6372



MKI833 Wyeth Pharmaceuticals Phase 0Collegeville, PA (800) 934-5556

NRX-4204 NuRx Pharmaceuticals Phase IIrvine, CA (949) 336-7111

OSI-7904L OncoVista Phase IISan Antonio, TX (210) 677-6000

oxaliplatin Mebiopharm Phase Iliposomal Tokyo, Japan www.mebiopharm.com

PBI-05204 Phoenix Biotechnology Phase ISan Antonio, TX (877) 593-8945

PCI-27483 Pharmacyclics Phase ISunnyvale, CA (408) 774-0330











PF-4856884 Pfizer Phase I(CovX060) New York, NY (860) 732-5156


PHA-848125 Nerviano Medical Sciences Phase INerviano, Italy www.nervianoms.com

plasmid DNA Merck Phase Icancer vaccine Whitehouse Station, NJ (800) 672-6372

Vical (858) 646-1100San Diego, CA

QBI-139 Quintessence Biosciences Phase IMadison, WI (608) 441-2950

R306465 Johnson & Johnson Phase IPharmaceutical (800) 817-5286Research & DevelopmentRaritan, NJ

Rapamune® Wyeth Pharmaceuticals (see also cancer-related) Phase Isirolimus Collegeville, PA (800) 934-5556

RDEA-119 Ardea Biosciences Phase I/IISan Diego, CA (858) 652-6500

RDEA-436 Ardea Biosciences Phase 0San Diego, CA (858) 652-6500

SJG-136 Ipsen Phase IMilford, MA (508) 478-8900

SNX-5422 Serenex Phase IDurham, NC (919) 281-6001

SRT-501 Sirtris Pharmaceuticals Phase IICambridge, MA (617) 252-6920



TAK-285 Millennium Phase IPharmaceuticals (800) 390-5663Cambridge, MA

taltobulin Wyeth Pharmaceuticals Phase ICollegeville, PA (800) 934-5556



V930 Merck Phase I(cancer vaccine) Whitehouse Station, NJ (800) 672-6372

Vical (858) 646-1100San Diego, CA

VTX-2337 VentiRx Pharmaceuticals Phase ISan Diego, CA (858) 436-1530

The content of this report has been obtained through industry sources and the Adis “R&D Insight” databasebased on the latest information. Report current as of March 23, 2009. The information may not be comprehensive.For more specific information about a particular product, contact the individual company directly or go towww.clinicaltrials.gov. The entire series of Medicines in Development is available on PhRMA’s web site.

A publication of PhRMA’s Communications & Public Affairs Department. (202) 835-3460

www.phrma.org | www.innovation.org | www.pparx.org | www.buysafedrugs.info | www.sharingmiracles.com

Provided as a Public Service by PhRMA. Founded in 1958 as the Pharmaceutical Manufacturers Association.

Copyright © 2009 by the Pharmaceutical Research and Manufacturers of America. Permission to reprint is awarded ifproper credit is given.


actinic keratoses—Roughness andthickening of the skin caused by over-exposure to the sun’s ultraviolet rays.It can degenerate into a skin cancercalled squamous cell carcinoma.

adenocarcinoma—Malignant tumorderived from a gland or glandulartissue.

adjunctive treatment—An auxiliarytreatment that is secondary to themain treatment.

adjuvant—A substance or drug thataids another substance in its action.

allogeneic—Refers to having celltypes that are distinct and causereactions in the immune system.

application submitted—An applica-tion for marketing has been submittedby the company to the Food andDrug Admin istra tion (FDA).

ascites—Excess fluid in the spacebetween the tissues lining theabdomen and abdominal organs (theperitoneal cavity).

basal cell cancer—Cancer of thelower layers of the skin.

B-cell—A class of white blood cellsimportant to the body’s immunesystem.

biliary—Relating to bile.

carcinoma—A malignant tumor thatarises from epithelial tissues, suchas skin.

cervical—Relating to the neck ofthe uterus.

chemoprotection—A therapeutictechnique in which bone marrowcells are removed from an individualwith cancer and are genetically mod-ified to withstand higher doses ofchemotherapy before being returnedto the donor.

cholangiocarcinoma—A malignancyof the biliary duct system that mayoriginate in the liver and extrahepaticbile ducts. More than 90 percent areadenocarcinomas, and the remainderare squamous cell tumors. Cholangio -carcinomas tend to grow slowly andto infiltrate the walls of the ducts. Eachyear, approximately 2,500 cases

occur, and the average incidence is1 case per 100,000 people per year.

cutaneous—Pertaining to the skin.

dysplasia—Abnormal tissue develop-ment.

gastric—Of or relating to the stomach.

GISTs—Gastrointestinal stromaltumors are uncommon tumors of theGI tract. Not all GISTs are cancerous;some are benign. Although thesecancers can arise anywhere in theGI tract, they occur most often inthe stomach (60% to 70%) and lesscommonly in the small intestine(20% to 30%). The rest are found inthe esophagus, large intestine, rectum,and anus. About 80% of people diag-nosed with GIST are older than 50.It is slightly more common in men.Blacks are more likely to developGISTs than whites.

glioblastoma—A fast growing andhighly malignant type of brain tumorarising from glial (supporting) cellswithin the brain. There are aboutfive to 10 new cases per millionpopulation per year in the UnitedStates, and the cause is unknown.

glioma—A type of brain tumor arisingfrom the supporting glial cells withinthe brain. Gliomas make up about60 percent of all primary brain tumorsand are frequently malignant.

graft-versus-host disease(GVHD)—A complication in bonemarrow transplants where immunesystem cells attack the transplantrecipient’s tissues.

head and neck cancer—The termgiven to a variety of malignant tumorsthat develop in the mouth, throat,paranasal sinuses, nasal cavity, larynx,and salivary glands. Many authori-ties also include skin tumors of theface and neck and tumors of the cer-vical lymph nodes. There are morethan half a million survivors of oral,head, and neck cancer living in theUnited States today.

hematological malignancies—Cancers of the blood or blood-forming tissues, such as leukemia,Hodgkin’s and non-Hodgkin’s lym-

phomas, AIDS-related malignancies,multiple myeloma, myelodysplasiaand myeloproliferative disorders.

hepatocellular cancer/carcinoma—A cancer that begins in the liver cells.

hyperuricemia—An abnormally highuric acid level in the blood.

imaging agent—A substance used toenhance x-ray images of organs andspaces in the body.

intraepithelial neoplasia, anal (AIN)& cervical (CIN)— AIN is a conse-quence of chronic human papillo-mavirus infection in the anal canaland appears to be driven by highviral loads of human papillomavirus.What is known of its natural historyresembles that of cervical intraep-ithelial neoplasia. Dysplasia and cer-vical intraepithelial neoplasia (CIN)are different terms or names for thesame condition—it is a precursor tocervical cancer. CIN may be mild,moderate or severe.

Kaposi’s sarcoma—A rare, malignantskin tumor that occurs in some AIDSpatients. It can be accompanied byfever, enlarged lymph nodes andgastro intestinal problems.

leiomyoma—A benign neoplasmderived from smooth muscle.

leukemia—A form of cancer in whichabnormally growing white blood cellsare scattered throughout the body andbone marrow. They can take over themarrow and prevent it from makingenough normal blood cells (white,red and platelets), leaving the patienthighly susceptible to serious infec-tions, anemia and bleeding episodes.The cells can also spill into the blood, infiltrating and interfering with thefunction of other organs. The fourmain types of leukemia are: acutelympho blastic leukemia (ALL), acute myeloid leukemia (AML), chroniclymphocytic leukemia (CLL), andchronic myeloid leukemia (CML).The acute types have a rapid onset,and overwhelming infection or bloodloss can cause death. The chronicforms progress much more slowly.

lung cancer—The leading cause of cancer deaths in both men and

G L O S S A R Y


women. There are several types oflung cancer, the most common beingsquamous cell carcinoma, small (oat)cell carcinoma, adenocarcinoma andlarge cell carcinoma. Each has a dif-ferent growth pattern and response totreatment. The squamous cell, smallcell and large cell types are all stronglyassociated with tobacco abuse.

lymphoma—Cancers in which thecells of lymphoid tissue, found mainlyin the lymph nodes and spleen, mul-tiply unchecked. Lymphomas fall intotwo categories: Hodgkin disease,characterized by a particular kindof abnormal cell, and non-Hodgkinlymphomas, which vary in theirmalignancy according to the natureand activity of the abnormal cells.Mantle cell lymphoma is a type ofnon-Hodgkin lymphoma.

macroglobulinemia—A disorder inwhich plasma cells produce anexcessive quantity of macroglobulins(large antibodies) that accumulate inthe blood. It results from a group ofabnormal, cancerous lymphocytesand plasma cells. Men are affectedmore often than women, and theaverage age at onset is 65.

mastocytosis—A condition charac-terized by infiltration of mast cellsinto the tissues of the body. Mastcells are connective tissue cellswhich release chemicals includinghistamine that are very irritating andcause itching, swelling, and fluidleakage from cells.

medullary—Relating to the medulla(any soft marrow-like structure, espe-cially the innermost part) or marrow.

melanoma—A cancer made up of pigmented (usually brown-colored)skin cells anywhere in the body.

mesothelioma—A tumor of the lining ofthe lung and chest cavity (the pleura).

metastases/metastatic—Areas ofsecondary cancer that have spreadfrom the primary or original cancersite.

mucositis—The swelling, irritation,and ulceration of the mucosal cellsthat line the digestive tract. Mucositis

can occur anywhere along the diges-tive tract from the mouth to the anus.It can be a very troublesome andpainful side effect of chemotherapy.

multiple myeloma—A malignantcondition of middle to old age,characterized by the uncontrolledproliferation and dis ordered functionof plasma cells in the bone marrow.The condition, which makes thepatient particularly prone to infection,is rare, with about three new casesannually per 100,000 population.

myeloablation—A severe form ofmyelosuppression, a condition inwhich bone marrow activity isdecreased, resulting in fewer redblood cells, white blood cells, andplatelets. It is a side effect of somecancer treatments.

myelodysplastic syndromes (MDS)—Blood disorders that ultimately arefatal. Patients usually succumb to infections or bleeding. The term“preleukemia” has been used todescribe these disorders.

neoadjuvant therapy—Chemo -therapy, radiation therapy, or hor-mone therapy given before theprimary or main treatment. Neo -adjuvant therapy, like chemotherapyand radiation therapy, is often givenbefore surgery to reduce the size ofa tumor or to make surgery lesscomplicated.

neuroblastoma—A tumor of theadrenal glands or sympathetic nerv-ous system (the part of the nervoussystem responsible for certain auto-matic body functions, such as thecontrol of heart rate). Neuro blastomasare the most common extracranial(outside the skull) solid tumors ofchildhood.

osteosarcoma—Cancer of the bonethat occurs predominantly in adoles-cents and young adults. It accountsfor 5 percent of cancer in children

peritoneal—Relating to the peri-toneum, the membrane that lines theabdominal cavity and covers most ofthe abdominal organs.

Phase 0—First-in-human trials con-ducted in accordance with FDA’s2006 guidance on exploratoryInvestigational New Drug (IND) stud-ies designed to speed up developmentof promising drugs by establishingvery early on whether the agentbehaves in human subjects as wasanticipated from preclinical studies.

Phase I—Safety testing and pharma -cological profiling of new drugs insmall numbers of humans.

Phase II—Effectiveness testing andidentification of side effects of newdrugs in humans.

Phase III—Extensive clinical trialsin humans to verify effectiveness and monitor adverse reactions of new drugs.

prolactinoma—A noncancerouspituitary tumor that produces a hor-mone called prolactin, which resultsin too much prolactin in the blood.

refractory—Resistant to treatment orcure.

sarcoma—A malignant tumor thatarises from deep body tissues, suchas muscle, bone or fibrous tissue.

T-cell—One of two main classes ofwhite blood cells called lymphocytes,which are important to the body’sdisease-fighting immune system.

thrombocytopenia—A reduction inthe number of platelet cells in theblood, which causes a tendency tobleed, especially from the smallerblood vessels.

thymoma—Although rare, thymomasare the most common tumor of thethymus, a small organ located in theupper chest just below the neck thatproduces certain types of white bloodcells (lymphocytes) before birth andduring childhood. Thymomas arisefrom thymic epithelial cells, whichmake up the covering of the thymus.Up to 40 percent of thymomas areinvasive. They affect men and womenequally and are usually diagnosedbetween the ages of 40 and 60.Thymomas are uncommon in children.

unresectable—Unable to beremoved (resected) by surgery.

G L O S S A R Y


S E L E C T E D F A C T S A B O U T C A N C E R I N T H EU N I T E D S T A T E SOverview1

• In 2008, more than 1.4 million new cancer cases are expected to be diagnosed. The National Cancer Institute estimatesthat approximately 10.1 million Americans with a history of cancer were alive in January 2002. The 5-year relativesurvival rate for all cancers diagnosed between 1996 and 2003 is 66 percent, up from 50 percent in the mid-70s.

• Men have a little less than a 1 in 2 lifetime risk of developing cancer, and for women, the risk is a little more than1 in 3. About 77 percent of all cancers are diagnosed in people ages 55 and older.

• Scientific evidence suggests that about one-third of the cancer deaths expected this year will be related to overweightor obesity, physical inactivity, and nutrition, and thus could be prevented.

• Cancer is the second leading cause of death by disease—1 of every 4 deaths—in the United States, exceeded onlyby heart disease. This year, an estimated 565,650 are expected to die of cancer, more than 1,500 people a day.

Costs1

• The National Institutes of Health estimate overall costs for cancer in 2007 at $219.2 billion: $89 billion fordirect medical costs (total of all health expenditures); $18.2 billion for indirect morbidity costs (e.g., cost of lostproductivity due to illness); and $112 billion for indirect mortality costs (cost of lost productivity due topremature death).

Bladder (Urinary) Cancer1

• Nearly 69,000 new cases of bladder cancer are expected in 2008. The incidence rate is nearly four times higher inmen than in women and almost two times higher in whites than in African Americans.

• Bladder cancer will cause more than 14,000 deaths in 2008. Mortality rates have continued to decrease sincethe late ‘70s, although the rate of decrease slowed in the most recent time period (0.2 percent a year from1987-2004 compared with 2.1 percent a year from 1977-1987).

Breast Cancer1

• After continuously increasing for more than two decades, female breast cancer incidence rates decreased by 3.5percent per year from 2001-2004. From 1992-2004, incidence rates decreased among American Indians/AlaskaNatives (1.5 percent per year) and did not change significantly among Asian Americans/Pacific Islanders orHispanics/Latinas.

• Death rates from breast cancer have steadily decreased in women since 1990, with larger decreases in womenyounger than age 50 (a decrease of 3.3 percent per year) than in those age 50 and older (2 percent per year).From 1995-2004, female breast cancer death rates declined by 2.4 percent per year in whites and Hispanics/Latinas,1.6 percent per year in African Americans, and remained unchanged among Asian Americans/Pacific Islandersand American Indians/Alaska Natives. The decrease in breast cancer death rates represents progress in bothearlier detection and improved treatment.

Cervical Cancer/Uterine (Endometrial) Cancer1

• An estimated 11,070 cases of invasive cervical cancer are expected to be diagnosed in 2008. Incidence rates havedecreased steadily over the past several decades in both white and African-American women. Mortality rates havealso declined steadily; an estimated 3,870 cervical cancer deaths are expected in 2008.

• More than 40,000 cases of cancer of the uterine corpus (body of the uterus), usually of the endometrium or liningof the uterus, are expected to be diagnosed in 2008.

Colorectal Cancer1

• An estimated 108,070 colon and 40,740 rectal cancer cases are expected to occur in 2008. Colorectal cancer isthe third most common cancer in men and women. More than 90 percent of colorectal cancer cases are diagnosedin people over age 50.


S E L E C T E D F A C T S A B O U T C A N C E R I N T H EU N I T E D S T A T E SColorectal Cancer1 (continued)

• Nearly 50,000 deaths from colorectal cancer are expected to occur this year, accounting for 9 percent of allcancer deaths. Mortality rates from colorectal cancer have declined in both men and women over the past twodecades with a steeper decline in the most recent time period (1.8 percent per year from 1985-2002 comparedto 4.7 percent from 2002-2004). That decrease reflects declining incidence rates and improvements in earlydetection and treatment.

Leukemia1

• An estimated 44,270 new leukemia cases are expected in 2008, with slightly more cases of chronic (19,940) thanacute (18,720) forms of the disease.

• Although often thought of as primarily a childhood disease, leukemia is diagnosed 10 times more often in adultsthan in children. Acute lymphocytic leukemia accounts for approximately 72 percent of the leukemia casesamong children. In adults, the most common types are acute myeloid leukemia (about 13,290 cases) andchronic lymphocytic leukemia (about 15,110 cases).

Lung Cancer1

• The estimated 215,020 new cases of lung cancer expected in 2008 will account for about 15 percent of cancerdiagnoses. The incidence rate is declining significantly in men, from a high of 102 cases per 100,000 in 1984 to73.6 in 2004. In women, the rate is approaching a plateau after a long period of increase.

• Lung cancer is the leading cause of cancer death in men and women. The estimated 161,840 deaths expectedthis year will account for about 29 percent of all cancer deaths. Death rates declined significantly in men from1991 to 2002 by about 1.9 percent per year. Since 1987, more women have died each year from lung cancerthan from breast cancer. Female lung cancer death rates are approaching a plateau after continuously increasingfor several decades, reflecting the decrease in smoking rates over the past 30 years.

Lymphoma1

• Of the estimated 74,340 new cases of lymphoma this year, 8,220 will be Hodgkin’s lymphoma and 66,120 will benon-Hodgkin’s lymphoma (NHL).

• Since the early 1970s, incidence rates for NHL have nearly doubled. Although some of this increase is due to AIDS-related NHL, for the most part, the rise is unexplained. Since 1991, increasing NHL incidence has been confined towomen.

• Over the past 30 years, incidence rates for Hodgkin’s lymphoma have decreased in men (0.7 percent per year)while they slightly increased in women (0.4 percent per year).

Ovarian Cancer1

• The estimated 21,650 new cases of ovarian cancer expected this year would account for about 3 percent of allcancers among women. It ranks second among gynecologic cancers, following cancer of the uterine corpus.

• Ovarian cancer causes more deaths than any other cancer of the female reproductive system—15,520 deaths areexpected in 2008.

Pain

• Most patients with cancer fear pain as their worst symptom. Indications are that 30 percent of those with newlydiagnosed cancer and 80 percent with previously diagnosed cancer have complaints of pain.2

• Studies have shown that 90 percent of patients with advanced cancer experience severe pain and that pain occursin 30 percent of all cancer patients, regardless of the stage of the disease. As many as 50 percent of patients maybe undertreated for cancer pain, yet not all cancer patients feel pain, and pain is rarely a sign of early cancer. Painusually increases as cancer progresses.3


S E L E C T E D F A C T S A B O U T C A N C E R I N T H EU N I T E D S T A T E SPain (continued)

• The most common cancer pain is from tumors that metastasize to the bone—as many as 60 percent to 80 percent ofcancer patients with bone metastasis experience pain. The second most common cancer pain is caused by tumorsinfiltrating the nerve and hollow viscus. Tumors near neural structures may cause the most severe pain. The thirdmost common pain associated with cancer occurs as a result of chemotherapy, radiation, or surgery. Cancer painalso may occur in different parts of the body. In one study, more than 80 percent of patients experienced twodistinct pains, and more than 30 percent experienced three distinct pains.3

• Fewer than half of cancer patients who experience pain receive adequate treatment for their pain. More than half ofall hospitalized patients experienced pain in the last days of their lives, and although therapies are present toalleviate most pain for those dying of cancer, research shows that 50 percent to 75 percent of patients die inmoderate to severe pain.4

• African Americans and Hispanics are affected by racial profiling for diversion and under-treatment for pain by somephysicians. This is compounded by a lack of research on pain across racial and ethnic differences as well ascultural attitudes toward pain care. One study found that more than 80 percent of African-American patients and80 percent of Hispanic patients waited until their pain severity was a 10 on a 10-point scale before calling theirhealthcare provider or oncology clinic for assistance with pain management.4

• Chronic pain has been said to be the most costly health problem in America. Estimated annual costs, includingdirect medical expenses, lost income, lost productivity, compensation payments, and legal charges, are about$90 billion.5

Pancreatic Cancer1

• Nearly 38,000 new cases of pancreatic cancer are expected to occur in the United States in 2008. Incidence ratesof pancreatic cancer have been stable in men since 1993 and in women since 1983.

• More than 34,000 deaths from pancreatic cancer are expected this year. The death rate has continued to declinesince 1975 in men, while it has leveled off in women after increasing from 1975-1984.

Prostate Cancer1

• Prostate cancer is the most frequently diagnosed cancer in men—more than 186,000 new cases will be diagnosedin 2008. Incidence rates are significantly higher in African-American men than in white men. Rates peaked in whitemen in 1992 (237.8 per 100,000 men) and in African-American men in 1993 (343.1 per 100,000 men).

• Prostate cancer is a leading cause of cancer death in men, and an estimated 28,660 are expected to die thisyear. Although death rates have decreased more rapidly among African-American men than among white mensince the early 1990s, rates in African-American men still remain more than twice as high as those in white men.

Skin Cancer1

• The most serious form of skin cancer is melanoma, which is expected to be diagnosed in more than 62,000 peoplein 2008. During the 1970s, the incidence rate for melanoma increased rapidly by about 6 percent annually. From1981-2000, the rate of increase slowed to 3 percent per year, and since 2000, melanoma incidence has beenstable. Melanoma is primarily a disease of whites—rates are more than 10 times higher in whites than in AfricanAmericans.

• Skin cancer will cause more than 11,000 deaths in 2008—8,420 from melanoma and 2,780 from othernonepithelial skin cancers. The death rate for melanoma has been decreasing rapidly in whites younger than age50, by 3 percent a year since 1991 in men and by 2.3 percent a year since 1985 in women. In those older thanage 50, rates have been stable since 1998 in men and since 1990 in women.


S E L E C T E D F A C T S A B O U T C A N C E R I N T H EU N I T E D S T A T E SNew Cancer Cases/Deaths 1

Cancer Type Estimated 2008 New Cases Estimated 2008 Deaths

All Sites 1,437,180 565,650Male 745,180 294,120Female 692,000 271,530

Acute Lymphocytic Leukemia 5,430 1,460Male 3,220 800Female 2,210 660

Acute Myeloid Leukemia 13,290 8,820Male 7,200 5,100Female 6,090 3,720

Bladder Cancer 68,810 14,100Male 51,230 9,950Female 17,580 4,150

Bone Cancer (and joints) 2,380 1,470Male 1,270 820Female 1,110 650

Brain Cancer (and other nervous system) 21,810 13,070Male 11,780 7,420Female 10,030 5,650

Breast Cancer 184,450 40,930Male 1,990 450Female 182,460 40,480

Cervical Cancer/Uterine Cancer 51,170 11,340Male — —Female 51,170 11,340

Chronic Lymphocytic Leukemia 15,110 4,390Male 8,750 2,600Female 6,360 1,790

Chronic Myeloid Leukemia 4,830 450Male 2,800 200Female 2,030 250

Colorectal Cancer 148,810 49,960Male 77,250 24,260Female 71,560 25,700

Esophageal Cancer 16,470 14,280Male 12,970 11,250Female 3,500 3,030


S E L E C T E D F A C T S A B O U T C A N C E R I N T H EU N I T E D S T A T E SNew Cancer Cases/Deaths 1 (continued)

Cancer Type Estimated 2008 New Cases Estimated 2008 Deaths

Kidney Cancer (and renal pelvis) 54,390 13,010Male 33,130 8,100Female 21,260 4,910

Leukemia (all types) 44,270 21,710Male 25,180 12,460Female 19,090 9,250

Liver Cancer 21,370 18,410Male 15,190 12,570Female 6,180 5,840

Lung Cancer (and bronchus) 215,020 161,840Male 114,690 90,810Female 100,330 71,030

Lymphoma (all types) 74,340 20,510Male 39,850 10,490Female 34,490 10,020

Lymphoma (non-Hodgkin’s) 66,120 19,160Male 35,450 9,790Female 30,670 9,370

Melanoma-Skin Cancer 62,480 8,420Male 34,950 5,400Female 27,530 3,020

Multiple Myeloma 19,920 10,690Male 11,190 5,640Female 8,730 5,050

Ovarian Cancer 21,650 15,520Male — —Female 21,650 15,520

Pancreatic Cancer 37,680 34,290Male 18,770 17,500Female 18,910 16,790

Prostate Cancer 186,320 28,660Male 186,320 28,660Female — —

Stomach Cancer 21,500 10,880Male 13,190 6,450Female 8,310 4,430


S E L E C T E D F A C T S A B O U T C A N C E R I N T H EU N I T E D S T A T E SSources:1. Cancer Facts & Figures 2008, American Cancer Society (www.cancer.org)2. Journal of the American Osteopathic Association (www.jaoa.org)3. Oncology Channel® (www.oncologychannel.com)4. American Pain Foundation (www. painfoundation.org)5. Oregon Health and Science University (www.ohsu.edu)


T H E D R U G D I S C O V E R Y , D E V E L O P M E N T A N D A P P R O V A L P R O C E S SIt takes 10-15 years on average for an experimental drug to travel from the lab to U.S. patients. Only five in 5,000compounds that enter preclinical testing make it to human testing. One of these five tested in people is approved.

The U.S. system of new drug approvals is perhapsthe most rigorous in the world.

It takes 10-15 years, on average, for an experimentaldrug to travel from lab to U.S. patients, according tothe Tufts Center for the Study of Drug Development,based on drugs approved from 1994 through 1998.Only five in 5,000 compounds that enter preclinicaltesting make it to human testing. And only one of thosefive is approved for sale.

On average, it costs a company $1.3 billion to getone new medicine from the laboratory to U.S. patients,according to a 2007 study by the Tufts Center for theStudy of Drug Development.

Once a new compound has been identified in thelaboratory, medicines are developed as follows:

Preclinical Testing. A pharmaceutical company con -ducts laboratory and animal studies to show biologicalactivity of the compound against the targeted disease,and the compound is evaluated for safety.

Investigational New Drug Application (IND). Aftercompleting preclinical testing, a company files an INDwith the U.S. Food and Drug Administration (FDA) tobegin to test the drug in people. The IND becomeseffective if FDA does not disapprove it within 30 days.The IND shows results of previous experiments; how,where and by whom the new studies will be conducted;the chemical structure of the compound; how it isthought to work in the body; any toxic effects foundin the animal studies; and how the compound is man -ufactured. All clinical trials must be reviewed andapproved by the Institutional Review Board (IRB)where the trials will be conducted. Progress reportson clinical trials must be submitted at least annuallyto FDA and the IRB.

Clinical Trials, Phase I. These tests involve about 20to 100 normal, healthy volunteers. The tests study adrug’s safety profile, including the safe dosage range.The studies also determine how a drug is absorbed,distributed, metabolized, and excreted as well as theduration of its action.

Clinical Trials, Phase II. In this phase, controlledtrials of approximately 100 to 500 volunteer patients(people with the disease) assess a drug’s effectiveness.

Clinical Trials, Phase III. This phase usually involves1,000 to 5,000 patients in clinics and hospitals.Physicians monitor patients closely to confirm efficacyand identify adverse events.

New Drug Application (NDA)/Biologic LicenseApplication (BLA). Following the completion of allthree phases of clinical trials, a company analyzes allof the data and files an NDA or BLA with FDA if thedata successfully demonstrate both safety and effec -tiveness. The applications contain all of the scientificinformation that the company has gathered.Applications typically run 100,000 pages or more.The average review time for the 24 new therapeuticsapproved by the FDA in 2008 was 17.8 months.

Approval. Once FDA approves an NDA or BLA, thenew medicine becomes available for physicians toprescribe. A company must continue to submit periodicreports to FDA, including any cases of adverse reactionsand appropriate quality-control records. For somemedicines, FDA requires additional trials (Phase IV) toevaluate long-term effects.

Discovering and developing safe and effective newmedicines is a long, difficult, and expensive process.Pharmaceutical companies invested an estimated$65.2 billion in research and development in 2008.

Clinical Trials

Discovery/ Phase Phase Phase PhasePreclinical Testing I II III FDA IV

Years

TestPopulation

Purpose

SuccessRate

6.5

Laboratory andanimal studies

Assess safety,biological

activity andformulations

5,000compounds evaluated

1.5

20 to 100healthy

volunteers

Determinesafetyand

dosage

2

100 to 500patient

volunteers

Evaluateeffectiveness,

look forside effects

1.5

Reviewprocess/approval

1approved

Additionalpost-

marketingtesting

requiredby FDA

3.5

1,000 to 5,000patient

volunteers

Confirm effectiveness,monitor adverse reactions from long-term use

5enter trials

File

IND

at F

DA

File

ND

A/BL

A at

FD

A

T H E D R U G D E V E L O P M E N T A N D A P P R O V A L P R O C E S S

New Medicines. New Hope.®

Pharmaceutical Research and Manufacturers of America950 F Street, NWWashington, DC 20004

www.phrma.org | www.innovation.org | www.pparx.org | www.buysafedrugs.info | www.sharingmiracles.com 4/09

Medicines in Development for Cancer is presented by PhRMA in cooperation with the following organizations:

Being listed in this report in no way implies that the above-mentioned organizations endorse or recommendthe use of any of the products in development contained in this publication. For further information, patientsshould consult their physicians or health care providers.

American Brain Tumor AssociationAmerican Nurses AssociationAssociation of Community Cancer CentersBurger King Cancer Caring CenterChemotherapy FoundationOncology Nursing SocietyPAACT (Patient Advocates for Advanced

Cancer Treatments)

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