Ozone TherapyOzone Therapy

Kastner-PraxisbedarfGmbHMedizintechnikGermany

new dimension innew dimension in

O2O O3

1. Cosma F. Andreula, Luigi Simonetti, Fabio de Santis, Raffaele Agati, Renata Ricci, and Marco Leonardi, Minimally Invasive Oxygen-Ozone Therapy for Lumbar Disc Herniation, AJNR Am J Neuroradiol 24:9961000, May 2003

2. Muto M, Avella F. Percutaneous treatment of herniated lumbar disc by intradiscal oxygen-ozone injection. Intervent Neuroradiol 1998;4:2792863. Iliakis E. Ozone treatment in low back pain. Orthopaedics 1995; 1:29 334. Viebahn R. The Use of Ozone in Medicine. Heidelberg: Karl F. Haug Publisher; 1994 5. Iliakis E, Valadakis V, Vynios DH, Tisiganos CP, Agapitos E. Rationalization of the activity of medical ozone on intervertebral disc: a histological and biochemical study. Riv Neuroradiol

2001;14 (suppl 1):2330 6. Bocci V. Oxygen-Ozone Therapy, a Critical Evaluation. Doordrecht: Kluwer Academic Publishers; 20027. Bocci V, Luzzi E, Corradeschi F, et al. Studies on the biological effects of ozone: III, an attempt to define conditions for optimal induction of cytokines. Lymphokine Cytokine Res

1993;12:1211268. Andreula CF. Lumbosacral disc herniation and correlated degenerative disease: spinal interventional chemodiscolysis with O3. Riv Neuroradiol 2001;14(suppl 1):81889. Rilling S, Viebahn R. The Use of Ozone in Medicine. 2nd ed. Heidelberg: Karl F. Haug Publisher; 1987:718710. Bocci V. Autohaemotherapy after treatment of blood with ozone: a reappraisal. J Int Res 1994;22:131144 11. Coppola L, Verazzo G, Giuta R, et al. Oxygen-ozone therapy and hemorrheological parameters in peripheral chronic arterial occlusive disease. Trombosi e Aterosclerosi 1992;3:858912. Rokitansky O, Rokitansky A, Steiner J, et al. Ozontherapie bei peripheren, arteriellen. Durchblutungsstorungen: klinik, biochemishe und blutgasanalytische untersuchungen. In:

Oxygen-ozone therapyOxygen-ozone therapy exploits the chemical properties of ozone, an unstable allotropic form of oxygen with the symbol O3 and a molecular weight of 48 kDa. Many biologic effects have been attributed to ozone: increased glycolysis; effects on red blood cells; effects on rheology; bactericidal, fungicidal, and virucidal ; immunomodulating action; and analgesic and anti-inflammatory effects. This broad spectrum of action explains the many indications for medical ozone administration. In oxygen-ozone therapy, medical ozone is administered in the form of an oxygen-ozone gas mixture, at nontoxic concentrations varying from 1 to 40 µg of ozone per milliliter of oxygen.

Empirical studies performed in vivo on rabbits and in vitro on resected human disc specimens have demonstrated that for intradiscal administration the optimal concentration of ozone per milliliter of oxygen is 25-30 µg. At this concentration, ozone has a direct effect on the proteoglycans composing the disc's nucleus pulposus, resulting in its release of water molecules and subsequent cell degeneration of the matrix, which is replaced by fibrous tissues in the space of 5 weeks and the formation of new blood cells. Together, these events result in the reduction of disc volume.

In five histologic disc specimens removed during surgical microdiscectomy from patients who had received intradiscal injections of medical ozone at a concentration of 25-30 µg, dehydration of the fibrillary matrix of the nucleus pulposus, revealing collagen fibers and signs of regression (vacuole formation and fragmentation)a sort of disc “mummification” was noted.

A reduction in herniated disc volume is one of the therapeutic motives for intradiscal administration of medical ozone, as a reduction in disc size reduces nerve root compression. Disc shrinkage may also help to reduce venous stasis caused by disc compression of vessels, thereby improving local microcirculation and increasing the supply of oxygen. This has a positive effect on pain as the nerve roots are sensitive to hypoxia. Another reason for using medical ozone to treat disc herniation is its analgesic and anti inflammatory effects, which may counteract disc-induced pain.

CT measurements of L4-L5 disc herniation Correct positioning of the needle. Distribution of the gas mixture.

Minimally Invasive Oxygen-Ozone Therapy for Lumbar Disc Herniation

BIBLIOGRAPHY

Courtesy : Matteo Bonetti, Alessandro Fontana, Biagio Cotticelli, Giorgio Dalla Volta, Massimiliano Guindani, and Marco Leonardi Intraforaminal O2-O3 versus Periradicular Steroidal Infiltrations in Lower Back Pain: Randomized Controlled Study, AJNR Am J Neuroradiol 26:9961000, May 2005

Results from short-, medium- and long-term follow-up

Follow-Up and Patients

Outcome with O-O2 Outcome with Steroid3

Excellent Good Poor Excellent Good Poor

Short term

With disk disease ( n 166) 73 (84.8%) 8 (9.3%) 5 (5.9%) 64 (80%) 10 (12.5%) 8 (10%)

Without disk disease ( n 160) 56 (80%) 11 (15.7%) 3 (4.3%) 55 (78.5%) 9 (12.8%) 5 (7.2%)

Medium term

With disk disease ( n 166) 67 (77.9%) 9 (10.5%) 10 (11.6%) 54 (67.5%) 14 (17.5%) 12 (15%)

Without disk disease ( n 160) 55 (78.5%) 9 (12.9%) 6 (8.6%) 49 (70%) 10 (14.2%) 11 (15.8%)

Long term

With disk disease ( n 166) 64 (74.4%) 9 (10.5%) 13 (15.1%) 46 (57.5%) 16 (20%) 18 (22.5%)

Without disk disease ( n 160) 53 (75.8%) 11 (15.7%) 6 (8.6%) 44 (62.8%) 11 (15.8%) 15 (21.4%)

Note.—Data in parentheses are percentages. Short term 1 week, medium term 3 months, and long term 6 months.

Oxygen-ozone therapy for Wound Management

Wasser, IOA, ed. Ozon-Weltkongress. Berlin: 1981:537513. Wenzel DG, Morgan DL. Interactions of ozone and antineoplastic drugs on rat lung fibroblasts and Walker rat carcinoma cells. Res Commun Chem Pathol Pharmacol 1983;40:27928714. Matteo Bonetti, Alessandro Fontana, Biagio Cotticelli, Giorgio Dalla Volta, Massimiliano Guindani, and Marco Leonardi Intraforaminal O2-O3 versus Periradicular Steroidal Infiltrations

in Lower Back Pain: Randomized Controlled Study, AJNR Am J Neuroradiol 26:9961000, May 2005 15. Fabris G, Tommasini Gl. Percutaneous treatment of lumbar herniated disc. 10 years of experience in Udine. Rivista di Neuroradiologia 1997;10:52353216. Buckley R. D., Hackney J. D., Clark K,. Posin C. - Arch. Environ Health/Vol. 30 gen. 1975 pp. 40-43 OZONE AND HUMAN BLOOD17. Beck E. G. - Acta Toxicol. Ther., Vol. XVII n. 2-3, 1996 OZONE IN PREVENTIVE MEDICINE, Riva Sanseverino E. - 20 Congr. Internaz. Dusseldorf 16/19.11.198818. Jucopilla N., Franzini M. TREATMENT OF GONARTHROSIS BY OXYGEN-OZONE LOCAL THERAPY, - Atti 1 Congresso 29/30.06.1995 Barcellona-1 Congresso de la Sociedad

Espanola de abordajes percutaneos vertebrales19. Dyas A, Boughton B, Das B 1983 Ozone killing action against bacterial and fungal species. Journal of Clinical Pathology 36(10):1102-1104 20. Werkmeister H 1985 Subatmospheric 02/03 treatment of therapy-resistant wounds and ulcerations. OzoNachrichten 4:53-59 Gregorio Martínez-Sánchez, Saied M. Al-Dalain, Silvia

Menéndez, Lamberto Re,

21. Attilia Giuliani, Eduardo Candelario-Jalil, Hector Álvarez, José Ignacio Fernández-Montequín, Olga Sonia León, Therapeutic efficacy of ozone in patients with diabetic foot, European Journal of Pharmacology 523 (2005) 151161

BIBLIOGRAPHY

Some Results of Ozone Disc Nucleolysis

Measurement of the area and perimeter of the lesions, at the beginning and at the

end of the study, the variation in both parameters with time, as well as theexpected total recovery for both groups

Parameter Start (X±SD) End (X±SD)

Area

(cm2)

Antibiotic n( =49) 54.84±0.39 40.72±0.35

Ozone n( =51) 57.97±0.52 23.31±0.36

pa 0.687 0.017

Perimeter

(cm)

Antibiotic n( =49) 21.49±0.11 17.34±0.14

Ozone n( =51) 18.49±0.14 12.62±0.13

pa 0.063 0.004

Control n( =49) Ozone (n=51)

Area

reduction(%)

% 50.30±0,17 74.58±0.35

pb 0.017

Perimeter

reduction

(%)

% 26.63±0.17 41.52±0.25

pb 0.000

Healing

rate with

respect

to area(cm2/days)

X±SD 1.21±0.01 2.66±0.05

pb 0.005

Healing

rate withrespect

to

perimeter

(cm/days)

X±SD 0.24±0.00 0.34±0.00

pb 0.040

Expected

total

recovery

(days)

X

a

±SD 45±11 21±10

pb 0.002

The pharmacodynamic effect of ozone in the treatment of patients with infectious wounds can be ascribed to the possibility of it being a superoxide scavenger. By virtue of its extremely high bacteriocidal, fungicidal & sporicidal potential ozone reduces the microbial load in the wound bed. The toxin load is reduced and the wound heals faster.

Attilia Giuliani, Eduardo Candelario-Jalil, Hector Álvarez, José Ignacio Fernández-Montequín, Olga Sonia León, Therapeutic efficacy of ozone in patients with diabetic foot, European Journal of Pharmacology 523 (2005) 151161

Some Results

Basic: The Portable Ozone unit for syringe appication

! Easy and safe use through icon driven operating panel

! Precise and reliable ozone concentration between 0 to 80 µg/ml

by photometric ozone calibration

! Compact and space saving design for flexible and mobile use

! Ideal for

Technical data:

! Table top model, dimensions: 310 x 290 x 110 mm, weight: 4.2

kgs

! Ozone concentration: 0 - 80 µg/ml

! Electrical data: 220 - 240V, 50 - 60 cycles, 100 VA, Protection

class I, Type B

! CE certified: CE0368

syringe based intra discal, intra muscular Ozone therapy

Smartline : The universal ozone device

!

! Precise and reliable ozone concentration between 0 to 80µg/ml by photometric ozone calibration

! Concentration increased in steps of 1 microgram/ ml

! S

! Fully automated processes for all possible ozone applications like extra corporeal blood treatment (major & minor autohemotherapy), rectal ozone gas insufflation with permanent

! Vacuum function for topical applications like skin, suction bag treatment

! Separate valves for hygienic transcutaneous gas bath (suction bag and suction cup) and water ozonization

Technical data:

Easy and safe use through touch screen driven operations

yringe based intra discal, intra muscular Ozone therapy

monitoring of concentration, total insufflated volume and total insufflated ozone concentration, adjustable water-ozone device

! Table top model, 425 x 390 x 170 mm, 12.2 kg

! Ozone concentration: 0 - 80 µg / ml, in steps of 1 µg / ml

! Electrical data: 220 - 240 V, protection class I, Type B

! CE certified according to 93/42/EEC: CE 0483, class IIa

THERAPEUTIC APPLICATIONS OF OZONE! Syringe applications (intradiscal, intramuscular, subcutaneous, intra-articular etc.)

! Topical applications, such as suction bag and suction cup treatments

! Extra corporeal blood treatment (major and minor autohemotherapy)

! Rectal ozone gas insufflation

BASIC SMARTLINE

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