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OVERVIEWCELLULAR AND

MOLECULAR

NUTRITION

DEPARTEMEN GIZI MASYARAKAT

FEMA IPB

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WHY CELLULAR AND MOLECULAR

NUTRITION?

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DEFINITION

Science concerned with the effect of nutrients andfoods/food components on whole body physiology

and health status at a molecular and cellular level.

molecular mechanisms underlying human health

and disease offers a great potential for promotinghealth, and lowering mortality and morbidity, and

includes the science of nutrigenomics

(Norheimet al.

2012).

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MOLECULAR AND CELLULLAR EFFECT OF

VIT E

AngeloAzzi’s group (1991) first described nonantioxidant, cell signaling

functions for vitamin E, demonstrating that vitamin E regulate protein

kinase C activity in smooth muscle cells.

At the transcriptional level, vitamin E modulates the expression of the

hepatic a-tocopherol transfer protein (TTP)

 as well as the expression collagenase gene and a-tropomyosin gene

a tocopherol-dependent transcription factor (tocopherol associated

protein, TAP) has been discovered.

In cultured cells, t vitamin E inhibits inflammation, cell adhesion, platelet

aggregation, and smooth muscle cell proliferation.

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Rimbach et al. (2005).

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DIET - PHENOTYPE

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EXPERIMENTAL VS NON-EXPERIMENTAL STUDIES

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DESKRIPSI MK GIZI SELLULER DAN

MOLEKULER

Membahas sel sebagai unit fungsional terkecil tubuh

manusia, komunikasi inter dan antar sel, regulasi hormon

dan enzim, mekanisme transpor, metabolisme di tingkat

seluler, replikasi, transkripsi serta ekspresi gen yangdipengaruhi oleh peran molekul zat gizi.

Mata kuliah ini juga membahas teknik penelitian dan

prinsip pengukuran di tingkat seluler dan molekuler

beserta contoh aplikasinya.

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PUSTAKA

Norheim et al. 2012. Review: Molecular Nutrition Research — The

Modern Way Of Performing Nutritional Science. Nutrients : 2012 (4),

1898-1944; doi:10.3390/nu4121898.

Advanced Nutrition and Human Metabolism, fourth Edition,

Gropper/Smith/Groff, Thompson-Wadsworth, 2005. Understanding Nutrition, Ninth Edition, Whitney/Rolfes, Wadsworth,

2002