Phase I Trial Designs Jud Blatchford, PhD BIOM 6649 – Clinical Trials April 9 th, 2015.
Overdose deaths following prison release in Norway · Mortality rate: weeks following release...
Transcript of Overdose deaths following prison release in Norway · Mortality rate: weeks following release...
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Overdose deaths following prison release in Norway
Thomas Clausen Professor (Dr. med)
29. September 2016
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Inmates with opioid dependence – a particularly vulnerable group
High rates of overdose deaths
post release
– Loss of tolerance
– High risk of overdose first 4 weeks
– Polydrug increases risk
– Inmates from «drug» unites at highest risk post release
Kilde: Merall et al, Addiction (2010)
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What characterizes inmates? Norway
Project aim; visit all prisons and invite all inmates to participate – Data collection during 2013-14
– Included 57 out of 63 prison-units nationally
1499 included inmates, including 96 women Mean age 34.5 yrs
2/3 born in Norway
2/3 living alone/single
56% with previous convictions/inmate experience
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Inmates: Lifetime prevalence of drug use by gender. (%)
65%; lifetime experience with drug use
Similar for both genders
90% of those with drug use experience had experience with 2 or more drugs, and 45% experience with 10 or more drugs
Male Female
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Mean age at first use, by gender, %
Lowest age at first use for cannabis and inhalants (16 yrs).
Mean age for first use of amphetamines -18 yrs, and for heroin 21 years
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Daily use of drugs six months prior to prison, by gender (%)
Around 50% had used one or more drugs daily six months prior to imprisonment
Among those with daily drug use prior to imprisonment; 80% had prior convictions and 53% had experience with injecting drugs
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Experience with drug use during imprisonment, by gender (%)
A total of 35% had experience with drug use during current or previous imprisonment
Inmates with drug use experience during imprisonment; a highly selected group:
• 86% previously convicted
• 87 % had used drugs daily 6 months prior to imprisonment
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Summary: A high prevalence of drug use problems among inmates
• 65 % with drug use experience
– Most had experience with multiple drugs
• Around 50% had daily use of drugs six months prior to imprisonment
• Between 10-15% had used opioids daily
• Around 50% had been intoxicated during crime that caused imprisonment
• Around 50% had a drug-related conviction
• 35% had experience with drug use while in prison
http://www.med.uio.no/klinmed/forskning/sentre/seraf/publikasjoner/rapporter/2016/nedlastinger/seraf-rapport-nr-2-2016-rusmiddelbruk-og-helsesituasjon-blant-innsatte.pdf
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Norwegian prison release project
Prison database – Including dates of release
– Data from 2000-2014
– More than 150.000 releases
– More than 90.000 persons
Linkage with GMR data, with all cause mortality
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Mortality rate: weeks following release
Previous research since 1990s
Ingrid A. Binswanger, MD, MPH; Patrick J. Blatchford, PhD; Shane R. Mueller, MSW; and Marc F. Stern, MD: Mortality After Prison Release:
Opioid Overdose and Other Causes of Death, Risk Factors, and Time Trends From 1999 to 2009. Ann Intern Med. 2013;159(9):592-600.
doi:10.7326/0003-4819-159-9-201311050-00005
.
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Overdose deaths and OMT; Norway
Burden of disease report 2016; Norway; FHI
Overdose deaths
Numbers in OMT
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Number of overdoses
Timing of data collection
Project period
2000 - 2014
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Conclusions
Inmates in Norwegian prisons are a group with high prevalence of drug problems
Many who are imprisoned, have used drugs regularly prior to imprisonment; and many of these also use drugs while in prison
We observe an immediate high risk of overdose death following release, with gradual decrease in risk over the first month
We recommend high treatment (OMT) availability both inside and outside of prisons
We recommend well planned prison releases; including planned treatment and health care transfers/ follow up; starting on day 0