Osteoarthritis Treatment | Stem Cell Treatment for Osteoarthritis
Osteoarthritis
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Transcript of Osteoarthritis
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SECONDARY OA: Appears at any age in a previously damaged or congenitally abnormal joint . OA is a “wear and tear” phenomenon. Indeed the vertebrae , hips and knees are most affected . OA can be superimposed upon RHEUMATOID ARTHRITIS.
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Two main theories:1)BIOMECHANICAL THEORY2)BIOCHEMICAL THEORY
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This maintains the wear and tear leads to deranged function,focal death, and reactive proliferation of chondrocytes.
Collagen breakdown , fissuring and flaking and osteophyte formation occurs.
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maintains that aging leads to lessened matrix maintenance and excess of lytic enzymes , which in turns lead to synovitis . Synovitis further results in a release of inflammatory mediators and cytokines(especially IL-1) , degradative enzymes and free radicals and eventually chondrocyte death.
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Primary abnormality is thinning and fragmentation of the articular cartilage.
Loss of articular cartilage leads to exposure of subchondral bone , which appears as shiny foci on the articular surface( enburnation ).
New bone formation , usually in the form of nodules (spurs).
Formation of osteocartilagenous loose bodies (“joint mice”).
Inflammation is absent.
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CLINICAL FEATURES:Although OA may be
asymptomatic,most patients experience morning stiffness in affected joints . There is usually no local heat or tenderness , but affected joints often show restricted range of motion , small efusions and crepitus. A slowly progressive disease characterized by joint disability.It is associated with ALKAPTONUREA and FOOTBALL PLAYERS.
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OSTEOARTHRITIS IN KNEE JOINT.
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OSTEOARTHRITIS.
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