Open Source Malaria/TB Update

A/Prof Matthew Todd, School of Chemistry, University of Sydney

mattoddchem

http://intermolecular.wordpress.com/

OSP2, Marburg, Aug 31-Sept 3 2015

Matthew Todd

http://www3.imperial.ac.uk/schisto; http://bit.ly/9azFHv

Open Project #1: Bilharzia2/12

Completed Open Solution

Details of Route: PLoS NTD 2011, 5(9): e1260 Full Description of Project: Nature Chemistry 2011, 3, 745-748

3/12

Open Source Malaria 4/12

http://www.thesynapticleap.org/node/343

Landing page:http://opensourcemalaria.org

OSM Series Summary 5/12

http://openwetware.org/wiki/OpenSourceMalaria:Compound_Series

Series typically not exhausted - Decision points made to move to another.Anyone free to employ OSM infrastructure to explore these series

Inputs on Data/Visualisation 6/12

With

With Luc Patiny

Inputs on Strategy 7/12

Writing 8/12

OSTB – Series 2 – The Hit9/12

GSK Tres Cantos, J. Overington and M. Marti-Renom, Unpublished 2014

Predicted Targets:

1) O06266 (an epoxide hydrolase)2) A2VJ47 (an epoxide hydrolase ephB)3) P64411 (Heat shock protein 90)4) P96222 (Mtb HTH-type transcriptional regulator Eth)

Is Open Source Drug Discovery Realistic?10/12

http://www.fda.gov/scienceresearch/specialtopics/criticalpathinitiative/criticalpathopportunitiesreports/ucm077262.htm

100% Obvious 29% Obvious89% Obvious

Break a Monolithic Structure11/12

Reconstruct12/12

Nimble, self-assembly encouraged through openness

26/26

Open AccessContent may be viewed freely without charge to the reader.

Open InnovationProblems are posted openly, solutions can be closed/private.Significant level of ownership of result.

CrowdsourcingA group completes a task by individuals completing small fragments. No requirement for methods/details to be shared.Gain: Person-power

Open SourceAll data and ideas are shared openly (i.e. with everyone), anyone may contribute at any level.All content may be remixed and reused.No consortia, restrictions, embargoes, minimal ownership.Gain: Lack of (unnecessary) duplication