73

　　　　　　　　　　　　　　　　　　　Original Articles

　　　　　　　　　　　　　　　　　　　　　　(Abstract)

　　　　　　　　　　　　　Longitudinal Pigmented stripe in the Nail*

　　　　　　　　　　　　　　　　　　　　　　　　by

　　　　　　　　　　　Akira Shiratori, Tadahiro Takada and Juro Goto**

　　A 16-year-old boy was firstobserved in July, 1957. He had firstnoticed ａ fine brown-

ish-black longitudinal stripe at the base of the nail of the left fourth finger in 1953.

This gradually progressed to the distal margin. grew deeper, and during following few

years identical pigmented stripes appeared in all fingernails except for the left fifthｏｎｅ。

He had never had ａ pigmented mole in any other part of his body. His nails had always

･developed normally.　　　　　　　　　　　　　　　　　　　　｀

　　Findings on physical examination were essentially normal, except for brownish-black

pigmented stripes in the fingernails.　These were various in width and deepness of color.

extending from the base of each nail to its free edge (Fig.　1 and 2）.

　　Microscopic sections of the nail showed pigment granules in the nail cellscorresponding

in extent and position to the area of the pigmented stripe. They were scattered throughout

the entire thickness of the nail. with a tendency to be more dense in deeper layers than

in the superficial.

　　The family history revealed that his father and two elder sisters have had similar

pigmented nails (Tab. 1）.

　　The mass examination of 1,826 persons lead the authors to the following conclusions :

　　1) Longitudinal pigmented stripes in the nail were found in 1.6% (male 1.3%, female

2.2%) of apparently normal persons (Tab. 2).

　　2）Ｔｈｅ frequency.of appearance of the pigmented stripe was found to be high in the

following descending order；　thefirst.the second, the third. the fourth and the fifth finger

(Tab. 3). This finding would indicate that there ｅχistsa resembrance in distribution

between the pigmented stripe in the nail and ephelides inversae Siemens.

　　3) There might be no papers reporting family occurrence in the literature, except for

the ａｂｏ▽ｅmentioned case. and there was also no family history of ａ similar pigmented

nail in the cases observed in our mass examination.

　　4) Persons with pigmented nails were not so mach pigmented in other part of the

body (Tab. 4）.

　＊　Full-lengthreport: Japanese section pp. 399～404

＊＊　Department of Dermatology (Director: Prof. Yusho Miura), Facu!ty of Medicine, University of

　　　Hokkaido, Sapporo

74

The Effect of Ｐ３２on the Function of the Reticuloendothelial

　　　　　　　System in Rabbits with Late Syphilis*

　　　　　　　　　　　　　　　　　　by

　　　　　　　　　　　　　　YaichiＴｓｕｂａｋｉ“

　　As the distribution of radioisotope Ｐ３２within the body closely resembled that of

treponema pallidum, Miura et a1. assumed that administration of P32 to patients afHicted

with incurable latent syphilis would develop　biotropisme　of　treponema　pallidum　by

its radioactivity, and the antiluetic treatment instituted ｏχlthis (jccasion would lead to the

cure of syphilis.　It was proved clinically and experimentally in animals that the antibody

titer became unstable after administration of p32 but the mechanism of this phenomenon

is still obscure｡

　　Considering the theory that the production of antibodies mainly relies on the function

of the r゙eticuloendothelial system. Tanaka's modification of Oh's chicken erythrocyte

phagocytic test was applied to examine the effect of p32 on the function of reticuloendo-

thelial system in rabbits with late syphilis｡

　　Experimental material :

　　Nichols, Tani or Kojimachi strains of treponema pallidum were innoculated into the

testis of rabbits 助d those that had ａ positive luetic reaction after 100 days or more were

subjected to the experiment. P32 was prepared in the form of H3P32O4 C15A-P in the catalogue

of AEC) and Ca45 ａｓ万Ca≪C12 (P-2, Oak Ridge National Laboratory) and stored in ampoules.

each containing l me in 2 cc of distaied water aT1万dwere sterilized before the administration｡

　　The results of the experiments are as follows :

　　1)Ｔｈｅ chicken erythrocyte phagocytic function was tested in 3 rabbits with late

syphilis and the test was performed once daily for 5 days in succession ； the vanishing

of chicken erythrocytes occurred at ａ minimum time of one hour 45 minutes and at ａ

maximum time of ３ hours 30 minutes. and these values ■were regarded as the controls｡

　　2) 0.05 me/kg of p32 was administered to rabbits with late syphilis and the vanishing

of chicken erythrocytes was observed from ｌ hour to 13 days. From ｌ to 3 hours after

the administration of p32 the vanishing of erythrocytes occurred at l hour 45 minutes

in ｌ case and at ２ hours in ４ cases. which showed ａ relatively low value in comparison

with the controls. From ６ hours to l day after the administration of P32， the time for

vanishing of erythrocytes was l hour 45 minutes in ｌ case. whereas it was ３ hours 30

minutes in ３ cases. 3 hours 15 minutes in ２ cases which presented relatively high figure

within the limit of the controls. After 2 days to 6 days the time tor vanishing of erythro-

cytes was ｌ hour 45 minutes in ｌ case. ３ hours 15 minutes in ２ cases. and in Ｕ cases

　＊　Full-lengthreport: Japanese section pp. 405～411

＊＊　Department of Dermatology (Director: Prof. ０. Miura), Nihon University Hospital, Tokyo

75

tested 17 times the time for vanishing was from ２ hours 15 minutes t0 2 hours 45 minutes.

Furthermore, 7 to 13 days following the administration of 戸2 the time for vanishing was

from ２ hours to 3 hours in all of the cases (Tab. 2)。

　　3) When 0.05 me/kg of Ca*5, whose distribution in the body resembles that of p32

was administered to rabbits, the time for vanishing of chicken erythrocytes of l hour to

13 days following the administration appeared more or less dissimilar to that observed

with P32，but remained within the ｎｍ北of the control values (Tab. 3)｡

　　From the foregoing results, fluctuation of titers of the luetic antibody in rabbits induced

by administering 0.05 me/kg of P32 did not produce an alteration in the function of the reti-

culoendothelial system in cases with late syphilis. Therefore, the use of Tanaka's modi-

ficationof Oh's method of determining chicken erythrocyte phagocytic time as an indicator

to demonstrate the function of the reticuloendothelial system did not provide ａ conclusive

interpretation of the experimental results obtained by Miura。Nakajima, Mizumoto and

Hayashi that P321fluctuates the luetic antibody titerand Ca^s does not have this function.

This functional process may have to be investigated by further study of other factors

involved.

76

A Case of Skin Metastasis (Chorioepithelioma)

　　　of ａ Teratbid Tumor of the Testis*

　　　　　　　　　　　　　　　　　　　　　　　　by

　　　　　　Riichi Kojima, Shigeo Ikeda, Hisashi Nishida and Keiji Mizuoka*゛゛

　　Skin metastasis of teratoid tumor (chorioepithelioma) of the testicle is very rarely-

observed. Statistically there occurred only ３ cases of skin metastasis among ７７５casra of

chorioepithelioma (reported in Japanese gynecological societies. 1945-1954).　While among

１０９cases of teratoid tumor of the testicle, ９ cases had a tissue of chorioepitheliotna in ａ

part of it. 万ａ万ndonly in one case the skin metastasis occurred. The paper presented here

reports ａ case we have recently observ‘ed.

　　Our patient was ａ student 18 years of age. He was　struck on the right testicle in

Judo training about ４ months ago. Thereafter it grew gradually, but there existed ｎｏ･

subjective sufferings.　Since several days before he visited our hospital, however, he had

had pulling pain in the testicle (Fig. 1). Soon after the admission, the right orchidectomy‘

was done (Fig. 2). By histological examination it was revealed to be ａ teratoid tumor and

there was shown ａ tissue of chorioepithelioma in ａ part of it. Just after the surgical

　　　　　　　　　　　1. intradermal form　　　　　　　　2. subcutaneous form

ヅニ匹

Clinical　Findings

Prominently protruding above theskin surface. at times burstingand forming a scab.

Slightly protruding above theskin. surface. though more

protruding when situated onsomething hard.

Ruby red (typicalform). Blue, similarto subcutaneoushematoma.

Histological　Findings

Clumping of tumor cells. Few tumor cellsin hematoma.

Consisting mainly of tumor cellsonly in early metastasis.

　＊

＊＊

Full-length report: Japanese section pp. 412～４３１

Department of Dermatology, (Director: Dr. Ｒ. Kojima) Sanraku-Hospital, Tokyo

77

operation, Nitromin injection and x-ray therapy were begun.　Three months later. there

appeared ａ small ｒedヽtumor under the right breast, and it grew rapidly (Fig. 3)，　ItｗａＳ･

certifiedas metastasis of chorioepithelioma by means of biopsy (Fig. 4,5). Day by day. small

tumors increased in number. Some of them were as large as ａ walnut. blue and slightly

protruded. Others were red like a ruby and more protruded than the blue tumors. His-

tologically the blue one was the subcutaneous form and the red one the intradermal form.

We classifiedthem as the figure in Ｐ. 76.

　　Gynecomastia was observed on both sides (Fig. 6).・　Many shadows. t０３ cm ｉｎ･

diameter, were observed in the χ一犬rayfilm of the chest (Fig. 7) and bloody sputa were

ejected.　Friedman's reaction of the urine was strongly positive. Successive injections of

Nitromin, Azan, Testoluton Forte, produced no effect. The patient died 5 months after

the surgical operation. Autopsy disclosed main metastasis had been hemategenously brought

about. Measurements of sexual hormones at several times are demonstrated on figures

(Figs. 10, 11, 12).　From these findings. we　concluded that the swelling of the breast

was caused not by hyperestrogenism but the imbalance of the ratio between androgen and

estrogen.

78

　　　　　　　Keto-acid Formation by Dermatophytes and Candida albicans*

　　　　　　　　　　　　　　　　　　　　　　　by

　　　　　　　　　　　　　　　　　　　Kenichi Shimbo**

　　The formation十〇ｆ keto-acids by ，dermatophytes and Candida albicans in liquid media

containing glucose and amino adds (glutamic acid or aspartic acid) was studied in this

でpaper.　The keto-acids in the culture fluid were purified as 2,4-dinitrophenylhydrazone

according to the procedure of Haway and Thompson (Biochem. J. 53: 340. 1953).　The

melting point of the hydrazone was the same as that of 2,4-dimtrophenylhydrasone of

authenticα-ketoglutaric acid and pyruvic acid（ｍ･p. 219°C:a-ketoglutaric acid ；ｍ･ｐ，222°C :

pvTuvic acid) and also the samples were identified withα-ketoglutaric acid or pyruvic

acid by means of paper chromatography (Table　1, Fig. 1). Furthermore, the concen-

tration of these keto-acids in the culture fluid was measured by the method of Shimizu

(J. Biochem. 37: 421, 1950) (Table 2，Fig. 2），

　　1）Ｔｈｅ concentration of α-ketoglutaric acid was higher than that of pyruvic acid in

the culture fluid of dermatophytes.

　　2) Pyruvic acid was produced more than α|一犬ketoglutaricacid by Candida albicans in

the culture fluid.

　　3）α-Keto-adds was formed more in the culture fluid containing glutamic acid than

in the ciilture fluid containing aspartic acid by both dermatophytes and Candida albicans.

　　It is considered that these keto-acids may be chiefly formed from glucose following

the pathway of Krebs" cycle.　　　　　　　　　　　　　　　　　‘

　* Full･length report: Japanese section pp. 432―435

＊＊　Department of Dermatology (Director: Prof. Dr. H. Tanaka) Niigata University School

　　　ofMedicine, Niigata

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　79

　　　　　　　　　Transaminase in Dermatophytes and Candida albicans?゛

　　　　　　　　　　　　　　　　　　　　　by

　　　　　　　　　　　　　　　　　　Kenichi Shimbo**

　　The extract of dermatophytes and Candida albicans free from those cells was found

to　catalize　the　transamination reaction in various amino　acids　and　keto-acids.　This

transaminase activity was studied as follows.　Ｔｈｅ十enzyme was prepared by grinding

lyophilized cells, after the alternate freezing and thawing.　Glutamate formed from a-keto-

glutarate was detected by paper chromatography (ascending method) using water-phenol

as the ｓ01▽ent. The density of the ninhydrin spot at the glutamate locus was measured

with the aid of the densitometer. Alanine formed from pyruvate was similarlyｓtｕぷed.

　　1) The transaminase of Trichophyton interdigitale working between a-ketoglutarate

and several amino acids such as aspartic acid, alanine, glycine and phenylalanine was found

to be high in acti▽ity(Table 1，Fig. 1）.　　　　　　　　　　　　　　　　＾

　　2) By the extract of Candida albicans glutamate was formed from α-ketoglutarate

with aspartic acid. alanine, phenylalanine and. toａ lesser degree. with glycine. ormithine.

‘valine, t3ri"osine,･andleucine（Table 1）.

　　3）Ｔｈｅ transaminase of Trichophyton interdigitale working between pyruvate and the

following amino acids such as glutamic acid. glycine, and aspartic acid showed the high

activity (Table l）.

　　4）Ｂｙ the enzyme obtained from Candida albicans alanine was formed from pjmivate

with leucine. aspartic acid. glutamic acid and. to ａ lesser degree, with phenylalanine.

glycine, and valine (Table 1），

　　5) The optimum PH for these transannnases was in the range of 6.2 to 6.6 (Table 2）.

　　6) It was found that salicylic acid, and undecylenic acid have no appreciable effect

cm the transaminase, but on the other hand. merzonine (mercury compound), zinc sulfate,

methylviolet, and iodine showed inhibition of the enzyme (Table 3）.

　　It was thought that the fungistatic effect of merzonine and methylviolet on these fungi

may be partially attributed to the inhibition of the transaminase which is indispensable

for the synthesis of cell protein of these fungi.

　＊　Fulllength report: Japanese scetion･PP- 436～442

＊＊　From the Department of Dermatology (Director: Prof. Dr. Ｈ. Tanaka) Niigata University

　　　School０ｆMedicine, Niigata

80

　　　　　　　　　　　statistical Investigation of Skin Carcinoma*

　　　　　　　　　　　　　　　　　　　　　　　by

　　　　　　　Taro Kawamura, Katsuo Nishiharaでand Hiroo Nakajima**

　　　　　　　Keijiro Tsuchikawa and Nobuo Nakai***

　　　　　　　Ryiiji Mizumoto and Itsuo Miyazaki↑

　　　　　　　Masamichi Nakamura and Shinya Tajiri↑↑

　　　　　　　Minoru Terada and Yoshikazu Kubo#

　　　　　　　Kaoru Taniguchi and Kiyoshi Ｓｈｉｏｏｋａ祚＃

　　The authors made some statisticalinvestigation on skin carcinoma, with the cooper-

ation of the following climes : the Section of Dermatology and the First and Second Sections

of Surgery in Kanazawa University Hospital, and the Sections of Dermatology of Toyama

Prefectural Central Hospital, Toyama Municipal Hospital and Takaoka Agriculture Co-

operative Hospital.

　　1) Clinical records of ｎ２ cases of skin carcinoma, ３１cases of penis carcinoma and

ｎ cases of precancerosis were collected.

　　2) In the six clinics the percentage of skin carcinoma patients among the out一犬patients

varied from 0.02% to 0.12%, and the percentage of penis carcinoma patients from ０.01％

t0 0.04%･

　　3）Ｔｈｅ age bracket which showed the highest percentage was the seventies for skia

carcinoma and the Siχtiesfor penis carcinoma.

　　4) The frequency of skin carcinoma was higher in the male than in the female

（68 : 44).

　　5) As to the origins of skin carcinomas, the commonest was scar. being responsible

for 26.8%. Most of these scars were those resulting from burns (21.4%).　Such a high

rate of burn carcinoma is characteristic　of Hokuriku district,where the 丘ｒｅplace

and firebox (Irori and Kotatsu) are necessary ,for ａ longer time and the chance of people

getting burnt is higher, especially for children.

　*Full-length report: Japanese section pp. 443～449

　**Section of Dermatology (Director: Prof. T. Kawamura), School of Medicine, Kanazawa

　　University, Kanazawa

***First Section of Surgery (Director: Prof. Dr. Ｍ. Urabe), School ０ｆMedicine, Kanazawa

　　University, Kanazawa

　↑Second Section of Surgery (Director: Prof. Dr Ｓ.Kumanomido), School ０ｆMedicine,

　　Kanazawa University, Kanazawa

　↑↑Sectionof Dermatology, Toyama Prefectural Central Hospital (DirectorごDr. Ｉ．Taga"

　　Toyama

　JtSection of Dermatology, Toyama Municipal Hospital(Director:　Dr.Ｂ，Adachi), Toyama

##Sectioii of Dermatology, Takaoka Agriculture Cooperative Hospital (Director: Dr. Ｂ，

　　Toyoda), Takaoka

81.

　　6) Skin carcinomas were predominantly found on the head and the face (53.1%)･

This figure. however, is lower than most other Japanese repwrts.　Only one case ｗａｓ･

found to have arisen from xeroderma pigmentosum （0.9％）.　This seems to be due to the･

general cloudiness in Hokuriku district.ヽ

　　'7) There were more cases of squamous cell carcinomas than those of basal cell

carcinomas among･ skin carcinomas （62: 13), as well as among penis carcinomas･（30: 1）･

　　8) Phimosis seemed to have close connection with the occurrence of penis carcinoma。

being found 25 0f 31 cases（80.6％）･

　　9) Surgical operation　generally brought　about very　good　results　in　both　types　of

carcinoma, but those cases which could not be treated surgically invariably. proved fatal.

Thus it is clear that early diagnosis is most important in skin and penis carcinoma ａＳ。

well as in tumors of other organs.

　　10）Ａｎｄ ６ cases of melanoeplithelioma observed in the Section of Dermatology of;

Kanazawa University Hospital were described.

82

　　　　　　　　　　　　　　　　Ａ Case of Porphyria C!ongenita゛゛

　　　　　　　　　　　　　　　　　　　　　　　by ’

　　　　Kihei Tanioku, Yasuhiko Saida. Sosei Nakayama** and Gunpei Urata***

　　.Ａ girl aged 14，whose parents were consanguineously married had attacks of blisteron

the dorsa of the hands and on the face since the age of２months. The lesionsincreased in

number with years, moreover ulcers and deforming scars developed. Subsequently she had

deformity ･of the nose and fingers. Physical and biochemical examinations were carried

out and following results were obtained.

　　Irradiation by sunlight. ultraviolet rays and sollux ultrared rays gave rise to no reaction

and she had no reaction to mechanical irritation. The liver and spleen were not palpable

and their function was in normal condition. The renal discharge of the 17-ketosteroidswas

high. Blood count showed high degree of anemia. ｅχistenceof normoblasts and augmen-

tation of reticuloerythrocytes. Sternal puncture showed increase of erythrocytic cells and

red fluorescent erythroblasts. In serum iron value decreased with high copper rate and

β-globulin fraction in blood plasma increased with low level 0f albumin fraction. The

urine was free of porphobilinogen as well as δ｡aminolevulinic acid. but uroporphyrin and

small quantities of coproporphyrin were demonstrated by paper-chromatography analysis.

The patient excreted 10-20mg of porphyrin per day.　We presumed that metabolic

disturbance of iron and unbalanced adrenocortical function ｃｏｅχistwith porphyric dysmeta-

bolism in the patient suifering from porphjTia congenita.

　＊　Full-lengthreport: Japanese section pp. 450～460

　＊＊　Department of Dermatology and Urology (Director: Prof. K. Tanioku),

　　　　Facultyof Medicine, Shinshu University, Matsumoto

＊＊＊　Department of Biochemistry, Institute of Public Health, Tokyo

　　Society Transactions

The 42nd Meeting, Tokai Society

　Mie PrefecturalUniversity,Tsu

　　　　　September30, 1956

　　　　ＮｏｒｔhiｓａＮｏｚｏｆｅｉ:　Ａ Case of Papillomatose

　　confluente et reticulee.

　　　　Ａ male, aged 18， had had small papules on

　　the abdominal region since two years, which

　　later spread to the chest, back, lumbal region,

　　neck, axillar　regions, face　and　upper　and

　　lower extremities. They　were closely simu-

　　lated to the clinical picture seen in pityriasis

　　versicolor clinically. The cutaneous lesions. how-

　　ever, showed ａ slight elevation on the normal

　　skin surface. accentuation of the normal skin

　　marking, brownish or reddish-brown in hue and

’no pityriasic scaling.　Histologically, there were

　　moderate hyperkeratosis and papillomatosis in

　　the epidermis. and atrophy of the hair follicles.

　　sweat glands and sebaceous glands could be

　　observed. This was believed to be the similar

　　case reported as second group of　cutaneous

　　papillomatosis by Gougerot　and　Carteaud　in

　　1932.

83

　　HiｒｏｓｈｉＮａｒitａ:　Three Cases of Nenroder-

matitis Linearis｡

　　Three　cases　of neurodermatitis　linearis

were reported here. They were being treated

with the oral administration of antihistaminics

and the local injection of prednisone.

Ｄ幻

cylic

losa

Demonstration of Clinical Sildes

　Pityriasislichenoides chronica

　Drug eruption due to para-amino-sali-

acidr＾　/■~-＼　/--＾

ＣＯ　■＊　iｎ

０乃司㈲

10）

Pityriasis circinata Toyama-Matsuura

Cutis marmorata

Dystrophic form of epidermolysis bul-

Hair folliclenevus

Urticaria pigmentosa

Naevus sebaceus

Ｐｏｉｋ･ilodermiavascularis atrophicans.

Seven　cases　of　leucoderma　due　to

local application of M.B.E.H.

The 43rd Meeting, Tokai Society

　　　NagoyaUniversity,Nagoya

　　　　　　December23, 1955　　　Ｔａｄａｓｈｉ Ｋｏtｏ ａｎｄ ＫａｉｓｕｆｅｅＮｏｇｕcfii: Ａ Case

of Poikilodennia Vascularis Atrophicans｡

　　　Ａ female aged ４７ noticed diffuse reddish

swelling and edema On the face and extremities

on May 1955. Since spring in 1956, she has had

dryness and atrophy of the skin of the face and

exposed area, subsequently weakness and fatiga-

bility developed. The cutaneous lesions showed

atrophy, telangiectasis and　hyperpigmentation

mixed with 8potted depigmentations. Marked

atrophy of muscles in the back and the shoulder

was noted. Differential diagnosis between der-

matomyositis and poikilodermia vascularis atro-

phicans was discussed｡

　　　ＫｅｆtｓＭｒｏ Ｓａｓａｄａ ａｎｄ Ｈtｒｏｂｕtｎｉ　７Ｗｏ？･れ　Ａ

Case of Peutz-Jeffhers゛ Syndrome｡

　　　Ａ female aged ２２ has ‘tad numerous small

pigmented spots on her lips. oral mucous mem-

brane, soles and palms since long years. Multiple

polyps in the intestinal tractus were revealed

.by χ Γay examination. The details will be

　published elsewhere.

　　　　Ｔｏｄｏｓｈｉ Ｋａtｏ ａｎｄ Ｔａｆｅｅｏ Ｏｎｏ:　Treatment

　of Aloepcia with Cepharanthin.

　　　　Fourteen cases of alopecia areata including

　alopecia maligna and three cases of juvenile

　alopecia were treated with oral, parenteral and

　topical　administration　of cepharanthin. The

　results obtained were as follows:　Excellent in

　3, effective in 6, slightly effective in 3， no benefit

　in ５ cases.

　　　　Yusみｏ　ＯＩα。Zennos認知　Kosugi, Masakiko

　Ｎｏｇｕｒａ ａｎｄ Ｊｉｒｏ Ｙｏｆｅｏtafee:　Ａ Fatal Case of

　Purpura.

　　　　A girl aged 13 was admitted to the hospital

　on last August, because she 蛍ａＳ complaining

　of epistaxis.　After the admission, she died

　from brain-hemorrhage. The detail　autopsy

　records were reported.

　　　　Ｙａｉｕｈｉｋｏ　Ｓａｉｄａ, 　Ｙｏｓｕａｆｅｉ　Ｔｏｆｅｕｄａ， 　Ｙｏｓliｔｙａ

　Yamada and召lioski Murata:1）　Ａ Case of

Nylon　Dermatitis. 2) A Case of Montr's

S4

Disease｡

　　1）A 58-year-old man, had developed der-

matitis due to nylon socks on both feet. The

:following 8 kinds of patch tests were carried

･out, and the positive reactions were recognized

ﾆin the (3), (4) and (5) tests. (1) penicillin G-

vaseline (10,000u/g), (2) 2% procaine･vaseline.

expected｡

　　　Ｈｉｄｅｏ Ｋｏｆｅｅｉ ａｎｄ Masahikりj面剋ﾀIQ:　Two

Cases of Acanthosis Nigrricans｡

　　　1）Ａ patient of gastric cancer. has de-

"veloped typical eruptions≪of acanthosis nigricans

　in the axillae since ３ months after the gastro-

tomy was performed. The histologic picture was

also typical｡

　　　2）Ａ man, 65 years of age, has developed

verrucae on the dorsa of the hands and feet,

■erosionand rhagades on the lips. dark brown

pigmentation on the face, in the axillae and

inguinal regions, and　ａ　tumor (presumably

gastric cancer) in the･abdomen.

Ａ specimen

taken from the axilla showed the typical his-

tologic picture of acanthosis nigricans｡

　　　Discussioｎ;　Ｎｏｂｏｒｕ　Ｙａｎｏ:　Ａ woman over

50, had had minute senile verrucae and brow-

nish pigmentation almost over the whole body.

and eruptions simulating acan thosis nigricans on

the patellae, but not in the axillae. Therefore,

the diagnosis was very difficult. Later, however.

she died of gastric cancer｡

　　　Ｔｏｓｈｉｏ Ｋｏｂａｙｓｏｓｋｉ ａｉｌｄ Ｙｕtａｋａ Ｎｏｒitｏ　･.　The

Use of Biotin in the Treatment of Various

Sermatoses｡

　　　Forty　cases　of　inflammatory　dermatoses

were treated with Biotin, and the clinical data

-were presented｡

　　　Eiｓｕfee Mitｓｕタａ, 　Ｙａｓt