Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United...

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Organ Printing Vi Tran BME 181 April 1, 2013

Transcript of Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United...

Page 1: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

Organ PrintingVi Tran BME 181 April 1, 2013

Page 2: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

The Need For Organs Today

-117,521 people in United States in need of organ according to organdonor.gov-Each day 79 receive organ each day while 18 will die from a lack of one-Kidneys, hearts, livers, lungs are most needed organs

Page 3: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

What is Organ Printing?-Integrating biology and 3-D printing technology-A process where an artificial organ can be created using a 3-D printer/bioprinter-Currently NO real organ has been successful created, but scientists are currently working on this idea and are making progress

-First commercial bioprinter company is Organovo-Printed blood vessels and cardiac tissue from chicken cells in 2008

Page 4: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

How Does It Work?-Uses bioink, mixture of stem cells-Printer moves back and forth dropping out one bioink particle at a time to form one layer-Printer prints out one layer of cells at a time on biopaper, which is made up of collagen, water, and hydrogels-Layers are printed one top of each other-After cells fuse, biopaper is removed

Page 5: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

Current Developments: Doctor Anthony Atala

-Director at Wake Forest Institute of Regenerative Medicine and a surgeon-Part of the team that created first functional artificial bladder to be implanted in a human-In 2011, successfully printed a kidney from human cells in seven hours-Not functional in humans yet but his research is still in progress

Page 6: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

Current Developments: University of Pennsylvania

-Team: Dr. Jordan Miller, Dr. Christopher Chen, and Dr. Sangeeta Bhatia-Created a sugar template that can helps shape development of a vascular network for artificial organs-After network is printed, cells are inserted and network then grows-Sugar template is dissolved after completion of development

Page 7: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

Why Doesn’t it Work?-Difficult to create blood vessels between tissue layers-Organs have many specialized functions difficult to replicate

Page 8: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

Benefits and Disadvantages-Artificial organ personalized using patients own cells-No DNA rejection-Eliminate need for immunosuppressant drugs needed after a regular organ transplant -Eliminate organ donation-No waiting period

-Printers cost hundreds of thousands of dollars-Possibly more expensive than regular organ transplant-Use of stem cells is still controversial-Cost of using stem cells-Not successfully created yet

Page 9: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

The Future-Advancements in tissue engineering and 3-D printing technology will help in development of artificial organs from organ printing-If achieved, more lives could saved and prolonged

Page 10: Organ Printing Vi Tran BME 181 April 1, 2013. The Need For Organs Today -117,521 people in United States in need of organ according to organdonor.gov.

Questions?Works Cited

"3-D Printing Getting Organ-ized." Urban times, 2013. Web. 30 Mar. 2013. <http://urbantimes.co/2011/12/3d-printing-getting-organ-ized/>."Bioprinting." N.p., 1 Mar. 2013. Web. 30 Mar. 2013. <http://www.explainingthefuture.com/bioprinting.html>.Hill, David. "GROWING HUMAN ORGANS — DR. ANTHONY ATALA BLOWS THE MINDS OF A TED AUDIENCE." N.p., 2012. Web. 30 Mar. 2013. <http://singularityhub.com/2011/03/15/growing-human-organs-%E2%80%94-dr-anthony-atala-blows-the-minds-of-a-ted-audience/>.Lerner, Evan. "Penn Researchers Improve Living Tissues With 3D Printed Vascular Networks Made From Sugar." University of Pennsylvania, 1 July 2012. Web. 30 Mar. 2013. <http://www.upenn.edu/pennnews/news/penn-researchers-improve-living-tissues-3d-printed-vascular-networks-made-sugar>."Media Coverage." Organovo, 2013. Web. 30 Mar. 2013. <http://investors.organovo.com/Newsroom/Media-Coverage/default.aspx>."Organ Printing: Computer-aided Jet-based 3D Tissue Engineering." N.p., n.d. Web. 30 Mar. 2013. <http://www.ncbi.nlm.nih.gov/pubmed/12679063>.U.S. Government Information on Organ and Tissue Donation and Transplantation, n.d. Web. 30 Mar. 2013. <http://www.organdonor.gov/index.html>.


The facts about critical illnesses - Memphis€¦ · 3 U.S. Department of Health and Human Services, “The Need is Real: Data,” organdonor.gov (accessed 2016). 4 Centers for Disease

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