(A) Emisphere: Eligen� Technology : Eligen Technology

OH

OH

N

O

O

O-Na+

H

OH O

( S C) Protein Drug Delivery Agent (i.e., SNAC)Lipophilic

Protein/Delivery

Blood Biological

Membrane

Protein/Delivery

Agent Complex

(B) Altus: Cross-Linked Enzyme Crystal (CLEC�) Technology

High Stability & Purity

High ConcentrationHigh Concentration

Superior Delivery

Options (Oral & Injectable)

S l bl P t i

p ( j )

P t i C t lSoluble Protein Protein Crystals

(C) BioSante: BioOral System (Calcium Phosphate Nanoparticles)

CAP-PEG-Insulin ParticlesCAP PEG Insulin Particles

(Hydrophobic Core)

Hydrophilic layer (mostly �-caseins)(mostly � caseins)

(D) Generex: Oral-Lyn�

(a) (b)

(E) NOBEX and Biocon: Amphiphilic Oligomers

om

er

�Chain

co

lig

oh

iph

ilic

�Ch i

Am

ph

�Chain