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DEPARTMENT OF PHARMACEUTICSSHRI B. M. SHAH COLLEGE OF PHARMACEUTICAL EDUCATION AND REASERCH,

MODASA-2013

CONTENTS

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IntroductionClassificationAdvantages and DisadvantagesRaw Material SpecificationsDepartmental Layout of Liquid ManufactureQuantitative Layout Of Liquid PreparationImportant QuestionsReferences

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INTRODUCTIONINTRODUCTION

Liquid dosage form are one class of dosage form, which are meant for either internal, external or parenteral use.

Liquid dosage forms are prepared by dissolving active ingredients in an aqueous or non-aqueous solvent, by suspending the drug or by incorporating the drug into one of the two phases of an oil and water systems.

LIQUIDS

MONOPHASIC BIPHASIC

ORAL USE

EXTERNAL USE

PARENTERAL SPECIAL USE

Used in Oral cavity

Used in other than oral cavity

LIQUID IN LIQUID

SOLIDS IN LIQUID

Oral useEMULSION

External useLINIMENTS

Parenteral OralSUSPENSION

ExternalLOTION

SOLUTIONDRAUGHTSDROPSLINCTUSESSYRUPSELIXIRS

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CLASSIFICATIONCLASSIFICATION

1. Immediately available for absorption2. Easy administration 3. They are most suitable dosage forms for infants, children, geriatric and mentally disturbed patients.4. Bitter and obnoxious drugs can be easily given in sweetened, colored and flavored vehicles.5. Doses can easily be varied as per the requirement of the patients.

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ADVANTAGESADVANTAGES

DISADVANTAGESDISADVANTAGES1 . Less stable compare to solid dosage forms.2. Liquid dosage forms are bulky and therefore inconvenient to carry, transport and store.3. Incompatibility is more in liquid dosage forms as compare to solid dosage forms.4. Patients have no accurate measuring device.5. In case of accidental breakage of the container, it may result in loss of the whole dosage forms.

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Raw Material Specifications 

Raw Material Specifications 

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DEPARTMENTAL LAYOUT OF LIQUID MANUFACTURING

DEPARTMENTAL LAYOUT OF LIQUID MANUFACTURING

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•An area requirement for installation of equipment minimum 30 m2.

Q C

Offices Gowning

Canteen

Incoming goods

Corridor

Corridor

Shipping

Corridor

Packaging

Weighing Processing

Filling

Raw Materials

& Packaging

Storage

Washing

Machine Shop

Finished Products Storage

Corridor Utilities and Services Waste Treatment

Arrival of Entrance for Entrance for Shipment of goods visitors Workers goods

Material flow People flow

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Making Liquid Syrup

Suppose, Plant Capacity:- 1,00,000boottles/day

For preparing:- 1,00,000 bottles (each containing 50ml of liquid syrup)

So, total syrup making:- 5000 L

Raw material Quantity:-

•Drugs:- 10 Kg

•Std granulated sugar:- 2750 Kg

•Other excipients:- 1000 Kg

•Purified water:- q.s

QUANTITATIVE LAYOUT OF LIQUID PREPARATIONQUANTITATIVE LAYOUT OF LIQUID PREPARATION

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OFFICE

C

O

R

R

I

D

O

R

RAW MATERIALAPI & EXCIPIENT

10sq.M

LIQUID & SOLVENT

MEDICINE PREPERATION AREA

30sq.M

SEMI FINISHED STORE

I.P.Q.C.

OFFICE

WASHING EQUIPMENTSTORAGE AREA

WASHING AREA

10sq.MEMPTYBOTTLESTORAGEAREA

LABELING 20sq.M

PACKAGING 20sq.M

FINISHED PRODUCTSTORAGE AREA

30sq.M CHANGE ROOM

GOWNING ROOM

DISTILLATION UNITEXCISE DUTY

syrup

WASHING 10sq.M

FILLING & SEALING 10sq.M

Temp:-25˚CIf hygroscopicTemp:-<25˚CIf sterile areaTemp:-18˚C

Humidity:-40%If hygroscopicHumidity> 40%

Q.C

IMPORTANT QUESTIONS(GTU EXAMS)

IMPORTANT QUESTIONS(GTU EXAMS)

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1. Explain departmental layout with specific requirement of equipments for oral liquid dosage forms. 05

1. Explain departmental layout with specific requirement of equipments for oral liquid dosage forms. 05

2. How will you prepare qualitative and quantitative departmental layout with equipments required for liquid dosage forms? 05

2. How will you prepare qualitative and quantitative departmental layout with equipments required for liquid dosage forms? 05

3. Explain qualitative and quantitative deparmental layout for liquid orals. 05 NOTE:-2 TIMES IN BOARD

3. Explain qualitative and quantitative deparmental layout for liquid orals. 05 NOTE:-2 TIMES IN BOARD

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REFERENCEREFERENCE

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Thank you very much

Success is not a

destination ,

it’s a journey.

A will find a way.

Ph. No. :- +91-8460378336

Address:- 44, Assiyana Society;

Dugarvada Road,

Taluko & City : Modasa

State: Gujarat

Country: India

Email: sahil.pharm4@gmail.com

BEST OF LUCK TO ALL . . . . . . . . . . . . . .

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