Daymar College Lisa H. Young, RN, BSN, MA Ed. Classifications and Prototype Drugs (Pr) Pregnancy…
Oral Hypoglycemic Drugs And Classifications
Click here to load reader
description
Transcript of Oral Hypoglycemic Drugs And Classifications
![Page 1: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/1.jpg)
Oral Hypoglycemic Drugs And Classifications
Heider SH. QassamMSc.PH. & TH.
![Page 2: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/2.jpg)
To understand Oral Hypoglycemic Drugs And Classifications
Goal
![Page 3: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/3.jpg)
Oral Hypoglycemic Drugs: These agents are useful in the treatment of patients who have Type 2 diabetes but who cannot be managed by diet alone.
![Page 4: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/4.jpg)
Oral Hypoglycemic Classification
Insulin Secretagogues
I.Sulfonylureas
II.Meglitinide analogs
Insulin Sensitizer
s
III.Biguanides
IV. Thiazolidinediones
V.α-Glucosidase Inhibitors
![Page 5: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/5.jpg)
![Page 6: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/6.jpg)
(mechanism of action) :A. Increase release of insulinB. Decrease production of glucose in the liverC. Increase the number of insulin receptorsD. Effective only if have functioning beta cells Side effect is hypoglycemia and weight gain These drugs include glibenclamide, glipizide,
and glimepiride .
I.Sulfonylureas
![Page 7: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/7.jpg)
Nateglinide and repaglinide are nonsulfonylureas that lower blood sugar by stimulating pancreatic secretion of insulin
In contrast to the sulfonylureas, the meglitinides have a rapid onset and a short duration of action
They are categorized as postprandial glucose regulators
Monotherapy or in combination with metformin Should be taken 1 to 30 minutes before a meal Side effects hypoglycemia and weight gain
II.Meglitinides
![Page 8: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/8.jpg)
(mechanism of action): increases the use of glucose by muscle and fat cells, decreases hepatic glucose production, and decreases intestinal absorption of glucose
Does not cause hypoglycemia May be used alone or in combination Side effects include GIT disturbance and
lactic acidosis Contraindicated in liver or renal impairment.
Can result in lactic acidosis. This group include metformin
III.Biguanides
![Page 9: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/9.jpg)
(mechanism of action):Decrease insulin resistance. Through binding with PPAR lead to regulation adipocyte production and secretion of fatty acids as well as glucose metabolism, resulting in increased insulin sensitivity in adipose tissue, liver, and skeletal muscle
Side effects include weight gain, headache and anemia
Contraindicated in patients with liver disease and acute MI
May be used as monotherapy or in combination with insulin, metformin or a sulfonylurea
These drugs include Pioglitazone and rosiglitazone
IV. Thiazolidinediones
![Page 10: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/10.jpg)
Include acarbose and miglitol (mechanism of action): inhibit alpha-
glucosidase enzymes in GI tract. Delays absorption of complex CHO and simple sugars
Can be combined therapy with sulfonylurea
Contraindicated in malabsorption, severe renal impairment
Side effects include bloating and diarrhea
Alpha glucosidase Inhibitors
![Page 11: Oral Hypoglycemic Drugs And Classifications](https://reader038.fdocuments.in/reader038/viewer/2022102422/568142db550346895daf3409/html5/thumbnails/11.jpg)
Thank you