OncomicsOncomics ex vivo primary cancer growing model. A lot of different cell types. Due to cancer...
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Transcript of OncomicsOncomics ex vivo primary cancer growing model. A lot of different cell types. Due to cancer...
Oncomics.deanticancer drug development
and theranostic service
Main anticancer drug developmental problem is: pharma R&D have NO model for specific pharmacological activity – we can try medication efficiency on patients only
• In vitro cell cultures (even 3D, primary, long-term, ets.) - not representative
• Murine cancer models (both mice and rats)– not representative
In vitro 3D cultures Ex vivo In vivo mousecancer model
Oncomics ex vivo primary cancer growing model. A lot of different cell types.
Due to cancerplasticity:differentcell types with functional heterogeneity among cancer cells in some tumors
Why?
At the present time reliable results of the anticancer drugs effects can be only if we grow human cancer in mice
Human cancer in miceHuman
cancer
Project mission is: the providing of powerful high-tech tools set service for anticancer drug discovery:
•Targeted Cancer Therapies•Radiotracers for Oncology •Clinical Oncology and Science
1. Cancer tissue isolation- Cancer tissues:
- surgery- open biopsy- laparoscopic
biopsy- surface biopsy
- Body liquids- Blood
2. Liquid biopsy growing- Fast biopsy blast
growing method*:- 3 day- 1 week
- Low speed biopsy growing method*:
- up to 1 year
*know how
3. Engraftment tumor in PDX- Mice tumor
engraftment :- P0-P12 PDX- Orthotopic and
heterotopic surgery transplantation
4. Cancer growing visualization
Mice magnetic resonance imaging (MRI)
Mice computed tomography imaging (CT)
5. Treatment examination
2.Chemotherapy or/and radiotherapy
1.Mice cancer engrafting
4.Analysis(DNA damage imaging)
1.1.And liquid biopsycultivation
3.Surgery isolation
6. Blast clones growingCancer tissue clones «fast growing»
- ex vivo clones
PD-1 PDL-1 CTLA4
7. Surgery facility
Cancer tissue surgery and isolation
8. Metastatic PDX model
Metastatic cancer PDX models
General technics:- Cancer tissue isolation: all types of cancer
can be used* and any surgery technics can be performed;
- Fast or slow primary cancer liquid biopsy growing;
- Engraftment the cancer in mice (PDX);
- Treatment, surgery and treated cancer tissue examination
* All types of cancer which can be grown – cancer must be able to grow in models.
Key features:- Whole research cycle – «only medication
from the pharma company-client»;
- Treatment mice with human protocols and with the same instruments;
- Lead scientific and oncologists administration;
- Human experimental treatment (in accordance with the official protocols);
Key techniques:- Primary cancer tissues are used
(maximally representative of the patient tumor clone structures)
- Cancer therapy combination can be performed (e.g. combination of chemotherapy, radiotherapy and target therapy)
Animal protection note:- Our research protocols
exclude the premeditated killing of animals
Thank you for attention!
