Oncology Drug List

7/28/2019 Oncology Drug List

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Oncology Drug List(1-2-13)

Youareresponsibleforthemechanismsandsideeffectsofsingledrugs.Theboldedonesarethemostimportantexemplarsofeachclass.

Drug class Sub-class Generic name Brand name

1

Toxicities / Special considerations

Antineoplastic Alkylating agents Bendamustine RIBOMUSTIN; TREANDACommon alkylator; causes intra-strand and inter-strand cross-links between DNA bases.

Busulfan BUSULFEX, MYLERAN

Common alkylator :myelosuppression includingthrombocytopenia, anemia, granulocytopenia,alopecia, gonadal dysfunction, mucositis (= irritation ofgut lining), second neoplasms, and pulmonaryfibrosis.

Carboplatin PARAPLATIN Toxicity:heme>>>>renal/neuro ; dose by AUCCarmustine BCNU Common alkylator; cross blood brain barrier

Chlorambucil LEUKERAN Common alkylator; oral bioavailability

Cisplatin PLATINOL Toxicity:renal>neuro / oto>hemeAttenuate renal toxicity by hydration

Cyclophosphamide CYTOXAN

Common alkylator; Prodrug: active alkylator producedas a result of hepatic metabolism; metabolitesbladder toxic therefore high doses use MESNA forbladder protection; High doses: cardiac toxicity

Used in curative regimens for non-Hodgkinslymphoma

CHOP: Cyclophosphamide + doxorubicin + vincristine+ prednisone

CVP: Cyclophosphamide + vincristine + prednisone

Dacarbazine DTIC Common alkylator; very emetogenic

Ifosfamide IFEX, MITOXANA

Similar to cyclophosphamide in mechanism but morefavorable activity in certain disease types e.g.sarcoma. REQUIRE bladder protection with MESNAat all doses. Encephalopathic especially with renalcompromise. Fanconi syndrome, azotemia alsocommon

Lomustine (CCNU)Common alkylator; oral bioavailable; cross blood brainbarrier

1The particular brand name does not suggest or recommend use of any drug; it is only provided to give an appreciation of common brand names

Common alkylator toxicities: myelosuppression including thrombocytopenia, anemia, granulocytopenia, alopecia, gonadal dysfunction, mucositis (= irritation of gut

lining), second neoplasms, and pulmonary fibrosis.


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Melphalan ALKERAN Common alkylator; oral bioavailable

Mechlorethamine MUSTARGENParent drug of the class; common alkylator toxicity;vesicant; emetogenic

Oxaliplatin ELOXATIN Toxicity: neuro>>heme>>>>>renal

Procarbazine MUTALANECommon alkylator; neurotoxic with altered mood,somnolence

Temozolomide TEMODARCommon alkylator; oral bioavailability; cross blood

brain barrier

Antibiotics Bleomycin BLEOCIN, BLENOXANE

Renal clearance therefore reduce dose in renalcompromise; dose related pulmonary toxicity; laterecall on exposure to high PO2 or with radiation;Raynauds hypersensitivity therefore precede withtest dose

Curative regimens ABVD (Adriamycin + bleomycin +vinblastine + dacarbazine) for Hodgkins and PEB

(Cisplatin + etoposide + bleomycin) for germ cellneoplasms

Dactinomycin COSMEGENMyelosuppression; Nausea / vomiting; Mucositis;Diarrhea; Vesicant-avoid extravasation; Radiationrecall Curative pediatric neoplasm regimens

Topo II Inhibitors DaunorubucinDAUNOMYCIN,CERUBIDINE,

RUBIDOMYCIN

Common anthracycline toxicities: myelosuppression;vesicant; mucositis; gastrointestinal (nausea;diarrhea) dose related cardiac toxicity; interaction withradiation therapy

Doxorubicin orhydroxy-daunorubicin

ADRIAMYCIN; DOXILCommon anthracycline but more mucositis on a doseper dose basis than dauno

Epirubicin ELLENCE Common anthracyclinetoxicities

Etoposide EPTOPHOS Myelosuppression, alopecia

Mitoxantrone NOVANTRONERelated to anthracyclines but somewhat lesscardiotoxic; also myelosuppression, mucositis,gastrointestinal

IdarubicinCommon anthracycline but less cardiotoxic on aweight basis


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Antibodies(mAbs)

Alemtuzumab CAMPATHAnti CD52; use in CLL, T cell leukemias; infusionreaction (chills, fever, shortness of breath +/-hypotension) tumor lysis syndrome

Bevacuzimab AVASTATIN, AVASTINAnti Vascular Endothelial Growth Factor; bleeding,clotting, hypertension, proteinuria, seizures / altered

mental status, perforated viscusCetuximab ERBITUX Anti EGF receptor; diarrhea, rash

Rituximab RITUXANAnti CD20; use in B cell lymphomas; Infusion reaction(chills fever, shortness of breath +/- hypotension)

Trastuzumab HERCEPTINAnti-erbB2; Infusion reaction (chills, fever, shortnessof breath +/- hypotension); cardiac toxicity

Ipilimumab YERVOY

Anti-CTLA4; stimulate immunity; infusion reactions(chills, fever, shortness of breath +/- hypotension);exaggerated autoimmunity esp hepatic and gutdysfunction

Antimetabolites Decitabine, Azacitidine DACOGEN, VIDAZANucleosides: Myelosuppression and hypomethylateDNA at low doses

Cytarabine(cytosinearabinoside)

ARABINOSIDE C, ARA-CNucleoside: Myelosuppression, nausea, rash,mucositis, ocular irritation and cerebellar toxicity otherCNS at high doses

Fludarabine FLUDARANucleoside: Myelosuppression, CNS and neuro;immunosuppression and rare hemolytic anemia

Fluorouracil ADRUCILPyrimidine analog: Myelosuppression, mucositis, CNS

at high doses

Gemcitabine GEMZAR Nucleoside: Myelosuppression; hand-foot syndrome

Mercaptopurine PURINETHOLPurine analog: Myelosuppression, nausea,uncommon hepatic

Methotrexate TREXALL

Antifolate: Mucositis, myelosuppression; renalclearance therefore enhanced toxicity at increased Cr;renotoxic by direct effect on tubules and byprecipitation at high doses; inhibit dihydrofolatereductase therefore rescue with reduced folatesespecially leucovorin

Pentostatin NIPENTAdenosine deaminase inhibitor therefore increase

dATP pools and inhibit production of other dNTPs and


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induce apoptosis in T lymphocyte lineage; renal, CNStoxicity

Pemetrexed ALIMTAAntifolate but also target additional enzymes of purineand pyrimidine synthesis; give with low doses of B12and folate

Anti-microtubular Docetaxel TAXOTEREMyelosuppression; neuropathy; vascularleaksyndrome = fluidretention

Ixabepilone IXEMPRA Myelosuppression, neuropathy

PaclitaxelTAXOL, ONXEL(ABRAXANE

2)

Myelosuppression, neuropathy; vascularleaksyndrome = fluidretention

Vinblastine (in ABVD) VELBAN Myelosuppression, neuropathy

Vincristine ONCOVIN Neuropathy>myelotoxicity

Vinorelbine NAVELBINE Myelosuppression; neuropathy

Growth/CSfactors

Erythropoietin (epoetin) EPOGEN, PROCRITClotting if to Hgb> 10?promote tumor growth

Filgrastim (r-metHuG-CSF) NEUPOGENFever, chills, bone pain ; exacerbation of inflammatorystates

G-CSF or GM-CSF (see filgrastim; sargramostim)

Sargramostim (rHuGM-CSF)

LEUKINESomewhat higher incidence of fever

HDAC Inhibitor Romidepsin ISTODAX Cardiac; myelosuppressionVorinostat ZOLINZA Nausea; myelosuppression; clotting

2Suspension of protein-bound drug,


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Hormonaloncologics

Anastrazole ARIMIDEXAromatase inhibitor: Bone loss; fatigue

Bicalutamide CASODEX Androgen receptor antagonist; Bone loss

Diethylstilbestrol (DES) Estrogen receptor antagonist: Bone loss; thromboses

Exemestane AROMASIN Aromatase inhibitor: Bone loss; fatigue

Flutamide EULEXIN Androgen receptor antagonist: nausea

Fulvestrant FASLODEX Indirect estrogen receptor antagonist; Bone loss

Goserelin ZOLADEX (LHRH analog)Hypothalamic stimulator of continuous LH releasetherefore lose normal pulsatile release and effectivelydecrease net LH release

Letrozole FEMARA (LHRH analog)Aromatase antagonist: bone loss, musculoskeletalfatigue

Leuprolide LUPRON LikeGoserelin

Megestrol MEGACEProgesterone-related side effects : fluid retention,constipation

Methyltestosterone ANDROID

Nilutamide NILANDRON

Prednisone (in CHOP and CVP)Glucocorticoid excess: hyperglycemia, fluid retentiongastric irritation Cushings syndrome, increasedopportunistic infections; myopathy; CNS changes

Tamoxifen NOLVADEXBone loss, thrombogenic with deep venous and largeorgan thromboses; uterine neoplasms as partialagonist in uterus

Topoisomerase-Iinhibitors

Irinotecan CAMPTOSARMyelosuppression, nausea, diarrhea (acute diarrheatreat with anti-cholinergic; late diarrhea withloperamide); Dose according to UGT allele status

Topotecan HYCAMTIN Myelosuppression, nausea

Tyrosine kinaseinhibitors (TyrK-I)

Crizotinib XALKORIAnti-ALK (anaplastic lymphoma kinase)/c-MET/HGFR;nausea, vomiting, or diarrhea

Dasatinib SPRYCELTargets include BCR/ABL, Srd, c-Kit, ephrinreceptors, other TKs, but not EGFR or Her2

Erlotinib TARCEVA Anti EGF-R ; diarrhea, rashGefitinib IRESSA Anti EGF-R : diarrhea, rash

Imatinib GLEEVEC Anti bcr-abl: fluid retention, hepatic,


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myelosuppression; rare cardiac

Nilotinib TASIGNAInhibits the kinases (BCR-ABL, KIT, LCK, EPHA3,EPHA8, DDR1, DDR2, PDGFRB, MAPK11 and ZAK

Sorafenib NEXAVARMulti-target with prominent Anti raf, VEGF-R: rash,diarrhea, hypertension, rare hepatic; clotting /bleeding proteinuria ALSO: hand-foot syndrome

Sunitinib SUTENTMulti-target with prominent Anti VEGF-R: rash,diarrhea, hypertension, rare hepatic; clotting /

bleeding proteinuriaBoustinib BOSULIF Recurrent CML

Ponatinib CML with T315I mutation

Vemurafenib ZELBORAF B-RAF mutated melanoma

Other oncologics Bortezomibproteasome inhibitor -VELCADE

Thrombocytopenia, neuropathy

Hydroxyurea HYDREA Myelosuppression, mucositis

Lenalidomide REVLIMIDImmune modulator for myeloma, myelodysplasiaCytopenias, thrombosis, edema

Thalidomide THALOMIDImmune modulator for myeloma,Cytopenias, thrombosis, edema

Antidote to folicacid antagonists

Leucovorin ISOVORIN ; SODIOFOLINPotentiate 5FU toxicity ; ImproveMethotrexatetoxiciy

Anti-emetictherapy

Aprepitant EMEND

Dexamethasone(steroid) DECADRONCushings syndrome; can also be used as anoncologic therapeutic

Dolasetron ANZEMET

Granisetron KYTRIL

Ondansetron ZOFRANPalonosetron (LA) ALOXI

Additionalhematologic

Arsenic TrioxideUnique use in acute promyelocytic leukemia:Prolonged QT syndrome, hepatic, renal

IL-2 PROLEUKINFever, infusion reactions with hypotension andvascular leak syndrome

-Interferon INTRON-A FeverTretinoin (all-trans- VESANOID, RETIN-A, Unique use in acute promyelocytic leukemia;


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retinoic acid) Increased intracranial pressure; cutaneous; rarehepatic

* UMM Medical Reference: http://www.umm.edu/medref/

Youareresponsibleforthemechanismsandsideeffectsofsingledrugs.Theboldedonesinthesecondlistarethemostimportantexemplarsofeachclass.
http://www.umm.edu/medref/http://www.umm.edu/medref/


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ALPHABETICAL LIST

interferon INTRON-A Additional hematologic

Alemtuzumab CAMPATH Antibiotics

Anagrelide AGRYLIN Additional hematologic

Anastrazole ARIMIDEX Hormonal OncologicsAprepitant EMEND Anti-emetic therapy

ARA-C (see Cytarabine)

Azacitidine VIDAZA Antimetabolites

Bendamustine RIBOMUSTIN; TREANDA Alkylating agents

Bevacuzimab AVASTATIN, AVASTIN Antibodies (mAbs) (VEGF)

BCNU (see carmustine)

Bicalutamide CASODEX Hormonal Oncologics

Bleomycin (and in ABVD) BLEOCIN; BLENOXANE Antibiotics-oncologicsBortezomib VELCADE Proteasome inhibitor

Busulfan MYLERAN Alkylating agents

Carboplatin PARAPLATIN Alkylating agents

Carmustine BCNU Alkylating agents

Cetuximab ERBITUX Antibodies (mAbs)

Chlorambucil LEUKERAN Alkylating agents

CHOPCyclophosphamide, hydroxy(doxo)rubicin,

ONCOVIN (vincristine), prednisoneCisplatin PLATINOL Alkylating agents

Cis-retinoic acid ACCUTANE Additional hematologic

Cirzotinib XALKORI Anti-ALK (anaplastic lymphoma kinase

CVP Cyclophosphamide, vincristine, prednisone

Cyclophosphamide CYTOXAN Alkylating agents

Cytarabine(cytosine arabinoside) ARABINOSIDE C, ARA-C Antimetabolites

Dacarbazine DTIC Alkylating agents


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Dactinomycin COSMEGEN Antibiotics-oncologics

Dasatinib SPRYCELTyrosine kinase inhibitor, but NOT EGFR orHer2

Daunorubucin CERUBIDINE; DAUNOMYCIN; RUBIDOMYCIN Antibiotics-oncologics, Topo II Inhibitors

Decitabine DACOGEN Antimetabolites

Dexamethasone (steroid) DECADRON Anti-emetic therapy

Diethylstilbestrol (DES) HormonalDocetaxel TAXOTERE Antitubulin

Dolasetron ANZEMET Anti-emetic therapy

Doxorubicin (hydroxydaunorubicin) ADRIAMYCIN; DOXIL Antibiotics-oncologics, Topo II Inhibitors

Epirubicin ELLENCE Antibiotics-oncologics

Erlotinib TARCEVA Tyrosine kinase inhibitors(EGFR)

Erythropoietin (epoetin) EPOGEN; PROCRIT Growth factors

Estramustine EMCYT Hormonal Oncologics

Exemestane AROMASIN Hormonal Oncologics

Filgrastim (r-metHuG-CSF) NEUPOGEN Growth factor

Fludarabine FLUDARA Antimetabolites

Fluorouracil ADRUCIL Antimetabolites

Flutamide EULEXIN Hormonal Oncologics

Folinic acid (see leucovorin)

Fulvestrant FASLODEX Hormonal Oncologics

GCSF LEUKINE (see Sargramostim) Growth factorsGefitinib IRESSA Tyrosine kinase inhibitors(EGFR)

Gemcitabine GEMZAR Antimetabolites

Goserelin ZOLADEX Hormonal Oncologics (LHRH analog)

Granisetron KYTRIL Anti-emetic therapy

Hydroxyurea HYDREA Other oncologics

Ifosfamide IFEX; MITOXANA Alkylating agents


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IL-2 PROLEUKIN Additional hematologic

Imatinib GLEEVECTyrosine kinase inhibitors, BCR-

ABLhematologic

Ixabepilone IXEMPRA Antimicrotubular

Irinotecan CAMPTOSAR Topoisomerase I inhibitors

Letrozole FEMARA Hormonal Oncologics

Leucovorin ISOVORIN ; SODIOFOLINAntidote to folic acid antagonists;

Potentiator of 5FU toxicityLeuprolide LUPRON Hormonal Oncologics (LHRH analog)

Lomustine (CCNU) Alkylating agents

Mechlorethamine MUSTARGEN Alkylating agents

Megestrol MEGACE Hormonal Oncologics

Melphalan ALKERAN Alkylating agents

Mercaptopurine PURINETHOL Antimetabolites

Methotrexate TREXALL; RHEUMATREX Antimetabolites

Methyltestosterone ANDROID Hormonal Oncologics

Mitoxantrone NOVANTRONE Antibiotics-oncologics

Nilotinib TASIGNA Tyrosine kinase inhibitors

Nilutamide NILANDRON Hormonal Oncologics

Ondansetron ZOFRAN Anti-emetic therapy

Oxaliplatin ELOXITIN Alkylating agents

Paclitaxel TAXOL; ONXEL (ABRAXANE3) Antitubulin

Palonosetron (LA) ALOXI Anti-emetic therapy

Pentostatin NIPENT Antimetabolites

Prednisone (in CHOP or CVP) Adjunctive medication

Procarbazine MUTALANE Alkylating agents


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Rituximab RITUXAN Antibodies (mAbs)(CD20)

Romidepsin ISODAX HDAC Inhibitor

Sargramostim (rHuGM-CSF) LEUKINE Growth factor

Sorafenib NEXAVAR Tyrosine kinase inhibitors (VEGF)

Sunitinib SUTENT Tyrosine kinase inhibitors (VEGF)

Tamoxifen NOLVADEX Hormonal Oncologics

Topotecan HYCAMTIN Topoisomerase I inhibitors

Toremifene FARESTON Hormonal Oncologics

Temozolomide TEMODAR Alkylating agents

Trastuzumab HERCEPTIN Antibodies (mAbs) (HER -2neu)

Tretinoin (ATRA= All trans retinoicacid)

RETIN-A; VESANOID Additional hematologic

Vinblastine VELBAN Antitubulin

Vincristine ONCOVIN Antitubulin

Vinorelbine NAVELBINE Antitubulin

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