OMX PROBIOTICS. In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute,...

OMX PROBIOTICS

OMX PROBIOTICS

In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute, discovered that ingestion of certain microorganism can displace putrefactive toxin-producing bacteria… thus preventing (and even treating) diseases, thereby prolonging life and promoting health… (this was noted among Bulgarian farmers)

In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute, discovered that ingestion of certain microorganism can displace putrefactive toxin-producing bacteria… thus preventing (and even treating) diseases, thereby prolonging life and promoting health… (this was noted among Bulgarian farmers)

For the last 20 years, Dr. Iichiroh Ohhira a Japanese Microbiologist, awarded “Scientist of the Year” in 1991 after successfully encapsulating strains of good bacteria known as

“ Probiotics ”.

For the last 20 years, Dr. Iichiroh Ohhira a Japanese Microbiologist, awarded “Scientist of the Year” in 1991 after successfully encapsulating strains of good bacteria known as

“ Probiotics ”.

Develops due to the lost of inhibitoryinfluence of the intestinal microflora.- The Pharmacological Basis of Therapeutics - (Goodman and Gilman)

Super InfectionSuper InfectionSuper InfectionSuper Infection

- Associated after treatment of broad spectrum antibiotics.

Nosocomial InfectionNosocomial InfectionNosocomial InfectionNosocomial Infection

- The presence of large number of non- pathogenic bacteria provides protection to the host by suppressing the growth of potentially pathogenic bacteria.

- Principles of Surgery SWARTZ 7th edition.

OMX PROBIOTICSOMX PROBIOTICSOMX PROBIOTICSOMX PROBIOTICS

Brand Name:Brand Name: OOMXMXBrand Name:Brand Name: OOMXMX

12 Strains of Lactobacillus and Bifidus 12 Strains of Lactobacillus and Bifidus bacteria, 18 Essential and non-essential bacteria, 18 Essential and non-essential amino acids, Vitamins B6, B12, folic acid, amino acids, Vitamins B6, B12, folic acid, niacinamide, panthothenic acid, biotin, niacinamide, panthothenic acid, biotin, inositol, riboflavin, thiamine, Fe++, Ca, k+, inositol, riboflavin, thiamine, Fe++, Ca, k+, phosphorus, Na+.phosphorus, Na+.

12 Strains of Lactobacillus and Bifidus 12 Strains of Lactobacillus and Bifidus bacteria, 18 Essential and non-essential bacteria, 18 Essential and non-essential amino acids, Vitamins B6, B12, folic acid, amino acids, Vitamins B6, B12, folic acid, niacinamide, panthothenic acid, biotin, niacinamide, panthothenic acid, biotin, inositol, riboflavin, thiamine, Fe++, Ca, k+, inositol, riboflavin, thiamine, Fe++, Ca, k+, phosphorus, Na+.phosphorus, Na+.

Origin, Origin, FounderFounder:: OOhhira, hhira, JapanJapanOrigin, Origin, FounderFounder:: OOhhira, hhira, JapanJapan

Ingredients:Ingredients:Ingredients:Ingredients:

Most Reported ProbioticsMost Reported Probiotics

BIFIDOBACTERIABIFIDOBACTERIA• B. bifidumB. bifidum• B. longumB. longum• B. breveB. breve• B. lactisB. lactis

Streptococcus Streptococcus thermophilusthermophilus

LACTOBACILLILACTOBACILLI• L.GGL.GG• L. acidophilusL. acidophilus• L.caseiL.casei• L.bulgaricusL.bulgaricus

Saccahromyces Saccahromyces boulardiiboulardii

EnterecoccusEnterecoccus

faecalisfaecalis

Bacteria comprise 3.5 lbs Bacteria comprise 3.5 lbs of our TBW.of our TBW.Bacteria comprise 3.5 lbs Bacteria comprise 3.5 lbs of our TBW.of our TBW.

30% of fecal material consist 30% of fecal material consist of bacteria.of bacteria.30% of fecal material consist 30% of fecal material consist of bacteria.of bacteria.

Thousands of billions of Thousands of billions of bacteria resides in our bacteria resides in our system.system.

Thousands of billions of Thousands of billions of bacteria resides in our bacteria resides in our system.system.

INTESTINAL FLORA

10^7 bacteria gram of saliva10^7 bacteria gram of saliva

10^3 stomach- gastric acid

10^3 stomach- gastric acid

10^4 jejunum lactobacillus-enterococcus

10^4 jejunum lactobacillus-enterococcus

10^7 ileum mixed flora

10^7 ileum mixed flora

10^12/g ileo-cecal colon bifidus bacteroids strep10^12/g ileo-cecal colon bifidus bacteroids strep

85%85%102 strains102 strains

Good BacteriaGood BacteriaBeneficialBeneficialFriendlyFriendly

SymbioticSymbiotic


Good BacteriaGood BacteriaBeneficialBeneficialFriendlyFriendly

SymbioticSymbiotic


Bad BacteriaBad BacteriaHarmfulHarmful

PathogenicPathogenicOpportunisticOpportunistic


Bad BacteriaBad BacteriaHarmfulHarmful

PathogenicPathogenicOpportunisticOpportunistic

MICROFLORA

Maintain Balance

Positive = Healthy

Negative = Unhealthy

Maintain Balance

Positive = Healthy

Negative = Unhealthy

Prevent colonization and control the growth of pathogenic bacteria

Strengthen immune system and serve as body’s first line of defense.

Produce ATP and vitamins k / B-Complex and helps in the digestion of food and absorption of minerals.

BENEFICIAL FUNCTIONSBENEFICIAL FUNCTIONSBENEFICIAL FUNCTIONSBENEFICIAL FUNCTIONS


Guard against CANCER.

- Friendly bacteria neutralize & metabolize procarcinogens & convert them back into non-carcinogenic substances.

- Decrease the work load of the immune system.

- Increase the activity of tumor killer cells and DNA repair system.

“Probiotics” A Critical Review – Dr. Gerald W. Tannock 1999“Probiotics” The Scientific Basis – Dr. Roy Fuller 1992

Choosing the Right ProbioticsChoosing the Right ProbioticsChoosing the Right ProbioticsChoosing the Right Probiotics

The freeze drying process involves the removal of water by subjecting the bacteria to extremes of heat and cold

and the application of vacuum. This drastic “ripping off” of water from a living organism disrupts its structure,

function and internal environment.




• Addition of stabilizers and preservatives prior to freeze drying.• Severe bacterial cell damage occurs if centrifugation and chemicals are used.• Extensive damage to bacteria caused by freeze drying process.• Powder shelf life is short.• Powder absorbs water, then bacteria become activated and die away.• Live bacteria in the powder have damaged walls and cannot grow properly.• Transport and storage is easier, but must be refrigerated.


POWDERSPOWDERS(free powders and capsules)(free powders and capsules)


LIQUID PREPARATIONS (Yoghurt, etc.)


Liquid preparations offer major disadvantages which relate to the instability of free organisms while in solution, harsh

methods of preparation such as pasteurization, and the corrosive action of the stomach’s acid.



• Short shelf life (few organisms remain alive in solution after several weeks)• Friendly bacteria damaged by pasteurization (exposure to high temperatures 60 to 80 deg. C)• Severe bacterial cell damage occurs if centrifugation and chemicals are used.• Additives and preservatives are added to stabilize the bacteria in solution.• Transport and storage is difficult.• Not suitable for overseas travel.



FERMENTED PASTE CONTAINING

FRIENDLY BACTERIA

FERMENTED PASTE CONTAINING

FRIENDLY BACTERIA

The preparation of OMX involves the use of The preparation of OMX involves the use of natural organic ingredients and a natural non-natural organic ingredients and a natural non-

chemical fermentation process unlike any other chemical fermentation process unlike any other preparation process currently used by industry.preparation process currently used by industry.

- Bacteria-functional and viable. - No damage to bacterial cell wall. - No centrifugation. - No freezing. - Storage and transport is easy. - No preservatives and additives.


Some Local Trials/Evidences on the Use of Probiotics

pro fou nd ly d is tu rb s thein tes tina l ecosys tem

R eferences:1. C olo mbe JF e t al. Lancet. 19872. Vanderhoof JA et al. J Ped iatr. 1 9993. G oodm an & G illm an . Pharmacological B asis of Therapeutics

(1)

(2 )

(3 )

Acute Non-Bloody DiarrheaAcute Non-Bloody DiarrheaCommunity Acquired PneumoniaCommunity Acquired Pneumonia

Allergy – Atopic DermatitisAllergy – Atopic Dermatitis

Dengue Hemorrhagic Fever Grade IIDengue Hemorrhagic Fever Grade IINosocomial InfectionNosocomial Infection

Immune Markers for UndernourishedImmune Markers for Undernourished

* Constipation* Constipation

Febrile NuetropeniaFebrile Nuetropenia* Chronic UTI* Chronic UTI

SummarySummaryProven Effects in (1)diarrhea, Proven Effects in (1)diarrhea,

(2)pneumonia, (3)dengue grade II, (2)pneumonia, (3)dengue grade II, (4)nosocomial infection, (5)allergy (4)nosocomial infection, (5)allergy prevention (6) Immune Markers for prevention (6) Immune Markers for Undernourished at least in the local Undernourished at least in the local

setting.setting.

Cost-effective, safe adjunct in the Cost-effective, safe adjunct in the routine treatment of common pediatric routine treatment of common pediatric

conditionsconditions

Methods of ConsumptionMethods of ConsumptionMethods of ConsumptionMethods of Consumption StorageStorageStorageStorage

Early morning orEarly morning orBefore BedtimeBefore Bedtime

Ideally Empty StomachIdeally Empty Stomach

Early morning orEarly morning orBefore BedtimeBefore Bedtime

Ideally Empty StomachIdeally Empty Stomach

Keep away from heatKeep away from heatAt least room temperatureAt least room temperature

Keep away from heatKeep away from heatAt least room temperatureAt least room temperature

RuChe Philippines

THANK YOUTHANK YOU

Roche P. Ruiz, MBAFOR MORE INFORMATION

GET THROUGH ME @ 0922-8007617

WWW.RUCHEPHILS.COMWWW.RUCHEPHILS.COMWWW.RUCHEPHILS.COMWWW.RUCHEPHILS.COM

PROBIOTICSPROBIOTICSPROBIOTICSPROBIOTICS

““Pro-bio” (Pro-Life)Pro-bio” (Pro-Life)““Pro-bio” (Pro-Life)Pro-bio” (Pro-Life)

A functional food medicine, which A functional food medicine, which beneficially improves and beneficially improves and restores, altered human Intestinal restores, altered human Intestinal Microbial Balance (IMB).Microbial Balance (IMB).

A functional food medicine, which A functional food medicine, which beneficially improves and beneficially improves and restores, altered human Intestinal restores, altered human Intestinal Microbial Balance (IMB).Microbial Balance (IMB).

When taken a substantial amount offers When taken a substantial amount offers beneficial effect on the host. - WHObeneficial effect on the host. - WHOWhen taken a substantial amount offers When taken a substantial amount offers beneficial effect on the host. - WHObeneficial effect on the host. - WHO

It’s a Bacteria!!!It’s a Bacteria!!!It’s a Bacteria!!!It’s a Bacteria!!! GOOD Bacteria.GOOD Bacteria.GOOD Bacteria.GOOD Bacteria.

ROYAL SOCIETY of MEDICINE of ROYAL SOCIETY of MEDICINE of GREAT BRITAIN reported the 90% of GREAT BRITAIN reported the 90% of

ALL illnesses are caused by the ALL illnesses are caused by the Infection of the GASTRO-Infection of the GASTRO-INTESTINAL TRACT (GIT).INTESTINAL TRACT (GIT).

ROYAL SOCIETY of MEDICINE of ROYAL SOCIETY of MEDICINE of GREAT BRITAIN reported the 90% of GREAT BRITAIN reported the 90% of

ALL illnesses are caused by the ALL illnesses are caused by the Infection of the GASTRO-Infection of the GASTRO-INTESTINAL TRACT (GIT).INTESTINAL TRACT (GIT).

90% of ALL illnesses are associated 90% of ALL illnesses are associated with BAD BACTERIAwith BAD BACTERIA

90% of ALL illnesses are associated 90% of ALL illnesses are associated with BAD BACTERIAwith BAD BACTERIA

meaning … “For Life"

It is the opposite of antibiotics or the killing of bacteria.

Dr. Hippocrates (Father of Medicine) SAID

"Let your food be your medicine and your medicine your food".

1941 Antimicrobial Therapy began with the production of antibiotics called penicillin.

1941 Antimicrobial Therapy began with the production of antibiotics called penicillin.

This pharmaceutical agent become the most misuse, abuse & over use.

This pharmaceutical agent become the most misuse, abuse & over use.

Result of the widespread use of antimicrobial agent has been the emergence of antibiotics resistant pathogen and “superinfection” (e.g. pseudomembranous colitis – clostridium dificille)

Result of the widespread use of antimicrobial agent has been the emergence of antibiotics resistant pathogen and “superinfection” (e.g. pseudomembranous colitis – clostridium dificille)

GOODMAN & GILMANGOODMAN & GILMAN

It was discovered by?It was discovered by?It was discovered by?It was discovered by?

Now !!! CalledNow !!! CalledNow !!! CalledNow !!! Called

Lactobacilli Bulgaricus:Lactobacilli Bulgaricus:Lactobacilli Bulgaricus:Lactobacilli Bulgaricus:

Dr. Stamen Dr. Stamen Grigorov Grigorov (Bulgaria 1905)(Bulgaria 1905)

Lactobacilli Casei:Lactobacilli Casei:Lactobacilli Casei:Lactobacilli Casei:

Lactobacilli RhamnosusLactobacilli Rhamnosus also called sometimes L. GG also called sometimes L. GG (Gorbach and Golding)(Gorbach and Golding)

digestive systems lack the enzymes todigestive systems lack the enzymes tobreak down lactose to simpler sugars.break down lactose to simpler sugars.digestive systems lack the enzymes todigestive systems lack the enzymes tobreak down lactose to simpler sugars.break down lactose to simpler sugars.

Lactose Intolerance:Lactose Intolerance:Lactose Intolerance:Lactose Intolerance:

meansmeans “ “MILKMILK””meansmeans “ “MILKMILK””

meansmeans “ACID-LOVING” “ACID-LOVING”meansmeans “ACID-LOVING” “ACID-LOVING”

Bacteria:Bacteria:Bacteria:Bacteria:1. Resident1. Resident1. Resident1. Resident 2. Transient2. Transient2. Transient2. Transient

Lacto ?Lacto ?Lacto ?Lacto ?

Bacillus ?Bacillus ?Bacillus ?Bacillus ? meansmeans “ROD-LIKE in SHAPE” “ROD-LIKE in SHAPE”meansmeans “ROD-LIKE in SHAPE” “ROD-LIKE in SHAPE”

AcidophilusAcidophilusAcidophilusAcidophilus

Bad Bacteria:Bad Bacteria:Bad Bacteria:Bad Bacteria: AlkalineAlkalineAlkalineAlkaline

Good Bacteria:Good Bacteria:Good Bacteria:Good Bacteria: AcidicAcidicAcidicAcidic

Bacterium Genes Bacterium Genes (Genus)(Genus)Bacterium Genes Bacterium Genes (Genus)(Genus)1. Lactobacilli1. Lactobacilli1. Lactobacilli1. Lactobacilli 2. Bifidobacterium2. Bifidobacterium2. Bifidobacterium2. Bifidobacterium

3. Streptococcus3. Streptococcus3. Streptococcus3. Streptococcus4. Enterococcus4. Enterococcus4. Enterococcus4. Enterococcus

The large intestine houses the greatest number and the widest assortment.

is the main bacteria that resides in the is the main bacteria that resides in the Small Bowel.Small Bowel.is the main bacteria that resides in the is the main bacteria that resides in the Small Bowel.Small Bowel.

Lactobacillus AcidophilusLactobacillus Acidophilus

is a traveling bacteria that aids acidophilus is a traveling bacteria that aids acidophilus and bifidus.and bifidus.is a traveling bacteria that aids acidophilus is a traveling bacteria that aids acidophilus and bifidus.and bifidus.

Lactobacillus BulgaricusLactobacillus Bulgaricus

is the main bacteria that resides in the is the main bacteria that resides in the COLON?COLON?is the main bacteria that resides in the is the main bacteria that resides in the COLON?COLON?

BifidusBifidus

OMX PROBIOTICSOMX PROBIOTICSOMX PROBIOTICSOMX PROBIOTICS

Brand Name: OMXBrand Name: OMX

12 Strains of Lactobacillus and Bifudus bacteria, 18 Essential and non-essential amino acids, Vitamins B6, B12, folic acid, niacinamide, panthothenic acid, biotin, inositol, riboflavin, thiamine, Fe++, Ca, k+, phosphorus, Na+.

12 Strains of Lactobacillus and Bifudus bacteria, 18 Essential and non-essential amino acids, Vitamins B6, B12, folic acid, niacinamide, panthothenic acid, biotin, inositol, riboflavin, thiamine, Fe++, Ca, k+, phosphorus, Na+.

Origin, Founder: Ohhira, JapanOrigin, Founder: Ohhira, Japan

Ingredients:Ingredients:

is a LIVE microbial food medicine which beneficially improves and maintain human intestinal microbial balance.

is a LIVE microbial food medicine which beneficially improves and maintain human intestinal microbial balance.

Definition by the FAO/WHO “live microorganisms which when consumed in ADEQUATE AMOUNTS, confer a health effect on the host.

Definition by the FAO/WHO “live microorganisms which when consumed in ADEQUATE AMOUNTS, confer a health effect on the host.

Group of bacteria

inhabits the intestine

Group of bacteria

inhabits the intestine

100 trillion bacteria of

400 different strains

100 trillion bacteria of

400 different strains

30% of feces are bacteria30% of feces are bacteria

3.5 lbs TBW are bacteria 3.5 lbs TBW are bacteria

INTESTINAL FLORA

Prevent colonization and control the growth of pathogenic bacteria

Strengthen immune system and serve as body’s first line of defense.

Produce ATP and vitamins k / B-Complex and helps in the digestion of food and absorption of minerals.











POWDERSPOWDERS(free powders and capsules)(free powders and capsules)


FERMENTED PASTE FERMENTED PASTE CONTAINING CONTAINING

FRIENDLY BACTERIAFRIENDLY BACTERIA

FERMENTED PASTE FERMENTED PASTE CONTAINING CONTAINING

FRIENDLY BACTERIAFRIENDLY BACTERIA

The preparation of OMX involves the use of natural organic ingredients and a natural non-

chemical fermentation process unlike any other preparation process currently used by industry.

The preparation of OMX involves the use of natural organic ingredients and a natural non-

chemical fermentation process unlike any other preparation process currently used by industry.



STRESSFUL LIFESTYLE STRESSFUL LIFESTYLE

FOOD – HERBICIDES, PESTICIDES, CHEMICAL, PRESEVATIVES

FOOD – HERBICIDES, PESTICIDES, CHEMICAL, PRESEVATIVES

GASTRO-INTESTINAL DISORDER GASTRO-INTESTINAL DISORDER

RADIATION THERAPY RADIATION THERAPY

ANTIBIOTICS/CHEMOTHERAPY ANTIBIOTICS/CHEMOTHERAPY

Migraine Headache / Hypertension- bad bacteria produce Tyramine.- Tyramine triggers constriction of blood vessel.

Chronic Oral Ulcer- Oral microbial balance destroyed by Antibiotics / Steroids / Chlorinated water / Chemicals &

Pesticides – leads to depletion of Lactobacillus Salivaricus (good bacteria)

Peptic Ulcer Disease- Helicobacter Pylori – a pathogenic bacteria destroy the mucosal lining of the stomach.- acid can easily penetrate the eroded mucusa-producing ulcer

Coronary Heart Disease- Studies showed that DNA protein of chlamydia pneumonia

was found underneath the cholesterol plaque-atheroma of coronary artery.

(British Journal of Cardiology)Gall Bladder Stone- E. Coli dis-conjugates bilirubin into insoluble bile. And

theis serves as a Nidus for stone formation.

Kidney Stone - Nano bacteriaKidney Stone - Nano bacteria

Diabetes Mellitus- E. coli toxins block the receptor site, which makes the insulin inactive.

Alzheimer’s Disease- E. coli bacteria forms fibers made up of amyloid, substance

that makes up the plaques that accumulate in the brain. (Dr. Matthew R. Chapman – Washington University)

Hypertyroidisma- Yersinia enterocolitica – a bad bacteria from intestine was found in the thyroid gland of those patients suffering from

thyroid disease.

Chronic U.T.I.- Depletion of Doderlie Bacillus.- Imbalance of intestinal microbial flora may also lead to

chronic U.T.I. secondary to its anatomical proximity to the anus.Diarrhea - Transient pathogenic bacteria from contaminated food.

* Acidification of Gut Lumen

* Synthesis of Antimicrobial substances

* Competition for Nutrients

* Competition for Receptors

* Competitive Inhibition of Adhesion of Pathogen

* Modification of Toxins or Toxins Receptors

* Stimulation of Specific and Non-Specific Immune Response

MECHANISM OF ACTIONSMECHANISM OF ACTIONS

Some Local Trials/Evidences on the Use of Probiotics

Acute Non-Bloody Diarrhea

Community Acquired Pneumonia

Allergy – Atopic Dermatitis

Dengue Hemorrhagic Fever Grade II

Nosocomial Infection

Immune Markersfor Undernourished

* Constipation

Febrile Nuetropenia

* CHRONIC U.T.I.

Acute Non-Bloody DiarrheaAcute Non-Bloody Diarrhea

Intake of OMX Probiotics capsules (1 capsule BID for 5 days) Intake of OMX Probiotics capsules (1 capsule BID for 5 days) In addition to ORS, significantly reduced the duration ofIn addition to ORS, significantly reduced the duration ofDiarrhea in children compared with those who only receivedDiarrhea in children compared with those who only receivedORS. The mean days were shorter 3.17 days in the probioticORS. The mean days were shorter 3.17 days in the probioticGroup than in non-probiotic group with 5.12 daysGroup than in non-probiotic group with 5.12 days

Intake of OMX Probiotics capsules (1 capsule BID for 5 days) Intake of OMX Probiotics capsules (1 capsule BID for 5 days) In addition to ORS, significantly reduced the duration ofIn addition to ORS, significantly reduced the duration ofDiarrhea in children compared with those who only receivedDiarrhea in children compared with those who only receivedORS. The mean days were shorter 3.17 days in the probioticORS. The mean days were shorter 3.17 days in the probioticGroup than in non-probiotic group with 5.12 daysGroup than in non-probiotic group with 5.12 days

Jose Reyes Memorial Medical Center

Community acquired pneumoniaCommunity acquired pneumonia

Intake of OMX Probiotics capsules significantly shortened theIntake of OMX Probiotics capsules significantly shortened theDuration of illness (cough, fever, rales, retractions, wheezing)Duration of illness (cough, fever, rales, retractions, wheezing)Hospital stay and respiratory symptoms with mean of 2.4 daysHospital stay and respiratory symptoms with mean of 2.4 daysIn the treatment group vs. 4.3 days in the control group.In the treatment group vs. 4.3 days in the control group.(1-2 capsules 2x a day)(1-2 capsules 2x a day)

Intake of OMX Probiotics capsules significantly shortened theIntake of OMX Probiotics capsules significantly shortened theDuration of illness (cough, fever, rales, retractions, wheezing)Duration of illness (cough, fever, rales, retractions, wheezing)Hospital stay and respiratory symptoms with mean of 2.4 daysHospital stay and respiratory symptoms with mean of 2.4 daysIn the treatment group vs. 4.3 days in the control group.In the treatment group vs. 4.3 days in the control group.(1-2 capsules 2x a day)(1-2 capsules 2x a day)


Allergy – atopic dermatitisAllergy – atopic dermatitis

Intake of Probiotics resulted to a lower score on the SCORADIntake of Probiotics resulted to a lower score on the SCORAD(SCORing Atopic Dermatitis) index, a clinical tool used to(SCORing Atopic Dermatitis) index, a clinical tool used toObjectively assess atopic dermatitis. 46% less incidence withObjectively assess atopic dermatitis. 46% less incidence withProbiotics than 56% without.Probiotics than 56% without.

Intake of Probiotics resulted to a lower score on the SCORADIntake of Probiotics resulted to a lower score on the SCORAD(SCORing Atopic Dermatitis) index, a clinical tool used to(SCORing Atopic Dermatitis) index, a clinical tool used toObjectively assess atopic dermatitis. 46% less incidence withObjectively assess atopic dermatitis. 46% less incidence withProbiotics than 56% without.Probiotics than 56% without.


Nosocomial infectionNosocomial infection

Preliminary results: Intake of Probiotic capsules preventPreliminary results: Intake of Probiotic capsules preventnosocomial infection in Children with hematologic andnosocomial infection in Children with hematologic andOncologic Diseases.Oncologic Diseases.

Preliminary results: Intake of Probiotic capsules preventPreliminary results: Intake of Probiotic capsules preventnosocomial infection in Children with hematologic andnosocomial infection in Children with hematologic andOncologic Diseases.Oncologic Diseases.

Philippine General Hospital

Intake of OMX Probiotics did not progress to further deterio-Intake of OMX Probiotics did not progress to further deterio-Ration of their condition and were able to have normalizationRation of their condition and were able to have normalizationof their Hematocrit and platelet count. HCT 3,94 (controlof their Hematocrit and platelet count. HCT 3,94 (controlgroup) and 2.16 days (experimental group) Platelet Count 5.50group) and 2.16 days (experimental group) Platelet Count 5.50(control group) & 3.33 days (experimental group) 1-2 caps/days)(control group) & 3.33 days (experimental group) 1-2 caps/days)

Intake of OMX Probiotics did not progress to further deterio-Intake of OMX Probiotics did not progress to further deterio-Ration of their condition and were able to have normalizationRation of their condition and were able to have normalizationof their Hematocrit and platelet count. HCT 3,94 (controlof their Hematocrit and platelet count. HCT 3,94 (controlgroup) and 2.16 days (experimental group) Platelet Count 5.50group) and 2.16 days (experimental group) Platelet Count 5.50(control group) & 3.33 days (experimental group) 1-2 caps/days)(control group) & 3.33 days (experimental group) 1-2 caps/days)

OMX Probiotics lead to weight gain and shorterOMX Probiotics lead to weight gain and shorterduration of infections.duration of infections.OMX Probiotics lead to weight gain and shorterOMX Probiotics lead to weight gain and shorterduration of infections.duration of infections.

Philippine Children Medical Center

Dengue Hemorrhagic Fever Grade II

Immune Markersfor Undernourished


* Constipation

Febrile Nuetropenia

* Chronic u.t.i.

Cardinal Santos Medical Center



Summary Proven Effects in (1)diarrhea, (2)pneumonia, (3)dengue grade II, (4)nosocomial infection, (5)allergy

prevention (6)Undernourished at least in the local setting.

Cost-effective, safe as adjunct in the routine treatment of common

pediatric conditions

Role in IllnessesRole in Illnesses


Allergy Allergy is on the rise in industrialized nations. It is estimated that the incidence of asthma in the Philippines doubled between 1980 and 2000.

The hypothesis suggests that the exposure of infants to microbes before the age of six months helps the immune system mature to be more tolerant of exposure to allergens later in life. Increasing exposure to microbes must be done safely.

The effects of a Lactobacillus strain on incidence of atopic eczema in 132 infants at high risk of developing eczema.


Pregnant mothers two-to-four weeks before delivery and newborn babies through six months of age were given Lactobacillus rhamnosus GG.

Infants were followed through two years of age and incidence of recurring atopic eczema was recorded.

The study reported a 50% drop in incidence of recurring atopic eczema in the group receiving the probiotic supplement.


A follow up study of these same children indicated that these same trends were still present at 4 years of age. These results suggest that exposure to the right types of microbes early in life may decrease the risk of allergy.


Elevated Blood CholesterolElevated Blood Cholesterol. Cholesterol is essential for many functions in the human body. It acts as a precursor to certain hormones and vitamins and it is a component of cell membranes and nerve cells.

But, elevated levels of total blood cholesterol or other blood lipids are considered risk factors for developing coronary heart disease.


Researchers found that the bacteria actually can help control serum cholesterol in two ways.

First, as the bacteria grow in the intestinal tract, they take up some of the cholesterol that is present, and it becomes associated with the cells as the bacteria grow.

Second, at least part of the cholesterol actually becomes incorporated into the bacterial cells. Either way, the cholesterol becomes unavailable for absorption from the intestine into the blood.


Probiotic cultures have been evaluated for their effect on serum cholesterol levels.

Clinical studies on the effect of lowering cholesterol or (LDL) low-density lipid levels in humans. There have been human studies that suggest that blood cholesterol levels can be reduced by consumption of probiotic-containing dairy foods by people with elevated blood cholesterol.


Helicobacter pyloriHelicobacter pylori is a bacterium which colonizes the stomach and can cause gastric ulcers and gastric cancer. The effect of probiotics on H. pylori has been studied. Mechanistic studies in laboratory assays or in animal models have shown that antibacterial substances including (but not limited to) organic acids produced by some lactobacilli inhibit the growth and survival of this pathogen.

Results in humans suggest that some probiotic strains or milk fermented with a probiotic strain can reduce metabolic activity or colonization by H. pylori.


Probiotics have also been used to manage side effects of triple antibiotic therapy used to treat Helicobacter pylori infections.

In these studies, the use of probiotics decreases the side effects of antibiotics, improves patient compliance with taking the prescribed therapy, and increases the rate at which Helicobacter pylori is eradicated (Lionetti et al. 2006; Myllyluoma et al. 2005; Sheu et al. 2006; Sykora et al. 2005).


Irritable bowel syndrome (IBS)Irritable bowel syndrome (IBS) is a functional bowel disorder that can be characterized by symptoms of abdominal pain, cramps, gas, bloating, diarrhea and constipation. Surveys estimate the prevalence rate ranging from 10-20% of the adult population and the condition is diagnosed 3 times more often in women than men (FDA Consumer Magazine, July-Aug, 2001).


It shows controlled studies that have been conducted evaluating probiotics and IBS (Ringel-Kulka T, Ringel Y. Probiotics in irritable bowel syndrome: has

the time arrived? Gastroenterology. 2007 Feb;132(2):813-6). Some symptom relief (primarily from diarrhea or abdominal pain or bloating) has been reported in studies published to date (Whorwell PJ, Altringer L, Morel J, Bond Y, Charbonneau D, O'Mahony L, Kiely B, Shanahan F, Quigley EM. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol. 2006 Jul;101(7):1581-90.).


Inflammatory bowel diseasesInflammatory bowel diseases such as “Ulcerative Colitis” and “Crohn’s disease”, are serious intestinal diseases that can lead to the surgical removal of the colon. The cause of these diseases is not known but it has been hypothesized that an intolerance to the normal microbiota in the gut leads to inflammation and resulting pathology. The role of gut flora in the progression of these diseases has led some researchers to study the impact certain probiotic bacteria might have on maintaining the state of reduced inflammation that occurs during remission stages of the diseases.

This bacterium thrives in more acidic environments This bacterium thrives in more acidic environments than most related microorganisms than most related microorganisms (pH 4-5 or lower)(pH 4-5 or lower) and grows best at 45 degrees Celsius.and grows best at 45 degrees Celsius.


Lactobacillus acidophilus occurs naturally in Lactobacillus acidophilus occurs naturally in the human intestine, mouth, and vagina.the human intestine, mouth, and vagina.Lactobacillus acidophilus ferments lactose into Lactobacillus acidophilus ferments lactose into lactic acid. Lactobacillus acidophilus itself lactic acid. Lactobacillus acidophilus itself ((a

homofermentative microorganism) produces only lactic produces only lactic acid. acid.

Like many bacteria, Lactobacillus acidophilus Like many bacteria, Lactobacillus acidophilus can be killed by excess heat, moisture, or direct can be killed by excess heat, moisture, or direct sunlight.sunlight.

Lactobacillus bulgaricus is one of several Lactobacillus bulgaricus is one of several bacteria used for the production of yogurt. First bacteria used for the production of yogurt. First identified in 1905 by the Bulgarian identified in 1905 by the Bulgarian Dr. Stamen Dr. Stamen GrigorovGrigorov, it is named after Bulgaria., it is named after Bulgaria.


The bacterium feeds on milk and produces lactic The bacterium feeds on milk and produces lactic acid which also helps to preserve the milk. It breaks acid which also helps to preserve the milk. It breaks down lactose and is often helpful to sufferers of down lactose and is often helpful to sufferers of lactose. While fermenting milk, Lactobacillus lactose. While fermenting milk, Lactobacillus bulgaricus produces acetaldehyde, which perfumes bulgaricus produces acetaldehyde, which perfumes yogurt. Some of the biggest importers of the yogurt. Some of the biggest importers of the bacterium are Japan, USA and the EU.bacterium are Japan, USA and the EU.

Lactobacillus RhamnosusLactobacillus Rhamnosus

Lactobacillus RhamnosusLactobacillus Rhamnosus

Lactobacillus casei is a transient, anaerobic microorganism of genus Lactobacillus found in the human intestine and mouth. As a lactic acid producer, it has been found to assist in the propagation of desirable bacteria. This particular species of lactobacillus is documented to have a wide pH and temperature range, and complements the growth of Lactobacillus acidophilus, a producer of the enzyme amylase (a carbohydrate-digesting enzyme).

Lactobacillus casei is a transient, anaerobic microorganism of genus Lactobacillus found in the human intestine and mouth. As a lactic acid producer, it has been found to assist in the propagation of desirable bacteria. This particular species of lactobacillus is documented to have a wide pH and temperature range, and complements the growth of Lactobacillus acidophilus, a producer of the enzyme amylase (a carbohydrate-digesting enzyme).

It is known to improve digestion and reduce milk intolerance and constipation.It is known to improve digestion and reduce milk intolerance and constipation.

Lactobacillus HelveticusLactobacillus Helveticus

Lactobacillus HelveticusLactobacillus Helveticus

Lactobacillus helveticus is a homofermentative thermophilic lactic acid bacterium. Our data contribute to the description of microbial heterogeneity in Lactobacillus helveticus and provide a more solid basis for understanding the functional and ecological significance of the presence of different Lactobacillus helveticus biotypes in natural dairy starter cultures.

This bacterium works as a support in all the group and it has significantly powerful in terms of assistance.

Lactobacillus FermentumLactobacillus Fermentum

Bifidobacterium LongumBifidobacterium Longum

Lactobacillus FermentumLactobacillus Fermentum

Lactobacillus fermentum was selected for further study, since, in addition to its intrinsically high adhesion rate, this organism was found to exhibit a “preferential binding” to the follicle-associated epithelium of the Peyer's patches compared with its level of binding to the mucus-secreting regions of the small intestine.

Kulani

Lactobacillus PlantarumLactobacillus Plantarum

Lactobacillus plantarum is a widespread member of the genus Lactobacillus. It is in saliva (from which

it was first isolated).

Lactobacillus PlantarumLactobacillus Plantarum

It has the ability to liquefy gelatin.

Lactobacillus plantarum has one of the largest genomes known among the lactic acid bacteria and is a very flexible and versatile species.

Bifidobacterium BifidusBifidobacterium Bifidus

Bifidus (Bifodobacterium bifidum) lowers the pH of the intestine, manufactures specific B vitamins, promotes immune function, and supports the health of the large intestine (colon).

Bifidobacterium BifidusBifidobacterium Bifidus

Good intestinal flora in the large intestine can help inhibit gas and bloating.

Bifidus is a natural inhabitant of the large intestine that helps with the absorption of water from food and the processing of remaining waste.

Bifidobacterium InfantisBifidobacterium Infantis

Bifidobacterium LongumBifidobacterium Longum

Scientists have sequenced the genome of one of the most important residents in the human gastrointestinal tract, a bacterium that keeps the digestive system running smoothly, blocks the growth of harmful bacteria, and boosts the immune system. The microbe, called Bifidobacterium longum, is often the dominant bacterium found in humans.

Bifidobacterium BreveBifidobacterium Breve

Bifidobacterium BreveBifidobacterium Breve

Bifidobacteria are natural inhabitants of the human gut microbiota, representing up to 91% of the total gut population in breast-fed babies. Some strains of the genus Bifidobacterium are considered probiotics and can exert several health-promoting effects. Bifidobacterium breve is one of the species more often found in infants.

The intestinal microbiota is continuously exposed to cytotoxic agents, including antibiotics. Recent evidence indicates that Bifidobacterium breve is generally more resistant to antibiotics than other Bifidobacterium species

Bifidobacterium LactisBifidobacterium Lactis

Effects of Bifidobacterium lactis Bb12 Supplementation on Intestinal Microbiota of Preterm Infants: a Double-Blind, Placebo-Controlled, Randomized Study. J Clin Microbiol. 2006 November; 44(11): 4025–4031.

Bifidobacterium LactisBifidobacterium Lactis

Streptococcus ThermophilusStreptococcus Thermophilus

Streptococcus ThermophilusStreptococcus Thermophilus

Streptococcus thermophilus (official name Streptococcus salivarius subsp. thermophilus). It is also classified as a lactic acid bacterium (LAB). Streptococcus thermophilus is found in milk and milk products. (it does not survive the stomach) and generally used in the production of yogurt.

Streptococcus thermophilus (official name Streptococcus salivarius subsp. thermophilus). It is also classified as a lactic acid bacterium (LAB). Streptococcus thermophilus is found in milk and milk products. (it does not survive the stomach) and generally used in the production of yogurt.

Restore improves and maintain the intestinal Restore improves and maintain the intestinal microbial balance , after antibiotics, microbial balance , after antibiotics, chemotherapy, radiotherapy and other factors chemotherapy, radiotherapy and other factors that alter the Intestinal flora. that alter the Intestinal flora. ““One (1) to three (3) capsule per day”One (1) to three (3) capsule per day”

Restore improves and maintain the intestinal Restore improves and maintain the intestinal microbial balance , after antibiotics, microbial balance , after antibiotics, chemotherapy, radiotherapy and other factors chemotherapy, radiotherapy and other factors that alter the Intestinal flora. that alter the Intestinal flora. ““One (1) to three (3) capsule per day”One (1) to three (3) capsule per day”

Antibiotics you need more Probiotics.Antibiotics you need more Probiotics.Why?Why? Along with killing the pathogenic bacteria, antibiotic destroy The balance by destroying good bacteria in your digestive system. “Ideally, you should start repopulating your digestive system with good good bacteria-probioticsbacteria-probiotics when you begin your course of antibiotics.”

Antibiotics you need more Probiotics.Antibiotics you need more Probiotics.Why?Why? Along with killing the pathogenic bacteria, antibiotic destroy The balance by destroying good bacteria in your digestive system. “Ideally, you should start repopulating your digestive system with good good bacteria-probioticsbacteria-probiotics when you begin your course of antibiotics.”

THERAPEUTIC USESTHERAPEUTIC USES

BACTERIA TYPE SOURCE ANTIBIOTIC(S) PRODUCED

BIFIDOBACTERIUM BIFIDUM

RESIDENT BIFIDO-ENRICHED MILK SUPPLEMENTS

BIFIDIN

LACTOBACILLUS ACIDOPHILUS

RESIDENT ADIDOPHILLUS ENRICHED MILK SUPPLEMENTS

ACIDOLIN, ACIDOPHILIN, LACTOBACILLIN, LACTOCIDIN

LACTOBACILLUS BREVIS

TRANSIENT MILK, KEFIR, CHEESE, SAUERKRAUT

LACTOBREVIN

LACTOBACILLUS BULGARICUS

TRANSIENT YOGURT, CHEESE SUPPLEMENTS

BULGARICAN

STRETOCOCCUS LACTIS

TRANSIENT RAW MILK RAW MILK PRODUCTS, CHEESE, COTTAGE CHEESE, BUTTERMILK

NISIN

OMX PROBIOTICS. In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute,...

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Transcript of OMX PROBIOTICS. In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute,...