Oleg Kulikov Research Summary 2016-short
-
Upload
oleg-kulikov -
Category
Documents
-
view
30 -
download
1
Transcript of Oleg Kulikov Research Summary 2016-short
PhD Oleg V. Kulikov Research Summary ([email protected])
POLYMERS CHEMISTRY & PDA NANO-TUBES
UT Dallas, Chemistry Department, Richardson, TX, with Profs. Bruce Novak and Ray Baughman
(2013-current)
Project 1: TMAFM/SEM inspection of the fibrous aggregated morphologies and other complex architectures self-
assembled from helical (R)-and (S)-triazolepolycarbodiimides
Project 2: Copolymerization of triazole-functionalized carbodiimides (R- and S-) with styrene
1). R-50-TRZinsol.
-50-Ph-STYR(1:50)-DMF, 90-95o
C;
2). R-50-TRZinsol.
-50-Ph-STYR(1:100)-DMF, 90-95o
C;
3). S-30-TRZinsol.
-70-Ph-STYR(1:100)-DMF, 90-95o
C;
4). S-30-TRZinsol.
-70-Ph-STYR(1:50)-DMF, 90-95o
C;
5). S-30-TRZinsol.
-70-Ph-STYR(1:100)-DMF, 90-95o
C;
6). S-85-TRZ-15-Ph-STYR(1:50)-DMF, 90-95o
C;
7). S-85-TRZ-15-Ph-STYR(1:100)-DMF, 90-95o
C;
8). S-70-TRZ-30-Ph-STYR(1:50)-DMF, 90-95o
C;
9). S-100-TRZ-STYR(1:50)-toluene, 90-95o
C;
10). S-100-TRZ-STYR(1:50)-DMF, 80-82o
C;
11). S-70-TRZ-30-Ph-STYR(1:50)-DMF, 90-95o
C;
12). R-50-TRZ-50-Ph-STYR(1:50)-DMF, 90-95o
C;
13). R-50-TRZ-50-Ph-STYR(1:50)-toluene, 95o
C;
14). S-50-TRZ-50-Ph-STYR(1:50)-toluene, 95o
C;
15). S-30-TRZsol.
-70-Ph-STYR(1:50)-toluene, 84-92o
C;
16). R-30-TRZsol.
-70-Ph-STYR(1:50)-toluene, 90-100o
C;
17). R-30-TRZinsol.
-70-Ph-STYR(1:50)-toluene, 90-95o
C;
18). R-30-TRZsol.
-70-Ph-STYR(1:50)-DMF, 95o
C;
19). R-30-TRZinsol.
-70-Ph-STYR(1:50)-DMF, 90-95o
C;
20). R-15-TRZsol.
-85-Ph-STYR(1:100)-DMF, 90-95o
C;
21). S-15-TRZsol.
-85-Ph-STYR(1:100)-DMF, 90-95o
C;
22). R-15-TRZsol.
-85-Ph-STYR(1:50)-DMF, 90-95o
C;
23). S-15-TRZsol.
-85-Ph-STYR(1:50)-DMF, 90-95o
C;
24). R-15-TRZsol.
-85-Ph-STYR(1:50)-DMF, 63-67o
C,1d;
25). S-15-TRZsol.
-85-Ph-STYR(1:50)-DMF, 63-72o
C,1d;
26). S-30-TRZsol.
-70-Ph-STYR(1:50)-DMF, 60-62o
C,1d;
27). R-30-TRZsol.
-70-Ph-STYR(1:50)-DMF, 57-65o
C,6hr;
28). R-85-TRZsol.
-15-Ph-STYR(1:50)-DMF, 55-60o
C,6hr;
29). R-85-TRZsol.
-15-Ph-STYR(1:50)-DMF, 55-60o
C,1d
Project 3: Synthesis of diacetylenes and their transformation to the ladder-type polymers
UV-induced polymerization
BIOORGANIC/SUPRAMOLEULAR CHEMISTRY
University of Pennsylvania, Chemistry Department, Philadelphia, PA, with Prof. Virgil Percec (2012)
Project: Dendritic molecules – synthesis of Janus dendrimers via modular protocol, modeling studies,
formation of vesicles for the protein binding applications
MEDICINAL CHEMISTRY
Yale University, Chemistry Department, New Haven, CT, with Prof. Andrew Hamilton (2009-2011)
Project 1: Novel non-natural oligoamides as potential alpha-helix mimetics
Vesicles self-assembly in aqueous media
Canonical α-helix with side chain residues and proposed benzamide trimer to target RhoGEF domain
Project 2: Design and synthesis of oligoamide-based double alpha-helix mimetics
Schematic representation of double helix mimetic with side chains (a) and protein double alpha helix (b)
MACROCYCLIC/BIOORGANIC/SUPRAMOLEULAR CHEMISTRY
UMSL, Chemistry Department, St. Louis, MO with Prof. George Gokel (2007-2009)
Project: Supramolecular nano-capsules, metal organic nano-capsules (MONCS), “bilayers” and nano-
tubes derived from pyrogallol[4]arenes for drug delivery and ion transport applications
Cu-MONC`s
R = Me, C3H7, C6H13, C8H17 – C13H27, CH2=CH-(CH2)8-,
cyclohexyl-, Ph, p-C6H4Br, isopropyl-, 2-butyl-, 3-pentyl,
4-heptyl-, 5-nonyl-, 2-pentyl-, 3-heptyl
Ion-conducting properties of capsules and nano-tubular arrangements
Cu-MONC`s
Small drug molecules such as Diazepam (magenta) may be captured within hydrophobic pockets formed by long aliphatic chains of capsule and then released (enzymatic or photochemical mechanism)
MACROCYCLIC CHEMISTRY
NCSU, Chemistry Department, Raleigh, NC with Prof. Jonathan Lindsey (2006-2007)
Project: “Molecular Information Storage” – developing porphyrins for molecular electronic applications
SMALL HETEROCYCLES/MACROCYCLIC CHEMISTRY
A.V. Bogatsky Physico-Chemical Institute, Odessa, Ukraine, PhD Thesis “Synthesis, structure and properties
of 2-aminobenzophenones oximes and their derivatives”, 2006 with Prof. Sergey Andronati
Anti-aggregation activity data for oximes
(ACSA = acetylsalicylic acid)
General approach to the synthesis of 16-membered
azomacrocycles An alternative route A
An alternative route B
Synthesis of 18-membered azamacrocycles