Office of International

Affairs

12/4/2019 1www.uohyd.ernet.in

About the OIA

Office headed by Director, International Affairs and managed by Private Secretary to the Director.

University of Hyderabad has several MoUs with various Universities of high repute across the globe.

Some of the countries include:

USA—University of Illinois at Springfield, University of Iowa, Portland State University

Germany—University of Muenster; University of Wurzburg, Freie University

Canada—University of Alberta,

Sweden—Linnaeus University

Ongoing and upcoming Activities:

University of Bordeaux, France (27-11-2019)

University of Saskatchewan, Saskatoon, Canada (03-12-2019)

Visit of delegation from University of Auckland, New Zealand on December 4, 2019

International Research Training Groups: University of Muenster, Freie University, Germany

Two independent New Passage to India program that facilitates exchange of Students and Faculty on both sides.

12/4/2019 3www.uohyd.ernet.in

Australian National University (Future Research Talent Awards—10-12 week research experience in the fields of Science, Health and Medicine during May-August 2020

Australia Awards Scholarships to pursue Masters program at Australian Universities. Two students were selected to pursue Masters program at University of Melbourne. to work at Women’s Studies

Study India Program an initiative of the Ministry of Human Resource Development-admission through SII portal to study various courses/pograms.

Scheme for Promotion of Academic and Research Collaboration (SPARC)—specific research projects with international universities that have QS rankings below 500. University of Hyderabad has been identified as Nodal Institute for Brazil.

DUO-INDIA program for Faculty and Student Exchange between UoH and 14 countries in Europe

Activities

12/4/2019 4www.uohyd.ernet.in

Some statistics about International Students pursuing various courses:

At any given point of time 50 international students (both Masters and Ph.D.) are enrolled at the University. The students come from—Afghanistan, Bangladesh, Ghana, Guyana, Ethiopia, Iran, Thailand, Syria, South Africa, Yemen, USA

International Students

12/4/2019 5www.uohyd.ernet.in

School of Life SciencesUniversity of Hyderabad

(Website: sls.uohyd.ac.in)

School of Life Sciences (1977)

Dept of Animal

Biology

Dept of

Biochemistry

M. Sc. Biotechnology

M.Tech. Bioinformatics

Int. PhD & Ph D in Biotechnology

UGC Special Assistance,

COSIST,DRS; DST- FIST

Dept of

Biotechnologysince 2008

Depts since 1993

Multidisciplinary, with several courses and

intense research activities

M. Sc. Biochemistry

Ph. D. Biochemistry

Dept of Plant

Sciences

M. Sc. Plant Biology &

Biotechnology

M.Sc Molecular

Microbiology

Ph. D. Plant Science

Workshops & Refresher Courses

M. Sc. Animal Biology &

Biotechnology

Ph. D. Animal Science

Center for Systems

Biology

5yr IMSc in

Systems Biology

Infrastructural Facilities

❖Genomics, proteomics, metabolomics, live celland live animal imaging facility, confocalmicroscope, SEM & TEM, High endcomputational facilities, etc.

❖Radiation Facility

❖Biosafety level-3 facility for small animals and reasonably well established animal house

❖Green House Facilities

❖Seminar hall with 200 seating and auditorium with 600 seating.

Training Workshops: Proteomics and Genomics,

including Microarraysfor Ph. D. Students & Post-docs from UoH as well as outside

Expenditure for infrastructure and recurring expenses were

met from the grants of SAP-CAS & DBT-CREBB

Workshops & Training Programs

❖Global Initiative of Academic Networks (GIAN)

workshops involving industry representatives• Cancer Drug Discovery and Development;

• Immunologicals in Animal and Human Health;

• Ion Channels in Human Diseases;

• Lipid Signaling in Health and Disease in Animals and Plants;

• Stem Cells and Regenerative Medicine

• Protein Structure and Drug Discovery

• Glycoconjugates-Role in Biology and Biomedical Relevance

• Total of 10 GIAN Programs have been conducted and some more are

under active consideration.

Indian Immunologicals

Dr Reddy’s Research Labs

Natco Pharma

Shantha Biotech

Dabur Research Foundation

Aurobindo Pharma

Atul Ltd.

Nagarjuna Fertilisers and Chemicals Ltd. (NFCL)

Onconova Therapeutics

Laila Impex

Sree Biotech Pvt Ltd

Krishna Agro Pvt Ltd

Biological E Ltd.

Biosin, Unique Biotech Ltd.

Interactions with Industry

Bulk Drugs manufacturing Association

Biosafety Level-3 (BSL-3)

FACILITY

BIRAC Sponsored BioNEST

(Bioincubators Nurturing Entrepreneurship for scaling Technologies)

❖ Objectives

❖To foster entrepreneurship initiatives in the area of

biotechnology at University of Hyderabad (UoH).

❖Creation of state-of-art infrastructure and intellectual

resources, IPR and entrepreneurship environment for

budding entrepreneurs.

❖ Key Goals

❖To tap innovations & ideas

❖Converting ideas/innovations to prototypes

❖Scaling of prototypes to marketable products

❖The proposed UoH-BioNEST will focus on new as well

as emerging technologies, multidisciplinary and

translational research in the areas of Biology and

Biotechnology

Publications in High Impact Factor JournalsNature 42.35

Science 34.66

Nature Reviews Microbiology 21.182

Progress in Lipid Research 14.23

Trends in Plant Sciences 11.047

Trends in Biotechnology

Seminars in Cancer biology

9.148

9.955

Nucleic Acid Research 9.11

Critical Reviews in Biochemistry & Molecular Biology 7.655

Plant Physiology 7.054

Critical Reviews in Biotechnology 6.472

Oncogene 6.373

Critical Reviews in Microbiology 6.270

Molecular Biology of the Cell 5.98

The FASEB Journal 5.712

Scientific Reports 5.6

Journal of Lipid Research 5.559

Journal of Experimental Botany 5.364

Plant, Cell & Environment 5.215

Biochimica et Biophysica Acta 5.000

Bioresource Technology 4.980

Biochemical Journal 4.9

Apoptosis 4.788

Journal of Biological Chemistry 4.773

List of instruments Scintillation counters

Geiger Muller (GM) Counter

Storage Boxes, Waste Bins

ROCKING PLATFORM, Make [NEO LAB]

WATER BATH: Make [NEO LAB]

Electrophoresis (horizontal/Vertical) Blot Units

Radioactive Work station

Incubator-Shaker

Gel Dryer

Dry bath

Pipettes sets

Radioactive shields

etc

Radioactive Facility-School of Life Sciences

Radioactive Counting Room

Radioactive Counters

Interactions with Industry:

Indian Immunologicals

Dr Reddy’s Research Labs

Natco Pharma

Shantha Biotech

Dabur Research Foundation

NFCL

Onconova Therapeutics

Surya Pharmaceuticals

Leila Impex

Sree Biotech Pvt Ltd

Krishna Agro Pvt Ltd

Biological E Ltd.

Biosin, ABL Biotechnologies, Atul Ltd.,

Unique Biotech etc.

European Union Sponsored Nano3Bio

Final Dissemination meeting

Venue: Savitribai phule auditorium

Organized by Department of Plant SciencesFor more

details:

8th International Conference

“Photosynthesis and Hydrogen Energy Research for Sustainability – 2017”

October 30th to November 4th , 2017

in honour of

,

William A. Cramer,University of California

SanDiego

AS. RaghavendraSchool of Life Sciences

University of Hyderabad

GovindjeeUniversity of Illinois

at Urbana-Champaign, USA

In the last three years several International

conferences/workshops More then 10, Have been

organized in the School of Life Sciences by various

Departments in several areas of modern biology.

Each year more then 5 Distinguished International

Speakers visit And give talks in the School of Life

Sciences, not restricted to Life Sciences alone but

also interdisciplinary.

BioQuest is an annual event of the School of Life

Sciences to showcase the infrastructure, and the

ongoing teaching and research programs of the

School of Life Sciences. This also provides an

opportunity for the young scientists and faculty to

interact with the industry partners and clinicians to

explore collaborations.

BioQuest – Regular Yearly event

University of HyderabadDepartment of Biochemistry

UGC-SAP Funded

25 years of Biochemistry

Programs offered

M.Sc. Biochemistry• Intake: 26 +3

• CBCS curriculum

• Mode of admission:

– Thru’ national level written test

Ph.D. Biochemistry• Intake: variable (6-17)

• Course work; Journal and work presentations

• Mode of admission:

• Thru’ national level written test

• Selection based on interview

Involved in 5 years integrated

M.Sc. course in Systems Biology

Integrated M.Sc.-Ph.D. Biochemistry and Molecular Biology

• Intake: 6

• CBCS curriculum

• Mode of admission:

– Thru’ national level written test

– Selection based on interview

NEW

Team Biochemistry

Prof. KVA Ramaiah

Prof. MK Bhattacharyya

Prof. NBV Sepuri

Prof. K Mishra

Prof. S Banerjee

Prof. B Manavathi

Prof. G Ravi Kumar

Dr. S Mishra

Dr. M Akif

Dr. P Anil Kumar

Dr. S Padhi

Sr. Prof. N Siva Kumar

Expertise of the faculty members

Name PhD Expertise

Dr. M. Akif CDFD Structural Biologist

Dr. P. Anil Kumar NIN Biochemist

Prof. S. Banerjee CDFD Immunologist

Prof. MK Bhattacharyya TIFR Molecular Biologist

Dr. B Manavathi SKU Cancer Biologist

Prof. K Mishra CCMB Cell Biologist

Dr. S Mishra NII Bioinformatician

Dr. S. Padhi IIT (M) Enzymologist

Prof. KVA Ramaiah JNU Molecular Biologist

Dr. G Ravi Kumar IARI Developmental Biologist

Prof. NBV Sepuri UoH Biochemist and Cell Biologist

Prof. N Siva Kumar CFTRI Glycobiologist

The Faculty and the Ph.D. students of the Department have earned several National and International AwardsFellowship of the Andhra Pradesh Akademi of Sciences

Andhra Pradesh Scientist Awards and Society of Biological Chemists, India Teaching awards

ICMR, DST and DBT awards for their research Contributions

DAAD Fellowships, DAAD Sandwich Model FellowshipsAlexander von Humboldt Foundations Fellowship

DAAD Visiting Professorship (University of Bremen,Germany (March-July, 2019).

The research groups

• Genome maintenance, organization and expression

• Protein synthesis, homeostasis, structure-function correlation and engineering

• Organelle biogenesis and trafficking of macromolecules

• Intra-cellular communication, cancer biology and stem cell development

• Infectious diseases and host-pathogen interactions

• Bioinformatics and computational biology

Genome maintenance, organization

and expressionQuestions:

• Mechanism and regulation of DNA double strand break (DSB) repair pathways

• Choice between different competing DSB repair pathways

• Telomere maintenance• Organization of eukaryotic genome into sub-nuclear

compartments• Influence of nuclear architecture in genome stability

and expression• Epigenetic regulation of genome expression and gene

silencing

NAR (KM), JBC (MKB), MCB (MKB), MBoC (MKB), Mol Micro (MKB), RNA Biol (KM), Sci Rep (KM), Euk Cell (MKB, KM), PLoS ONE (MKB, KM), BMC Genomics (KM) etc.

Protein synthesis, homeostasis,

structure-function correlations and

protein engineeringQuestions:

• Regulation of initiation of protein synthesis in eukaryotes

• Molecular mechanism underlying unfolded protein response and its consequences

• Mitochondrial oxidative stress in protein homeostasis

• Solving the glycan structures of biologically relevant lectins and glycosidases

• Structural characterization of macromolecules and macromolecular complexes

• Biocatalysis and enzyme engineering for potential industrial applications

JBC (NBVS), MBoC (NBVS), BJ (NBVS), Biochemistry (NBVS), FASEB (KVAR), Apoptosis (KVAR), BBA (KVAR), ABB (KVAR), Glycobiology (NSK), Chem

Bio Chem (SKP), Bioorg Chem (SKP)

Organelle biogenesis and

trafficking of macromolecules

Questions:

• Evolution of lysosomal biogenesis pathways

• Mitochondrial biogenesis in health and disease

• Fe-S cluster biogenesis

• Mitochondrial import of cytosolic proteins and t-RNAs

• Regulation of RNA export by viral proreins

JCS (NBVS), MBoC (NBVS), BJ (NBVS), JBC (NBVS), PLoS One (NBVS), Glycobiology (NSK), FEBS letter (NSK), Mol Cell Gly Sci (NSK), Retrovirology (SB) etc.

Intra-cellular communication,

cancer biology and stem cell

development

Questions

• Molecular mechanisms of signal transduction

• Functionality of oncogenes during development of human cancer

• Molecular mechanism underlying megakaryocytopoiesis in neonates

Oncogene (BM), BJ (BM), JBC (BM), JAD (GRK), FASEB (GRK) etc.

Infectious diseases and host

pathogen interactions

Questions:• Whether DNA repair mechanisms of Plasmodium

can be targeted to curb malaria• Molecular mechanism of antigenic variation in

malaria parasites• Role of sumoylation in the virulence of Candida• Dynamics of HIV-TB co-infection• Modulation of host immune response during, HIV,

TB and HIV-TB co-infection• Modification and hijacking of host machinery

during HIV and TB infection• Structure based development of sub-unit vaccines

against TB and Leptospirosis

JBC (MKB), JBC (KM), Mol Micro (MKB), Cell Micro (SB), Sci Rep (SB), Retrovirology (SB), Anti Microb Agent Chemo (MKB), PLoS ONE (MKB, SB), JBact (SB) etc.

Bioinformatics and computational

biology

Questions:

• Computed aided drug design

• Network biology for cross-talks in cancer

• Systems biology of podocyte development

JBC(PAK), Sci. Rep (SM) etc.

Research output from the

department: 1993-2018

P u b lic a tio n s fr o m D e p a r tm e n t o f B io c h e m is tr y

Nu

mb

er o

f p

ub

lic

ati

on

s

0

5 0

1 0 0

1 5 0

1993-

1998

1999-

2004

2005-

2009

2010-

2014

2015-

2019

53 45

70

116

143

NAR (KM)

JBC (MKB)

JBC (KM)

JBC (BM)

JBC (PAK)

Cell Micro (SB)

Oncogene (BM)

JBact (SB)

FASEB (GRK)

IJBIOMAC (NSK)

JBC (NBVS)

MCB (KM)

MBoC (NBVS)

Mol Micro (MKB)

2015- 20192010- 2014

Current extramural funding

• Total number of ongoing projects: 29

• Total fund: ~Rs. 21 crores

• Individual project fund: ~Rs. 18.9 crores

• Programs (DST-FIST, UGC-SAP-DRS): Rs. 2.1 crores

• 9 New sanctions since August 2018

– KVAR (1); NSK (2); MKB (1); NBVS (1) KM(1); SB(1); BM (1); RG (1)

The students of Biochemistry:

Neighbor’s envy and owner’s pride

Consistency in the achievements

Career choice after MSc

1

2

3

4

Research

Industries

Teaching

Other

0

10

20

30

40

50

60

1 2 3 4 5 6

% S

ucc

ess

CSIR-UGC qualified students

2014-1

6

2013-1

5

2012-1

4

2011-1

3

Batche

s

2015-1

7

2016-1

8

The PhD students: achieving high

• Publishing in high impact journals

• Receiving PDF in premier institutions across the globe

• Setting up independent research programs

Department of Biotechnology and Bioinformatics

Profile

Teaching Programs

MSc (Biotechnology) - 1991

JNU – CEEB (DBT, NewDelhi)

20 students

Int-MSc-PhD (Biotechnology) - 2010

All India entrance exam & Interview

6 students

MTech

(Bioinformatics)

- 2006

GATE Rank

(CCMT) - AICTE

23 students

(Biology & Non-biology)

PhD

(Biotechnology) -

2008

All India entrance

exam & Interview

Interdisciplinary Research Profile of the Department

clinical

studies

Name of

Faculty

Designation PhD

+Int

(workin

g)

Publica-

tions

(2019)

IF

(Cum

Mean

)

Citation

(overall)

(2014-19)

H-

index

(2014-

2019)

i10

(2014

-19)

Patent

s

filed/g

ranted

Anand K.

Kondapi

Senior

Professor

25 (7+1) 86 (8) 3.29 1899

(1078)27 (19)

44(36

)13

P. Prakash

Babu

Senior

Professor

15(09+1

)

91 (16) 3.8 1982

(1300)23 (16)

43

(28)--

Niyaz Ahmed Professor

(On leave)

10+1

(6+1)

36 4.46 4733(264

3)40 (29)

103(8

2)1

K. P. M. S. V.

Padmasree

Professor &

Head

6(5 +1) 54 (1) 3.06 1430 (665)

19(16)26(19)

---

J. S. S. Prakash Professor 7 (8+2) 32 (3) 3.90928 (414) 17 (13)

20(16

)--

M.

Venkataraman

a

Asst

Professor

1(4+2) 4 2.5

101 -- -- 1

Vaibhav Vindal Asst

Professor

3(4) 23 (4) 2.80198 (110) 8 (7) 6 (2) --

N. Prakash

Prabhu

Asst

Professor

3 (4+1) 31 (3) 2.65336(211) 10(7) 10(6) --

Sunanda Asst 4 (3+1) 22 (2) 3.998210 (168) 8(8) 8(6) --

Faculty Profile

Total = 445 Total = 17Total = 13534 (7768)

Highlights of Department Output

Year No of Publications

2014 27

2015 28

2016 45

2017 21

2018 (Aug) 19

2019 (Aug) 46

Total 186 (30)

Patents 17

Citations 13543

Average Impact Factor

3.69

No of DatabasesPublished

6

Publications from 2013-2017 in proportion of IF

Col 1: 14.7000

Col 1: 15.4000

Col 1: 29.4000

Col 1: 29.4000

Col 1: 7.7000

Col 1: 0.7000

Col 1: 2.1000

Col 1: 0.7000

1

2

3

45

1040

Extramural Funding

Abroad: DFG, Germany – 3.5 million euro

From India:

Agency Total

Amount

(Rs.,

lacs)

DBT 934

DST 492

CSIR 125

ICMR 160

UGC 22

Consultan

cy

25

UPE 52

Total 1810

Faculty Achievements

Member, RCGM; Member, IDB Tech comm., DBT; Member, SAC, NIN - Anand K.

Kondapi

2019 — Chairman, NAAC committee for BGPS' Mumbai College of Arts, Commerce and

Science, Mumbai

2019 — UGC nominee for the SDS College of Arts and Applied Sciences Board,

Vizianagaram, Andhra Pradesh.

2018 — 2020 Member, Institutional Biosafety Committee, Biologics, Dr. Reddy’s Laboratories

Ltd - P. Prakash Babu

Santi Swarup Bhatnagar Prize 2016 National Bioscience Award of India (2012); Elected to the National Academy of Sciences, India (2002); Editor-in-Chief, Gut Pathogens, Biomed Central, London, UK

(2008 - till date); Section Editor (Genomics and Microbiology), PLoS ONE, Public Library of Science, USA (2008 - till date) - Niyaz Ahmed

Fellow, Telangana Academy of Sciences (2019); Coordinator – DST-SEC-LS-WOSA (2018);

Organizing Secretary – ICIPBI-2017; SARC Excellence in Teaching Award : SARC, India

(2011); Associate Fellow, Andhra Pradesh Akademi of Sciences, India (2011); Cullan

Devarajan Memorial Award, Society for Applied Biotechnology; Alexander von Humboldt

Visiting Fellow (2005-2007); R.D. Asana Gold Medal – Plant Physiology- Photosynthesis –

Indian Society for Plant Physiology (2001) -

- KPMSV Padmasree

Japan Society for Promotion of Science (JSPS) Award (2002-2004) - JSS Prakash

Indian Council of Medical Research Award (2010) (Conferred in Sep 2013)

Indo-US Raman Fellowship (2013-14); Associate Editor, Gut Pathogens, Biomed Central,

ICMR International Fellowship for Young Bio-medical Scientists (2018-19) by ICMR, New

Delhi.

Awarded the DAAD sponsored NAMASTE+ Fellowship to visit Goettingen University, Germany

as a Guest Professor for a period of one-month

Dr. Madhubabu G.B.

Department’s Major Collaborations

Intra-University

School of Chemistry, Physics

School of Medical sciences & Centre for Neural and Cognitive sciences

School of Mathematics, Computer and Information Sciences

Centre for Nanotechnology, High energy materials

Other Institutions

Centre of DNA fingerprinting and Diagnosis

Centre for Cellular and Molecular Biology

National Institute of Nutrition, LV Prasad Eye Institute

IIT, Hyderabad; IIIT, Hyderabad, NIPER Hyderabad

ICRISAT, Hyderabad

Industries and Hospitals

Dr. Reddy’s Research Foundation, Hetero Drugs, Vlife, Aizant, Arabindo Research Centre

(Teaching & Research)

List of Publications from Feb :

• Venkanna Bhanothu, Anand Kumar Kondapi Status of

topoisomerase‐2β protein in all‐trans retinoic acid–treated human

neuroblastoma (SK‐N‐SH) cells, Journal of cellular biochemistry,

120 (4), 5169-5182 (April 2019)

• Lavanya Madugulla, Anandha Rao Ravula, Anand Kumar

Kondapi, Suresh Yenugu, Evaluation of the reproductive toxicity

of antiretroviral drug loaded lactoferrin nanoparticles Systems

biology in reproductive medicine 65(3), 205-213 (April 2019)

• Thechano Merry, Prabhakar Maddela, Kiran Devaraya, Anand K

Kondapi, Chullikkattil P Pradeep Et3N‐Prompted Efficient

Synthesis of Anthracenyl Pyrazolines and Their Cytotoxicity

Evaluation against Cancer Cell Lines, Journal of Heterocyclic

Chemistry (2019, In Press)

Anand K. Kondapi , Senior Professor

Molecular Therapeutics, Molecular Biology of HIV, Neuronal Senescence and Brain aging

PROF. PRAKASH BABU PHANITHISENIOR PROFESSOR AND DEAN, SCHOOL OF MEDICAL SCIENCES

PUBLICATIONS - 2019

MEMBER OF COMMITTEES - SELECT

▸Chairman, Institutional Committee for Stem Cell Research, Asian Institute of Gastroenterology

▸Member, Local Research Advisory Committee, Nizam Institute of Medical Sciences (NIMS)

▸Member of IBSC, Biologics, Dr. Reddy’s,

▸Research Adviser, Narayana Medical College, Nellore (2018- )

▸Member, Institutional commit tee for stem cell research, L.V.Prasad Eye Institute, Hyderabad

ON GOING PROJECTS

▸DST- CSRI (PI-1), DBT (2, one PI, one co-PI), DST-SERB (PI-1)

GLIOMA

CEREBRAL

ISCHEMIA

STEM CELL

THERAPY

SPINAL CORD

INJURY

EPILEPSY

CEREBRAL

MALARIA

NEUROINFLAMMATION

MENINGIOMA

▸Kiran Kumar C.K, Ravindra Pramod Deshpande, Chandrasekhar Y.B.V.K, Satish Rao.I, Manas Panigrahi,

Phanithi Prakash Babu (2019). Clinical management and prognostic outcome of intracranial

ventricular tumors: A study of 134 cases, Cancer Research (in press)

▸Parimala Narne, Vimal Pande, Phanithi Prakash Babu. (2019). Role of nitric oxide and hydrogen sulfide

in ischemic stroke and the emergent epigenetic underpinnings. Mol. Neurobiol, 56: 1749-1769.

▸Vimal Pandey, Nikhil Ranjan, Parimala Narne and Phanithi Prakash Babu (2019). Roscovitine effectively

enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy

and Caspase-3 dependent apoptosis. Scientific Reports, 9:5012 |

▸Pramod Deshpande, Chandrasekhar Y.B.V.K., Deepak Babu, Satish Rao, Manas Panigrahi, Phanithi

Prakash Babu (2019) Brainstem glioma: Clinical significance and pr ognostic evaluation. Interdiscip

Neurosurg (16) 64-66; https:/ /doi.org/10.1016/ j.inat.2019.01.007

Niyaz Ahmed

• Molecular epidemiology and pathogenomics of infectious diseases including bacterial adaptation and evolution of survival mechanisms.

• Host-pathogen epidemiology of bacterial pathogens such as TB

bacilli and Helicobacters.

• Unraveling the population genetic structure and virulence

mechanisms of major human pathogens: H. pylori, M. tuberculosis,

E. coli and S. enterica.

• Molecular basis of survival of pathogens in single patients and in

host communities with varied genetic backgrounds.

On Leave:

Currently at International Centre for Diarrhoeal Disease

Research Bangladesh (icddr,b), Mohakhali, Dhaka

Plant Biochemistry & Biotechnology Lab

1. Role of Alternative Oxidase pathway of Mitochondrial Electron Transport

Chain in sustaining Photosynthesis during abiotic stress [High Light,

Osmotic Stress (or) Low Temperature] : Identified Significance of ROS,

Redox and Antioxidants using metabolomic and transcriptomic approachesSelected Publications in last Five Years :

Frontiers in Plant Science (2016), FEBS Open Bio (2016),

Annals of Botany (2015); Plant Physiology and Biochemistry (2014),

2. Purification of Seed Proteinase Inhibitors : Their Structural and

Functional Characterization for

(a) exploitation as Biopesticides (b) pharmacological agents in health

and diseaseSelected Publications in last Five Years

Phytochemistry (2010, 2018, 2019) Frontiers in Physiology (2016),

Acta Physiologia Plantarum (2015) Plant Physiology & Biochemistry (2014)

3. Preparation, Characterization and Exploitation of lignin nanoparticles as a matrix in controlled

release of agrochemicals

Selected Publications in last Five YearsEnvironmental Sci & Pollution Res. (2016), J. Exp. Nanoscience (2016), Ind. J. Exp. Biol. (2016)

Dr. K. P. M. S. V. Padmasree, Ph.DProfessor & Head

Department of Biotechnology & Bioinformatics

I. Functional genomics of cyanobacteria

3. Generated library of transcription factor & asRNA mutants

Synechocystis PCC6803

Acaryochloris marina M BIC11017

Synechococcus sp. PCC 7002

Nostoc punctiforme PCC 73102

Cyanothece PCC 7424

Anabaena variabilis ATCC 29413

M icrocystis aeruginosa NIES 843

Gloeobacter vio laceus

Thermosynechococcus elongatus

Synechococcus elongatus PCC 6301

Trichodesmium erythraeum IM S101

Prochlorococcus marinus M IT 9303

Synechococcus CC9311

2. Identified putative transcrition factors & Anti-senseRNAs

25

RNA cleavage

Heat -induced PCD

Heat-induced change in

Sll1130 conformation

ssl2245

Optimum growth

temperatureHigh temperature(A) (B)

sll1130ssl2245 sll1130

Gene 16s rDNA

Translation

Translation

Transcription

Translation

Transcription

Association

Only partial association

with Ssl2245

Figure 10: Schematic representation of heat induced programmed cell death mediated by

MazE and MazF. (A) ssl2245 and sll1130 genes constitute a dicistronic operon and are co-

transcribed. The Ssl2245 and Sll1130 form a complex under optimal growth conditions. Two

molecules of Sll1130 are associated with one molecule of Ssl2245. Sll1130 is a ribonuclease

whose function is masked by Ssl2245 under optimal growth conditions. (B) At high temperature,

Sll1130 undergoes a transition to a molten globule like form and the association between Ssl2245

and Sll1130 is significantly decreased and only a fraction of the molecules (which are in the

native state) complex with Ssl2245, while those in the molten globule state are free. Since

Sll1130 is a stable ribonuclease, the free molecules degrade 16S rRNA and several other mRNA

species. Degradation of 16SrRNA leads to inhibition of translation causing growth arrest and

eventually induces PCD of the bacterial cells. , Ssl2245; , Sll1130; , molten-globule form

of Sll1130.

Ssl2245 & Sll1130 mediate heat induced PCD in Synechocystis

JBC

C

o n

f i d

e n

t i a

l

Heat induced PCD in Synechocystis Identified mechanism of

Carbon sensing and homeostasis

Ranjith et al., doi.org/10.3389/fmicb. Front. Microbiology (2019)

Deepak et al.,doi.org/10.1002/mbo3.838 MicrobiologyOpen (2019)

Afshan et al. doi.10.1074/jbc.M116.748178, J Biol Chem, (2017)

Krishna et al., Genomics data, 6, 283-284 (2015)

Krishna et al., Biochemical Journal, 449, 751 - 760 (2013)

Sireesha et al., Biochim Biophys Acta, 1817, 1525 - 1536 (2012)

II. Genetic and metabolic engineering of cyanobacteria

1. Cyanobacterial model – Synechocystis sp. 6803

4. Have been using large scale functional genome assays to

identify regulons / regulatory networks

5. To identify the molecular mechanisms of stress response

J. S. S. Prakash, Professor - Genomics of cyanobacteria

Ongoing Research Interests:

1. Dynamics of dengue virus strain circulation in South India and

its implications in disease severity .

2. Role of dengue virus protease (N2N3&N3) in disease

manifestations.DENV Protease

Factor

‘XXX’,

cleavage

Thrombocyto

peniaMitochondrial

fragmentation

?Factor

‘YYY’

cleavage

Protein

misfolding

?

3. Identification and characterization of anti-protease

molecules (Indian Patent filing No: 201941014858)

4. Construction of infectious clone for dengue virus serotype 1

and screening of anti-protease molecules for dengue virus

infections (SERB funded)

DBT,

Funding

Dr. Musturi Venkataramana,

Assistant Professor

Vaibhav Vindal, Asst. Professor

Our lab aim to understand the key molecular players in cellular

physiology towards pathogenesis and innate immunity . In this

regard presently we are focused for two aspects

1. Computational and experimental analyses of genes encoded by

pathogen genomes: To exploit genome sequences available at public

domain and also develop tools and web resources.

2. Development of novel therapeutics and tools towards drug design:

To compile information on medicinal plant, identification of bioactive

molecule.

Latest Publication

• Bharne D, Kant P and Vindal V (2019) maGUI: A Graphical User Interface for Analysis and

Annotation of DNA Microarray Data. The Open Bioinformatics Journal, 12: 40-44, DOI:

0.2174/1875036201912010040.

• Potshangbam PA, Polavarapu R, Rathore RS, Naresh D, Prabhu NP, Potshangbam N, Kumar

P, Vindal V (2019). MedPServer: a database for identification of therapeutic targets & novel

leads pertaining to natural products. Chem Biol Drug Des. 93(4):438-446

• Naresh D, Bharne D, Saikia P, Vindal V. (2018). Anthraquinone rich Cassia fistula pod

N. Prakash Prabhu , Assistant Professor

Area of Interest: Protein Folding & Dynamics

Current Research Interests:

Effect of small orgainc molecules on protein stability and fibril formation propensity

by spectroscopic and microscopic methods

Protein stability and folding in crowded environment

Molecular simulation studies to understand the interrelation between dynamics and activity of enzymes

Recent Publications

1. Bramhini, A., Prabhu, N. P. (2019) Counteracting Effect of Charged Amino Acids Against the Destabilization of Proteins by Arginine. App. Biochem. Biotech., In Press

2. Bramhini, A., Prabhu, N. P. (2018) Glutamate induced thermal equilibrium intermediate and counteracting effect on chemical denaturation of proteins. J. Phys. Chem. B, 122 (3), 1132.

3. Haque, N., Baratam, K., Prabhu, N. P. (2018) Binding orientation and interaction of bilesalt in its ternary complex with pancreatic lipase-colipase system. Biochem. Biophys. Res.Commun. 499 (4), 907.

Posters:1. Naidu, KT., Prabhu, N. P. Effect of polyols on the thermal unfolding intermediate of

cytochrome c. 43rd Indian Biophysical Society Meeting (IBS-2019), IISER-Kolkata.

Dr. Sunanda Bhattacharyya, Assistant

Professor

Current research interest:A) Understanding the proteostasis process within the nucleus with special emphasis on identifying the role of heat shock protein 90 and its clients in various DNA-associated pathways: Grant: DBT (2013-2017), CSIR (2016-

2019)1) 2019: mSphere2) 2018: mSphere3) 2016: Molecular Biology of the Cell4) 2015: Frontiers in Oncology5) 2014: Molecular and Cellular Biology6) 2014: Eukaryotic Cell7) 2011: PLoS One

B) Functional characterization of topoisomerases in malaria parasite anddevelopment of anti-malaria compounds targeted to topoisomerases: Grant: CSIR(2012-2015), DST (2018-2021)

8) 2019: JBC9) 2017: Molecular and Biochemical Parasitology

10) 2015: mSphere11) 2015: PLoS One12) 2014: Molecular Microbiology 13) 2014: Antimicrobial Agents and Chemotherapy 14) 2013: Molecular and Biochemical Parasitology

Publications:

• Gatreddi S, Pillalamarri V, Vasudevan D, Addlagatta A, Qureshi IA (2019).

Unraveling structural insights of ribokinase from Leishmania donovani.

International Journal of Biological Macromolecules 136:253-265.

• Qureshi R, Jakkula P, Sagurthi SR, Qureshi IA (2019). Protein phosphatase

1 of Leishmania donovani exhibits conserved catalytic residues and pro-

inflammatory response. Biochemical and Biophysical Research

Communications 516:770-776.

• Goud NS, Ghouse SM, Vishnu J, Komal D, Talla V, Alvala R, Pranay J,

Kumar J, Qureshi IA, Alvala M (2019). Synthesis of 1-benzyl-1H-

benzimidazoles as galectin-1 mediated anticancer agents. Bioorganic

Chemistry 89:103016.

• Goud NS, Pooladanda V, Mahammad SG, Jakkula P, Gatreddi S, Qureshi

IA, Alvala R, Godugu C, Alvala M (2019). Synthesis and Biological

evaluation of morpholines linked coumarin-triazole hybrids as anticancer

Ahmed Qureshi

Professor, Department of Biotechnology & Bioinformatics

Life Sciences, University of Hyderabad, Hyderabad (India)

interest: Molecular and Structural Biology

Laboratory of Molecular Immunology and Infectious diseases

Dr. Nooruddin Khan, PhDAssistant Professor, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, IndiaCourtesy Assistant Professor, College of Veterinary Medicine; Cornell University, USA

Publications:

Research Interest: Molecular Immunology, Infectious diseases, vaccine and adjuvant engineering

•Khan RA, Afroz S, Minhas G, Battu S, Khan N. Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome. Cytokine. 2019 Jul 22;123:154780. doi: 10.1016/j.cyto.2019.154780. [Epub ahead of print]

•lvi SB, Appidi T, Deepak BP, Rajalakshmi PS, Minhas G, Singh SP, Begum A, Bantal V, Srivastava R, Khan N, Rengan AK. The "nano to micro" transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy. Biomater Sci. 2019 Jul 16. doi: 10.1039/c9bm00932a. [Epub ahead of print]

microbial Nano vesicle based multivalent Vaccine formulation against multiple poultry disease under DBT BIRAC

based approach to develop tetravalent vaccine against Dengue Virus by ICMR (32.5 lakhs)

talk entitled "Novel Vaccine and Adjuvant discovery platform at the " DBT-NIAID Vaccine Adjuvant Science Collaborative

April, 2019 in New Delhi.

invited talk at the Ind-CEPI Mission of Department of Biotechnology, “Epidemic preparedness through rapid vaccine developmen“

Biotechnology Industry Research Application Council (BIRAC) held on August 01, 2019 at Scope Complex, New Delhi

Mechanisms of Neurodegenerative

Diseases

1) Mechanism of Tau and Fyn mediated neurodegeneration in Alzheimer’s disease

2) Mitochondrial dynamics in aging and neurodegenerative diseases

Neurological circuits in sleep and circadian

regulation

Role and function of sleep in health and disease

Model System: Drosophila melanogaster

Dr. Madhubabu G.B., Assistant Professor

Laboratory of Neurobiology

Dr. Pankaj Singh Dholaniya

Research interest

• Application of machine learning methods for complex disease

modeling.

• Modeling gene interaction networks.

• Understanding the mechanism of neuronal senescence and age

associated neurological disorders.

• Kakade A., Kumari B., Dholaniya P.S., Feature selection

using logistic regression in case–control DNA methylation

data of Parkinson’s disease: A comparative study, Journal

of Theoretical Biology (2018),

https://doi.org/10.1016/j.jtbi.2018.08.018

Bioinformatics Data Science Group

Publication

Assistant Professor

Department of Biotechnology and Bioinformatics

School of Life Sciences, University of Hyderabad, Hyderabad

Thank you

Teaching Programs

MSc (Biotechnology) - 1991

JNU – CEEB (DBT, NewDelhi)

20 students

Int-MSc-PhD (Biotechnology) - 2010

All India entrance exam & Interview

6 students

MTech

(Bioinformatics)

- 2006

GATE Rank

(CCMT) - AICTE

23 students

(Biology & Non-biology)

PhD

(Biotechnology) -

2008

All India entrance

exam & Interview

Name of Faculty

DST DBT

UGC

CSIR ICMR

UPE

Consultancy

AnyOther (India)

Abroad(Name)

Total

AKK 60 60

PPB 123 120 --- 25 10 30 10 318

KPS 21.94

74.66

5.94

21.33

8.5 4.7 137

JSSP

MVR 52.7 52.7

VV

NPP 30 18 10 3 61 (approx)

SBT 72.28

40 44.42

8 163

IAQ 65.258

- 7.875

20.0 - 6.5 - - - 99.615

MB 40 5 45

Extra-mural Funding Mobilised from Department (2010

Regarding the student achievements:

1. Lingaswamy Bantu: (11LTPH17) is working as a

"CHEMICAL ASSISTANT" in Office of the Principal

Commissioner of Customs, Government of India, Mumbai

2. Krishna Priya (17LSMI03) is working in TCS innovation

labs as a software developer on NGS platform

3. Naina Tiwari ( ) also got the job in TCS innovation labs

and working on NGS platform. Her DoBB registration

number you may get it from office, I do not know.

4. Azaz P ( ) he is also our M.Sc., Biotechnology just

completed this year got TIGP fellowship in "Tiwan

International Graduate programme", Academia Sinica,

Taiwan.

Department of Systems & Computational Biology(DoSCB)

(http://doscb.uohyd.ac.in)

School of Life Sciences(SLS)

The Department

The Department of Systems and Computational

Biology (DoSCB) (erstwhile Virtual Centre for

Systems Biology) is the fifth department in the

School of Life Sciences. It was established as per

the statute 17(5)(a)&(b) of University of

Hyderabad based on a resolution passed by its

Executive

Council on 30th September 2018

The Faculty Members

• Prof. H. A. Nagarajaram - Professor & Head

• Dr. Vivek - Assistant Professor

• Dr. Manjari Kiran - Assistant Professor

• Dr. Sivahari Prasad Gorintla - Assistant

Professor

(UGC-FRP)

. Dr. Rakesh Pandey – INSPIRE

Faculty

Adjunct Professors

• Dr. Shekhar Mande, DG-CSIR

• Dr. Rajeev Varshney, ICRISAT

The Courses Offered• Five year Integrated Master’s course in Systems Biology (IntMSc(Syst Biol)),

being offered in conjunction with College of Integrated Studies (CIS), University

of Hyderabad

• This course encompasses an interdisciplinary approach that is developed

with changing nature of current biological research

• The students are trained in analyzing complex molecular systems and

high-throughput biological data.

• Many of the students of IntMSc(Syst Biol) are either placed in

biologicals/pharma companies or pursuing their PhDs and beyond the

University of Hyderabad or other universities and research institutes in

India and abroad.

• PhD in Systems and Computational Biology

First batch (2019) – 4

Systems Biology

Computational Biology

Bioinformatics

Genomics

DOSCB-RESEARCH

ResearchSystems biology

• Construction and analyses of spatio-temporal and context dependent (for ex: viral infection) human protein-protein interaction networks and deciphering topological roles and properties of human proteins and their interacting partners in those networks

• Drug-protein interaction networks: Topological properties of targets of approved versus withdrawn drugs

• Roles of products of HTGs in PPINs• Signalling and Regulatory Networks• Pathogenesis of Inflammatory skin diseases,

Psoriasis and Atopic Dermatitis• Synthetic Gene Circuits

Research (contd…)Disease Informatics & Biomarker Discovery

o Analyses of functional impacts of human missense mutations on protein structure, function and interactions

o Analyses of loss/gain of function mutations o Development of novel prediction toolso Analyses of Human Volatilome toward cancer

biomarker discovery o Identification of potential prognostic signatures for

predicting survival in cancerso non-cancer drug repositioning

Cancer Biology o Understanding the drug resistance mechanisms in leukemia models and

solid tumors against targeted therapies.

o Generation of Leukemia models

o Identification of novel therapeutic agents in Leukemia

Research (contd…)

Protein Structures and Evolution o Development of novel protein structure prediction toolso Analysis of structural variability and evolution of disordered regions

and investigating into “Structure-Disorder-Function” paradigm

Non-coding RNA Biology o Identification and characterisation of novel non-coding RNAs

Genomics & Metagenomics o Metagenome analyses of gut and root microbiota in healthy and

disease conditions and also the bacteria thriving near industrial effluent plants

o Integration of various ‘omics’ data for gene knowledge mining and genome annotation

o Neutri-genomics for important crops

Publications by the faculty members

• About 100 publications in peer-reviewed

international journals such as PNAS,

J.Proteome Res, NAR, etc

• One Indian Patent filed

Investigators:

Prof. José Sousa Câmara, PI, University of Madeira, Portugal

Prof. Schubert, Rostock Medical Centre, PI, Rostock, Germany

Dr. Srikanth Rapole, PI, NCCS, Pune, India

Prof..Nagarajaram, PI, DoSCB, UoH, Hyderabad, India

1. NCDs-CAPomics: Exploring the Volatome of

NonCommunicable Diseases as a Promising Non-

Invasive and Integrating Approach for its Rapid

Diagnostics. The Case Study of Cancer and

Neurodegenerative Diseases (2019-2022) (II Phase)

Extramural Funding

Investigators:

Prof. Bramandam Manavathi, PI, Dept. Biochemistry, SLS

Prof..Nagarajaram, Co-PI, DoSCB, UoH, Hyderabad, India

2. Nucleolus in control of breast tumor

heterogeneity

A MHRD, Government of India under

“Scheme for Translational and Advanced

Research in Sciences (STAR)”

Investigators:

Prof. Dayananda, Coordinator and PI, Dept. Animal Sciences, SLS,

UoH

Prof. Venkataramana, Co-PI, Dept. Plant Sciences, SLS, UoH

Prof. Nagarajaram, Co-PI, DoSCB, SLS, UoH

Chemical and genomic approaches to investigate possible link between

development of antimicrobial resistance (AMR) and pharma industry

effluents (2019-2021)

supported by a grant from Bulk Drug Manufacturers Association of

India (BDMAI)

Industry Funding

Fellowships

1. Ramalingaswamy Fellowship

Dr. Vivek

2. DST-INSPIRE Faculty

Dr. Rakesh Pandey

Thank You

School of Life Sciences