Office of International Affairs - Sciencesconf.org
Transcript of Office of International Affairs - Sciencesconf.org
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Office of International
Affairs
12/4/2019 1www.uohyd.ernet.in
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About the OIA
Office headed by Director, International Affairs and managed by Private Secretary to the Director.
University of Hyderabad has several MoUs with various Universities of high repute across the globe.
Some of the countries include:
USA—University of Illinois at Springfield, University of Iowa, Portland State University
Germany—University of Muenster; University of Wurzburg, Freie University
Canada—University of Alberta,
Sweden—Linnaeus University
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Ongoing and upcoming Activities:
University of Bordeaux, France (27-11-2019)
University of Saskatchewan, Saskatoon, Canada (03-12-2019)
Visit of delegation from University of Auckland, New Zealand on December 4, 2019
International Research Training Groups: University of Muenster, Freie University, Germany
Two independent New Passage to India program that facilitates exchange of Students and Faculty on both sides.
12/4/2019 3www.uohyd.ernet.in
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Australian National University (Future Research Talent Awards—10-12 week research experience in the fields of Science, Health and Medicine during May-August 2020
Australia Awards Scholarships to pursue Masters program at Australian Universities. Two students were selected to pursue Masters program at University of Melbourne. to work at Women’s Studies
Study India Program an initiative of the Ministry of Human Resource Development-admission through SII portal to study various courses/pograms.
Scheme for Promotion of Academic and Research Collaboration (SPARC)—specific research projects with international universities that have QS rankings below 500. University of Hyderabad has been identified as Nodal Institute for Brazil.
DUO-INDIA program for Faculty and Student Exchange between UoH and 14 countries in Europe
Activities
12/4/2019 4www.uohyd.ernet.in
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Some statistics about International Students pursuing various courses:
At any given point of time 50 international students (both Masters and Ph.D.) are enrolled at the University. The students come from—Afghanistan, Bangladesh, Ghana, Guyana, Ethiopia, Iran, Thailand, Syria, South Africa, Yemen, USA
International Students
12/4/2019 5www.uohyd.ernet.in
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School of Life SciencesUniversity of Hyderabad
(Website: sls.uohyd.ac.in)
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School of Life Sciences (1977)
Dept of Animal
Biology
Dept of
Biochemistry
M. Sc. Biotechnology
M.Tech. Bioinformatics
Int. PhD & Ph D in Biotechnology
UGC Special Assistance,
COSIST,DRS; DST- FIST
Dept of
Biotechnologysince 2008
Depts since 1993
Multidisciplinary, with several courses and
intense research activities
M. Sc. Biochemistry
Ph. D. Biochemistry
Dept of Plant
Sciences
M. Sc. Plant Biology &
Biotechnology
M.Sc Molecular
Microbiology
Ph. D. Plant Science
Workshops & Refresher Courses
M. Sc. Animal Biology &
Biotechnology
Ph. D. Animal Science
Center for Systems
Biology
5yr IMSc in
Systems Biology
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Infrastructural Facilities
❖Genomics, proteomics, metabolomics, live celland live animal imaging facility, confocalmicroscope, SEM & TEM, High endcomputational facilities, etc.
❖Radiation Facility
❖Biosafety level-3 facility for small animals and reasonably well established animal house
❖Green House Facilities
❖Seminar hall with 200 seating and auditorium with 600 seating.
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Training Workshops: Proteomics and Genomics,
including Microarraysfor Ph. D. Students & Post-docs from UoH as well as outside
Expenditure for infrastructure and recurring expenses were
met from the grants of SAP-CAS & DBT-CREBB
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Workshops & Training Programs
❖Global Initiative of Academic Networks (GIAN)
workshops involving industry representatives• Cancer Drug Discovery and Development;
• Immunologicals in Animal and Human Health;
• Ion Channels in Human Diseases;
• Lipid Signaling in Health and Disease in Animals and Plants;
• Stem Cells and Regenerative Medicine
• Protein Structure and Drug Discovery
• Glycoconjugates-Role in Biology and Biomedical Relevance
• Total of 10 GIAN Programs have been conducted and some more are
under active consideration.
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Indian Immunologicals
Dr Reddy’s Research Labs
Natco Pharma
Shantha Biotech
Dabur Research Foundation
Aurobindo Pharma
Atul Ltd.
Nagarjuna Fertilisers and Chemicals Ltd. (NFCL)
Onconova Therapeutics
Laila Impex
Sree Biotech Pvt Ltd
Krishna Agro Pvt Ltd
Biological E Ltd.
Biosin, Unique Biotech Ltd.
Interactions with Industry
Bulk Drugs manufacturing Association
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Biosafety Level-3 (BSL-3)
FACILITY
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BIRAC Sponsored BioNEST
(Bioincubators Nurturing Entrepreneurship for scaling Technologies)
❖ Objectives
❖To foster entrepreneurship initiatives in the area of
biotechnology at University of Hyderabad (UoH).
❖Creation of state-of-art infrastructure and intellectual
resources, IPR and entrepreneurship environment for
budding entrepreneurs.
❖ Key Goals
❖To tap innovations & ideas
❖Converting ideas/innovations to prototypes
❖Scaling of prototypes to marketable products
❖The proposed UoH-BioNEST will focus on new as well
as emerging technologies, multidisciplinary and
translational research in the areas of Biology and
Biotechnology
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Publications in High Impact Factor JournalsNature 42.35
Science 34.66
Nature Reviews Microbiology 21.182
Progress in Lipid Research 14.23
Trends in Plant Sciences 11.047
Trends in Biotechnology
Seminars in Cancer biology
9.148
9.955
Nucleic Acid Research 9.11
Critical Reviews in Biochemistry & Molecular Biology 7.655
Plant Physiology 7.054
Critical Reviews in Biotechnology 6.472
Oncogene 6.373
Critical Reviews in Microbiology 6.270
Molecular Biology of the Cell 5.98
The FASEB Journal 5.712
Scientific Reports 5.6
Journal of Lipid Research 5.559
Journal of Experimental Botany 5.364
Plant, Cell & Environment 5.215
Biochimica et Biophysica Acta 5.000
Bioresource Technology 4.980
Biochemical Journal 4.9
Apoptosis 4.788
Journal of Biological Chemistry 4.773
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List of instruments Scintillation counters
Geiger Muller (GM) Counter
Storage Boxes, Waste Bins
ROCKING PLATFORM, Make [NEO LAB]
WATER BATH: Make [NEO LAB]
Electrophoresis (horizontal/Vertical) Blot Units
Radioactive Work station
Incubator-Shaker
Gel Dryer
Dry bath
Pipettes sets
Radioactive shields
etc
Radioactive Facility-School of Life Sciences
Radioactive Counting Room
Radioactive Counters
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Interactions with Industry:
Indian Immunologicals
Dr Reddy’s Research Labs
Natco Pharma
Shantha Biotech
Dabur Research Foundation
NFCL
Onconova Therapeutics
Surya Pharmaceuticals
Leila Impex
Sree Biotech Pvt Ltd
Krishna Agro Pvt Ltd
Biological E Ltd.
Biosin, ABL Biotechnologies, Atul Ltd.,
Unique Biotech etc.
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European Union Sponsored Nano3Bio
Final Dissemination meeting
Venue: Savitribai phule auditorium
Organized by Department of Plant SciencesFor more
details:
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8th International Conference
“Photosynthesis and Hydrogen Energy Research for Sustainability – 2017”
October 30th to November 4th , 2017
in honour of
,
William A. Cramer,University of California
SanDiego
AS. RaghavendraSchool of Life Sciences
University of Hyderabad
GovindjeeUniversity of Illinois
at Urbana-Champaign, USA
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In the last three years several International
conferences/workshops More then 10, Have been
organized in the School of Life Sciences by various
Departments in several areas of modern biology.
Each year more then 5 Distinguished International
Speakers visit And give talks in the School of Life
Sciences, not restricted to Life Sciences alone but
also interdisciplinary.
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BioQuest is an annual event of the School of Life
Sciences to showcase the infrastructure, and the
ongoing teaching and research programs of the
School of Life Sciences. This also provides an
opportunity for the young scientists and faculty to
interact with the industry partners and clinicians to
explore collaborations.
BioQuest – Regular Yearly event
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University of HyderabadDepartment of Biochemistry
UGC-SAP Funded
25 years of Biochemistry
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Programs offered
M.Sc. Biochemistry• Intake: 26 +3
• CBCS curriculum
• Mode of admission:
– Thru’ national level written test
Ph.D. Biochemistry• Intake: variable (6-17)
• Course work; Journal and work presentations
• Mode of admission:
• Thru’ national level written test
• Selection based on interview
Involved in 5 years integrated
M.Sc. course in Systems Biology
Integrated M.Sc.-Ph.D. Biochemistry and Molecular Biology
• Intake: 6
• CBCS curriculum
• Mode of admission:
– Thru’ national level written test
– Selection based on interview
NEW
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Team Biochemistry
Prof. KVA Ramaiah
Prof. MK Bhattacharyya
Prof. NBV Sepuri
Prof. K Mishra
Prof. S Banerjee
Prof. B Manavathi
Prof. G Ravi Kumar
Dr. S Mishra
Dr. M Akif
Dr. P Anil Kumar
Dr. S Padhi
Sr. Prof. N Siva Kumar
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Expertise of the faculty members
Name PhD Expertise
Dr. M. Akif CDFD Structural Biologist
Dr. P. Anil Kumar NIN Biochemist
Prof. S. Banerjee CDFD Immunologist
Prof. MK Bhattacharyya TIFR Molecular Biologist
Dr. B Manavathi SKU Cancer Biologist
Prof. K Mishra CCMB Cell Biologist
Dr. S Mishra NII Bioinformatician
Dr. S. Padhi IIT (M) Enzymologist
Prof. KVA Ramaiah JNU Molecular Biologist
Dr. G Ravi Kumar IARI Developmental Biologist
Prof. NBV Sepuri UoH Biochemist and Cell Biologist
Prof. N Siva Kumar CFTRI Glycobiologist
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The Faculty and the Ph.D. students of the Department have earned several National and International AwardsFellowship of the Andhra Pradesh Akademi of Sciences
Andhra Pradesh Scientist Awards and Society of Biological Chemists, India Teaching awards
ICMR, DST and DBT awards for their research Contributions
DAAD Fellowships, DAAD Sandwich Model FellowshipsAlexander von Humboldt Foundations Fellowship
DAAD Visiting Professorship (University of Bremen,Germany (March-July, 2019).
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The research groups
• Genome maintenance, organization and expression
• Protein synthesis, homeostasis, structure-function correlation and engineering
• Organelle biogenesis and trafficking of macromolecules
• Intra-cellular communication, cancer biology and stem cell development
• Infectious diseases and host-pathogen interactions
• Bioinformatics and computational biology
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Genome maintenance, organization
and expressionQuestions:
• Mechanism and regulation of DNA double strand break (DSB) repair pathways
• Choice between different competing DSB repair pathways
• Telomere maintenance• Organization of eukaryotic genome into sub-nuclear
compartments• Influence of nuclear architecture in genome stability
and expression• Epigenetic regulation of genome expression and gene
silencing
NAR (KM), JBC (MKB), MCB (MKB), MBoC (MKB), Mol Micro (MKB), RNA Biol (KM), Sci Rep (KM), Euk Cell (MKB, KM), PLoS ONE (MKB, KM), BMC Genomics (KM) etc.
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Protein synthesis, homeostasis,
structure-function correlations and
protein engineeringQuestions:
• Regulation of initiation of protein synthesis in eukaryotes
• Molecular mechanism underlying unfolded protein response and its consequences
• Mitochondrial oxidative stress in protein homeostasis
• Solving the glycan structures of biologically relevant lectins and glycosidases
• Structural characterization of macromolecules and macromolecular complexes
• Biocatalysis and enzyme engineering for potential industrial applications
JBC (NBVS), MBoC (NBVS), BJ (NBVS), Biochemistry (NBVS), FASEB (KVAR), Apoptosis (KVAR), BBA (KVAR), ABB (KVAR), Glycobiology (NSK), Chem
Bio Chem (SKP), Bioorg Chem (SKP)
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Organelle biogenesis and
trafficking of macromolecules
Questions:
• Evolution of lysosomal biogenesis pathways
• Mitochondrial biogenesis in health and disease
• Fe-S cluster biogenesis
• Mitochondrial import of cytosolic proteins and t-RNAs
• Regulation of RNA export by viral proreins
JCS (NBVS), MBoC (NBVS), BJ (NBVS), JBC (NBVS), PLoS One (NBVS), Glycobiology (NSK), FEBS letter (NSK), Mol Cell Gly Sci (NSK), Retrovirology (SB) etc.
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Intra-cellular communication,
cancer biology and stem cell
development
Questions
• Molecular mechanisms of signal transduction
• Functionality of oncogenes during development of human cancer
• Molecular mechanism underlying megakaryocytopoiesis in neonates
Oncogene (BM), BJ (BM), JBC (BM), JAD (GRK), FASEB (GRK) etc.
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Infectious diseases and host
pathogen interactions
Questions:• Whether DNA repair mechanisms of Plasmodium
can be targeted to curb malaria• Molecular mechanism of antigenic variation in
malaria parasites• Role of sumoylation in the virulence of Candida• Dynamics of HIV-TB co-infection• Modulation of host immune response during, HIV,
TB and HIV-TB co-infection• Modification and hijacking of host machinery
during HIV and TB infection• Structure based development of sub-unit vaccines
against TB and Leptospirosis
JBC (MKB), JBC (KM), Mol Micro (MKB), Cell Micro (SB), Sci Rep (SB), Retrovirology (SB), Anti Microb Agent Chemo (MKB), PLoS ONE (MKB, SB), JBact (SB) etc.
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Bioinformatics and computational
biology
Questions:
• Computed aided drug design
• Network biology for cross-talks in cancer
• Systems biology of podocyte development
JBC(PAK), Sci. Rep (SM) etc.
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Research output from the
department: 1993-2018
P u b lic a tio n s fr o m D e p a r tm e n t o f B io c h e m is tr y
Nu
mb
er o
f p
ub
lic
ati
on
s
0
5 0
1 0 0
1 5 0
1993-
1998
1999-
2004
2005-
2009
2010-
2014
2015-
2019
53 45
70
116
143
NAR (KM)
JBC (MKB)
JBC (KM)
JBC (BM)
JBC (PAK)
Cell Micro (SB)
Oncogene (BM)
JBact (SB)
FASEB (GRK)
IJBIOMAC (NSK)
JBC (NBVS)
MCB (KM)
MBoC (NBVS)
Mol Micro (MKB)
2015- 20192010- 2014
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Current extramural funding
• Total number of ongoing projects: 29
• Total fund: ~Rs. 21 crores
• Individual project fund: ~Rs. 18.9 crores
• Programs (DST-FIST, UGC-SAP-DRS): Rs. 2.1 crores
• 9 New sanctions since August 2018
– KVAR (1); NSK (2); MKB (1); NBVS (1) KM(1); SB(1); BM (1); RG (1)
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The students of Biochemistry:
Neighbor’s envy and owner’s pride
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Consistency in the achievements
Career choice after MSc
1
2
3
4
Research
Industries
Teaching
Other
0
10
20
30
40
50
60
1 2 3 4 5 6
% S
ucc
ess
CSIR-UGC qualified students
2014-1
6
2013-1
5
2012-1
4
2011-1
3
Batche
s
2015-1
7
2016-1
8
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The PhD students: achieving high
• Publishing in high impact journals
• Receiving PDF in premier institutions across the globe
• Setting up independent research programs
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Department of Biotechnology and Bioinformatics
Profile
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Teaching Programs
MSc (Biotechnology) - 1991
JNU – CEEB (DBT, NewDelhi)
20 students
Int-MSc-PhD (Biotechnology) - 2010
All India entrance exam & Interview
6 students
MTech
(Bioinformatics)
- 2006
GATE Rank
(CCMT) - AICTE
23 students
(Biology & Non-biology)
PhD
(Biotechnology) -
2008
All India entrance
exam & Interview
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Interdisciplinary Research Profile of the Department
clinical
studies
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Name of
Faculty
Designation PhD
+Int
(workin
g)
Publica-
tions
(2019)
IF
(Cum
Mean
)
Citation
(overall)
(2014-19)
H-
index
(2014-
2019)
i10
(2014
-19)
Patent
s
filed/g
ranted
Anand K.
Kondapi
Senior
Professor
25 (7+1) 86 (8) 3.29 1899
(1078)27 (19)
44(36
)13
P. Prakash
Babu
Senior
Professor
15(09+1
)
91 (16) 3.8 1982
(1300)23 (16)
43
(28)--
Niyaz Ahmed Professor
(On leave)
10+1
(6+1)
36 4.46 4733(264
3)40 (29)
103(8
2)1
K. P. M. S. V.
Padmasree
Professor &
Head
6(5 +1) 54 (1) 3.06 1430 (665)
19(16)26(19)
---
J. S. S. Prakash Professor 7 (8+2) 32 (3) 3.90928 (414) 17 (13)
20(16
)--
M.
Venkataraman
a
Asst
Professor
1(4+2) 4 2.5
101 -- -- 1
Vaibhav Vindal Asst
Professor
3(4) 23 (4) 2.80198 (110) 8 (7) 6 (2) --
N. Prakash
Prabhu
Asst
Professor
3 (4+1) 31 (3) 2.65336(211) 10(7) 10(6) --
Sunanda Asst 4 (3+1) 22 (2) 3.998210 (168) 8(8) 8(6) --
Faculty Profile
Total = 445 Total = 17Total = 13534 (7768)
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Highlights of Department Output
Year No of Publications
2014 27
2015 28
2016 45
2017 21
2018 (Aug) 19
2019 (Aug) 46
Total 186 (30)
Patents 17
Citations 13543
Average Impact Factor
3.69
No of DatabasesPublished
6
Publications from 2013-2017 in proportion of IF
Col 1: 14.7000
Col 1: 15.4000
Col 1: 29.4000
Col 1: 29.4000
Col 1: 7.7000
Col 1: 0.7000
Col 1: 2.1000
Col 1: 0.7000
1
2
3
45
1040
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Extramural Funding
Abroad: DFG, Germany – 3.5 million euro
From India:
Agency Total
Amount
(Rs.,
lacs)
DBT 934
DST 492
CSIR 125
ICMR 160
UGC 22
Consultan
cy
25
UPE 52
Total 1810
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Faculty Achievements
Member, RCGM; Member, IDB Tech comm., DBT; Member, SAC, NIN - Anand K.
Kondapi
2019 — Chairman, NAAC committee for BGPS' Mumbai College of Arts, Commerce and
Science, Mumbai
2019 — UGC nominee for the SDS College of Arts and Applied Sciences Board,
Vizianagaram, Andhra Pradesh.
2018 — 2020 Member, Institutional Biosafety Committee, Biologics, Dr. Reddy’s Laboratories
Ltd - P. Prakash Babu
Santi Swarup Bhatnagar Prize 2016 National Bioscience Award of India (2012); Elected to the National Academy of Sciences, India (2002); Editor-in-Chief, Gut Pathogens, Biomed Central, London, UK
(2008 - till date); Section Editor (Genomics and Microbiology), PLoS ONE, Public Library of Science, USA (2008 - till date) - Niyaz Ahmed
Fellow, Telangana Academy of Sciences (2019); Coordinator – DST-SEC-LS-WOSA (2018);
Organizing Secretary – ICIPBI-2017; SARC Excellence in Teaching Award : SARC, India
(2011); Associate Fellow, Andhra Pradesh Akademi of Sciences, India (2011); Cullan
Devarajan Memorial Award, Society for Applied Biotechnology; Alexander von Humboldt
Visiting Fellow (2005-2007); R.D. Asana Gold Medal – Plant Physiology- Photosynthesis –
Indian Society for Plant Physiology (2001) -
- KPMSV Padmasree
Japan Society for Promotion of Science (JSPS) Award (2002-2004) - JSS Prakash
Indian Council of Medical Research Award (2010) (Conferred in Sep 2013)
Indo-US Raman Fellowship (2013-14); Associate Editor, Gut Pathogens, Biomed Central,
ICMR International Fellowship for Young Bio-medical Scientists (2018-19) by ICMR, New
Delhi.
Awarded the DAAD sponsored NAMASTE+ Fellowship to visit Goettingen University, Germany
as a Guest Professor for a period of one-month
Dr. Madhubabu G.B.
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Department’s Major Collaborations
Intra-University
School of Chemistry, Physics
School of Medical sciences & Centre for Neural and Cognitive sciences
School of Mathematics, Computer and Information Sciences
Centre for Nanotechnology, High energy materials
Other Institutions
Centre of DNA fingerprinting and Diagnosis
Centre for Cellular and Molecular Biology
National Institute of Nutrition, LV Prasad Eye Institute
IIT, Hyderabad; IIIT, Hyderabad, NIPER Hyderabad
ICRISAT, Hyderabad
Industries and Hospitals
Dr. Reddy’s Research Foundation, Hetero Drugs, Vlife, Aizant, Arabindo Research Centre
(Teaching & Research)
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List of Publications from Feb :
• Venkanna Bhanothu, Anand Kumar Kondapi Status of
topoisomerase‐2β protein in all‐trans retinoic acid–treated human
neuroblastoma (SK‐N‐SH) cells, Journal of cellular biochemistry,
120 (4), 5169-5182 (April 2019)
• Lavanya Madugulla, Anandha Rao Ravula, Anand Kumar
Kondapi, Suresh Yenugu, Evaluation of the reproductive toxicity
of antiretroviral drug loaded lactoferrin nanoparticles Systems
biology in reproductive medicine 65(3), 205-213 (April 2019)
• Thechano Merry, Prabhakar Maddela, Kiran Devaraya, Anand K
Kondapi, Chullikkattil P Pradeep Et3N‐Prompted Efficient
Synthesis of Anthracenyl Pyrazolines and Their Cytotoxicity
Evaluation against Cancer Cell Lines, Journal of Heterocyclic
Chemistry (2019, In Press)
Anand K. Kondapi , Senior Professor
Molecular Therapeutics, Molecular Biology of HIV, Neuronal Senescence and Brain aging
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PROF. PRAKASH BABU PHANITHISENIOR PROFESSOR AND DEAN, SCHOOL OF MEDICAL SCIENCES
PUBLICATIONS - 2019
MEMBER OF COMMITTEES - SELECT
▸Chairman, Institutional Committee for Stem Cell Research, Asian Institute of Gastroenterology
▸Member, Local Research Advisory Committee, Nizam Institute of Medical Sciences (NIMS)
▸Member of IBSC, Biologics, Dr. Reddy’s,
▸Research Adviser, Narayana Medical College, Nellore (2018- )
▸Member, Institutional commit tee for stem cell research, L.V.Prasad Eye Institute, Hyderabad
ON GOING PROJECTS
▸DST- CSRI (PI-1), DBT (2, one PI, one co-PI), DST-SERB (PI-1)
GLIOMA
CEREBRAL
ISCHEMIA
STEM CELL
THERAPY
SPINAL CORD
INJURY
EPILEPSY
CEREBRAL
MALARIA
NEUROINFLAMMATION
MENINGIOMA
▸Kiran Kumar C.K, Ravindra Pramod Deshpande, Chandrasekhar Y.B.V.K, Satish Rao.I, Manas Panigrahi,
Phanithi Prakash Babu (2019). Clinical management and prognostic outcome of intracranial
ventricular tumors: A study of 134 cases, Cancer Research (in press)
▸Parimala Narne, Vimal Pande, Phanithi Prakash Babu. (2019). Role of nitric oxide and hydrogen sulfide
in ischemic stroke and the emergent epigenetic underpinnings. Mol. Neurobiol, 56: 1749-1769.
▸Vimal Pandey, Nikhil Ranjan, Parimala Narne and Phanithi Prakash Babu (2019). Roscovitine effectively
enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy
and Caspase-3 dependent apoptosis. Scientific Reports, 9:5012 |
▸Pramod Deshpande, Chandrasekhar Y.B.V.K., Deepak Babu, Satish Rao, Manas Panigrahi, Phanithi
Prakash Babu (2019) Brainstem glioma: Clinical significance and pr ognostic evaluation. Interdiscip
Neurosurg (16) 64-66; https:/ /doi.org/10.1016/ j.inat.2019.01.007
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Niyaz Ahmed
• Molecular epidemiology and pathogenomics of infectious diseases including bacterial adaptation and evolution of survival mechanisms.
• Host-pathogen epidemiology of bacterial pathogens such as TB
bacilli and Helicobacters.
• Unraveling the population genetic structure and virulence
mechanisms of major human pathogens: H. pylori, M. tuberculosis,
E. coli and S. enterica.
• Molecular basis of survival of pathogens in single patients and in
host communities with varied genetic backgrounds.
On Leave:
Currently at International Centre for Diarrhoeal Disease
Research Bangladesh (icddr,b), Mohakhali, Dhaka
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Plant Biochemistry & Biotechnology Lab
1. Role of Alternative Oxidase pathway of Mitochondrial Electron Transport
Chain in sustaining Photosynthesis during abiotic stress [High Light,
Osmotic Stress (or) Low Temperature] : Identified Significance of ROS,
Redox and Antioxidants using metabolomic and transcriptomic approachesSelected Publications in last Five Years :
Frontiers in Plant Science (2016), FEBS Open Bio (2016),
Annals of Botany (2015); Plant Physiology and Biochemistry (2014),
2. Purification of Seed Proteinase Inhibitors : Their Structural and
Functional Characterization for
(a) exploitation as Biopesticides (b) pharmacological agents in health
and diseaseSelected Publications in last Five Years
Phytochemistry (2010, 2018, 2019) Frontiers in Physiology (2016),
Acta Physiologia Plantarum (2015) Plant Physiology & Biochemistry (2014)
3. Preparation, Characterization and Exploitation of lignin nanoparticles as a matrix in controlled
release of agrochemicals
Selected Publications in last Five YearsEnvironmental Sci & Pollution Res. (2016), J. Exp. Nanoscience (2016), Ind. J. Exp. Biol. (2016)
Dr. K. P. M. S. V. Padmasree, Ph.DProfessor & Head
Department of Biotechnology & Bioinformatics
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I. Functional genomics of cyanobacteria
3. Generated library of transcription factor & asRNA mutants
Synechocystis PCC6803
Acaryochloris marina M BIC11017
Synechococcus sp. PCC 7002
Nostoc punctiforme PCC 73102
Cyanothece PCC 7424
Anabaena variabilis ATCC 29413
M icrocystis aeruginosa NIES 843
Gloeobacter vio laceus
Thermosynechococcus elongatus
Synechococcus elongatus PCC 6301
Trichodesmium erythraeum IM S101
Prochlorococcus marinus M IT 9303
Synechococcus CC9311
2. Identified putative transcrition factors & Anti-senseRNAs
25
RNA cleavage
Heat -induced PCD
Heat-induced change in
Sll1130 conformation
ssl2245
Optimum growth
temperatureHigh temperature(A) (B)
sll1130ssl2245 sll1130
Gene 16s rDNA
Translation
Translation
Transcription
Translation
Transcription
Association
Only partial association
with Ssl2245
Figure 10: Schematic representation of heat induced programmed cell death mediated by
MazE and MazF. (A) ssl2245 and sll1130 genes constitute a dicistronic operon and are co-
transcribed. The Ssl2245 and Sll1130 form a complex under optimal growth conditions. Two
molecules of Sll1130 are associated with one molecule of Ssl2245. Sll1130 is a ribonuclease
whose function is masked by Ssl2245 under optimal growth conditions. (B) At high temperature,
Sll1130 undergoes a transition to a molten globule like form and the association between Ssl2245
and Sll1130 is significantly decreased and only a fraction of the molecules (which are in the
native state) complex with Ssl2245, while those in the molten globule state are free. Since
Sll1130 is a stable ribonuclease, the free molecules degrade 16S rRNA and several other mRNA
species. Degradation of 16SrRNA leads to inhibition of translation causing growth arrest and
eventually induces PCD of the bacterial cells. , Ssl2245; , Sll1130; , molten-globule form
of Sll1130.
Ssl2245 & Sll1130 mediate heat induced PCD in Synechocystis
JBC
C
o n
f i d
e n
t i a
l
Heat induced PCD in Synechocystis Identified mechanism of
Carbon sensing and homeostasis
Ranjith et al., doi.org/10.3389/fmicb. Front. Microbiology (2019)
Deepak et al.,doi.org/10.1002/mbo3.838 MicrobiologyOpen (2019)
Afshan et al. doi.10.1074/jbc.M116.748178, J Biol Chem, (2017)
Krishna et al., Genomics data, 6, 283-284 (2015)
Krishna et al., Biochemical Journal, 449, 751 - 760 (2013)
Sireesha et al., Biochim Biophys Acta, 1817, 1525 - 1536 (2012)
II. Genetic and metabolic engineering of cyanobacteria
1. Cyanobacterial model – Synechocystis sp. 6803
4. Have been using large scale functional genome assays to
identify regulons / regulatory networks
5. To identify the molecular mechanisms of stress response
J. S. S. Prakash, Professor - Genomics of cyanobacteria
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Ongoing Research Interests:
1. Dynamics of dengue virus strain circulation in South India and
its implications in disease severity .
2. Role of dengue virus protease (N2N3&N3) in disease
manifestations.DENV Protease
Factor
‘XXX’,
cleavage
Thrombocyto
peniaMitochondrial
fragmentation
?Factor
‘YYY’
cleavage
Protein
misfolding
?
3. Identification and characterization of anti-protease
molecules (Indian Patent filing No: 201941014858)
4. Construction of infectious clone for dengue virus serotype 1
and screening of anti-protease molecules for dengue virus
infections (SERB funded)
DBT,
Funding
Dr. Musturi Venkataramana,
Assistant Professor
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Vaibhav Vindal, Asst. Professor
Our lab aim to understand the key molecular players in cellular
physiology towards pathogenesis and innate immunity . In this
regard presently we are focused for two aspects
1. Computational and experimental analyses of genes encoded by
pathogen genomes: To exploit genome sequences available at public
domain and also develop tools and web resources.
2. Development of novel therapeutics and tools towards drug design:
To compile information on medicinal plant, identification of bioactive
molecule.
Latest Publication
• Bharne D, Kant P and Vindal V (2019) maGUI: A Graphical User Interface for Analysis and
Annotation of DNA Microarray Data. The Open Bioinformatics Journal, 12: 40-44, DOI:
0.2174/1875036201912010040.
• Potshangbam PA, Polavarapu R, Rathore RS, Naresh D, Prabhu NP, Potshangbam N, Kumar
P, Vindal V (2019). MedPServer: a database for identification of therapeutic targets & novel
leads pertaining to natural products. Chem Biol Drug Des. 93(4):438-446
• Naresh D, Bharne D, Saikia P, Vindal V. (2018). Anthraquinone rich Cassia fistula pod
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N. Prakash Prabhu , Assistant Professor
Area of Interest: Protein Folding & Dynamics
Current Research Interests:
Effect of small orgainc molecules on protein stability and fibril formation propensity
by spectroscopic and microscopic methods
Protein stability and folding in crowded environment
Molecular simulation studies to understand the interrelation between dynamics and activity of enzymes
Recent Publications
1. Bramhini, A., Prabhu, N. P. (2019) Counteracting Effect of Charged Amino Acids Against the Destabilization of Proteins by Arginine. App. Biochem. Biotech., In Press
2. Bramhini, A., Prabhu, N. P. (2018) Glutamate induced thermal equilibrium intermediate and counteracting effect on chemical denaturation of proteins. J. Phys. Chem. B, 122 (3), 1132.
3. Haque, N., Baratam, K., Prabhu, N. P. (2018) Binding orientation and interaction of bilesalt in its ternary complex with pancreatic lipase-colipase system. Biochem. Biophys. Res.Commun. 499 (4), 907.
Posters:1. Naidu, KT., Prabhu, N. P. Effect of polyols on the thermal unfolding intermediate of
cytochrome c. 43rd Indian Biophysical Society Meeting (IBS-2019), IISER-Kolkata.
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Dr. Sunanda Bhattacharyya, Assistant
Professor
Current research interest:A) Understanding the proteostasis process within the nucleus with special emphasis on identifying the role of heat shock protein 90 and its clients in various DNA-associated pathways: Grant: DBT (2013-2017), CSIR (2016-
2019)1) 2019: mSphere2) 2018: mSphere3) 2016: Molecular Biology of the Cell4) 2015: Frontiers in Oncology5) 2014: Molecular and Cellular Biology6) 2014: Eukaryotic Cell7) 2011: PLoS One
B) Functional characterization of topoisomerases in malaria parasite anddevelopment of anti-malaria compounds targeted to topoisomerases: Grant: CSIR(2012-2015), DST (2018-2021)
8) 2019: JBC9) 2017: Molecular and Biochemical Parasitology
10) 2015: mSphere11) 2015: PLoS One12) 2014: Molecular Microbiology 13) 2014: Antimicrobial Agents and Chemotherapy 14) 2013: Molecular and Biochemical Parasitology
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Publications:
• Gatreddi S, Pillalamarri V, Vasudevan D, Addlagatta A, Qureshi IA (2019).
Unraveling structural insights of ribokinase from Leishmania donovani.
International Journal of Biological Macromolecules 136:253-265.
• Qureshi R, Jakkula P, Sagurthi SR, Qureshi IA (2019). Protein phosphatase
1 of Leishmania donovani exhibits conserved catalytic residues and pro-
inflammatory response. Biochemical and Biophysical Research
Communications 516:770-776.
• Goud NS, Ghouse SM, Vishnu J, Komal D, Talla V, Alvala R, Pranay J,
Kumar J, Qureshi IA, Alvala M (2019). Synthesis of 1-benzyl-1H-
benzimidazoles as galectin-1 mediated anticancer agents. Bioorganic
Chemistry 89:103016.
• Goud NS, Pooladanda V, Mahammad SG, Jakkula P, Gatreddi S, Qureshi
IA, Alvala R, Godugu C, Alvala M (2019). Synthesis and Biological
evaluation of morpholines linked coumarin-triazole hybrids as anticancer
Ahmed Qureshi
Professor, Department of Biotechnology & Bioinformatics
Life Sciences, University of Hyderabad, Hyderabad (India)
interest: Molecular and Structural Biology
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Laboratory of Molecular Immunology and Infectious diseases
Dr. Nooruddin Khan, PhDAssistant Professor, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, IndiaCourtesy Assistant Professor, College of Veterinary Medicine; Cornell University, USA
Publications:
Research Interest: Molecular Immunology, Infectious diseases, vaccine and adjuvant engineering
•Khan RA, Afroz S, Minhas G, Battu S, Khan N. Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome. Cytokine. 2019 Jul 22;123:154780. doi: 10.1016/j.cyto.2019.154780. [Epub ahead of print]
•lvi SB, Appidi T, Deepak BP, Rajalakshmi PS, Minhas G, Singh SP, Begum A, Bantal V, Srivastava R, Khan N, Rengan AK. The "nano to micro" transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy. Biomater Sci. 2019 Jul 16. doi: 10.1039/c9bm00932a. [Epub ahead of print]
microbial Nano vesicle based multivalent Vaccine formulation against multiple poultry disease under DBT BIRAC
based approach to develop tetravalent vaccine against Dengue Virus by ICMR (32.5 lakhs)
talk entitled "Novel Vaccine and Adjuvant discovery platform at the " DBT-NIAID Vaccine Adjuvant Science Collaborative
April, 2019 in New Delhi.
invited talk at the Ind-CEPI Mission of Department of Biotechnology, “Epidemic preparedness through rapid vaccine developmen“
Biotechnology Industry Research Application Council (BIRAC) held on August 01, 2019 at Scope Complex, New Delhi
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Mechanisms of Neurodegenerative
Diseases
1) Mechanism of Tau and Fyn mediated neurodegeneration in Alzheimer’s disease
2) Mitochondrial dynamics in aging and neurodegenerative diseases
Neurological circuits in sleep and circadian
regulation
Role and function of sleep in health and disease
Model System: Drosophila melanogaster
Dr. Madhubabu G.B., Assistant Professor
Laboratory of Neurobiology
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Dr. Pankaj Singh Dholaniya
Research interest
• Application of machine learning methods for complex disease
modeling.
• Modeling gene interaction networks.
• Understanding the mechanism of neuronal senescence and age
associated neurological disorders.
• Kakade A., Kumari B., Dholaniya P.S., Feature selection
using logistic regression in case–control DNA methylation
data of Parkinson’s disease: A comparative study, Journal
of Theoretical Biology (2018),
https://doi.org/10.1016/j.jtbi.2018.08.018
Bioinformatics Data Science Group
Publication
Assistant Professor
Department of Biotechnology and Bioinformatics
School of Life Sciences, University of Hyderabad, Hyderabad
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Thank you
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Teaching Programs
MSc (Biotechnology) - 1991
JNU – CEEB (DBT, NewDelhi)
20 students
Int-MSc-PhD (Biotechnology) - 2010
All India entrance exam & Interview
6 students
MTech
(Bioinformatics)
- 2006
GATE Rank
(CCMT) - AICTE
23 students
(Biology & Non-biology)
PhD
(Biotechnology) -
2008
All India entrance
exam & Interview
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Name of Faculty
DST DBT
UGC
CSIR ICMR
UPE
Consultancy
AnyOther (India)
Abroad(Name)
Total
AKK 60 60
PPB 123 120 --- 25 10 30 10 318
KPS 21.94
74.66
5.94
21.33
8.5 4.7 137
JSSP
MVR 52.7 52.7
VV
NPP 30 18 10 3 61 (approx)
SBT 72.28
40 44.42
8 163
IAQ 65.258
- 7.875
20.0 - 6.5 - - - 99.615
MB 40 5 45
Extra-mural Funding Mobilised from Department (2010
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Regarding the student achievements:
1. Lingaswamy Bantu: (11LTPH17) is working as a
"CHEMICAL ASSISTANT" in Office of the Principal
Commissioner of Customs, Government of India, Mumbai
2. Krishna Priya (17LSMI03) is working in TCS innovation
labs as a software developer on NGS platform
3. Naina Tiwari ( ) also got the job in TCS innovation labs
and working on NGS platform. Her DoBB registration
number you may get it from office, I do not know.
4. Azaz P ( ) he is also our M.Sc., Biotechnology just
completed this year got TIGP fellowship in "Tiwan
International Graduate programme", Academia Sinica,
Taiwan.
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Department of Systems & Computational Biology(DoSCB)
(http://doscb.uohyd.ac.in)
School of Life Sciences(SLS)
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The Department
The Department of Systems and Computational
Biology (DoSCB) (erstwhile Virtual Centre for
Systems Biology) is the fifth department in the
School of Life Sciences. It was established as per
the statute 17(5)(a)&(b) of University of
Hyderabad based on a resolution passed by its
Executive
Council on 30th September 2018
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The Faculty Members
• Prof. H. A. Nagarajaram - Professor & Head
• Dr. Vivek - Assistant Professor
• Dr. Manjari Kiran - Assistant Professor
• Dr. Sivahari Prasad Gorintla - Assistant
Professor
(UGC-FRP)
. Dr. Rakesh Pandey – INSPIRE
Faculty
Adjunct Professors
• Dr. Shekhar Mande, DG-CSIR
• Dr. Rajeev Varshney, ICRISAT
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The Courses Offered• Five year Integrated Master’s course in Systems Biology (IntMSc(Syst Biol)),
being offered in conjunction with College of Integrated Studies (CIS), University
of Hyderabad
• This course encompasses an interdisciplinary approach that is developed
with changing nature of current biological research
• The students are trained in analyzing complex molecular systems and
high-throughput biological data.
• Many of the students of IntMSc(Syst Biol) are either placed in
biologicals/pharma companies or pursuing their PhDs and beyond the
University of Hyderabad or other universities and research institutes in
India and abroad.
• PhD in Systems and Computational Biology
First batch (2019) – 4
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Systems Biology
Computational Biology
Bioinformatics
Genomics
DOSCB-RESEARCH
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ResearchSystems biology
• Construction and analyses of spatio-temporal and context dependent (for ex: viral infection) human protein-protein interaction networks and deciphering topological roles and properties of human proteins and their interacting partners in those networks
• Drug-protein interaction networks: Topological properties of targets of approved versus withdrawn drugs
• Roles of products of HTGs in PPINs• Signalling and Regulatory Networks• Pathogenesis of Inflammatory skin diseases,
Psoriasis and Atopic Dermatitis• Synthetic Gene Circuits
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Research (contd…)Disease Informatics & Biomarker Discovery
o Analyses of functional impacts of human missense mutations on protein structure, function and interactions
o Analyses of loss/gain of function mutations o Development of novel prediction toolso Analyses of Human Volatilome toward cancer
biomarker discovery o Identification of potential prognostic signatures for
predicting survival in cancerso non-cancer drug repositioning
Cancer Biology o Understanding the drug resistance mechanisms in leukemia models and
solid tumors against targeted therapies.
o Generation of Leukemia models
o Identification of novel therapeutic agents in Leukemia
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Research (contd…)
Protein Structures and Evolution o Development of novel protein structure prediction toolso Analysis of structural variability and evolution of disordered regions
and investigating into “Structure-Disorder-Function” paradigm
Non-coding RNA Biology o Identification and characterisation of novel non-coding RNAs
Genomics & Metagenomics o Metagenome analyses of gut and root microbiota in healthy and
disease conditions and also the bacteria thriving near industrial effluent plants
o Integration of various ‘omics’ data for gene knowledge mining and genome annotation
o Neutri-genomics for important crops
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Publications by the faculty members
• About 100 publications in peer-reviewed
international journals such as PNAS,
J.Proteome Res, NAR, etc
• One Indian Patent filed
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Investigators:
Prof. José Sousa Câmara, PI, University of Madeira, Portugal
Prof. Schubert, Rostock Medical Centre, PI, Rostock, Germany
Dr. Srikanth Rapole, PI, NCCS, Pune, India
Prof..Nagarajaram, PI, DoSCB, UoH, Hyderabad, India
1. NCDs-CAPomics: Exploring the Volatome of
NonCommunicable Diseases as a Promising Non-
Invasive and Integrating Approach for its Rapid
Diagnostics. The Case Study of Cancer and
Neurodegenerative Diseases (2019-2022) (II Phase)
Extramural Funding
Investigators:
Prof. Bramandam Manavathi, PI, Dept. Biochemistry, SLS
Prof..Nagarajaram, Co-PI, DoSCB, UoH, Hyderabad, India
2. Nucleolus in control of breast tumor
heterogeneity
A MHRD, Government of India under
“Scheme for Translational and Advanced
Research in Sciences (STAR)”
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Investigators:
Prof. Dayananda, Coordinator and PI, Dept. Animal Sciences, SLS,
UoH
Prof. Venkataramana, Co-PI, Dept. Plant Sciences, SLS, UoH
Prof. Nagarajaram, Co-PI, DoSCB, SLS, UoH
Chemical and genomic approaches to investigate possible link between
development of antimicrobial resistance (AMR) and pharma industry
effluents (2019-2021)
supported by a grant from Bulk Drug Manufacturers Association of
India (BDMAI)
Industry Funding
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Fellowships
1. Ramalingaswamy Fellowship
Dr. Vivek
2. DST-INSPIRE Faculty
Dr. Rakesh Pandey
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Thank You
School of Life Sciences