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Transcript of Odontogenic tumors-2002-02-slides
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Odontogenic Cysts and Tumors
Michael Underbrink, MD
Anna Pou, MDFebruary 13, 2002
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IntroductionVariety of cysts and tumors Uniquely derived from tissues of
developing teethMay present to otolaryngologist
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OdontogenesisProjections of dental lamina into
ectomesenchymeLayered cap (inner/outer enamel
epithelium, stratum intermedium, stellate reticulum)
Odontoblasts secrete dentin ameloblasts (from IEE) enamel
Cementoblasts cementumFibroblasts periodontal membrane
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Odontogenesis
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DiagnosisComplete history
Pain, loose teeth, occlusion, swellings, dysthesias, delayed tooth eruption
Thorough physical examination Inspection, palpation, percussion,
auscultationPlain radiographs
Panorex, dental radiographsCT for larger, aggressive lesions
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DiagnosisDifferential diagnosisObtain tissue
FNA – r/o vascular lesions, inflammatory Excisional biopsy – smaller cysts,
unilocular tumors Incisional biopsy – larger lesions prior to
definitive therapy
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Odontogenic Cysts Inflammatory
Radicular Paradental
Developmental Dentigerous Developmental
lateral periodontal Odontogenic
keratocyst Glandular
odontogenic
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Radicular (Periapical) CystMost common (65%)Epithelial cell rests of MalassezResponse to inflammationRadiographic findings
Pulpless, nonvital tooth Small well-defined periapical radiolucency
Histology Treatment – extraction, root canal
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Radicular Cyst
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Radicular Cyst
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Residual Cyst
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Paradental CystAssociated with partially impacted 3rd
molars Result of inflammation of the gingiva
over an erupting molar0.5 to 4% of cystsRadiology – radiolucency in apical
portion of the rootTreatment – enucleation
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Paradental Cyst
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Dentigerous (follicular) CystMost common developmental cyst (24%)Fluid between reduced enamel epithelium
and tooth crownRadiographic findings
Unilocular radiolucency with well-defined sclerotic margins
Histology Nonkeratinizing squamous epithelium
Treatment – enucleation, decompression
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Dentigerous Cyst
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Dentigerous Cyst
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Developmental Lateral Periodontal Cyst From epithelial rests in periodontal ligament
vs. primordial cyst – tooth bud Mandibular premolar region Middle-aged men Radiographic findings
Interradicular radiolucency, well-defined margins Histology
Nonkeratinizing stratified squamous or cuboidal epithelium
Treatment – enucleation, curettage with preservation of adjacent teeth
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Developmental Lateral Periodontal Cyst
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Odontogenic Keratocyst11% of jaw cystsMay mimic any of the other cystsMost often in mandibular ramus and
angleRadiographically
Well-marginated, radiolucency Pericoronal, inter-radicular, or pericoronal Multilocular
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Odontogenic Keratocyst
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Odontogenic Keratocyst
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Odontogenic KeratocystHistology
Thin epithelial lining with underlying connective tissue (collagen and epithelial nests)
Secondary inflammation may mask featuresHigh frequency of recurrence (up to 62%)Complete removal difficult and satellite
cysts can be left behind
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Odontogenic Keratocyst
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Treatment of OKC Depends on extent of lesion Small – simple enucleation, complete removal
of cyst wall Larger – enucleation with/without peripheral
ostectomy Bataineh,et al, promote complete resection
with 1 cm bony margins (if extension through cortex, overlying soft tissues excised)
Long term follow-up required (5-10 years)
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Glandular Odontogenic CystMore recently described (45 cases)Gardner, 1988Mandible (87%), usually anteriorVery slow progressive growth (CC:
swelling, pain [40%])Radiographic findings
Unilocular or multilocular radiolucency
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Glandular Odontogenic Cyst
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Glandular Odontogenic Cyst Histology
Stratified epithelium Cuboidal, ciliated
surface lining cells Polycystic with
secretory and epithelial elements
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Treatment of GOCConsiderable recurrence potential 25% after enucleation or curettageMarginal resection suggested for larger
lesions or involvement of posterior maxillaWarrants close follow-up
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Nonodontogenic Cysts Incisive Canal CystStafne Bone CystTraumatic Bone CystSurgical Ciliated Cyst (of Maxilla)
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Incisive Canal CystDerived from epithelial remnants of the
nasopalatine duct (incisive canal)4th to 6th decadesPalatal swelling common, asymptomaticRadiographic findings
Well-delineated oval radiolucency between maxillary incisors, root resorption occasional
Histology Cyst lined by stratified squamous or
respiratory epithelium or both
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Incisive Canal Cyst
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Incisive Canal CystTreatment consists of surgical
enucleation or periodic radiographsProgressive enlargement requires
surgical intervention
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Stafne Bone CystSubmandibular salivary gland depression Incidental finding, not a true cystRadiographs – small, circular, corticated
radiolucency below mandibular canalHistology – normal salivary tissueTreatment – routine follow up
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Stafne Bone Cyst
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Traumatic Bone CystEmpty or fluid filled cavity associated
with jaw trauma (50%)Radiographic findings
Radiolucency, most commonly in body or anterior portion of mandible
Histology – thin membrane of fibrous granulation
Treatment – exploratory surgery may expedite healing
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Traumatic Bone Cyst
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Surgical Ciliated CystMay occur following Caldwell-LucTrapped fragments of sinus epithelium
that undergo benign proliferationRadiographic findings
Unilocular radiolucency in maxillaHistology
Lining of pseudostratified columnar ciliatedTreatment - enucleation
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Surgical Ciliated Cyst
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Odontogenic Tumors Ameloblastoma Calcifying Epithelial
Odontogenic Tumor Adenomatoid
Odontogenic Tumor
Squamous Odontogenic Tumor
Calcifying Odontogenic Cyst
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AmeloblastomaMost common odontogenic tumorBenign, but locally invasiveClinically and histologically similar to BCCa4th and 5th decadesOccasionally arise from dentigerous cystsSubtypes – multicystic (86%), unicystic
(13%), and peripheral (extraosseous – 1%)
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AmeloblastomaRadiographic findings
Classic – multilocular radiolucency of posterior mandible
Well-circumscribed, soap-bubble Unilocular – often confused with
odontogenic cysts Root resorption – associated with
malignancy
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Ameloblastoma
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AmeloblastomaHistology
Two patterns – plexiform and follicular (no bearing on prognosis)
Classic – sheets and islands of tumor cells, outer rim of ameloblasts is polarized away from basement membrane
Center looks like stellate reticulum Squamous differentiation (1%) – Diagnosed
as ameloblastic carcinoma
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Ameloblastoma
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Treatment of Ameloblastoma According to growth characteristics and type Unicystic
Complete removal Peripheral ostectomies if extension through cyst
wall Classic infiltrative (aggressive)
Mandibular – adequate normal bone around margins of resection
Maxillary – more aggressive surgery, 1.5 cm margins
Ameloblastic carcinoma Radical surgical resection (like SCCa) Neck dissection for LAN
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Calcifying Epithelial Odontogenic Tumora.k.a. Pindborg tumorAggressive tumor of epithelial derivation Impacted tooth, mandible body/ramusChief sign – cortical expansionPain not normally a complaint
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Calcifying Epithelial Odontogenic TumorRadiographic findings
Expanded cortices in all dimensions Radiolucent; poorly defined, noncorticated
borders Unilocular, multilocular, or “moth-eaten” “Driven-snow” appearance from multiple
radiopaque foci Root divergence/resorption; impacted tooth
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Calcifying Epithelial Odontogenic Tumor
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Calcifying Epithelial Odontogenic TumorHistology
Islands of eosinophilic epithelial cells Cells infiltrate bony trabeculae Nuclear hyperchromatism and
pleomorphism Psammoma-like calcifications (Liesegang
rings)
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Calcifying Epithelial Odontogenic Tumor
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Treatment of CEOTBehaves like ameloblastomaSmaller recurrence ratesEn bloc resection, hemimandibulectomy
partial maxillectomy suggested
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Adenomatoid Odontogenic Tumor Associated with the crown of an impacted
anterior tooth Painless expansion Radiographic findings
Well-defined expansile radiolucency Root divergence, calcified flecks (“target”)
Histology Thick fibrous capsule, clusters of spindle cells,
columnar cells (rosettes, ductal) throughout
Treatment – enucleation, recurrence is rare
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Adenomatoid Odontogenic Tumor
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Squamous Odontogenic Tumor Hamartomatous proliferation Maxillary incisor-canine and mandibular molar Tooth mobility common complaint Radiology – triangular, localized radiolucency
between contiguous teeth Histology – oval nest of squamous epithelium
in mature collagen stroma Treatment – extraction of involved tooth and
thorough curettage; maxillary – more extensive resection; recurrences – treat with aggressive resection
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Squamous Odontogenic Tumor
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Calcifying Odontogenic Cyst Tumor-like cyst of mandibular premolar region ¼ are peripheral – gingival swelling Osseous lesions – expansion, vital teeth Radiographic findings
Radiolucency with progressive calcification Target lesion (lucent halo); root divergence
Histology Stratified squamous epithelial lining Polarized basal layer, lumen contains ghost cells
Treatment – enucleation with curettage; rarely recur
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Mesenchymal Odontogenic TumorsOdontogenic MyxomaCementoblastoma
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Odontogenic MyxomaOriginates from dental papilla or
follicular mesenchymeSlow growing, aggressively invasiveMultilocular, expansile; impacted teeth?Radiology – radiolucency with septaeHistology – spindle/stellate fibroblasts
with basophilic ground substanceTreatment – en bloc resection,
curettage may be attempted if fibrotic
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Cementoblastoma True neoplasm of cementoblasts First mandibular molars Cortex expanded without pain Involved tooth ankylosed, percussion Radiology – apical mass; lucent or solid,
radiolucent halo with dense lesions Histology – radially oriented trabeculae from
cementum, rim of osteoblasts Treatment – complete excision and tooth
sacrifice
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Cementoblastoma
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Mixed Odontogenic TumorsAmeloblastic fibroma, ameloblastic
fibrodentinoma, ameloblastic fibro-odontoma, odontoma
Both epithelial and mesenchymal cellsMimic differentiation of developing toothTreatment – enucleation, thorough
curettage with extraction of impacted toothAmeloblastic fibrosarcomas – malignant,
treat with aggressive en bloc resection
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Related Jaw Lesions Giant Cell Lesions
Central giant cell granuloma
Brown tumor Aneurysmal bone
cyst
Fibroosseous lesions Fibrous dysplasia Ossifying fibroma
Condensing Osteitis
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Central Giant Cell GranulomaNeoplastic-like reactive proliferationCommon in children and young adultsFemales > males (hormonal?)Mandible > maxillaExpansile lesions – root resorptionSlow-growing – asymptomatic swellingRapid-growing – pain, loose dentition
(high rate of recurrence)
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Central Giant Cell GranulomaRadiographic findings
Unilocular, multilocular radiolucencies Well-defined or irregular borders
Histology Multinucleated giant cells, dispersed
throughout a fibrovascular stroma
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Central Giant Cell Granuloma
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Central Giant Cell Granuloma
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Central Giant Cell GranulomaTreatment
Curettage, segmental resection Radiation – out of favor (risk of sarcoma) Intralesional steroids – younger patients,
very large lesions Individualized treatment depending on
characteristics and location of tumor
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Brown TumorLocal manifestation of hyperparathyroidHistologically identical to CGCGSerum calcium and phosphorusMore likely in older patients
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Aneurysmal Bone CystLarge vascular sinusoids (no bruit)Not a true cyst; aggressive, reactiveGreat potential for growth, deformityMultilocular radiolucency with cortical
expansionMandible bodySimple enucleation, rare recurrence
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Fibrous DysplasiaMonostotic vs. polystoticMonostotic
More common in jaws and craniumPolystotic
McCune-Albright’s syndrome Cutaneous pigmentation, hyper-functioning
endocrine glands, precocious puberty
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Fibrous DysplasiaPainless expansile dysplastic process of
osteoprogenitor connective tissueMaxilla most common Does not typically cross midline (one bone)Antrum obliterated, orbital floor
involvement (globe displacement)Radiology – ground-glass appearance
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Fibrous Dysplasia
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Fibrous Dysplasia
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Fibrous DysplasiaHistology – irregular osseous trabeculae in
hypercellular fibrous stromaTreatment
Deferred, if possible until skeletal maturity Quarterly clinical and radiographic f/u If quiescent – contour excision (cosmesis or
function) Accelerated growth or disabling functional
impairment - surgical intervention (en bloc resection, reconstruction)
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Ossifying FibromaTrue neoplasm of medullary jawsElements of periodontal ligamentYounger patients, premolar – mandibleFrequently grow to expand jaw boneRadiology
radiolucent lesion early, well-demarcated Progressive calcification (radiopaque – 6 yrs)
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Ossifying Fibroma
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Ossifying FibromaHistologically similar to fibrous dysplasiaTreatment
Surgical excision – shells out Recurrence is uncommon
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Condensing Osteitis4% to 8% of populationFocal areas of radiodense sclerotic boneMandible, apices of first molarReactive bony sclerosis to pulp
inflammation Irregular, radiopaqueStable, no treatment required
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Condensing Osteitis
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Conclusion
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Case Presentation20 year-old hispanic female with several
month history of lesion in right maxilla, treated initially by oral surgeon with multiple curettage.
Has experienced recent onset of rapid expansion, after pregnancy, with complaints of loose dentition and pain.
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Physical Examination
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Physical Examination
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RadiographsPlain films – facial seriesComputerized Tomography of facial
series
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Pathology
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Treatment
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Treatment