October 1st - 2nd, 2019 Catanzaro, Italy...October 1st - 2nd, 2019 Catanzaro, Italy 1st...
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October 1 st - 2 nd , 2019 Catanzaro, Italy 1 st International and 32 nd Annual Conference of Italian Association of Cell Cultures (AICC) From Single Gene Analysis to Single Cell Profiling: A New Era for Genomic Medicine Università Magna Græcia, Catanzaro Aula Magna C Level 1, building G PROGRAMME 32 nd Annual Conference 1 International and st
Transcript of October 1st - 2nd, 2019 Catanzaro, Italy...October 1st - 2nd, 2019 Catanzaro, Italy 1st...
October 1st - 2nd, 2019Catanzaro, Italy
1st International and 32nd Annual Conference of Italian Association of Cell Cultures (AICC)
From Single Gene Analysis to Single Cell Profiling: A New Era for Genomic MedicineUniversità Magna Græcia, CatanzaroAula Magna CLevel 1, building G
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Molecular profiling of DNA and RNA has provided valuable newinsights into the gene;c basis of non-malignant and malignantdisorders. These advances have important implica;ons for futureresearch as well as clinical prac;ce in areas such as moleculardiagnos;cs,gene/pathway-directedtargetedtherapy,whichinturncoulddrivedrugdiscovery.Itiswellknownthatbothinheritedandsoma;cgene;caltera;onscontributetodiseasepredisposi;onandprogression, but also shape responsiveness to therapy andtreatmentcomplica;ons.
Recent technological advances have enabled the analyses ofgenomic and epigenomic varia;on in a comprehensive, high-throughput fashion using next genera;on sequencing (NGS). NGShasradicallytransformedcancerresearch,showingthateachtumortype typically exhibits dis;nct constella;ons of gene;c altera;onstarge;ng one or more key cellular pathways that regulate cellgrowthandprolifera;on,evasionoftheimmunesystem,andotheraspects of cancer behavior. These gene;c and epigene;c eventshavebeeniden;fiedandmaynowbeusedasprognos;cmarkersorfor monitoring disease progression and treatment response, astargets fornew therapies, and in the seKngof gene;c counselinganddiseasesurveillance.
The conferencewants to offer the par;cipants the opportunity tomatch technological solu;ons and clinical needs in the era ofprecision medicine. From circula;ng biomarkers to muta;onal,transcriptomicsand immunomics landscape, thisyearmee;ngwilldescribeapanoramaof the renewedplaNorms forpersonaliza;onoftherapy.
Themee;ngPresidentMariaTeresaDiMar*no
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Day1-October1st
9:00 Openingceremony Gree'ngsfromAcademicandAICCauthori'es
Chairs:PierosandroTagliaferri,PierfrancescoTassone
9:20 KeynotelectureInducingphenotypes,discoveringthem,andinstantlysolvingthemBruceA.Beutler,Dallas,TX
10:00 Dis;nguishedlecture-Day1TheBAP1cancersyndrome:uniquemechanismsandclinicalcharacteris'csrequiringspecificmedicalapproachesMicheleCarbone,Honolulu,HI
10:30-11:00 CoffeeBreakandpostervisit
11:00-12:50 SESSIONIBiomarkersfordiagnosis,monitoringofprogressionandtherapeu;cresponseThedevelopmentofnewtechnologyandclinicalstandardsfordiscoveryanduseofbiomarkersindiseasediagnosis,monitoringandresponsetotherapy.Chairs:StefaniaMeschini,Ka8aScotlandi
11:05 PrecisionMedicineandnon-communicablediseasesGiuseppeNovelli,Rome,IT
11:25 Microenvironment-drivenheterogeneityincancer:morphologicalviewsClaudioTripodo,Palermo,IT
11:45 PD-L1andbeyond:fromPD-L1detec'ontothetumormuta'onburden AndreaRonchi,Naples,IT
12:05 Evolu'onofliquidbiopsyconceptinoncologyUmbertoMalapelle,Naples,IT
12:25 BRCA-1promotermethyla'onstatusinBRCAmutatedovariancancer:correla'onwithresponsetoPARPinhibitors AngelaLombardi,Naples,IT(P54)
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12:35 Anovelcellcharacteriza'ontechniquebasedoninfrared-inducedpyroelectriceffectSalvatoreA.Pullano,Catanzaro,IT(P21)
12:50-13:50 Lightlunchandpostervisit
13:50-15:20 SESSIONIISinglecellprofiling:frombenchtobedsideHighlightsontheuseofsingle-cellgenomicstoincreaseourunderstandingofthetumormicroenvironmentandiden'fynewtherapeu'ctargets.Chairs:ChiaraRigan8,CarloLeone;
13:55 UnderstandingthemolecularmechanismsunderlyingTlymphocytedifferen'a'onandplas'cityusingSingleCellRNA-SeqMassimilianoPagani,Milan,IT
14:15 Genomicprinciplesofsignalintegra'oninmacrophagesRenatoOstuni,Milan,IT
14:35 SingleCelltranscriptomicsuncoversdis'nctmolecularsignaturesoftherapy-resistantleukemicstemcellsAliceGiustacchini,London,UK
14:55 Iden'fyinguniquemoleculartargetsandusingnovelgenegroupbasedshotguntreatmentsinmalignantpleuralmesotheliomaPreetaAnanthanarayanan,Turin,IT(P11)
15:05 Targe'ngLSD1/UTXasatherapeu'cop'oninbreastcancerRosariaBenedeK,Naples,IT(P50)
15:20-15:50 CoffeeBreakandpostervisit
15:50-16:55 TECHNICALSESSIONIInsightsinsinglegeneanalysistechnologiesThesec'onwillincludeinnova'vetechnologiesforsingleeventsiden'fica'onfromdifferentbiologicalmatricesanddifferenthumandiseases.Chair:MarcoRossi,FrancescoTrapasso
15:55 Bringingprecisiononcologyclosertopa'ents FedericaBer;,ThermofisherScien;ficPR
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16:10 Roleofpolychroma'cflowcytometryandcellsor'ngintheevalua'onofminimalresidualdiseaseinacuteleukemiasFrancescoGervasi,BeckmanCoulter
16:25 Automa'onandlivecellimaging:anewapproachincontractresearchforan'cancerdrugdiscovery FrancescoP.Fioren;no,KitosBiotech/GilsonItaliaSRL
16:40 Howtoresolveheterogeneity:BDmul'omicssolu'onGianlucaRo\aandWernerRodriguez,BectonDickinsonItalia
16:55 DiscussionandDay1take-homemessage
19:00-23:00 SocialEvent
Day2-October2nd
9:00-10:50 SESSIONIIIFunc;onalgenomicsinclinicalprac;ceThissec'onwillhighlighttheroleof«precisionfunc'onalgenomics»inphenotypicallycharacterizinggene'cvariantsatscale.Chairs:FrancescaZazzeroni,EnricoDeSmaele
9:05 Genomicinstabilityinmul'plemyelomaDanieleCaracciolo,Catanzaro,IT
9:25 Genomiclandscapeofpancrea'cneuroendocrinetumorsAndreaMafficini,Verona,IT
9:45 Analysisofcancergenomicdatatoachievebe`erpa'entstra'fica'onandpersonalizedmolecularprofilingJavierDeLasRivas,Salamanca,ES
10:05 Novelmechanismsoftumorsuppression GiovanniTonon,Milan,IT
10:25 Themito'ccheckpointproteinMAD2isregulatedbythetumorsuppressorKCASH2KCTD21 MartaMoreK,Rome,IT(P12)
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Day2-October2nd
10:35 Phagedisplay-derivedpep'desastoolforsingleBcellpopula'onstarge'nginpolyclonalCLLpa'ents SelenaMimmi,Catanzaro,IT(P14)
10:50-11:20 CoffeeBreakandpostervisit
11:20 Dis;nguishedLecture-Day2ZNF281contributestotheDNAdamageresponseandisaprognos'cmarkerforneuroblastoma GerryMelino,Rome,IT
11:50-12:50 TECHNICALSESSIONIIInsightsinsinglecellprofilingtechnologiesThesec'onwillincludeinnova'vetechnologiesforhighthroughputtranscriptomics,genomics,proteomics,immunomics,miRNomicsanalysisandinvivomodelsforthedissec'onoftumormicroenvironment.Chairs:DanieleTorella,CarmelaDeMarco
11:55 Zebrafishmodelforneuroendocrinetumors:aninvivoplaeormforpersonalizedtherapyGiovanniVitale,Milan,IT
12:10 Biologyattrueresolu'onwith10XGenomicsDiegoMuzzini,CarloErbaReagents
12:25 QIAGENbioinforma'csinNGS:fromfastqtointerpreta'on,howtoanalyzesoma'candgermlinemuta'onsandexpressionprofilingMitaMancini,Qiagen
12:40 Discussion
12:50-13:50 Lightlunchandpostervisit
13:50-15:35 SESSIONIVFunc;onalimmunomicsinprecisionmedicineThesec'onwilldealwiththeuseofimmunomicsasanewresearchtoolinsystembiologyofcellularimmuneresponses,andhowthiscanbeexploitedtoamelioratecancerimmunotherapyChairs:MarcelloMaggiolini,MassimoDonadelli
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13:55 Inflammosomicsinthepredic'onofresponsetoimmunotherapyPierpaoloCorreale,ReggioCalabria,IT
14:15 Iden'fica'onofan'genictargetsforcancerimmunotherapyLuigiBuonaguro,Naples,IT
14:35 Cancerclonalevolu'onastherapeu'ctargetSabrinaArena,Turin,IT
14:55 ClosinglectureDrivingtheCARbeyondthecheckpointsFrancescoMarincola,California,USA
15:35 AWARDCEREMONY
16:00 CLOSINGREMARKS
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AICCScien;ficBoard
President MicheleCaraglia,UniversitàVanvitellidiNapoli,Naples(IT)
Vicepresident StefaniaMeschini,Is'tutoSuperiorediSanità,Rome(IT)
BoardofDirectorsandSecretary MassimoDonadelli,UniversitàdiVerona,Verona(IT)
BoardofDirectorsandTreasurerFrancescaZazzeroni,UniversitàdegliStudidell’Aquila,L’Aquila(IT)
BoardofDirectorsMariaTeresaDiMar;no,UniversitàMagnaGræcia,Catanzaro(IT) ChiaraRigan;,UniversitàdiTorino,Turin(IT) EnricoDeSmaele,UniversitàLaSapienza,Rome(IT)
PastPresident Ka;aScotlandi,IRCCSIs'tutoOrtopedicoRizzoli,Bologna(IT)
AICCSecretariat
MassimoDonadelli([email protected]) EvelinPellegrini([email protected])Mee'nge-mail:[email protected]
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FacultySabrinaArena,Is'tutodiCandiolo-IRCCS,Turin(IT)FedericaBer;,ThermofisherScien'fic,Monza(IT)BruceA.Beutler,UTSouthwesternMedicalCenter,Dallas(TX)LuigiBuonaguro,IRCSSFondazioneG.Pascale,Naples(IT)DanieleCaracciolo,UniversitàdegliStudiMagnaGræciadiCatanzaro,Catanzaro(IT)MicheleCarbone,UniversityofHawaiiCancerCenter,Honolulu(HI) PierpaoloCorreale,GrandeOspedaleMetropolitano,ReggioCalabria(IT)JavierDeLasRivas,UniversityofSalamanca,Salamanca(ES)FrancescoP.Fioren;no,KitosBiotech/GilsonItaliaSRLFrancescoGervasi,BeckmanCoulter,Palermo(IT)AliceGiustacchini,UniversityCollegeLondon,London(UK)AndreaMafficini,UniversityofVerona,Verona(IT) UmbertoMalapelle,UniversitàdegliStudidiNapoliFedericoII,Naples(IT)MitaMancini,Qiagen,Berlin(DE)FrancescoMarincola,RefugeBiotechnologies,MenloPark(CA)GerryMelino,UniversitàTorVergata,Rome(IT)DiegoMuzzini,CarloErbaReagents,Milan(IT) RenatoOstuni,SanRaffaeleTelethonIns'tuteforGeneTherapy(SR-Tiget),Milan(IT)GiuseppeNovelli,UniversitàTorVergata,Rome(IT) MassimilianoPagani,UniversitàdegliStudidiMilano,Milan(IT)WernerRodriguez,BectonDickinsonItaliaAndreaRonchi,IRCSSFondazioneG.Pascale,Naples(IT)GianlucaRo\a,BectonDickinsonItaliaGiovanniTonon,UniversitàVita-SaluteSanRaffaele,Milan(IT)ClaudioTripodo,UniversitàdegliStudidiPalermo,Palermo(IT)GiovanniVitale,UniversitàdegliStudidiMilano,Milan(IT)
Localorganizingcommi\eeEmanuelaAltomare MariamenaArbitrioDanieleCaracciolo MichelangeloIannone MarcelloMaggioliniMarcoRossiFrancescaScion; PierosandroTagliaferri PierfrancescoTassone GiuseppeViglie\oPROGRAM
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Addi;onalinforma;onLanguage:themee'ngofficiallanguageisEnglish.Slides:slidesmustbewri`eninEnglish,andshouldbehandedtotheslidecentreonehourbeforethebeginningofeachsession.Computervideoprojec'onwillbeavailableinPowerPointformat.A`endancecer'ficate:acer'ficateofa`endancewillbesenttoallpar'cipantsattheendofthemee'ng.
Mee'ngWiFi:UMGospi'-KEYWPA2:3333333333(10'mes3) User:aicc.umgPassword:Aicc.umg19
Generalinforma;onWhen:October1st-2nd,2019
Where:UniversitàMagnaGræcia-CampusSalvatoreVenuta-AulaMagnaC,Level1,BuildingG-VialeEuropa-88100Catanzaro,Italy
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Registra;onfees
Thepar'cipa'ontotheconferenceisreservedtoAICCandGISMmembers.Registra'onfeesinclude:-Admissiontoallmee'ngsessionsandexhibi'onareas -Abstractbook-A`endancecer'ficate-Conferencekit -Coffeebreak,lightlunch,socialevent*Pleaseindicateanyfoodintoleranceontheregistra8onform.Registra'onfeesdonotincludetravelandaccommoda'oncosts.Theregistra'onformandpaymentdetailsareavailableonlineatthelink:www.aicc.websiteRegistra'onwithoutpaymentisnotconsideredvalid.Themaximumnumberofpar'cipantsis160.
Mee'ngfee(VATincluded)
AnnualMembership
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AICC/GISMmembers-En;redura;on 200,00 200,00Non-members-En;redura;on 200,00 50,00 250,00AICC/GISMmembers-One-dayregistra;on
100,00 100,00Non-members-One-dayregistra;on 100,00 50,00 150,00Onsiteregistra;on 200,00 50,00 250,00UndergraduateandPhDStudents 50,00 50,00
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AwardsAICCwillawardanumberofprizesforbestoralorposterpresenta'onbyauthorsyoungerthan35yearsofage.Eachawardisworth500euros.One500europrizewillbeawardedtothebestposterpresenta'onbyanauthoryoungerthan35yearsofagebytheJournalofExperimentalandClinicalCancerResearch.
SocialEventAllpar'cipantswillbeadmi`edtoaguidedtourofCatanzarooldcity.Thiswillbefollowedbyasocialdinnerheldinthebeau'fulSanGiovanniTerrace.
Howtoreachthemee;ngvenueFromLameziaTermeInterna;onalAirport:ittakesa35minutes-drivetoreachUniversitàMagnaGraeciafromLameziaTermeInterna'onalAirport(SUF).Fromtheairport,takeSS280towardsCatanzaro,proceedun'ltheexitforGermaneto,andcon'nueontoVialeEuropa'lltheUniversityBuilding.Alterna'vely,takethebustoeitherGermaneto,CatanzaroorCatanzaroLido.SeveralbusservicesareavailablefromMondaytoSaturday:formoredetailson'metablesandfees,visith`ps://lameziaairport.it/traspor'/.Alocalpublicshu`leconnectstheairporttoLameziaTermeCentralerailwaysta'on.For'metables,visith`p://www.lameziamul'servizi.itFromLameziaTermeCentraleRailwaySta;on:takethetraintoeitherCatanzaroorCatanzaroLido.For'metables,visitwww.trenitalia.itFromCatanzaroRailwaySta;on:-bypublictransporta'on:takeeitheroneofthebusesU1/U2/U3/U4/U5towards«CAMPUS».Infoonwww.amcspa.it-bycar(15min):takeSS280towardsLameziaTerme,proceedun'ltheexitforGermaneto,andcon'nueontoVialeEuropa'ltheUniversityBuilding.FromCatanzaroLidoRailwaySta;on:-bypublictransporta'on:taketheU1bustowards«CAMPUS».Infoonwww.amcspa.it-bycar:takeStradaProvinciale48towardsCatanzaroun'ltheintersec'onwithVialeEuropa,proceedonVialeEuropaun'ltheUniversityBuildingFromSoverato(25min):taketheIonianhighway106northwardsuptotheintersec'onwithCatanzaroLido,takeaturntowardsLameziaTermeandcon'nueontoVialeEuropa.FromA3motorway(Salerno-ReggioCalabria):taketheexitforLameziaTerme/Catanzaro,proceedalongSS208towardsCatanzaroun'ltheexitforGermanetoandcon'nueontoVialeEuropa.
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Hotelaccommoda;onAffiliatedhotels:HotelPalace,ViaLungomare,221HotelNiagara,VialeCrotone,170
Themee'ngwillprovidescheduledshu`leservicesfortransfersbetweenaffiliatedhotelsandtheconferencevenue.Transportforthesocialeventwillbealsoguaranteed.
Underthepatronageof
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WiththeunrestrictedgrantofAICCsupporters
32ndAnnual Conference1International and
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