Obstructive and restrictive respiratory diseases

Lung volumes

• Total Lung Capacity (TLC) - the total volume of the lung, the volume of air contained in the lung at the end of maximal inspiration

• Inspiratory Reserve Volume (IRV) - volume, which can be inspired beyond a restful inspiration

• Tidal Volume (TV) – volume of a single breath, usually at rest• Functional Residual Capacity (FRC) - The amount of air left in the lungs

after a tidal breath out, the amount of air that stays in the lungs during normal breathing

• Vital Capacity (VC) – maximum volume which can be ventilated in a single breath

• Inspiratory Capacity (IC) - the maximal volume that can be inspired following a normal expiration

• Expiratory Reserve Volume (ERV) – volume, which can be expired beyond a restful expiration

• Residual Volume (RV) – volume remaining in the lungs after a maximum expiration

Volumes• Forced Vital Capacity (FVC) - the volume of air

that can forcibly be blown out after full inspiration, measured in litres

• Forced Expiratory Volume in 1 Second (FEV1) - the maximum volume of air that can forcibly blow out in the first second during the FVC manoeuvre, measured in liters

• FEV1/FVC (FEV1%) - in healthy adults this should be approximately 75–80%. In obstructive diseases (asthma, COPD, chronic bronchitis, emphysema) FEV1 is decreased because of increased airway resistance to expiratory flow and the FVC may be increased (for instance by air trapping in emphysema). FEV1/FVC is decreased (<80%, often ~45%). In restrictive diseases (such as pulmonary fibrosis) the FEV1 and FVC are both reduced proportionally and the FEV1/FVC value may be normal or even increased as a result of decreased lung compliance

Obstructive lung diseases

• airway obstruction• restricted expiration FEV1, FEV1/FVC compliance, elasticity

• Chronic bronchitis– Bronchiolitis

• Asthma• Emphysema• Bronchiectasia• Cystic fibrosis

Asthma

COPD

normal

Condition Major changes Causes Symptoms

Chronic Hyperplasia Tobacco smoking Productivebronchitis and hypersecretion and air pollutants cough of mucus glands

Bronchiectasis Dilation and scarring Persistent severe Cough, purulent of airways infections sputum and fever

Asthma Smooth muscle Immunologic Episodic wheezing hyperplasia or idiopathic cough and dyspnea Excessive mucus

Inflammation

Emphysema Airspace enlargement Tobacco smoking Dyspnea Genetic and wall destruction

Restrictive lung diseases

• restricted lung expansion• restricted inspiration + expiration FEV1, FVC, FEV1/FVC normal compliance, elasticity

• Interstitial diseases – pneumonia• Fibrosis of lungs – asbestosis,

silicosis• Restriction to breathing –

pneumothorax, malformities, fracturae

Signs• dyspnea• hypoxemia• cor pulmonale

Flow volume curves

Normal spirogram

Spirogram in obstruction

Spirogram in restriction

Asthma

• Chronic inflamatory disease of bronchi leading to spasmatic occlusion and hyperproduction of viscous mucus

Causes• allergic

– allergens– infection

• non-allergic– neurogenic– psychogenic

Asthma atack

• acute exacerbation of asthma

Signs and symptoms• dyspnea, wheezing, catching for air• cough – viscous sputum• cyanosis

• tachycardia• chest pain

Chronic bronchitis

• chronic inflammation of bronchi

Causes• smoking• air pollutions

Signs and symptoms• expectorating cough (productive cough, produces sputum)• dyspnea, wheezing• chest pain• fever• fatigue and malaise

Chronic bronchitis

Smoking• impairs ciliary movement• inhibits function of alveoli macrophages• hypertrophy and hyperplasia of mucus-secreting gland• causes smooth muscle constriction

Air pollutions• ozone• CO• SO2

EmphysemaAbnormal, permanent enlargement and destruction of theair spaces

distal to the terminal bronchioles withou obvious fibrosis, progressively lose elasticity and eventual rupture of alveoli

•Panacinar (or panlobular) emphysema: The entire respiratory acinus, from respiratory bronchiole to alveoli, is expanded. Occurs more commonly in the lower lobes, especially basal segments, and anterior margins of the lungs.Typical for alpha-1-antitrypsin deficiency. •Centroacinar (or centrilobular) emphysema: The respiratory bronchiole (proximal and central part of the acinus) is expanded. The distal acinus or alveoli are unchanged. Occurs more commonly in the upper lobes. Typical for smokers.

EmphysemaCauses• Inherited

– alpha 1-antitrypsin deficiency• Acquired

– cigarette smoking– air pollution

Signs and symptoms• Dyspnea upon exertion, wheezing, coughing• Pursed lips to maximize ventilation• Right heart failure• Hypoxia, respiratory acidosis

EmphysemaAlpha 1-antitrypsin deficiency (A1AD)

• inflammatory enzymes (such as elastase) destroy the alveolar tissue

• most A1AD patients do not develop clinically significant emphysema

• smoking and severely

decreased A1AT levels

(10-15%) can cause

emphysema at a young

age

Chronic obstructive pulmonary disease• combination of chronic brnchitis + emphysema + asthma

Cause• Smoking• Occupational exposures

– coal mining, gold mining, silicosis• Air pollution• Genetics

– alpha 1-antitrypsin deficiency• Other risk factors

– a tendency to sudden airway constriction in response to inhaled irritants (asthma)

– repeated lung infections• COPD as an autoimmune disease

– sustained inflammation mediated by autoantibodies and autoreactive T cells

Chronic obstructive pulmonary disease

Signs and symptoms• dyspnea, wheezing• mucous sputum• respiratory failure• cyanosis

• cor pulmonale• peripheral oedema (RV failure)• tachypnea