Contents

The Journal of Clinical InvestigationDecember 1985, Volume 76, Number 6

PerspectivesBiologically active atrial peptides. B. J. Ballermann andB. M. Brenner ....................

Regular ArticlesPhysiologic regulation of atrial natriuretic peptidereceptors in rat renal glomeruli. B. J. Ballermann, R. L.Hoover, M. J. Karnovsky, and B. M. Breiner.Cobalamin malabsorption in three siblings due to anabnormal intrinsic factor that is markedly susceptible toacid and proteolysis. Y. Yang, R. Ducos, A. J. Rosenberg,P. G. Catrou, J. S. Levine, E. R. Podell, and R. H. AllenAbsence ofgamma interferon and interleukin 2production during active visceral leishmaniasis. E. M.Carvalho, R. Badaro', S. G. Reed, T C. Jones, andW D. Johnson, Jr. ..................

Recognition of human insulin in vitro by T cells fromsubjects treated with animal insulins. L. J. Nell, V. J.Virta, and J. W Thomas.Human histocompatibility leukocyte antigen (HLA)haplotype frequencies estimated from the data on HLAclass I, II, and III antigens in 111 Japanese narcoleptics. K.Matsuki, T Juji, K. Tokunaga, T. Naohara, M. Satake,and Y. Honda ....................Self-perpetuating mechanisms of immunoglobulin Gaggregation in rheumatoid inflammation. J. Lunec, D. R.Blake, S. J. McCleary, S. Brailsford, and P. A. BaconGlucose transport and metabolism in adipocytes fromnewly diagnosed untreated insulin-dependent diabetics.Severely impaired basal and postinsulin binding activities.E. H]ollund, 0. Pedersen, B. Richelsen, H. Beck-Nielsen,and N. S.Sorensen.Ischemia induces partial loss of surface membrane polarityand accumulation of putative calcium ionophores. B. A.Molitoris, P. D. Wilson, R. W. Schrier, and F. R. SimonO6Alkylguanine-DNA alkyltransferase activity in humanmyeloid cells. S. L. Gerson, K. Miller, and N. A. BergerIsolation, characterization, and distribution of an unusualpancreatic human secretory protein. J. Gross, R. I.Carlson, A. W. Brauer, M. N. Margolies, A. L. Warshaw,and J. R. Wands ...................Formation of soluble immune complexes by complementin sera of patients with various hypocomplementemicstates. Difference between inhibition of immuneprecipitation and solubilization. J. A. Schifferli, G. Steiger,G. Hauptmann, P. J. Spaeth, and A. G. Sjoholm . . . . .

Monoclonal antibodies to T-2 toxin. In vitroneutralization of protein synthesis inhibition andprotection of rats against lethal toxemia. G. Feuerstein,J. A. Powell, A. T. Knower, andK W Hunter, Jr.

Analysis of helper activity on pokeweed mitogen- andinterleukin 2-driven immunoglobulin synthesis by

2041 neoplastic T4+ cells. F. Miedema, J. W. van Oostveen,F. G. Terpstra, A. W L. van den Wall Bake, R. Willemze,E. A. J. Rauws, R. Bieger, M. B. van't Veer, D. Catovsky,and C. J. M. Melief .Biosynthesis of the transferrin receptor in rabbit

2049 reticulocytes. T M. Cox, M. W. O'Donnell, P. Aisen, andI. M. London.A relationship between ultrasonic integrated backscatterand myocardial contractile function. S. A. Wickline, L. J.

2057 Thomas III, J. G. Miller, B. E. Sobel, and J. E. PerezAn intragenic deletion of the Factor IX gene in a familywith hemophilia B. S.-H. Chen, S. Yoshitake, P. F.Chance, G. L. Bray, A. R. Thompson, C. R. Scott, and K

2066 Kurachi.Dietary intake of sodium chloride in the rat influences[3H]nitrendipine binding to adrenal glomerulosa cell

2070 membranes but does not alter binding to vascular smoothmuscle membranes. R. J. Schiebinger and K. Kontrimus

2078

Biochemical marker in familial amyloidoticpolyneuropathy, Portuguese type. Family studies on thetransthyretin (prealbumin)-methionine-30 variant.M. J. M. Saraiva, P. P. Costa, and D. S. Goodman .Thrombomodulin is present in human plasma and urine.H. Ishii and P. W.Majerus.

2084 DNA binding to human leukocytes. Evidence for areceptor-mediated association, internalization, anddegradation of DNA. R. M. Bennett, G. T. Gabor, andM. M. Merritt.

Lysosomal enzyme phosphorylation in human fibroblasts.2091 Kinetic parameters offer a biochemical rationale for two

distinct defects in the uridine diphospho-N-acetylglu-cosamine:lysosomal enzyme precursor N-

2097 acetylglucosamine-l-phosphotransferase. L. Lang, TTakahashi, J. Tang, and S. Kornfeld.

2106 Demonstration and partial characterization of theinterferon-gamma receptor on human mononuclearphagocytes. A. Celada, R. Allen, I. Esparza, P. W. Gray,and R. D. Schreiber .

2115 In vitro prostacyclin production by ovine uterine andsystemic arteries. Effects of angiotensin II. R. R. Magness,K Osei-Boaten, M. D. Mitchell, and C. R. RosenfeldRenal cortex taurine content regulates renal adaptiveresponse to altered dietary intake of sulfur amino acids.

2127 R. W Chesney, N. Gusowski, and S. Dabbagh . . . . . .

Effect of metabolic clearance rate and hepatic extraction ofinsulin on hepatic and peripheral contributions tohypoglycemia. Z. Chap, T Ishida, J. Chou, C. J. Hartley,

2134 R. M. Lewis, M. Entman, and J. B. Field.

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Thrombin stimulates the adherence of neutrophils tohuman endothelial cells in vitro. G. A. Zimmerman, T. M.McIntyre, and S. M. Prescott ... . . . . . . . . . . . . 2235

Nasal challenge with ragweed pollen in hay fever patients.Effect of immunotherapy. P. S. Creticos, N. F. Adkinson,Jr., A. Kagey-Sobotka, D. Proud, H. L. Meier,R. M. Naclerio, L. M. Lichtenstein, and P. S. Norman 2247

Estimation of bone turnover evaluated by 47Ca-kinetics.Efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, andurinary hydroxyproline excretion. P. Charles, J. W. Poser,L. Mosekilde, and F. T. Jensen ... . . . . . . . . . 2254Loss of high affinity cardiac beta adrenergic receptors indogs with heart failure. D. E. Vatner, S. F. Vatner, A. M.Fzpii, and C. J. Homcy ... . . . . . . . . . . . . . 2259Relative contribution of aortic and carotid baroreflexes toheart rate control in man during steady state and dynamicincreases in arterial pressure. D. W. Ferguson, F. M.Abboud, and A. L. Mark . . . . . . . . . . . . . . . 2265Erythrocyte echinocytosis in liver disease. Role ofabnormal plasma high density lipoproteins. J. S. Owen,D. J. C. Brown, D. S. Harry, N. McIntyre, G. H. Beaven,H. Isenberg, and W. B. Gratzer ... . . . . . . . . . 2275Effects of thromboxane synthase inhibition on vascularresponsiveness in the in vivo rat mesentery. E. K. Jackson 2286Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source oftriiodothyronine in rats. J. E. Silva and P. R. Larsen 2296

Insulin-mediated reduction of whole body proteinbreakdown. Dose-response effects on leucine metabolismin postabsorptive men. N. K. Fukagawa, K. L. Minaker,J. W. Row~e, M. N. Goodman, D. E. Matthews, D. M. Bier,and V. R. Young .... . . . . . . . . . . . . . . . 2306

1,25-dihydroxyvitamin D increases calmodulin binding tospecific proteins in the chick duodenal brush bordermembrane. D. D. Bikle and S. Munson . . . . . . . . . 2312

Human platelet Fc receptor for immunoglobulin G.Identification as a 40,000-molecular-weight membraneprotein shared by monocytes. S. I. Rosenfeld, R. J.

Loonei', J. P. Leddy, D. C. Phipps, G. N. Abraham, andC. L. Anderson . . . . . . . . . . . . . . . . . . . 2317

Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. G. R.Grotendorst, G. R. Martin, D. Pencev, J. Sodek, and A. K.Harvey .... . . .. . . . . . . . . . . . . . . . 2323

A unique elastase in human blood platelets. H. L. James,Y. T. Wachtfogel, P. L. James, M. Zimmerman, R. '

Colman, and A. B. Cohen . . . . . . . . . . . . . . . 2330

Network interactions in Schistosoma japonicum infection.Identification and characterization of a serologicallydistinct immunoregulatory auto-antiidiotypic antibodypopulation. G. R. Olds and T. F. Kresina . . . . . . . . 2338

Structural requirements for parathyroid hormone action inmature bone. Effects on release of cyclic adenosinemonophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters. M. S.Calvo, M. J. Fryer, K. J. Laakso, R. A. Nissenson, P. A.Price, T. M. Murray, and H. Heath III . . . . . . . . . 2348

Insulin receptor biosynthesis in cultured lymphocytes frominsulin-resistant patients. J. A. Hedo, V. Y. Moncada, andS. I. Taylor .... . . . . . . . . . . . . . . . . . 2355

Oral administration of human serum immunoglobulin inimmunodeficient patients with viral gastroenteritis. Apharmacokinetic and functional analysis. G. A. Losonsky,J. P. Johnson, J. A. Winkelstein, and R. H. Yolken .Interaction of human monocytes, macrophages, andpolymorphonuclear leukocytes with zymosan in vitro.Role of type 3 complement receptors and macrophage-derived complement. R. A. B. Ezekowitz, R. B. Sim, G. G.MacPherson, and S. Gordon.Intracellular respiratory dysfunction and cell injury inshort-term anoxia of rabbit renal proximal tubules. T.Takano, S. P. Soltoff S. Murdaugh, and L. J. MandelDeficiency of the adhesive protein complex lymphocytefunction antigen 1, complement receptor type 3,glycoprotein p150,95 in a girl with recurrent bacterialinfections. Effects on phagocytic cells and lymphocytefunctions. A. Fischer, R. Seger, A. Durandy, B. Grospierre,J. L. Virelizier, F. Le Deist, C. Griscelli, E. Fischer, M.Kazatchkine, M.-C. Bohler, B. Descamps-Latscha, P. H.Trung, T. A. Springer, D. Olive, and C. Mawas.In vivo and in vitro studies on formation of bile acids inpatients with Zellweger syndrome. Evidence thatperoxisomes are of importance in the normal biosynthesisof both cholic and chenodeoxycholic acid. B. F. Kase, J. I.Pedersen, B. Strandvik, and I. Bjorkhem.Irreversible bone loss in osteomalacia. Comparison ofradial photon absorptiometry with iliac bonehistomorphometry during treatment. A. M. Parfitt, D. S.Rao, J. Stanciu, A. R. Villanueva, M. Kleerekoper, and B.Frame .

Rapid PublicationsAtriopeptin III. A potent natriuretic, diuretic, andhypotensive agent in rats with chronic renal failure. B. R.Cole, M. A. Kuhnline, and P. Needleman.Z-Nucleotide accumulation in erythrocytes from Lesch-Nyhan patients. Y Sidi and B. S. Mitchell.Serum vitamin D-binding protein is a third member of thealbumin and alpha fetoprotein gene family. N. E. Cookeand E. V.David.Beta-2 microglobulin is an amyloidogenic protein in man.P. D. Gorevic, T T Casey, W. J. Stone, C. R.DiRaimondo, F. C. Prelli, and B. Frangione .Stimulation of porcine jejunal ion secretion in vivo byprotein kinase-C activators. C. S. Weikel, J. J. Sando, andR. L. Guerrant ....................Sn-protoporphyrin suppresses chemically inducedexperimental hepatic porphyria. Potential clinicalimplications. R. A. Galbraith, G. S. Drummond, and A.Kappas.Tissue factor induction in human monocytes. Two distinctmechanisms displayed by different alloantigen-responsiveT cell clones. S. A. Gregory and T. S. Edgington .Metabolism and effects on platelet function of the purifiedeicosapentaenoic and docosahexaenoic acids in humans.C. von Schacky and P. C. Weber.Correction.December AuthorIndex.Author Index to Volume 76 .

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Contents

The Journal of Clinical InvestigationJuly 1985, Volume 76, Number I

PerspectivesVitamin D-endocrine system. N. H. Bell .........

Regular ArticlesProstacyclin production by the deendothelialized rabbitaorta. J. M. Boeynaems, N. Galand, and P. KetelbantMeasurement of regional neuronal removal ofnorepinephrine in man. D. S. Goldstein, R. Zimlichman,R. Stull, J. Folio, P. D. Levinson, H. R. Keiser, and I. J.Kopin.Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport systemin rat adipocytes. W. T. Garvey, J. M. Olefsky, and S.Marshall.Role of the kidneys in the metabolism of plasmamevalonate. Studies in humans and in rhesus monkeys.D. J. McNamara, E. H. Ahrens, Jr., T. S. Parker, and K.Morrissey .

Antigenic characterization of human hepatocellularcarcinoma. Development of in vitro and in vivoimmunoassays that use monoclonal antibodies. R. I.Carlson, E. Ben-Porath, D. Shouval, W. Strauss, K. J.Isselbacher, and J. R. Wands.Immunogens consisting of oligosaccharides from thecapsule of Haemophilus influenzae type b coupled todiphtheria toxoid or the toxin protein CRM 197. P.Anderson, M. E. Pichichero, and R. A. Insel.Differentiation and activation phenotypes of lung Tlymphocytes differ from those of circulating Tlymphocytes. B. L. Davidson, J. Faust, S. Pessano, R. P.Daniele, and G. Rovera.Hamster female protein, a sex-limited pentraxin, is aconstituent of Syrian hamster amyloid. J. E. Coe andM. J. Ross ..... 'Molecular analysis of the bare lymphocyte syndrome.K. E. Sullivan, J. D. Stobo, and B. M. Peterlin .Resistance of human tumor cells in vitro to oxidativecytolysis. J. O'Donnell-Tormey, C. J. DeBoer, and C. F.Nathan.Influence of a 60-hour fast on insulin-mediated splanchnicand peripheral glucose metabolism in humans. 0.Bjorkman and L. S. Eriksson .Binding of diamine oxidase activity to rat and guinea pigmicrovascular endothelial cells. Comparisons withlipoprotein lipase binding. A. Robinson- White, S. B.Baylin, T. Olivecrona, and M. A. Beaven.

A new murine monoclonal antibody reports an activation-dependent change in the conformation and/ormicroenvironment of the platelet glycoprotein IIb/IIIacomplex. B. S. Coller .................Increased insulin sensitivity and responsiveness of glucosemetabolism in adipocytes from female versus male rats. M.Guerre-Millo, A. Leturque, J. Girard, and M. Lavau

Human Factor VIII procoagulant protein. MonoclonalI antibodies define precursor-product relationships and

functional epitopes. C. A. Fulcher, J. R. Roberts, L. Z.Holland, and T. S. Zimmerman.Expression of class II transplantation antigen on vascular

7 smooth muscle cells in human atherosclerosis. L.Jonasson, J. Holm, 0. Skalli, G. Gabbiani, and G. K.Hansson.Control of sodium and potassium transport in the cortical

15 collecting duct of the rat. Effects of bradykinin,vasopressin, and deoxycorticosterone. K. Tomita, J. J.Pisano, and M. A. Knepper .Platelet-derived growth factor enhances in vitro

22 erythropoiesis via stimulation of mesenchymal cells. F.Delwiche, E. Raines, J. Powell, R. Ross, and J. AdamsonHuman fibronectin metabolism. B. A. Pussell, P. W.Peake, M. A. Brown, and J. A. Charlesworth .

31 Effects of insulin on peripheral and splanchnic glucosemetabolism in noninsulin-dependent (type II) diabetesmellitus. R. A. DeFronzo, R. Gunnarsson, 0. Bjorkman,M. Olsson, and J. Wahren.Evidence for the presence of xenopsin-related peptide(s) in

40 the gastric mucosa of mammals. G. E. Feurle, R. E.Carraway, E. Rix, and W. Knauf.Plasma immunoreactive gamma melanotropin in patientswith idiopathic hyperaldosteronism, aldosterone-producing

52 adenomas, and essential hypertension. G. T. Griffing, B.Berelowitz, M. Hudson, R. Salzman, J. A. E. Manson, S.Aurrechia, J. C. Melby, R. C. Pedersen, and A. C. BrownieModulation of renal sodium-potassium-adenosine

60 triphosphatase by aldosterone. Effect of high physiologiclevels on enzyme activity in isolated rat and rabbit tubules.S. K. Mujais, M. A. Chekal, W. J. Jones, J. P. Hayslett,

66 and A. I. Katz .

Androgen receptors influence the production of pulmonary75 surfactant in the testicular feminization mouse fetus. H. C.Nielsen.Autoantibody to the C3b/C4b receptor and absence of this

80 receptor from erythrocytes of a patient with systemic lupuserythematosus. J. G. Wilson, R. M. Jack, W. W. Wong,P. H. Schur, and D. T Fearon.

87 Influx of kininogens into nasal secretions after antigenchallenge of allergic individuals. C. R. Baumgarten, A. G.Togias, R. M. Naclerio, L. M. Lichtenstein, P. S. Norman,and D.Proud.

93 Cationization of catalase, peroxidase, and superoxidedismutase. Effect of improved intraarticular retention onexperimental arthritis in mice. J. Schalkwijk, W. B. vanden Berg, L. B. A. van de Putte, L. A. B. Joosten, and L.

In van den Bersselaar ..................lVI

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Oxygen-independent intracellular and oxygen-dependentextracellular killing of Escherichia coli S15 by humanpolymorphonuclear leukocytes. J. Weiss, L. Kao, M.Victor, and P. Elsbach .

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Cobalamin inactivation decreases purine and methioninesynthesis in cultured lymphoblasts. G. R. Boss ......Human alveolar macrophages produce a fibroblast-likecollagenase and collagenase inhibitor. H. G. Welgus, E. J.Campbell, Z. Bar-Shavit, R. M. Senior, and S. L.Teitelbaum.Immune complex hyperlipidemia induced by anapolipoprotein-reactive immunoglobulin A paraproteinfrom a patient with multiple myeloma. Characterization ofthis immunoglobulin. L. L. Kilgore, B. W. Patterson,D. M. Parenti, and W. R. Fisher ............Inhibition and subsequent enhancement of plateletresponsiveness by prostacyclin in the rabbit. Relationshipto platelet adenosine 3,5-cyclic monophosphate. M.Vanderwel and R. J.Haslam.

Pretreatment cytokinetics in acute myelogenous leukemia.213 Age-related prognostic implications. H. M. Kantarjian, B.

Barlogie, M. J. Keating, R. R. Hall, T. L. Smith, K. B.McCredie, and E. J. Freireich ........ . .. . . 319Increased amounts of a novel penicillin-binding protein in

219 a strain of methicillin-resistant Staphylococcus aureusexposed to nafcillin. H. F. Chambers, B. J. Hartman, andA.Tomasz...... 325

225

233Rat lung fibroblast collagen metabolism in bleomycin-induced pulmonary fibrosis. S. H. Phan, J. Varani, and D.Smith ...... .. . . . . . . .. . . . . . . . . 241Discordance between surface and cytoplasmic expression ofthe Leu-4 (T3) antigen in thymocytes and in blast cellsfrom childhood T lymphoblastic malignancies. M. P. Link,S. J. Stewart, R. A. Warnke, and R. Levy.Human dermal fibroblasts present tetanus toxoid antigento antigen-specific T cell clones. D. T. Umetsu, J. S. Pober,H. H. Jabara, W. Fiers, E. J. Yunis, S. J. Burakoff; C. S.Reiss, and R. S.Geha.Effects of plasmin on von Willebrand factor multimers.Degradation in vitro and stimulation of release in vivo.K K Hamilton, L. J. Fretto, D. S. Grierson, and P. A.McKee.Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine,bradykinin, and adenosine triphosphate. T M. McIntyre,G. A. Zimmerman, K Satoh, and S. M. Prescott.In vivo externalization of phosphatidylserine andphosphatidylethanolamine in the membrane bilayer andhypercoagulability by the lipid peroxidation of erythrocytesin rats. S. K Jain ...................Detection of cross-reactive anti-DNA antibody idiotypes onrenal tissue-bound immunoglobulins from lupus patients.D. A. Isenberg and C. Collins .Effect of hydrogen peroxide on prostaglandin productionand cellular integrity in cultured porcine aortic endothelialcells. A. R. Whorton, M. E. Montgomery, and R. S. KentAn adenosine triphosphate-dependent calcium uptakepump in human neutrophil lysosomes. M. S. KlempnerIsolation and characterization of a colonic autoantigenspecifically recognized by colon tissue-boundimmunoglobulin G from idiopathic ulcerative colitis. F.Takahashi and K M.Das.

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Studies of the pathogenesis of angioimmunoblasticlymphadenopathy. M. Honda, H. R. Smith, and A. D.Steinberg.Identification of the lymphokine soluble immune responsesuppressor in urine of nephrotic children. H. W. Schnaperand T. M. Aune ....................Carboxyterminal peptide fragments of the beta subunit areurinary products of the metabolism of desialylated humanchoriogonadotropin. S. Amr, C. Rosa, S. Birken, R.Canfield, and B.Nisula.Effect of insulin on the distribution and disposition ofglucose in man. E. Ferrannini, J. D. Smith, C. Cobelli, G.Toffiolo, A. Pilo, and R. A. DeFronzo.Rapid PublicationsIn vivo differentiation of blast-phase chronic granulocyticleukemia. Expression of c-myc and c-abl protooncogenes.C. A. Koller, V W Campbell, D. A. Polansky, A. Mulhern,and D. M.Miller.Evidence for alteration of the vitamin D-endocrine systemin obese subjects. N. H. Bell, S. Epstein, A. Greene, J.Shary, M. J. Oexmann, and S.Shaw.Leukotriene C4 binds to human glomerular epithelial cellsand promotes their proliferation in vitro. L. Baud, J.Sraer, J. Perez, M.-P. Nivez, and R. Ardaillou.

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374Posttranslational cleavage of proinsulin is blocked by apoint mutation in familial hyperproinsulinemia. Y.Shibasaki, T. Kawakami, Y. Kanazawa, Y. Akanuma, andF. Takaku ...... . . . . . . . . . . . . . . . . 378A defect in the regulation of major histocompatibilitycomplex class II gene expression in human HLA-DRnegative lymphocytes from patients with combinedimmunodeficiency syndrome. B. Lisowska-Grospierre,D. J. Charron, C. de Preval, A. Durandy, C. Griscelli, andB. Mach . . . . . . . . . . . . . . . . . . . . . . . 381Correction ...... . . . . . . . . . . . . . . . . 387July Author Index . . . . . . . . . . . . . . . . . . . 389

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The Journal of Clinical InvestigationAugust 1985, Volume 76, Number 2

PerspectivesTumor products and the hypercalcemia of malignancy.G. R. Mundy, K. J. Ibbotson, and S. M. D'Souza .

Regular ArticlesSecretion of an articular cartilage proteoglycan-degradingenzyme activity by murine T lymphocytes in vitro. G. M.Kammer, A. I. Sapolsky, and C. J. Malemud.Apolipoprotein B-100 deficiency. Intestinal steatosis despiteapolipoprotein B-48 synthesis. P. N. Herbert, J. S. Hyams,D. N. Bernier, M. M. Berman, A. L. Saritelli, K M.Lynch, A. V. Nichols, and T. M. Forte .........Activation of Factor XII-dependent pathways in humanplasma by hematin and protoporphyrin. C. G. Becker, M.Wagner, A. P. Kaplan, M. Silverberg, R. W. Grady, H.Liem, and U. Muller-Eberhard .............Pathophysiology of spontaneous hypercalciuria inlaboratory rats. Role of deranged vitamin D metabolism.K Lau, D. Thomas, C. Langman, and B. Eby .Evidence for a mouse mesangial cell-derived factor thatstimulates lymphocyte proliferation. E. P. MacCarthy, A.Hsu, Y. M. Ooi, and B. S.Ooi.Phorbol diesters stimulate the development of an earlymurine progenitor cell. The burst-forming unit-megakaryocyte. M. W. Long, L. L. Gragowski, C. H.Heffner, and L. A. Boxer .Identification of gallbladder mucin-bilirubin complex inhuman cholesterol gallstone matrix. Effects of reducingagents on in vitro dissolution of matrix and intactgallstones. B. F. Smith and J. T. LaMont.Interleukin-2 receptor (Tac antigen) expressed on adult Tcell leukemia cells. T. Uchiyama, T. Hori, M. Tsudo, Y.Wano, H. Umadome, S. Tamori, J. Yodoi, M. Maeda, H.Sawami, and H. Uchino.Immunological studies of an organic anion-binding proteinisolated from rat liver cell plasma membrane. A. W.Wolkoff A. Sosiak, H. C. Greenblatt, J. Van Renswoude,and R. J. Stockert.Regulation of glucose utilization in adipose cells andmuscle after long-term experimental hyperinsulinemia inrats. L. J. Wardzala, M. Hirshman, E. Pofcher, E. D.Horton, P. M. Mead, S. W. Cushman, and E. S. HortonEvidence for alteration of the vitamin D-endocrine systemin blacks. N. H. Bell, A. Greene, S. Epstein, M. J.Oexmann, S. Shaw, and J. Shary.Evidence for beta adrenoceptors in proximal tubules.Isoproterenol-sensitive adenylate cyclase in pars recta ofcanine nephron. N. Murayama, B. T. Ruggles, S. M.Gapstur, J. L. Werness, and T. P. Dousa ........Characterization of a new model of GM2-gangliosidosis(Sandhoff's disease) in Korat cats. E. A. Neuwelt, W. G.Johnson, N. K. Blank, M. A. Pagel, C. Maslen-McClure,M. J. McClure, and P. M. Wu.Interaction of human leukocytes and Entamoebahistolytica. Killing of virulent amebae by the activatedmacrophage. R. A. Salata, R. D. Pearson, and J. I. Ravdin

Immunoglobulin G-induced single ionic channels inhuman alveolar macrophage membranes. D. J. Nelson,

391 E. R. Jacobs, J. M. Tang, J. M. Zeller, and R. C. BoneVirulence of Cryptococcus neoformans. Regulation ofcapsule synthesis by carbon dioxide. D. L. Granger, J. R.Perfect, and D. T.Durack.Systemic complement activation, lung injury, and products

395 of lipid peroxidation. P. A. Ward, G. 0. Till, J. R.Hatherill, T. M. Annesley, and R. G. Kunkel .

Identification of intracellular Factor XIII in humanmonocytes and macrophages. P. Henriksson, S. Becker, G.

403 Lynch, and J.McDonagh.Antiadhesive properties of biological surfaces are protectiveagainst stimulated granulocytes. J. Fehr, R. Moser, D.Leppert, and P. Groscurth.

413 Paradoxical effects of pyrazinoate and nicotinate on uratetransport in dog renal microvillus membranes. S. E.

420 Guggino and P. S. Aronson .Regulatory roles of Tjt and T-y cells in the collaborativecellular initiation of the extrinsic coagulation pathway bybacterial lipopolysaccharide. G. A. Levy, B. S. Schwartz,

426 L. K. Curtiss, and T. S. Edgington.Excess purine degradation in exercising muscles of patientswith glycogen storage disease types V and VII. I. Mineo,N. Kono, T. Shimizu, N. Hara, Y. Yamada, S. Sumi, K

431 Nonaka, and S. Tarui.

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In vivo and in vitro studies of urinary concentrating abilityin potassium-depleted rabbits. K. H. Raymond, K. K.Davidson, and T. D. McKinney ..............Hydrogen peroxide from cellular metabolism of cystine. Arequirement for lysis of murine tumor cells by vernolepin,a glutathione-depleting antineoplastic. B. A. Arrick, W.Griffo, Z. Cohn, and C. Nathan........... . .

Development of an integrated model for analysis of thekinetics of apolipoprotein B in plasma very low densitylipoproteins, intermediate density lipoproteins, and lowdensity lipoproteins. W. F. Beltz, Y. A. Kesaniemi, B. V.Howard, and S. M.Grundy.Comparisons of metabolism of apolipoprotein B in normalsubjects, obese patients, and patients with coronary heartdisease. Y. A. Kesaniemi, W. F. Beltz, and S. M. Grundy

460 Influence of obesity on the metabolism of apolipoprotein Bin humans. G. Egusa, W. F. Beltz, S. M. Grundy, andB. Vi Howard.

470 Diminished type I collagen synthesis and reduced alphal(I) collagen messenger RNA in cultured fibroblasts frompatients with dominantly inherited (type I) osteogenesisimperfecta. D. W Rowe, J. R. Shapiro, M. Poirier, and S.

474 Schlesinger.Control of glomerular hypertension limits glomerularinjury in rats with reduced renal mass. S. Anderson, T. W.Meyer, H. G. Rennke, and B. M. Brenner.

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491

Regional alveolar pressure during periodic flow. Dualmanifestations of gas inertia. J. L. Allen, I. D. Frantz III,and J. J. Fredberg .

500

508

517

528

535

543

548

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561

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Modulation of phosphate absorption by calcium in therabbit proximal convoluted tubule. D. Rouse andW N. Suki......................Multiple disturbances of free fatty acid metabolism innoninsulin-dependent diabetes. Effect of oral hypoglycemictherapy. M.-R. Taskinen, C. Bogardus, A. Kennedy, andB. V. Howard .....................Induction of the insulin proreceptor by hydrocortisone incultured lymphocytes (IM-9 line). D. G. Rouiller, A.McElduff; J. A. Hedo, and P. Gorden.Accumulation of leukotriene C4 and histamine in humanallergic skin reactions. S. F. Talbot, P. C. Atkins, E. J.Goetzl, and B. Zweiman.Effects of exercise training on in vivo insulin action inindividual tissues of the rat. D. E. James, E. W. Kraegen,and D. J. Chisholm.Pathophysiology of chronic tubulo-interstitial disease inrats. Interactions of dietary acid load, ammonia, andcomplement component C3. K. A. Nath, M. K. Hostetter,and T. H. Hostetter ..................

Biliary secretion of fluid-phase markers by the isolatedperfused rat liver. Role of transcellular vesicular transport.J. R. Lake, V. Licko, R. W. Van Dyke, and B. F.Scharschmidt.Distinct clonotypes of anti-DNA antibodies in mice withlupus nephritis. H. Yoshida, M. Yoshida, S. Izui, andP. H. Lambert ....................Long-term control of plasma calcitriol concentration indogs and humans. Dominant role of plasma calciumconcentration in experimental hyperparathyroidism. H. N.Hulter, B. P. Halloran, R. D. Toto, and J. C. PetersonN-Acetylcysteine potentiates inhibition of plateletaggregation by nitroglycerin. J. Loscalzo .........Clonal analysis of T lymphocytes in the acquiredimmunodeficiency syndrome. Evidence for an abnormalityaffecting individual helper and suppressor T cells. J. B.Margolick, D. J. Volkman, H. C. Lane, and A. S. FauciLocalization of collagenase in the growth plate of rachiticrats. D. D. Dean, 0. E. Muniz, I. Berman, J. C. Pita,M. R. Carreno, J. F. Woessner, Jr., and D. S. HowellAnti-Fab antibodies in humans. Predominance of minorimmunoglobulin G subclasses in rheumatoid arthritis. J. E.Persselin and R. H. Stevens.Familial systemic lupus erythematosus. Presence of a cross-reactive idiotype in healthy family members. R. Halpern,A. Davidson, A. Lazo, G. Solomon, R. Lahita, andB. Diamond .....................Effect of dietary fat, carbohydrate, and protein onbranched-chain amino acid catabolism during caloricrestriction. J. A. Vazquez, E. L. Morse, and S. A. AdibiBiosynthesis of bile acids in cerebrotendinousxanthomatosis. Relationship of bile acid pool sizes andsynthesis rates to hydroxylations at C-12, C-25, and C-26.G. Salen, S. Shefer, G. S. Tint, G. Nicolau, B. Dayal, andA. K. Batta ......................Markedly increased circulating pyridoxal-5 -phosphatelevels in hypophosphatasia. Alkaline phosphatase acts invitamin B6 metabolism. M. P. Whyte, J. D. Mahuren,L. A. Vrabel, and S. P. Coburn.Substrate cycling between gluconeogenesis and glycolysis ineuthyroid, hypothyroid, and hyperthyroid man. G. I.Shulman, P. W. Ladenson, M. H. Wolfe, E. C. Ridgway,and R. R. Wolfe .

Cytoplasmic immunoglobulin content in multiplemyeloma. B. Barlogie, R. Alexanian, M. Pershouse, L.Smallwood, and L. Smith .............

Effect of arginine vasopressin on renal medullary bloodflow. A videomicroscopic study in the rat. B.

630 Zimmerhackl, C. R. Robertson, and R. L. Jamison .

637

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Importance of amino acids on vasopressin-stimulated waterflow. C. P. Carvounis, G. Carvounis, and B. J. WilkIdentification of immunostimulatory dendritic cells in thesynovial effusions of patients with rheumatoid arthritis.N. J. Zvaifler, R. M. Steinman, G. Kaplan, L. L. Lau, andM. Rivelis ......................Immunologic and structural studies of the lupus/Sjogren'ssyndrome autoantigen, La/SSB, with a monoclonalantibody. J. B. Harley, M. 0. Rosario, H. Yamagata,0. F. Fox, and E. Koren .Enhancement of the impaired autologous mixed leukocytereaction in patients with systemic lupus erythematosus.

657 M. K. Crow......................Effect of Reye's syndrome serum on isolated chinchillaliver mitochondria. J. H. Tonsgard and G. S. Getz .

667oElevated Factor Xa activity in the blood of asymptomatic667patients with congenital antithrombin deficiency. K. A.

Bauer, T. L. Goodman, B. L. Kass, and R. D. RosenbergInfluences of gamma interferon on synovial fibroblastlikecells. Ia induction and inhibition of collagen synthesis.

676 E. P. Amento, A. K. Bhan, K G. McCullagh, and S. M.Krane.Serial studies of autologous antibody reactivity to

685 ....melanoma. Relationship to clinical course and circulatingimmune complexes. D. R. Vlock and J. M. KirkwoodContribution of individual superficial nephron segments toammonium handling in chronic metabolic acidosis in the

695 ....rat. Evidence for ammonia disequilibrium in the renalcortex. E. Simon, D. Martin, and J. Buerkert.

703 Acute intermittent porphyria: characterization of a novelmutation in the structural gene for porphobilinogendeaminase. Demonstration of noncatalytic enzymeintermediates stabilized by bound substrate. R. J. Desnick,

709 L. T. Ostasiewicz, P. A. Tishler, and P. Mustajoki .

Rapid Publications

716 Thermal inactivation of the acquired immunodeficiencysyndrome virus, human T lymphotropic virus-III/lymphadenopathy-associated virus, with special reference

723 to antihemophilic factor. J. S. McDougal, L. S. Martin,3 S. P. Cort, M. Mozen, C. M. Heldebrant, and B. L. Evatt

731

737

L6 cells as a tissue culture model for thyroid hormoneeffects on skeletal muscle metabolism. R. J. Koenig andR. J. Smith ......................Muscarinic receptors on intact human fibroblasts. Absenceof receptor activity in adult skin cells. D. A. Van Riper,M. P. Absher, and R. H. Lenox .

Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram ofdiabetic rats. L. C. MacGregor and F. M. MatschinskyMetabolic effect of 3,3',5'-triiodothyronine in cultured

744 growth hormone-producing rat pituitary tumor cells.Evidence for a unique mechanism of thyroid hormoneaction. D. L. St. Germain.Identification of a point mutation in the adenosine

752 deaminase gene responsible for immunodeficiency. D. T.Bonthron, A. F. Markham, D. Ginsburg, and S. H. Orkin

757

765

Thromboxane synthase is preferentially conserved inactivated mouse peritoneal macrophages. C. S. Tripp,K. M. Leahy, and P. Needleman.

CCorrection... .multipleAugust AuthorIndex.

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Contents

The Journal of Clinical InvestigationSeptember 1985, Volume 76, Number 3

PerspectivesPolyglutamation of methotrexate. Is methotrexate aprodrug? B. A. Chabner, C. J. Allegra, G. A. Curt, N. J.Clendeninn, J. Baram, S. Koizumi, J. C. Drake, andJ. Jolivet .......................

Regular ArticlesDiscordance between transferrin receptor expression andsusceptibility to lysis by natural killer cells. K. R. Bridgesand B. R.Smith.Effects of dichloroacetate in the treatment of hypoxic lacticacidosis in dogs. H. Graf, W. Leach, and A. I. Arieff . . . .

Differential effect of hydrocortisone on eosinophil andneutrophil proliferation. B. H. Bjornson, J. M. Harvey, andL.Rose....

Inhibitory role of dietary protein restriction on thedevelopment and expression of immune-mediatedantitubular basement membrane-induced tubulointerstitialnephritis in rats. D. Agus, R. Mann, D. Cohn, L. Michaud,C. Kelly, M. Clayman, and E. G. Neilson .

Monoclonal anti-human Factor VII antibodies. Detectionin plasma of a second protein antigenically and geneticallyrelated to Factor VII. G. J. Broze, Jr., S. Hickman, andJ. P. Miletich .....................Characteristics of thyroxine 5'-deiodination in culturedhuman placental cells. Regulation by iodothyronines. J. T.Hidal and M. M. Kaplan .

Oxygen radical-induced erythrocyte hemolysis byneutrophils. Critical role of iron and lactoferrin. G. M.Vercellotti, B. S. van Asbeck, and H. S. Jacob .Catalytic defect of medium-chain acyl-coenzyme Adehydrogenase deficiency. Lack of both cofactorresponsiveness and biochemical heterogeneity in eightpatients. B. A. Amendt and W. J. Rhead . . . . . . . . .

Antigen-induced monocyte procoagulant activity.Requirement for antigen presentation andhistocompatibility leukocyte antigen-DR molecules. B. S.Schwartz.Bradykinin-induced changes in phosphatidyl inositolturnover in cultured rabbit papillary collecting tubule cells.J. A. Shayman and A. R. Morrison.Pretranslational regulation of the synthesis of the thirdcomponent of complement in human mononuclearphagocytes by the lipid A portion of lipopolysaccharide.R. C. Strunk, A. S. Whitehead, and F. S. Cole.Human peripheral blood monocytes display surfaceantigens recognized by monoclonal antinuclear antibodies.V. M. Holers and B. L. Kotzin.Effect of prostacyclin on vascular capacity in the dog. T. G.Fulghum, J. P. DiMarco, E. W. Supple, I. Nash,J. Gendlerman, D. F. Eton, J. B. Newell, R. M. Zusman,and W J. Powell, Jr...................

Intraairway thermal profiles during exercise andhyperventilation in normal man. E. R. McFadden, Jr., andB. M. Pichurko .................... 1007Functional significance of renal prostacyclin and

907 thromboxane A2 production in patients with systemic lupuserythematosus. C. Patrono, G. Ciabattoni, G. Remuzzi,E. Gotti, S. Bombardieri, 0. Di Munno, G. Tartarelli, G. A.Cinotti, B. M. Simonetti, and A. Pierucci . . . . . . . . . 1011Effects of dietary fat on postprandial substrate oxidation

913 and on carbohydrate and fat balances. J. P. Flatt, E.Ravussin, K. J. Acheson, and E. Jeiquier . . . . . . . . . 1019

919 Role of renal metabolism and excretion in 5-nitrofuran-induced uroepithelial cancer in the rat. L. A. Spry, T. V.Zenser, S. M. Cohen, and B. B. Davis .... . . . . . . 1025

924 Inhibitory effect of a human T cell hybrid factor on bothcell growth and mixed lymphocyte reactivity. Correlationwith class II molecule expression. M. Trucco, S. Shaw, andR. Korngold ...... . . . . . . . . . . . . . . . . 1032Role of the thymus in streptococcal cell wall-induced

930 arthritis and hepatic granuloma formation. Comparativestudies of pathology and cell wall distribution in athymicand euthynlic rats. J. B. Allen, D. G. Malone, S. M. Wahl,G. B. Calandra, and R. L. Wilder .... . . . . . . . . 1042

937 Compensatory increase in a 1 -globin gene expression inindividuals heterozygous for the a-thalassemia-2 deletion.S. A. Liebhaber, F. E. Cash, and D. M. Main .

947 Renal adaptation to potassium in the adrenalectomizedrabbit. Role of distal tubular sodium-potassium adenosinetriphosphatase. L. C. Garg and N. Narang.

. 1057

. 1065956 Inhibition of vasopressin-stimulated water flow in toad

bladder by phorbol myristate acetate, dioctanoylglycerol,and RHC-80267. Evidence for modulation of action ofvasopressin by protein kinase C. D. Schlondorffand

963 S. D. Levine . . . . . . . . . . . . . . . . . . . . . . 1071Intracellular pH modulates the generation of superoxideradicals by human neutrophils. L. Simchowitz . . . . . . 1079Deoxyribonucleic acid polymorphism in the apolipoprotein

970 A- 1-C-Ill gene cluster. Association withhypertriglyceridemia. A. Rees, J. Stocks, C. R. Sharpe,M. A. Vella, C. C. Shoulders, J. Katz, N. I. Jowett, F. E.

978 Baralle, and D. J. Galton.1090Terbutaline-induced desensitization of human lymphocyte32-adrenoceptors. Accelerated restoration of (3-adrenoceptorresponsiveness by prednisone and ketotifen. O.-E. Brodde,

985 M. Brinkmann, R. Schemuth, N. O'Hara, and A. Daul

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Biosynthesis of von Willebrand protein by humanmegakaryocytes. L. A. Sporn, S. I. Chavin, V. J. Marder,and D. D. Wagner...Thermic effect of food at rest, during exercise, and afterexercise in lean and obese men of similar body weight.K. R. Segal, B. Gutin, A. M. Nyman, and F. X. Pi-Sunyer

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Receptor-independent low density lipoprotein transport inthe rat in vivo. Quantitation, characterization, andmetabolic consequences. D. K. Spady, S. D. Turley, andJ. M. Dietschy . . . . . . . . . . . . . . . . . . . . . 1113Bicarbonate secretion and chloride absorption by rabbitcortical collecting ducts. Role of chloride/bicarbonateexchange. R. A. Star, M. B. Burg, and M. A. Knepper . . . 1123Glutathione cycle activity and pyridine nucleotide levels inoxidant-induced injury of cells. I. U. Schraufstatter, D. B.Hinshaw, P. A. Hyslop, R. G. Spragg, and C. G. Cochrane 1131Thymoma epithelial cells secrete thymic hormone but donot express class II antigens of the major histocompatibilitycomplex. W. Savino, G. Manganefia, J.-M. Verley, A.Wolff, S. Berrih, P. Levasseur, J.-P. Binet, M. Dardenne,and J.-F. Bach . . . . . . . . . . . . . . . . . . . . 1140Blood pressure development of the spontaneouslyhypertensive rat after concurrent manipulations of dietaryCa2' and Na'. Relation to intestinal Ca2+ fluxes. D. A.McCarron, P. A. Lucas, R. J. Shneidrnan, B. LaCour, andT. Drueke . . . . . . . . . . . . . . . . . . . . . . . 1147Oxidants increase paracellular permeability in a culturedepithelial cell line. M. J. Welsh, D. M. Shasby, andR. M. Husted . . . . . . . . . . . . . . . . . . . . . 1155Hemoglobin Rahere, a human hemoglobin variant withamino acid substitution at the 2,3-diphosphoglyceratebinding site. Functional consequences of the alteration andeffects of bezafibrate on the oxygen bindings. J. Sugihara,T. Imamura, S. Nagafuchi, J. Bonaventura, C.Bonaventura, and R. Cashon . . . . . . . . . . . . . . 1169Effects of atropine and gastric inhibitory polypeptide onhepatic glucose uptake and insulin extraction in consciousdogs. Z. Chap, T Ishida, J. Chou, R. Lewis, C. Hartley,M. Entman, and J. B. Field . . . . . . . . . . . . . . . 1174

Experimental pulmonary inflammatory injury in themonkey. S. D. Revak, C. L. Rice, I. U. Schraufstatter,W. A. Halsey, Jr., B. P. Bohl, R. M. Clancy, and,C. G. Cochrane . . . . . . . . . . . . . . . . . . . . 1182Oxygen deprivation-induced injury to isolated rabbit kidneytubules. J. M. Weinberg . . . . . . . . . . . . . . . . 1193Hepatic and renal metabolism before and afterportasystemic shunts in patients with cirrhosis. 0. E. Owen,M. A. Mozzoli, F. A. Reichle, T. H. Kreulen, R. S. Owen,G. Boden, and M. Polansky . . . . . . . . . . . . . . . 1209Leukotriene B4 w-hydroxylase in humanpolymorphonuclear leukocytes. Partial purification andidentification as a cytochrome P-450. S. Shak andI. M. Goldstein .....................

Mechanism of liver glycogen repletion in vivo by nuclearmagnetic resonance spectroscopy. G. I. Shulman, D. L.Rothman, D. Smith, C. M. Johnson, J. B. Blair, R. G.Shulman, and R. A. DeFronzo.Interactions of insulin, insulinlike growth Factor II, andplatelet-derived growth factor in erythropoietic culture.N. Dainiak and S.Kreczko.Identification of malignant plasma cell precursors in thebone marrow of multiple myeloma. F. Caligaris-Cappio,L. Bergui, L. Tesio, G. Pizzolo, F. Malavasi, M. Chilosi,D. Campana, B. van Camp, and G. Janossy.Studies on the in vivo and in vitro distribution ofapolipoprotein A-IV in human plasma and lymph. T. Ohta,N. H. Fidge, and P. J. Nestel.Characterization of immunotoxins active against ovariancancer cell lines. R. Pirker, D. J. P. FitzGerald, T. C.Hamilton, R. F. Ozols, W. Laird, A. E. Frankel, M. C.Willingham, and I.Pastan.Evidence that insulin resistance is responsible for thedecreased thermic effect of glucose in human obesity.E. Ravussin, K J. Acheson, 0. Vernet, E. Danforth, andE. Jequier ......................Rapid PublicationsAcquired Bernard-Soulier syndrome. Evidence for the roleof a 2 10,000-molecular weight protein in the interaction ofplatelets with von Willebrand factor. R. B. Stricker, D.Wong, S. R. Saks, L. Corash, and M. A. Shuman .

A human T cell clone that mediates the monocyteprocoagulant response to specific sensitizing antigen. B. S.Schwartz, P. J. Reitnauer, J. A. Hank, and P. M. SondelDetection of a frequent restriction fragment lengthpolymorphism in the human T cell antigen receptor betachain locus. A potential diagnostic tool. N. Berliner, A. D.Duby, C. C. Morton, P. Leder, and J. G. Seidman .

Purification of fetal hematopoietic progenitors anddemonstration of recombinant multipotential colony-stimulating activity. S. G. Emerson, C. A. Sieff E. A.Wang, G. G. Wong, S. C. Clark, and D. G. NathanSeptember AuthorIndex.

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Contents

The Journal of Clinical InvestigationOctober 1985, Volume 76, Number 4

Presidential Address.

Regular ArticlesPostnatal development of alveoli. Regulation and evidencefor a critical period in rats. D. Massaro, N. Teich, S.Maxwell, G. D. Massaro, and P. Whitney.Degradation of heparan sulfate in the subendothelialextracellular matrix by a readily released heparanase fromhuman neutrophils. Possible role in invasion throughbasement membranes. Y. Matzner, M. Bar-Ner, J.Yahalom, R. Ishai-Michaeli, Z. Fuks, and I. VlodavskyLow expression of human histocompatibility leukocyteantigen-DR is associated with hypermethylation of humanhistocompatibility leukocyte antigen-DRa gene regions inB cells from patients with systemic lupus erythematosus.H. Sano, L. J. Compton, N. Shiomi, A. D. Steinberg, R. A.Jackson, and T. Sasaki ...............Determinants of the sensitivity of human small-cell lungcancer cell lines to methotrexate. G. A. Curt. J. Jolivet,D. N. (arn'e. B. D. Bailev, J. C. Drake, N. J. C'lendeninn,and B. ..(iahnr. .. ................

Novel platelet-agglutinating protein from a thromboticthrombocytopenic purpura plasma. F. A. Siddiqui andE. C.-Y. Lian ....................Structural analysis of hepatitis B surface antigen bymonoclonal antibodies. E. Ben-Porath, J. R. Wands, R. A.Marciniak, M. A. Wong, L. Hornstein, R. Ryder, M.Canlas, A. Lingao, and K. J. Isselbacher.Chemotactic peptide activation of human neutrophils andHL-60 cells. Pertussis toxin reveals correlation betweeninositol trisphosphate generation, calcium ion transients,and cellular activation. K-H. Krause, W. Schlegel, C. B.Wollheim, T. Andersson, F. A. Waldvogel, and P. D. Lew

Glomerular arachidonate lipoxygenation in ratnephrotoxic serum nephritis. E. A. Lianos, M. A.Rahman, and M. J.Dunn.Active and passive components of chloride transport in therat proximal convoluted tubule. RB J. Alpern, K. J.Howlin, and P. A. Preisig.Macrophage-induced glomerular fibrin deposition inexperimental glomerulonephritis in the rabbit. S. R.Holdsworth and P. G. Tipping.Nasal challenge with cold, dry air results in release ofinflammatory mediators. Possible mast cell involvement.A. G. Togias, R. M. Naclerio, D. Proud, J. E. Fish, N. F.Adkinson, Jr., A. Kagey-Sobotka, P. S. Norman,-and L. M.Lichtenstein.Viral infection of vascular endothelial cells altersproduction of colony-stimulating activity. S. L. Gerson,H. M. Friedman, and D. B. Cines.

Definition of a possible genetic basis for susceptibility toacute myelogenous leukemia associated with the presenceof a polymorphic Ia epitope. S. Seremetis, J. Cuttner, andR. Winchester ....................

1293 Biochemical and clinical implications of proinsulinconversion intermediates. B. D. Given, R. M. Cohen, S. E.Shoelson, B. H. Frank, A. H. Rubenstein, and H. S. TagerAbnormal Factor VIII coagulant antigen in patients withrenal dysfunction and in those with disseminated

1297 intravascular coagulation. M. J. Weinstein, L. E. Chute,G. W. Schmitt, R. H. Hamburger, K. A. Bauer, J. H. Troll,P. Janson, and D.Deykin.Possible role of adenosine in the macula densa mechanismof renin release in rabbits. S. Itoh, 0. A. Carretero, and

1306 R. D. Murray.Monoclonal antibodies against complement 3 neoantigensfor detection of immune complexes and complementactivation. Relationship between immune complex levels,state of C3, and numbers of receptors for C3b. M. T.Aguado, J. D. Lambris, G. C. Tsokos, R. Burger, D. Bitter-

1314 Suermann, J. D. Tamerius, F. J. Dixon, and A. N.Theofilopoulos.Defensins. Natural peptide antibiotics of humanneutrophils. T Ganz, M. E. Selsted, D. Szklarek, S. S. L.

1323 Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer .

Primary structures of three human neutrophil defensins.M. E. Selsted, S. S. L. Harwig, T. Ganz, J. W. Schilling,

1330 and R. I. Lehrer.

Pathophysiology of protracted acute renal failure in man.S. M. Moran and B. D.Myers.Expression of complement proteins C2 and factor B in

1338 transfected L cells. D, H. Perlmutter, H. R. Colten, D.Grossberger, J. Strominger, J. G. Seidman, and D. D.Chaplin.Urine glycoprotein crystal growth inhibitors, Evidence for

1348 a molecular abnormality in calcium oxalatenephrolithiasis. Y. Nakagawa, V. Abram, J. H. Parks,H. S.-H. Lau, J. K. Kawooya, and F. L. Coe.Efficient clearance of non-transferrin-bound iron by ratliver. Implications for hepatic iron loading in ironoverload states. P. Brissot, T. L. Wright, W.-L. Ma, andR. A. Weisiger.

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Alterations in adenosine triphosphate and energy charge incultured endothelial and P388D, cells after oxidant injury.R. G. Spragg, D. B. Hinshaw, P. A. Hyslop, I. U.Schralfstatter, and C. G. Cochrane .

Allogeneic suppressive effects of pregnancy sera onmonocytes of responding cells in human mixedlymphocyte reactions. M. Nieda, T. Juji, and S. Imao

Central serotonergic stimulation of aldosterone secretion.Y. Shenker, M. D. Gross, and R. J. Grekin.Substructure of human von Willebrand factor. W. E.Fowler, L. J. Fretto, K. K. Hamilton, H. P. Erickson, andP. A. McKee........ . .. .

Apolipoprotein E associated with astrocytic glia of thecentral nervous system and with nonmyelinating glia of

1391 the peripheral nervous system. J. K. Boyles, R. E. Pitas, E.Wilson, R. W. Mahley, and J. M. Taylor.

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Bacillus Calmette-Gue'rin-stimulated neutrophils releasechemotaxins for monocytes in rabbit pleural spaces and invitro. V. B. Antony, S. A. Sahn, A. C. Antony, and J. E.Repine.vop Willebrand's disease with spontaneous plateletaggregation induced by an abnormal plasma vonWillebrand factor. H. R. Gralnick, S. B. Williams, L. P.McKeown, M. E. Rick, P. Maisonneuve, C. Jenneau, andY. Sultan ......................Effects of vasopressin antagonist on vasopressin binding,adenylate cyclase activation, and water flux. J. K Kim,M. A. Dillingham, S. N. Summer, S. Ishikawa, R. J.Anderson, and R. W. Schrier .

Aging decreases the capacity of human skin to producevitamin D3. J. MacLaughlin and M. F. Holick .A. circulating myocardial depressant substance in humanswith septic shock. Septic shock patients with a reducedejection fraction have a circulating factor that depresses invitro myocardial cell performance. J. E. Parrilo, C. Burch,J. H. Shelhamer, M. M. Parker, C. Natanson, and W.Schuette .A distant gene deletion affects fl-g~lobin gene function in anatypical 765-thalassemia. P. Curtin, M. Pirastu, Y. WKan, J. A. Gobert-Jones, A. D. Stephens, and H. LehmannHuman fat cell lipolysis is primarily regulated byinhibitory modulators acting through distinct mechanisms.H. Kather, W Bieger, G. Michel, K. Aktories, and K H.Jakobs.Ele~ctrophysiologic mechanisms of functional bundlebranch block at onset of induced orthodromic tachycardiain the Wolff-Parkinson-White syndrome. Role ofstimulation method. M. H. Lehmann, S. Denker, R.Mahmud, P. Tchou, J. Dongas, and M. Akhtar.In vivo stimulation of sugar uptake in rat thymocytes. Anextranuclear action of 3,5,3'-triiodothyronine. J. Segal andS. H. Ingbar.....................Use of an X-linked human neutrophil marker to estimatetiming of Iyonization and size of the dividing stem cellpool. E. S. Buescher, D. W Alling, and J. I. Gallin .Presence of epidermal-derived thymocyte activating factor/interleukin 1 in normal human stratum corneum. L. C.Gahring, A. Buckley, and R. A. Daynes.Interaction of cardiopulmonary and carotid baroreflexcontrol of vascular resistance in humans. R. G. Victor andA. L. Mark .....................Evidence that blood ionized calcium can regulate serum1,25(OH)2D3 independently of parathyroid hormone andphosphorus in the rat. D. A. Bushinsky, G. S. Riera, M. J.Favys, and F. L.Coe.Sickle erythrocyte adherence to vascular endothelium.Morphologic correlates and the requirement for divalentcations and collagen-binding plasma proteins. N.Mohandas and E.Evans.Interleukin 3 promotes the in vitro proliferation of murinepluripotent hematopoietic stem cells. J. L. Spivak,R. R. L. Smith, and J. N.Ihle.Intrathecal triiodothyronine administration causes greaterheart rate stimulation in hypothyroid rats thanintravenously delivered hormone. Evidence for a centralnervous system site of thyroid hormone action. M.Goldman, M. B. Dratman, F. L. Crutchfield, A. S.Jennings, J. A. Maruniak, and R. Gibbons .

Long-term effects of dietary marine w-3 fatty acids uponplasma and cellular lipids, platelet function, andeicosanoid formation in humans. C. von Schacky, S.

1514 Fischer, and P. C. Weber.Prevention of bedrest-induced physical deconditioning bydaily dobutamine infusions. Implications for drug-inducedphysical conditioning. M. J. Sullivan, P. F. Binkley, D. V.Unverferth, J.-H. Ren, H. Boudoulas, T. M. Bashore, A. J.

1522 Merola, and C. V. Leier .Activity in fetal bovine serum that stimulates erythroidcolony formation in fetal mouse livers is insulinlikegrowth factor I. A. Kurtz, W. Hdrtl, W. Jelkmann, J. Zapf;

1530 and C. Bauer.Anti-idiotypic antibodies against a human multiple organ-

1536 reactive autoantibody. Detection of idiotopes in normalindividuals and patients with autoimmune diseases. K.Essani, J. Satoh, B. S. Prabhakar, P. R. McClintock, andA. L. Notkins.

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Selective expression of phosphoribosylpyrophosphatesynthetase superactivity in human lymphoblast lines. M. J.Losman, D. Rimon, M. Kim, and M. A. Becker.Metabolism of pantethine in cystinosis. C. T. Wittwer,W. A. Gahl, J. DeB. Butter, M. Zatz, and J. G. ThoeneLinkage of a membrane skeleton to integral membraneglycoproteins in human platelets. Identification of one ofthe glycoproteins as glycoprotein Ib. J. E. B. Fox

Rapid Publications

Plasma levels of immunoreactive atrial natriuretic factorin healthy subjects and in patients with edema. Y.Shenker, R. S. Sider, E. A. Ostafin, and R. J. GrekinIn vitro function of cyst epithelium from human

1566 polycystic kidney. R. D. Perrone.

Diabetes in the Bio-Breeding/Worcester rat. Induction andacceleration by spleen cell-conditioned media. E. S.

1575 Handler, J. P. Mordes, J. Seals, S. Koevary, A. A. Like, K

Nakano, and A. A. Rossini .

1581Erythrocyte survival in chronic renal failure. Role ofsecondary hyperparathyroidism. M. Akmal, N. Telfer,

A. N. Ansari, and S. G.Massry.Prospective study of cytotoxic T lymphocyte responses to

1585 influenza and antibodies to human T lymphotropic virus-

III in homosexual men. Selective loss of an influenza-specific, human leukocyte antigen-restricted cytotoxic T

1592 lymphocyte response in human T lymphotropic virus-IIlpositive individuals with symptoms of acquiredimmunodeficiency syndrome and in a patient withacquired immunodeficiency syndrome. G. M. Shearer,

1599 Salahuddin, Markham, J. Joseph, S.

Payne, P. Kriebel, D. C. Bernstein, W. E. Biddison, M. G.Sarngadharan, and R. C. GalloAtrialnatriuretic factor in human blood. T. Yamaji, M.Ishibashi, and F. Takaku.October AuthorIndex.

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Contents

The Journal of Clinical InvestigationNovember 1985, Volume 76, Number 5

PerspectivesMyocardial reperfusion: a double-edged sword? E.Braunwald and R. A. Kloner .

Regular ArticlesStereoselective renal clearance of pindolol in humans.P.-H. Hsyu andK M. Giacomini .Effects of bile and bile salts on growth and membrane lipiduptake by Giardia lamblia. Possible implications forpathogenesis of intestinal disease. M. J. G. Farthing, G. T.Keusch, and M. C. Carey.Profiles of steady state levels of messenger RNAs codingfor type I procollagen, elastin, and fibronectin in hamsterlungs undergoing bleomycin-induced interstitialpulmonary fibrosis. R. Raghow, S. Lurie, J. M. Seyer, andA. H. Kang .....................Tracer norepinephrine kinetics in coronary circulation ofpatients with heart failure secondary to chronic pressureand volume overload. C. P. Rose, J. H. Burgess, and D.Cousineau.Suppression of murine neuroblastoma growth in vivo bymevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. W. A. Maltese, R.Defendini, R. A. Green, K. M. Sheridan, and D. K DonleyTherapeutic concentrations of glucocorticoids suppress theantimicrobial activity of human macrophages withoutimpairing their responsiveness to gamma interferon. A.Schaffner.Mechanism of action of blocking immunoglobulin G forNeisseria gonorrhoeae. K. A. Joiner, R. Scales, K. A.Warren, M. M. Frank, and P. A. Rice .Regulation of rat biliary cholesterol secretion by agentsthat alter intrahepatic cholesterol metabolism. Evidencefor a distinct biliary precursor pool. B. G. Stone, S. K.Erickson, W. Y. Craig, and A. D. Cooper.Rates of noninsulin-mediated glucose uptake are elevatedin type II diabetic subjects. A. D. Baron, 0. G. Kolterman,J. Bell, L. J. Mandarino, and J. M. Olefsky.Calcium transport abnormality in uremic rat brainsynaptosomes. C. L. Fraser, P. Sarnacki, and A. I. ArieffDisparate mechanisms for hypoxic cell injury in differentnephron segments. Studies in the isolated perfused ratkidney. M. Brezis, P. Shanley, P. Silva, K. Spokes, S.Lear, F. H. Epstein, and S.Rosen.Effect of atrial peptides on aldosterone production. K.Atarashi, P. J. Mulrow, and R. Franco-Saenz.Bradykinin stimulation of oxidative metabolism in renalcortical tubules from rabbit. Possible role of arachidonicacid. P. C. Brazy, D. R. Trellis, and P. E. Klotman .Metabolic fate of extracted glucose in normal humanmyocardium. J. A. Wisneski, E. W. Gertz, R. A. Neese,L. D. Gruenke, D. L. Morris, and J. C. Craig.

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Chloride secretory mechanism induced by prostaglandinE, in a colonic epithelial cell line. A. Weymer, P. Huott,W. Liu, J. A. McRoberts, andK DharmsathaphornSynergistic action of cyclic adenosine monophosphate- andcalcium-mediated chloride secretion in a colonic epithelialcell line. C. A. Cartwright, J. A. McRoberts, K G. Mandel,andK Dharmsathaphorn.Mechanoelectrical feedback: independent role of preloadand contractility in modulation of canine ventricularexcitability. B. B. Lerman, D. Burkhoff D. T. Yue, andKSagawa.Inhibition of parathyroid hormone secretion andparathyroid hormone-independent diminution of tubularcalcium reabsorption by WR-272 1, a unique hypocalcemicagent. S. Hirschel-Scholz, J. Caverzasio, and J.-P. BonjourCharacterization of human platelet vasopressin receptors.M. Thibonnier and J. M. Roberts .

Spontaneous immunoglobulin A secretion and lack ofmitogen-responsive B cells in systemic lupus

1740 erythematosus. 0. Saiki, Y. Saeki, and S. Kishimoto

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Calcium uptake by intestinal brush border membranevesicles. Comparison with in vivo calcium transport. H. P.Schedl and H. D. Wilson.Vitamin K-dependent carboxylation and vitamin Kmetabolism in liver. Effects of warfarin. R. Wallin andL. F. Martin .....................Studies on multiple thyroid cell membrane-directedantibodies in Graves' disease. M. Zakarija, A. Garcia, andJ. M. McKenzie ...................Altered proopiomelanocortin gene expression inadrenocorticotropin-producing nonpituitary tumors.Comparative studies with corticotropic adenomas andnormal pituitaries. Y. de Keyzer, X. Bertagna, F. Lenne, F.Girard, J.-P. Luton, and A. Kahn . . . . . . . . . . . .

A kallikrein-like seine protease in prostatic fluid cleavesthe predominant seminal vesicle protein. H. Lilja .

Hepatic microcirculation in the perfused cirrhotic rat liver.F. Varin and P.-M.Huet.

1789 Role of renal sympathetic nerves in mediatinghypoperfusion of renal cortical microcirculation inexperimental congestive heart failure and acuteextracellular-fluid volume depletion. V. Kon, A. Yared,and I.Ichikawa.

1796 Inner-ring deiodination of 3,5,3'-triiodothyronine in the insitu perfused guinea pig placenta. M. I. Castro, L. E.

1807 Braverman, S. Alex, C.-F. Wu, and C. H. Emerson .

Membrane markers, target cell specificity, and sensitivityto biological response modifiers distinguish human natural

1812 cytotoxic from human natural killer cells. M. Rola-Pleszczynski, H. Lieu, A. K Sullivan, and M. Girard

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1904

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Activation of the human neutrophil nicotinamide adeninedinucleotide phosphate (NADPH)-oxidase by proteinkinase C. J. A. Cox, A. Y. Jeng, N. A. Sharkey, P. M.Blumberg, and A. I. Tauber . . . . . . . . . . . . . .

Distribution of renin activity and angiotensinogen in ratbrain. Effects of dietary sodium chloride intake on brainrenin. C. P. Genain, G. R. Van Loon, and T. A. Kotchen3-Hydroxy-3-methylglutaryl coenzyme A reductase inanencephalic and normal human fetal liver. B. R. Carr,W E. Rainey, and J. I. Mason .Independent modulation of von Willebrand factor andfibrinogen binding to the platelet membrane glycoproteinIIb/IIIa complex as demonstrated by monoclonalantibody. V. Trapani Lombardo, E. Hodson, J. R.Roberts, T. J. Kunicki, T. S. Zimmerman, and Z. M. Ruggeri

Production of and in vitro response to interleukin 2 in theacquired immunodeficiency syndrome. H. W. Murray, KWelte, J. L. Jacobs, B. Y. Rubin, R. Mertelsmann, andR. B. Roberts ....................Polymorphism of the complement receptor for C3bi. G. R.Russ, A. P. Haddad, B. D. Tait, and A. J. F. d'ApiceEffect of hydrogen peroxide exposure on normal humanerythrocyte deformability, morphology, surfacecharacteristics, and spectrin-hemoglobin cross-linking.L. M. Snyder, N. L. Fortier, J. Trainor, J. Jacobs, L. Leb,B. Lubin, D. Chiu, S. Shohet, and N. Mohandas.A monoclonal antibody against basal cells of humanepidermis. Potential use in the diagnosis of cervicalneoplasia. V. B. Morhenn, A. B. Schreiber, 0. Soriero, W.McMillan, and A. C. Allison . . . . . . . . . . . ..

Isolation and characterization of glycosaminoglycans inhuman. plasma. I. Staprans and J. M. Felts .......

1932

Pathogenesis of heterogeneity in human multinodulargoiter. A study on growth and function of thyroid tissuetransplanted onto nude mice. H. J. Peter, H. Gerber, H.Studer, and S.Smeds.Interleukin 1 acts on cultured human vascularendothelium to increase the adhesion of

1939 polymorphonuclear leukocytes, monocytes, and relatedleukocyte cell lines. M. P. Bevilacqua, J. S. Pober, M. E.Wheeler, R. S. Cotran, and M. A. Gimbrone, Jr.

1946 Defective binding and function of 1,25-dihydroxyvitaminD3 receptors in peripheral mononuclear cells of patientswith end-organ resistance to 1,25-dihydroxyvitamin D. R.Koren, A. Ravid, U. A. Liberman, Z. Hochberg, Y.Weisman, and A. Novogrodsky .

1950

1959

Rapid PublicationsHuman transforming growth factor-alpha stimulates boneresorption in vitro. P. H. Stern, N. S. Krieger, R. A.Nissenson, R. D. Williams, M. E. Winkler, R. Derynck,and G. J. Strewler.Immunoglobulin G is a platelet alpha granule-secreted

1965 protein. J. N. George, S. Saucerman, S. P. Levine, L. KKnieriem, and D. F. Bainton .

1971

1978

Immunoreactive corticotropin-releasing factor in humanplasma. T. Suda, N. Tomori, F. Yajima, T. Sumitomo, Y.Nakagami, T. Ushiyama, H. Demura, andK ShizumeThe transmembrane pH gradient drives uphill folatetransport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles.C. M. Schron, C. Washington, Jr., and B. L. Blitzer .

Correction.Correction...h.r.c.e.i.a.i.n.o. . . . ..n.g..a..in

1984 November Author Index.

1992

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2012

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2030203520372039

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Contents

The Journal of Clinical InvestigationDecember 1985, Volume 76, Number 6

PerspectivesBiologically active atrial peptides. B. J. Ballermann andB. M. Brenner ....................

Regular ArticlesPhysiologic regulation of atrial natriuretic peptidereceptors in rat renal glomeruli. B. J. Ballermann, R. L.Hoover, M. J. Karnovsky, and B. M. Brenner.Cobalamin malabsorption in three siblings due to anabnormal intrinsic factor that is markedly susceptible toacid and proteolysis. Y. Yang, R. Ducos, A. J. Rosenberg,P. G. Catrou, J. S. Levine, E. R. Podell, and R. H. AllenAbsence ofgamma interferon and interleukin 2production during active visceral leishmaniasis. E. M.Carvalho, R. Badaro, S. G. Reed, T. C. Jones, andW. D. Johnson, Jr. ..................

Recognition of human insulin in vitro by T cells fromsubjects treated with animal insulins. L. J. Nell, V. J.Virta, and J. W Thomas.Human histocompatibility leukocyte antigen (HLA)haplotype frequencies estimated from the data on HLAclass I, II, and III antigens in 111 Japanese narcoleptics. KMatsuki, T. Juji, K Tokunaga, T. Naohara, M. Satake,and Y. Honda ....................Self-perpetuating mechanisms of immunoglobulin Gaggregation in rheumatoid inflammation. J. Lunec, D. R.Blake, S. J. McCleary, S. Brailsford, and P. A. BaconGlucose transport and metabolism in adipocytes fromnewly diagnosed untreated insulin-dependent diabetics.Severely impaired basal and postinsulin binding activities.E. Hjallund, 0. Pedersen, B. Richelsen, H. Beck-Nielsen,and N. S.Sorensen.Ischemia induces partial loss of surface membrane polarityand accumulation of putative calcium ionophores. B. A.Molitoris, P. D. Wilson, R. W Schrier, and F. R. SimonO6Alkylguanine-DNA alkyltransferase activity in humanmyeloid cells. S. L. Gerson, K Miller, and N. A. BergerIsolation, characterization, and distribution of an unusualpancreatic human secretory protein. J. Gross, R. I.Carlson, A. W. Brauer, M. N. Margolies, A. L. Warshaw,and J. R.Wands.Formation of soluble immune complexes by complementin sera of patients with various hypocomplementemicstates. Difference between inhibition of immuneprecipitation and solubilization. J. A. Schifferli, G. Steiger,G. Hauptmann, P. J. Spaeth, and A. G. Sjoholm.Monoclonal antibodies to T-2 toxin. In vitroneutralization of protein synthesis inhibition andprotection of rats against lethal toxemia. G. Feuerstein,J. A. Powell, A. T. Knower, andK W. Hunter, Jr.

Analysis of helper activity on pokeweed mitogen- andinterleukin 2-driven immunoglobulin synthesis by

2041 neoplastic T4' cells. F. Miedema, J. W. van Oostveen,F. G. Terpstra, A. W. L. van den Wall Bake, R. Willemze,E. A. J. Rauws, R. Bieger, M. B. van't Veer, D. Catovsky,and C J. m.Melief .

Biosynthesis of the transferrin receptor in rabbit2049 reticulocytes. T. M. Cox, M. W. O'Donnell, P. Aisen, and

I. M. London.A relationship between ultrasonic integrated backscatterand myocardial contractile function. S. A. Wickline, L. J.

2057 Thomas III, J. G. Miller, B. E. Sobel, and J. E. PerezAn intragenic deletion of the Factor IX gene in a familywith hemophilia B. S.-H. Chen, S. Yoshitake, P. F.Chance, G. L. Bray, A. R. Thompson, C. R. Scou, andK

2066 Kurachi .......................Dietary intake of sodium chloride in the rat influences[3H]nitrendipine binding to adrenal glomerulosa cell

2070 membranes but does not alter binding to vascular smoothmuscle membranes. R. J. Schiebinger andK Kontrimus

2078

Biochemical marker in familial amyloidoticpolyneuropathy, Portuguese type. Family studies on thetransthyretin (prealbumin)-methionine-30 variant.M. J. M. Saraiva, P. P. Costa, and D. S. Goodman .

Thrombomodulin is present in human plasma and urine.H. Ishii and P. W Majerus.

2084 DNA binding to human leukocytes. Evidence for areceptor-mediated association, internalization, anddegradation of DNA. R. M. Bennett, G. T. Gabor, andM. M. Merritt.

Lysosomal enzyme phosphorylation in human fibroblasts.2091 Kinetic parameters offer a biochemical rationale for two

distinct defects in the uridine diphospho-N-acetylglu-cosamine:lysosomal enzyme precursor N-

2097 acetylglucosamine-l-phosphotransferase. L. Lang, T.Takahashi, J. Tang, and S. Kornfeld.

2106 Demonstration and partial characterization of theinterferon-gamma receptor on human mononuclearphagocytes. A. Celada, R. Allen, I. Esparza, P. W Gray,and R. D. Schreiber .

2115 In vitro prostacyclin production by ovine uterine andsystemic arteries. Effects of angiotensin II. R. R. Magness,K Osei-Boaten, M. D. Mitchell, and C. R. Rosenfeld

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Renal cortex taurine content regulates renal adaptiveresponse to altered dietary intake of sulfur amino acids.R. W Chesney, N. Gusowski, and S. Dabbagh . . . . . . 2213Effect of metabolic clearance rate and hepatic extraction ofinsulin on hepatic and peripheral contributions tohypoglycemia. Z. Chap, T. Ishida, J. Chou, C. J. Hartley,R. M. Lewis, M. Entman, and J. B. Field . . . . . . . . 2222

Xlll

Thrombin stimulates the adherence of neutrophils tohuman endothelial cells in vitro. G. A. Zimmerman, T. M.McIntyre, and S. M. Prescott .Nasal challenge with ragweed pollen in hay fever patients.Effect of immunotherapy. P. S. Creticos, N. F. Adkinson,Jr., A. Kagey-Sobotka, D. Proud, H. L. Meier,R. M. Naclerio, L. M. Lichtenstein, and P. S. NormanEstimation of bone turnover evaluated by 4'7Ca-kinetics.Efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, andurinary hydroxyproline excretion. P. Charles, J. W. Poser,L. Mosekilde, and F. T. Jensen.Loss of high affinity cardiac beta adrenergic receptors indogs with heart failure. D. E. Vatner, S. F. Vatner, A. M.Fujii, and C. J.Homcy.Relative contribution of aortic and carotid baroreflexes toheart rate control in man during steady state and dynamicincreases in arterial pressure. D. W Ferguson, F. M.Abboud, and A. L. Mark . . . . . . . . . . . . . . .

Erythrocyte echinocytosis in liver disease. Role ofabnormal plasma high density lipoproteins. J. S. Owen,D. J. C. Brown, D. S. Harry, N. McIntyre, G. H. Beaven,H. Isenberg, and W. B. Gratzer ............Effects of thromboxane synthase inhibition on vascularresponsiveness in the in vivo rat mesentery. E. K JacksonPotential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source oftriiodothyronine in rats. J. E. Silva and P. R. LarsenInsulin-mediated reduction of whole body proteinbreakdown. Dose-response effects on leucine metabolismin postabsorptive men. N. K Fukagawa, K L. Minaker,J. W. Rowe, M. N. Goodman, D. E. Matthews, D. M. Bier,and V, R. Young ...................1,25-dihydroxyvitamin D increases calmodulin binding tospecific proteins in the chick duodenal brush bordermembrane. D. D. Bikle and S. Munson.Human platelet Fc receptor for immunoglobulin G.Identification as a 40,000-molecular-weight membraneprotein shared by monocytes. S. I. Rosenfeld, R. J.Looney, J. P. Leddy, D. C. Phipps, G. N. Abraham, andC. L. Anderson .. . . . . . . . . . . . . . . . .. .

Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. G. R.Grotendorst, G. R. Martin, D. Pencev, J. Sodek, and A. KHarvey.A unique elastase in human blood platelets. H. L. James,Y. T. Wachtfogel, P. L. James, M. Zimmerman, R. W.Colman, and A. B.Cohen.Network interactions in Schistosoma japonicum infection.Identification and characterization of a serologicallydistinct immunoregulatory auto-antiidiotypic antibodypopulation. G. R. Olds and T. F. Kresina.Structural requirements for parathyroid hormone action inmature bone. Effects on release of cyclic adenosinemonophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters. M. S.Calvo, M. J. Fryer, K J. Laakso, R. A. Nissenson, P. A.Price, T. M. Murray, and H. HeathIII.Insulin receptor biosynthesis in cultured lymphocytes frominsulin-resistant patients. J. A. Hedo, V Y. Moncada, andS. I. Taylor .....................

Oral administration of human serum immunoglobulin inimmunodeficient patients with viral gastroenteritis. A

2235 pharmacokinetic and functional analysis. G. A. Losonsky,J. P. Johnson, J. A. Winkelstein, and R. H. Yolken .Interaction of human monocytes, macrophages, andpolymorphonuclear leukocytes with zymosan in vitro.

2247 Role of type 3 complement receptors and macrophage-derived complement. R. A. B. Ezekowitz, R. B. Sim, G. G.MacPherson, and S.Gordon.

2254

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Intracellular respiratory dysfunction and cell injury inshort-term anoxia of rabbit renal proximal tubules. T.Takano, S. P. Soltoff: S. Murdaugh, and L. J. MandelDeficiency of the adhesive protein complex lymphocytefunction antigen 1, complement receptor type 3,glycoprotein p150,95 in a girl with recurrent bacterialinfections. Effects on phagocytic cells and lymphocytefunctions. A. Fischer, R. Seger, A. Durandy, B. Grospierre,J. L. Virelizier, F. Le Deist, C. Griscelli, E. Fischer, M.Kazatchkine, M.-C. Bohler, B. Descamps-Latscha, P. H.Trung, T. A. Springer, D. Olive, and C. Mawas.In vivo and in vitro studies on formation of bile acids inpatients with Zellweger syndrome. Evidence thatperoxisomes are of importance in the normal biosynthesisof both cholic and chenodeoxycholic acid. B. F. Kase, J. I.Pedersen, B. Strandvik, and I. Bjorkhem.Irreversible bone loss in osteomalacia. Comparison ofradial photon absorptiometry with iliac bonehistomorphometry during treatment. A. M. Parfitt, D. S.

2296 Rao, J. Stanciu, A. R. Villanueva, M. Kleerekoper, and B.Frame .

Rapid PublicationsAtriopeptin III. A potent natriuretic, diuretic, and

2306 hypotensive agent in rats with chronic renal failure. B. R.Cole, M. A. Kuhnline, and P. Needleman.Z-Nucleotide accumulation in erythrocytes from Lesch-

2312 Nyhan patients. Y. Sidi and B. S. Mitchell.Serum vitamin D-binding protein is a third member of thealbumin and alpha fetoprotein gene family. N. E. Cookeand E. V.David.Beta-2 microglobulin is an amyloidogenic protein in man.

2317 P. D. Gorevic, T. T. Casey, W. J. Stone, C. R.DiRaimondo, F. C. Prelli, and B. Frangione .Stimulation of porcine jejunal ion secretion in vivo byprotein kinase-C activators. C. S. Weikel, J. J. Sando, and

2323 R. L. Guerrant ..... . . . . . . . ........

2330

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Sn-protoporphyrin suppresses chemically inducedexperimental hepatic porphyria. Potential clinicalimplications. R. A. Galbraith, G. S. Drummond, and A.Kappas.Tissue factor induction in human monocytes. Two distinctmechanisms displayed by different alloantigen-responsiveT cell clones. S. A. Gregory and T. S. Edgington.Metabolism and effects on platelet function of the purifiedeicosapentaenoic and docosahexaenoic acids in humans.C. von Schacky and P. C. Weber.Correction.December AuthorIndex.

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2403

2413

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2436

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244624512454

Author Index to Volume 76 . . . . . . . . . . . . . . 2455

2355

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