Nw2013 retinopathies inpregnancyfinal
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Transcript of Nw2013 retinopathies inpregnancyfinal
Nawat WatanachaiChiangmai University Hospital
RCOPT mid 2013
Many emotional and physical changes
including eyes
Normal eye changes in pregnancy Pregnancy induced chorioretinopathy Retinal diseases that are affected by pregnancy
Cornea◦ increase thickness 1◦ Increase curvature 2◦Decrease sensitivity 3
Lens◦ Increase thickness 1◦ Increase curvature 1
IOP◦Decrease in 3rd trimester 4
1 Riss B, Riss P. Corneal sensitivity in pregnancy. Ophthalmologica 1981; 183:57—62.2 Weinreb RN, Lu A, Beeson C. Maternal corneal thickness during pregnancy. Am J Ophthalmol 1988; 105:258—260.3 Park SB, Lindahl KJ, Temnycky GO, Aquavella JV. The effect of pregnancy on the corneal curvature. CLAO J 1992;
18:256—259.4 Akar Y, Yucel I, Akar ME, et al. Effect of pregnancy on intraobserver and intertechnique agreement in intraocular
pressure measurements. Ophthalmologica 2005; 219:36—42.
Retina◦Retinal thickness
slightly increases during 2nd-3rd trimesters 1
◦Retinal venous diameter decreased during the 3rd trimester 2
1. Dinn, Robert B. BS*; Harris, Alon MSc, PhD†; Marcus, Peter S. MD‡. Ocular Changes in Pregnancy. Obstetrical & Gynecological Survey: February 2003 - Volume 58 - Issue 2 - pp 137-1442. The effect of pregnancy on retinal hemodynamics in diabetic versus nondiabetic mothers ☆
Lisa S Schocket, MDa, Juan E Grunwald, MDa, , , Amy F Tsang, MAa, Joan DuPonta American Journal of OphthalmologyVolume 128, Issue 4, October 1999, Pages 477–484
● Early preg -> hyperdynamic circulation● controlled by an autoregulatory mechanism in the
retinal vasculature– Success not develop retinopathy– Failed
increased blood flow velocity
petential damage to capillary endothelium
Chen HC et al. Retinal blood flow changes during pregnancy in women with diabetes. Invest Ophthalmol Vis Sci 1994; 35:3199–3208.
Central serous chorioretinopathy (CSCR) Valsava retinopathy Purtscher’s retinopathy Preeclampsia/ eclampsia associated retinopathy
◦(HT retinopathy)
RAO, RVO Bullous ERD
● 10:1 male predominance outside the context of pregnancy
● closure when women become pregnant
Chumbley LC, Frank RN. Central serous retinopathy and pregnancy. Am J Ophthalmol 1974; 77:158—160.
● CSCR ● unilateral ● with or without fibrin formation
● Most cases ● occurred during the 3rd trimester ● recurring in subsequent pregnancies
Sunness JS, Haller JA, Fine SL. Central serous chorioretinopathy and pregnancy. Arch Ophthalmol 1993; 111:360—364.
Gass JDM. Central serous chorioretinopathy and white subretinal exudation during pregnancy. Arch Ophthalmol 1991; 109:677—681.
● Investigations● OCT >>>>>> FA/ICG
● CSCR● spontaneously resolved
during the early postpartum ● not associated with any adverse
fetal outcomes C/S Rx● conservatives
● unilateral or bilateral ● self limiting● increased intra-thoracic or
intraabdominal pressure● sharp rise in the intra-
ocular venous pressure● rupture of superficial
retinal capillaries● Constipation/ delivery
● No specific treatment is needed● Laser posterior hyaloidotomy
● the diagnosis should be made only after excluding other causes of retinal haemorrhages
● (reported) developing after child birth● Preeclampsia/ eclampsia● compliment activated leuko-embolus formation?
● No treatment is needed
● How common● 25% of the patients with preeclampsia ● 50% with eclampsia ● Mostly asymptomatic● Few suffers visual disturbance
● blurred vision, diplopia, photopsia, scotomata, amaurosis and chromatopsia and cortical blindness
DieckmannWJ (1952) The toxemias of pregnancy, 2nd edn. Mosby, St Louis
● common ocular findings● Focal/ general constriction or
spasm of the retinal arterioles● CWS● intra retinal haemorrhages,
retinal oedema● optic nerve oedema
● in a patient with mild preeclampsia ● Look for cowexisting DM/
chronic HT Jaffe G, Schatz H Ocular manifestations of preeclampsia. Am J Ophthalmol 1987;103:309–315
● Choroidal involvement● yellow- white focal lesions at the level of
the RPE● serous retinal detachment
● often bullous● usually bilateral
● Elschnig’s spots● small, isolated areas of
hyperpigmentation● surrounding yellow or red halos
A.M. Joussen, T.W.Gardner, B. Kirchhof , S.J. Ryan . Retinal Vascular Disease:691-699
● prognosis ● Good● Generally do not need specific
treatment● But NEED Systemic
treatment ● antihypertensive therapy● magnesium sulfate● early delivery of the fetus when
indicated
A.M. Joussen, T.W.Gardner, B. Kirchhof , S.J. Ryan . Retinal Vascular Disease:691-699
● pre-existing DM● preexisting
posterior uveitis
● Changes in hemodynamics ● increased level of various growth factors and
hormones
● DR may start/ progress during pregnancy● Who will be attacked? Risk factors
Chew EY, Mills JL, Metzger BE, et al. Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. DiabetesCare 1995; 18:631—637.
DM duration DR Progression
<15 yrs 18%
> 15 yrs 39%
● The Diabetes in Early Pregnancy Study (DIEP)– Prospective cohort– 140 pregnant diabetic women
– Retinopathy was most likely to progress in ● Poorest control at baseline ● largest improvement during early pregnancy
Chew EY, Mills JL, Metzger BE, et al. Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. DiabetesCare 1995; 18:631—637.
Chew EY, Mills JL, Metzger BE, et al. Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. DiabetesCare 1995; 18:631—637.
Baseline DR progression Progression to PDR
No DR 10.3% -
Only microaneurysms
21.1% -
Mild NPDR 18.8% 6.3%
Moderate NPDR 54.8% 29%
● additionally hazardous during pregnancy● In at least one major study,
● all patients with severe PDR● also had proteinuria indicating a generalized vasculopathy
● DR in patients with eclampsia/preeclampsia is more likely to progress
Phelps RL et al Changes in diabetic retinopathy during pregnancy. Correlations with regulation of hyperglycemia. Arch Ophthalmol 1984; 104:1806–1810
● rapid normalization of sugar level● hypoglycemia ● retinal hypoxia and ● new CWS and intra retinal microvascular
abnormalities
Chew EY, Mills JL, Metzger BE, et al. Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. DiabetesCare 1995; 18:631—637.
● Risk factors for the DR progression– Duration of DM 1– Poor metabolic control– Baseline severity of DR– HT, PIH and preeclampsia 2,3– Rapid normalization of glucose levels during pregnancy 1
1. 1. Chew EY, Mills JL, Metzger BE, et al. Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. DiabetesCare 1995; 18:631—637.
2. 2. Rosenn B, Miodovnik M, Kranias G, et al. Progression of diabetic retinopathy in pregnancy: association with hypertension in pregnancy. Am J Obstet Gynecol 1992; 166:1214—1218.
● 8. Loukovaara S, Harju M, Kaaja R, Immonen I. Retinal capillary blood flow in diabetic and nondiabetic women during pregnancy and postpartum period. Invest Ophthalmol Vis Sci 2003; 44:1486—1491.
● early education and good counselling of diabetic women in childbearing age
● good glucose control● Treat diabetic retinopathy
prior to conception
I know it
● DR that progress during pregnancy commonly regress after delivery
● But somes with rapid progression or high-risk PDR will progress● Can cause VH/ TRD/ NVG/ blindness● Should be treated
Chan WC, Lim LT, Quinn MJ, et al. Management and outcome of sightthreatening diabetic retinopathy in pregnancy. Eye 2004; 18:826—832.
● non-infectious uveitis● May flare-up in disease activity within the 1st trimester● And then slow down later● Rebound within 6 months of delivery.
Peter K Rabiah,Albert T Vitale. Noninfectious uveitis and pregnancy. American Journal of Ophthalmology 2003; 136:91-98
● Most common ● VKH and Behcet disease
● Most flare-ups were effectively treated with observation/corticosteroids
Peter K Rabiah,Albert T Vitale. Noninfectious uveitis and pregnancy. American Journal of Ophthalmology 2003; 136:91-98
Central serous chorioretinopathy (CSCR) Valsava retinopathy Purtscher’s retinopathy Preeclampsia/ eclampsia associated retinopathy
◦(HT retinopathy)
● pre-existing DM● preexisting posterior uveitis
We need healthy moms to take care of these
guys!