NuGenesis · Guidance on Waters' services and product features, including technical tips and tricks...
Transcript of NuGenesis · Guidance on Waters' services and product features, including technical tips and tricks...
©2019 Waters Corporation 1COMPANY CONFIDENTIAL
NuGenesisSDMS/LMS
©2019 Waters Corporation 2COMPANY CONFIDENTIAL
©2019 Waters Corporation 3COMPANY CONFIDENTIAL
ISO17025:2017
©2019 Waters Corporation 4COMPANY CONFIDENTIAL
General requirements for the competence of testing and calibration laboratories
Stronger focus on Information technologies
– Includes use of computer systems, electronic records, and production of electronic results and reports
Risk-based thinking
Matches latest revision of ISO 9001
Control of data
ISO 17025: 2017 Update
©2019 Waters Corporation 5COMPANY CONFIDENTIAL
§7.11.3 The laboratory information management system(s) shall:
a) be protected from unauthorized access;
b) be safeguarded against tampering and loss;
c) be operated in an environment that complies with provider or laboratory specifications or, in the case of
non-computerized systems, provides conditions which safeguard the accuracy of manual recording and
transcription;
d) be maintained in a manner that ensures the integrity of the data and information;
e) include recording system failures and the appropriate immediate and corrective actions.
NOTE 1 In this document “laboratory information management system(s)” includes the management of data and information contained in both computerized and non-computerized
systems. Some of the requirements can be more applicable to computerized systems than to non-computerized systems.
NOTE 2 Commercial off-the-shelf software in general use within its designed application range can be considered to be sufficiently validated.
2017 Requirements for laboratory information
management system(s)
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ALCOA+
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ALCOA+
Key Factor in Data Integrity
A
Attributable Zurechenbar
L
Legible Lesbar
C
Contemporaneous Gleichzeitig
O
Original Original
A
Accurate Genau
+
Complete Komplett
Consistent Konsistent
Enduring Dauerhaft
Available Verfügbar
Stan W. Woollen, Sr. Compliance Advisor
©2019 Waters Corporation 8COMPANY CONFIDENTIAL
ALCOA+
Key Factor in Data Integrity
A
Attributable Wer hat die Daten aufgenommen / die Aktion durchgeführt?
L
Legible Sind die Daten lesbar und verständlich?
C
Contemporaneous Wurden die Daten zur Zeit ihres Entstehens dokumentiert?
O
Original Sind die Daten das Orginal oder eine verifizierte Kopie?
A
Accurate Sind die Daten wissenschaftlich valide und fehlerfrei?
+
Complete Sind das alle Daten oder gibt es Wiederholungen Reanalysen
Consistent Alle Elemente der Analyse sind in Reihenfolge mit Datum/Uhrzeit versehen
Enduring In einer dauerhaften, wartbaren Form während des gesamten Lebenszyklus aufgezeichnet
Available Zur Überprüfung, Prüfung oder Inspektion über die gesamte Lebensdauer der Aufzeichnung
Stan W. Woollen, Sr. Compliance Advisor
©2019 Waters Corporation 9COMPANY CONFIDENTIAL
ALCOA + ISO 17025 Requirement
Attributable§7.5.1 … technical records shall include the date and identity of
personnel responsible for each activity and for checking data and results
Legible§7.5.2 … ensure that amendments to technical records can be tracked to
previous versions or to original observations
Contemporaneous§7.5.1 Original observations, data and calculations should be recorded at the
time they are made…
Original§7.5.2 … original and amended data and files shall be retained
Accurate§7.11.3 c) … provides conditions which safeguard the accuracy of manual
recording and transcription
Hidden ALCOA+ Requirements in ISO 17025
©2019 Waters Corporation 10COMPANY CONFIDENTIAL
ALCOA + ISO 17025 Requirement
Complete§7.11.3 e) include recording system failures and the appropriate immediate and
corrective actions
Consistent
§7.11.6 Calculations and data transfers shall be checked in an appropriate and
systematic manner; §7.11.2 the … system(s) used for collection, processing
recording, reporting, storage or retrieval of data … shall be validated for
functionality… including the proper functioning of interfaces
Enduring§7.11.3 b) … be safeguarded against tampering and loss
Available
§8.4.2 …shall implement the controls needed for the identification, storage,
protection, back-up, archive, retrieval, retention time, and disposal of its
records. … records shall be readily available.
Hidden ALCOA+ Requirements in ISO 17025
©2019 Waters Corporation 11COMPANY CONFIDENTIAL
M2: Data Integrity Maturity Level
A stand-alone guide, that is aligned and can be used in parallel with GAMP® 5 and the
Good Practise Guides
– Based upon life sciences regulations and guidance (GCP, GMP, GLP, and medical Devices) including
recent Data Integrity Guidances, 21 CFR Part 11, Chapter 4 Annex 11, ICH Q9, & ICH Q10
– Main body consists of 5 main chapters
o Introduction
o Regulatory Focus
o Data Governance Framework
o Data Life Cycle
o Quality Risk Management
– M3 Human Factors
– M4 Data Audit Trail Review
– M5 Data Auditing and Periodic Review
ISPE GAMP® Guide:
Records and Data Integrity
©2019 Waters Corporation 12COMPANY CONFIDENTIAL
e-Book
https://www.waters.com/waters/library.htm?lid=135029104&locale=101
©2019 Waters Corporation 14COMPANY CONFIDENTIAL
NuGenesis = SDMS + LMS + ELN + Inventories + Stability Module… SDMS = Scientific Data Management System
LMS = Laboratory Management System
ELN = Electronic Laboratory Notebook
NuGenesis?
©2019 Waters Corporation 15COMPANY CONFIDENTIAL
But Instrument Languages Differ?
Agilent - HPLC
Waters - UPLC/MS
вы говорите
по-русски?
Parlez-
vous
français?
Does anybody
speak a
common
language?!
Bruker - NMR MDC-FLIPR
Sprechen
Sie
Deutsch?
¿Habla
Español?
Shimadzu FTIR
00I0I0I00I0I
000I0I0II0I0I
0I00I00III0I0
0I00I0
Varian - CaryUV
©2019 Waters Corporation 16COMPANY CONFIDENTIAL
Labordaten
©2019 Waters Corporation 17COMPANY CONFIDENTIAL
Labordaten
©2019 Waters Corporation 18COMPANY CONFIDENTIAL
SDMS Oberfläche Volltextsuche
©2019 Waters Corporation 19COMPANY CONFIDENTIAL
Data Search / Filter Filter
©2019 Waters Corporation 20COMPANY CONFIDENTIAL
File Capture
©2019 Waters Corporation 21COMPANY CONFIDENTIAL
File/Data Import
Computer
SDMS
SDMS
©2019 Waters Corporation 22COMPANY CONFIDENTIAL
Messrechner
SDMS
SDMS
FileCapture
©2019 Waters Corporation 23COMPANY CONFIDENTIAL
MS Data in NuGenesis
©2019 Waters Corporation 24COMPANY CONFIDENTIAL
NuGenesis Patented Technology
Data Adaptors
NuGenesis Data Adaptors are a way of decoding common file types
– We have generic ones that fit all file types
– Plus some very specific ones including Empower and MassLynx
Vendor ProductWaters Corporation MassLynx & Empower
ABI-Sciex Analyst
Adobe Acrobat
Advanced Chemistry Development ACD SpecManager/ ChromManager
Agilent Technologies Agilent Chromatography ChemStation & Agilent ChemStore
BD Biosciences FACSDiVa
Bruker BioSpin XWIN-NMR & TopSpin
Bruker Daltonics XMASS
Dionex Chromeleon
MDL Isis Draw
Microsoft Microsoft Office
Perkin Elmer Turbochrom & TotalChrom
Shimadzu CLASS Agents
Thermo Finnigan Corporation Xcalibur
Thermo Fisher Scientific Atlas
©2019 Waters Corporation 25COMPANY CONFIDENTIAL
Keine Datenkonvetierung möglich?
©2019 Waters Corporation 26COMPANY CONFIDENTIAL
Print Capture
©2019 Waters Corporation 27COMPANY CONFIDENTIAL
How can a Report get into SDMS?
©2019 Waters Corporation 28COMPANY CONFIDENTIAL
Print Capture
SDMS
©2019 Waters Corporation 29COMPANY CONFIDENTIAL
Wie sieht so ein Report aus?
©2019 Waters Corporation 30COMPANY CONFIDENTIAL
Viewing Printed Data
Gel
Images
HPLC
Mass Spec
NMR
©2019 Waters Corporation 31COMPANY CONFIDENTIAL
Electronic Signatures
Annotate data
Apply e-Signatures
Bring control to data in one
single location
©2019 Waters Corporation 32COMPANY CONFIDENTIAL
Reuse Report Content
©2019 Waters Corporation 33COMPANY CONFIDENTIAL
Quantify Sample Report MassLynx 4.1
Dataset: C:\Daten\2006_003.PRO\intervetapciFges.qld
Signature: Not signed
Last Altered: Monday, March 13, 2006 18:38:30 Eastern Standard Time
Printed: At Monday, March 13, 2006 18:39:07 Eastern Standard Time
By WATERS-62X73KYU\Micromass (Mass Spectrometer Instrument)
Name: intervetapci060309055, Date: 10-Mar-2006, Time: 02:52:52, ID: , Description: F 5000
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
3.217e+006PMT
1.62
242364.91
2.42e5
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
329714
2022242
Sec.Area
242365
Response
329713.625
6.133
Detecti...
bb
bb
ng/g
1
4739
%Dev
16.3
-5.2
Ion Ratio
8.34
Name: intervetapci060309056, Date: 10-Mar-2006, Time: 03:01:01, ID: , Description: Acetonitril
ISTD
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
744.55 > 108.1
2.506e+0040.32
ISTD
1.62
935.58
9.36e2
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 98.1
1.042e+0050.32
PMT
1.62
3626.74
3.63e3
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
1.361e+0040.32
PMT
1.62
437.76
4.38e2
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
936
3627
Sec.Area
438
Response
935.577
3.876
Detecti...
bb
bd
ng/g
0
2993
%Dev
-99.7
Ion Ratio
8.28
Page 16 of 20
Reusing the Data in SDMS
No transcription or cut and paste or checking
Apply on printed reports with the same layout
Automation of calculations in destination document
Subject Analyte Value
1232-C1 CQ102 13,27
1232-C2 CQ102 14,89
1232-U1 CQ102 12,72
1232-U2 CQ102 13,04
1232-C3 CQ102 13,49
1232-U3 CQ102 14,13
Quantify Sample Report MassLynx 4.1
Dataset: C:\Daten\2006_003.PRO\intervetapciFges.qld
Signature: Not signed
Last Altered: Monday, March 13, 2006 18:38:30 Eastern Standard Time
Printed: At Monday, March 13, 2006 18:39:07 Eastern Standard Time
By WATERS-62X73KYU\Micromass (Mass Spectrometer Instrument)
Name: intervetapci060309055, Date: 10-Mar-2006, Time: 02:52:52, ID: , Description: F 5000
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
3.217e+006PMT
1.62
242364.91
2.42e5
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
329714
2022242
Sec.Area
242365
Response
329713.625
6.133
Detecti...
bb
bb
ng/g
1
4739
%Dev
16.3
-5.2
Ion Ratio
8.34
Name: intervetapci060309056, Date: 10-Mar-2006, Time: 03:01:01, ID: , Description: Acetonitril
ISTD
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
744.55 > 108.1
2.506e+0040.32
ISTD
1.62
935.58
9.36e2
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 98.1
1.042e+0050.32
PMT
1.62
3626.74
3.63e3
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
1.361e+0040.32
PMT
1.62
437.76
4.38e2
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
936
3627
Sec.Area
438
Response
935.577
3.876
Detecti...
bb
bd
ng/g
0
2993
%Dev
-99.7
Ion Ratio
8.28
Page 16 of 20
Quantify Sample Report MassLynx 4.1
Dataset: C:\Daten\2006_003.PRO\intervetapciFges.qld
Signature: Not signed
Last Altered: Monday, March 13, 2006 18:38:30 Eastern Standard Time
Printed: At Monday, March 13, 2006 18:39:07 Eastern Standard Time
By WATERS-62X73KYU\Micromass (Mass Spectrometer Instrument)
Name: intervetapci060309055, Date: 10-Mar-2006, Time: 02:52:52, ID: , Description: F 5000
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
3.217e+006PMT
1.62
242364.91
2.42e5
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
329714
2022242
Sec.Area
242365
Response
329713.625
6.133
Detecti...
bb
bb
ng/g
1
4739
%Dev
16.3
-5.2
Ion Ratio
8.34
Name: intervetapci060309056, Date: 10-Mar-2006, Time: 03:01:01, ID: , Description: Acetonitril
ISTD
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
744.55 > 108.1
2.506e+0040.32
ISTD
1.62
935.58
9.36e2
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 98.1
1.042e+0050.32
PMT
1.62
3626.74
3.63e3
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
1.361e+0040.32
PMT
1.62
437.76
4.38e2
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
936
3627
Sec.Area
438
Response
935.577
3.876
Detecti...
bb
bd
ng/g
0
2993
%Dev
-99.7
Ion Ratio
8.28
Page 16 of 20
Quantify Sample Report MassLynx 4.1
Dataset: C:\Daten\2006_003.PRO\intervetapciFges.qld
Signature: Not signed
Last Altered: Monday, March 13, 2006 18:38:30 Eastern Standard Time
Printed: At Monday, March 13, 2006 18:39:07 Eastern Standard Time
By WATERS-62X73KYU\Micromass (Mass Spectrometer Instrument)
Name: intervetapci060309055, Date: 10-Mar-2006, Time: 02:52:52, ID: , Description: F 5000
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
3.217e+006PMT
1.62
242364.91
2.42e5
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
329714
2022242
Sec.Area
242365
Response
329713.625
6.133
Detecti...
bb
bb
ng/g
1
4739
%Dev
16.3
-5.2
Ion Ratio
8.34
Name: intervetapci060309056, Date: 10-Mar-2006, Time: 03:01:01, ID: , Description: Acetonitril
ISTD
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
744.55 > 108.1
2.506e+0040.32
ISTD
1.62
935.58
9.36e2
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 98.1
1.042e+0050.32
PMT
1.62
3626.74
3.63e3
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
1.361e+0040.32
PMT
1.62
437.76
4.38e2
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
936
3627
Sec.Area
438
Response
935.577
3.876
Detecti...
bb
bd
ng/g
0
2993
%Dev
-99.7
Ion Ratio
8.28
Page 16 of 20
Quantify Sample Report MassLynx 4.1
Dataset: C:\Daten\2006_003.PRO\intervetapciFges.qld
Signature: Not signed
Last Altered: Monday, March 13, 2006 18:38:30 Eastern Standard Time
Printed: At Monday, March 13, 2006 18:39:07 Eastern Standard Time
By WATERS-62X73KYU\Micromass (Mass Spectrometer Instrument)
Name: intervetapci060309055, Date: 10-Mar-2006, Time: 02:52:52, ID: , Description: F 5000
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
3.217e+006PMT
1.62
242364.91
2.42e5
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
329714
2022242
Sec.Area
242365
Response
329713.625
6.133
Detecti...
bb
bb
ng/g
1
4739
%Dev
16.3
-5.2
Ion Ratio
8.34
Name: intervetapci060309056, Date: 10-Mar-2006, Time: 03:01:01, ID: , Description: Acetonitril
ISTD
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
744.55 > 108.1
2.506e+0040.32
ISTD
1.62
935.58
9.36e2
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 98.1
1.042e+0050.32
PMT
1.62
3626.74
3.63e3
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
1.361e+0040.32
PMT
1.62
437.76
4.38e2
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
936
3627
Sec.Area
438
Response
935.577
3.876
Detecti...
bb
bd
ng/g
0
2993
%Dev
-99.7
Ion Ratio
8.28
Page 16 of 20
Quantify Sample Report MassLynx 4.1
Dataset: C:\Daten\2006_003.PRO\intervetapciFges.qld
Signature: Not signed
Last Altered: Monday, March 13, 2006 18:38:30 Eastern Standard Time
Printed: At Monday, March 13, 2006 18:39:07 Eastern Standard Time
By WATERS-62X73KYU\Micromass (Mass Spectrometer Instrument)
Name: intervetapci060309055, Date: 10-Mar-2006, Time: 02:52:52, ID: , Description: F 5000
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
3.217e+006PMT
1.62
242364.91
2.42e5
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
329714
2022242
Sec.Area
242365
Response
329713.625
6.133
Detecti...
bb
bb
ng/g
1
4739
%Dev
16.3
-5.2
Ion Ratio
8.34
Name: intervetapci060309056, Date: 10-Mar-2006, Time: 03:01:01, ID: , Description: Acetonitril
ISTD
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
744.55 > 108.1
2.506e+0040.32
ISTD
1.62
935.58
9.36e2
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 98.1
1.042e+0050.32
PMT
1.62
3626.74
3.63e3
PMT
min
2.00 4.00
%
0
100
F1:MRM of 3 channels,AP+
734.55 > 174.1
1.361e+0040.32
PMT
1.62
437.76
4.38e2
1
2
#
1
2
Name
ISTD
PMT
RT
1.62
1.62
Area
936
3627
Sec.Area
438
Response
935.577
3.876
Detecti...
bb
bd
ng/g
0
2993
%Dev
-99.7
Ion Ratio
8.28
Page 16 of 20
Average 13.59
©2019 Waters Corporation 34COMPANY CONFIDENTIAL
Data Management
Data Retention can be Enabled on a Project
Flexible Retention Policies
Complete Manual or Automatic Deletion After Expiration
Legal Holds will Prevent Any Change or Deletion
©2019 Waters Corporation 35COMPANY CONFIDENTIAL
©2019 Waters Corporation 36COMPANY CONFIDENTIAL
Password Protection
©2019 Waters Corporation 37COMPANY CONFIDENTIAL
The missing Compliance Tab
https://www.linkedin.com/feed/update/urn:li:activity:6328289080425746432
©2019 Waters Corporation 38COMPANY CONFIDENTIAL
NuGenesis: Excel Remediation
©2019 Waters Corporation 39COMPANY CONFIDENTIAL
Summary
NuGenesis LMS takes care of
– File Capture
– Print Capture
– Excel Remediation
– Automated data archival and deletion
– Report distribution and e-Signature review
– Audit trail management
– Minimising transcription errors
– Minimising or eliminating review
– Increase laboratory productive and meets regulatory and accrediation bodies expectations on records control
But it doesn‘t stop there...
Data
Management
Sample/Test
Management
Stability
Management
Paperless
Laboratory
Inventory
Management
©2019 Waters Corporation 40COMPANY CONFIDENTIAL
( )
Weitere Informationen
Excel RemediationNuGenesis SDMSVitaQuest
Case Study (183% ROI)
©2019 Waters Corporation 41COMPANY CONFIDENTIAL
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