Nuclear receptorsNuclear receptors

Emilie Lilford

Group 11

Biochemical definition of a receptor

Chemical change physiological change biological function

LigandLigand

ReceptorReceptor

Types of receptors and locations:• Cell surface receptors • Receptors located in the cytoplasm• Nuclear receptors Nuclear receptors

Ligands of nuclear receptors

Structures of some nuclear receptor ligands and their corresponding receptors name.

Structural organization

Sandwich filling model of ligand binding domain (LBDLBD)

DNA binding domain (DBDDBD) – structure of the human progesterone receptor

What is a Domain?

• Independent subunits of proteins.• Between 25 -500 amino acids in length. • Independently stable and folded.• Can diverge and converge.• Domain represents function. Domain represents function.

Domains of nuclear receptors

• Zinc fingers• LBD• DBD • N-terminal + C-terminal

How nuclear receptors work.