NTP Radioisotopes SOC LtdA subsidiary of Necsa Ltd

Pelindaba, South Africa

NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY AND COOPERATION WITH BELGIUM

www.ntp.co.za

Mapula Letsoalo2013 October 23

Depleted Uranium Fabrication Facility (Pelindaba)

Contents

• Role in global Mo-99 supply

• Role in SA nuclear medicine

• Continued relations with IRE

NTP Radioisotopes (Pty) Ltd

Pretoria

Johannesburg

Soweto

OR Tambo

NTP located at the Necsa Pelindaba Site

Geographical Location of NTP RadioisotopesGeographical Location of NTP Radioisotopes

In 1991, the South African

government signed the

Non-Proliferation Treaty (NPT)

and became the first and only

nation to voluntarily declare and

dismantle its nuclear weapons

And they shall beat their swords

into ploughshares ... – Isaiah 2:4

The Real And Lasting Victories Are Those Of Peace

12

34

5

1 - Radiochemical Production Plant2 - Commercial Office3 - Radiopharmaceutical Production Plant4 - Radioanalytical Labs5 - SAFARI-1

Mo-99 Production & Related Facilities

SAFARI-1 Nuclear ReactorSAFARI-1 Reactor

Mo-99 Production at NTP

Radiochemical Production PlantChemical Extraction and purification of Mo-99

Waste Disposal & Storage Facilities

NTP Generator Manufacture

Transport Container DesignManufacture, License

Local & International Users

Nuclear Waste Management

DepletedUranium

Inventory

International Market

Waste

Irradiated plates

Target Plates

Nuclear Fuel AssembliesFuel Production

Plant

Enriched UraniumInventory

Mo-99 Production at NTPSAFARI-1 ReactorTarget Plate Irradiation

NTP Product Portfolio

• Collaborative partnership since 1997

• Mo-99 Supply crisis

• Increased production output

NTP - IRE Cooperation

ARI5% NTP

40%

Covidien25%

IRE30%

Mo-99 Supply - Crisis Conditions

Total: 8 000 Ci/week

Radiochemical Transport Containers (1 500 Ci Mo-99, 125kg)

Depleted uranium fabrication facility

Radioisotope Source ContainersRadioisotope Source Containers

Subsidiary Companies

NTP Logistics is a joint venture company

between NTP Radioisotopes (51 %) and a

BEE partner

Specialize in managing the logistics of

dangerous goods including radioactive

materials.

Subsidiary Company

NTP Product PortfolioConversion of Mo-99 Production to LEU

2007• Theoretical feasibility studies

2008• Cold and depleted uranium experiments

2009• NNR approval received for test stage• Hot runs commence

2010• Submission to Regulators (June)• Validation runs (July)• NNR approval routiine ops (Sept)• FDA approval for use in US (Nov)

2011• Routine supply of LEU Mo-99 (June)

Medical Facility

1

2

3

1 - Medicals & Industrials2 - SAFARI-13 - Cyclotron facility

Medicals Facilities

1

2

3

Radiopharmaceuticals

NovaTec-P Tc-99m Generator, Cold kits

F-18 FDG

I-131 Capsules, Solution and MIBG

New

Lu-177 dotatate

F-Choline

PET-CT Image

Nuclear Medical Isotopes & Related ProductsRadiopharmaceuticals

Subsidiary Companies

NTP has a 100% shareholding in AEC-

Amersham SOC Ltd

Exclusive distributor in Africa of NTP's

radiopharmaceutical products as well as

a range of life science research and other

products.

Subsidiary Company

Corporate Social Investment

PET/CT Scanner donated to people of

Western Cape

Located at Tygerberg PET/CT Centre

Official opening - April 2012

Subsidiary CompaniesSubsidiary Company

Fully-owned subsidiary company NTP Radioisotopes (Europe) S.A.

Established on 1 February 2013

Located in Belgium – IRE site

Manufacturer and distributor of gamma-radiography equipment used in the non-

destructive testing (NDT) industry, including sealed radioactive sources containing Ir-

192, Se-75 and Co-60, as well as the GammaMat range of NDT projectors and

accessories

Also manufactures a range of Ir-192 brachytherapy products

Subsidiary CompaniesConclusion

Necsa/ NTP’s nuclear technology is making a major contribution to the economy

and to our country’s global standing.

Subsidiary CompaniesThank you very much!