NIH ecor U. S. DEPARTMENT OF

HEALTH, EDUCATION, ANO WELFARE November 6, 1973 Vol. XXV, No. 23 NATIONAL INSTITUTES OF HEALTH

Dr. E. Driscoll Named NIDR Clinical Director

U.5.-Soviet Symposium On Heart Disease Held

Unique Structure of Subtilin Established; Chemists Compare It to Nisin Molecule

Dr. Driscoll's research contributians have earned him the Heidbrink and the Horace Wells Club Awards in anesthesiology and an HEW Superior Performance Award.

An Office of the ,Clinical Direc­tor and two new branches have been established within the intra­mural programs of the National Institute of Dental Research.

Dr. Edward J. Driscoll was named clinical direct.or, with re­sponsibility for NIDR in-patient investigations in the Clinical Cen-

t ter as well as out-patient studies \ conducted in the Dental Clinic.

Provides Routine Care

Routine dental care is also pro­vided patients of other Institutes in the OC.

Among the posts held by Dr. \ Driscoll since joining the NIDR

staff in 19'54 are: chief of the Clinical Investigations Branch, as­sociate director for Extramural Programs, and chief of the Anes­thesiology Section of the Oral Med­icine and Surgery Branch.

Research Interest Described

His major research interest is physiology as it pertains to anes­thesia, both local and general, in the ambulat,ory dental patient.

Within the clinical director's of­fice, Dr. Richard L. Webber will serve as chief of the Clinical In­vestigations and Research Services Branch, and Dr. Ronald Dubner will head the Neurophysiology and Anesthesiology Branch.

The U.S.-U,S.S.R. Symposium on Myocardial Metabolism and Function, sponsored by the Na­tional Heart and Lung Institute, is being held Nov. 4-6 at Ponte Vedra Beach, Fla.

THE STRUCTURE OF NISIN AND SUBTILIN

The Symposium has brought t.o­gether 25 Soviet and American ex­perts on cardiovascular diseases.

Sign Agreement in 1972 The U.S.-U.S.S.R. Cooperative

Health Program on Disease, a 5-year agreement signed in 1972, provides for scientific cooper,ation between the two countries in at­tacking problems of mutual con­cern in the areas of cardiovascular disease, cancer, and environmental health.

OHA = o,nvd,oa1aniM COOH

Chairmen of this latest symposi­um are Dr. Eugene I. Chazov, Deputy Minister, Ministry of Health of the U.S.S.R., Moscow, and Dr. Eugene Braunwald, Physi­cian-in-Chief, Peter Bent Brigham Hospital and Hersey Professor of Theory and Prac.-tice of Physic, Harvard Medical School.

ALA- S - ALA ~ L.lnthtClnin• ABA-S-ALA :t fJ -MathyflanthliOnln.•

The structure of subtilin, a polypeptide antibiotic produced by Bacillus -~nhtllls, has been elucidated by chemists at the National Institute of Child Health and Human Development.

Following the structural determination of nisin from Strcptooooou8

Dr. Cooper Participates NHL! Director, Dr. Theodore

Cooper, is one of the American participants in the symposium.

Topics discussed during the 3-day meeting include: mechanisms by which the heart adjusts t,o over­loads; protein metabolism in the normal and failing heart; calcium uptake processes in the heart; ef-

( See HEART JTE/i!TTXG, ['(lye.\)

laotia 2 yen rs ago in aollu boration w1th John T,. )forrell, (see the NIH Record, Sept. 28, 1971) . D,-.s. Erhanl Gross, Hans Hermann Kiltz, and Eike Nebelin have found similar unique structural features in the subtilin molecule.

Dr. GOC'Oss is chief of the Section on Molecular Structure in the Re­production Research Branch.

Some of the structural features of subtilin led Dr. Gross and his

Three chiefs hove recently been appointed ta head branches in the National Cancer lnstitute's Division of Cancer Research Resources and Centers (formerly the Division of Cancer Grants). Dr. Samuel Price (I) has been named chief of the National Organ Site Program Branch in the Office of the Associate Director for Research Programs. Dr. Mordecai H. Gordon (c) is now serving as chief of the Review and Refe rral Branch in the Office of the Division Director, and Harry Y. Canter wos appointed chief of the Program Analysis and Evaluation Branch in the Office of the Associate Di,ector for Pro~ram Planning.

co-workers to postulate certain biological aciivitic,s for nisin and subtilin, for instance, interaction with important sulfhydryl groups on membranes and in the cell.

When tested, nisin and several of its fragments released enzymes from lysosomes, particles vital for the proper functioning of the cell.

Since nisin induced resorption of the fetuses of r ats and rabbits, its effect on cancer tissue is now being studied in collaboration with the Cancer Chemotherapy Pro­gram of the National Cancer Insti­tute.

Amino Aids Rarely Seen

Eight of the amino acids of sUib­tilin are of unusual structure rare­ly seen in nature, and then almost always in microorganisms.

The rare amino acids are lanthi­onine and beta-methyllanthionine and two alpha, beta-unsaturated amino acids, dehydroalanine and dehydrobutyrine.

The lanthionines may have been formed in the microorganism by the addition of sulfhydcyl groups across the double ·bonds of alpha, beta-unsaturated amino acids.

The comparison of nisin and sU:b­(See SlilJ7'1Ll N, Page 6)

Page 2 November 6, 1973

Published biweekly at Bethesda, Md., by the Publications and Reports Branch, Office of. Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­gators in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on r equest. The NIH Record reserves the right to make corrections, changes or dele­tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare.

NIH Record Office ....... .. .. ...... ..... ... . .. Bldg. 31, Rm. 2B-03. Phone 49-62125

Editor . . ..... .. .... . ... .... .. . ... ..... .. .. ............ ... ........ .. ... .. .............. Fronces W. Davis Assistant Editor . . .... , .......... ... ............ .. .. ........ .......... . ....... .. .. ... .. ... Fay Leviero Stoff Writer ... . . .... . . ... ........................ ... ........ .... ...... .. ............. . ..... Ed Driscoll

Stoff Correspondents ADA, Melissa Howard; OC, Thalia Roland; DCRT, Joan Chase; DRG, Sue Meadows; DRR, Jerry Gordon; DRS, Cora M. Sult; FIC, Lois P. Meng; NCI, Carolann Hooton; NEI, Bonnie Friedman; NHLI, Bill Sanders; NIAID, Krin Larson; NIAMDD, Pat Gorman; NICHD, Ka,thy Kowalczyk; NIDR, Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS, Wanda Warddell; NINDS, Carolyn Holstein; NLM, Ruth E. Armstrong.

Patient Emergency Fund-Via Davis Plan­Offers Financial Assistance for Necessities

Last year nearly $31,000 was needed to help Clinfoal Center pa­tients during financial emergencies that are not covered by Federal funds.

Because of th e OC's P111trlent Emergency Fund, the monetary assistance was made availa,ble­and the Davis Plan contributed m<>i'e than a quarter of PEF's in­come.

Donations Voh,ntory The :fund is supported by volun­

tary donations from NIH employ­ees and others, including OC pa­tients.

The Davis Plan was started by

Dr. Miguel A. Rodriguez, Center for Biomedicol Information, Ministry of Health ond Welfare in Mexico, is a participant in a special progrom for the exchange of young technicions be­tween Mexico and the U.S. Dr. Rodri­guez, who is ot the Notional Librory of Medicine, will observe and olso take port in vorious N LM opero~ions, The speciol program is sponsared by the U.S. Deportment of $tote and the Mexicon National Coun~II fqr Scie11ce ond Technology.

James B. Davis, Directnr of the Office o:f Administi-ative Services, who made a donation to the fund in lieu of sending Christmas cards to his co-workers. The idea spread and soon many NIH employees were following Mr. Davis' plan.

Bai,bl!J'a A. Murphy, chief, OC Social Work Department, stated that recently more patients with low incomes or who are unemploy­ed have 'been admitted to the OC; many have had expensive long­term medical care before arriving here. Funds Used for Board

The primary need, last year, for PEF funds was for room and 'board to enable out-of-town relatives to stay in Bethesda while patients were critically ill.

Other fund expenditures pro­vided special programs such as birthday parties for patients or ex­peditions to local events. The fund was also used to enable patients to make long-distance calls, and for clothing and special devices.

Small weekly allowances from the fund permitted some patients to purchase basic necessities such as shaving equipment.

Ms. Murphy termed the Davis Plan as essential to the PEF pro­gram, and ui,ged that contributions to the fund should be made during the holiday season.

FAES String Quartet Concert Scheduled for Sunday, Nov. 18

The second concert in the 1973-74 Chamber Music Series of the Foundation for Advanced Educa­tion in the Sciences will feature the Tokyo String Quartet.

The concert; wjll be pre11ented in

Open Season for Health Benefits Starts Nov. 15

An "Open Season" for the Fed­eral Employees Health Benefits Program will start on Nov. 15 and end on Nov. 30.

Eligible employees may register to enroll in a plrui. Those already enrolled may change their plan, option, type of enrollment, or any combination of these. Ohan~s from family to self-only coverage may be made at any time.

NIH employees may enroll in one of nine different plans. The three general plans a r e Group Health Association Plrui of Wash­ing.ton, D.C., Indemnity Benefit Plan (Aetna Life and Casualty Company) and Service Benefit Plan (Blue Cross-Blue Shield).

Other Plons Nomed

The other plans are: American Federal of Government Employees Health Benefit Plan, Alliance Health Benefit Plan, American Postal Workers Union Plan, Gov­ernment Employees Hospital AJ.­sociation Benefit Plan and Mail Handlers Benefit Plan. In order to enroll in one of these plans, an employee must become a member of the sponsoring organization.

Employees living in the sur­ro·unding Columbia, Md. area, may enroll in the local comprehensive medical plan, the Columbia Medi­cal Plan of Columbia, Maryland.

Desk-to-Pesk Distribution Next week, a desk-to-desk dis­

tribution of a packet, entitled In­formation on Federal Employees Health Benefits Program, will be made. Revised brochures on the three major plans, biweekly prem­ium rates for all plans, and regis­tration procedures will be in­cluded.

Brochures for the other six plans may be obtained in Bt l/D per­sonnel offices.

All of the plans have changes in benefits which are itemized in the 197 4 brochure. Assistants Give Help

During the Open Season, regis­tration assistants will help em­ployees complete forms and answer questions. Their names and loca­tions will be on official bulletin boards and in personnel offices.

A panel of experui from the three major health plans will an­swer questions on the 1974 con­tracts on Monday, Nov. 19, at 9 a.m. in Bldg. 1, Wilson Hall. The session, open to all NIH em­ployees, is sponsored by the Em­ployee Relations and Recognition Branch, OPM.

the Jack Masur Auditorium on Sunday, Nov. 18, at 4 p.m.

The program will include select­ed works by Haydn, Bar:tok, and Beethoven.

Admission is by ticket only.

THE NIB RECORD

RATES New rates become effective

on Jan. 6, 1974. GROUP HEAL TH ASSOCIATION

OF WASHINGTON, D.C. 1913 1914

f>elf High option $ 8.22 $ 7.87 Low option 4.68 4.36

v'ami/JJ High option 21.10 20.34 Low option 12.43 11.67 INDEMNITY BENEFIT PLAN

(Aetno) Self

High option 5.26 6.13 Low option 2.54 2.98

r.'amily High option 12.88 15.24 Low option 6.08 7.38

Self

SERVICE BENEFIT PLAN (Blue Cross- Blue Shield)

High option 5.91 7.49 Low option 2.04 2.04

Family High option 14.11 18.04 Low option 4.99 4.99

CFC Reaches Its Last Reporting Date; Prize Drawing to Be Held

NIH employees have signed pledges tot aling $183,885 toward the Combined Federal Campaign goal of $264,000. This amounts to 70 percent of NIH's goal, with 37 • percent of our employees partici­pating.

Only one reporting period, Nov. 6, remains before the campaign concludes.

The following organizations have exceeded their dollar goal: FIC, DRG, NLM, NIGMS, DRR, DRS, NIDR, NIAMDD, and OD/ ODA.

All employees who participated in the campaign are invited to at­tend a prize drawing ceremony in the main lo.bby of Bldg. 31 on Mon­day, Nov. 12, at 1 p.m.

Gift certificates totaling $100, r e­deemable at any Recreation and Welfare Center, will be awarded. To be eligible, employees must have contributed to the CFC and submitted their ticket to their key­men, who must in turn send all tickets to CFC Headquarters in the National Library of Medicine by Nov. 9.

Employees Invited to Hear Tape of Dr. Mead's Lecture

NIH'ers are invited to listen to a tape recording of Dr. Margaret Mead's lecture on "The Changing Significance of Territoriality in Humrui Socie­ties." It will be played at noon on Nov. 18, 14, and 15 in Bldg. 31, Room B2C12.

The recording lasts one and one-half ho11rs.

THE NIH RECORD November 6, 1973

Otis Watts, Deputy EEO Officer, Came Up Hard Way-From Ranks to Lt. Col.

A private who rose from the ranks to lieutenant colonel has been appointed Deputy EEO Officer at NIH. He is Otis D. Watts, turned civilian, and he now says, "Call me Mr. or Otis."

Dr. Marshall W. Nirenberg, chief of the Laboratory of Biochemical Genet­ics, National Heart and Lung Institute, rec:ently rec:eived on honorary doc:tor­ate in medic:ine from the University of Pavia in Milan. The award was pre­sented b) Prof. Antonio Fornari, rec:• tor of the University. Dr. Nirenberg, who shared the 1968 Nobel Prize ,., Physiology, was c:ited for "special mer­its in the biologic:al scienc:es."

NLM WUI Host Medical History Society Meeting

The Washington Society for the History of Medicine will hold its next meeting on Thursday, Nov. 15, at 8 p.m. in the Billings Audi­torium of the National Llbrary of Medicine.

The program will include dis­cussions on The Lousy Adventure of Fred L. Soper, 1943-1944, by Dr. J. Austin Kerr, and American Medical Science and the Introduc­tion of the Microscope 1830-1860 by NLM'•s Dr. James H. Cassedy.

Refreshments will be served in recognition of Dr. Soper's ap­proaching 80th birthday.

Visitors are welcome.

Mr. Watts came to NIH--after a 7-month hiatus-from Headquar­ters, First United States Army at Fort Meade. There, he was direc­tor of Equality Programs which included EEO for more than 34,000 civilians, and Equal Opportunity­Race Relations for more than 250,-000 military personnel both active and in the reserves.

That period from March until his appointment here in October, was not spent on what justifiably might have been a well-earned 'Va­cation. In.stead, he was doing grad­uate research on race relations for his master's thesis which he ex­pects to finish early in the new year.

He will receive his graduate de­gree from Southern Illinois Uni­versity. That midwest school has a branch in Washington, D.C. for its graduate program.

"We meet for two 3-day sessions -Friday, Saturday and Sunday­twice during the academic quarter. There are about 5 weeks between sessions for reading and research," Mr. Watts said.

Advocote of Educ:otion He is an advocate of learning

while in uniform, and explained that every military installation "has a couple of colleges conduct­ing comses toward a degree.

"I could use myself as an ex­ample," he said. "I got my under­graduate degree in 1967 at the University of Maryland, European Division in ~any, and now I'm a candidate for an M.A.

Send in Update Forms for Directo·ry Ustings 1f your name was omitted from the lrutest NIH 'l'elephone anrl Serv­

ice Diffector11, don·t panic. You are not "inoperative." Someone simply forgot to submit GPO Form 433 to the Directory Unit.

When an employee transfers, resigns, etc., his administrative officer is responsible for updating the telephone listing.

Form 43:J is available at self-service stores and should be sent to the Telephone and Service Directory Unit, Bldg. 10, Room B1A33.

For ijnfonnation, consult diredive 1765-2 in thl• NJil Man11al.

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Mr. Watts cited facts and figures whic:h showed the inc:rease of blac:k officers in the U.S. Army.

"Ii a man wants an education on active duty he can take courses leading to advanced degrees. I went to the university five nights a week."

Served in Germony, Far East

Besides two tours in Germany, Mr. Watts also served in Korea and Viet Nam. He went on to dis­cuss race relations in the service, and pointed out that "the military was the first to desegrega,te as an institution.

" In 1962, there were no -black generals in the U.S. Army, there were only about six colonels and approximately 60 lieutenant col­onels. Today there are about 14 black generals in the Anny and more than 50 full colonels and at least a couple of hundred lieuten­ant colonels-now, there's a very good chance of a black private get­ting to be a general."

Meons Hard Work

He clarified this by saying, "It does mean hard work and getting an education. I don't t hink any­one can advance to a general today ,vithout an education, but there's an opportunity to do this while in uniform."

Coming back to his work at NIH, Mx. Watts, who is fully con­versant with all areas of EEO, said that here he will be particu­larly interested in one aspect-­"compliance."

"I will monitor the canying out of decisions on discrimination com­plaints," he stated.

Mr. Watts, a native Georgian, completed high school there, and also attended Fort Valley .State College for one year, before he ·was drafted into the Arl)'ly during the Korean War.

He has a wife and three chil­dren-two girls and a boy. There

Page 3

Safety Tips for NIH Observance of simple precau­

tions will reduce compressed gas cylinder hazards:

1. Chain or strap cylinders se­curely during storage and use.

2. Transport cylinders only on a cylinder truck with retaining strap secured.

3. Cap the valve during storage, transport, and handling.

4. Store cylinders in an exterior location to avoid fire hazards.

5. Store and use cylinders in· well-ventilated areas away from sources of heat.

For additional information, con­sult th e NIH Compressed Gas Guide available from the Safety Office, Ext. 65270.

GAS CYUN~RS NfEDTLC

Dr. Vivi.an, Forme·r NCI Chem'ist, Dies in Tucson

Dr. Donald L. Vivian, who had been with the National Cancer In­stitute from 1947 to 1959, died re­cently in Tucson, Ariz.

Dr. Vivian was a research chem­ist in the Organic Chemistry Sec­tion, Laboratory of Chemical Phar­macology.

For the past 12 years he had served as professor of pharmaceu­tical chemistry at the University of Arizona's College of Pharmacy.

Dr. Vivian was the author of many papel1S on phenazine chem­istry, and held several patents on drugs used for the treatment of tlllllors.

Hii! work at NCI and at the University of Arizona included the development of compounds used for testing in tumor-bearing ani­mals. He is survived by his wife Sally.

are photographs in his office of Mrs. Watts and 2 children at his retirement party which was at­tended by officers wearing such in­signia as stars, eagles, oakleaves and bars.

Asked where his third child was, Mr. Watts answered, "behind my wife's dress, my latest little girl was born 5 months ago."

Page 4 November 6, 1973

CC nurse Ruth Estabrook (c ) stands near a donor wha is g1v1ng white blood cells while NCI technician Fronk :;tout (I) operates the blood ce ll separator. In the foreground, head nurse Regina Dowling checks a plate let donor wha is comfortably reading a book during tho process.

A conferencc on the procedures of plasmapheresis, a relatively new technique for obtaining large quantities of blood components, was recently presented by the Clini~al Center )rursing Department plasma­pheresis staff.

'!'he conference, entitled Nurses' Role in Blood Component Trans­fusion Procurement, acquainted nurses at the CC and other a,rea hospitals with the specialized blood collecting techniques and nursing care of donors.

Participants Listed

P articipants included Eileen Jones, supervisory nurse in the plasmapheresis laboratory, head nurse Regina Dowling, and clinical nurses Ruth Estabrook and Louise Osborne.

Large amounts of white blood cells and platelets from selected donors are needed at the CC for certain patients with hemorrhagic or immune deficiency diseases.

Using traditional <blood separa­tion methods, several donors would have been essential for procuring white blood cells for one transfu­sion.

One Donor Is Enough

However, with a continuous flow blood cell .separator developed by NIH and IBM, one donor can pro­vide th e necessary white blood cells.

Using the separator, blood is drawn, components removed, and the rest returned immediately to the donor.

By this method, enough white blood cells for a CC patient can be obtained in 4 hours without danger to the donor. Up to 4 units of platelets may be obtained at the same time as the white blood cells.

Platelets may also be obtained

separately by another procedure: A unit of blood is separated by

centrifugation into platelet-rich plasma and red blood cells. The cells are returned to the donor immediately.

Then the platelets are extracted .from the plasma and t he plasma is returned also. This process is repeated 4 times during the 2 ½ hour procedure.

First Performed in 1960 Plasmapheresis was first per­

formed at the Clinical Center in 1960- the current la1boratory was founded in 1964. That year, 100 blood cell separation procedures were performed. This year, the total will be 1,116.

Healthy people who have the same blood type and histocompati­bility (HL-A) antigens as the pa­tient are selected as donors.

HL-A antigens are proteins on the surface of white blood cells. The chance of 'finding two unrelat­ed individuals with the same HL-A antigens is 1 in 4,725. For rare types, the chance is 1 in 10,000.

Major Complaint- Boredom

The nurses reported that poten­tial plasmapheresis donors receive extensive physical examinations. White blood cell donors are ad­mitted to the CC as outpatients. Platelet donors may also be ad­mitted as outpatients.

Although the procedure is com­plicat.cd and lengthy, the nurses said the major donor complaint is boredom-white blood cell donors

Digestive Diseases Br. Creates New Section, Realigns Three Others

Three clinical sections have been realigned and a new section estab­lished in the Digestive Diseases Branch of the National Institute of Arthritis, Metabolism, and Digestive Diseases.

The changes were made to r e­flect current activities in gastro­enterology research, an area of re­cently intensified interest in the Institute.

Dr . Robert S. Gordon, NI AMDD clinical director, has been named chief of the Digestive Diseases Branch, formerly the Digestive and Hereditary Diseases Branch.

The new branch is composed of four sections, including a new sec­tion of Gastroenterology, headed by Dr. Jerry Gardner.

Future Studies Outlined

The gastroenterology section \vill investigate the pathology of disease in the gastrointestinal tract and examine hormonal con­trol of gastrointestinal func.-tion.

It will also be responsible for studies on the mechanism of tr ans­port of electrolytes and nutrients particularly with reference to the G.I. tract, and the effects of toxic substances on these processes.

The other three sections trans­ferred from the Metabolic Diseases Branch include the sect ion on Diseases of the Liver, directed by Dr. Paul Berk; the Phoenix Clini­cal Reseaorch section, with Dr. Peter Bennett as acting chief, and the section on Physiology and Clinical Nutrition, also under the direction of Dr. Gordon.

Dr. Gerald Aurbach will replace Dr. Gordon as chief of the Metabolic Diseases Branch.

must keep both ,arms still through­out the procedure.

Afterward a cup of orange juice and a few minutes' rest ar e all that is usually necessary before the donors may return to norm.al activity.

The nursing staff stated that a majority of donors volunteer to return as often as needed to help OC patients. They find the plasma­phcresis process an interesting and rewarding experience.

Program Needs Contributors Blood component contribu­

tors aire needed. Employees who are interested in partici­pating in the plasmapheresis program may call 496-202,2 and leave their name and tele­phone number with the re­corded answering service.

Callers who are blood donors at the CC Blood Bank should indicate this to the answering service as their HlL-A type may already be known.

THE NIH RECORD

Dr. Schwartz Appointed Assioc. Dir. for Review, NHLI Extramural Affairs

Dr. Samuel M. Schwartz has been ,appointed associate director for Review and chief of the Re- 1

view Branch in the National He,art and Lung Institute's Division of Extramural Affairs.

In his new post, Dr. Schwartz will review and evaluate applica­tions for research or training sup­port under a number of NHLI programs concerned with heart , and blood vessel disease, lung dis­eases, blood diseases and re­sources.

Education Noted

These include research and de­velopment cont racts, and grants f o r -Specialized Cen.ters of Re­search, Program Projects, Pulmon­ary Academic Awards, Young In­vestigators Pulmonar y Research, and Research and Demonstration Centers.

Dr. Schwartz received his B.S. from the University of Manitoba, and his Ph.D. from the University of Minnesota in 1956

He then taught at George Wash­ington University until 1964, when he came to NIH. During this period he was also a consultant on research and development for the Crane Rall Corpora,tion and the Burton P arsons Company.

Before his latest appointment, i:.'r. Schwartz has held posts with the No­tional Cancer Institute, the Division of Research Grants, and the Nationol Eye Institute.

HEART MEETING ( Continuc,l t,·om Page 1)

fects of drugs and hormones on cardiac metabolism and the regula­tion of heartbeat, and the effects of blood and oxygen deprivation on heart muscle.

Dr. Chazov and the five Soviet participants in the Symposium vis­ited NHLI for 2 days prior to the meeting. They plan to visit several other U.S. cardiovascular research centers before returning to the U.S.S,R. on Nov. 18.

Proceedings of the meeting will be puiblished in both English and Russian. The English version will be printed as a supplement to Oirculatfo,i R('8earch.

I

THE NIH RECORD

Dr. Robert Goldberger Named to NCI Post

November 6, 1973

Dr. Robert F. Goldberger was recently appointed chief of NCI's Laboratory of Biochemistry, Divi­

, sion of Cancer Biology and Diag-

Dr. M. Mead Tells Overflow Audience About Change in Area of Competition

nosis. Dr. Goldberger

served as a bio­chemist in the L a b o r a t o ry of Chemical Biology, NIAMD, from 1963 until 1 9 6 6 when he became head of the Bio­synthesis and Con­trol Section, a po-

Dr. Goldberge r sition he held until his transfer to NCI.

Dr. Goldberger graduated from Harvard College in l!l54 and the New York University School of Medicine in 1958.

In 1961, after 2 years as a post­doctoral trainee at the Institute for Enzyme Research of the Uni­versity of Wisconsin, he joined NHLI as a research associaite. Dur­ing 1963 he was a visiting scien­tist at the Weizmann Institute of Scienoe in Israel.

Dr. Goldberger has authored more than 50 original papers in the fields of biochemistr~·, molecu­lar biology, and biochemical gene­tics. In 1973 he received the DHEW Superior Service Honor Award.

Dr. Mead receives o certificate c<>mmemoroting her presentation of the Nii-I Lecture from Dr. Sherman. The anthropologist, here as on FIC Scholar, is also with Dr. Corl M. Leventhal, Acting Deputy Director for Science (second from left), and Dr. Eberhart. To illustrate ports of her talk she described dance customs of several countries.

Instead of battHng for territory on the ground, as mankind has done for a half million years, we are entering an era in which competition for air may become the focus of competition, Dr. Margaret Mead, re­nowned anthropologist, told an overflow NIH Lecture audience Oct. 17 in the Masur Auditorium.

1972 Birth, Fertility Rates Fall To Lowest Level Ever in U.S.

In 1972 birth and fertility rates fell to the lowest levels ever in the U.S. The birth rate was 15.6 per 1,000 population and the fer­tility rate was 73.4 births per 1,000 women in the child-bearing age, 15-44 yeaxs old.

The infant mortality rate also was down to 18.2 peir 1,000 live births, the lowest ever.

Dr. Mead, who has been asso­ciated for many years with the American Museum of Natural His­tory, New York, and is now a Fo­garty Scholar-in-Residence at NIH, said that shifting concepts of ter­ritoriality signal the start of a new period of social concern.

Individuals now must cooperate to reduce atmospheric pollution and assure orderly flow of air traffic, she said.

At her retirement party, Lydia Gates, printing specialist, admires one of her farewell gifts-a watch-presented by friends, NIH colleagues and co-worke rs. Mrs. Gates spent 28 years in Federol service, 1 S of them here in the Printing Unit, OAS. Her first boss, John W. Robinson, former director of Plonnin!.J, GPO, who retired 12 years 090, was o luncheon guest. Others included Jomes B. DoYis, OAS Director, and Donald R. Cushing, assistant director for General Services Management. She is flanked by her son William L. Gates (I), o pote nt attorney in private practice, and t;eorge C. Graham, chief, Printing and Repro­duction Branch.

Defense of territory, Dr. Mead pointed out, traditionally has been based on the fact that two people cannot occupy the same space at the same time. When the same space is desired by more than one person, conflict develops. The need to defend ,ground space has in­fluenced all aspects of living.

Dr. Mead showed motion pic­ture film to demonstrate manifes­tations of territoriality. One ex­ample, prepared by Alan Lomax of the Columbia University Chore­ometric projeot, depictt!d native dances from ·widely separated cul­tures.

In societies where space is a limiting factor, dancers often re­spond to rhythmic sounds while sitting or standing in the same place. In a culture dependent on hunting, native dances involve movements symbolic of searching.

In nations like Japan, where large numbers of people live and work together, ceremonial dances requiring coordination of many participants often are seen.

A sequence from a film by Dr. Richard Sorenson, NINDS, illus­trating children's exploratory be­havior limited by mothers in West­ei·n cultures was shown. This was contrasted with a film showing how Balinese children learn to walk by clin,ging to a centml rail.

"We use a play pen that teaches children that other pastures are greener," Dr. Mead commented.

To illustrate the changing sig-

Page 5

Dr. Sollner and Tas·aki Address NATO Institute

Drs. Karl Sollner and Ichiji Ta­saki recently spoke before the NATO Advanced Study Institute on Charged Gels and Membranes in Forges Les Earnc, France.

Dr. Sollner discussed The Early Developments of the Electrochem­istry of Polymer Membranes, an area in which he bas been active foi· 45 years.

Dr. Sollner, who now serves as an NIH consultant, retired last February after 26 years of Fed­eral service.

Prior to his retirement, he was chief of the Section on Electro­chemistry and Colloid Physics in the National Institute of Arthritis, Metabolism, and Digestive Dis­eases.

Dr. Tasaki, chief of the Labora­tory of Neurobiology, National In­stitute of Mental Health, discussed Fixed Charges in Excitable Mem­branes.

Dr. Donald Tower, NINOS Acting o;_ rector (I), presents a PHS Commendc­tion Medul to Dr. William T. London, senior veterinary officer in the Col­laborativ,e and Field Research, Infec­tious Diseases Branch. Dr. London rc­cei-,ed the award for his "contribu­tions to thi study of developmental pathology and nutrition in smoll prim­ates, and for pioneering the desig"' and development of isolotion facilities for monk'.:!ys which hove set the NIH standard."

nificancc of territoriality, Dr. Mead suggested that members of the audience would defend their seats if others tried to take them.

"But," she continued, "if the air were to become 1bad, a totally dif­ferent kind of defense would be required to make this room-or our world- a place worth living in."

Dr. John C. Eberhart, director of the Intramural Research Pro­gram, NIMH, was host for the lec­ture. Dr. John Sherman, Deputy Director of NIH, introdueed her.

Dr. Mead left, as she had ar­rived, attired in a floor-length red cape, an d carrying her famous forked walking stick.

Page 6

Cable TV Will Bring Medical Supervision To Elderly Patients

Two-\vay cable television is cur­rently being consideced as a way to improve health care delivery to the elderly.

The site of the project is the Gaylo,rd White House, a 248-apart­ment high-rise public building in East Harlem, New York. The me­dian age of the 339 tenants is 69 years.

The project is being coordinated by the National Library of Medi­cine, and funds have been awarded to the Mount Sinai School of Medi­cine to implement the program.

Tentative plans call for the in­stalla.ti-0n of cable television in each of the 248 apartments. A presently unused TV channel will be activ,ated for the exclusive use of Gaylord White residents and personnel at the medical center.

Project coordinators aim to in­volve the 1·esidents in many areas of program planning.

Body Signs Monitored T h e two-way communication

capability, in addition to allowing the t-enants to participate in dis­cussions and to ask and respond to questions posed over the channel, will also permit medical personnel at the Mount Sinai Medical Center to monitor and record the progress of patients while they remain in their apartments.

It will be possible, for example, for the Center to keep tabs on heartbeat, body temperature, blood pressure and other body signs us­ing special equipment developed by NASA for the astronauts.

Dr. Hilary Koprowski {I), director of the Wistor Institute, Philadelphia, and Dr. Donald Silberberg, of the Univer­sity of Pennsylvania Schaal of Medi­cine, answer questions following their announcement of a joint effort to de­termine the cause and course of mul­tiple sclerosis. The Hotiono I Institute of Neurological Diseases ond Stroke and the National Multiple Sclerosis Society ore providing $2.3 million over the next 3 yeari for the collob­a1<1tive study.

November 6, 1973

A Goy lard White House resident thoughtfully gazes from her window.

SUBTILIN ( Contltum! fro,n l'age 1)

tilin shows rather impressively, according to Dr. Gross, how rigor­ously structure has been maintain­ed throughout their evolutionary history. Both molecules have Jive rings of identical size and alpha­carbon atoms of the lanthionine residues possess D-configuration.

The structural elucidation posed problems because there was no methionine present for the usual nonenzynui.tic fragmentation tech­nique and subtilin resisted the at­tack of proteolytic enzymes under commonly used conditions.

Hew Methods Used To overc-0me these obstacles, the

NlOHD scientists used new tech­niques to split peptide bonds.

Thermolysin ,at 87°C cleaved the peptide 'bond between residues 19 and 20 and at 60°C the peptide bond 11-12. The latter permitted the difficult placement of the sul­fide bridges of lanthionine and two of the beta-methyllanthionine resi­dues.

As a result of these studies, Dr. Gross and Dr. Kosaku Noda ex­tended the chemistry of alpha, beta-unsaturated amino acids to peptide synthesis, and now link growing peptide chains via dehy­droalanine to solid supports. This new synthetic route facilitates re­moval of the peptide from the solid support and gives the amide directly.

Amides Studied

Many physiologically interesting peptides are amides, most promi­nent of these axe those amides necessary to release pituitary hor­mones.

When Dr. Bruce C. Nisula of this Branch tested the thyrotro­pin-releasing factor, synthesized via the new route, be found a full complement of biological activity.

While no peptide molecule re­sembling even portions of nisin or subtilin has been synthesized as yet, Dr. Gross and his young asso­ciates express confldence in the

DRG's Thomas Shepherd Gets Suggestion AW1C11rd

Thomas Shepherd, a computer programmer in the Data Process­ing Section, Statistics and Analy­sis Branch, DRG, received a Bene­ficial Suggestion Award last month.

Mr. Shepherd suggested a more economical method of producing and examing DRG IMP AC file in­formation by replacing the present IRS Query system with a micro­film tape system using 'Micro-Fiche viewers.

The Micro-Fiche system pro­duced actual operational savings in the amount of $14,700.

Mr. Shepherd is presented with a Ben­eficial Suggestion Award by Paul Burke <ri, chief of the Programming Unit, Data Processing Section, DRG.

eventual synthesis of nisin. First ,steps have already been

taken to provide synthetic frag­ments for the study of the rela­tionship between structure a n d function of the molecule.

A report of the structural elu­cidation of subtilin has appeared In the .fuly issue of Hoppe Seyler'8 ZeitselLrift fur Physiologiscke a1um1ie.

I enjoy convalescence. It is the part that makes the illness worth­while.-G-. B. Shaw.

THE NIH RECORD

Food C1ompositi,on Table Published by NIAMDD

The third in a series of world­regional food composition tables has been published by the National \ Institute of Arthritis, Metabolism, , and Digestive Diseases in cooper- , ation with the Center for Disease Control Nutrition Program and the Nutrition Division of the United Nations Food and Agricul­ture Organization.

The two-volume set, entitled Food Oonsumptfon 'l'able for Use in 1 East Asia and A Selected Bibli­ograpT.y on l!Jast A.sian Foods and Nutrition Olas1tifiea Accordfog to S.ibjcct Matter and Areas, is an essential tool for assessment of Asian dietary consumption and the nutritional status of the popula­tion in various countries of East Asia.

Supported by U.S.-Japan Coop­erative Medical Science Program funds, the current project follows the earlier publication of Food Composition Tables for Use in · Latin America (1961) and Africa (1968).

The East Asian food table pro­ject was initiated in 1970. In the course of the 8-year research pro­ject, study visits were made to Japan, Korea, Taiwan, Hong Kong, Philippines, South Vietnam, Laos, Thailand, Indonesia and Bm-ma to obtain the appropriate informa­tion.

The principal scientist on ihe project was Dr. W. T. Wu Leung of the CDC Nutrition Program (retired), who had also organized the earlier food tables for Latin America and Africa. She was aided by Dr. Benjamin T. Burton, asso­ciate director for Program, NIA­MDD, who served as coordinating project officer.

The most comprehensive, up-to­date Asian food composition table and bibliography yet published, the volumes a.re available from the sponsoring agencies, including NIAMDD.

Dr. I. Zipkin, Former NIDR Biochem.ist, Dies

Dr. Isadore Zipkin, a biochemist with the National Institute of Den­tal Research for 20 years until his retirement in 1968, died Oct. 17 at the Clinical Center. He would have been 59 on Oct. 80.

While with NlDR, Dr. Zipkin served as a scientist director in the Public Health Service Commis­sioned Corps. In 1968 he joined the faculty of the University of Oali• fornia at San Francisco as profes­sor of periodontology.

Dr. Zipkin was an authority on fluoride metabolism and authored numerous publications in the field of dental research. He is survived by his wife, Lillian, and two chil· dren-Richard a n d Michael-of San Francisco, and a brother, Philip, of Batavia, N.Y.

THE NIH RECORD

NIH Visiting Scientists Program Participants

10/9---J)r. Shigeru Nanno, Japan, Section on Molecular Structure. Sponsor: Dr. Erhard Gross, NIC­RD, Bg. 10, Rm. 5Bll.

10/10-Dr. Giorgio Racagni, It­aly, Laboratory of Preclinical Pharmacology. Sponsor: Dr. Er­minio Costa, NIMH, William A. White Bg., Rm. 101.

Others Noted 10/ 11-Dr Witold J. Rudowski,

Poland, Office of th e Director. Sponsor: Dr. Martin Cummings, NLM, Bg. 38, Rm. M142.

10/15---.Dr. Sitka Bose, India, Laboratory of Chemical Biology. Sponsor: Dr. Christian B. Anfin­sen, NIAMDD, Bg. 10, Rm. 9N300.

Israelis Visit

10/15-Dr. Avner Rotman, Isra­el, Laboratory of Chemistry. Spon­sor: Dr. John W. Daly, NIAMDD, Bg. 4, Rm. 210.

10/ 15-----Dr. Ben-Avi Weissman, Israel, Laboratory of Chemistry. Sponsor: Dr. David F. Johnson, N1AMDD, Bg. 4, Rm. 132.

10/16--Dr. Waldemar Wetekam, Germany, Laboratory of Biochem­istry. Sponsor: Dr. Robert F. Gold­berger, NCI, Bg. 37, Rm. 4E28.

10/17- Dr. Hillel S. Koren, Isra­el, Immunology Branch. Sponsor: Dr. William Terry, NCI, Bg. 10, Rm. 4B17.

The Ye rkes Primate Research Center in Atlanta recently held o 2-week in­ternational workshop on tronsplonta­tion genetics of primates. Dr. Michae l E. Keeling, chief veterinarian, draws blood from a young orangutan for im­munological studies. Eight teams of 50 researchers from The Netherlands, the United Kingdom, and the United States, including representotives from NCI, participated in the workshop. The Center is supported by the Divi •

' sion of Reseo rch Resources.

November 6, 1973 Page 7

Drs. Millard, Parakkal Join Grants Program

Drs. Sara A. Millard and Paul F. Parakka\ have joined the DRG Grants Associates Program for a year of training in grants admin­istration.

The Program trains scientists for administra,tive positions in ex­tramural 'research activities and is administered by the Division of Re­search Grants.

Dr. Millard comes t,o DRG from the Roche Institute of Molecular Biology where she bas been a vis­iting scientist in the institute's de­partment of bioohemistt-y since September 1972.

From 1964 to 1972, she was as­sociated with the University of Iowa, first as an assistant profes­sor in chemistry and psychiaitry, and later as an associate profes­sor in psychiatry.

Dr. Millard graduated with hon­ors from San Diego State College

Dr. Millord Dr. Parokkal

in 1960, receiving the B.A. degree in chemistry. She earned the Ph.D. degree in physical chemistry from Purdue University in 1964.

Dr. Millard's areas of research include neurobiochernistry, ribonu­cleotide reductase in the brain, and synthesis and metabolism of idole­alkylamines.

She is affiliated with several professional organizations and was secretary-treasurer of the Iowa Section of the Society for Experi­mental Biology and Medicine from 1971 to 1973.

Received Career Award

Dr. Millard was the recipient of a National Institute of Neurologi­cal Diseases and Stroke Research Career Development Award in 1972.

Before joining the Grants Asso­ciates Program, Dr. Parakkal was associated with the Oregon Regional Primate Research Center in Beaverton, first as a visiting scientist and later as associate scientist in th e departments of electron microscopy and reproduc­tive physiology. He was also asso­ciate professor of dermatology at the University of Oregon Medical School during 1969.

From 1962 to 1968, he held re­search positions with the depart­ment of dermatology at Boston University Medical School. He was a lecturer in biology at the Saared Heart Scholasticate, Bari­sal, East Pakistan, from 1954 to

Historica1 Nursi,ng Documents Donated to NLM

Dr. Abdellah (I), Dr. Kibrick, Mrs. Walsh, and Dr. Olch examine some manu­script items ond early publications of Flore nce Nightingale from the Library's collections.

Dr. Peter D. Olch, deputy chief, History of Medicine Division, Na­tional Library of Medicine, recent­ly met with nursing representa­tives to discuss the establishment of a national repository of manu­script materials related to the American nursing profession's de­velopment.

Dr. Anne K~brick and Margaret Walsh of the National League for Nursing donated a collection of papers, microfilm, and photographs to aid in documenting the early hist.ory of the American Society of Superintendents Training Schools for Nursing and the Na­tional Organization for Public Health Nursing.

Oommending th e League for their concern in preserving ma­terials for the use of scholars, Dr. Olch said, "I hope that their ac­tion will be an example for other organizations and individuals in­terested in preserving historically important nursing materials."

Dr. Kibrick, Mrs. Walsh, Dr. Olch, and Dr. Faye C. Abdellah, PHS chief nursing officer, will work together as an informal ad­visory group to identify other manuscript materials on the his­tory of American nursing for pos­sible inclusion in the NL:M collec­tion.

19M, and a demonstrator in zool­ogy at Fatima Mata College, Qui­lon, Kerala >St.a.te, India during 1953 and 1954.

Dr. Parakka\ received the B.S. degree in 1952 from Kera.la Uni­versity, Trivandrum, Kerala State, India; the ~LS. degree in 1959 from McGill University, Mont­real, P.Q., Canada, and the Ph.D. degree in 1962 from Brown Uni­versity.

Dr. Parakkial has attracted in­ternational attention for his re­search on the different aspects of keratinization and on the resorp­tion of collagen fibers.

New Code of Federal Regulations Affects All AEC-Licensed Agencies

The new Code of Federal Regu­lations affects all agencies licensed by AEC to use radiation sources and radioactive materials.

According to the guidelines re­cently issued by the Atomic Ener­gy Commission, employees should report possible radiation hazards that they observe.

Employees Report

At NIH, employees should in­itially report any condition which may lead to or cause a violation of AEC standards to the NIH Radiation Safety office, Ext. 65774.

The new regulations authorize employees to make written re­quests directly to AEC for an in­spection of the condition. Employ­ees may meet privately with the AEC inspector and may accom­pany him during the inspection.

Safe From Reprisals

Under the new code, individuals who report potential violations are protected from reprisal. Agencies are prohibited from discharging or discriminating against anyone who requests an investigation.

AEC safety standard violation notices along with agency replies must be available for review.

Personnel who work in radiation restricted areas, the new regula­tion states, must be informed of the use and st.orage of radioactive materials and radiation sources.

They must also be instructed a.bout health protection problems and procedures to minimize expo­sure. Individuals may have copies of their radiation exposure records such as film badge, bioassay, and whole body counting results.

Copies of the new code as well as the NIH Radiation Safety Guide and NIH AEC licenses are avail­able in the Radiation Safety Sec­tion, Bldg. 21, Room 116.

Page 8 November 6, 1973 THE Nill RECORD

Ger:onto'logical Society Stresses Ways Research lmpli'oves Lives of Aged

The contribution of research on aging for improving the lives of older people is the theme of this year's Gerontological Society meet­ing now being held in Miami Beach, Fla.

Thirty-three NIH-supported in­vestigators are presenting papers at the meeting attended by geron­tologists and allied professionals from the United States, Canada, France, Israel, Rumania, the U.S.S.R., and Venezuela.

A Presidential Symposium on contributions of gerontologica.l re­search opened the proceedings last night (Nov. 5) featuring Drs. Ai:­thur S. Flemming and Alfred H. Lawton as speakers.

Background Noted

Dr. Flemming is Commissioner on Aging, Administration on A,g­ing, HEW. He is a former Secre­tary of HEW and was Chairman of the 1971 White House Confer­ence on Aging.

Dr. Lawton, president of th e Gerontological Society, is on the staff o{ the Veterans Administra­tion Hospital, Tampa. He w a s fo1·merly Director of NICHD's Hu­man Development Study Center.

Dr. Leonard Hayflick, an NICHD grantee of Stanford University's Department of Medical Microbiol­ogy, will deliver the Rohen W. Klcemeier Memorial Lecture on Nov. 8 on The Strategy of Senes­cence.

In addition to special speakers, t he program includes scientific ses­sions, symposia, and round-table discussions in four sections of the Society's professional di visions: Biological Sciences; Clinical Medi­cine; Psychological and Social Sci­ences, and Social Sciences, and Social Research, Planning and Practice.

Some 300 papers are being pre­sented in these sessions during the 5-day meeting, Nov. 5-9. Of

$14.4 Million Awarded For Grants, Contracts To Study Sickle Cell

Grants and contracts totalling $14.4 million have been awarded by the National Heart and Lung Institute for research on sickle cell disease and for demonstration programs concerned with the dis­order's prevention, diagnosis, and t r eatment.

The awards, made through the National Sickle Cell Disease Pro­gram, provide funds for:

• Establishment of five new Comprehensive Sickle Gell Disease Centers and continued support of 10 similar centers established last year.

Organized around ongoing pro­grams in SCD, these centers com­bine research and demonstration projects.

• Establishment of 11 new Screening and Education Clinics for providing information, educa­tion, screening, counseling, and pa­tient referral services in urban, suburban, and rural communities.

Continuing support is provided for 15 previously established clin­ics.

• Four new targeted research projects on the improvement of laboratory diagnostic techniques in sickle cell disease and the treat­ment o{ sickle cell crises, includ­ing clinical evaluation o.r various anti-sickling agents.

An additional 24 projects initi­ated earlier, received continuing support.

• Forty-two regular research grants for basic and applied re­search into the nature and treat­menl of sickle cell disease.

SCD afflicts an estimated 50,000

these, 11 member s of NTCHD's Gerontology Research Center are presenting papers, and -four NIH staff members are serving as co­chairmen of various sessions.

Ross Holliday (1), Director of the OfficE of Engineering Services, pre sents 3 0-yeor certificates and pins to (I to , l: R. 0 . Brown, G. W . Cornwall, W . R. Schle­gel, C. H. Dove, W. C. McClure, H. L. Bynum, G. A . Taylor, H. V. Gill, a "d J. R. Robins.

Dr. Stone Gives Alumni Lecture; Gets Award From Alma Mater

Dr. Robert S. Stone, NIH Di­rector, returned to his alma mater -Downstate Medical Center of the State University of New York -on Tuesday, Oct. 30, to deliver the eleventh annual Alumni Night Lecture.

Dr. Stone, a graduate of the class of 1950, spoke on What We Have Always Wanted to Know and Haven't Been Afraid to Ask. His lecture traced scientific progress from ideas through breakthroughs.

At a reception and dinner be­fore his talk, Dr. Stone received th e Downstate Alumni Associa­tion's annual award for his achievements in medicine.

Americans, most of them blacks. These persons are subject to re­current sickle cell crises-painful, disaibling episodes that may be brought on by lowered oxygen ten­sion, infections, exposure to cold, dehydration, or other factors that cause large numbers of red blood cells to assume crescent or sickle shapes.

The sickled cells, unable to pass freely through smaller blood ves­sels, create a "log jam" effect that impedes bloodflow to the surround­ing tissues.

2 Million Carry Trait

An additional 2 million Ameri­cans are carriers of sickle cell trait. Carriers are healthy, but can transmit the genetic trait to their children.

If two can·iers o{ the trait mar­ry, the odds are one in four that a child born of this marriage will have $CD and two in foui- that the child \vill be a cai-rier .

ln response to a Presidential initiative, HEW increased the scope and tempo of its research and community sernce activities concerned with SCD in 1971.

A year later the National Sickle Cell Anemia Control Act estab­lished a national program of re­search, training, information, and community service directed against this disorder.

'l'he National Sickle Cell Disease Program is a cooperative endeavor involving NIH, the Health Services Administration, and other Federal, state, and private agencies.

Revised Publication Now Avail'able From DC'Rlf'

Recent modifications in the Di­vision of Computer Re.search and Te<:hnology's Report No. 9, ..4. Struc­fttrtl/1, Aasembl11 Lanquage Source Pro(Jr(tm Generator, have resulted in a revised printing of the docu­ment.

For copies of the new version, call the DORT Scientific and Tech­nical Information Office, Ext. 66203.

Ruth Dudley, NINOS Information Officer~ Honored by Her College

Mrs. Dudley, cited for her " ... dis­tinguished career as Public Informa­tion Officer of the NIH . .. " receiv .. d

her honorary degree of Doctor of Humane Letters from Or. Bonds.

Ruth Dudley, information officer, National Institute of Neurological Diseases and Stroke, recently re­ceived an honorary degree-Doctor of Humane Letters- from her alma mater, Baldwin-Wallace Col­lege, during the school's 128th An­nual Founders' Day.

In 1959, Mrs. Dudley had re­c.~ived that college's A l u m n i Merit Award. She clso had served as a trustee of the school from 1960 to 1966.

Honor Explained

Mrs. Dudley, who received her degree certificate from Dr. A. B. Bonds, Jr., College President, was honored for her " .. . abiding com­mitment to both the physical and moral well-being of man."

She was also cited for her work in the Refugee Relief Program for the U.S. Department of State, and for her services, with her late hus­band, as founder and director of the Rclig,jous Heritage of America.

Citotion Quoted

The citation pointed o u t that "Through this organization yo u encouraged a nationwide reawak­ening of interest in the deep inter­action of democratic freedom and religious conviction . . . "

It also mentioned Dudley Moun­tain in Antarctica ". . . named for you and your late husband ... as an enduring memorial of your work on a program for exploring this region ... "

Mrs. Dudley graduated from Bald­win-Wallace in 1939. She has been NINDS information officer since 1958-the first woman appointed I O of an Institute at NIH.

She is also probably the first information specialist at NIH to receive an honorary degree.

* U.S. GOVERNMENT PRINTING OFFICl!:1 1973- 544.902/s