U. 5. DEPARTMENT OF

H EALTH. EDUCATION. AND WELFARE

Dr. Eldon Eagles Named To Newly Created Post, NINOS Deputy Director

Dr. Eldon L . Eagles has been named deputy direetor of the Na­tional Institute of Neurological Dis­eases and Stroke.

In this new position, Dr. Eagles will share responsibility for the ln~tute's programs and activities with Dr. Edward F. MacNicbol, NINDS Director.

For the past 6 years D'l·. Eagles has se'l·ved as assistant director of NINDS. Since 1968 he has concur­rently served as acting associa'U! direc,tor for 0ollaborative and F ield Resem-ch for the Ins,titute.

Prior to joining NINDS, Dr. Eagles was associate research pl"O­fessor of Maternal and Child Health and the University of Pittsbul·gh Gr,-uiua.te Sch-001 of Public Health.

While at the Univeirsity, Dr. Eagles serves on various PHS re­search and training advisory com­mittees.

Dr. Eagles holds an M.D. and a Master of Surgery from Dalhousie University, Halifax, Nova Scotia, a Di,ploma in Public Health from the University of Toronto, and a Doc­torate in Public Health from The J ohns Hopkins Univers,ity.

He pi·acticed general medicine

Dr. Eagles' study of hea ring in ove r 5,000 Pittsburgh school children dur­ing the early sixties led to improved hearing tests.

foo· 3 years in a rui-al area of Can­ada and served a,s a medical health officer in Nova Scotia for 15 years.

He directed a child and maternal health program the1-e from 1954 to 1956.

ecor November 10, l 970 Vol. X.XII, No. 23

Dr. Frank (r) and some of his staff use II new computer system for determining which a spects of a monkey's response can be predicted from ncuroelectric signals recorded from the motor cortex. Laboratory membe rs (I to r) are: Paul Yarows ky, Kathleen Davis, Dr. R. Gilbert J ost , Dr. Donald R. Humphrey, and Dr. Edward Schmidt.

Ily Carolyn Holst ein

You stumble on a step and "instinc!Jh-ely" grab hold of the rail-­you've stopped yourself from falling without much eff<>rt. But imagine doing <the same thing with an artificial hand.

Although artificial hands can look fairly normal, they cannot as yet to unders.tand and therefore to perform very complex tasks O'!'

functions because they are not ui­rectly controlled by the body's nervous system.

To integrate them w:ith the nerv­ous system requires more under­standing of how the system works.

Th,is has commanded the atten­t ion of experts for years, for th':\ nervous system's oomplexity, which makes it so wonderful , ah;o makes it one of the mos,t difficult systems

A year later Dr. Eagles was a resoarch fellow at the Johns Hop­kins University School of Hygiene and Public Health and at the same time was Director of Studies for the Maryland State Planning Commis­sion Committee on :Medical Care.

During this J)e1·iod he conducted a study of medicaJ services and fa­oilitJies needed by handicapped chil­dren in Maryland which resulted in 10gislative action and the appro­priation of f unds.

Dr. Eagles, who has published s.ome 30 papers and monographs, is a fellow of several professional societies.

mimic. Being able to mimic the system

would not only enable scientists to develop better-more responsiv-.­ai·tificial limbs for amputees, but also help them to perfect sensory prostheses Ioi· blind and deaf per­sons, according to Dr. Karl Frank, chief of the NINDS Laboratory of Neural Control.

Such devices, already under de­velopment, may eventually help blind persons to navigate in their surroundings or decipher letters and even words.

These devices could work by pro­jecting tactile images onto the skb of blind pcTSons, producing a sensa­tion similar to that felt when some­one writes with bis finger on yonr back, or they might work by deliv­ering patterns of electrical stimuli directly to bhe brain.

Mimicking the system could also enable scientists to extend the capa­bilities of normally working limbs, by having information recorded from the brain bypass muscles and instead directly activate and control

(Ser NSRVOUS SYSTEM, Page 7)

NATIONAL INSTITUTES OF HEA LTH

Dr. Berliner to Receive Research Achievement Award of Heart Ass' n

Or. Robe1-t W. Berliner, NIH Deputy Di.root:or for Science, has been seleded to receive the Amer­ican Heart Association's 1970 Re­search Achievement Award.

The award is being pre.sented for his "many contributions to ca.rtlio­vascular research-particulllrly re­nal physiology- as investigator, as a teacher and trainer of young sci­erutists, and as an administrator."

Receives Award Thursday

Dr. Berliner will receive an hon­orarium of $1,000 and an illumi-· nated scroll at ceremonies opening tlhe Association's annual scientifi.c sessions this Thm-sday (Nov. 12) in Atlantic City.

Dr. W. Procto,r Harvey, AHA President, vnll pre.sent the award.

Dr. Berliner's interest in cardio­vascular phenomena wa;s evident early in his career by a. study show­ing that changes in human posture could res.ult in changes in blood cir­culation, producing a form of la.­bored breathing often associated with congestive heart failure.

In 1946, he reported a simple clinical procedure for measuring the rate at which blood flows through and is filtered by the kid­ney, and his investigations showed the effect of mercury preparations in increasing uhe secretion of urme.

Dr. Berliner made another major contribution in 1948 when he de­monstrated the secretion of potas­sium by the kidney.

He has done extensive srt;udies on

(See DR. "Bl::Rl,JNER. Pa.ye j)

TV Presentation on Viruses To Feature NIAID Story

"You and the Virus" may be seen on Channel 4 (WRC-TV) this Saturday, Nov. 14, at 1 :30 p.m.

The HEW-sponso1·ed televi­sion show will present the NIAlD st o1·y of virus.es and how they affect mankind.

Fealured ,vill l:>e Drs. Daniel Mullally, Wallace Rowe, Sam­uel Baron, and Julius Kasel; also, Edward Harvey, Marga­ret Huber, and Holly Smith.

Page 2 November 10, 1970 THE NIH RECORD

Published biweekly at Bethesda, Md., by the Publicat ions and Reports Branch, Office of Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­gators in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on request. The NIH Record reserves the right to make corrections, changes or dele­tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare. NIH R9'ord Offi,o .... ................... , Bldg, 31, Rm, 28-03, Phone: 49-62125 Editor ... .................................................. ...... .. ..... ...... ......... Frances W. Davis

Stoff Correspondents ADA, Nelson S.parks; BHME/ OD, Florence Foelak; CC, Elsie Fahren­thold; DAHM, Laura Mae Kress; DBS, Faye Peterson; DCRT, Joan Chase; DDH, Carolyn Niblett; DGC, J ames McLaughlin; DMI, Florence Foelak; DN, Evelyn Lazzari; DPHPE, Eleanor Wesolowski; DRG, Marian Oakleaf; DRR, Dave Dunlap; DRS, Robert Knickerbocker; FIC, Jan Logan; N CI, Pat Gorman; NEI, Julian Morris; NHLI, Bill Sanders; NIAID, Krin Larson; NIAMD, Katie Broberg; NICHD, Lloyd Blevins; NIDR, Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS, Wanda Ward­dell; NIMH, Daniel Rice; NINDS, Anne Tisiker; NLM, Peter Monk.

Employees May Consult Counselors on Enrollment In Federal City College

'I'wo counselors from Washing­ton's Federal City College will be at NIH Nov. 17 and 18 to advise em­ployees about educational oppor­tunities at the college.

The counselors, Carol Spencer and Yvonne Coursey, will be avail­able for half-hour appo~ntments in Bldg. 31, and if there are sufficient requests, appointments may also be scheduled Nov. 19 and 20.

An appointment may be made by calling Training a.nd Employee Development, Ext. 62146.

Students may enroll in the Fed­eral City College for bachelor or graduate degrees or <in the non­degree progziaro. Both day a.nd eve­ning courses are given.

The basic requirement for enroll­ment is a high school diiploma or the equivalent.

The e-0llege is the first Urban Land Grant institution in the coun­try. Because it receives Federal funds, its tuition charges are low.

Tuition oosts are $25 per full­time qua.r>ter for D.C. residents and $240 for non-oresidents. Part-time tuition cost is determined by the number of credit hou:rs.

NIH Television, Radio Program Schedule

Television NIH REPORTS

WRC, Channel 4 1 a.m. Wednesday

November 11 Dr. Frank W. Hastings, chief,

Artificial Heart Program, NHL!

Subject: Artifioial Hearl Pro­gram, Pa.rt 2 (R)

November 18 Part 3 of the above program

(R) Radio

DISCUSSION: NIH WGMS, AM-570-FM Stereo 103.5-Friday, about 9:15 p.m.

November 13 Dr. Henry M. Fales, NHL! and

Alan Demmerle, DCRT Subject: Automation in the

NIH Laboratory

November 20 Dr. Carl Kupfer, Direot1•!", NEJ Subject: The Role of NEI in

Combating Vision Disorders Interview takes place during in­

termission of the Library of Con­gress concerts.

NIH Ski Club Plans Holiday Trips to Several Areas The NI H Ski Club will start

its winter season early this year with a 4-day Skifest in the Lauren­tian Mountain Resort of Sun Val­ley, Province of Quebec, from Nov. 25 to Nov. 28.

Members are also participating in a 2-weck ski holiday to Kitzbuhel in Innsbruck, Austria over the Christmas holidays.

Other trips are being planned for New England and the deep powder

area of the Rocky Mountains. Seve.ra.l weekend trips will be sche­duled for Blue Knob and Seven Springs areas in Pennsylvania, too.

A meeting will be held at noon, Nov. 18, in Wilson Hall (Bldg. 1) to discuss these events. Also featured will be a ski fashion show and equipment demonstration.

Anyone interested in the club activities may contaot the R& W Association Office, Ext. 66061.

Blood Bank at CC Initiates New System; No Changes in Benefits to Employees

The Clinical Center Blood Bank is now operating the NIH blood donor program-with its blood credit system--on an independent basis.

The new progran1 became effective on Oct. 15. Under the old system, the Blood Bank had a contract with the

American Red Cross, ·and blood do­nated at the Clinical ,Center was credited to the Washington Region­al Red Cross Blood Program. Now it is credited to NIH employees.

Nothing changes as far as bene­fits to employees are concerned. Donors can still give blood at the CC Blood Bank and earn blood cov­erage for all employees and their families.

Alternate Pion Continues

The alternate free pint which is donated is needed to earn this cov­er-age. Donors oontinue to be paid for every other pint.

Employees may have 4 houn; ad­ministrative leave-at the discre­tion o.f the supervisor-at the time of donatiing. All dooations are re­oorded, on an NIH card now instead of a Red Cross ca.rd.

"The new blood credit system is really much more efficient,'' Dr. Thomas C. Chalmers, OC Di.rector, explained, "since we can respond to all the blood needs of employees di­rectly instead of through a middle­man."

Schmidts Donate One of the last NIH employees to

give under the old Red Cross sys­tem was Dr. Paul Schmidt, Blood Bank chief; one of the first dono:r6 under the new NIH system was his wife.

Both are Rh negative, but Mrs. Schmidt says, "I have given more blood than he has, and mine is bet­ter."

Both of them sbarted donating at the age of 18. Dr. Schmidt admits, "This was a few years ago."

He remembers the dalte of his

Film Encourages Employees To Plan Secure Retirement

A film on retirement entitled, "The Root of Your Life," is be­ing presented next week by the Employee Health Service.

The 28-minube color movie tells the story of how retire­ment plans were introduced to industrial workers and their amusing reactions.

The film is being shown to encourage employees to begin planning now for the time when they can terminate their careers and enjoy life with a feeling of security.

The EHS movie will be shown at the Jack Masur Audi­torium, CC, on Wednesday, Nov. 18, at 11:30 a .m. and 12:15 p.m.; at Conference Room A, Westwood Building, Thursday, Nov. 19, at 1:15 and 2 p.m.

When o fellow needs o blood tronsfu . sion, your donation moy be the one that con pull him through the crisis.

first vis-it to a Red Gross Blood Cen­ter because it was the day he was acc~pted by the U.S. Army.

He also admits that he is proud of Mrs. Schmidt, who has supplied many O Rh negative pints of blood for NIH patients in emergencies.

The CC Blood Bank has developed many techniques and establis!hed it­self as a leader in modern blood­banking.

Components Serve Needs For example, by using blood com­

ponents (splitting fresh blood into many parts) one pint provides ther­apy for several patients. Each com­ponent serves a specific need for ea.ch patient, and no potibion is wa.sted.

Installation of a pioneer comput­er system has proved to be a step forward also. This Donor File and Recall system has enabled the Blood Bank staff to record and quickly retrieve valuable informa­tion about individual donors.

Comme rcial Sources Eliminated Elimin,ation of the commercial

blood bank source for NIH supplies is another imporlant recent im­provement. The result of this ac­tion, which was based on research conducted by the Blood Bank staff, has been a greatly decreased inei­dence of transfusion-xelated hepa­titis in the Clinical Center.

A ca.JI to the CC Blood Bank, Ext. 64509, will give:

• :More in.formation about the new blood credit system,

• The Red Cross Blood Center schedule for those who wish -to keep a personal affiliatlion with the o,r­gll.ni,1abion 's program,

• An appointment to deposit blood in the OC Blood Bank.

1

1 ( (

1, u l

s I g V

p

a t :i: t t t

t g I t r.

i: g D s 3

t C s e

s

I t t

THE NIH RECORD

Three Training Programs Offer Eligible Candidates Chance to Aid Careers

NIH is seeking candidates for long-term traiTili1g opportunities under the Career Education Awards, the Systematic Ana.lysis, and the Mid-Career Programs by Nov. 16.

The first two programs are spon­sored by the National Institute of Public Affairs; the Mid-Career Pro­gram, sponsored by Princeton Uni­versity.

Plans Assist Executives

All three plans assist Federal and stiate executives in developing those employees identified as com­petent to assume high-level posi­tions and provide specific edU(:ation that agencies are usually not able to offer.

Eight universities participate in the Career Education A wards Pro­gram: Cornell, Harvard, I ndiana, Princeton, Stanford, and Universi­ties of Southern California, Virgi­nia, and Washington.

Six major universities take part in the Systematic Analysis Pro­gram: Universibies of California, Maryland, and Michigan, Massachu­setts Im,-titute of Technology, Harv­ard, and Stanford.

Assignment of selected nominees to universities is the responsibility of the U.S. Civil Service Commis­sion; howevro.·, when possible, pref­erences will be followed.

Select Own Program

Each participant is allowed to select a study program tailored to his specific needs. He will be able to attend special seminars and par­ticipate in other educational activ­ihies.

The eligibility requirements for the three programs vary. Generally, applicants should have been Nl H employees for at least 2 yoors, and have an undergraduate achievement of at least a "B" ave.rage.

The eligibility grade varies. For the Career Educa,tion Awards, GS 11 through GS 15 or equivalent ; for the Educational Program in Systems Analysis, GS 9 througih GS 13 or equivaJent. Applicants for the Mid-Career Program at Prince­ton should be in grade GS 14 or above.

Age Requirements Give n

Ge=al age requirements are: between 28 and 35 years for the Career Education Awards Pro­gram; between 25 and 30 years for the Systematic Analysis Proi,'Tam, and in the thirties or forties for the Mid-Career Pro.gram.

Applications must be received by the Office of the Assistant Dfrector for '!'raining and Employee Devel­opment, Office of PerS-Onnel Man­agement, no later than Nov. 16.

Further details may be obta:ined from the Training Office.

November 10, 1970 Page 3

Progress Report of CFC Shows NIH Has Reached 87.6 Percent of Goal

Drs. Hartley, Huebner Share 1970 Kimble Award

Three more groups have exceeded their Combined Federal Campaign quotas b1·inging NIH to 87.6 per­cent of i~ goal.

Their percentages are: BHME, 119.5; NLM, 107.5, and the Fogarty International Center, 128.7.

The Oct. 28 progress report shows total NIH contributions of $191,485.81 with 77.1 percent par­tieipatfon.

'l\vo organizations, BHME and NIGMS, have re.adhed t heir goals with 100 percent or more participe­tion.

"We are deeply groteful to all who have responded so generously thus far in the campaign," said Dr. Carl G. Bake•r, Director of NCI and CFC Chairman.

After ,the official close of the cam­paign, contributors may send dona­tions directly to the Combined Fed­eral Campaign Headquarters, Nas­sif Building, Room 3411, 400 7th Street, S.W., Wru,hington, D.C. 20546.

CC Patients'

Two cancer research scientists from NIH-Dr. Janet W. Hartley and Dr. Robert J . Huebner-shared the 1970 Kimble Methodology Award.

The co-winners were ci-ted for their work in significantly advanc­ing methodolgy and knowledge in virology and oncology.

Dr. Hartley is in the Labo1-artory of Viral Diseases, Naliional Insti­tute of Allergy and Infectious Dis­eases; Dr. Huebner is chief of the Viral Carcinogenesis Branch, Na­tional Cancer Institute.

The Kimble Awa.rd, a $1,000 cash prize and engraved plaque, is made annually by the Conference of Pub­lic Health Laboratory Directors of the American Public Health Associ­ation.

The award, sponsored by Owens­lllinois, Inc. was presented at the annual APHA meeting Oct. 26 in Houston, Tex.

Methods developed by Dr. Hart­ley have improved studies of human and animal viruses and provided tools for the detection and charac-

Winne rs in the CC Patients' Annual Hobby and Occupational Therapy Shaw received Achieveme nt Trophies for the items judged best. Some 65 patients displayed their arts a nd crofts, made during their stay here, in the CC lobby: Theresa Gorton (top left), St Louis, Mo., won first place in "The Most Original" category with a dry flowe r arrangement; Frances J. Habiak (top right), Sayer­ville, H.J . received an award tar he r knitted poncha in the "Most Likely to Be Purchased" category. Leonard E. Spires, Riverside, Calif., wan "Best in Show" for his fra med appliquc of golden eagles.

Or. Huebner (I) and Or. Hartley discuss virus research for which they received the 1970 Kimble Methodology Award .

teriz.ation of the naturally-occur ­ring C type leukemia viruses in mice.

This latter work has led to new corn:epts and methodological ap­proaches to the study of human cancer.

Some of Dr. Hartley's vfrus test systems now in use include adeno­vi:ruses, cytomegaloviruses, mouse polyoma viruses, and mouse hepa­t itis viruses.

She als,o developed a method for standardization of the oomplcment fixation test for murine leukemia viruses and in vilffo isolation, a s­say, and rescue systems th.alt are now being adapted to study human cancer.

Wark De scribed

Dr. Huebner's work has centered on the detection of antigen associ­ated ,vith tumors produced by viral agents.

With his associates he has de­monstrated the occurrence of virus­specifie, complement-fixing antigens in tumors induced by the adeno­viruses, Rous sarcoma vb:us, SV-40, and animal leukemia viTuses.

One practical application of his findings would permit a searoh for viral "fingerprints" in human tis­sues and thus help to answer the question of th.e causal role and identnty of viruses in human cancer.

Dr. Davies Directs Lab Under Rotating System

Dr. David R. Davies has been ap­pointed acting chief of the Labora­toL·y of Molecular Biology, National Institute of Arthritis and Metabolic Diseases.

He will serve for one y,ear, re­placing Dr . Gary Felsenfeld, who headed the laboratory from Novem­ber 1969.

A system of rotating th.e position of chief of the laboratory is now in its second yea.i-. It is believed to be tJhe first such system to be used at NIH.

L. Lee Monue l hos bee n oppointed Executive Office r of the Division of Computer Research and Technology, which he joined in 1966. For 5 years, he was Administrotive Officer far the NCI intramura l programs.

3 Members Named to Nat'I Advisory Council On Health Professions

Three members have accepted ap­p ointment to bhe National Advisory Council on Health P1'ofessions Edu­cational Assistance: Drs. :Maurice J. Hickey, Mabelle G. McCullou gh, and David W. Talmage.

Dr. Hickey has been Dean of the School of Dentistry, University of Washington, sance 1956. From 1948 to 1956 he served as Associate Dean of the Faculty of Medicine and Execut ive Officer, De.partrnent of Denm.stry, Columbia University.

Dr. McCullough is Assistant Dean of Students, University of Milrne­sota, and has been associated with the University since 1945.

She has served as a member of tlhe Minnesota Governor's Commis­sion on the Status of Women, and has produced two television pro­grams on public school financing.

In addition to being Dean '.lf the School of Medicine, University of Colorado, Dr. Talmage has been professor of Medicine, profe,;sor of Mic:robiology, and chairman of the latteJr department.

November 10, 1970

Researcher Finds That Sudden Deafness May Be Indicator of Systemic Disease

Sudden deafness can b<' an indicator of various systemic diseases, a researcher at the University of Michigan ha~ found. While other scientists have suspected this, many researchers considered sudden deafness to Ix, u. problem of the inner eair or C>f the temporal bone, rthe bone a,t the base and sides of the skull rthat contains the organs of hearing.

In a study of 40 patie11ts with sudden deafness, the investigator found that 22 had a systemic dis­order that could affect hearing.

Dr. Burton F. ,Jaffe conducted the study over a 5-year period at the University of Mich~gan Medical Center in Ann A1·bor. It was sup­ported in part by the National In­stitute of Neurologic.al Diseases and Stroke.

The patients included one man w~th fat emboli, clot,s which travel through the bloodstream. When these clots reach a very small blood vessel they get stuck and block the vessel.

Eleven of the sudden deafness patients had hypercoagulation, aJ1

accelerated ra.te of blood clotting which can produce a thrombosis or clot somewhere in the blood vessels. And another 10 patients ha<l upper respil"atory infections that could have affected their hearing.

Specia list Ale rts Internist

Dr. Jaffe pointed out that his findings a.re evidence that physi­cians should begin to think of the ear much as they do the eye--as a sensitive indic.atoT of blood vessel pathology or other systemic dis­ease.

He added that the otorhinolaryn­g,ologist, the physician who special­izes in ear, nose, and throat prob­lems, c.an be bhe key specialist to alert the il'lJternisrt; to serious sys­temic dhorders.

When Dr. Jaffe began his study, he kept in mind the previously stated theory that sudden deafness could result from the sudden clos­ing off (occlusion) of a blood ves­sel.

1fost of his patients <lid not have evidence of vasculro: diseases such as diabetes, hardening of the arte­ries or hig,h blood pressu1·e.

Blood tests ,showed tha:t 11 pa­hlents did have hype1,coa.gulation and three patients had ,cha.nges in vision which occurred sud-denly, in­dicaiting vascular problems.

Another patient with sudden deafness died, and examination of the inner ears showed evidence of plugs in the blood vessels.

Although the precise relationship between plugs in the blood vessels and sudden deafness is not yet known, these findings alerted phy,si­cians to the possibility that the pa~ tients had ,a blood dot somewhere in their system.

The single patient with sudden deafness due to fat emboli was a medical student who had been in a moto1·cycle ae0ident. The deafness developed 5 days after the a.ccident and followed other symptoms of fat emboli including confusion, 1-espira­tory problems, a rash, and vision pmblems. Medi.cal therapy cleared up the fat emboli and his heari11g problems s lowly disappeared.

Infections Prominent

In 10 of the other patients wit h sudden deafness, Dr. Jaffe found a fourfold or greater rise in blood antibodies indicating a recent in­fection-in six cases to mycoplaiSma pneumo•niae, in three cases to adenovirus, and in one to para.in­flue,nza.

In looking back over the medical literature, he found that one out of every three pauients with sudden deafnoss had had a recent mild up­per respira,tory infection.

In most of these infections, the virus gets into the blood stream and damage to the inner ear may be a local manifestation of thls infee­tion.

Further study showed that one­third C>f the 40 patients had some damage to both ears during the ep,i­sode of sudden deafness. Dr. Jaffe noted that dama.ge to both ears is further ewdernce 1,hat a systemic disease is rnvolved.

THE NIH RECORD

Dr. Walker Is Appointed Deputy Chief, Baltimore Cancer Research Center

Dr. Michael D. Walker was re­cently named deput y chief of the National Cancer Institute's Balti­more Cancer Resewch Centei-.

He will also mtain his posation as head of the Section of Neurological Surgery at the Baltimore facility.

Dr. Jerome B. Block, ehief of the BCRC and a,;sociate direclor of the Clinical Oenter, commended Dr. Walker's outstanding achievemen,ts in the clinical investlig1a.tion of brain cancer and other malignancies of the central nervous system.

In his new posit,ion, D1·. Walker will play a prominent role in the overall management of prog1:am efforts.

Serve s at Lahey Clinic

A graduate of Yale Univemity and Roston University School of Medi0ine, he served as a Fellow in Neurosurgery at the La.hey Clinic in Boston.

Before joining NIH in 1965, he was clinical instructor in Neui-o-

Dr. Walker developed and choired the Brain Tumor Study Group.

surgery at Harvard l.'niversity Medical School.

Dr. Walker began his Federal career as a medical officer in NCI's Li1boratory of Chemical Pha1·ma­cology.

His primary research interests in­v:ilve the development of laboratory anima.J models of brain tumors and the pharmacology of anticancer drugs with respc-ct to normal brain and cerebrospinaJ fluid and bi-ain tumors.

Yerkes Center Research Described in New Atlas

Otis Ducke r (center left), c hief, Supply Ope rations Section, SMB, presents cash for Superior Pe rformance Award to Walte r Chakwin, Mate rie l Storoge Unit h ead, ond unit employees. The grou p displayed outstanding dedicotion in m cv­ing the SMB Central Storeroom from the NIH rese rvation to the Danae Building in Rockville without inte rruption to service. Haywood L. Turner who contributed much to the success of the move, was not present far the picture .

A reeently published book, The Atlas of Comparative Primate Hematology, by Dr. Hans-Jurg Huser, i.s based on work he did as a visim.ng scientist durmg 1966-67 at the Yerkes Regional Primate Research Center in Atlanta, Ga.

The cente1.' is supported by the Division of Research Resources.

The referen.ce w'Ork oompa.r"-5 t,he blood and bone ma.11:ow of non­human primates. It includes materi-

al rarely found in conventional ref­erences on hematology, such as elec­tron microscopy and histochemistry of leukocytes.

The book is the first on hematol­ogy to use computer methods for evaluation of nrn·mal values, a method described by Dr. Geoffrey Bourne, Director of the Yerkes Center, as vastly superior to the cons,tant model used thus far.

THE NIH RECORD

3 Executives Appointed To Top-Level NCI Posts

Three executive app()intments in the National Cancer Institute have been annour,ced: Dr. Frank J. Rau­scher, Jr. becomes scientific director for Etiology; Louis M. Ca.rrese, associate director for Progre.m Plan­ning and Analysis, and Calvin B. Bald­win, Jr., executive off-icer.

Dr. Raus~her, an autho-rity in the field of viral oncol­ogy, was formerly acting scientific di- Dr. Rauscher rector for Etiology (see The NIH Record, Nov. 26, 1969).

He is noted for his quantitative studies on host factor.s in oncoge,ne­si.s associated with tumor viruses, including a murine leukemia virus whiclh he disoovcrcd.

Co- Deve lops Plannin9 Method

Mr. Can-ese joQne<l NCI in 1962. As program planning officer and late,r deputy associate director fol' Program, he developed methods for research planning, analysis, and co­ordination.

He is co-<leve.Ioper of the Con­vergence Technique-,an innovative planning method uniquely suited to research planning-which has been used in the formulabion of plans fo1· major cancer research programs and by several medical organiza­tions.

Mr. Carrese Mr. Baldwin

Mr. Carrese received his bache­lors and masters def/,'rees from the Unive1·sity of Rochester, and has completed ihe courses for his Ph.D. in Industrial Sociology at the Uni­versity of Maryland.

Mr. Baldwin is a Phi Beta Kappa graduate of the University of North Carolina. He rece·ived his M.A. de­gree in Public Administration from Harvard University.

Joins N IH in 1953

Since his first NIH appointment as management analyst, Office of the Director, in 1963, he has se.TVed in administrative posi,bions with the Division of General Medical Sci­ences and the Division of Research Grants.

Mr. Baldwin's most recent posit was as executive officer of the Na­tional Institute of Child Health and Human Development.

November 10, ] 970

2 Studies Seek to Pinpoint Mechanism By Which Bacteria Destroy Gum Tissue

Two studies to pinpoint the mechanism by whdch bacteria living in the mouth destroy tooth-supporting tissues in periodontal disease (pyorrhea) are under way ait the Forsyth Dental Center in Boston. Periodontal disease is the chief ea.use of tooth loss in adults.

The National Irwtitute of Dental Research 1~s awa1'ded grants to Ors. James T. Irving and Philias R. Garant for the first year of their studies. The vesearchers hope to discover t he cause of this wide­spread disease so tha.t it can 1:,e prevented.

Periodontal disease begins insidi­ously. 'l'he gums become red and inflamed and pull away from the teeth. Pocke<t.s form near the gum line. 'rhen the gums ulcerate and bleed, pockefa dcepe,n, and inflam­mation sp,reads.

At the same time, the bone un­derlying the gums is eaten away or rnsorbed by bone-destroying cells. Because the teeth are normally held firm by this alveolru· bone, its de­skuction leaves the teeth so wob­bly that in time they fall out.

These symptoms-including the s.cve1·e bone loss-can be induced in rats that are raised in a germ-free environment by infecting them with bacteria from human periodon­tal pockets. Otherwise, the germ­free animals show only very s low bone deterioration with age.

Tissues Compared

By comparing tissues in rats reared free of germs throughout the·ir lives with their litt.el' mates infected later with known germs, the researchers hope to pick out the disease-ca.using organisms and pinpoint the mechanisms by which they de.'ltroy the toobh"\Supporting tissues .

Although formation of a bacterial mat (dental plaque) o.n teeth around and under11eath the gum line is believed a cause of the con­dition, exactly how this ma.t tl'ig­gers bone destruction r emains a mystery.

According to earlier work by Dr. Irving and others, bone-destroying cells are attracted to bone aftel' its organic framework undergoes cer­tain chemical changes.

Dr. Irving hopes to detel'mine whcbher bacterial factors are re­sponsible for those bone changes and whethe1· bacteria work havoc on the bone by first causing inflam­mation.

This procoss is believed to be involved because inflamed tissue is always present near the resorbing alveolar bone.

To determine whether bacteria are essential to bone loss, the sci­entists will compare ~veral types of rat bone after each has been ex­posed to inflammation caused by pure cultures of bacteria from periodontal pockets, or by certain bacterial pa:rt.s or products, or by such sterile inflammatory agents as •turpentine.

Dr. Garant will use the eledron microscope to study the u ltra­structural evtmts taking plaee with­in booth~supporting tissues of the same expel'imental animals. The knowledge gained through the cel­lular a nd subcellular events occur­ring •in t he experimental animals will be used t o find the mechanisms I'esponsible for tissue damage.

Dr. Garant will al;;o study lymph nodes of the head as well as the spleen to see how the microbes af­fect; the body's immune system.

New Studies Mode Possible

To distinguish tissue damage caused b y the bacteria themselves from that caused by the body's im­mune response to them, the scien­tists will give some of the rats drug's lihat dampen the immune re­sponse before infec.ting them with the microbes from human pe1·iodon­tal pocket.s.

By using germ-free rats exposed to known organisms only, the For­syth scientist.<, can study many as­pects of periodont al disease that cannot be studied in humans.

Should their discoveries lead to new ways to prevent periodontal disease, they will benefit the three­of-every-four adults in this country who have some form of either gin­givitis (gum inflammation) or periodontal disease.

DR. BERLINER (Contin1tcd front Pcigc 1)

the chemical treatment of human malaria, on the renal regulation 0f acid-base balance, on the me,!ha­nisms by which urine is concen­trated and diluted, on tJhe C<'llular exchanges among potassium, sodi­um and hydrogen, and on the trans-· port of biologically important mole­cules across cellulru· membranes.

R e has contributed to textbooks on medicine and physiology and has published more than 100 pape1·s.

Serves on Many Journols

Dr. Berliner has served on the editorial board of the Heart Asso­ciation's monthly journal, Circula­lion Research, foi- more than a decade.

He has also been on the editorial boards of AHA's Circulation, and the American Journal of Physiolo­.c;y, and Journal of Clinicr1l Jnvesti­gcition.

A member of the National Acad­emy of Scie,nce,s since 1968, Dr. Berliner received Modern Medi­cine's Distinguished Achievement Award in 1969; the Bicentennial Medal of Columbia University's College of Physicians and Surgeons in 1967, and its Alumni Award in

Page 5

Dr. Huber Joins NINOS; New Associate Director Served on Nat'I Council

Dr. \Nar1·en V. Huber, formerly chief of Neurology of the Veterans Administration, has been named associa;te director for Collaborative and Field Research, National Insti­tute of Neurological Diseases and Stroke.

While coordinating the V A's na­tionw ide neurology program during the past 10 yea.rs, Dr. Huber worked closely with NIH and se:rved on the NINDS National Advisory Council.

Dr. Huber will be responsible for 3 major ai,e,as: collab01·ative peri­natal research, correlruting factors in pregnancy and early life causing cereb1,al palsy, mental retardation, and o\lhe1· neurological and sensory disorders; epidemiological research, investigating the role of so,cial, geo­graphic, and genetic factors in neu­rological diseases, and special pro­jects, including collaborative stu­dies on epilepsy and head injury.

Wartime Se rvice Noted

Dr. Huber completed his premed­ical training at Columb<ia Univer­sity, and received his M.D. from Long I sland College of Medicine in 1933.

During World War 11 he served as chief of Neurology and Psychia­try in U.S. Army hospitals in Ire-

Or. Huber will supe rvise N INOS con­tracts ond 9ronts allocated to fie ld ond collaborative research.

land, England, and France. Dr. Hu­ber later served as chief of Neurol­ogy at Brooke Army Hospital, San Antonio, Tex. from 1950 to 1953.

From 1953 to 1958 he was chief of Neurology in VA ho&pitals in Richmond and Denver. In 1968 Dr. Huber served as Director of Re­search for t he Lynchburg Training School and Hospital Colony, Vir­g·inia, and then returned to the VA h ospital in Denver until he came to the VA National Office in Washing­ton in 1960.

1966. He also rnceived the Homer W.

Smith Award in Renal Physiology in 1965, and the HEW Distin­guished Service Award in 1962.

Page 6 November 10, 1970

Death or Damage From lead Poisoning Reduced by Early Testing and Treatment

Increased testing for lead poisoning in children has caused a drastic reduction in deaths and brain damage from this environmental hazard ove1· the past 5 years, according to an NIH-supp.oi:ted investigator at the Johns Hopkins University School of Medicine. than 5 percent.

Dr. J. Julian Chisolm, a research Following treatment with BAL scientist as well as associate chief and EDT A, whkh requires hospital­of pediatrics at Baltimore, Md., ization in the center, the child is City Hospitals, believes greater treated with another, investigation­awareness of danger and early al, drug, d-penicillamine. Penicil­treatment along with the increased !amine removes the lead from the testing bring about the reduced tissues where it is stored. death rate. Penici!lamine treatment is con-

Lead poisoning is far from being tinued for long periods, sometimes wiped out though, said Dr. OhJsolm, years, to remove all the lead. who ha~ just completed a one-year "If we had good screening and study in the Johns Hopkins clinical early detection, we could cut the research center for children, sup- time of pen:icillamine treaitment ported by the Division of Research drastically," Dr. Chisolm said, Resources. adding:

Seeks Early Detection

The study was aimed at finding an easy method of detecting the dis­ease in its early stages. The longer a child goes undiagnosed, he noted, the more likely he is to have brain damage.

Almost half the chi ldren who re­cover from acute lead poisoning have brain damage, which causes convulsions, irritability, and subtle learning defects.

Fot· children who have a recur­rence of severe lead poisoning, the 1·ate o( brain damage is virtually 100 percent.

Lead poisoning strikes mainly among children who live in dilapi­dated urban housing and contract the disease by eating leaded paint flaking from walls and interior sut·­faoes.

Although the true incidence of this disease is not known, surveys have shown that as many as 5 per­cent of the children in these so­called "lead belts" may have lead poisoning.

In his study, Dr. Chisolm found that the only completely reliable method of detecting lead poisoning is a blood test. However, this re­quires a sample from a vein, a difli­cult procedure in small children.

Refining Procedure

Dr. Chisolm is now trying to re­fine this procedure, and hopes to reduce the amount necessary to a few drops obtained from pricking a finger.

He believes this ''micro test" will furnish an effective method of screening for lead poisoning among high risk populations to detect the disease before any symptoms are present.

"If the child continues to ingest lead, the drugs don't do any good, and he has to be hospitalized and we have to start all over again."

Dr. Warren G. Stamp Appointed To Advisory Council of NIGMS

Dr. Warren G. Stamp has been appointed to the National Advisory General Medical Seiences Council. His term will nm through Septem­ber 1974.

Dr. Stamp is chairman of the De, partment of Orthopedic Surgery at the Univen·sity of Virginia Hospital in Charlottesville, Va.

l /

Fed'I Professional Ass'n Goals Noted by Speakers At Information Meeting

"Professional employees nend a mechanism for bringing their views and desires to bear on the legisla­tion and regulations that affect bheir work and environment," Dr. Allen V. Asitin told NIH employees who attended the Federal Profes­sional Association information meeting held at Wilson Hall on Oct. 21.

Dr. Astin, former Director of the National Bureau of Standards, was instrumental in starting the large FP A chapter there.

Several past presidents of other FP A chapters spoke, tracing the organization's past histm·y and dis­cussing its present goals.

Improveme nts Suggested

These include establishment of a separate classifica,tion system for profess.ional and executive em­ployees, improvement of their edu­cational opportunities, and more effective use of available adminis­trative authority to vary the duty hours of such employees.

Dr. Edwin D. Becker, NlAMD, who was <>hairman. of the meeting introduced other FPA notables.

He said that, based on interest shown, the committee would pro­ceed at once toward a meeting for the a ctual organization of the NIH/ NIMII chapter of FPA.

I At the clinical 1·esearch center,

Dr. Chisolm treats victims with two chelating agents in combination. These agents, known as BAL and EDTA, bind the lead in the blood and pass it out of the body.

This treatment has helped to cut the death rate for severe lead poisoning from 30 percent to less

NLM team wins championship of NIH Golf Association by beating the Mash ies one-u p in o sudden-death play-off. During the Sth year of the Associat ion, which is su pported by R&W, some 1 SO playe rs (1 2 teams) competed in weekly matches during the 2 2-week season, plus several other 18-hole outings. T rophies were presented at the annua l ba nq uet he ld jointly with the NIH Ladies Golf Association . Winn ing team members (I to r) a re: front row, Frank Poh, Jock W olk, Capt . Pa ul Kelly, Co rlton Su llivan, George Russell; secand row, Lar ry Coffin, Bob Ca pone, Art Robinson, Ron Taylor, Nate Markfield; third row, Bill Caldwell, Tom Minton, Ken Carney.

THE NIH RECORD

TB -sor

l fro elu mo on< ly,

the mo ext thE

Lal I

Dr. J ohn C. Greene, Director of the ye, Division of Dental Health, BHME, has apJ been appointed Assistant Surgean thE Gene ral, PHS. He is wide ly known os 1 co-author a nd developer of the Orol art Hygiene Index and the Simplified Orol col Hygiene Index, used by researche rs for To evaluating orol cleanliness. lea

2 Nobel Prize Winners, Drs. Leloir and Borlaug, Have Ties With NIH

Two more Nobel prize winners of 1970 have ties with N IH- Dr. Luis F. Leloir of Argentina, who won the Nobel Prize in Chemistry, and Dr. Norman A. Borlaug, winner of the Nobel Peace Prize.

Dr. Leloir was honored "for his discovery of sugarnucleotides and their role in ,the biosynthesis of carbohydrates."

His grant from NIH, now in its 18th year, is administered by the National In~titute of General Med­ical Sciences.

be! im

l eel lat thE te1

l im ms trc ele su,

Dit

pr, be the da ha tio Dr. Leloir is one of the world's

outstanding biochemists and is re<:­ognized for his co11tributions bo the trc understanding of carbohydrate me- re: babolism, according to Dr. DeWitt pr, Stetten, Director of NIGMS. da

With Institute support, Dr. Leloir has demonstrated in grell!t detail the be l>as.ic biochemical stel)S required fur er, the enzymabi.c breakdown of sugars no in the body and the s.ynthesis of glycogen and starch. i~,

'l'hese discoveries may have im- riE portant medical application.

Dr. Leloir is Director of the ln­sbituto de Invest.igaciones Bioquim- .Cu icas in Buenos Aires. Currently he mi is investigating hormonal regula- in tion of sugar metabolism and the re enzymes and coenzymes which act be on particular sugar particles, the A~ hexosephosphates.

Dr. Borlaug served on the malnu- eh trition panels of the U.S. Japan m, Cooperative Medical Science Pro- th gram in 1965 and 1966. (s

This program is now adminis- He tered by the N aitional Institute of Allergy and Infectious D-iseases in : collaboration with the National In­stitute of Arthritis and Metabolic ~u Diseases.

The American agricultural ex­p ert developed a dwarf strain of op wheat which is helping to supply ar grains to hungry nations.

tD

the 10$

!On

OS

rol rol for

of uis ;he Dr. ~he

his md of

its bhe ed-

d's ec­tihe ne­'itt

.oir the for ars of

im-

In­im-he

1la­the act the

nu­pan 'ro-

nis­' of ; in In­olic

ex­of

>ply

THE NIH RECORD

NERVOUS SYSTEM (C<mti.,.ued front Page 1)

some external mechanical device. For example, electrical l!;jgnals

from the brain could activate a me-· chanical shovel capable of liftin~ morie than could a hand-operated one. Or, such a system could direct­ly control a wheelchair.

"Actually," said Dr. Frank, "in the long range view, I think I am most excited by the p-0ssibility of extending human capability beyor.d the normal."

Lob Explores Possibilities

Dr. Frank's lab was created 3 years ago to explore possibilities of applying basic information about the nervous system.

Ultimately, the scientists hope, artificial devices can be entirely controlled by the nervous system. To do this, though, they must first learn how the brain directs motor behavior through patterns of nerve impulses.

By recording directly from brain cells of the motor cortex in animals, laboratory members are learning the properties of these firing pat­terns.

In beginning these studies, the investigators are faced with a pri­mary problem--developing elec­trodes (.to measure or stimulate electrical activity) which could be successfully implanted in the brain.

Difficult Engineering Problem This is a tremendous engineering

problem because the eleotrode must be flexible enough to move when the brain moves (so that it does not damage surrounding tissues), yet hard enough to withstand implanta­tion without bending.

Furthermore, if imp,lanted elec­trodes are found to produce tissue reactions, they or their breakdown products could possibly cause bra.in damage.

Implanted electrodes are already being used in some cases to dull ex­cruciating chronic pain or to diag­n-0se brain damage. While they may p1·oduce some damage themselves, their advantages outweigh the risks.

NINDS grantees have success­fully used an implanted rad,io trans­mitter to signal increased pressure in the brains of persons with hyd:ro­cep hal u:s. Such devices could also be used to transmit nerve signals.

Approach Doubted Other grantees are implanting

electrodes directly into paralyzed muscles in an attempt to stiimulart:e them and prevent degeneration (such as can result from a stroke). However, Dr. Frank notes that this approach may not be succesful be­cause, "I suspect that muscles re~ quire connections to healthy nerves if they are to remain functional."

Still anot:her device under devel­opment by grantees is a myoe.Jectric arm which Would use electrical po-

November 10, 19i0

Dr. Wiley H. Mosley (center) receives the PHS Meritorious Se rvice Medal from Dr. Robert Q. Marston, NIH Director. Dr. Mosley, chief of the Epidemiology Section of NIAID's Pakiston-SEATO Cholera Research Loborotory in Dacco, East Pakistan, was give n the oword for "his significant contributions to knowl­edge of the immunology and epidemiology of cholera resu !ting from his out­stonding ond dedicated work." Atte nding the cere mony was his fothe r, Dr. Kirk T. Mosley, who is associoted with the Ford Foundation in Calcutta, India.

Swedish Council Offers 2 Research Fellowships The Swedish Medical Research

Council is sponsoring two postdoc­toral research fellowships-to be awarded in 1971 to qualified bio­medical scientists who are U.S. citi­zens.

The fellowships will cover 12 months of research training in basic or clinical sciences in a Govern­ment-supported institution in Swe­den.

To be eligible, candida.tes must have done independent research in one of the health sciences for ad: least 2 of the last 4 years.

Aptitude Must Be Shown Evidence of research and apti­

tude ma.y be demonstrated in the form of a scientific bibliogra­phy, reports of seientific publica­tions, and references from pe1-sons familiar wibh the applicant's back­ground.

Applicants must also show that they have been accepted by a Swed­ish training institubion and by a p:recepbor.

A Facilities Oommitment Sbate-

tentials from surrounding muscles to control movemen,t of the hand 01· arm.

Such devices are thought to hold great promise because the wearer would merely attempt to make the same motions as if he had a normal limb.

For more complex control de­vices, Dr. Frank indicates that the wearer will have to learn a code of specific muscle or nervous activity.

ment must clearly state that the Swedish institution will provide facilities for the duration of the Fellow's stay.

The stipend will amount to $5,500 or $6,000, depending on the scien­tist's qualifica.tions and experience. Fellows wil also receive an addi­tional $,500 per year for ea.ch de­pendent whether that dependent goes to Sweden or remains in the United States.

The council will reimburse Fel­lows for round-trip travel costs for themselves and their immediate families. During their stay they may also accept sabbatical salary, royalties, or other income if r e­p-0rted in the application.

Scientists may obtain application forms and further information from the International Fellowships Sec­tion, Fogarty International Center,

Page 7

Artificial Kidney-Chronic Uremia Procee dings List Promising Innovations

Proceedings of the third annual meeting of Artificial Kidney-Chron­ic Uremia Program contractors held las:t January has been published by the National Institute of Arthritis and Metabolic Diseases.

The publication highlights re­search accomplishmeruts in principal areas of the program including:

Progrom Areas Listed Membranes a.nd ma.ss transfer;

hardware and instrumentation; blood cannulas and biologically compatible materials, and toxic factors in w·emia, dietary manage­ment of chronic end-stage renal disease, and clinic~! studies in ure­mia.

Innovations included a,i·e: devel­opment of a new generation of com­pact artificial kidneys, the so-called "hollow fiber dialyzers ;" easy-to­use preste.rilized "envelope dialyz­ers," and a clinicially successful method of automated peritoneal di­alysis with pennanently implanted access devices to the abdominal cavity.

Also, an inexpensive method of manufacturing dialyzers- which up to now have been expensive­through pressUJ'e molding in the fa:shion of phonograph records, and the first successful dialysis of pa­tients with membranes other than cellophane.

The proceedings are being dis­tributed to persons employed in relevant fields. Since they weI-e first issued in 1968, the proceedings have become de'finitive source material.

NIH, Bethesda, Md. 20014. Forms must be completed and re­

turned to the Fogarty Center on or before Feb. 1, 1971.

Final selection will be made at the April 1971 meeting of the Swed­ish :\fe<lical Research Council.

"One important key," he ex-• plained, "is ,to find out if man can learn to control the activity of in­dividual nerve cells. Once this can be done on a broad scale, the pos­sibilities for neural control of ex­oornal devices are unlimited."

Clinical Center staff members enjoy the annual Appreciation Porty given by Nursing Department supervisory personnel. L to r are: Geroldine Ellis, Adam Chornesky, Mildred Claasen, Virginia Murphy, Morgoret Wilt, and Rosalie Winkler. This year the Halloween spirit enlivened the occasion-complete with fresh cider, ginge rbread, doughnuts, and apples .

November 10, 1970 THE NIH RECORD

On the United Nations' 2Sth Annive rsary, Oct. 24, the Fogarty International Center gove an informal reception for NIH Visiting Scientists and International Postdoctoral Fellows. It enabled the foreign scientists ot NIH to get to know

each other ond the FIC staff, ond become better ocquointed with the Center's facilities. About 120 scie ntists, their wives, and children attended the reception at the Inte rnationa l Visitors Center, Bldg. 16A.

Lyman Moore Appointed Executive Officer, NHLI

Chemotherapists Report On 2 Anticancer Drugs Dr. Dorfman Receives Award for His Research Supported by NICHD

Appointment of Lyman !\foore as executive officer of t he National Hear-t and Lung Institute was re­cently announced by Dr. Theooore Cooper, l ns,t;atute Director.

After receiving his B.A. degree fre>m Princeton University in 1936, Mr . Moore serve,d for a year as assistant in Instruction at the Uni­ve;rsity's Woodrow Wilson School of Public and I nternational Affail'S.

He served for 2 years as program officer of International Rouse in Kew York City, thtm entered the University of Minnesota, where he earned his M.A. in 1940.

That same year Mr. Moore joined the Bureau of the Budget. Subse-

Mr. Moore has been active in the youth hoste ling moveme nt and is cur­rently Notional President of Americon Youth Hostels.

quently he held numerous adminis­trative posts in HEW.

In addition to his Federal service, Mr. Moore has been a management consultant to a private firm a11d a professorial lecturnr at American University.

His profession.al affiliations in­clude the Society for the Advance­ment of Management, of which he was vice president for membership

A conference to advise practicing physiciians on research reeults achieved wibh the anticancer drugs ortho pa.ra'-DDD and mithramycin was sponsored by the Chemother­apy Program, National Cancer In­stitute, Nov. 5-6 in the Jack Masur Auditorium of t he Clinical Center.

Both of these anticancer drugs were a,p proved earlier this year as prescription drugs by the Food and Drug Administrat:Jion.

Ortho pa.ra'-DDD or mitlotane is marketed as "Lysodren" by Calbio­chem for use in advanced cancer of the adrenal gland. Mibhramycin, useful in some cases of inoperable canoor of the testes, is produced b~• Chas. Pfizer & Co. under the trade name "l\fithracin."

The opening session, devoted to the antibiotic mithramycin, was chair ed by Dr. C. Gordon Zubrod, scientific director for ChemoVher­apy, NCI. Evaluaitions of the drug in testicular cancer, in Paget's dis­ease of the bone, and in problems of calcium imbalance were pre­sented.

Dr. Stephen K. Carter, chief of the Cancer Therapy EvaJuaition Branch, moderated an afternoon symposium on the therapy of testi­cular tumors, including treatment with surgery, radiothera.py, and drugs.

A series of reports on the devel­opment and use of ortho pa.ra'­DDD, a drug related to the insecti­cide DDT, ·was also presented.

This included a description of the effects of the drug in advanced can­cer of the adrenal oortex and in Cushing's disease, a rare disease of abno1·mal growth chm:•acteristics

(1966-68), vice-president for In­tersociety Relations (1968-69), and past president of the Washington chapter.

He is also a fellow of the Amer­ican Public Health Assooiation and a member o:f other public and health administration societiies.

sometimes due to an adrenal tumor. The session was chaired by Dr.

Saul A. Shepartz, associate scien­tific tl.ire,~tor and chief, Cancer Chemotherapy National Service Center.

Drs. Benditt and Riley Join NIEHS Committee

Drs. Earl Philip Benditt and Richard Loi-d Riley have been ap­pointed to the Environmental Health Seiences Advisory Commit­tee for terms ending June 30, 1974.

Dr. Benditt is chairman of the Department of Pathology in the School of Medicine at the Univer­sity of Wa&hingbon.

He served on the editorial board of Laborntory Inve.~tigation in 1962, on Journnl of Experimentnl and Molecular Pcithology from 1962 to the present, and as editor of Electron Mieroscovic .Atlas of Pntho/oyy in 1066.

Dr. Riley is professor of En­vironmental Medicine in the School of Hygiene and Public Health at Jolms Hopkins University.

He has held positions at Colum-

Dr. Albert Dorfman, NICHD grantee and Director of a center supported by NIH, has received the annual Borden Award.

The award, for outstanding achievement in research relating to nutrition and/ or t he develop,ment of infants and children, consists of $1,000 and a gold medal.

Dr. Dorfman is professor and chairman of the Department of Pediatrics, University of Chicago Pritzker School of )'.iedicine.

He is also Director of the Joseph P. Kennedy, Jr. Mental Retardation Research Center in Chicago. The center was const ructed with NIH funds, and is supported by tJhe Na­tional Institute of Child Health and Human Development.

Dr. Dorfman has provided a greater understanding of the mo­lecular biology of connective tissue and its causative relationship to a variety of genetic disorders.

bia University, Bellevue Hospital, New York, and t he Institute of In­dustrial Medicine at N.Y.U.

TO JOI N THE " DAVIS PLAN" -- make a Clinical Center patient's life happier

during the Christmas holidays, and all through the year -- please use this form.

Gifts are ta>< deductible.

Encle>sed is a gift of S--• (Make checks payable to NIH Patient Welfare

Fund. )

Send to: Mr. James Davis, director, Office of Administrative Services, Bldg. 31, Room 1C02 -- or Mr. John Roatch, chief, Social Work Department, Clinical Center, Room lN-250.

Donor's name: _______________________ _

Inst itute/Division: ___ ________________ __ _

Bldg. & Room No.: _____________ _____ _ __ _

Instead of shopping for Christmas cords for colleagues, NIH employees are urged to ioin the " Oavis Pion." This form was designed to moke donating thot money to the CC Pat ie nt Welfare Fund eas ier.