Novel algae sourced ingredients for immune health supportMarket and Markets Dietary Supplement...

© Kemin Industries, Inc. and its group of companies 2019. All rights reserved. ® TM Trademarks of Kemin Industries, Inc., U.S.A. Certain statements may not be applicable in all geographical regions.

This product falls within the scope of the EU Novel Food Regulation and requires authorization in order to be commercialized in Europe. Please contact us for more details.

This business to business communication is not intended to be directed to the final consumer.

Novel algae sourced ingredients for

immune health support

Food Matters Live, London – November 20th, 2019

Samanta MaciSr. Commercial & Technical Manager

Kemin Human Nutrition and Health Europe




OUTLINE

• The global immune health market opportunity

• Beta glucan for immune health

• Science behind BetaViaTM




$25BILLION

in 2025

Image source: Shutterstock 180365717

Information source: Persistence Market Research Ltd., 2017.

Market and Markets Dietary Supplement Ingredients 2018

2017

2025

$25

Billion

$14.4BILLION

Projected Global Growth of the Immune Supplement Market




Why the immune health surge?

Image source: Shutterstock. 556492396

Market and Markets Dietary Supplement Ingredients 2018

• In Europe

• Increased consumer awareness around health and wellness

• Strong demand for food supplements from Western EU

countries such as Germany, France, Italy, and the UK.

• The strongest growth is observed in Eastern European

countries, such as Poland, Romania, and Slovakia

• Aging population – by 2050 30% of the European population is

expected to be 65y or older

• Antimicrobial resistance is a growing concern in Europe




Supplement use in Europe (France, UK)

Intended Use

Question: For which indication(s) have you already used food supplements? (base is the population that has already taken supplements)Based on the French market

1,Opinion way - Les Français et les compléments alimentaires– Janvier 2019

2, Food Supplements Consumer Research. UK 2018

“One of the most commonly

given reasons was for an extra

“boost” or to top up general

health. It was felt that taking

vitamins might help to build

immunity to illnesses, for

example, help to stave off colds.”Food Supplements Consumer Research. UK 2018

38%

36%

26%25%

22%

19% 19%18%

0%

5%

10%

15%

20%

25%

30%

35%

40%

Reinforce our

natural defenses

More vitality Hair and Skin Sleep Stress Respiratory

tracts (cold,

bronchus, ...)

Joint problems Digestion




Beta glucans for immune health

• Beta glucans have shown to prime immune cells to keep the

immune system functioning at its best

• In a Kemin-sponsored survey, consumers had low awareness

of beta glucans as an immune health ingredient but high

purchase intent after aided awareness

Image source: Shutterstock 476533483.

Information source: Bailey, R.L., et al. JAMA internal medicine, 2013. RTi BetaVia Immune Health A&U Study, 2017.

Kemin-sponsored Survey of 1,200 U.S. supplement users, 2017




Shutterstock: 114121000, 422627014, 139168634, 425091133,

Information sources: Bacic, A et al. (2009).

What are

Glucose polymers present in algae,

bacteria, fungi and plants like

oats and barley.

Consists of glucose residues

connected through glycosidic

bonds.

Image source: Shutterstock 139168634.




β-Glucan in Cell

Image source: Shutterstock. Image source: Shutterstock 114121000, 422627014, 425091133Information sources: Bacic, A et al. (2009); Synytsya, et al. (2014).

β-Glucans differs based on: structure size branching solubility (soluble or particulate)




Paramylon

Image source: Shutterstock 333502868, Kemin internal images.

Information source: Bacic, et al., 2009.

Paramylon from Euglena gracilis




Supplemental

Kemin’s BetaVia™ line is a proprietary preparation of Euglena gracilis for immune system support.

95% pure beta glucan>50% beta glucan

Natural GMO-free Allergen free Gluten free Low dose Cost-effective




How beta glucan works in the immune system

Following Betavia

ingestion beta

glucan is releasedBeta glucan

remains

undigested in

small intestine

Beta glucan is

recognized and

taken up by

immune cells

1.

2.

3.

Image source: Shutterstock. 335028533

Technical Literature: KHTL-017-149, KHTL-017-150




Kemin Source Doc TD-17-00311

IMG-KI-00631

Euglena




Summary

• In a preclinical trial, immune cells responded similarly to challenges in the presence of

BetaVia Complete and Pure or Yeast Beta Glucan

• BetaVia Pure and BetaVia Complete appear to be significantly better phagocytized by

both macrophage and dendritic cells than commercial yeast beta glucans tested.

• Data suggests that BetaVia Complete and Pure share similar immunomodulatory

properties to Yeast Beta Glucan




BetaVia Complete Clinical Trial




Study Overview

Population:

Active, Healthy Males

and Females

Duration:

90 Days

Randomized, double-blind, placebo-controlled, parallel study conducted at one site

Assessment Tool:

Wisconsin Upper Respiratory

Symptom Survey (WURSS)

KHTL-017-155 Internal Document




Study Participant Inclusion Criteria

Activity

Aerobic exercise 1.5 to

3 hours/day for 5 to 6

days per week1,2

Age

25 to 65 years

Body Mass Index (BMI)

>18 kg/m2 to <35 kg/m2

KHTL-017-155 Internal Document1Mach et al. 2017

2Gleeson et al. 2015




Vitals

Blood Draw (Safety)

Product Compliance

Product Tolerance/Perception

WURSS (Assessment)

Screening &

Baseline

Day 1 Day 90

Study Design

Day 30

WURSS (Assessment)

(No Visit)

Placebo

One 367 mg capsule of study product taken daily,

30 minutes before breakfast on an empty stomach

Medical History

Vitals Blood Draw

(Safety)





Wisconsin Upper Respiratory Symptom Survey

(WURSS-24)

Symptoms

Functional

Sick Day

Barrett 2009KHTL-017-155




Summary of Significant Findings

Fewer Self-Reported

Sick Days Fewer URTI

Symptoms

Fewer URTI

Symptom Days

Fewer URTI

Episodes

Lower Overall Severity

of URTI Symptoms


© Kemin Industries, Inc. and its group of companies 2019. All rights reserved. ® TM Trademarks of Kemin Industries, Inc., U.S.A.

Certain statements may not be applicable in all geographical regions.

This product falls within the scope of the EU Novel Food Regulation and requires authorization in order to be

commercialized in Europe. Please contact us for more details.


Sick DaysSelf reported as ill on the WURSS





BetaVia Complete Helps Reduce Sick Days

People who consumed BetaVia

Complete had 3.3 fewer self-reported

sick days when compared to placebo

over 90 days

The statistical difference between

groups was seen as early as 30 days

and sustained through 90 days

KHTL-017-155






Number of URTI Symptoms


URTI Symptom DaysTotal days with at least one URTI symptom

Global Severity (Area Under the Curve)

Total severity of symptoms over timePicture of frequency, duration, and severity




BetaVia Complete Helps Reduce URTI Symptoms


Complete reported 30 fewer symptoms

over 90 days which is 70% fewer

symptoms when compared to placebo

The statistical difference between groups

was seen as early as 30 days and

sustained through 90 days

KHTL-017-155





BetaVia Complete Helps Lower URTI Symptom Days


Complete had 10 fewer URTI

symptom days when compared

to placebo over 90 days

KHTL-017-155




BetaVia Complete Helps Lower Global Severity

Global severity was 80% lower in the

BetaVia Complete group compared to the

placebo group as assessed by total AUC

for the WURSS-24 daily symptoms

The statistical difference between groups

was seen as early as 30 days and

sustained through 90 days

KHTL-017-155






URTI EpisodesSudden appearance of 1 or more symptoms with

at least 2 days of ‘not sick’ in between





BetaVia Complete Helps Reduce URTI Episodes

People who consumed BetaVia Complete

experienced 45% fewer URTI episodes

compared to placebo which is 2 fewer

episodes over 90 days

KHTL-017-155




Recap of Significant Findings

Fewer Self-Reported

Sick Days Fewer URTI

Symptoms

Fewer URTI

Symptom Days

Fewer URTI

Episodes

Lower Overall Severity

of URTI Symptoms





Safety

• BetaVia Complete was shown to be safe

• No adverse events attributed to BetaVia Complete

• BetaVia Complete was well tolerated

• Self-affirmed GRAS

KHTL-017-155




Benefits

Strengthens the body’s natural immune system

Clinically shown to provide sustained immune support

Natural immune support from Algae

Supports individual’s natural immunity during and after exercise

• Primes key immune cells

• Taken up by immune cells

• Promotes immune cell signaling

• May support a healthy gut by promoting growth of beneficial bacteria

Naturally-sourced • GMO-free • Allergen-free • Gluten-free • Low dose • Clinically Studied

THANK YOU

WWW.KEMIN.COM/HEALTH

[email protected]

Novel algae sourced ingredients for immune health supportMarket and Markets Dietary Supplement...

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