I N S I D E T H I SI S S U E

RecruitmentCountdown

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ArgentinaMeeting

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UpcomingMeetings

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Newsletterfeature

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Housekeeping... 4

Congratulationsfirst recruit

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RecruitmentExcellence

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RecruitmentTable

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2yr Follow-UpTable

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M A Y 3 1 , 2 0 1 0V O L U M E 9 , I S S U E 5

Noticias News NouvellesThe Centre for Mother, Infant, and Child Research7th Floor, 790 Bay Street Toronto ON CANADA M5G 1N8

Tel: 1 416 351 2533 Fax: 1 416 351 3771 email: tbs@sw.ca website: www.cmicr.ca

Overall Total: 2396Total this month: 42

Recruitment CountdownMay was a marvelous month for recruitment!! Congratulations to all ourcentres that recruited this month. Next month, let us try to recruit at least50!

Below is our illustration of our race to the finish. Our babies are a littlecloser to the finish line!

P A G E 2

Collaborators’ Meetings Argentina MeetingDr Mario Palermo and Dr Dolores Montes Varela of Posadas Hospital in Buenos Aireshosted a TBS meeting on April 22, 2010. This special meeting was held at thePanamericano Hotel. Below is a list of those that attended the meeting:

Australian MeetingJuly 1st, 2010 is quickly approaching and final plans areunderway! If you have not yet responded to our invitation,please do so today! We look forward to meeting ourAustralian contingent in Sydney.

North American MeetingOctober 17—18, 2010 in Banff, Canada. Invitations to this meeting will be sent in June.

Upcoming Meetings...

Luis Fernandez Miranda, Maria Cecilia Oviano, Leoliardo Mezzabotta, Carolina Reinoso,Susana Bulacio, Morina Caffoni, Analia Messina, Eugenia Arroche, M. Martha Mirabella,Carlos Arias, Elba Mirta Morales, Ana Maria Catalini, Alberto Chait, Natalia Fiorillo,Armondo Dunaiewsky, Mara Mohedano, Elba Latouche, Raul Abalos, Claudio Siamarella,Ramon Miguel Valparaiso, Cristina Laterra, Sandra Susacasa, Victoria Bertolino, HildaFernandez, Graciela Lombarte, Marcelo Gonzalez Brnal, Mabel Poncelas, Raquel Martin,Marta Bertin, Jorge Nejamkin, Christian Muzio, Daniela Gonzalez, Daniel Aguirre, MariaJose Prieto, Liliana Voto, Carlos Becker, Ana Mezzotero, Diego Villagran, Diego Cruciani,Mutov Luckin, Luis Blanco

P A G E 3

We are proud of the 6 years of fruitful collaboration between our department andthe TBS team. During all this timespan we appreciated the good study managementwhich included us in the world wide family of TBS.

As a result of our efforts we managed to enroll 17 patients, and we met as manyhappy families.

TBS, eventually, provides a bond between obstetrician and future twin moms.The opportunity of follow-up allows us to keep in touch with moms and their children,enriching our experience. This special relationship is extended beyond the moment ofbirth.

TBS twin bears have marked different phases of the two-years follow-up,bringing everytime the smile on our faces.

Many patients agreed to be enrolled in this studygiven the possibility to be of help for future twin mothers.

Thoughtful words:Before you were conceived I wanted youBefore you were born I loved youBefore you were here an hour I would die for youThis is the miracle of life.” (Maureen Hawkins)

The team at University of Pharmacy and Medicine in Cluj-Napoca, Romania has done agreat job in consistently recruiting. In addition, they consistently return data forms andqueries on time, and overall they can boast of high quality data. The pictures belowshow the clinic and an old view of the town of Cluj-Napoca.Here is what Dr Gabriela Caracostea, the site coordinator, has to say about their partici-pation in TBS:

Newsletter Feature

P A G E 4

Housekeeping

To comply with Good Clinical Practice guidelines and to maintain confidentiality, weshould not have any identifying patient information at the Data Coordinating Centre.Identifying information is recorded on the Patient Consent forms and therefore theseforms must be kept for your records at your centre.

As a reminder, please do NOT send the Consent Forms from yourpatients to the Data Coordinating Centre.

Do Not Send Patient Consent forms...

Keep Yellow Copies...After you have completed the data forms (Entry, Labour,Delivery, Maternal, Neonatal), please remember toremove the yellow copies from the booklets. The yellowcopies should be kept in your patients’ files for your records and the white copies should be returned to theData Coordinating Centre. Please do NOT send theyellow copies to us.

P A G E 5

Congratulations on your first recruit!We would like to congratulate Dr Elena Carreras Moratonas and the teamat Hospital Vall d'Hebron, Barcelona, Spain and Dr Maria Luisa CanetePalomo and the team at Complejo Hospitalario de Toledo, Toledo, Spainand Dr Forough Radfar and the team at Khoula Hospital, Muscat, Omanon recruiting their first patient into the study. Excellent job! We lookforward to more recruits from your centres.

Recruitment ExcellenceCongratulations to Dr Jesus Daniel Aguirre and the team atHospital JR Vidal, Corrientes, Argentina; Dr Jose Luis Castaldiand the team at Hospital Penna, Bahia Blanca, Argentina; DrRaul Abalos Gorostiaga and the team at Hospital RamonCarrillo, Santiago del Estero, Argentina; Dr Diana Galimbertiand the team at Hospital Alvarez, Buenos Aires, Argentina; Dr Renato AugustoMoreira de Sa and the team at Perinatal, Rio de Janeiro, Brazil; Dr Jose GuillhermeCecatti and the team at University of Campinas, Campinas, Brazil; Dr Iracema deMattos Calderon and the team at Botucatu Medical School, Botucatu, Brazil; Dr PilleVaas and the team at Tartu University Hospital - Women's Clinic, Tartu, Estonia; DrMarwan Hakim and the team at Nazareth Hospital (EMMS), Nazareth, Israel; and DrDonnette Simms-Stewart and the team at University Hospital of the West Indies,Kingston, Jamaica.

Keep up the excellent work! We will be sending a gold seal to place on yourCertificate of Achievement.

Twin Birth Study

May 31, 2010

DecJan -Dec

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Jan -Jun

Jul -Dec

Jan -Feb Mar Apr May Grand

2003 2004 2005 2006 2007 2008 2009 2009 2010 2010 2010 2010 TotalCOUNTRYARGENTINA 63 60 65 96 107 122 65 60 23 15 11 9 633BRAZIL 73 2 44 71 54 63 42 55 14 8 6 12 371CANADA 81 3 25 53 46 41 29 22 18 2 2 1 1 243ISRAEL 46 21 27 16 14 32 15 27 7 5 2 3 169POLAND 15 4 28 18 44 35 14 11 3 1 4 162UK 63 2 2 15 18 16 11 20 8 1 2 3 98CHILE 16 8 11 13 8 16 21 4 9 1 1 1 93EGYPT 20 19 14 15 6 12 11 9 2 1 89AUSTRALIA 32 2 15 12 17 14 5 3 1 5 1 1 76SERBIA 11 27 15 9 2 1 54USA 31 4 13 10 8 5 11 1 1 53THE NETHERLANDS 10 7 9 17 6 6 3 2 2 1 53ESTONIA 3 5 12 8 7 7 5 2 1 1 2 1 51SPAIN 17 2 6 10 9 8 5 2 2 1 1 2 48JAMAICA 4 23 14 3 4 3 1 48JORDAN 9 5 5 8 9 8 4 2 1 5 1 48HUNGARY 4 5 11 6 3 5 4 1 1 1 37ROMANIA 3 2 5 2 4 3 1 17BELGIUM 0 5 7 3 15GERMANY 9 3 4 4 3 1 15CROATIA 0 4 3 2 9OMAN 7 5 5QATAR 22 3 2 5GREECE 0 1 3 4Total 539 3 182 333 373 385 425 246 241 78 49 39 42 2396

CENTRES BY COUNTRY (Shaded area is prior to start-up)

ARGENTINAHospital LC Lagomaggiore, Mendoza 12 31 32 27 22 25 12 14 1 2 3 1 170Hospital Posadas, Buenos Aires 6 22 28 17 19 6 11 4 4 3 1 115Hospital Ramon Carrillo, Santiago del Estero 10 2 15 19 28 18 18 2 4 3 3 112Hospital Avellaneda, Tucuman 6 2 11 13 13 6 4 5 1 2 57Hospital JR Vidal, Corrientes 6 4 10 18 7 7 2 3 1 3 55Hospital Penna, Bahia Blanca 4 12 10 6 3 4 1 36Hospital Sarda, Buenos Aires 10 3 5 11 6 5 3 1 1 35Hospital Angela Iglesia de Llano, Corrientes 3 5 9 2 2 2 1 21Hospital Juan A Fernandez, Buenos Aires 4 12 1 1 14Hospital Alvarez, Buenos Aires 2 1 2 4 1 8Centre(s) that are no longer recruiting 0 10

BRAZILUniversity of Campinas, Campinas 5 2 17 15 17 13 11 5 2 1 2 85Maternidade Escola da UFRJ, Rio de Janeiro 6 8 16 18 14 7 8 2 2 2 77University of Pernambuco, Recife 7 13 14 10 17 1 1 56Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 8 18 3 2 3 2 28Hospital Universitario de Jundiai, Jundiai 5 13 9 3 1 26Hospital Sao Lucas, Porto Alegre 5 5 3 8 2 1 3 2 24Hospital Universitario Antonio Pedro, Niteroi 5 1 10 5 2 2 1 1 22Perinatal, Rio de Janeiro 8 8 3 1 1 1 2 16ISCMPA-Maternidade Mario Totta, Porto Alegre 6 5 4 3 1 13Botucatu Medical School, Botucatu 2 4 2 2 2 10Hospital das Clinicas da UFPE, Recife 5 4 1 2 7Hospital Materno Infantil, Goiania 3 2 2 2 6Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 8 1 1

Recruitment(Projected sample size of 2800)

AnnualGoal

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2003 2004 2005 2006 2007 2008 2009 2009 2010 2010 2010 2010 TotalAnnual

GoalCANADASunnybrook Health Sciences Centre, Toronto 5 3 14 11 13 18 8 5 4 1 1 1 79IWK Health Centre, Halifax 7 1 4 6 4 6 3 3 27Regina General Hospital, Regina 5 5 7 3 2 2 4 23Trillium Health Centre, Mississauga 6 6 4 6 1 17Lions Gate Hospital, Vancouver 3 6 1 2 1 1 1 12Foothills Medical Centre, Calgary 7 1 5 1 1 1 9St Joseph's Health Care, London 9 1 3 3 1 8SMBD Jewish General Hospital, Montreal 6 2 4 2 8Royal University Hospital, Saskatoon 6 4 1 1 6Royal Columbian Hospital, New Westminster 5 3 3 6North Bay General Hospital, North Bay 2 3 2 5Women’s Health Centre, St John's 4 1 2 3Toronto East General, Toronto 5 1 1 1 3Children's & Women's Health Centre of BC, Vancouver 11 1 1Centre(s) that are no longer recruiting 0 36

ISRAELNazareth Hospital (EMMS), Nazareth 3 18 6 13 3 3 1 2 46Ma'ayney HaYeshua Medical Center, Bnei Brak 10 5 4 5 4 5 3 5 1 32Edith Wolfson Medical Center, Holon 5 11 6 6 4 2 1 1 31Holy Family Hospital, Nazareth 3 2 8 3 1 14HaEmek Medical Center, Afula 7 1 7 2 2 1 13Poriya Government Hospital, Tiberias 4 3 3 1 4 1 12Bnai Zion Medical Center, Haifa 8 4 7 11Hillel Yaffe Medical Center, Hadera 6 3 3 2 1 1 10

POLANDUniversity School of Medical Sciences, Poznan 8 3 24 15 33 26 12 10 3 1 1 128Polish Mothers Memorial Hospital, Lodz 5 1 2 10 8 2 3 26Medical University of Gdansk, Gdansk 2 1 3 1 1 1 1 8

UKBradford Royal Infirmary, Bradford 8 8 4 2 4 11 1 1 31Nottingham City Hospital, Nottingham 9 2 2 3 2 7 1 4 21Basildon & Thurrock University, Basildon 6 1 5 3 1 10Liverpool Women's Hospital, Liverpool 12 6 2 1 9Derriford Hospital, Plymouth 6 1 2 1 1 3 8Queens Medical Centre, Nottingham 6 4 2 1 7Queen Elizabeth Hospital, King's Lynn 3 3 2 5University Hospital of North Staffordshire, Stoke-on-Trent 8 3 1 4Lewisham Hospital, London 5 3 3

CHILEHospital Dr Gustavo Fricke, Vina del Mar 5 8 11 8 6 12 8 3 5 1 1 1 64Hospital Dr Sotero del Rio, Puente Alto 11 5 2 4 13 1 4 29

EGYPTAssiut University Hospital, Assiut 20 19 14 15 6 12 11 9 2 1 89

AUSTRALIAIpswich Hospital, Ipswich 3 1 12 9 1 1 2 26Mater Mothers' Hospital, Brisbane 6 2 3 3 1 5 1 3 1 19St George Hospital, Sydney 3 2 5 1 3 1 12Toowoomba Base Hospital, Toowoomba 2 4 2 6Monash Medical Centre, Clayton 4 4 1 5Logan Hospital, Meadowbrook 5 3 1 4Women's and Children's Hospital, Adelaide 6 1 1 2Townsville Hospital, Townsville 3 1 1 2

SERBIAUniversity of Belgrade, Belgrade 11 27 15 9 2 1 54

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2003 2004 2005 2006 2007 2008 2009 2009 2010 2010 2010 2010 TotalAnnual

GoalUSAEast Bay Perinatal Medical Associates, Oakland 7 9 5 4 1 1 1 21University of Miami, Miami 9 1 10 11Maricopa Medical Center, Phoenix 8 3 3 2 1 9University of South Carolina, Columbia 4 1 2 3 6University of Iowa Hospitals and Clinics, Iowa City 3 1 1 2Centre(s) that are no longer recruiting 0 4

THE NETHERLANDSAtrium Medical Center, Heerlen 3 4 5 7 5 6 2 29Academisch Ziekenhuis Maastricht, Maastricht 2 3 2 1 1 1 8Sint Lucas Andreas Ziekenhuis, Amsterdam 2 4 1 5Maxima Medical Centre, Veldhoven 3 1 1 1 1 4Centre(s) that are no longer recruiting 0 7

ESTONIATartu University Hospital - Women's Clinic, Tartu 3 5 12 8 7 7 5 2 1 1 2 1 51

SPAINHospital Clinic-University of Barcelona, Barcelona 5 2 6 10 9 8 5 2 2 1 1 46Hospital Vall d'Hebron, Barcelona 5 1 1Complejo Hospitalario de Toledo, Toledo 7 1 1

JAMAICAUniversity Hospital of the West Indies, Kingston 4 23 14 3 4 3 1 48

JORDANIslamic Hospital, Amman 9 5 5 8 9 8 4 2 1 5 1 48

HUNGARYUniversity of Debrecen, Debrecen 4 5 11 6 3 5 4 1 1 1 37

ROMANIAUniversity of Pharmacy and Medicine, Cluj-Napoca 3 2 5 2 4 3 1 17

BELGIUMCentre(s) that are no longer recruiting 0 15

GERMANYLudwig Maximilians University of Munich, Munich 2 1 4 3 1 9CUB - Virchow Klinikum, Berlin 5 3 3CUB - Benjamin Franklin, Berlin 2 2 1 3

CROATIACentre(s) that are no longer recruiting 0 9

OMANKhoula Hospital, Muscat 7 5 5

QATARHamad Medical Corporation, Doha 22 3 2 5

GREECECentre(s) that are no longer recruiting 0 4

Centres awaiting first patient: [COUNTRY: Hospital, City (annual goal)] [month/year start-up package sent]

ARGENTINA: Hospital JM Cullen, Santa Fe (4) [01/10]; AUSTRALIA: Royal North Shore, St Leonards (3) [11/06]; CANADA:St Paul’s Hospital, Vancouver (3) [01/09]; UK: Aberdeen Maternity, Aberdeen (6) [11/06]; USA: Washington University, St Louis (5) [01/07];

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TBS 2 Year Follow-upThe status of the TBS 2 Year Follow-up is displayed in the following table for centres that recruited patients. Centresare listed according to the total number of recruits by country and centre. See below for the number of follow-upassessments performed by your centre!

Let's aim for 100% follow-up!!

Follow-Up Status

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COUNTRYARGENTINA 60 51 65 58 96 87 107 99 122 17 125 58 633 312BRAZIL 2 2 44 36 71 56 54 32 63 4 97 40 371 130CANADA 3 3 25 22 53 47 46 37 41 32 29 4 40 6 243 145ISRAEL 21 21 27 23 16 16 14 11 32 3 42 17 169 74POLAND 4 4 28 26 18 15 44 34 35 4 25 8 162 83UK 2 2 2 2 15 6 18 12 16 31 14 98 22CHILE 8 8 11 11 13 13 8 7 16 2 25 12 93 41EGYPT 19 19 14 14 15 15 6 6 12 1 20 3 89 55AUSTRALIA 2 2 15 10 12 7 17 16 14 5 8 8 76 40SERBIA 27 8 24 3 54 8USA 4 2 13 8 10 3 8 4 5 2 11 2 53 19THE NETHERLANDS 7 7 9 9 17 14 6 5 6 2 5 3 53 37ESTONIA 5 5 12 12 8 8 7 7 7 3 7 5 51 35SPAIN 2 2 6 6 10 10 9 9 8 4 7 6 48 31JAMAICA 23 15 14 2 7 4 48 17JORDAN 5 5 5 5 8 8 9 9 8 6 7 48 27HUNGARY 5 5 11 4 6 3 5 5 2 37 9ROMANIA 2 2 5 5 2 2 4 4 3 2 1 17 15GERMANY 3 2 4 4 4 2 3 1 15 8BELGIUM 5 4 7 7 3 2 15 13CROATIA 4 4 3 2 2 2 9 8OMAN 5 5QATAR 5 5GREECE 1 3 4Total 3 3 182 167 333 287 373 305 385 304 425 63 487 208 2396 1129

100.0% 91.8% 86.2% 81.8% 79.0% 14.8% 47%

CENTRES BY COUNTRY (Shaded area is prior to start-up)

ARGENTINAHospital LC Lagomaggiore, Mendoza 31 27 32 31 27 27 22 22 25 7 26 7 170 114Hospital Posadas, Buenos Aires 22 22 28 23 17 17 19 18 6 1 15 8 115 81Hospital Ramon Carrillo, Santiago del Estero 2 2 15 15 19 19 28 7 36 12 112 43Hospital Avellaneda, Tucuman 2 2 11 11 13 12 13 10 8 57 25Hospital JR Vidal, Corrientes 4 4 10 6 18 14 9 55 10Hospital Penna, Bahia Blanca 12 9 10 8 6 3 5 36 17Hospital Sarda, Buenos Aires 3 5 5 11 2 11 5 35 7Hospital Angela Iglesia de Llano, Corrientes 5 4 9 9 2 2 3 21 13Hospital Juan A Fernandez, Buenos Aires 12 2 14Hospital Ramos Mejia, Buenos Aires 7 2 1 2 10 2Hospital Alvarez, Buenos Aires 1 6 1 8

BRAZILUniversity of Campinas, Campinas 2 2 17 11 15 6 17 2 13 2 16 5 85 23Maternidade Escola da UFRJ, Rio de Janeiro 8 8 16 15 18 16 14 15 6 77 39University of Pernambuco, Recife 13 12 14 13 10 9 17 2 2 56 36Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 18 10 28Hospital Universitario de Jundiai, Jundiai 22 4 26Hospital Sao Lucas, Porto Alegre 5 11 8 24Hospital Universitario Antonio Pedro, Niteroi 1 1 10 10 5 4 2 2 2 22 15Perinatal, Rio de Janeiro 8 8 3 1 1 2 2 16 9ISCMPA-Maternidade Mario Totta, Porto Alegre 5 4 4 4 3 1 13 8Botucatu Medical School, Botucatu 4 4 2 10Hospital das Clinicas da UFPE, Recife 4 1 2 7Hospital Materno Infantil, Goiania 2 4 6Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 1 1

CANADASunnybrook Health Sciences Centre, Toronto 3 3 14 14 11 10 13 12 18 16 8 9 3 79 55IWK Health Centre, Halifax 1 1 4 4 6 6 4 4 6 1 6 27 16McMaster University Medical Centre, Hamilton 10 10 7 7 4 4 4 1 25 22Regina General Hospital, Regina 5 4 7 7 3 2 2 6 23 13Trillium Health Centre, Mississauga 6 4 4 6 3 1 17 7Lions Gate Hospital, Vancouver 6 6 1 1 2 1 2 1 12 8Mount Sinai Hospital, Toronto 5 3 2 1 3 3 10 7Foothills Medical Centre, Calgary 1 1 5 4 1 1 1 1 9 6St Joseph's Health Care, London 1 6 1 8SMBD Jewish General Hospital, Montreal 2 4 2 8Royal Columbian Hospital, New Westminster 3 3 3 3 6 6Royal University Hospital, Saskatoon 4 1 1 1 6 1North Bay General Hospital, North Bay 5 5Women’s Health Centre, St John's 1 1 2 2 3 3Toronto East General, Toronto 1 1 1 1 3 1York Central Hospital, Richmond Hill 1 1Children's & Women's Health Centre of BC, Vancouver 1 1

ISRAELNazareth Hospital (EMMS), Nazareth 18 19 9 46Ma'ayney HaYeshua Medical Center, Bnei Brak 5 5 4 4 5 5 4 1 5 8 1 32 15Edith Wolfson Medical Center, Holon 11 11 6 6 6 6 4 4 2 2 2 31 29Holy Family Hospital, Nazareth 10 4 14HaEmek Medical Center, Afula 1 1 7 6 2 2 2 2 1 13 11Poriya Government Hospital, Tiberias 3 3 3 1 1 4 1 12 4Bnai Zion Medical Center, Haifa 4 4 7 7 11 11Hillel Yaffe Medical Center, Hadera 3 3 3 1 2 2 10 4

POLANDUniv School of Medicine, Poznan 3 3 24 24 15 14 33 33 26 4 22 5 128 78Polish Mothers Memorial Hospital, Lodz 1 2 10 8 2 3 26Medical University of Gdansk, Gdansk 1 1 3 2 1 1 1 1 1 1 8 5

UKBradford Royal Infirmary, Bradford 8 4 4 3 2 15 2 31 7Nottingham City Hospital, Nottingham 2 2 2 2 3 2 2 2 7 1 4 21 8Basildon & Thurrock University, Basildon 1 5 4 3 1 10 4

2003 2004 2005 2006 Totals2007 2008 2009 2010

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Follow-Up Status

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2003 2004 2005 2006 Totals2007 2008 2009 2010

Liverpool Women's Hospital, Liverpool 6 3 9Derriford Hospital, Plymouth 1 1 2 2 3 8 1Queens Medical Centre, Nottingham 6 1 7Queen Elizabeth Hospital, King's Lynn 3 2 2 5 2University Hospital of North Staffordshire, Stoke-on-Trent 3 1 4Lewisham Hospital, London 3 3

CHILEHospital Dr Gustavo Fricke, Vina del Mar 8 8 11 11 8 8 6 6 12 1 11 8 64 34Hospital Dr Sotero del Rio, Puente Alto 5 5 2 1 4 1 14 4 29 7

EGYPTAssiut University Hospital, Assiut 19 19 14 14 15 15 6 6 12 1 20 3 89 55

AUSTRALIAIpswich Hospital, Ipswich 1 1 12 12 9 3 1 3 26 16Mater Mothers' Hospital, Brisbane 2 2 3 2 3 3 1 6 4 19 7St George Hospital, Sydney 2 2 5 5 1 1 3 2 1 12 10Toowoomba Base Hospital, Toowoomba 4 1 2 6 1Monash Medical Centre, Clayton 4 2 1 5 2Logan Hospital, Meadowbrook 3 1 1 1 4 2Women's and Children's Hospital, Adelaide 1 1 2Townsville Hospital, Townsville 1 1 1 1 2 2

SERBIAUniversity of Belgrade, Belgrade 27 8 24 3 54 8

USAEast Bay Perinatal Medical Associates, Oakland 9 5 5 1 4 1 2 21 6University of Miami, Miami 1 10 11Maricopa Medical Center, Phoenix 3 2 3 2 2 1 9 4University of South Carolina, Columbia 1 1 2 2 3 3 6 6Texas Tech UHSC, Lubbock 2 2Jamaica Hospital Medical Center, Jamaica 2 2 2 2University of Iowa Hospitals and Clinics, Iowa City 1 1 1 2 1

THE NETHERLANDSAtrium Medical Center, Heerlen 4 4 5 5 7 7 5 4 6 2 2 29 22Academisch Ziekenhuis Maastricht, Maastricht 3 3 2 2 1 1 1 8 5Maaslandziekenhuis Sittard, Sittard 2 2 5 5 7 7Sint Lucas Andreas Ziekenhuis, Amsterdam 4 2 1 1 5 3Maxima Medical Centre, Veldhoven 2 2 4

ESTONIATartu University Hospital - Women's Clinic, Tartu 5 5 12 12 8 8 7 7 7 3 7 5 51 35

SPAINHospital Clinic-University of Barcelona, Barcelona 2 2 6 6 10 10 9 9 8 4 7 4 46 31Hospital Vall d'Hebron, Barcelona 1 1Complejo Hospitalario de Toledo, Toledo 1 1

JAMAICAUniversity Hospital of the West Indies, Kingston 23 15 14 2 7 4 48 17

JORDANIslamic Hospital, Amman 5 5 5 5 8 8 9 9 8 6 7 48 27

HUNGARYUniversity of Debrecen, Debrecen 5 5 11 4 6 3 5 5 2 37 9

ROMANIAUniversity of Pharmacy and Medicine, Cluj-Napoca 2 2 5 5 2 2 4 4 3 2 1 17 15

GERMANYLudwig Maximilians University of Munich, Munich 1 1 4 4 3 2 1 9 7CUB - Virchow Klinikum, Berlin 3 3CUB - Benjamin Franklin, Berlin 2 1 1 3 1

BELGIUMVrije Universiteit Brussel, Brussels 5 4 7 7 3 2 15 13

CROATIASveti Duh Hospital, Zagreb 4 4 3 2 2 2 9 8

OMANKhoula Hospital, Muscat 5 5

QATARHamad Medical Corporation, Doha 5 5

GREECEAlexandra Maternity, Athens 1 3 4

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