Northwest-Alaska Pharmacogenomics Research Network“Pharmacogenetics in Rural and Underserved Populations”

Kenneth Thummel1 and Wylie Burke2

Depts. of Pharmaceutical Sciences1 and Bioethics & Humanities2, University of Washington, Seattle, WA

Clinical/Translational

Tamoxifen – CYP2D6 Genotype-Pharmacokinetics (PK) Relationship

(Aim 2A; UM, SCF, UW)

Tacrolimus – CYP3A Genotype-PK Relationship (Aim 2B; UW, SCF, UM)

Warfarin – CYP2C9, CYP4F2, VKORC1, GGCX Genotype-Pharmacodynamic

Relationships (Aim 2C; SCF, UW)

Warfarin – Gene variation penetrance as a function of rural vs. urban INR monitoring

(Aim 4A; GHRI, UW)

Assessment & Capacity Development

Focus groups/consultation with AI/AN community members; health care provider deliberation (Aim 1A; UM, SCF, UAF, UW)

Develop infrastructure to track adverse drug reactions in rural NW/Alaska for

pharmacogenomic studies (Aim 4B; UW ITHS – WWAMI)

Discovery

SNP Discovery – CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP4F2, VKORC1, GGCX (Aim 1B; UM, SCF, UAF, UW)

Gene-Diet Interactions/Cell-based systems (Vitamin K, PUFAs)

(Aim 3; UAF, UW, PSBC)

People in Rural and Urban Washington and Idaho

Dual Principal InvestigatorsKen Thummel, Wylie Burke

Program CoordinatorBarbara Kavanaugh

Dual Principal InvestigatorsKen Thummel, Wylie Burke

Program CoordinatorBarbara Kavanaugh

University of Washington

Allan Rettie*Dave Veenstra

Dave BloughHelene Starks

Rose James

Mark Rieder, Melissa Austin, Alfred Berg, Kari Stephens, Connie Davis, Ron Whitener

University of Washington

Allan Rettie*Dave Veenstra

Dave BloughHelene Starks

Rose James

Mark Rieder, Melissa Austin, Alfred Berg, Kari Stephens, Connie Davis, Ron Whitener

Center for Alaska Native Health Research (CANHR)

University of Alaska - Fairbanks

Bert Boyer*Scarlett Hopkins

Diane O’Brien

Center for Alaska Native Health Research (CANHR)

University of Alaska - Fairbanks

Bert Boyer*Scarlett Hopkins

Diane O’Brien

University of Montana

Erica Woodahl*Liz Putnam

LeeAnna MuzquizMark Pershouse

Pat Beatty

University of Montana

Erica Woodahl*Liz Putnam

LeeAnna MuzquizMark Pershouse

Pat Beatty

ResourcesGene Resequencing CenterFunctional Genomics LabMass Spectrometry Center

ResourcesGene Resequencing CenterFunctional Genomics LabMass Spectrometry Center

Southcentral Foundation

Denise Dillard*Douglas Eby

Brian Schilling

Southcentral Foundation

Denise Dillard*Douglas Eby

Brian Schilling

ResourcesAlaska Stable Isotope Facility

CANHR Culture Intervention Core

ResourcesAlaska Stable Isotope Facility

CANHR Culture Intervention Core

Group Health Research Institute

Denise Boudreau*Monica Fujii

Group Health Research Institute

Denise Boudreau*Monica Fujii

Puget Sound Blood Center

John Kulman*

Puget Sound Blood Center

John Kulman*

GOALS• To develop collaborative approaches for improving the diversity of populations participating in PGx

research, particularly American Indian and Alaska Native people.

• To evaluate opportunities for PGx to benefit rural and underserved populations, which traditionally have been understudied, yet may have more to gain clinically and economically from selected PGx applications.

GOALS• To develop collaborative approaches for improving the diversity of populations participating in PGx

research, particularly American Indian and Alaska Native people.

• To evaluate opportunities for PGx to benefit rural and underserved populations, which traditionally have been understudied, yet may have more to gain clinically and economically from selected PGx applications.

* Lead Co-Investigator

U01 GM092676