Normal Structure & Function of Musculoskeletal Tissues CIA
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Transcript of Normal Structure & Function of Musculoskeletal Tissues CIA
Normal Structure & Function of Musculoskeletal Tissues
Normal Structure & Function of Musculoskeletal TissuesSalter readingBy Dina Aprilya1
2 points of view9/16/[email protected] FrameworkLever for the Locomotor systemProtection for visceraHaemopoetic tissueHomeostasis of Mineral2Embryonic development of bones9/16/[email protected]/16/[email protected]
9/16/[email protected]/16/[email protected]
The hyaline cartilage model9/16/[email protected] week 6th weekMesenchymal ModelCartilaginous Model7Calcification of the cartilage7th weekHypertrophy cartilageCalsification of matrixDead cartilage cellsVascular CT bringing osteoblast
9/16/[email protected] ossification increase bone diameter.
8Medullary cavity develops
6th month Tubulation Medullary Cavity
Newborn epyfisisendochondral ossification 9/16/[email protected]
secondary ossificationcentre9Bone growth & Remodelling9/16/[email protected] growth in Length
9/16/[email protected] epiphysis to epiphysial plate,
immature cells,rich vascular
Most activeHypertrophy, produce posphate
Calsification matrix, dead chondrocytes
Bone growth in widthAppositional growthIntramembranososus Ossification periosteumOsteoclastic resorption endoosteum
9/16/[email protected] remodelling
9/16/[email protected] of bone tissueContinuing process of oosteoblastic bone deposition n osteoclastic bone resorption13Wollfs Law : Form Follow The Function9/16/[email protected] response to physical stress14Anatomy and histology of bones as structures9/16/[email protected] StructureLong bone (tubular bone)Short bone (cuboidal bone)Flat bone
Each bone..CompactaSpongiosa 9/16/[email protected] supplyAfferentEfferentIntermediate
Blood Flow: centrifugal pattern9/16/[email protected] structureImmature boneMature Bone9/16/[email protected]
Bone Cells and Their Function9/16/[email protected]
Biochemistry and physiology of bone as an organ9/16/[email protected]/16/[email protected] cells and matrixMineralswaterCalcium and Phosphorus Metabolism9/16/[email protected] is the reservoir of 99% of the total body Calcium and 90% of the total body phosphorus
Ca10(PO4)6(OH)29/16/[email protected]/16/[email protected]
Hormonal regulationHormoneTriggerRegulationEffectPTHHypocalcemia-Bone Reabsorption-stimulate Ca Resorption by renal tubule- Inhibit renal tubule phosphate resorption plasma Ca plasma PCalcitoninHypercalcemiaDecrease bone resorption plasma CaVit D active(1,25-Dihydroxy-calciferol)HypocalcemiaHypophosphatemiaPTHintestinal absorption Ca and Pmobilization of Carenal tubular reabsorption of CaStimulate Ca binding protein synthesis in intestinal mucosa cellsDeposition of minerals in osteoidplasma Ca9/16/[email protected] AND ARTICULAR CARTILAGE9/16/[email protected]/16/[email protected] structure9/16/[email protected]
The synovial membrane9/16/[email protected] KASIH9/16/[email protected]