Normal RBC. Variation in Normal Rubriblast.
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Transcript of Normal RBC. Variation in Normal Rubriblast.
Normal RBC
Variation in Normal
Rubriblast
Prorubricyte
Prorubricyte
Rubricyte
Metarubricyte
Reticulocyte
RBC
Copyright ©2001 American Society of Hematology. Copyright restrictions may apply.
Rubriblast or Pronormoblast (Proerythroblast)
Prorubricyte (Basophilic Normoblast)
Copyright ©2005 American Society of Hematology. Copyright restrictions may apply.
Maslak, P. ASH Image Bank 2005;2005:101351
Prorubricyte or Basophilic Normoblast
Rubricyte (Polychromatophilic Normoblast)
Copyright ©2004 American Society of Hematology. Copyright restrictions may apply.Maslak, P. ASH Image Bank 2004;2004:101152
Rubricyte or Polychromatophilic Normoblast
Metarubricyte
Metarubricyte, nucleus ejected
Normochromic/Normocytic v. Hypochromic/Microcytic
Normal v IDA Maturation
Iron Deficiency Anemia (IDA)
IDA
IDA
Hypochromic RBCs
Hypochromic, Microcytic
IDA, treated
Anemia of Chronic Diseasehttp://www.brainshark.com/brainshark/vu/view.asp?pi=35105778
Normal B12 or Folate Deficient
Normocytic v. Macrocytic
Normal v B12/Folate Deficiency Maturation
Folate Deficiency, Bone Marrow
Megaloblastic Anemia, Bone Marrow
Macro Ovalocytes
Hypersegmented PMN
B12/Folate Deficiency
Pernicious Anemia
Megaloblastic Anemia
Hypochromic/Microcytic Normochromic/Normocytic Macrocytic(/Normochromic)
Macrocytic, Microcytic Normocytic
Copyright ©2005 American Society of Hematology. Copyright restrictions may apply.
Gallagher, P. G. Hematology 2005;2005:13-18
Figure 2. Pathophysiology of hereditary spherocytosis
Hereditary Spherocytosis
Normal v. Spherocytosis
Spherocytosis
Spherocytes
Normal v Ovalocyte
Hereditary Ovalocytosis
Eliptocytosis
Hereditary Stomatocytosis
Stomatocytosis
Cut by Fibrin Strands
RBC Fragmentation
Fragmented red blood cells resulting from physical trauma
Helmet Cells
Membrane damaged RBCs
Schistocytes
Burr Cells (Echinocytes)
ITP
Disseminated Intravascular Coagulation
Acanthocytes & Burr Cells
A-beta-lipoproteinemia
Acanthocytes
Uremia
Anemia of Renal Disease
Hereditary Pyropoikilocytosis
G6PD Deficiency
Heart Valve Replacement
Hemolytic Disease of the Newborn
Microangiopathic Hemolytic Anemia (MAHA)
TTP
Severe Burns
Burr Cells(Crenated Cells)
Thorn CellsAcanthocytes
1. 1. Ovalo (green label): normochromic/normocytic ovalocytes. 80%+ are ovalocytes2. H. Ovalo or Review Hered Ovalo: another case. normochromic/normocytic ovalocytes. 80%+ are ovalocytes3. Hered Sphero: Many spherocytes4. Hypo Micro: hypochromic microcytes, few hypochronic ovalocytes,occaisional hypochromic teardrop5: IDA MCV 46 Hgb 3.8: hypochromic microcytes, hypochrmmic ovalocytes, hypochromic teardrops6. B12/Folate 0671264 1993: macrocycytic normochromic RBCs. Well filled with hgb. Few macrocytic ovalocytes, occ hyperseg PMN7: H-J MCV 121: normochromic macrocytes. H-J bociesfew macrocytic target cells8. B12/Folate: Many hpersegmented PMNs Normochromic macrocytes9. NRBC: Many nucleated RBCs, mostly metarubricytes10. ABO HDN: hemolytic disease of the newborn. Earlies stages of nrbc including prorubricyte and rubricyte 11. Mono: increased monocytes12. EOS increased eosinophils13. 75% EOS: increased eosinophils14. Schisto Acantho: Many schistocytes and acanthocytes 15. 09009291992: ?? Mystery slide. What do you see
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http://www.clt.astate.edu/wwilliam/hem_i_erythrocytes_morphology_and__physiology.htm
Copyright ©2005 American Society of Hematology. Copyright restrictions may apply.
Gallagher, P. G. Hematology 2005;2005:13-18
Figure 3. Peripheral blood smears in disorders of the erythrocyte membrane
