Nonselective Catio nChannelsPharmacology, Physiology an dBiophysics

Edited by D . SiemenJ. Hescheler

Foreword ix

List of Contributors x i

Introduction

D. Siemen

Nonselective Cation Channels 3

J. Hescheler and G. Schult zNonselective Cation Channels : Physiological an d

Pharmacological Modulations of Channel Activity 27

Receptor-Activated Nonselective Cation Channels

J. A. DaniStructure, Diversity, and Ionic Permeability of Neuronal an d

Muscle Acetylcholine Receptors 47

P . JonasAMPA-Type Glutamate Receptors - Nonselective Cationi c

Channels Mediating Fast Excitatory Transmission in theCNS 6 1

Mechanically Sensitive Cation Channels

X.-C. Yang and F. SachsMechanically Sensitive, Nonselective Cation Channels 79

M.-C . Wellner and G. IsenbergStretch-Activated Nonselective Cation Channels in Urinar y

Bladder Myocytes : Importance for Pacemaker Potentials andMyogenic Response 9 3

R. Popp, J . Hoyer and H . GögeleinMechanosensitive Nonselective Cation Channels in th e

Antiluminal Membrane of Cerebral Capillaries (Blood-Brai nBarrier) 101

Gap Junction Channels

R. DermietzelThe Gap Junction Channel 10 9

Cyclic Nucleotide-Activated Nonselective Cation Channels

C. J. BarnstableCyclic Nucleotide-Gated Nonselective Cation Channels :

A Multifunctional Gene Family 12 1

F. ZufallCyclic AMP-Gated Cation Channels of Olfactory Recepto r

Neurons 13 5

C. Korbmaeher and C. J. BarnstableRenal Epithelial Cells Show Nonselective Cation Channe l

Activity and Express a Gene Related to the cGMP-Gate dPhotoreceptor Channel 147

D. SchildCiliary Cation Conductances in Olfactory Receptor Cells o f

the Clawed Toad Xenopus laevis 16 5

Nonselective Cation Channels Activated by Intracellular Calciu m

L. D. Partridge and D. SwandullaControl of Cell Function by Neuronal Calcium-Activated

Nonselective (CAN) Cation Channels 17 5

P . Thorn and O. H. PetersenNonselective Cation Channels in Exocrine Gland Cells 18 5

A . Koivisto, E . Dotzler, U . RuJ3, J. Nedergaard and D . SiemenNonselective Cation Channels in Brown and White Fa t

Cells 20 1

R. Popp, H. C. Englert, H. J. Lang and H. GögeleinInhibitors of Nonselective Cation Channels in Cells of the

Blood-Brain Barrier 21 3

C . Siemer and H. GögeleinNonselective Cation Channels in Cells of the Crypt-Base of

Rat Distal Colon 219

Nonselective Cation Channels as Regulatory Components o fCells from Various Tissues

W. Van Driessche, L . Desmedt, P. De Smet and J. SimaelsPoorly Selective Cation Channels in Apical Membranes of

Epithelia 225

G. IsenbergNonselective Cation Channels in Cardiac and

Smooth Muscle Cells 247

R. Inoue and S . ChenPhysiology of Muscarinic Receptor-Operated Nonselectiv e

Cation Channels in Guinea-Pig Ileal Smooth Muscle 26 1

B. Nilius, G . Droogmans, M. Gericke and G. SchwarzNonselective Ion Pathways in Human Endothelial Cells 269

J. Geiger and U. WalterProperties and Regulation of Human Platele t

Cation Channels 28 1

J. J. Gargus, A. M. Frace and F. JungThe Role of a PDGF-Activated Nonselective Cation Channel

in the Proliferative Response 289

T. Kleppisch, A . M. Wobus and J. HeschelerCation Channels in Oocytes and Early States of Development :

A Novel Type of Nonselective Cation Channel Activatedby Adrenaline in a Clonal Mesoderm-Like Cell Line(MES-1) 297

T. Weise rSlowly-Activating Cation Channels in the Vacuolar Membran e

of Plants 305