No. 58 March, 2012tmiya/c-ml/DV_Backnumber...1 Quarterly e-mail newsletter for Ceramics Research...
Transcript of No. 58 March, 2012tmiya/c-ml/DV_Backnumber...1 Quarterly e-mail newsletter for Ceramics Research...
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Quarterly e-mail newsletter for
Ceramics Research Forum in Medicine, Biomimetics, and Biology
THE DIVISION
No. 58 March, 2012
Editor-in-Chief K. Teraoka, National Institute of Advanced Industrial Science and
Technology (AIST)
Associate Editor T. Miyazaki, Kyushu Institute of Technology
T. Kawai, Yamagata University
Editorial Staffs J. Hamagami, Kurume National College of Technology
M. Neo, Kyoto University
T. Sawamura, NGK Spark Plug Co., Ltd. M. Ohgaki, SII Nano Technology Inc. S. Hayakawa, Okayama University C. Ohtsuki, Nagoya University K. Ioku, Tohoku University H. Takeuchi, HOYA Co. K. Ishikawa, Kyushu University N. Tomita, Kyoto University M. Kikuchi, NIMS H. Unuma, Yamagata University S. Nakamura, NIMS
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Contents
1. MESSAGE & OPINION ................................................................................................................................... 3
ïŒå·»é èšïŒ
éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã»ãæããææããããæ°å€ãã®å¯èœæ§ãç§ããææããžïŒæŸæ¬ å°ä¹ïŒ
2. INFORMATION ON RESEARCH & DEVELOPMEMT ............................................................................ 16
ïŒçåŠäœéšèšïŒ
暪äºå€ªå²æ°ïŒã€ã®ãªã¹ã»ããŒãã³ã¬ã 倧åŠïŒ ïŒæšªäº 倪å²ã»å·äº 貎è£ïŒ ïŒåŠäŒåå èšïŒ
The 11th Asian BioCeramics Symposium ïŒèµæ¬ æå¡ïŒ 第ïŒïŒåæ¥æ¬ãã€ãªãããªã¢ã«åŠäŒå€§äŒ ïŒäžæ 梢ïŒ
第 21 åç¡æ©ãªã³ååŠèšè«äŒ åå å ±åèš ïŒå·äº 貎è£ïŒ
3. INTRODUCTION OF RECENT PAPERS ................................................................................................... 24
ïŒè«æ玹ä»ïŒ
4. ANNOUNCEMENT ........................................................................................................................................ 25
ïŒè¡äºæ¡å ïŒ
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1. MESSAGE & OPINION ïŒå·»é èšïŒ
éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ã ãæããææããããæ°å€ãã®å¯èœæ§ãç§ããææããž
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ïŒé£çµ¡å ïŒ[email protected]ïŒ
è¿å¹ŽïŒåœéäŒè°ãåœå åŠäŒã«åå ãããšéå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã«é¢ããç 究ãå¢
å ããŠããã®ãæããŸãïŒããã«ïŒéå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã¯ïŒç§ã®å士課çšæ代ã®
ç 究察象ã§ãã£ãéå±ã€ãªã³åºæº¶ β åãªã³é žäžã«ã«ã·ãŠã ã«ãé¢é£ããŠããããïŒå人
çã«éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã®ç 究ããªãµãŒãããè¯ãæ©äŒãšæã£ãããšïŒããã³ç·š
éå§å¡ã®æ¹ã ã«æè§ã®æ©äŒãé ããããšããïŒæ¬è§£èª¬ãå·çããããšã決æããŸããïŒ
ããããããšç§ã®ãªãµãŒãäžè¶³ãªã©ã§ééããèªèéãããããããããŸãããïŒãã®
éšåã«é¢ããŠã¯ã容赊ããã ããã°ãšæããŸãïŒ
æ¬è§£èª¬ã¯éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã®ç 究ãè¡ã£ãããšããªãç 究è ã«éå±ã€ãªã³åº
溶ã¢ãã¿ã€ãã玹ä»ããïŒãããã¯ç 究ã®ãã£ãããæäŸããç®çã§èšè¿°ããããïŒã¢
ãã¿ã€ãã®åºç€ããèšè¿°ããŠããŸãïŒ
1. éå±ã€ãªã³ãåºæº¶ããã¢ãã¿ã€ã
1.1 ã¢ãã¿ã€ã
ã¢ãã¿ã€ããšã¯M10 (ZO4)6Xã®åºæ¬çµæã®çµæ¶é±ç©ã®ç·ç§°ã§ããïŒãããŸã§ã®ç 究ããïŒè¡š 1 ã«ç€ºãåå çŽ ãåç¬ããã㯠2 çš®é¡ä»¥äžã®çµã¿åãã㧠MïŒZO4ïŒX ã®äœçœ®ã«ããããåºæº¶(眮æ)ããããšãæããã«ãªã£ãŠããïŒã¢ãã¿ã€ãã®äžã§ãã€ãããã·
ã¢ãã¿ã€ã(HAp)ã¯ïŒM=CaïŒZ=PïŒX=OHã® Ca10(PO4)6(OH)2ã§è¡šããããšãã§ããïŒ
Table 1 ã¢ãã¿ã€ããæ§æããå çŽ (ã€ãªã³)
M site
Na+, K+, Rb+, Cs+, Ca2+, Mg2+, Zn2+, Ba2+, Mn2+, Fe2+, Sn2+, Cd2+, Pb2+, Ra2+,
Fe3+, Eu3+, Al3+, Y3+, Bi3+, V3+, Tm3+, Sb3+ Ge4+, Ti4+
ZO4 site SO4
2-, CO32-, HPO4
2-, PO4
3-, AsO43-, VO4
3-, BO33-, CrO4
3- SiO4
4-, GeO44-, BO4
5-
X site OH-, F-, Cl-, Br-, I-, O2-, CO3
2-, H2O
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1.2 çäœææãšããŠã®éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ã
éå±ã€ãªã³åºæº¶HApãçäœææãšããŠç 究察象ã«ãªã£ããã£ãã㯠2ã€ã®çç±ããã§ãããšæããŸãïŒ è¡š 2 ã«ç€ºãããã«çäœéªšäžã«ã¯ Ca2+ã PO4
3-ã€ãªã³ä»¥å€ã«ã骚ã®ç¡æ©çµæãšããŠçé ž
(CO32-)ïŒãããªãŠã (Na+)ããã³ã«ãªãŠã (K+)ã€ãªã³ãªã©ãå«æããŠããïŒãŸãïŒäžèšã®
éå±ã€ãªã³ã®çœ®æ(åºæº¶)ã«ãšããªã HAp çµæ¶æ§é äžã«ã¯ç©ºå(æ¬ é¥)ãååšããïŒåæHAp ãšçäœéªšãšã®å€§ããªéãã¯ïŒãããã®éå±ã€ãªã³ã®å«æãçµæ¶æ§é äžã®ç©ºå(æ¬
é¥)ã®æç¡ã§ããïŒãããã®åœ±é¿ã§åæ HAp ã¯éªšèªå°èœã瀺ããªãã®ã«å¯ŸããŠçäœéªšã¯éªšèªå°èœãæããã ãã§ãªãïŒéªšãªã¢ããªã³ã°çã®çäœåå¿ãåæ»ã«è¡ã£ãŠãããš
èããããŠããïŒããªãã¡ïŒéå±ã€ãªã³ã®åºæº¶ããã³æ¬ é¥æ§é ãå¶åŸ¡ããããšã§çäœ
骚ãšåçãããã¯ãããããåªããææã®äœè£œãå¯èœã§ããããšã 1 ã€ç®ã®çç±ãšããŠèããããŸãïŒ
Table 2 人éã®éªšãæ¯ã«å«ãŸããå çŽ ã®çµæ
Enamel Dentine Bone Ca (wt%) 37.6 40.3 36.6 P (wt%) 18.3 18.6 17.1
CO2 (wt%) 3.0 4.8 4.8 Na (wt%) 0.70 0.1 1.0 K (wt%) 0.05 0.07 0.07
Mg (wt%) 0.2 1.1 0.6 Sr (wt%) 0.03 0.04 0.05 Cl (wt%) 0.4 0.27 0.1 F (wt%) 0.01 0.07 0.1 Zn (ppm) 263 173 39 Ba (ppm) 125 129 Fe(ppm) 118 93 Al (ppm) 86 69 Ag (ppm) 0.6 2 Cr (ppm) 1 2 0.33 Co (ppm) 0.1 1 <0.025 Sb (ppm) 1 0.7 Mn (ppm) 0.6 0.6 0.17 Au (ppm) 0.1 0.07 Br (ppm) 34 114 Si (ppm) 500
Ca/P 1.59 1.67 1.65
2 ã€ç®ã®çç±ãšããŠã¯ïŒéªšããã©ã«æåãå«ãçäœå çŽ (çäœå¿ é å çŽ ïŒçäœå¿ é 埮
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éå çŽ ïŒçäœå¿ é è¶ åŸ®éå çŽ )ãšçäœåå¿ãšã®é¢é£æ§ãããŸããŸãªç 究ã§æããã«ãã
ãŠãããããšèããããŸãïŒè¿å¹Žã§ã¯è¡š 2ã®æ¯ã骚ããã«äœã®åéšäœã«ããã ppmãªãŒããŒã®çäœå çŽ æåã®åæãå¯èœãšãªãïŒçäœå¿ é 埮éå çŽ ãè¶ åŸ®éå çŽ ãšçäœå
å¿ã«é¢ããç 究ææã«ã€ããŠãïŒçäœåå¿ã«é¢ãã枬å®æ¹æ³ããã³æž¬å®æ©åšã®ç²ŸåºŠå
äžãšãšãã«å¢å åŸåã«ããïŒè¡š 3 ã«ãããã®ç 究ã§æããã«ãªã£ãåå çŽ ã®éªšåœ¢æãªã©ãäžå¿ãšããçäœåå¿ãžã®åœ±é¿ãç°¡åã«ãŸãšããïŒ ããã«è¿å¹Žã§ã¯çäœå ã«ååšããªãïŒãããŠé«ãæ¯æ§ããããšèªèãããŠãããªã
ãŠã ã€ãªã³(Li+ã€ãªã³)ã«ã€ããŠãïŒéªšåœ¢æãä¿é²ãããšã®å ±åããã 1)-3)ïŒãŸãïŒåã
ãçäœå ã«ã¯ååšããªãããªãžã ãã¬ããªããŠã ã€ãªã³åºæº¶HApã®çäœå¿çšãç®çãšããè«æãååšãã 4)ïŒ
Table 3 çäœå¿ é å çŽ ãšéªšåœ¢æã«ãããäœçš
å çŽ äœçš ãããªãŠã (Na) 骚代è¬ãååžåããã»ã¹ïŒçŽ°èæ¥çã«é¢äž ã«ãªãŠã (K) ⢠çååŠåå¿ã«ãããŠå€ãã®æ©èœã«é¢äž
⢠骚çææã®ã¢ãã¿ã€ãã®æ žåœ¢æã«é¢äž ã ã° ã 㷠㊠ã (Mg)
⢠骚èœçŽ°èãç ŽéªšçŽ°èã掻æ§åãïŒéªšæé·(骚圢æ)ãä¿é² ⢠HApã®æ žåœ¢æãæ žæé·(åç³ç°å)ãä¿é² ⢠骚匷床ã骚å¯åºŠã®å¢å äœçšâæ¬ ä¹ã§éªšç²é¬çã®ãªã¹ã¯å¢å
äºé (Zn) ⢠DNAã RNAã®è€è£œïŒã¿ã³ãã¯è³ªåæã«é¢äžããå€ãã®é µçŽ å ±åå å
â¢ ç ŽéªšçŽ°èã®ååãæå¶ãããïŒéªšèœçŽ°èã掻æ§åïŒ â¢ éªšæ Œã®åœ¢æãçºéã«å¿ èŠãªå çŽ âæ¬ ä¹ãããšéªšå¯åºŠãäœäž(骚ç²é¬çã®ãªã¹ã¯ãå¢å )
ãã³ã¬ã³ (Mn) ⢠骚ãªã¢ããªã³ã°ã®èª¿æŽã«åœ±é¿ãäžãã â¢ æ¬ ä¹ãããšææ©ãããªãã¯ã¹ã®åæäœäž ⢠è»éªšã®éªšåœ¢æãæå¶ â¢ éªšç²é¬çæ£è ã®éªšéæžå°ãäºé²ãããµããªã¡ã³ããšããŠäœ¿çš
ã¹ããã³ããŠã (Sr)
â¢ ç ŽéªšçŽ°èã®æŽ»æ§ãååãäœäžããïŒå骚èœçŽ°èã®è€è£œïŒéªšèœçŽ°èã®ååãä¿é²â骚圢æä¿é²
⢠骚ååžåãæå¶â骚ç²é¬çã®æ²»çã«ãããŠäœæ¿åºŠã®æçšã§å¹æ
⢠骚圢æãµã€ãã骚å¯åºŠã®å¢å ããçŽ (F) ⢠è«æ¯ãäºé²
⢠骚现èã®å¢æ®ãååãä¿é² å¡©çŽ (Cl) 骚ååžåããã»ã¹ã«ãããŠç ŽéªšçŽ°èã掻æ§åãããé žæ§
ç°å¢äžã 骚衚é¢ã«çºçŸ ã±ã€çŽ (Si) ⢠骚çæã«é¢äžãã代è¬æ©æ§ã«äœçš
⢠骚现èãçµå现èã®çºçŸã«é¢äžãã代è¬ããã»ã¹ã«é¢äž
â¢ æ¬ ä¹ã«ãã骚èœçŽ°èã®å¢æ®ãæ©èœãäœäž â骚éæžå°ã骚ç²é¬çãªã©ã®ãªã¹ã¯ãå¢å
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äžèšã® 1 ã€ç®ã®çç±ã«å ããŠãã® 2 ã€ç®ã®éå±ã€ãªã³ã®çäœå ã§ã®è©³çŽ°ãªäœçšæ©æ§
ãæããã«ãªã£ãŠããããšãè¿å¹Žã®éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã®ç 究ãçãã«ãªã£ãŠ
ããçç±ã§ãããšæããŸãïŒ
2. éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã«ãããéå±ã€ãªã³ã®åºæº¶åœ¢æ
2.1 HApã®çµæ¶æ§é
ã¢ãã¿ã€ã㯠Bravaisæ Œåã«åºã¥ãåé¡ã§ã¯å æ¹æ¶ç³» P63/mã«å±ããŸããïŒååŠéè«
çµæã® HApã¯åææ¶ç³» P21/bã§ããïŒãããïŒå®éã®çäœéªšäžã® HApã«ã¯äžèšã«ç€ºããããã«åŸ®éã®éå±å çŽ ã空å(æ Œåæ¬ é¥)ãå«ãããå æ¹æ¶ç³»ã«å±ããïŒHAp ã®åäœæ Œåã¯å¹³è¡å é¢äœã§ãã®çšã¯ 120°㮠2 ã€ã®å¹³è¡ãªè»žãšãã®è»žã«äº€ãã軞ã«ãã£ãŠæ§
æãããïŒçµæ¶æ§é äžã® Ca2+ã€ãªã³ã¯ç°ãªã 2ã€ã®äœçœ®ã«ååšããïŒäžã€ã¯ columnar Ca [Ca(1)]ãšåŒã°ãïŒ9ã€ã®é žçŽ ååã«å²ãŸããå€é¢äœã圢æãïŒç çªã®ãããªæ§é ãããŠããŠç§»åããããïŒããäžã€ã¯ïŒscrew Ca [Ca(2)]ãšåŒã°ãïŒåäœæ Œåã®åé ç¹ã«ã«ã«
ã·ãŠã ãååšããæ§é ã«ãªã£ãŠããïŒ6 åã® PO43-ã€ãªã³ã¯äžå¿ã®ãªã³ã€ãªã³ãšãã®åš
ãã® 4 åã®é žçŽ ããæãåé¢äœã圢æãïŒãŸã c 軞äžã«äœçœ®ãã 2 ã€ã® OH-ã€ãªã³ã¯
åãå¹³é¢å äžã§ 3ã€ã® Ca2+ã€ãªã³ã«å²ãŸããŠããïŒ
2.2 ã¢ãã¿ã€ãæ§é äžã«ãããéå±ã€ãªã³ã®åºæº¶åœ¢æ
䟡æ°ã®ç°ãªãéœã€ãªã³ãŸãã¯é°ã€ãªã³ãåºæº¶ããåçš®éå±ã€ãªã³åºæº¶HApã®çµæ¶æ§
é ã«ã€ããŠïŒçäœææãšããŠã®å¿çšãæ€èšãããŠããéå±ã€ãªã³ãäžå¿ã«è¿°ã¹ãïŒãŸ
ãïŒããããã®éå±ã€ãªã³åºæº¶ã¢ãã¿ã€ãã®è©³çŽ°ã«ã€ããŠã¯ïŒåé ç®ã«ç€ºããæç®ã
äžæ§ååæã Xç·åæãªã©ã«ããçµæ¶æ§é 解æãå ±åããè«æãªã©ãåèã«ããŠãã
ã ããããšæããŸãïŒ
(1) Caãµã€ããžã®åºæº¶
2.1ã«ç€ºããããã«ã¢ãã¿ã€ãæ§é ã«ã¯ Ca(1)ããã³ Ca(2)ãµã€ããååšãããïŒã©ã¡ãã«åºæº¶ãããã¯åºæº¶ããéœã€ãªã³ã®ã€ãªã³ååŸãé»æ°é°æ§åºŠã«å¯æ¥ã«é¢é£ãã 5)ïŒ
ããªãã¡ïŒ(Ca ã€ãªã³ããã)ã€ãªã³ååŸããã³é»æ°é°æ§åºŠã倧ããéœã€ãªã³ã¯ Ca(2)
ãµã€ãã«åªå çã«åºæº¶ãã 5)ïŒãŸãïŒã€ãªã³äº€æåå¿ã§ã¯ïŒã€ãªã³ååŸã Ca2+ã€ãªã³ã«
æ¯ã¹ãŠå°ããéå±ã€ãªã³ã¯ Ca(1)ãµã€ãã«ïŒå€§ããªã€ãªã³ã¯ Ca(2)ã«ïŒããããååžããåŸåããã 6)ïŒ
ãããïŒåãéå±ã€ãªã³ã§ãåªå ããŠåºæº¶ãã Caãµã€ããéãããšãå€ãèŠåããããïŒäŸãã°ïŒçµæ¶æ§é ã®å€åã«ãšããªãå€åããçµæ¶æ§é ã®åäœæ Œåã«ãããæ Œå
å®æ°ã«ã€ã㊠Zn2+ã€ãªã³åºæº¶ HApã®å ŽåïŒDiazã㯠Zn2+ã€ãªã³åºæº¶éã®å¢å ã«ãšããª
ã aããã³ c軞ã®æ Œåå®æ°ãšãã«æžå°ãããšå ±åããŠãããïŒMiyajiã㯠a軞ã Zn2+
ã€ãªã³åºæº¶é 5mol%ãŸã§æžå°åŸïŒãã以äžã®åºæº¶éã§å¢å ãïŒc 軞ã¯åºæº¶éã®å¢å ã«
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ãšããªãæžå°ããããšãå ±åããŠãã 7)-9)ïŒãããã®éãã«ã€ã㊠Li ãã¯éå±ã€ãªã³
åºæº¶ HApã®åææ¹æ³ãåææ¡ä»¶ã«äŸåãããšå ±åããŠããã 9)ïŒãããå®èšŒããå ±å
ã¯ãªãïŒHApã«ãããéœã€ãªã³ã®åºæº¶åœ¢æ ãçµæ¶æ§é ãè«æãªã©ã§èª¿æ»ããå Žåã¯ïŒæž¬å®è©Šæã®åææ¹æ³ãåææ¡ä»¶ïŒåæåºæº¶ããã€ãªã³(CO3
2-ã F-ã€ãªã³)ã®æç¡ãåºæº¶
éãªã©ã«æ³šæããå¿ èŠãããïŒ
a) äžäŸ¡éå±ã€ãªã³ (ãããªãŠã ã€ãªã³ïŒã«ãªãŠã ã€ãªã³ïŒéã€ãªã³)
Na+ã€ãªã³ã¯ Ca(1)ããã³ Ca(2)ãµã€ãã®äž¡æ¹ã«åºæº¶ãããïŒNa+ã€ãªã³åºæº¶éãé«
ãå Žå(90%以äž)㯠Ca(2)ã«åªå çã«åºæº¶ãã 10)ïŒãŸãïŒäžäŸ¡éå±ã€ãªã³ãåºæº¶ãã
å Žåã«ã¯ïŒé»è·è£å(䟡æ°ã®ç°ãªãã€ãªã³ãåºæº¶ããå Žåã«çµæ¶æ§é äžã®é»è·ãã©ã³
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ãã«ãªã£ãŠãããã°ãšé¡ã£ãŠããŸãïŒ Reference
1) R. T. Moon et al., Science, 296, 1644â1646 (2002). 2) V. Krishnan et al., J. Clin. Investigation, 116, 1202â1209 (2006). 3) P. C. Lacroix et al., Proceedings of the National Academy of Sciences of the United States
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ã§ã³ã®åªç§çºè¡šè³ã«ã¯ãäžæºå€§åŠã®æµ éæ䜳éãããå倧åŠã®éŠ¬å Žç¥äžéãããæ±äº¬å»ç§æ¯ç§å€§åŠ/åèå·¥æ¥å€§åŠã®æž¡äŒåå žãããã®ã°ã«ãŒããéžã°ããã 次åïŒç¬¬ 22åïŒã®èšè«äŒã¯ãå¹³æ 24幎 9ææ«ã«ç¥æžè¬ç§å€§åŠã®äžå±±å°éå çã»ç¥æžå€§åŠã®æçžè£ä¹å çã®ãäžè©±ã®ããšãç¥æžå€§åŠå ç²ãã£ã³ãã¹ã§éå¬ãããæšã®ã¢ããŠã³ã¹ããã£ããçè ã®åºèº«å€§åŠã§ã®éå¬ãšããããšããããä»ãã楜ãã¿ã§ãããšãšãã«ãããå å®ããç 究çºè¡šãã§ããããéé²ãããã
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3. INTRODUCTION OF RECENT PAPERS ïŒè«æ玹ä»ïŒ
Human osteoblas response to pulsed laser deposited calcium phosphate coatingsïŒPLDã§æèããããªã³é žã«ã«ã·ãŠã èã«å¯Ÿãã人骚èœçŽ°èã®åå¿ïŒ A. Bigi et al., Biomaterials, 26, 2381-2389 (2005)
ãã¿ã³äžã« Pulsed Laser Deposition (PLD)ã§åœ¢æããã«ãªã³é žã«ã«ã·ãŠã èã«å¯Ÿãã人骚èœçŽ°èã®åå¿ã«é¢ããç¥èŠãæäŸããè«æãèè ã㯠PLDãåŸæãšããŠããããã®æè¡ãé§äœ¿ããããšã«ããèã®çµæãå¶åŸ¡ããŠããã該æè¡ã«ããèè ãã¯OCPèãšMn 眮æçé žã¢ãã¿ã€ãèãçšæããŠãããã€ã³ããããæšæž¬ããã«ãèè ãã¯çé žã¢ãã¿ã€ãMn眮æã§ææã®çŽ°èæ¥çã®ããããïŒligand-binding affinityïŒåäžãç®è«ãã§ããæ§ã«æãããä»å· The DVã®ããŒããç §ããåããããšãç¹ã«Mn眮æçé žã¢ãã¿ã€ãèã«é¢ããçµæãããã¢ãã¿ã€ãã®äœãã眮æããæ矩çãæ±²ã¿åããããšããã§ãã£ãããMn眮æçé žã¢ãã¿ã€ãèã«ã¯OCPãšã»ãŒåæ§ã®çµæãèŠãã«ãšã©ãŸã£ãããããããããæ¬ç 究ãšåæ§ã®æ€èšãã»ã«ã©ã€ã³ã§è¡ã£ããããªããšãããããã§ããé«ãæææåæ§ãæåŸ ããŠäººç±æ¥éªšèœçŽ°èã«ããèè©äŸ¡ã«ææŠããã®ãããããªãããªãã»ã©ãèè ãã¯ãçäœææè©äŸ¡ã«ã¯äººç±æ¥ã®çŽ°èãçšããã¹ããšã®æ 床ããšã£ãŠãããïŒæ責 å¯ºå²¡ïŒ Revisiting silicate substituted hydroxyapatite by solid-stateïŒåºäœNMRãçšããŠã±ã€çŽ 眮ææ°Žé žã¢ãã¿ã€ãã«ç«ã¡æ»ãïŒ
G. Gasqueres, C. Bonhomme, J. Maquet, F. Babonneau, S. Hayakawa, T. Kanaya and A. Osaka,
Magn. Reson. Chem., 46, 342â346 (2008)
ãã®ç 究ã§ã¯ïŒæ²æ®¿æ³ã«ããäœè£œããã±ã€çŽ 眮æã¢ãã¿ã€ãã®åŸ®çŽ°æ§é ãåºäœ NMR
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ããŠã¯ïŒãã®ããäžéšã SiO44-ã€ãªã³ã«å¯Ÿå¿ãã Q0ç¶æ ãšããŠæ°Žé žã¢ãã¿ã€ãæ Œåã®å
éšã«ååšãïŒå€§åã¯ã·ãªã«ã²ã«ã«å¯Ÿå¿ããç¶æ ã§æ Œåã®å€ã«ååšããŠããããšãåãã£
ããåºäœ NMR ã¯ïŒçš®ã ã®ã±ã€çŽ å«æææã®æ§é 解æã«æçšãªããŒã«ãšãªãããããã
äžåºŠç«ã¡æ»ããšããæå³ã§ã¿ã€ãã«ã«"Revisiting"ã䜿ãããŠãããšããã«æ°é®®ããæã
ããïŒæ責 å®®åŽïŒ
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4. ANNOUNCEMENT
ïŒè¡äºæ¡å ïŒ (1) The 9th World Biomaterials Congress ãæ¥æã 2012幎 6æ 1~5æ¥ ãå Žæã äžåœïŒæéœ ãããŒã ããŒãžã http://www.wbc2012.com (2) IUMRS-ICA2012 ãæ¥æã 2012幎 8æ 26~31æ¥ ãå Žæã éåœïŒéå±± ãããŒã ããŒãžã http://www.iumrs-ica2012.org/ (3) æ¥æ¬ã»ã©ããã¯ã¹åäŒç¬¬ 24åç§å£ã·ã³ããžãŠã ãæ¥æã 2012幎 9æ 19æ¥~21æ¥ïŒ ãå Žæã åå€å±å€§åŠ ãããŒã ããŒãžã http://www.ceramic.or.jp/ig-syuki/25th/ (4) 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine (Bioceramics 24) ãæ¥æã 2012幎 10æ 21~24æ¥ ãå Žæã ä¹å·å€§åŠ ãããŒã ããŒãžã http://www.bioceramics24.dent.kyushu-u.ac.jp/index.php/24/24 (5) 12th Asian BioCeramics Symposium (ABC2012) ãæ¥æã 2012幎 11æ 18~21æ¥ ãå Žæã å°æ¹ŸïŒåœç«æå倧åŠïŒå°ååžïŒ ãããŒã ããŒãžã http://conf.ncku.edu.tw/abc2012/ (6) 第 24å éæ¥ã»ã©ããã¯ã¹ã»ãã㌠ãæ¥æã 2012幎 11æ 21~24æ¥ ãå Žæã éåœïŒå€§é± ãããŒã ããŒãžã http://www.kj-ceramics29.org/index.php (7) æ¥æ¬ãã€ãªãããªã¢ã«åŠäŒã·ã³ããžãŠã 2012 ãæ¥æã 2012幎 11æ 26ïœ27æ¥ ãå Žæã ä»å°åœéã»ã³ã¿ãŒ ãããŒã ããŒãžã http://kokuhoken.net/jsbm/event/meet_34.html
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