NIMH/DARResearch Priorities and Funding Opportunities

Christopher Gordon, Ph.D.

Branch Chief,

NIMH Division of AIDS Research

Johns Hopkins CFAR

November 5, 2014

Toward Combination HIV Prevention

Coates 2008 Lancet

Selected NIMH HIV Research Priorities

Targets Funding Opps

Adherence to ART and PrEP PA-14-126

Steps in HIV care continuum PA-14-132

Approaches

Social determinants and structural interventions PA-14-133

Addressing stigma and health PA-13-248

Mental health and syndemic factors Stay tuned

Basic behavioral and social science PA-14-127

Implementation science PA-14-131

Populations

Key populations evidencing disparities Throughout

Adherence to ART and PrEPNIMH PA-14-126

Improve adherence monitoring

Novel approaches/technologies for:-- Timely detection of non-adherence -- Triaging those in need to intervention-- Empower patients via real-time feedback loops

Test novel interventions to improve PrEP and ART outcomes

-- Technology-assisted approaches-- Targeting syndemic factors (e.g. depression)-- Structural/social determinants approaches

(e.g. microeconomic, food security, anti-stigma)

WisepillHaberer 2010 AIDS Behav

CBT-ADSafren 2009 Health Psy

NIMH Contact:Dr. Michael Stirratt

Improving the HIV Care ContinuumNIMH PA-14-130

Study pathways through the care continuum

-- longitudinal studies-- disparities populations

Identify determinants and evaluate approaches to strengthen…

-- HIV testing (inc. home-testing)-- Linkage to care-- Retention in care

Requires research teams to be academic & DoH partnerships.

NIMH Contact:Dr. Christopher Gordon

Wel-Tel Retain InterventionVan der Kop + Lester 2013 BMJ Open

Determinants of Care EngagementMugavero 2011 CID

Social Determinants/Structural Interventions NIMH PA-14-133

Target areas include… -- Stigma and discrimination -- Social violence-- Economic factors -- Legal factors

Emphasis on… -- mechanisms by which social determinants shape prevention and treatment

-- informing structural interventions to ameliorate these processes and improve outcomes

Sociocultural

Community

Interpersonal

Individual

NIMH Contact:Dr. Cynthia Grossman

Socio-Ecologic PerspectivesFood Insecurity / Income Generation

Weiser 2011 Am J Clin NutrTsai 2013 PLoS Med

Implementation Science and Translational Research NIMH PA-14-129/131

Key Highlights

Program Officer: Christopher Gordon

Mechanism(s): R01 (131) R21 (129)

Objectives and Scope

Maximize the public health impact of

available interventions

- Deliver interventions efficiently and effectively- Transfer from one setting/population others- Better-informed public health decisions

Projects include, but are not limited to:

- Dissemination Research- Research Syntheses- Cost-effectiveness- Health Systems- Comparative Effectiveness- Policy Analysis

NIMH Division of AIDS Research –

Contact Information

Susannah Allison, Ph.D. allisonsu@mail.nih.gov

Pim Brouwers Ph.D. ebrouwer@mail.nih.gov

Deborah Colosi, Ph.D. Deborah.colosi@nih.gov

Rebecca DelCarmen-Wiggins, Ph.D. rdelcarm@mail.nih.gov

Christopher Gordon, Ph.D. cgordon1@mail.nih.gov

Cynthia Grossman, Ph.D. grossmanc@mail.nih.gov

Jeymohan Joseph, Ph.D. jjeymoha@mail.nih.gov

Willo Pequegnat, Ph.D. wpequegn@mail.nih.gov

Dianne Rausch, Ph.D. drausch@mail.nih.gov

Michael Stirratt, Ph.D. stirrattm@mail.nih.gov

David Stoff, Ph.D. dstoff@mail.nih.gov

5601 Fishers Lane

Rockville, MD 20852

THANKS!