NIH CHEMISTRY Search Compounds DATABASE PUBCHEM … · 19/09/2016 MANCOZEB | C8H12MnN4S8Zn PubChem...

19/09/2016 MANCOZEB | C8H12MnN4S8Zn PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/3034368 1/67

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O P E NCHEMISTRYD A T A B A S E

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PUBCHEM COMPOUND MANCOZEB

MANCOZEB Cite this Record

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Literature

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PubChem CID: 3034368

Chemical Names:MANCOZEB; Dithane; 8018017; Carmazine; Kascade;

Mancomix; More...

Molecular Formula: C H MnN S Zn

Molecular Weight: 541.045725 g/molInChI Key: CHNQZRKUZPNOOHUHFFFAOYSAJSafety Summary: Laboratory Chemical Safety Summary (LCSS)Modify Date: 20160917Create Date: 20050808

8 12 4 8

Compound Summary for CID 3034368

https://www.nih.gov/https://www.nlm.nih.gov/https://www.ncbi.nlm.nih.gov/https://pubchem.ncbi.nlm.nih.gov/https://pubchem.ncbi.nlm.nih.gov/https://www.ncbi.nlm.nih.gov/pccompoundhttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C8H12MnN4S8Zn&sort=mw&sort_dir=asc



Contents1 2D Structure

2 3D Conformer

3 Names and Identifiers

4 Chemical and Physical Properties

5 Related Records

6 Chemical Vendors

7 Agrochemical Information

8 Pharmacology and Biochemistry

9 Use and Manufacturing

10 Identification

11 Safety and Hazards

12 Toxicity

13 Literature

14 Biological Test Results

15 Classification

16 Information Sources



from PubChem

1 2D Structure

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from PubChem

2 3D Conformer

3D Conformer of Parent Compound ETHYLENEBISDITHIOCARBAMIC ACID (CID 3000605)

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https://pubchem.ncbi.nlm.nih.gov/compound/3000605



3 Names and Identifiers

3.1 Computed Descriptors

zinc;manganese(2+);N[2(sulfidocarbothioylamino)ethyl]carbamodithioate

from PubChem

3.1.1 IUPAC Name

InChI=1S/2C4H8N2S4.Mn.Zn/c2*73(8)51264(9)10;;/h2*12H2,(H2,5,7,8)(H2,6,9,10);;/q;;2*+2/p4

from PubChem

3.1.2 InChI

CHNQZRKUZPNOOHUHFFFAOYSAJ

from PubChem

3.1.3 InChI Key

C(CNC(=S)[S])NC(=S)[S].C(CNC(=S)[S])NC(=S)[S].[Mn+2].[Zn+2]

from PubChem

3.1.4 Canonical SMILES

C H MnN S Zn

from PubChem

3.2 Molecular Formula

8 12 4 8

3.3 Other Identifiers

8018017

from ILOICSC

3.3.1 CAS

6169955

from ECHA

3.3.2 EC Number

0754

from ILOICSC

3.3.3 ICSC Number

https://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C8H12MnN4S8Zn&sort=mw&sort_dir=aschttp://www.ilo.org/dyn/icsc/showcard.display?p_card_id=0754



ZB3200000

from ILOICSC

3.3.4 RTECS Number

2210

from ILOICSC

3.3.5 UN Number

Title Mancozeb

Description chemical compound

from Wikipedia

3.3.6 Wikipedia

3.4 Synonyms

1. ethylenebisdithiocarbamate manganesezinc2. mancozeb

from MeSH

3.4.1 MeSH Synonyms

1. MANCOZEB2. Dithane3. 80180174. Carmazine5. Kascade6. Mancomix7. Mancozi8. Manoseb9. Milcozebe10. Nemispor

11. Penncozeb12. Vondozeb13. Zimanat14. Zimaneb15. Manzeb16. Marzin17. Fore18. Liro manzeb19. Manebzinc20. ZimanDithane

21. Karamate N22. Greendaisen M23. Tritogol MZ24. Indofil M 4525. Manzate 20026. Novozir MN 8027. Agrox 16D28. Othane M 4529. UNIIR0HY55EB9E30. Zinc manganese ethylenebisdithiocarbamate

31. F 296632. Karamate33. Mancofol34. Mancozebe35. Mancozin36. Marzidan37. Sandozebe38. Manzin39. Dithane ultra40. Vondozeb plus

41424344454647484950

from PubChem

3.4.2 DepositorSupplied Synonyms

http://www.cdc.gov/niosh-rtecs/ZB30D400.htmlhttps://en.wikipedia.org/wiki/Mancozebhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22MANCOZEB%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Dithane%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%228018-01-7%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Carmazine%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Kascade%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancomix%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancozi%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manoseb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Milcozebe%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Nemispor%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Penncozeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Vondozeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Zimanat%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Zimaneb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manzeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Marzin%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Fore%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Liro%20manzeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Maneb-zinc%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Ziman-Dithane%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Karamate%20N%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Green-daisen%20M%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Tritogol%20MZ%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Indofil%20M%2045%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manzate%20200%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Novozir%20MN%2080%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Agrox%2016D%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Othane%20M%2045%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22UNII-R0HY55EB9E%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Zinc%20manganese%20ethylenebisdithiocarbamate%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22F%202966%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Karamate%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancofol%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancozebe%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancozin%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Marzidan%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Sandozebe%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manzin%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Dithane%20ultra%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Vondozeb%20plus%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5D



4 Chemical and Physical Properties

Molecular Weight 541.045725 g/mol

Hydrogen Bond Donor Count 4

Hydrogen Bond Acceptor Count 8

Rotatable Bond Count 6

Exact Mass 538.749952 g/mol

Monoisotopic Mass 538.749952 g/mol

Topological Polar Surface Area 181 A^2

Heavy Atom Count 22

Formal Charge 0

Complexity 108

Isotope Atom Count 0

Defined Atom Stereocenter Count 0

Undefined Atom Stereocenter Count 0

Defined Bond Stereocenter Count 0

Undefined Bond Stereocenter Count 0

CovalentlyBonded Unit Count 4

from PubChem

4.1 Computed Properties

4.2 Experimental Properties

GREYISHYELLOW POWDER.

from ILOICSC

4.2.1 Physical Description

Greyishyellow freeflowing powderTomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council

from HSDB

Blue to green powdered solidMeister, R.T., Sine, C; Crop Protection Handbook Volume 94. Meister Media Worldwide, Willoughby, OH 2008, p. D 279

from HSDB

4.2.2 Color

Practically odorlessMeister, R.T., Sine, C; Crop Protection Handbook Volume 94. Meister Media Worldwide, Willoughby, OH 2008, p. D 279

4.2.3 Odor



from HSDB

Decomposes at 172 deg CTomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council

from HSDB

4.2.4 Melting Point

137.8 deg C (tag open cup)Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.635

from HSDB

138°C o.c.

from ILOICSC

4.2.5 Flash Point

Insoluble in waterO'Neil, M.J. (ed.). The Merck Index An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co.,Inc., 2006., p. 988

from HSDB

In water, 6.2 ppm, pH 7.5, 25 deg CTomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council

from HSDB

Insoluble in most organic solvents; dissolves in solutions of powerful chelating agents but cannot be recovered fromthem

Tomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council

from HSDB

in water: none

from ILOICSC

4.2.6 Solubility

1.92Tomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council

from HSDB

(water = 1): 1.92

from ILOICSC

4.2.7 Density

1.32X1010 mm Hg at 25 deg C

4.2.8 Vapor Pressure

https://pubchem.ncbi.nlm.nih.gov/compound/water



US Dept Agric; The Pesticide Properties Database. Available from on Mancozeb (8018017) as of Dec 17, 2009:http://www.ars.usda.gov/Services/docs.htm?docid=14199

from HSDB

Vapour pressureat 20°C: negligible

from ILOICSC

log Kow = 1.33US Dept Agric; The Pesticide Properties Database. Mancozeb (8018017). Available from, as of Dec 17, 2009:http://www.ars.usda.gov/Services/docs.htm?docid=14199

from HSDB

1.33

from ILOICSC

4.2.9 LogP

Stable under normal, dry storage conditions. Slowly decomposed by heat and moisture.Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.635

from HSDB

4.2.10 Stability

The substance decomposes slowly on heating or on contact with acids and moisture producing toxic and irritating fumesincluding sulfur oxides, nitrogen oxides, zinc oxide, manganese oxide, hydrogen sulfide, carbon sulfide, ethylene thiuramsulfide, ethylene bisisothiocyanate, ethylene urea and 2mercaptoimidazoline.

International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html

from HSDB

4.2.11 Decomposition

No corrosive propertiesMeister, R.T., Sine, C; Crop Protection Handbook Volume 94. Meister Media Worldwide, Willoughby, OH 2008, p. D 279

from HSDB

4.2.12 Corrosivity

http://www.ars.usda.gov/Services/docs.htm?docid=14199http://www.ars.usda.gov/Services/docs.htm?docid=14199https://pubchem.ncbi.nlm.nih.gov/compound/zinc%20oxidehttps://pubchem.ncbi.nlm.nih.gov/compound/hydrogen%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethylenethiuram%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethyleneureahttps://pubchem.ncbi.nlm.nih.gov/compound/2-mercaptoimidazolinehttp://www.inchem.org/pages/icsc.html



5 Related Records

Parent Compound ETHYLENEBISDITHIOCARBAMIC ACID (CID 3000605)

from PubChem

5.1 Parent Compound

Same Parent, Connectivity 82 records

Same Parent, Exact 80 records

Mixtures, Components, andNeutralized Forms 3 records

Similar Compounds 10 records

from PubChem

5.2 Related Compounds

5.3 Substances

Same 26 records

from PubChem

5.3.1 Related Substances

Chemical Vendors (7)

Curation Efforts (5)

Governmental Organizations (6)

Journal Publishers (1)

NIH Initiatives (4)

Research and Development (7)

Subscription Services (5)

Legacy Depositors (1)

from PubChem

5.3.2 Substances by Category

5.4 Entrez Crosslinks

Download

https://pubchem.ncbi.nlm.nih.gov/compound/3000605https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound_parent_connectivity_pulldown&from_uid=3034368https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound_parent_pulldown&from_uid=3034368https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound_mixture&from_uid=3034368https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound&from_uid=3034368https://www.ncbi.nlm.nih.gov/pcsubstance/?term=3034368[StandardizedCID]



PubMed 69 records

Taxonomy 5 records

OMIM 9 records

Gene 65 records

from PubChem

https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_pubmed&db=pccompound&cmd=Link&from_uid=3034368https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_taxonomy&db=pccompound&cmd=Link&from_uid=3034368https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_omim&db=pccompound&cmd=Link&from_uid=3034368https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_gene&db=pccompound&cmd=Link&from_uid=3034368



Vendor/Supplier Purchasable Chemical PubChem SID

3B_SCI_CORP

DR003213 253680599

LP113097 254720550

OR192026 254410079

OR211332 254148826

ChemFrog 888478104 125501243

Finetech Industry Limited FT0628143 164811972

ChemTik CTK8G0735 163135635

from PubChem

6 Chemical Vendors Refine/Analyze Download

http://www.3bsccorp.com/http://3bsccorp.com/drug-like-molecules-and-api/DR003213https://pubchem.ncbi.nlm.nih.gov/substance/253680599http://3bsccorp.com/lipids/LP113097https://pubchem.ncbi.nlm.nih.gov/substance/254720550http://3bsccorp.com/organic-chemicals/OR192026https://pubchem.ncbi.nlm.nih.gov/substance/254410079http://3bsccorp.com/organic-chemicals/OR211332https://pubchem.ncbi.nlm.nih.gov/substance/254148826http://www.chemfrog.com/http://www.chemfrog.com/getPSupply/VHGMNV/https://pubchem.ncbi.nlm.nih.gov/substance/125501243http://www.finetechnology-ind.com/http://www.finetechnology-ind.com/product_detail.shtml?catalogNo=FT-0628143https://pubchem.ncbi.nlm.nih.gov/substance/164811972http://www.chemtik.com/http://www.chemtik.com/pro_result/860726/https://pubchem.ncbi.nlm.nih.gov/substance/163135635



7 Agrochemical Information

Fungicide

from EU Pesticides Database, EPA Office of Pesticide Programs

7.1 Agrochemical Category

EU Pesticides Data: 1 of 1

Substance Mancozeb

Status Approved on 01/07/2006 Expired on 31/01/2018

ADI 0.05 mg/kg bw/day

ARfD 0.6 mg/kg bw

AOEL 0.035 mg/kg bw/day

from EU Pesticides Database

7.2 EU Pesticides Data



8 Pharmacology and Biochemistry

Fungicides, IndustrialChemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, inswimming pools, etc. See a list of PubChem compounds matching this category.

from MeSH

8.1 MeSH Pharmacological Classification

Ethylenethiourea is a decomposition product and metabolite of the ethylenebis(dithiocarbamate) group of fungicides.Following administration of single oral doses of (14)C ethylenethiourea to pregnant rats, maternal blood maintainedpeak radioactivity for 2 hr, and the radioactivity was dispersed uniformly between the RBC and plasma. The level ofradioactivity was distributed equally among several maternal tissues but was present in lower amounts in embryos. 24 hrafter treatment all tissues examined, except blood, were relatively clear of radioactivity, and 72.8% of the totalradioactivity given had been excreted in the urine. Elution patterns of metabolites for Sephadex separation suggestedthat ethylenethiourea was degraded very little. /Ethylenebis(dithiocarbamate) group of fungicides/ Abstract: PubMed

Ruddick JA et al; Teratology 13 (1): 35 (1976)

from HSDB

Mancozeb appears to be rapidly absorbed from the gastrointestinal tract, distributed to target organs and excretedalmost totally by 96 hr.

Purdue University; National Pesticide Information Retrieval System, Mancozeb Fact Sheet No. 125 (1987)

from HSDB

Rats dosed via a stomach tube with 20 mg (14)Cmancozeb per day for 7 days (equivalent to approx 100 mg/kg bodyweight) were killed one day after the last dose and the radioactivity in excreta and organs was measured. In the feces,urine, organs and tissues, and carcass, 71%, 16%, 0.31%, and 0.96% of the total radioactivity was detected,respectively. Specifically, the liver contained 0.19%, the kidneys, 0.076%, the thyroid gland, 0.003%, and all otherorgans,



In oral rat metabolism studies conducted with radiolabeled parent /ethylenebisdithiocarbamate compounds (EBDC)/,there was an average 7.5% in vivo conversion of the EBDC to ETU, on a weighttoweight basis.

USEPA/Office of Pesticide Programs; Mancozeb: Human Health Risk Assessment p.29. Identification No. EPAHQOPP200501760002 (June 2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home

from HSDB

In plants, the principal metabolite is ethylenethiourea, which undergoes further metabolism. Ethylenethiurammonosulfide, ethylenethiuroum disulfide, and sulfur are also metabolites.

Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.636

from HSDB

The major metabolite is ethylene thiourea comprising almost 24% of the bioavailable dose in urine and bile. Ethylenethiourea residues in the thyroid and the liver were less than 1 ppm and were nondetectable after 24 hr.

Purdue University; National Pesticide Information Retrieval System, Mancozeb Fact Sheet No. 125 (1987)

from HSDB

Environmental and mammalian degradation of the ethylenebisdithiocarbamate compounds into ethylene thiourea, aknown mutagen, teratogen, and carcinogen, as well as an antithyroid compound, has raised suspicions about theseagents and fostered requests for more indepth studies. There is also evidence that ethylene thiourea may be formedwhile processing and cooking ethylenebisdithiocarbonatecontaminated products. Few additional, definitive, and morerecent studies have yielded any evidence of consequence concerning health hazards. /Ethylenebisdithiocarbamatecompounds/

Klaassen, C.D., M.O. Amdur, Doull J. (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons. 5th ed. New York, NY:McGrawHill, 1995., p. 679

from HSDB

The weight of evidence supports grouping of mancozeb, maneb, and metiram by a common mechanism of toxicity forthyroid effects. Thyroid toxicity induced by the ethylenebisdithiocarbamates (EBDCs) has been attributed to themetabolism of these chemicals to ETU /Ethylene thiourea/. Although the dimethyldithiocarbamates (DMDC) ziram andferbam, and perhaps thiram, also produce thyroid effects in the rat, these chemicals are not metabolized to ETU, andthe mechanism by which they induce thryoid effects has not been established. Thus, /USEPA/ concludes that there issufficient evidence to support grouping only EBDCs mancozeb, maneb, and metiram based on a common mechanismfor the induction of thyroid effects. The weight of evidence does not support grouping the dithiocarbamates by acommon mechanism of toxicity for neuropathy because: a) the pattern of neuropathology that is produced by differentdithiocarbamates is not consistent; b) although the neuropathy produced by diethyldithiocarbamate has been linked withthe formation of CS2, the neuropathy produced by disulfiram is not mediated by the formation of CS2; c) there are nodata showing that the EBDCs are metabolized to CS2 in vivo; and d) NaDMDC and ferbam are metabolized to CS2,but these dithiocarbamates do not produce neuropathy.

USEPA/Health Effects Division/Office of Pesticide Programs: The Determination of Whether Dithiocarbamate Pesticides Share aCommon Mechanism of Toxicity (December 2001). Available from, as of March 29, 2010:http://www.epa.gov/oppsrrd1/cumulative/dithiocarb.pdf

from HSDB

... The human promyelocytic cell line THP1 was used as in vitro model to study the effects of mancozeb and its mainmetabolite ethylenthiourea (ETU) on lipopolysaccharide (LPS)induced tumor necrosis factoralpha (TNF) release.Mancozeb, but not ETU, at noncytotoxic concentrations (1100 ug/mL), induced a dose and timedependent inhibitionof LPSinduced TNF release, reflecting in vivo data. The modulatory effect observed was not limited to mancozeb butalso other ethylenebisdithiocarbamates (EBDTCs), namely zineb and ziram, /which/ showed similar inhibitory effects.Mancozeb must be added before or simultaneously to LPS in order to observe the effect, indicating that it acts on earlyevents triggered by LPS. It is known that nuclear factorkappaB (NFkappaB) tightly regulates TNF transcription. Wecould demonstrate that mancozeb, modulating LPSinduced reactive oxygen species generation, prevented IkappaBdegradation and NFkappaB nuclear translocation, which in turn resulted in decreased TNF production. To furtherunderstand the mechanism of the effect of mancozeb on TNF transcription, THP1 cells were transfected with NFkappaB promoterluciferase construct, and the effect of mancozeb on luciferase activity was measured. Cellstransfected with promoter constructs containing kappaB site showed decreased LPSinduced luciferase activity relativeto control after mancozeb treatment, confirming NFkappaB binding as an intracellular target of mancozeb. Abstract:PubMed

Corsini E, et al; Toxicol Appl Pharmacol 212 (2): 8998 (2006). Available from, as of March 22, 2010:

from HSDB

8.4 Mechanism of Action

https://pubchem.ncbi.nlm.nih.gov/compound/EBDChttps://pubchem.ncbi.nlm.nih.gov/compound/EBDChttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/ethylenethioureahttps://pubchem.ncbi.nlm.nih.gov/compound/Ethylenethiuram%20monosulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/sulfurhttps://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/Ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/metiramhttps://pubchem.ncbi.nlm.nih.gov/compound/Ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/ziramhttps://pubchem.ncbi.nlm.nih.gov/compound/ferbamhttps://pubchem.ncbi.nlm.nih.gov/compound/thiramhttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/metiramhttps://pubchem.ncbi.nlm.nih.gov/compound/diethyldithiocarbamatehttps://pubchem.ncbi.nlm.nih.gov/compound/disulfiramhttps://pubchem.ncbi.nlm.nih.gov/compound/ferbamhttp://www.epa.gov/oppsrrd1/cumulative/dithiocarb.pdfhttps://pubchem.ncbi.nlm.nih.gov/compound/lipopolysaccharidehttps://pubchem.ncbi.nlm.nih.gov/compound/zinebhttps://pubchem.ncbi.nlm.nih.gov/compound/ziramhttps://pubchem.ncbi.nlm.nih.gov/compound/oxygenhttp://www.ncbi.nlm.nih.gov/pubmed/16112155?dopt=Abstract



9 Use and Manufacturing

Mancozeb is a polymeric mixture of a zinc salt and the chemical maneb.Tomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council

from HSDB

Mancozeb is produced by reaction of a concentrated solution of zinc sulfate with a suspension of maneb in water.Muller F et al; Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (2008). NY, NY: John Wiley & Sons; Fungicides, Agricultural.Online Posting Date: January 15, 2010.

from HSDB

9.1 Methods of Manufacturing

Mancozeb (Dithane M45) is essentially a combination of maneb and zineb.Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology Diagnosis and Treatment of Human Poisoning. New York, NY: ElsevierScience Publishing Co., Inc. 1988., p. 1100

from HSDB

Mancozeb is a complex of zinc and maneb containing 20% of manganese and 2.55% of zinc. Chemical name ismanganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt.

Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985to Present., p. VA12 (89) 92

from HSDB

A complete list of currently registered active pesticide products can be found in the National Pesticide InformationRetrieval System's USEPA/OPP Registered and Cancelled Pesticide Product Database. These pesticide products areregistered for use in the U.S. but approved products may change periodically and so federal, state and local authoritiesmust be consulted for currently approved products.

National Pesticide Information Retrieval System's USEPA/OPP Registered and Cancelled Pesticide Product Database. Mancozeb(8018017). Available from, as of March 15, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Acrobat MZ Fungicide (BASF): Mancozeb 60%, Morpholine, 3(3(4chlorophenyl)3(3,4dimethoxyphenyl)1oxo2propenyl) 9%

National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Cuprofix MZ Disperss (United Phosphorus): Mancozeb 30.4%, Basic cupric sulfate 22.1%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Dithane DF Rainshield (Dow): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Dithane F45 Flowable Mancozeb Agricultural Fungicide (Dow): Mancozeb 37%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Dithane M45 Fungicide (Dow): Mancozeb 80%

9.2 Formulations/Preparations

https://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20sulfatehttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/zinebhttps://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/manganesehttps://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manganese%20ethylenebis%28dithiocarbamate%29https://pubchem.ncbi.nlm.nih.gov/compound/zinchttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Morpholinehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Phosphorushttps://pubchem.ncbi.nlm.nih.gov/compound/cupric%20sulfatehttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/




from HSDB

Drexel Mancozeb Technical: Mancozeb 88%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Duosan WSB Wettable Powder Turf and Ornamental Fungicide (ScottsSierra): Mancozeb 64%, Thiophanatemethyl15.6%


from HSDB

Dupont Mankocide fungicide: Mancozeb 15%, Copper hydroxide 46.1%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Dupont Manzate 80WP: Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Dupont Manzate Flowable: Mancozeb 37%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Dupont Manzate Prostick: Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Evolve Potato Seed Piece Treatment Fungicide (Bayer): Mancozeb 6%, Thiophanatemethyl 2.5%, Cymoxanil 1%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Formec 80 Turf & Ornamental Fungicide (PBI/Gordon): Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

GauchoMZ potato seedpiece treatment (Gaucho): Mancozeb 6%, Imidacloprid 1.25%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Gavel 75 DF Agricultural Fungicide (Gowan): Mancozeb 66.7%, Zoxamide 8.3%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Grain Guard (Chemtura): Mancozeb 50%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Junction (Sepro): Mancozeb 15%, Copper hydroxide 46.1%

http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Duosanhttps://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Copper%20hydroxidehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttps://pubchem.ncbi.nlm.nih.gov/compound/Cymoxanilhttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Imidaclopridhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Zoxamidehttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Copper%20hydroxide




from HSDB

Mancozeb seed protectant fungicide (Ellis): Mancozeb 6%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Maxim MZ (Syngenta): Mancozeb 5.7%, Fludioxonil 0.5%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Moncoat MZ (Nichino): Mancozeb 6%, Flutolanil 1.5%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Penncozeb Technical (United Phosphorus): Mancozeb 88%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Penncozeb Turf and Ornamentals Fungicide (United Phosphorus): Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Pentathlon (Sepro): Mancozeb 37%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Pentathlon DF Fungicide Dispersible Granules (Sepro): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Potato Seed Protector PS (Ellis): Mancozeb 8%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Potato Seed Treater AStrep (Ellis): Mancozeb 8%, Streptomycin sesquisulfate 0.02%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Protect DF (Cleary): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

P.S.T. Plus Bark (Simplot): Mancozeb 6%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

RH0611 (Dow): Mancozeb 60%, Myclobutanil 2.25%

http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Fludioxonilhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Flutolanilhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Penncozebhttps://pubchem.ncbi.nlm.nih.gov/compound/Phosphorushttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Penncozebhttps://pubchem.ncbi.nlm.nih.gov/compound/Phosphorushttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Streptomycin%20sesquisulfatehttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Myclobutanil




from HSDB

Ridomil Gold MZ (Syngenta): Mancozeb 64%, MetalaxylM 4%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Ridomil Gold MZ WG (Syngenta): Mancozeb 64%, MetalaxylM 4%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

SA50 Dithane M45 (Southern Agricultural Insecticides): Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Tops MZ Potato seedpiece treatment fungicide (Bayer): Mancozeb 6%, Thiophanatemethyl 2.5%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

TopsMZGaucho potato seedpiece treatment (Bayer): Mancozeb 6%, Thiophanatemethyl 2.5%, Imidacloprid 1.25%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Wingman (Phoenix Environmental): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/

from HSDB

Blecar MN, powder for seed treatment (480 g/kg); Dithane LF, suspension concentrate (flowable) (455 g/L); Acarie M,Crittox MZ, Dithane M45, Dithane 945, Manzate, wettable powder (600 or 800 g mancozeb/kg); Dithane M 45Poudrage, dustable powder (60 g/kg).

Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual A World Compendium. 8th ed. Thornton Heath, UK: The British CropProtection Council, 1987., p. 511

from HSDB

... Dispersible powder, suspension concentrate, and powder for dry seed treatment. Mixtures; (mancazeb +) metalaxyl;benalaxyl; oxadixyl; cymoxanil; carbendazim; captan; fosetylaluminum; zineb; copper oxychloride; sulfur; dinocap;folpet; myclobutanil; fenpropimorph; Bordeaux mixture; pyrifenox; penconazole; and many others.

Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p.762

from HSDB

Dust, flowable suspension, liquid flowable, water dispersible granules, wettable powder.Meister, R.T., Sine, C; Crop Protection Handbook Volume 95. Meister Media Worldwide, Willoughby, OH 2009, p. 350

from HSDB

3465 tons are used annuallyHalfon E et al; Chemosphere 33: 154362 (1996)

from HSDB

9.3 Consumption

http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Ridomil%20Goldhttps://pubchem.ncbi.nlm.nih.gov/compound/Metalaxyl-Mhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Ridomil%20Goldhttps://pubchem.ncbi.nlm.nih.gov/compound/Metalaxyl-Mhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Dithane%20M-45http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttps://pubchem.ncbi.nlm.nih.gov/compound/Imidaclopridhttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Crittoxhttps://pubchem.ncbi.nlm.nih.gov/compound/Dithane%20M-45https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttps://pubchem.ncbi.nlm.nih.gov/compound/metalaxylhttps://pubchem.ncbi.nlm.nih.gov/compound/benalaxylhttps://pubchem.ncbi.nlm.nih.gov/compound/oxadixylhttps://pubchem.ncbi.nlm.nih.gov/compound/cymoxanilhttps://pubchem.ncbi.nlm.nih.gov/compound/carbendazimhttps://pubchem.ncbi.nlm.nih.gov/compound/captanhttps://pubchem.ncbi.nlm.nih.gov/compound/zinebhttps://pubchem.ncbi.nlm.nih.gov/compound/sulfurhttps://pubchem.ncbi.nlm.nih.gov/compound/folpethttps://pubchem.ncbi.nlm.nih.gov/compound/myclobutanilhttps://pubchem.ncbi.nlm.nih.gov/compound/fenpropimorphhttps://pubchem.ncbi.nlm.nih.gov/compound/Bordeaux%20mixturehttps://pubchem.ncbi.nlm.nih.gov/compound/pyrifenoxhttps://pubchem.ncbi.nlm.nih.gov/compound/penconazolehttps://pubchem.ncbi.nlm.nih.gov/compound/water



In the United Kingdom, mancozeb is used on wheat, winter barley, spring barley, and oats at 253, 12, 1, and 1 tons peryear, respectively.

Harris GL; in Pesticide Loss to Water A Review of Possible Agricultural Management Opportunities to Minimize PesticideMovement. BCPC Mongr, Vol 62 pp. 3718 (1995)

from HSDB

Mancozeb use on various fruits and vegetables, including apples, potatoes, tomatoes, and wheat, in 1987 was8,660,507 lbs active ingredient per year.

Gianessi LP; US Pesticide Use Trends: 19661989. Resources for the Future, Washington, DC (1992)

from HSDB



10 Identification

Product analysis /is/ by decomposition with acid and measuring the carbon disulfide liberated, either by gas liquidchromatography or by a titrimetric method. Residues /may be/ determined by reaction with acid of the liberated carbondisulfide which is measured by standard methods.

Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.636

from HSDB

EMSLC Method 630. The Determination of Dithiocarbamate Pesticides in Municipal and Industrial Wastewater by UVVIS Spectrophotometry.

USEPA; EMMI. EPA's Environmental Monitoring Methods Index. Version 1.1. PC# 4082. Rockville, MD: Government Institutes(1997)

from HSDB

10.1 Analytic Laboratory Methods

https://pubchem.ncbi.nlm.nih.gov/compound/carbon%20disulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20disulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/Dithiocarbamate



11 Safety and Hazards

11.1 Hazards Identification

Signal: WarningGHS Hazard StatementsH317: May cause an allergic skin reaction [Warning Sensitization, Skin Category 1]H320: Causes eye irritation [Warning Serious eye damage/eye irritation Category 2B]H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity,repeated exposure Category 2]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard Category 1]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, longtermhazard Category 1]Precautionary StatementsP260: Do not breathe dust/fume/gas/mist/vapors/spray.P261: Avoid breathing dust/fume/gas/mist/vapors/spray.P264: Wash ... thoroughly after handling.P272: Contaminated work clothing should not be allowed out of the workplace.P273: Avoid release to the environment.P280: Wear protective gloves/protective clothing/eye protection/face protection.P302+P352: IF ON SKIN: wash with plenty of water.P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present andeasy to do continue rinsing.P314: Get medical advice/attention if you feel unwell.P321: Specific treatment (see ... on this label).P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.P337+P313: IF eye irritation persists: Get medical advice/attention.P363: Wash contaminated clothing before reuse.P391: Collect spillage.P501: Dispose of contents/container to ...

from NITECMC

View GHS Classification from all (3) sources.

11.1.1 GHS Classification

Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

from ILOICSC

11.1.2 Fire Hazard

Finely dispersed particles form explosive mixtures in air.

from ILOICSC

11.1.3 Explosion Hazard

CombustibleInternational Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html

11.1.4 Fire Potential

https://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.inchem.org/pages/icsc.html



from HSDB

The substance is irritating to the eyes and the respiratory tract, and is mildly irritating to the skin.International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html

from HSDB

11.1.5 Skin, Eye, and Respiratory Irritations

11.2 Safety and Hazard Properties

Dust explosion possible if in powder or granular form, mixed with air.

from ILOICSC

11.2.1 Physical Dangers

Decomposes on heating and on contact with acids and moisture. This produces toxic and irritating fumes includingsulfur oxides, nitrogen oxides, zinc oxide, manganese oxide, hydrogen sulfide, carbon sulfide, ethylene thiuram sulfide,ethylene bisisothiocyanate, ethylene urea and 2mercaptoimidazoline.

from ILOICSC

11.2.2 Chemical Dangers

Finely dispersed particles form explosive mixtures in air.International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html

from HSDB

11.2.3 Explosive Limits and Potential

11.3 First Aid Measures

Fresh air, rest. Refer for medical attention.

from ILOICSC

11.3.1 Inhalation First Aid

Remove contaminated clothes. Rinse and then wash skin with water and soap.

from ILOICSC

11.3.2 Skin First Aid

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medicalattention.

from ILOICSC

11.3.3 Eye First Aid

http://www.inchem.org/pages/icsc.htmlhttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20oxidehttps://pubchem.ncbi.nlm.nih.gov/compound/hydrogen%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethylenethiuram%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethyleneureahttps://pubchem.ncbi.nlm.nih.gov/compound/2-mercaptoimidazolinehttp://www.inchem.org/pages/icsc.htmlhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/water



Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).

from ILOICSC

11.3.4 Ingestion First Aid

Powder, water spray, foam, carbon dioxide.International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html

from HSDB

11.4 Fire Fighting Measures

Use water spray, powder, foam, carbon dioxide.

from ILOICSC

11.4.1 Fire Fighting

11.5 Accidental Release Measures

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilledsubstance into sealable containers. Carefully collect remainder. Then store and dispose of according to localregulations. Do NOT wash away into sewer.

from ILOICSC

11.5.1 Spillage Disposal

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sitesshould be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shallbe lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to apermitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that"pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation,dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage thechemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in orderto determine the appropriate local, state and federal requirements for disposal.

from HSDB

Do NOT wash away into sewer. Sweep spilled substance into sealable containers. Carefully collect remainder, thenremove to safe place.


from HSDB

11.5.2 Cleanup Methods

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numberU114, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

40 CFR 240280, 300306, 702799 (7/1/2008)

from HSDB

11.5.3 Disposal Methods

https://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20dioxidehttp://www.inchem.org/pages/icsc.htmlhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20dioxidehttp://www.inchem.org/pages/icsc.html



A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence timeof 0.1 to 2 seconds. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C andresidence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bedincineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, andlonger for solids. /Ethylenebisdithiocarbamate/

USEPA; Engineering Handbook for Hazardous Waste Incineration p.313 (1981) EPA 68033025

from HSDB

Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless inaccordance with the requirements of a National Pollutant Discharge Eliminations System (NPDES) permit and thepermitting authority has been notified in writing prior to discharge. ... For guidance, contact your State Water Board orRegional Office of the Environmental Protection Agency.

USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 1045 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home

from HSDB

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personalcontact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of thecleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by theworkers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place ofwork for cleaning.

from HSDB

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits ordetrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including theform of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and thehygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such thatthe wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn.In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

from HSDB

Avoid long term exposure, even to small quantities. Keep away from flames and sparks.Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook. 2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry,1987., p. A251/Aug 87

from HSDB

Manufacturers of products formulated as wettable powders must prohibit application of wettable powder products to turfon sod farms and application of wettable powder formulations to turf unless packaged in water soluble packaging


from HSDB

Manufacturers of products formulated as liquids must prohibit application of liquids by aerial or chemigation methods togolf courses and application of liquids aerially to sod farms.


from HSDB

Manufacturers of products formulated as dusts must require closed systems for commercial seedpiece treatment.USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 104 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home

from HSDB

Human flagging is prohibited. Flagging to support aerial application is limited to use of the Global Positioning System(GPS) or mechanical flaggers.


from HSDB

11.5.4 Other Preventative Measures

https://pubchem.ncbi.nlm.nih.gov/compound/Waterhttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#home



Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, usedetergent and hot water. Keep and wash PPE separately from other laundry. Discard clothing or other absorbentmaterials that have been drenched or heavily contaminated with this product's concentrate. Do not reuse them.


from HSDB

Users should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Users should removeclothing/ PPE immediately if pesticide gets inside, then wash thoroughly and put on clean clothing. Users shouldremove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible,wash thoroughly and change into clean clothing


from HSDB

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 24 hours.USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 111 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home

from HSDB

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Onlyprotected handlers may be in the area during application.


from HSDB

This pesticide is toxic to aquatic organisms. Do not apply directly to water, or to areas where surface water is present, orto intertidal areas below the mean high water mark. Do not contaminate water when cleaning equipment or disposingof equipment washwater or rinsate.


from HSDB

11.6 Handling and Storage

Provision to contain effluent from fire extinguishing. Separated from acids and food and feedstuffs. Dry. Keep in a wellventilated room.

from ILOICSC

11.6.1 Safe Storage

Provision to contain effluent from fire extinguishing. Separated from acids, food and feedstuffs. Dry. Keep in a wellventilated room.


from HSDB

11.6.2 Storage Conditions

11.7 Exposure Control and Personal Protection

Workplace Environmental Exposure Level (WEEL): 8hr Timeweighted Average (TWA) 1 mg/cu m, dermalsensitization.

11.7.1 Other Occupational Permissible Levels

https://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.inchem.org/pages/icsc.html



American Industrial Hygiene Association; Emergency Response Planning Guidelines & Workplace Enviromental Exposure Levels.Fairfax, VA 2009, p. 41

from HSDB

TLV (NOTESTABLISHED):.

from ILOICSC

11.7.2 Occupational Exposure Limits

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly whendispersed.

from ILOICSC

11.7.3 Inhalation Risk

The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin.

from ILOICSC

11.7.4 Effects of Short Term Exposure

Repeated or prolonged contact may cause skin sensitization. See Notes.

from ILOICSC

11.7.5 Effects of Long Term Exposure

OPP RfD= 0.003 mg/kg; WHO RfD= 0.05 mg/kgUSEPA/OPP; Health Effects Div RfD/ADI Tracking Report p.36 (8/26/91)

from HSDB

11.7.6 Acceptable Daily Intakes

Tolerances for residues of a fungicide which is a coordination product of zinc ion and maneb (manganous ethylenebisdithiocarbamate) containing 20 percent manganese, 2.5 percent zinc, and 77.5 percent ethylenebisdithiocarbamate(the whole product calculated as zinc ethylenebisdithiocarbamate), are established as follows:

Commodity Parts permillion

Apple 7

Asparagus (negligible residue) 0.1

Banana 4.0

Banana, pulp 0.5

Barley, bran 20

Barley, flour 20

Barley,grain 5

Barley, pearled barley 20

Barley, straw 25

11.7.7 Allowable Tolerances

https://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/manganesehttps://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20ethylenebisdithiocarbamate



Beet, sugar, roots 2

Beet, sugar, tops 65

Carrot, roots 2

Cattle, kidney 0.5

Cattle, liver 0.5

Celery 5

Corn, field, forage 5

Corn, field, grain 0.1

Corn, field, stover 5

Corn, pop, grain 0.5

Corn, pop, stover 5

Corn, sweet, forage 5

Corn, sweet, kernel plus cob with husks removed 0.5

Corn, sweet, stover 5

Cotton, undelinted seed 0.5

Crabapple 10

Cranberry 7

Cucumber 4

Fennel 10

Goat, kidney 0.5

Goat, liver 0.5

Grape 7

Hog, kidney 0.5

Hog, liver 0.5

Horse, kidney 0.5

Horse, liver 0.5

Melon 4

Oat, bran 20

Oat, flour 20

Oat, grain 5

Oat, groats/rolled oats 20

Oat, straw 25

Onion, bulb 0.5

Papaya (whole fruit with no residue present in the edible pulp after the peel is removed anddiscarded) 10

Peanut 0.5

Peanut, hay 65

Pear 10

Poultry, kidney 0.5

Poultry, liver 0.5

Quince 10



Rye, bran 10

Rye, grain 5

Rye, straw 25

Sheep, kidney 0.5

Sheep, liver 0.5

Squash, summer 4

Tomato 4

Wheat, bran 20

Wheat, flour 20

Wheat, germ 20

Wheat, grain 5

Wheat, middlings 20

Wheat, shorts 20

Wheat, straw 25

40 CFR 180.176(a) (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations.Available from, as of February 24, 2010: http://www.gpoaccess.gov/ecfr

from HSDB

A timelimited tolerance is established for combined residues of the fungicide mancozeb, calculated as zincethylenebisdithiocarbamate and it's metabolite ETU in connection with use of the pesticide under a section 18emergency exemption granted by EPA. The tolerance will expire and is revoked on the dates specified. Commodity:ginseng; Parts Per Million: 2.0; Expiration/Revocation Date: 12/31/10

40 CFR 180.176(b) (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations.Available from, as of March 2, 2010: http://www.gpoaccess.gov/ecfr

from HSDB

NO open flames.

from ILOICSC

11.7.8 Fire Prevention

Closed system, ventilation, explosionproof electrical equipment and lighting. Prevent deposition of dust.

from ILOICSC

11.7.9 Explosion Prevention

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

from ILOICSC

11.7.10 Exposure Prevention

Use local exhaust or breathing protection.

from ILOICSC

11.7.11 Inhalation Prevention

http://www.gpoaccess.gov/ecfrhttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20ethylenebisdithiocarbamatehttp://www.gpoaccess.gov/ecfr



Protective gloves. Protective clothing.

from ILOICSC

11.7.12 Skin Prevention

Wear safety goggles or eye protection in combination with breathing protection.

from ILOICSC

11.7.13 Eye Prevention

Do not eat, drink, or smoke during work. Wash hands before eating.

from ILOICSC

11.7.14 Ingestion Prevention

EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forLiquid Concentrate. Mixers, loaders, applicators, and other handlers must wear: longsleeved shirt, long pants, shoesand socks, and chemicalresistant gloves (except pilots, groundboom applicators, and airblast applicators). In addition,mixers/loaders supporting chemigation applications to turf on sod farms must wear a NIOSHapproved respirator with adust/mist filter with MSHA/NIOSH approval number prefix TC21C or any N*, R, P, or HE filter. *Instruction toregistrant: Drop the "N" type filter from the respirator statement if the pesticide product contains or is used with oil.


from HSDB

EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forLiquid Concentrate, Liquid ReadyToUse, and Dry Flowable Formulations. Mixers, loaders, applicators, and otherhandlers must wear: longsleeved shirt, long pants, shoes and socks, and chemicalresistant gloves (except handlerswho are bagging the treated seed or sewing the bags).


from HSDB

EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forWettable Powder (WP) Formulations that are not packaged in water soluble packaging. (For all uses except seed andseed piece treatment). Mixer, loaders, applicators, and other handlers must wear: longsleeved shirt, long pants, shoesand socks. In addition, all handlers except pilots, groundboom applicators, and airblast applicators must wear: chemicalresistant gloves, and a NIOSHapproved respirator with a dust/mist filter with MSHA/NIOSH approval number prefix TC21C or any N*, R, P, or HE filter. Instruction to Registrant: Drop the "N" type filter from the respirator statement if thepesticide product contains, or is used with, oil.


from HSDB

EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forWettable Powder (WP) Formulations that are not packaged in water soluble packaging. (For products with directions foruse as a seed treatment). Mixer, loaders, applicators, and other handlers must wear: longsleeved shirt, long pants,shoes and socks. In addition, all handlers (except handlers who are bagging the treated seed or sewing the bags) mustwear: chemicalresistant gloves, and a NIOSHapproved respirator with a dust/mist filter with MSHA/NIOSH approvalnumber prefix TC21C or any N*, R, P, or HE filter. *Instruction to Registrant: Drop the "N" type filter from the respiratorstatement if the pesticide product contains, or is used with, oil.


from HSDB

11.7.15 Protective Equipment and Clothing

http://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#home



EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) for (WP)Formulations that are packaged in water soluble packaging. Mixers, loaders, applicators, and other handlers must wear:longsleeved shirt, long pants, shoes and socks, and chemicalresistant gloves (except pilots, groundboom applicators,and airblast applicators). In addition, handlers performing tasks, such as spill cleanup, that involve contact with the drywettable powder must wear: a NIOSHapproved respirator with a dust/mist filter with MSHA/NIOSH approval numberprefix TC21C or any N*, R, P, or HE filter. *Instruction to Registrant: Drop the "N" type filter from the respiratorstatement if the pesticide product contains, or is used with, oil.


from HSDB

EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) for DustFormulation and Wettable Powder Formulations (applied dry). "Loaders, applicators, and other handlers must wear:longsleeved shirt, long pants, shoes and socks, chemicalresistant gloves, and a NIOSHapproved respirator with adust/mist filter with MSHA/NIOSH approval number prefix TC21C or any N*, R, P, or HE filter. *Instruction toRegistrant: Drop the "N" type filter from the respirator statement if the pesticide product contains, or is used with, oil.


from HSDB

Watersoluble packets when used correctly qualify as a closed mixing/loading system under the Worker ProtectionStandard for Agricultural Pesticides [40 CFR 170.240(d)(4)].


from HSDB

Engineering Controls: Pilots must use an enclosed cockpit that meets the requirements listed in the Worker ProtectionStandard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)].


from HSDB

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involvescontact with anything that has been treated, such as soil or water, is: Coveralls, Shoes and socks, and Chemicalresistant gloves made of any waterproof material.


from HSDB

11.8 Transport Information

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person isregistered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, andin condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171177)./

49 CFR 171.2 (7/1/99)

from HSDB

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA DangerousGoods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to befollowed by all IATA Member airlines when transporting hazardous materials.

IATA. Dangerous Goods Regulations. 40th Ed. Montreal, Canada and Geneva, Switzerland: International Air Transport Association,Dangerous Goods Regulations, 1999., p. 216

from HSDB

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals.Detailed recommendations for individual substances and a number of recommendations for good practice are includedin the classes dealing with such substances. A general index of technical names has also been compiled. This index

11.8.1 Shipment Methods and Regulations

https://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/Waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#home



should always be consulted when attempting to locate the appropriate procedures to be used when shipping anysubstance or article.

IMDG; International Maritime Dangerous Goods Code; International Maritime Organization p.3270, 6219, 6220, and 6221 (1998)

from HSDB

Airtight. Do not transport with food and feedstuffs. Marine pollutant.

from ILOICSC

11.8.2 Packaging and Labelling

Symbol: Xi; R: 3743; S: (2)824/2546

from ILOICSC

11.8.3 EC Classification

UN Hazard Class: 4.2; UN Subsidiary Risks: 4.3; UN Pack Group: III

from ILOICSC

11.8.4 UN Classification

Transport Emergency Card: TEC (R)42S2210.

from ILOICSC

11.8.5 Emergency Response

11.9 Regulatory Information

(AZ) ARIZONA 21 ug/lUSEPA/Office of Water; FederalState Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal DrinkingWater Standards and Guidelines (11/93) To Present

from HSDB

(ME) MAINE 6 ug/lUSEPA/Office of Water; FederalState Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal DrinkingWater Standards and Guidelines (11/93) To Present

from HSDB

11.9.1 State Drinking Water Guidelines

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject toeffluent limitations. /Zinc and compounds/

40 CFR 401.15 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Availablefrom, as of March 2, 2010: http://www.gpoaccess.gov/ecfr

from HSDB

11.9.2 Clean Water Act Requirements

11.9.3 CERCLA Reportable Quantities

https://pubchem.ncbi.nlm.nih.gov/compound/Waterhttps://pubchem.ncbi.nlm.nih.gov/compound/Zinchttp://www.gpoaccess.gov/ecfr



Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, whenthere is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantityof 5000 lb or 2270 kg. The toll free number of the NRC is (800) 4248802. The rule for determining when notification isrequired is stated in 40 CFR 302.4 (section IV. D.3.b). /Ethylenebisdithiocarbamic acid, salts and esters/


from HSDB

U114; As stipulated in 40 CFR 261.33, when ethylenebisdithiocarbamic acid, salts and esters, as a commercialchemical product or manufacturing chemical intermediate or an offspecification commercial chemical product or amanufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or Statehazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or otherdebris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of thiswaste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). /Ethylenebisdithiocarbamicacid, salts and esters/


from HSDB

11.9.4 RCRA Requirements

Tolerances for residues of a fungicide which is a coordination product of zinc ion and maneb (manganous ethylenebisdithiocarbamate) containing 20 percent manganese, 2.5 percent zinc, and 77.5 percent ethylenebisdithiocarbamate(the whole product calculated as zinc ethylenebisdithiocarbamate), are established as follows:Commodity

Apple

Asparagus (negligible residue)

NIH CHEMISTRY Search Compounds DATABASE PUBCHEM … · 19/09/2016 MANCOZEB | C8H12MnN4S8Zn PubChem...

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