Curriculum Vitae

Name: Mazhar Iqbal (Tamgha-e-Imtiaz)Current Position: Deputy Chief Scientist, Group Leader & Manager ORIC,

Drug Discovery and Structural Biology, Health Biotechnology Division, National Institute for Biotechnology & Genetic Engineering (NIBGE), Faisalabad, Pakistan.

Academic Position Faculty (Professor),Pakistan Institute of Engineering & Applied Sciences (PIEAS), Islamabad

Telephone: +92-41-9201403: Fax: +92-41-9201322.Email: hamzamgondal@yahoo.com & hamzamgondal@gmail.comDate & Place of Birth: 1st December 1967, Mandi Bahauddin, Pakistan.

CNIC: 91400-0137622-3

Passport No.: ET1336223

BIOGRAPHY:

2018 to due date Deputy Chief Scientist, Group Leader and Manager ORIC, NIBGE, Faisalabad.

2008 - 2018 Principal Scientist and Group Leader, Drug Discovery and Structural Biology, Health Biotechnology Division, NIBGE, Faisalabad.

2005 – 2007 Postdoctoral Research Fellow, Medicinal Chemistry, The University of Liverpool, UK, funded by American pharmaceutical company, Romark (pvt), Ltd., Tampa Florida.

2001 – 2005 Ph.D. Chemistry, The University of Liverpool, UK. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420456

1995 – 2000 Senior Scientific Officer, NIBGE, Faisalabad.

1993 – 1995 Research Trainee Fellow, NIBGE, Faisalabad.

1992 – 1993 Asstt. Technical Officer, Descon Chemical Industries, (Pvt) Ltd., Lahore.

1989 – 1991 M.Sc. (Chemistry), University of The Punjab, Lahore.

RESEARCH INTERESTS:

Þ Developing entrepreneurs from research seed ideas. Translation of innovation to commercialization. Þ Research themes on the interface of Drug Discovery, Medicinal, Organic, Analytical and Biochemistry. Þ Discovery & development of anti-viral, anti-cancer, anti-bacterial, anti-parasitic and anti-fungal agentsÞ Vaccines development against bacteria and viruses prevalent in Pakistan.Þ Commercialization of analytical services: aflatoxins analysis services to food exporters and different

companies as well as institutions, analysis of various analytes using LCMS/MS & GCMS/MS techniques.

HONORS / AWARDS / FELLOWSHIPS:

Þ Awarded a national civil award, Tamgha-e-Imtiaz, by President of Pakistan on National Day March 23, 2019, for the services/contribution in the area of Chemistry

Þ Research Productivity Award (2016) from Pakistan Council for Science and Technology, Ministry of Science and Technology, Pakistan

Þ Research Productivity Award (2015) from Pakistan Council for Science and Technology, Ministry of Science and Technology, Pakistan

Þ Research Productivity Award (2014) from Pakistan Council for Science and Technology, Ministry of Science and Technology, Pakistan

Þ Gold Medal & Scientist of the Year Award (2012) from Pakistan Atomic Energy Commission Þ Won a 4 Months Fellowship (2012) at Agri-food and Biosciences Institute, UK, funded by International

Atomic Energy Agency (IAEA) to get training on veterinary drug residues using LC-MS/MS system Þ Won a TROSS Award (2001) from The Ministry of Science & Technology, Govt. of PakistanÞ Won a Postdoctoral Fellowship (2004) from Romark Laboratories to work at The University of Liverpool

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Management experience:

As an acting Head of Division:

Since July 2013, I am serving as an acting Head of Division during the absence of Dr Shahid M. Baig.

Represented Health Biotechnology Division in several important events i.e. two Coordination Meetings, Chairman PAEC, Member Science visits, IAEA professionals’ visits etc.

As a Manager ORIC:

Since June 14, 2017, I am serving as a Manager ORIC NIBGE and managing activities revolve around Research Innovation and Commercialization.

Prepared, processed and signed MOU (1) and Agreements (2) with industries.

Hosted four meetings of HEC Project Director and attended several meetings at HEC managers.

Organized, participated and supported several NIBGE Scientific events.

Submitted and pursued >174 new grant proposals to different national and international funding agencies. Several activities i.e., projects internal review, submission, award/agreements, funds release, account opening etc., pursued.

Hosted foreign professors, industrialists and academic collaborators.

Established ORIC Office infrastructure and recruited Marketing & Accounting Officers.

Participated in exhibitions and seminars.

As a Group Leader:

Serving as a Group Leader of Drug Discovery and Structural Biology group for more than one decade.

Established new laboratories (Drug Discovery, Analytical Research, Cell Culture and partly Biosafety Level-3 facilities), several research programs and four sub-groups.

Currently, leading a group of 9 Scientists, 3 Senior and Research Associates, 3 Scientific Assistants and several PhD & MPhil students.

Providing Analytical Services for the past 7 years to industries, exporters and research institutions.

RESEARCH GRANTS AWARDED BY NATIONAL/INTERNATIONAL ORGANISATIONS (as PI & Co-PI): 28

Total funding acquired from projects and commercial services Rs. 198.552 M (US$ 1.846 M)

1- Title of the project Development of Inhibitors Targeting the Viral as well as Host Factors of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A way forward to develop a high potency treatment therapy”

Participation As a P. I.Funding Agency Pakistan Science FoundationAllocated Amount Rs. 9.84 M (~US $ 60,000)Year of Funding 2020-2021

2- Title of the project Engineering the biosynthesis of iturin-A by non-ribosomal peptidesynthetase domain/module exchange in advance host strain for novel metabolites

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 3.762 M (~US $ 25,000)Year of Funding 2019-2022

3- Title of the project Process Development for Industrial Scale Cleaning of Aflatoxins from Rice Through Ultraviolet Irradiation

Participation As a P. I.

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Funding Agency Technology Development Fund Project, Higher Education Commission of PakistanAllocated Amount Rs. 14.00 M (~US $ 93,000)Year of Funding 2019-2021

4- Title of the project Development of Lateral Flow Strip and Dipstick to Detect Anti-infectious Bursal Disease Virus Antibodies In Chicken for Disease Diagnosis and Monitoring of Post Vaccination Immune Response

Participation As a Co-P. I.Funding Agency Technology Development Fund Project, Higher Education Commission of PakistanAllocated Amount Rs. 13.393 M (~US $ 90,000)Year of Funding 2019-2021

5- Title of the project "Engineering the biosynthesis of Iturin-A by non-ribosomal peptide synthetase domain/module exchange in advance host strain for novel metabolites"

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 3.7622 M (~US $ 25,000)Year of Funding 2019-2021

6- Title of the project Structural and functional characterization of PlpE protein of Pasteurella multocida as vaccine candidateParticipation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 10.887 M (~US $ 100,000)Year of Funding 2018-2020

7- Title of the project Preparation and evaluation of conjugate vaccine candidates against Salmonella Enterica serovar Typhimurium

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 4.01 M (~US $ 36,500)Year of Funding 2018-2020

8- Title of the project Cellular and molecular mechanisms involved in the progression of hepatocellular carcinoma by aflatoxin and hepatitis C virus: Implications for novel cancer therapeutics

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 3.56 M (~US $ 32,000)Year of Funding 2018-2020

9- Title of the project Development and production of antifungal fengycin and its analogues by non- ribosomal peptide synthetases domain/module exchange in advance host strain

Participation As a Co-P. I.Funding Agency Agricultural Linkage Program (ALP), Pakistan Agricultural Research CouncilAllocated Amount Rs. 3.5 M (~US $ 27,500)Year of Funding 2018-2020

10- Title of the project Strain improvement for hyper production of lipopeptide surfactin by Bacillus sp. for various industrial applications

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 2.01 M (~US $ 18,000)

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Year of Funding 2018-2020

11- Title of the project Using nanocarriers, enhancing bioavailability of naringenin: An anti-viral, anti-cancer and anti-inflammatory compound

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 3.1 M (~US $ 28,000)Year of Funding 2018-2020

12- Title of the project Raman microspectroscopy along with improved sample preparation protocols (Centrifugal Filter approach) for the diagnosis of Hepatitis C by using blood plasma samples

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 4.02 M (~US $ 36,400)Year of Funding 2018-2020

13- Title of the project Preparation of nitride and oxide-based nanostructured materials by chemical vapour deposition technique for environmental applications

Participation As a Co-P. I.Funding Agency Higher Education Commission of PakistanAllocated Amount Rs. 3.06 M (~US $ 27,500)Year of Funding 2018-2020

14- Title of the project Synthesis of Biologically Active Fluoroalkylated Aminothiazolides by Visible Light Photocatalysis

Participation As a Co-P. I.Funding Agency Higher Education Commission of Pakistan Allocated Amount Rs. 0.345 M (US $ 3400)Year of Funding 2016-2017

15- Title of the project Development of NS3/4A Protease Inhibitors Against Hepatitis C Virus Genotype 3aParticipation As a P. I.Funding Agency Higher Education Commission of Pakistan Allocated Amount Rs. 6.708 M (US $ 67,000)Year of Funding 2015-2016

16- Title of the project Palladium Catalyzed C-H Activation in tert-Amide Directed Fujiwara-Moritani Reaction

Participation As a Co-P. I.Funding Agency Higher Education Commission of Pakistan Allocated Amount Rs. 3.74 M (US $ 37,400)Year of Funding 2015-2017

17- Title of the project Molecular characterization of multidrug resistant typhoidal bacteria with specific reference to fluoroquinolones and cephalosporins and study the effect of drug resistance on bacterial virulence

Participation As a Co-P. I.Funding Agency Higher Education Commission of Pakistan Allocated Amount Rs. 3.384 M (US $ 33,800)Year of Funding 2015-2017

18- Title of the Project Diagnosis of treatable inborn metabolic disorders of intellectual disabilityName of P. I. Dr. Fazle Rabbi Awan

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Participation As a Co-P. I.Funding Agency International Centre for Genetic Engineering & Biotechnology (ICGEB), Italy Allocated Amount Euro € 45,000/- (~ Rs. 6.77 M)Year of Funding 2015-2017

19- Title of the Project Development of small molecule antiviral agents to treat Hepatitis B and C diseasesName of P. I. Dr. Mazhar IqbalParticipation As a P. I.Funding Agency Higher Education Commission, Pakistan Allocated Amount Rs. 9.9 Million (US $ 99,000)Year of Funding 2014-2016

20- Title of the Project Structural and antigenic analyses of lipopolysaccharides of typhoidal pathogensName of P. I. Dr. Mazhar IqbalParticipation As a main project coordinator (P. I.)Funding Agency International Centre for Genetic Engineering & Biotechnology (ICGEB), Italy Allocated Amount Euro € 36,000/- (~Rs. 5.41 M)

Year of Funding 2014-2016

21- Title of the Project Targeting NS3-4A Protease: A Rational Approach for Developing New Antivirals against Hepatitis C Infection based on “Medicinally Privileged Heterocyclic Scaffolds”,

Name of P. I. Dr. Muhammad Ali (COMSATS, Institute of Information Technology Abbottabad)Participation As a Co-P. I. Funding Agency Higher Education Commission, Pakistan Allocated Amount Rs. 13.27 Million (US $ 132,700)Year of Funding 2014-2017

22- Title of the Project Structural and functional characterization of the matrix protein of Newcastle disease virus

Name of P. I. Dr. Moazur RahmanParticipation As a Co-P. I. Funding Agency Higher Education Commission, Pakistan Allocated Amount Rs. 5.12 Million (US $ 51,200)Year of Funding 2013-2015

23- Title of the Project Provision of Grants to Public Sector Universities and Degree Awarding Institutions for Maintenance of Scientific Equipments, HEC

Name of P. I. Dr. Mazhar IqbalParticipation P. I.Funding Agency Higher Education Commission, PakistanAllocated Amount Rs. 1.0 Million (Received in two instalments of Rs. 500,000/- each)

Year of Funding 2012-2013

24- Title of the Project Drug Discovery of Cyclopentenones, the Potential Small Molecule Anti-viral Agents to Treat Hepatitis C Disease

Name of P. I. Dr. Mazhar IqbalParticipation As a main project coordinator (P. I.)Funding Agency Higher Education Commission, PakistanAllocated Amount Rs. 4.2 Million (US $ 42,000)Year of Funding 2011-2013

25- Title of the project Strengthening Capabilities to Monitor & Control Veterinary Drug Residues in Foodstuffs (A technical Cooperation Project among three different institutes)

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Participation As a main coordinator from NIBGE (Technical Cooperation Project). Other two counterparts of this project are: Dr Qaiser M. Khan (NIBGE) & Dr Uzma Maqbool (NIAB)

Funding Agency International Atomic Energy AgencyAllocated Amount € 188,000/- (~Rs. 28.29 M)Year of Funding 2012-2016

26- Title of the Project Provision of Grants to Public Sector Universities and Degree Awarding Institutions for Maintenance of Scientific Equipment

Name of P. I. Dr. Mazhar IqbalParticipation As a P. I. Funding Agency Higher Education Commission, Pakistan Allocated Amount Rs. 1.4 Million (US $ 9,500) Year of Funding 2012-2013

27- Title of the Project Establishment of over-expression systems for human and yeast peptide transporters with perspective of their importance in drug delivery

Name of P. I. Dr. Moazur RehmanParticipation As a Co-P. I. Funding Agency Higher Education Commission, Pakistan Allocated Amount Rs. 5.5 Millions (US $ 55,000)Year of Funding 2011-2013

28- Title of the Project Structural and functional studies of C-terminal hydrophilic tail of the human zinc transporter Znt8

Name of P. I. Dr. Moazur RehmanParticipation As a Co-P. I. Funding Agency International Centre for Genetic Engineering & Biotechnology (ICGEB), Italy Allocated Amount Euro € 42,000/- (~Rs. 6.32 M)Year of Funding 2010-2013

29- Title of the Project Structural and functional characterization of MDR efflux pumps in Salmonella enterica

serovar Typhi with perspective of drug target identificationName of P. I. Dr. Moazur RehmanParticipation As a Co-P. I. Funding Agency Higher Education Commission, Pakistan Allocated Amount Rs. 4.14 Million (US $ 41,400)Year of Funding 2010-2013

REVENUE GENERATED FROM COMMERCIAL ANALYTICAL SERVICES:

Revenue of Rs. 15 million (~US $ 140,000/-) generated from LC-MS/MS and GC-MS/MS based analytical services provided to various Food Exporters and Research/Academic Institutes (Sept. 2012 to Dec., 2019)

LIST OF ARTICLES IN IMPACT FACTOR JOURNALS

Cumulative Impact Factor: 238.5 as Per Google Scholar H-index 23, Cumulative Citation: >1556.

As per Web of Science / Publons enlisted: Publications 76, Citation 957, h-index 18

1. Khan, M., Rauf, W., Habib, F., Rahman, Iqbal, M. Screening and identification of bioactive compounds from citrus against NS3 protease of HCV-G3a by FRET assay and Mass Spectrometry, World Journal of Hepatology, 2020, Manuscript NO: 58556, Accepted and under publication process. IF = 2.77

2. Anjum, T., Iram, W., Iqbal, M., Ghaffar, A., Abbas, M. Identification of degradation products of aflatoxin B1

and B2 resulting after their biodetoxification by aqueous extracts of Acacia nilotica, World Mycotoxin Journal, 6

2020, doi: 10.3920/WMJ2018.2411. IF = 2.306

3. Tawab, A., Akbar, N., Hasssan, M., Habib, F., Ali, A., Rahman, M., Jabbar, A., Rauf, W., Iqbal, M. Mass spectrometric analysis of lipid A obtained from the lipopolysaccharide of Pasteurella multocida, RSC Advances, 2020, 10(51), 30917-30933. doi: 10.1039/d0ra05463a. IF = 3.07, Citation = 0

4. Ijaza, H., Ziaa, R., Taja, A., Jameela, F., Butt, F. K., Asim, T., Jameel, N., Abbas, W., Iqbal, M., Bajwa, S. Z., Khan, W. S. Synthesis of BiOCl nanoplatelets as the dual interfaces for the detection of glutathione linked disease biomarkers and biocompatibility assessment invitro against HCT cell lines model, Applied Nanoscience, 2020, 10(9): 3569–3576, doi: 10.1007/s13204-020-01461-4. IF = 3.2, Citation = 0

5. Shaheen, A., Tariq, A., Shehzad, A., Iqbal, M., Mirza, O., Maslov, D. A., Rahman, M. Transcriptional regulation of drug resistance mechanisms in Salmonella: where we stand and what we need to know, World Journal of Microbiology and Biotechnology, 2020, 36(6): 85, doi: 10.1007/s1127 4-020-02862 -x. IF = 2.39, Citation = 0

6. Akbar, N., Siddiqui, R., Iqbal, M., Khan, N. A. Antibacterial activities of selected pure compounds isolated from gut bacteria of animals living in polluted environments, Antibiotics, 2020, 9(4), 190; doi:10.3390/antibiotics9040190. IF = 3.89, Citation = 0

7. Walayat, K., Ahmad, M., Rasul, A., Aslam, S., Anjum, M. N., Sultan, S., Iqbal, M. Synthesis, characterization and antimicrobial activity of norfloxacin based acetohydrazides, Pakistan Journal of Pharmaceutical Sciences, 2020, 33(2), 855-860. Doi: 10.36721/PJPS.2020.33.2.SUP.855-860.1. IF = 0.596, Citation = 0

8. S. Mahboob, M. Farooq, M. Iqbal, and M. Rahman, (2018) Whole genome sequence of Pasteurella multocida serotype B:2, strain PM3, isolated from Pakistan, sequence submitted to NCBI under accession no. SDAS00000000.

9. Zafar, M., Shahzad, A., Shah, M. A., Salahuddin, M., Habib, M., Muddassar, M., Iqbal, M., Hemmatzadeh, M., Rahman, M. Characterization of the highly immunogenic VP2 protrusion domain as a diagnostic antigen for members of Birnaviridae family, Applied Microbiology and Biotechnology, 2020, 104(8), 3391-3402, doi: 10.1007/s00253-020-10458-6. IF = 3.67, Citation = 0

10. Nazir, A., Arshad, R., Bokhari, S. T., Javed, T., Bhatti, I. A., Rasheed, S., Iqbal, M., Naz, S., Khan, M. I., Khosa, M. K., Iqbal, M., Zia-ur-Rehman, M. Degradation product distribution of Reactive Red-147 dye treated by UV/H2O2/TiO2 advanced oxidation process, Journal of Materials Research and Technology, 2020, 9(3), 3168–3178, doi: 10.1016/j.jmrt.2020.01.062. IF = 3.327, Citation = 0

11. Ullah, R., Shehzad, A., Shah, M., March, M., Ismat, F., Iqbal, M., Onesti, S., Rahman, M., McPherson, M. C-terminal Domain of the Human Zinc Transporter hZnT8 is Structurally Indistinguishable from its Disease Risk Variant (R325W), International Journal of Molecular Sciences: Molecular Biophysics Section, 2020, 21(3), 926, doi: 10.3390/ijms21030926. IF = 4.183, Citation = 0

12. Hussain, S., Asi, M. R., Iqbal, M., Khalid, N., Hassan, S. W., Ariño, A. Patulin mycotoxin in mango and orange fruits, juices, pulps and jams marketed in Pakistan, Toxins, 2020, 12(1), 52; doi:10.3390/toxins12010052. IF = 3.895, Citation = 0

13. Ali, S., Hameed, S., Iqbal, M., Shahid, M., Imran, A. Functional characterization of potential PGPR exhibiting broad-spectrum antifungal activity, Microbiological Research, 2019, 229, 126389. Doi: 10.1016/j.micres.2019.126389. IF = 3.7, Citation = 0

14. Akbar, N., Khan, N. A., Sagathevan, K., Iqbal, M., Tawab, A., Siddiqui, R. Gut bacteria of Cuora amboinensis (turtle) produce broad-spectrum antibacterial molecules, Scientific Reports, 2019, 9, 17012. doi: 10.1038/s41598-019-52738-w. IF = 4.01, Citation = 0

15. Akbar, N., Siddiqui, R., Sagathevan, K., Iqbal, M., Khan, N. A. Gut Bacteria of Water Monitor Lizard (Varanus salvator) Are a Potential Source of Antibacterial Compound (s), Antibiotics, 2019, Dec;8(4): 164. doi:10.3390/antibiotics8040164. IF = 3.89, Citation = 0

16. Aziz, F., Tufail, S., Shah, M. A., Shah, M. S., Habib, M., Mirza, O., Iqbal, M., Rahman, M. In silico Epitope Prediction and Immunogenic Analysis for Penton base Epitope-focused Vaccine against Hydropericardium syndrome in chicken. Virus Research, 2019, doi: 10.1016/j.virusres.2019.197750. IF = 2.736, Citation = 0

17. Shaheen, A., Afridi, W. A., Mahboob, S., Sana, M., Zeeshan, N., Ismat, F., Mirza, O., Iqbal, M., Rahman, M. Reserpine is the new addition into the repertoire of acrb efflux pump inhibitors, Molecular Biology, 2019, 53(4), 596–605. IF = 0.932, Citation = 0

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18. Saleem, M., Tanvir, M., Akhtar, M. F., Iqbal, M., Saleem, A. Antidiabetic potential of Mangifera indica L. cv. Anwar Ratol leaves: Medicinal application of food wastes, Medicina, 2019, DOI: 10.3390/medicina55070353. IF = 1.467, Citation = 0

19. Tariq, A., Sana, M., Shaheen, A., Ismat, F., Mahboob, S., Rauf, W., Mirza, O., Iqbal, M., Rahman, M. Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts, Letters in Applied Microbiology, 2019, DOI: 10.1111/lam.13196. IF = 1.75, Citation = 1

20. Tara, N., Arslan, M., Hussain, Z., Iqbal, M., Khan, Q. M. and Afzal, M. On-site performance of floating treatment wetland macrocosms augmented with dye-degrading bacteria for the remediation of textile industry wastewater, Journal of Cleaner Production, 2019, 217, 541-548. IF = 6.395, Citation = 16

21. Tara, N., Iqbal, M., Khan, Q. M., Afzal, M. Bioaugmentation of floating treatment wetlands for the remediation of textile effluent, Water and Environment Journal, 2019, 33, 124–134. doi: 10.1111/wej.12383. IF = 1.178, Citation = 9

22. Aleem, B., Rashid, M. H., Zeb, N., Saqib, N., Ihsan, A., Iqbal, M., Ali, H. Random Mutagenesis of Super Koji (A. oryzae): Improvement in Production and Thermostability of α-Amylases for Maltose Syrup Production, BMC Microbiology, 2018, 18:200, 1-13, doi: 10.1186/s12866-018-1345-y. IF = 3.287, Citation = 2

23. Ahmad, S., Zaib, S., Jalil, S., Shafiq, M., Ahmad, M., Sultan, S., Iqbal, M., Aslam, S., Iqbal, J. Synthesis, characterization, monoamine oxidase inhibition, molecular docking and dynamic simulations of novel 2, 1-benzothiazine-2, 2-dioxide derivatives, Bioorganic Chemistry, 2018, 80, 498-510. doi: 10.1016/j.bioorg.2018.04.012. IF = 3.926, Citation = 3

24. Imran, M., Habib, F., Majeed, S., Tawab, A., Rauf, W., Rahman, M., Umer, M., Iqbal, M. LC-MS/MS based determination of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in poultry meat from the Punjab-Pakistan, Food Additives and Contaminants Part A, 2018, 35(8), 1530-1542. doi: 10.1080/19440049.2018.1463569. IF = 2.17, Citation = 10

25. Zahoor, M., Arshad, A., Yaqoob, M., Iqbal, M., Bajwa, S. Z., Soomro, R. A., Ahmad, I., Butt, F. K., Iqbal, M. Z., Wud, A., Khan, W. S. Enhanced photocatalytic performance of CeO2-TiO2 nanocomposite for degradation of crystal violet dye and industrial waste effluent, Applied Nanoscience, 2018, 8(5), 1091-1099. doi: 10.1007/s13204-018-0730-z, IF = 3.198, Citation = 7

26. Akbar, N., Siddiqui, R. B., Iqbal, M., Sagathevan, K., Khan, N. A. Gut bacteria of cockroaches are a potential source of antibacterial compound(s), Letters in Applied Microbiology, 2018, 66, 416—426, doi: 10.1111/lam.12867. IF = 1.805, Citation = 11

27. Sarwar, A., Hasan, N. M., Imran, M., Iqbal, M., Majeed, S., Brader, G., Sessitsch, A., Hafeez, F. Y. Biocontrol activity of surfactin A purified from Bacillus NH-100 and NH-217 against rice bakanae disease, Microbiological Research, 2018, 209, 1-13, doi: 10.1016/j.micres.2018.01.006. IF = 3.7, Citation = 17

28. Stachulski, A. V., Santoro, M. G., Piacentini, S., Belardo, G., Frazia, S. L., Pidathala, C., Row, E. C., Berry, N. G., Iqbal, M ., Allman, S. A., Semple, J. E., Eklov, B. M., O’Neill, P. M., Rossignol, J. F. Second Generation Nitazoxanide Derivatives: Thiazolides Are Effective Inhibitors of the Influenza A Virus, Future Medicinal Chemistry, 2018, 10(8), 851–862. doi: 10.4155/fmc-2017-0217. IF = 3.617, Citation = 7

29. Majeed, S., Boevre, M. D., Saeger, S. D., Rauf, W., Tawab, A., Habib, F., Rahman, M., Iqbal, M. Multiple Mycotoxins in Rice: Occurrence and Health Risk Assessment in Children and Adults of Punjab, Pakistan, Toxins, 2018, 10(77), 1-32. doi:10.3390/toxins10020077. IF = 3.895, Citation = 11

30. Khan, S., Iqbal, M., Tariq, M., Abbas, W. Epigenetic Regulation of HIV-1 Latency: Focus on Polycomb group (PcG) proteins, Clinical Epigenetics, 2018, 10(14), 1-19; doi: 10.1186/s13148-018-0441-z. IF = 5.496, Citation = 9

31. Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, P. R., Brasen, C., Gajhede, M., Rahman, M., Mirza, O. Chloramphenicol Uptake by the Bacterial Proton Coupled Oligopeptide Transporter YdgR, Journal of Biological Chemistry, 2018, 293, 1007-1017. doi:10.1074/jbc.M117.805960. IF = 4.106, Cit. = 6

32. Saddique, F. A., Zaib, S., SaquibJalil, S., Aslam, S., Ahmad, M., Sultan, S., Naz, H., Iqbal, M., Iqbal, J. Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N -[benzylidene or′ 1-phenylethylidene]-2-H/methyl/ benzyl/-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides, European Journal

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of Medicinal Chemistry, 2018, 143, 1373-1386. doi.org/10.1016/j.ejmech .2017.10.036. IF = 4.833, Citation = 6

33. Wasim, M., Awan, F. R., Khan, H. N., Tawab, A., Iqbal, M., Ayesha, H. Aminoacidopathies: A group of rare disorders, their prevalence, etiology and diagnosis, Biochemical Genetics, 2018, 56, 7-21. doi: 10.1007/s10528-017-9825-6. IF = 1.931, Citation = 9

34. Liaqat, M., Mahmud, T., Imran, M., Iqbal, M., Muddassar, M., Ahmad, T., Mitu, L. Synthesis, Characterization and Biological Study of a New Mannich Base, 2-[(4-fluorophenyl)(phenylamino)methyl] cyclopentanone (FPC) and its Transition Metal Complexes with Cu(II), Ni(II), Co(II), Fe(II) and Zn(II), Revista de Chimie, 2017, 68(11), 2560-2565. IF = 1.605, Citation = 1

35. Majeed, S., Iqbal, M., Iqbal, S. Z., Selamat, J., Asi, M. R. Analysis of nutritional traits and aflatoxin contamination in selected maize varieties from Pakistan, Journal of Food Protection, 2017, 80 (12), 1993-1998. doi: 10.4315/0362-028X.JFP-17-117. IF = 1.51, Citation = 2

36. Yasmin, S., Hafeez, F. Y., Mirza, M. S., Rasul, M., Arshad, H. M. I., Zubair, M., Iqbal, M. Biocontrol of bacterial leaf blight of rice and profiling of secondary metabolites produced by rhizospheric Pseudomonas aeruginosa BRp3, Frontiers in Microbiology, 2017, 8(1895), 1-23. doi: 10.3389/fmicb.2017.01895. IF = 4.259, Citation = 26

37. Chughtai, M. I., Maqbool, U., Iqbal, M., Shah, M. S., Fodey, T. Development of in-house ELISA for detection of chloramphenicol in bovine milk with subsequent confirmatory analysis by LC-MS/MS, Journal of Environmental Science and Health, Part B, 2017, 52(12), 871-879. DOI: 10.1080/03601234.2017.1361771. IF = 1.463, Cit. = 6

38. Imran, M., Habib, F., Tawab, A., Rauf, W., Rahman, M., Khan, Q. M., Asi, M. R., Iqbal, M. LC-MS/MS based method development for the analysis of florfenicol and its application to estimate relative distribution in various tissues of broiler chicken, Journal of Chromatography B, 2017, 1063, 163-173. DOI: 10.1016/j.jchromb.2017.08.029. IF = 2.813, Citation = 8

39. Salman, M., Michael, F., Ali, A., Jabbar, A., Cairns, C., Hayes, A., Rahman, M., Iqbal, M., Haque, A., Cox, A. First conjugation of Vi negative Salmonella Typhi O-specific polysaccharides with carrier proteins for preparation and evaluation of immunogenic conjugates, Journal of Immunological Methods, 2017, 450, 27-33. DOI: 10.1016/j.jim.2017.07.005. IF = 1.913, Citation = 1

40. Shah, M. A., Ullah, R., March, M. D., Shah, M. S., Ismat, F., Habib, M., Iqbal, M., Onesti, S., Rahman, M. Overexpression and characterization of the 100K protein of Fowl adenovirus-4 as an antiviral target, Virus Research, 2017, 238, 218-225. DOI:10.1016/j.virusres.2017.06.024. IF = 2.736, Citation = 3

41. Shaheen, A., Iqbal, M ., Mirza, O., Rahman, M. Structural biology meets drug resistance: An overview on multidrug resistance transporters, Journal of the Indian Institute of Science, 2017, 97(2), 165-175. doi: 10.1007/s41745-017-0032-6. IF = 0.742, Citation = 1

42. Riaz, M., Rasool, N., Iqbal, M., Tawab, A., Habib, F-E., Khan, A., Farman, M. Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (LC-ESIMS/MS) analysis of Russeliaequisetiformis extract, Bulgarian Chemical Communications, 2017, 49(2), 354 – 359. IF = 0.238, Citation = 0

43. Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, M., Mirza, O. Several hPepT1-transported drugs are substrates of the E. coli proton-coupled oligopeptide transporter YdgR, Research in Microbiology, 2017, 168 (5), 443-449. doi: 10.1016 /j.resmic.2017.01.005. IF = 2.651, Citation = 4

44. Nawaz, H., Rashid, N., Bilal, M., Saleem, M., Amin, I., Iqbal, M., Rahman, M., Knief, P., Byrne, H. J., Baig, S. M., Ahmed, M. Prediction of viral loads for diagnosis of Hepatitis C infection in human plasma samples using Raman spectroscopy coupled with Partial Least Squares Regression analysis, Journal of Raman Spectroscopy, 2017, 48 (5), 697–704. doi: 10.1002/jrs.5108. IF = 2.809, Citation = 13

45. Iram, W., Anjum, T., Iqbal, M., Ghaffar, A., Abbas, M., Structural analysis and biological toxicity of Aflatoxin B1 and B2 degradation products following detoxification by Ocimum basilicum and Cassia fistula aqueous extracts, Frontiers in Microbiology, 2016, 7: 1105, DOI: 10.3389/fmicb.2016.01105. IF = 4.259, Citation = 11

46. Ali, A., Ayesha, Hameed, S., Imran, A., Iqbal, M., Javed, M., Ivan, O. Functional characterization of a soybean growth stimulator Bradyrhizobium sp. strain SR-6 showing acylhomoserine lactone production, FEMS Microbiology Ecology, 2016, fiw115, DOI: doi: 10.1093/femsec/fiw115. IF = 4.098, Citation = 6

47. Ullah, R., Shah, M. A., Tufail, S., Ismat, F., Imran, M., Iqbal, M., Mirza, O., Rahman, M. Activity of the human

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rhinovirus 3C protease studied in various buffers, additives and detergents solutions for recombinant protein production, PLOS ONE, 2016, 11(4): e0153436, DOI: 10.1371/journal.pone.0153436. IF = 2.776, Citation = 16

48. Iram, W., Anjum, T., Iqbal, M., Ghaffar, A., Abbas, M., Structural elucidation and toxicity assessment of degraded products of aflatoxin B1 and B2 by aqueous extracts of Trachyspermumammi, Frontiers in Microbiology, 2016, 7, 346, DOI: 10.3389/fmicb.2016.00346. IF = 4.259, Citation = 15

49. Umer, M., Iqbal, M., Hepatitis C virus prevalence and genotype distribution in Pakistan: A comprehensive review of recent data, World Journal of Gastroenterology, 2016, 22 (4), 1684-1700, DOI: 10.3748/wjg.v22.i4.1684. IF = 3.411, Citation = 102

50. Salman, M., Ali, A., Jabbar, A., Sarwar, Y., Rahman, M., Iqbal, M., Haque, A. Simplest identification, o-specific polysaccharide purification and antigenic evaluation of Salmonella entericaserovarTyphi vi negative isolate, EXCLI Journal, 2015, 14:1078-1084, DOI: 10.17179/excli2015-565. IF = 2.112, Citation = 2

51. Iram, W., Anjum, T., Iqbal, M., Ghaffar, A., Abbas, M., Mass spectrometric identification and toxicity assessment of degraded products of aflatoxin B1 and B2 by Corymbiacitriodoraaqueous extracts, Scientific Reports, 2015, 5: 14672 – 14686. DOI: 10.1038/srep14672. IF = 4.011, Citation = 26

52. Abbas, W., Tariq, M., Iqbal, M., Kumar, A., Herbein, G. Eradication of HIV-1 from the macrophage reservoir: an uncertain goal? Viruses, 2015, 7, 1578-1598; doi: 10.3390/v7041578. IF = 3.811, Citation = 81

53. Shaheen, A., Thomas, W., Mirza, O. A., Ismat, F., Rita, D. Z., Haque, A., Iqbal, M., Rahman, M. Antimicrobial profiles of putative major facilitator superfamily-type multidrug resistance transporters of Salmonella Typhi studied in Escherichia coli, Journal of Infection and Chemotherapy, 2015, 5, 357-362. doi:10.1016 /j.jiac.2015.01.002. IF = 1.539, Citation = 12

54. Ali, S.; Hameed, S.; Imran, A.; Iqbal, M.; Lazarovits, G. Genetic, physiological and biochemical evidence about production of surfactin and iturin A from Bacillus sp. strain RMB7 exhibiting broad spectrum antifungal activity, Microbial Cell Factories, 2014, 13, 144-158. doi: 10.1186/s12934-014-0144-x. IF = 4.402, Citation = 40

55. Monrad, R. N.; Errey, J. C.; Barry, C. S.; Iqbal, M.; Meng, X.; Iddon, L.; Perrie, J. A.; Harding, J. R.; Wilson, I. D.; Stachulski, A. V.; Davis, B. G. Dissecting the reaction of Phase II metabolites of Ibuprofen and other NSAIDS with human plasma protein, Chemical Science, 2014, 5, 3789-3794, DOI:10.1039/c4sc01329h. IF = 9.556, Citation = 9

56. Kramer, M. E.; Halleran, D.; Rahman, M.; Iqbal, M.; Anwar, M. I.; Sabet, S.; Ackad, E.; Yousef, M. Comparative molecular dynamics simulation of hepatitis C virus NS3/4A protease (genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strains, PLOS ONE, 2014, 9, e104425. IF = 2.776, Citation = 13

57. Umer, M.; Qureshi, S. A.; Hashmi, Z. Y.; Raza, A.; Ahmad, J.; Rahman, M.; Iqbal, M. Promoter hypermethylation of Wnt pathway inhibitors in hepatitis C virus - induced multistep hepatocarcinogenesis, Virology Journal, 2014, 11, 117-126. IF = 2.464, Citation = 21

58. Sadiq, S.; Imran, M.; Hassan, M. N.; Iqbal, M.; Zafar, Y.; Hafeez, F. Y.; Potential of bacteriocinogenic Lactococcuslactis subsp. lactis inhabiting low pH vegetables producing nisin variants, LWT Food Science and Technology, 2014, 59, 204-210. IF = 3.714, Citation = 17

59. Jabbar, A.; Ali, A.; Tawab, A.; Haque, A.; Iqbal, M. Fatty acid profiling of lipid A isolated from indigenous Salmonella Typhi strain by Gas Chromatography–Mass Spectrometry, Journal of The Chemical Society of Pakistan, 2014, 36, 140-149. IF = 0.393, Citation = 2

60. Iram, N.; Shah, M. S.; Ismat, F.; Habib, M.; Iqbal, M.; Hasnain, S. S.; Rahman, M. Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies, Applied Microbiology and Biotechnology, 2014, 98, 1691-1701. IF = 3.67, Citation = 27

61. Qureshi, H.; Ali, S. S.; Iqbal, M.; Siddiqui, A. A.; Khan, N. A.; Hamid, S. S. Aflatoxins and hepatitis B, C viral associated hepatocarcinogenesis, Journal of Cell Science and Therapy, 2014, 5, 179-185, doi: 10.4172/2157-7013.1000179. IF = 1.16, Citation = 4

62. Qureshi, H., Hamid, S. S., Ali, S. S., Anwar, J., Iqbal, M., Khan, N. A. Is Aflatoxin B1 a biomarker for pathogenic potential of Aspergillus flavus? Journal of Cell Science and Therapy, 2014, 5, 188-193, doi: 10.4172/2157-7013.1000188. IF = 1.16, Citation = 3

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63. Anwar, M. I.; Iqbal, M.; Yousef, M. S.; Rahman M. Over-expression and characterization of NS3 and NS5A of Hepatitis C virus genotype 3a as targets for antiviral therapies, Microbial Cell Factories, 2013, 12, 111-122. IF = 4.402, Citation = 2

64. Anwar, M. I.; Rahman, M.; Hassan, M.; Iqbal, M. Prevalence of active hepatitis C virus infections among general public in Lahore, Pakistan, Virology Journal, 2013, 10, 351-356. IF = 2.464, Citation = 43

65. Majeed, S.; Iqbal, M.; Asi, M. R.; Iqbal, S. Z. Aflatoxins and Ochratoxin A contamination in rice, corn and corn products from Punjab, Pakistan, Journal of Cereal Science, 2013, 58, 446-450. IF = 2.452, Citation = 61

66. Naveed, R,; Hussain, I.; Tawab, A.; Tariq, M.; Rahman, M.; Hameed, S.; Mahmood, M. S.; Siddique, A. B.; Iqbal, M. Antimicrobial activity of the bioactive components of essential oils from Pakistani spices against Salmonella and other multi-drug resistant bacteria, BMC Complementary and Alternative Medicine, 2013, 13, 265-275. IF = 2.479, Citation = 108

67. Raza, H. M.; Rizvi, N-E-A.; Siddiqui, H. L.; Javaid, A.; Iqbal, M. Synthesis and biological evaluation of new [1,3,4]thiadiazepino[7,6-b]quinolin-2-amines as potent anti-microbial agents, Medicinal Chemistry Research, 2013, 22, 4001-4015. IF = 1.72, Citation = 1

68. Maqsood, M. R.; Hanif, M.; Rafiq, M.; Saleem, M.; Zaib, S.; Khan, A. A.; Iqbal, M.;Iqbal , J.; Rama, N. H.; Seo, S-Y.; Lee, K-H.;Some pyridyl- and thiophenyl- substituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole derivatives as potent antibacterial, Bulletin of The Korean Chemical Society, 2012, 33, 4180-4184. IF = 0.602, Citation = 8

69. Hanif, M.; Khan, I.; Rama, N. H.; Noreen, S.; Choudhary, M. I.; Jones, P. G.; Iqbal, M. Synthesis, crystal structure and ꞵ-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1,2,4-triazole derivatives, Medicinal Chemistry Research, 2012, 21, 3885-3896. IF = 1.72, Citation = 11

70. Stachulski, A. V.; Pidathala, C.; Row, E. C.; Sharma, R.; Berry, N. G.; Iqbal, M.; Bentley, J.; Allman, S. A.; Edward, G.; Helm, A.; Hellier, J.; Korba, B. E.; Semple, J. E.; Rossignol, J.-F. Thiazolides as novel antiviral agents. II. Inhibition of hepatitis C virus replication, Journal of Medicinal Chemistry, 2011, 54, 8670-8680. IF = 6.054, Citation = 25

71. Stachulski, A. V.; Pidathala, C.; Row, E. C.; Sharma, R.; Berry, N. G.; Iqbal, M.; Bentley, J.; Allman, S. A.; Edward, G.; Helm, A.; Hellier, J.; Korba, B. E.; Semple, J. E.; Rossignol, J.-F. Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication, Journal of Medicinal Chemistry, 2011, 54, 4119-4132. IF = 6.054, Citation = 43

72. Johnson, C. H.; Karlsson, E. S.; Sarda, S.; Iddon, L.; Iqbal, M.; Meng, X.; Harding, J. R.; Stachulski, A. V.; Nicholson, J. K.; Lindon, J. K.; Wilson, I. D.; Lindon, J. C. High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma, Rapid Communications in Mass Spectrometry, 2010, 24, 3043-305. IF = 2.045, Citation = 8

73. Johnson, C. H., Karlsson, E.; Sarda, S.; Iddon, L.; Iqbal, M.; Meng, X.; Harding, J. R.; Stachulski, A. V.; Nicholson, J. K., Lindon, J. K.; Wilson, I. D.; Lindon, J. C. Integrated HPLC-MS and 1HNMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides, Xenobiotica, 2010, 40,9-23. IF=1.902, Citation=15

74. Berry,N. G.; Iddon, L.; Iqbal, M.; Meng, X.; Jayapal, J.; Stachulski, A. V.; Johnson, C. H.; Nicholson, J. K.; Lindon, J. C.; Harding, J. R.; Wilson, I. D. Structure-reactivity relationships for arylacetic acid 1β-O-acyl glucuronides: a paradigm for non-steroidal anti-inflammatory drug metabolism, Organic & Biomolecular Chemistry, 2009,7, 2525-2533. IF = 3.49, Citation = 20

75. Rehman, M.; Anwar, M. A.; Iqbal, M; Akhtar, K.; Khalid, A. M.; Ghauri, M. A. Bioleaching of high grade Pb-Zn ore by mesophilic and moderately thermophilic iron and sulfur oxidizers, Hydrometallurgy, 2009,97, 1-7. IF = 3.465, Citation = 21

76. Iqbal, M .; Duffy, P.; Cloughley, G.; Allan, B.; Lledo, A.; Verdaguer, X.; Riera, A.; Evans, P. The conjugate addition Peterson olefination reactions for the preparation of cross-conjugate cyclopentenone, PPAR- ligands, Organic & Biomolecular Chemistry, 2008, 6, 4649-4661. IF = 3.49, Citation = 37

77. Iqbal, M .; Evans, P.; Lledo, A.; Verdaguer, X.; Pericàs, M. A.; Riera, A.; Krischke, M.; Sinha, A. K.; Mueller, M. J. Total synthesis and biological activity of 13,14-dehydro-12-oxo-phytodienoic acids (Deoxy-J1-Phytoprostanes),

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ChemBioChem, 2005, 6, 276-280. IF = 2.641, Citation = 55

78. Iqbal, M ., Li, Y., Evans, P. Synthesis of Δ12,14-15-deoxy-PGJ1 methyl ester and epi-Δ12-15-deoxy-PGJ1, Tetrahedron, 2004, 60, 2531-2538. IF = 2.379, Citation = 41

79. Eddols, J. P., Iqbal, M., Roberts, S. M., Santoro, M. G. Preparation of optically pure cross-conjugated cyclopentenones, Tetrahedron, 2004, 60, 2539-2550. IF = 2.379, Citation = 28

80. Iqbal, M .; Evans, P.; Roberts, S. M. Synthesis of biologically important cyclopentenones, Prostaglandins Leukotrienes Essential Fatty Acids, 2004, 71, 47-48. IF = 2.864, Citation = 0

81. Iqbal, M .; Evans, P. Conjugate addition–Peterson olefination reactions: expedient routes to cross conjugated dienones, Tetrahedron Letters, 2003, 44, 5741-5745. IF = 2.259, Citation = 42

82. Iqbal, M .; Vyse, N.; Dauvergne, J.; Evans, P. Microwave promoted Pauson–Khand reactions, Tetrahedron Letters, 2002, 43, 7859-7862. IF = 2.259, Citation = 48

83. Anwar, M. A., M. Iqbal, M. A. Qamar, M. Rehman, A. M. Khalid. Determination of cuprous ions in bacterial leachates and for environmental monitoring. World Journal of Microbiology & Biotechnology, 2000, 16: 135-138. IF = 2.652, Citation = 23

INTERNATIONAL PATENTS PUBLISHED:

1- Iqbal, M.; Evans, P; Roberts, S. M. Synthetic Methods and Novel Chemical Compounds, US Patent, 2005, No. US2005107477 A1.

2- Iqbal, M.; Evans, P; Roberts, S. M. Cyclopentenone Derivatives, Their Preparations and use in Medicine, European Patent, 2004, No. EP1487772 A2.

3- Iqbal, M.; Evans, P; Roberts, S. M. Cyclopentenone Derivatives, Their Preparations and use in Medicine, World Wide Patent, 2003, No. WO 03/080552 A2.

4- Iqbal, M.; Evans, P; Roberts, S. M. New Synthetic Methods and Novel Chemical Compounds, Australian Patent, 2003, No. AU2003217021 A1.

5- Iqbal, M.; Evans, P; Roberts, S. M. New Synthetic Methods and Novel Chemical Compounds British Patent, 2002, No. GB0207028D D0.

BOOK PUBLISHED:

Iqbal, M.; Rahman, M.; Anwar, M. I. Hepatitis C Virus NS3, NS5A and NS5B Proteins as Drug Targets, LAMBERT Academic Publishing, 2014, ISBN: 978-3-659-63470-3.

APPLIED RESEARCH

Services:

1. LCMS and GCMS based analytical services are provided to several Pakistani Food Exporters, i. e. Rafhan Maize Products, Ltd., Faisalabad; Reem Rice Mills, Lahore; S. A. Rice Mills, Faisalabad; Bahoo Rice Mills, Okara; Al Imran Floor Mills, Rawalpindi; Food Links, Lahore; GAT Consultants Company, Lahore; Custom Department, Lahore; A. N. I. Pine Nuts Trading Company, Lahore; Deharki Sugar Mills, Ghotki, Sindh; Department of Plant Protection, Karachi.

2. Developed several validated analytical methods, which established Pakistan’s capability for the confirmatory analysis of aflatoxins and veterinary drug residues in food samples. These methods serve the basis of analytical services offered to the food exporters/local companies and significantly contributed towards the reduction of rejection rate of the Pakistani food consignment (rice, maize, nuts) in the European market.

Process Development:

3. Developed an efficient and up-scalable process to clean aflatoxins in cereals in collaboration with Agrocom Pvt, Ltd., Lahore and Rice Export Association of Pakistan (REAP).

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Products Development:

4. Developed aflatoxins binder for poultry feed in collaboration with A&K Pharmaceuticals, Faisalabad. Our detailed investigation revealed that aflatoxins binder formulation comprised of aqueous & ethanolic extracts of Eucalyptus citriodora leaves, milk thistle, baker yeast and bentonite clay, gave excellent results (>95% aflatoxins binding activity at 100µg/Kg concentration). This formulation exhibits comparable efficiency & may replace the imported aflatoxins binder product (Fixar® by Bentoli).

5. Developed the laboratory scale whole cell and conjugate vaccine candidates against Pasteurella multocida and Salmonella Typhi, respectively.

Feasibility Studies:

Completed feasibility about bioleachability of Saindak Copper ore

6. Khalid, A. M., Iqbal, M., Shemsi, A. M., Ghauri, M. A., Anwar, M . A. and Malik, K. A. 1996. Microbial leaching of low grade Saindak ore. Final Report Submitted to Saindak Metals (Pvt) Ltd. Quetta, Pakistan.

7. Khalid, A. M., Ghauri, M. A., Iqbal, M., Qamar, M. A., Shemsi, A. M., Anwar, M. A. and Malik, K. A. 1994. A technical report was submitted to Saindak Metals (Pvt) Limited, Quetta, Pakistan, on Feasibility Studies of Microbial Leaching of Low Grade Saindak Ore.

LIST OF SCHOLARS SUPERVISED AT PH. D. AND M. PHIL. / M. S. LEVELS

Sr.No. Type Title / Scholar Name Ownership Date

1 PhD Molecular identification of aminoacidopathies causing intellectual disability in children / Dr Muhammad Wasim

Co-Supervisor 23-06-2020

2 PhD Gut bacteria of animals/pests are potential source of antibacterial molecule(s) / Dr Noor Akbar/ Dr Saima Majeed

Co-Supervisor 06-02-2020

3 PhD Analysis, Inhibition and Degradation of Mycotoxins in Foodstuff / Dr Saima Majeed

1st Supervisor 06-07-2018

4 PhD Analysis of Multidrug Residues and Their Metabolites in Meat and Milk / Dr Muhammad Imran

1st Supervisor 21-05-2018

5 PhD Epigenetic Changes Involved in Hepatitis C Virus-Mediated Hepatocarcinogenesis / Dr Muhammad Umer

1st Supervisor 14-10-2015

6 PhD Structural and Functional Paradigm of Antigenic Lipopolysaccharides of Indigenous Strains of Typhoidal Pathogens / Dr Abdul Jabbar

1st Supervisor 29-08-2014

7 PhD Heterologous Expression and Characterization of Hepatitis C Virus NS3, NS5A and NS5B Proteins as Drug Targets / Dr Muhammad Ikram Anwar

1st Supervisor 19-06-2014

8 MPhil Identification of Antifungal agents against Aspergillus flavus from Microbes / Ms. Shehr Bano

1st Supervisor 19-07-2018

9 MPhil Anti-Diabetic and Hepatoprotective Potential of Mangifera Indica Cultivar Anwar Ratol and its Phytochemical Studies /Muiz Tanvir

2nd Supervisor 12-10-2017

10 MPhil Evaluation of vaccine candidates and antibiotics against Pasteurella multocida B:2 strain / Mr Mujtaba Hassan

1st Supervisor 21-07-2017

11 MPhil Purification and Characterization of 4-hydroxy-2-alkylquinoline (HAQs) Produced by Pseudomonas aeruginosa / Ms. Rashda Safdar

2nd Supervisor 11-12-2016

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12 MPhil Development and Validation of Enzyme - Linked Immunosorbent Assay for the Determination of Chloramphenicol Residues in Milk / Mr Muhammad Ismail Chughtai

1st Supervisor 22-09-2015

13 MPhil Molecular Characterization of Indigenous Pasteurella multocida Isolates / Mr Noor Akbar

1st Supervisor 28-10-2015

14 MPhil Comparative studies of bound chloramphenicol residues in various organs of rabbits and chickens at different time intervals using liquid chromatography-tandem mass spectrometry / Ms. Maria Yaqub

2nd Supervisor 21-05-2015

15 MPhil Production and Inhibition of Aflatoxins from Aspergillus flavus and Aspergillus parasiticus Fungal Species / Mr Jamrod Khan

1st Supervisor 10-01-2013

16 MPhil A soybean growth stimulator Bradyrhizobium yumnigense strain SR-6: nodule colonization, catalase enzyme activity and AHLs-profiling studies / Ms. Ayesha

2nd Supervisor 08-11-2012

17 MPhil Synthesis and Pharmacokinetic Study of Thiazolide and Salicyloylanilide Derivatives / Mr Nadeem Ahmad

2nd Supervisor 20-05-2012

18 MPhil Aflatoxins, Proximate and Tocopherol Analysis Maize Varieties by HPLC and Mass Spectrometry / Mrs Naila Rasool

1st Supervisor 28-09-2012

19 MPhil Aflatoxins and ochratoxin-A analysis in cereals by HPLC and mass spectrometry / Ms Saima Majeed

1st Supervisor 31-10-2011

LIST OF ORGANIZED /PARTICIPATED SEMINARS/WORKSHOPS/ CONFERENCES/ ADVISORY-SERVICE/SELECTION BOARDS/TRAINING AND MANAGEMENT COURSES

Sr. # Type Title Level Date

1 Organized(Chief Organizer)

How to write competitive research grant proposals for different funding agencies

National March 15 2018

1 Organized(Chief Organizer)

2nd National Training Workshop on Chromatography and Mass Spectrometry

National Oct 28 - Nov 1, 2013

2 Organized(Chief Organizer)

1st National Training Workshop on Chromatography and Mass Spectrometry,

National April 02 - 06, 2012

3 Organized(Chief Organizer)

Five Days Training Workshop titled, “LCMS, GCMS and AAS, the Powerful Techniques for the Analysis of Inorganic, Organic and Biomaterials

National 25-29th April, 2011

4 Organized(Chief Organizer)

Organized a national level conference on "Nanomedicine"

National March 30, 2010

5 Participated Advisory Committee in Biotechnology, University of Sargodha

National 07-05-2015

6 Participated Meeting of Advisory Board, Department of Chemistry, FC College University, Lahore

National 25-11-2015

7 Focal Person & Reviewer of HEC

Proposals

Serving as a Focal Person and a Reviewer of HEC proposals in the areas of Organic / Medicinal Chemistry, Pharmaceutical Sciences, Nanotechnology, Biotechnology etc

National 2011 to due date

8 Evaluation of Research Work

(External Examiner- PhD thesis)

External examiner of PhD student, Mr. Yousuf Aqeel Sharbat. thesis entitled “Encystation in A. castellanii belonging to the T4 genotype” Aga Khan University, Karachi

National 27-05-14

9 Invited Lecture Endemic and Emerging Viral Diseases of Priority in the Middle East and North Africa (MENA), at Doha, Qatar, organized by US Department of Health and Human Services

International

May 26-29, 2014

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10 Participated in International

Training Course

LCMS ion trap instrumentation with respect to basic instrument operation, including API and ion trap theory, tuning, calibration, data collection, maintenance, and general functionality of the Xcalibur software package” scheduled at Kings College London from 08-11 March 2011, organized by Thermo Fisher Scientific

International

March 08 – 11, 2011

11 Participated in International

Training Course

Development of Interviewing Skills, organized by The University of Liverpool, UK, on 4th September 2007

International

04-09-2007

12 Participated in International

Training Course

Development of Supervisory Skills, organized by The University of Liverpool, UK, on 13-14th September 2007.

International

13-14 September

200713 Passed Advanced

Training Course on Lab Management

System

Participated and Passed (with Grade A) Advanced Training Course on Lab Management System based on ISO 17025:2005 (LEAD IMPLEMENTER), organized jointly by Quality Management System and Directorate of Quality Assurance, PAEC, Islamabad,

High Quality National Training Course

25-27 Sept. 2012

14 Passed Basic Management

Course

Participated and Passed Basic Management Course, organized by Department of Communication and Management Sciences, Pakistan Engineering and Applied Sciences, Islamabad,

National Training Course

09-27 July, 2018

15 Participated and delivered several national level training courses organized ar various institutions in Pakistan over the past 10 years

16 Reviewer of International

Journals /ebooks

Served as reviewer to several international journals and also an ebook (Bioactive Natural Products), Publisher Elsevier Science Publishers - Amsterdam

CONTRIBUTION TO NIBGE/PAEC:

Development of Drug Discovery Laboratory: I have developed a high-quality Drug Discovery laboratory from scratches without involving any financial contribution by NIBGE/PAEC. The laboratory infrastructure was developed after winning several competitive international and national grants.

Establishment of High-tech Analytical Facility: A high-tech analytical facility having liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GCMS/MS) was established. These equipments are being maintained, run and their analytical services have been commercialized after developing and validating several analytical methods. These analytical services have been given to several food exporters, local companies, research institutions, PhD/MPhil students etc.

CONTRIBUTION TO OTHER ORGANIZATIONS

Focal person and reviewer of funding agencies:

Since 2013, I have been serving as a Focal Person of HEC (Medicinal Chemistry, Pharmaceutical Sciences, and Medical Biotechnology). Over 200 research proposals of HEC, several proposals of PSF and PARB have been reviewed. I have also been serving as a member of expert committee on industrial research at HEC (Technology Development Fund) and drafted /improved HEC NRPU proposal review proformas (2016).

Member of the Advisory Board and Faculty Selection Committees: I have been serving as a member of the advisory board of The Department of Chemistry, FC College University, Lahore and Biotechnology Department, University of Sargodha. Moreover. I have also served as a Technical Member of faculty selection board (for the recruitment of Asstt. Professors) at Chemistry and Biotechnology Department, University of Sargodha. Served as a technical member for the selection of Senior Scientists, in Pakistan Atomic Energy Commission.

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MANAGEMENT EXPERIENCE:

As a Group Leader I am managing & advising the following group members:

Permanent staff: Dr Waqar Rauf (Organic Chemistry, library synthesis & catalysis), Dr Moazur Rahman (Molecular Biology & Protein Chemistry), Dr Nasir Ahmad (Biochemistry & Virology), Dr Yasra Sarwar (Medical Microbiology & Veterinary Medicine), Dr Aamir Ali (Medical Microbiology & Biotechnology), Mr Abdul Tawab (Organic / Analytical Chemistry & Biotechnology), Mrs. Sadia Mahboob (Biochemistry), Mr Abdul Wahid (Analytical Chemistry, Biotechnology &

Pasteurella multocida lipopolysaccharide chemistry), Mr Fazal-e-Habib (Analytical, Organic Chemistry, LCMS, GCMS

Postdoctoral fellow, Assistant Professors on IRSIP fellowship & PhD students: Dr Muhammad Ikram Anwar (HCV protein chemistry and antiviral assay development), Dr Abdul Jabbar (Salmonella Typhi Lipopolysaccharides Chemistry), Dr Muhammad Umer (Epigenetics, HCV, Hepatocellular Carcinoma & Aflatoxins), Muhammad Imran (Analytical Chemistry, LCMS, Veterinary Drug Residues, Drugs Pharmacokinetics), Saima Majeed (Mycotoxins analysis, inhibition and degradation LCMS, GCMS), Jamrod Khan (Organic Chemistry, anti-viral and anti-parasitic agents synthesis), Noor Akbar (Pasteurella multocida conjugate vaccine development), Mahim Khan (HCV Molecular Biology, drugs screening assay development).

MEMBERSHIP OF PROFESSIONAL BODIES:

Member of The American Chemical Society (Membership No. 30176895). Member of The Chemical Society of Pakistan.

TEACHING EXPERIENCE:

Serving as a Course Coordinator “Biochemistry” for NIBGE’s MPhil Biotechnology Class (2010 – 2017). Currently, teaching 12 lectures to MPhil Biochemistry Course, 8 Lectures to MPhil and PhD classes Advance Techniques in Biotechnology Course and 4 Lectures of Genomics, Proteomics and Metabolomics course to NIBGE’s MPhil and PhD students.

Demonstrated practical classes and workshops to under graduate students at Department of Chemistry, The University of Liverpool, UK.

TECHNICAL SKILLS:

Working as an Incharge Analytical Facilities at NIBGE and has comprehensive capabilities about operation and data processing of equipments like NMR (Bruker), LCMS/MS (LTQXL, Thermo), GCMS/MS (Polaris Q with Trace GC Ultra, Thermo), LCMS/MS (TQS with Equity UPLC, Waters), LCMS/MS (API 4000 with Agilent HPLC), LCMS/MS (Triple Quadrupole, Agilent), FTIR, Atomic Absorption Spectrophotometer. Skill full in using Xcalibur, Masslinks, Mass hunter, Chem Office (ChemDraw, 3-D Draw etc), and Microsoft Office.

A four months training (2nd March to 2nd July 2013) funded by IAEA on the drugs analysis from various matrices at Chemical Surveillance Branch, Agri-food and Biosciences Institute, Belfast, Northern Ireland UK. These are the ISO 17025 accreditated, EU reference and UK national reference laboratories.

A technical training received on “LCMS ion trap instrumentation with respect to basic instrument operation, including API and ion trap theory, tuning, calibration, data collection, maintenance, and general functionality of the Xcalibur software package” scheduled at Kings College London from 08-11 March 2011, organized by Thermo Fisher Scientific.

MANAGEMENT SKILLS / COURSES ATTENDED / SCIENTIFIC TRAININGS:

Managerial and Supervisory Skills course (2007) qualified from The University of Liverpool, UK.

Effective Interviewing skills course (2007) qualified from The University of Liverpool, UK.

Qualified an advance level course (with A+ grade) on ISO17025 Laboratory Accreditation organized by Directorate of Quality Assurance (Pakistan Atomic Energy Commission, Islamabad) and Quality Management System Pvt., Ltd (October 2012).

4 Months Training Fellowship (2012) at Agri-food and Biosciences Institute, UK, funded by International

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Atomic Energy Agency (IAEA) to get training on veterinary drug residues analysis using LC-MS/MS system

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