NF-149

A New Fungicide for Control of Powdery Mildew

IR-4 Food Use Workshop

Tampa - 2007

NF-149

• NF-149 is a new fungicide for control of a wide range of powdery mildews on various crops

• New chemical discovered by Nippon Soda Co. Ltd.

• No cross resistance to existing powdery mildew products– Biochemical MOA not yet defined

• Common name: cyflufenamid

CF3

HN

OO

NF

F

NF-149

• Powdery Mildew on Grapes

NF-149

• Powdery Mildew on Apples

NF-149

• Powdery Mildew on Cucurbits

NF-149

Fig. 3 Inhibition sites of cyflufenamid on life cycle of Erysiphe graminisFig. 3 Inhibition sites of cyflufenamid on life cycle of Erysiphe graminis

conidiospore

primarygermtube

Secondarygermtube

appressorium

haustoriumformation

growth ofsecondary hypha

conidiosporeformation

haustoria development

papilla

NF-149Effect of Cyflufenamid Against Powdery Mildews on Various Crops

(greenhouse screening, minimum inhibitory concentration)

NF-149Effect of Cyflufenamid Against a Powdery Mildew Strain Resistant to

other Commercial Fungicides (greenhouse screening, minimum inhibitory concentration)

PathogenCommercial--------fungicides

SensitivityCommercial

fungicideMIC(ppm)

cyflufenamidMIC(ppm)

S < 0.1 < 0.8

R > 100 < 0.8

triflumizole S < 0.1 < 0.8

R 5 < 0.8

S 1 < 0.8

R > 100 < 0.8

thiophanate-----------methyl

Sphaerotheca ---------- cucubitae

kresoxim----------------methyl

NF-149

• Currently registered in Japan, Korea, and the several EU countries– Cereals, fruiting vegetables, pome fruit, stone fruit– Favorable toxicological, e-fate, and eco-tox profile

• Data Submission to US EPA Planned for 2008

• Initial US formulation: 10% SC

• Low Use Rate: 12.5 to 25 grams a.i./hectare(0.011 to 0.022 lb a.i./A or 1.7 to 3.4 oz form./A)

• Planned crops for the US: grapes; 3 day PHIpome fruit; 14 day PHIcucurbits; 0 day PHIstrawberries; 0 day PHI

NF-149

• Other potential US uses include: stone fruitfruiting

vegetablesleafy vegetablescole cropshopscane berriesgrainsornamentals