Immunohistochemistry Antibody Validation Report for Anti-Survivin Antibody (STJ95838)
NewInsightsintotheScreening,PromptDiagnosis,Management...
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Editorial NewInsightsintotheScreening,PromptDiagnosis,Management, and Prognosis of Breast Cancer Philippe-Richard J. Domeyer 1 and Theodoros N. Sergentanis 2 1 Hellenic Open University, Patras, Greece 2 Department of Clinical erapeutics, “Alexandra” Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece Correspondence should be addressed to Philippe-Richard J. Domeyer; [email protected] Received 2 December 2019; Accepted 2 December 2019; Published 2 January 2020 Copyright©2020Philippe-RichardJ.DomeyerandeodorosN.Sergentanis.isisanopenaccessarticledistributedunderthe CreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,provided the original work is properly cited. Breast cancer is the most common cancer in women and the second main cause of cancer death after lung cancer. It is one of the few cancers where large-scale secondary prevention (screening) programs are of proven value. e advent of new technologies and biomarkers is currently enriching our portfolio for the prompt diagnosis of breast cancer and taking steps beyond the traditional diagnostic approaches, which have been shown to be cost-effective and are credited for the decline in mortality of breast cancer. Groups at high risk for breast cancer, such as mutation carriers, require intense and clear screening guidelines. In this special issue, we intend to cover the most recent trends regarding the aspects of screening, prompt diagnosis, management, and prognosis in the field of breast cancer. e study by Η. A. Szukis et al. evaluated factors as- sociated with the initial mode of breast cancer detection in a sample of 1,322 Black women in the Women’s Circle of Health Study. History of routine screening mammogram was associated with lower odds of clinical breast exam (CBE) as the initial mode of detection; on the other hand, lower body mass index, performance of breast self-examination before diagnosis, and larger tumor size were associated with increased odds of self-detection versus screening mammogram. e paper by Y.-J. Kang et al. aimed to determine the relationship between breast density and age in the United Arab Emirates and consequently to assess if the results have implications on screening guidelines for breast cancer in this country, using a retrospective study design. e authors observed a significant inverse correlation between breast density category and age. Compared to Lebanese and Western women, the proportion of Emirati women with dense breasts was lower. M. Leenders et al. undertook a review in the Cochrane Library, Embase, and PubMed databases up to June 2019 to assess whether extensive axillary nodal involvement can be preoperatively identified or excluded in breast cancer pa- tients. After meticulous examination of the published studies, Leenders et al. portrayed the significant limitations of all current preoperative axillary imaging modalities in the identification/exclusion of extensive nodal involvement al- though negative PET/CTand negative MRI results are rather promising. e cohort study by Y. Landman et al. examined carbon monoxide diffusing capacity (DLCO) in patients with early breast cancer without preexisting lung disease, who received anthracycline- and taxane-based adjuvant dose-dense che- motherapy (DDC). After implementation of longitudinal general linear models, the results highlighted a decrease in DLCO years after DDC, especially in older patients, a finding that points to a persistent symptomatic DLCO impairment in some cases, whereas the majority of patients recover partly. e paper by W. Y.-Y. Wu et al. estimated the inde- pendent effects of the imaging biomarkers and other pre- dictors on the risk of breast cancer death, using a prospective cohort study design. e application of imaging biomarkers along with other predictors classified twelve categories of risk for breast cancer death. In particular, it was shown that mammographic tumor appearance was an independent Hindawi Journal of Oncology Volume 2020, Article ID 8597892, 2 pages https://doi.org/10.1155/2020/8597892
Transcript of NewInsightsintotheScreening,PromptDiagnosis,Management...
EditorialNew Insights into the Screening, PromptDiagnosis, Management,and Prognosis of Breast Cancer
Philippe-Richard J. Domeyer 1 and Theodoros N. Sergentanis2
1Hellenic Open University, Patras, Greece2Department of Clinical �erapeutics, “Alexandra” Hospital, Medical School, National and Kapodistrian University of Athens,Athens, Greece
Correspondence should be addressed to Philippe-Richard J. Domeyer; [email protected]
Received 2 December 2019; Accepted 2 December 2019; Published 2 January 2020
Copyright © 2020 Philippe-Richard J. Domeyer and#eodoros N. Sergentanis.#is is an open access article distributed under theCreative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in anymedium, providedthe original work is properly cited.
Breast cancer is the most common cancer in women and thesecondmain cause of cancer death after lung cancer. It is oneof the few cancers where large-scale secondary prevention(screening) programs are of proven value.#e advent of newtechnologies and biomarkers is currently enriching ourportfolio for the prompt diagnosis of breast cancer andtaking steps beyond the traditional diagnostic approaches,which have been shown to be cost-effective and are creditedfor the decline in mortality of breast cancer. Groups at highrisk for breast cancer, such as mutation carriers, requireintense and clear screening guidelines. In this special issue,we intend to cover the most recent trends regarding theaspects of screening, prompt diagnosis, management, andprognosis in the field of breast cancer.
#e study by Η. A. Szukis et al. evaluated factors as-sociated with the initial mode of breast cancer detection in asample of 1,322 Black women in the Women’s Circle ofHealth Study. History of routine screening mammogramwas associated with lower odds of clinical breast exam (CBE)as the initial mode of detection; on the other hand, lowerbody mass index, performance of breast self-examinationbefore diagnosis, and larger tumor size were associated withincreased odds of self-detection versus screeningmammogram.
#e paper by Y.-J. Kang et al. aimed to determine therelationship between breast density and age in the UnitedArab Emirates and consequently to assess if the results haveimplications on screening guidelines for breast cancer in thiscountry, using a retrospective study design. #e authorsobserved a significant inverse correlation between breast
density category and age. Compared to Lebanese andWestern women, the proportion of Emirati women withdense breasts was lower.
M. Leenders et al. undertook a review in the CochraneLibrary, Embase, and PubMed databases up to June 2019 toassess whether extensive axillary nodal involvement can bepreoperatively identified or excluded in breast cancer pa-tients. After meticulous examination of the publishedstudies, Leenders et al. portrayed the significant limitationsof all current preoperative axillary imaging modalities in theidentification/exclusion of extensive nodal involvement al-though negative PET/CTand negative MRI results are ratherpromising.
#e cohort study by Y. Landman et al. examined carbonmonoxide diffusing capacity (DLCO) in patients with earlybreast cancer without preexisting lung disease, who receivedanthracycline- and taxane-based adjuvant dose-dense che-motherapy (DDC). After implementation of longitudinalgeneral linear models, the results highlighted a decrease inDLCO years after DDC, especially in older patients, a findingthat points to a persistent symptomatic DLCO impairmentin some cases, whereas the majority of patients recoverpartly.
#e paper by W. Y.-Y. Wu et al. estimated the inde-pendent effects of the imaging biomarkers and other pre-dictors on the risk of breast cancer death, using a prospectivecohort study design. #e application of imaging biomarkersalong with other predictors classified twelve categories ofrisk for breast cancer death. In particular, it was shown thatmammographic tumor appearance was an independent
HindawiJournal of OncologyVolume 2020, Article ID 8597892, 2 pageshttps://doi.org/10.1155/2020/8597892
predictor of risk of breast cancer death, while controlling forconventional tumor attributes and treatment modalities.Furthermore, the casting type calcifications and the archi-tectural distortion were positively associated with breastcancer death risk.
#e paper by Z. Liu et al. evaluated the immunogenicactivity of TP53 mutations in promoting breast cancer. #eenrichment levels of 26 immune signatures indicating ac-tivities of diverse immune cells, functions, and pathwaysbetween TP53-mutated and TP53-wildtype BCs werecompared based on two large-scale BC multiomics datasets.It was found that almost all analyzed immune signaturesshowed significantly higher enrichment levels in TP53-mutated BCs than in TP53-wildtype BCs, and that BCimmunogenicity could be enhanced by mutant p53 viaregulation of p53-mediated pathways.
I. Susac et al. evaluated the expression and polymor-phisms in the BIRC5 gene (baculoviral IAP repeat con-taining 5), as well as the immunohistochemical expression ofthe BIRC5-encoded protein, survivin, in Croatian women.High survivin expression significantly correlated withnegative ER status and Ki-67 expression. Interestingly, theresults uncovered alleles of five BIRC5 polymorphisms(–1547C>T, –644T>C, –241C>T, 9386T>C, and9809T>C) that were associated with younger age of breastcancer onset.
Conflicts of Interest
#e editors declare that they have no conflicts of interestregarding the publication of this special issue.
Acknowledgments
We would like to express our gratitude to Professor F.Zagouri for her valuable contribution to this special issue.We are also grateful to all authors whose important workmade this special issue possible. We hope this collection ofarticles will be useful to the scientific community.
Philippe-Richard J. Domeyer�eodoros N. Sergentanis
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