Paulo Almeida

Concepts in Biochemistry

Proteins

NEW FROM GARLAND SCIENCE

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Almeida 2-79

1

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Long connection

Long connection

Long connection

Long connection

(A)

(B) (C)

Figure 2.79 Drawing the Greek key topology of a simple β-barrel.

CONTENTS

To download a detailed table of contents and chapter sample, please visit:

Proteins: Concepts in Biochemistry teaches the biochemical concepts underlying protein structure, evolution, stability, folding, and enzyme kinetics, and explains how interactions in macromolecular structures determine protein function. Intended for a one-semester course in biochemistry or biophysical chemistry with a focus on proteins, this textbook emphasizes the logic underlying biophysical chemical principles.

Problems throughout the book encourage statistical and quantitative thinking. The text is ideal for senior undergraduates, first year graduate students, and practitioners in chemistry, biochemistry, biology, and biophysics.

Almeida 6-07

Figure 6.7 Structure α-TrpS with its bound substrate, IGP, shown in black (PDB 1QOQ).

Paulo AlmeidaUniversity of North Carolina Wilmington, USA

k ≈ ku

k ≈ kf

In kfwater

In ku

In k

/s–1

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6

4

2

0

–2

–4

–6

–8

0 2 4 6 8[GuHCl] (M)

Almeida 5-34

Figure 5.34 Chevron plot of k (k = kf + ku) as a function of denaturant concentration (GuHCl).

March 2016 • Paperback • 8-1/2 x 11 432 pages • 346 illustrations978-0-8153-4502-2 • $80.00

FEATURES• Focuses on the interdisciplinary aspect of protein biophysical chemistry,

offering a quantitative description of proteins that integrates concepts from organic chemistry, physical chemistry, and biology.

• Written in consideration of the requirements for an ACS-certified BS degree in chemistry, the text meets the recommendations of the American Chemical Society, National Research Council, and National Science Foundation to feature more biochemistry and quantitative study in the life sciences.

• Each chapter ends with problem sets, with a complete solutions manual available to instructors, and key references for further reading.

www.garlandscience.com/product/isbn/9780815345022

• Artwork available in PowerPoint® and JPEG formats.• Solutions to end-of-chapter problem sets.

INSTRUCTOR RESOURCES

EXAMINATION COPIESTo apply for an examination copy for courseadoption consideration, please visit ourwebsite, garlandscience.com, or write to usat science@garland.com with the followinginformation:

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Examination copies are sent at our discretion.

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Paulo Almeida is a Professor in the Department of Chemistry and Biochemistry at the University of North Carolina Wilmington. His research seeks to understand the mechanism of antimicrobial, cytolytic peptides, and cell-penetrating peptides, as well as study domain formation in lipid membranes in terms of the molecular interactions between lipids, and how they are influenced by proteins and peptides bound or incorporated into the membrane.

ABOUT THE AUTHOR

1. Statistical Thermodynamics of Biological Molecules

2. Protein Structure3. Evolution of Protein Sequence

and Structure4. Protein Stability5. Protein Folding6. Binding, Allostery, and

Cooperativity

7. Enzyme KineticsAppendix A. Calculation of the Excess Heat Capacity Curve of Protein Thermal DenaturationAppendix B. Calculation of the Average Helicity from the Partition FunctionAppendix C. Solution of Rate Equations for Two-State System

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