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27 J Infect Dis Antirnicrob Agents

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4. m1~'lb~eJ~lb~3J 'V'lU1~tieJU.-rr1.,jtJeJtJ~eJ1EltJ~::;5.5.

b~eJ~'V'lU~El P. aeruginosa, P. maltophilia, Candida bb~:: b~El11.

3. ll"lUfl11H'l1Hflal1fl imipenem/cilastatin 1~fu

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28 ::'In'" 5 01 u~un"; 1 ..11,... JJ.fI.-JJ.fl. 2531

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epidermidis.

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2. lun111n'l:l1hfl~W1b~€lluh -J'V'lrJ1U1G'l

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3. l.h~iiYlim'WmtlUflqlJl~tl'lltl.:Jsulbactamlampicillin

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29 J Infect Dis Antimicrob Agents Vol 5 No.1 Jan. - Mar. 1988

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~1tJ bb~~tJm1~'il~1'\.t1'\.thh~'\.t porins ~ outer membrane 1. b~€Jm.Jn~1Jbbm1JU1m11JYl.J MRSA, tJnb1'U,

'lJ€J.Jb~€J. m1bn'ilm1~€JtJ11'\.tn~1Jfl11'\.t Streptococcus bbYl'IJ'I1n speciesl~'\.t1l~bn'ilil ~€J WUYln '] , , m1bbtJ.JWf1'lJ€J.Jb~€J 107 bb~~ 1(jl f1~.J. i.llwu plasmid 1'\.tfll1~€J 2. S. jaecalis.

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conjugation i.~~1tJ. 1. Streptococcus

2. tl·nhh~i1l1imvtf1TH116UtHnJI~6'1l6-:1lJl. Iim""'II'iU\\.I- 2. obligate anaerobes. " ~ q 'fl' 1 .. '" flftltl~'i 1U\~vt}l'\l6-:1lJl tIln~1J uoroqumo one 6jJ'.J1J nor 0- 3. Ureaplasma urealyticum.

xacin, pefloxacin, ofloxacin, enoxacin bb~~ ciprofloxacin U1:;ffYl~1llW~fl Mycobacterium bb~~ Chlamydia

dJ'\.tn~1J 6-fluoro-7-piperazino-4-quinolone. tJ'lnl,t~'1JUIii ~u,nutIlLb~~:;Wf1. (1iI111.J~ 1)

Yll.J1.h~ffYl~11lW~fl b~fl bb ~~ bllff'll1l ~'\.tf!lff 1iI1 b"'\.tn11tlln ~1Jfl11'\.t- brimU1tJUbYitJUU1:; ffYl~ 1llW'lJfl.JtJ11u,n ~1J fluoroqui­, h'\.tbrhe1'u,3jm'il nalidixic dJU,tJl~U,bbUU. nolone l'iltJ1ifll MIC90 WU11 ciprofloxacin ijU1~ffYl~1llW

if7I1m::iinfffl1'fW!iU#a'llfNlJl £Jln~1J fluoroquinolone ff.J~ff'il. ff1U, norfloxacin, ofloxacin bb~~ pefloxicin 3j ~ ,

ij1.h:;ffYl~ 11lW~1Jln~m~fl1u,n~1J U1~ffYl~1llw1n~b~tJ.Jnu, bb~:; enoxacin ijU1~ffYl~1llW~€JtJn11, ~ ..

1. Enterobacteriaceae tJlIil1flU,. ./ 0>" V -r. 0;( ,

if'iIJflfIlifJJ1JWfJ7'lJ1iIn'llfJt/lJf17ifm tJln ~1J fluoroqui­2. Enteric pathogen . , , ~ .., 1 nolone b{Ju,tIl~'IJ1vmi.~Yll.JUln. 3jtJl 2 Wf11'\.tn~1J~ijm1~11Vi'3. b'll€JYl1.JbbYl.Jbbm1J~Uparaco on ,

4. b~flYl1.JLbrl.JLbm1J~'IJ non-fermentative 111J~.J dJU,LbU'lJU'ilb'JJ1'1?)~fl'ilb~€J'il~1tJ ~fl pefloxacin bb~~ ciprofloxa­

P. aeruginosa. cin. 1U,fll1 U1v\11Yll.JUlntJln ~1Jd1l:; t1n'il'iloJi1Ji.~ b111Jl nn11 I 1 \J \l I

5. Neisseria species 90 'lJfl.J'lJ'\.tl'ilYiu1V\111l~t1n'il'iloJi1J1lltJ1fltJ~:; 1u,n~1i.llbnu, 1 'il'111J.J. ~ ~

6. H. injluenzae. 1:;WfU'lJ€J.JtIl1 U,b~flm~ ~'il ~.Jbrifl'IJ1V\11V\ ~.Jmm1 til ciproflo­

~l'iH~ 1 l.h~a'YInmW'Iltl-:lUl fluoroquinolone I?itl~~~W (MICso/MIC9o)

Organism Norfloxacin Pefloxacin Ofloxacin Ciprofloxacin Enoxacin

S. aureus 0.8/6.3 0.25/0.5 0.4/0.4 0.5/1 0.8/3.1 S. epidermidis 1.6/3.1 0.5/0.5 0.4/0.8 0.25/0.25 1.6/1.3 S. pyogenes 1.6/6.3 1.6/3.1 0.5/2.0 6.3/12 S. faecalis 0.8/12 0.8/1.6 1/2 12/12 S. viridans 4.0/16 2/2 1/2 16/32 S. pneumoniae 2.0/4.0 2/2 0.5/1 8/16 N. meningitidis < .12/< .12 N. gonorrhoeae 0.03/0.06 .02/.06 .01/.01 .12/.25 H. in[luenzae 0.02/0.02 0.03/.06 .4/1.6 < .02/.02 .05/.05 E. coli 0.06/0.12 0.13/.25 .05/.2 .02/.03 .1/.4 K. pneumoniae 0.2/1.6 0.2/2 .1/.2 < .12/< .12 .4/3.1 A. hydrophila < 0.02/0.03 < .1/<.1 < .01/.01 .01/.02 Salmonella .03/.06 .12/1 .13/.5 .03/.03 .1/.2 Shigella .03/.03 .06/.06 < .1/<.1 .02/.02 .1/.2 E. cloacae .1/.4 .06/1 <.12/.12 .2/.4 P. vulgan's .1/.4 .5/2 .06/.13 < .12/< .12 .4/.16 P. aeruginosa .8/3.1 1/2 .8/3.1 .25/ .5 1/2 Peptococcus 4/8 2/4 .25/2.0 4/8 B. fragilis 64/128 8/16 1.6/6.3 .5/2 25/50 C tracomatis 16/16 1/4 1/1 8/16 U. urealyticum 16/32 4/8 16/32 32/64

J Infect Dis Antimicrob Agents Vol. 5 No.1 Jan. - Mar. 1988 31

<i ffo ,d • \lIUHfl2 If) 'If"Cl'Ufllff\?l'j'lHl~Ulf)~1J fluoroqumolone

Drug Dose Route Cmax Blister fluid (% serum) AVC (ug. h/ml) Excretion (% urine) 'lli (hr)

Norflox 400 Oral 1.5 67 5.6 28 3.4 Peflox 400 Oral 3.8 46 ­ 54 10

400 l.V. 4.2 54 11 11 Oflox 600 Oral 11 47 58 7 Cipro 500 Oral 2-3 61 10 -19 3.41 3-5

100 Oral 0.5 2 4.1 100 l.V. 2.1 28 2.8 76 4

Enox 600 Oral 3.7 81 29 67 6.2

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32 :!<In" 5 "uvun" 1 JUl.-JUl... 253111...

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v ,

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Vol. 5 No.1 Jan. - Mar. 1988 33

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Coumermycin 0 5 High

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~

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60-87. IrlBH1l3JffU rifampicin e1'il11m1V11£J"iJ:;I1Ju1B£Jt'l:; 133-50.

35 J Infect Dis Antimicrob Agents

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Vol. 5 No.1 Jan. -Mar. 1988

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