Neurotransmission of signals
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Transcript of Neurotransmission of signals
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–Describe the steps in neurotransmission. – Describe the ionic basis for
neurotransmitter release.–List the major neurotransmitters and
describe their mode of action.–Describe the basic organization of the
nervous system.
Neurotransmission of signals
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Conduction of Action Potentials
Figure 8-14a: Conduction of action potentials
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Mechanism of Vg Na+ channels
Figure 8-10: Model of the voltage-gated channel Na+
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Neurocrines
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Neurocrines
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Possible mechanisms of NT action
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Neurotransmitters and Receptors
• ACh receptor (cholinergic) – nicotinic
– muscarinic
• NE and E receptor (adrenergic) 1 and 2 (alpha)
1 and 2 (beta)
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Acetylcholine
• nicotinic receptor … is a Na+ / K+channel
• muscarinic receptor … is a G-protein coupled receptor
that links to 2nd messenger; five known forms
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• http://www.blackwellscience.com/matthews/neurotrans.html
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Acetylcholine synthesis
Figure 8-21: Synthesis and recycling of acetylcholine at the synapse
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Norepinephrine/Epinephrine• adrenergic receptors, alpha and beta
… are G-protein coupled receptors, linked to 2nd messengers
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–Describe the basic organization of the nervous system.
–List the steps in neurotransmission.
Neurotransmission of signals
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Organization of the Nervous System
Text Figure 8-1
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