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  • Neuroscience Paris Seine Director H. Chneiweiss

    UPMC Institut de Biologie Paris Seine

    Gathers 15 research teams in Neurosciences 100 permanent position (Researchers, Assistant Professors, Professors, Engineers and

    Technicians) More than 70 students (Masters, Thesis, Post-doctorants)

  • CdF

    ENS

    UPMC

    IFM

    IdV

    ICM

    Institute of Biology Neuroscience Paris Seine

    Neuroscience Paris Seine Director H. Chneiweiss

    Embedded into a rich Neuroscience environment in Paris

    2700 m2 available space, 1500m2 already refurbished, 70 m2 minimal space per team

  • Neuroscience Paris Seine

    To understand the brain, to treat its diseases and to improve its abilities.

  • Neuroscience Paris Seine

    Complementarity of scientific questions, skills and technological approaches among teams

    An integrated approach: From molecular & cellular networks to physiology & pathology

    Continuum from fundamental research to preclinical models

  • Transversal axis 1 (5 teams) Neural Development, Plasticity and Regeneration

    Neuroscience Paris Seine

    d~5-8 m

    Plasticity of Neural networks Stem cell niche CNS/PNS microenvironment Spinal Cord

  • Transversal axis 2 (7 teams) Dynamics of Neuronal Networks and Cognitive Processes

    Neuroscience Paris Seine

    Neurotransmitters Sensory processing Neurovascular coupling Energy supply Sleep Decision making Depression - Anxiety Autism - Schizophrenia Drug abuse - Absence Epilepsy Alzheimers disease

  • Transversal axis 3 (3 teams) Cellular and molecular basis of Neuroadaptation

    Neuroscience Paris Seine

    Long-term adaptation Epigenetics Nuclear receptors Reproduction Addiction Stress

  • Examples of shared methodological approaches

    Molecular and cellular biology epigenetics proteomics metabolism

    Cell cultures neurons glial cells - human neural stem cells and glioma stem cells

    Imaging at cell and whole brain levels - two-photon Ca2+ imaging - in vivo functional imaging

  • Shared methodological approaches

    In vitro electrophysiology unitary and multiunitary in brain slices

    In vivo electrophysiology Anesthetized or freely moving mice in enriched environments optogenetics

    Animal models

    Behavioral tests and phenotyping platforms

  • Development of micro-patterning of substrate molecules for cell culture

    d~5-8 m

    Nano-eNablerTM System

    FRM & biotech

    Virtual reality treadmill for mouse

    Labex Biologie Psychiatrique

    Bioluminescence

    Examples of technological developments :

  • Neuroscience Paris Seine

    Complementarity of scientific questions, skills and technological approaches :

    Common facilities of the Neuroscience Paris Seine unit:

    Culture rooms (P2/L2 100 m2)

    A2/L2 (B6 25m2)

    Rooms for deep freezers and machines 48 m2

    Histology (cryostat) 28 m2

    Microscopy 28 m2

    Behavioral platforms - 250 m2

    Stabulation rooms for animals under experimentation 28 m2

  • Neuroscience Paris Seine scientific animation

    Weekly data club

    Weekly seminar on Epistemology, History and Ethics in Neurosciences: Jean-Gael Barbara

    Weekly scientific seminars of distinguished visitors

    General rehearsals: Prior competitions or diploma defences.

    Strong training support: Internal and external Workshops opened to scientists, technicians, engineers & administrative staff

    Science and Society: Brain Awareness week Ecole des neurosciences de Paris (ENP) Neuroethics

  • National/International positioning of Neuroscience Paris Seine

    2 groups with teams both at UPMC and McGill University, Montreal CANADA

    2 coop with University of British Columbia, Vancouver CANADA

    University of Rio de Janeiro (CAPES/COFECUB program) BRAZIL

    ANR International University Hong-Kong, CHINA

    Paris Excellence Network : ENP (9)

    Labex (10)

    European associated laboratory Cardiff university, CNRS UNITED KINGDOM

    University of Hsselt Tournesol program BELGIUM

  • More than 130 papers published from sept 2013 to sept 2014 12 papers co-authored by 2 or more teams 2 registered patents (+ 1 pending) 1 start-up (Melkin-Pharmaceuticals) (+ on-going projects)

    Neuroscience Paris Seine Metrics

    IF> 12 : Science (2), Neuron (3), Molecular Psychiatry (5), PLoS Genet (3), Nat. Neurosci., Nat. Genet., Nat. Medicine, Nat. Commun., Blood, Biomaterials, Faseb J., Am. J. Hum. Genet. IF>7 : J. Neurosci. (9), Biol. Psy (4), Cereb Cortex (3), Embo Rep. (2), PNAS, Cell Death. Diff., Stem Cells.

  • Neuroscience Paris Seine Unit

    Thank you for your attention Herv Chneiweiss

  • DEPARTEMENT OF NEUROSCIENCES Head : CHNEIWEISS Herv 15 Research Groups

    Group 1 Genetics of Autism BETANCUR Catalina (DR2, INSERM) DELABY Elsa (DOC) PILORGE Marion (DOC) XXX (MCF, UPMC)

    Group 2 Neuronal Signaling and Gene Regulation CABOCHE Jocelyne (DR1, CNRS) VANHOUTTE Peter (CR1, CNRS) BETUING Sandrine (MCF, Chaire UPMC) CAHILL Emma (DOC) HECK Nicolas (MCF, UPMC) KAPPES Vincent (TCH, CNRS) MOUMNE Lara (POST-DOC) PAGES Christiane (TCH, UPMC) SALERY Marine (DOC)

    Group 3 Cortical Networks & Neurovascular Coupling LAMBOLEZ Bertrand (DR2, INSERM) CAULI Bruno (CR1, CNRS) BERGEL Antoine (DOC) BONNOT Agns (MCF, UPMC) COHEN Ivan (CR1 INSERM) HAY Audrey (DOC) HEPP Rgine (MCF, UPMC) LACROIX Alexandre (DOC) NOMURA Shinobu (DOC) SIEU Lim Anna (DOC) TRICOIRE Ludovic (CR2, CNRS)

    Group 4 Glial Plasticity CHNEIWEISS Herv (DR1, CNRS) JUNIER Marie-Pierre (DR2, INSERM) DEVAUX Bertrand (PUPH, UPD) DIAS-MORAIS Amlie (TCH, INSERM) LIPECKA Joana (AI, INSERM) El-HABR Elias (POST-DOC) BOGEAS Alexandra (DOC) DiUBOIS Gustavo (DOC)

    Group 5 Normal and Pathologic Glutamatergic Systems EL MESTIKAWY Salah (DR1, CNRS) BERNARD Vronique (CR1, INSERM) DAUMAS Stphanie (MCF, UPMC) FABRE Vronique (CR1, INSERM) LAMBERT Lisa (DOC) MIOT Stphanie (DOC) POIREL Odile (TCH, INSERM) RAMET Lauriane (DOC) SAKAE Diana Yae (DOC)

    Group 6 Neurophysiology and Behavior FAURE Philippe (DR2, CNRS) DIDIENNE Steve (DOC) MOREL Carole (DOC) MOUROT Alexandre (CR1, INSERM) NAUDE Jermie (POST-DOC) TOLU Stfania (POST-DOC) VALVERDE Sbastien (DOC)

    Group 7 Pathophysiology of Psychiatric Disorders GIROS Bruno (DR1, CNRS) BECKER Christel (MCF) BENOLIEL Jean-Jacques (MCUPHHC, UPMC) CAMUS Franoise (AI, UPMC) COUROUSSE Thomas (DOC) DE GOIS Stphanie (IR2, CNRS) ERDOZAIN Amaia Maite (POST-DOC) FARLEY Sverine (POST-DOC) GAUTRON Sophie (CR1, INSERM) GRANNEC Gael (TCH, UPMC) LOUIS Franck (TCH, INSERM) MORICE Elise (MCF) SEVOZ-COUCHE Caroline (CR1 INSERM) TZAVARA Eleni (DR2, INSERM) VIALOU Vincent (CR2, INSERM)

    Group 8 Development and Degeneration of Spinal Motor Neurons HAZAN Jamil (CR1, CNRS) FASSIER Coralie (CR2 INSERM) JARDIN Nicolas (DOC) TEN MARTIN Daniel (DOC)

    Group 9 Neuronal Networks and Physiophatological Rhythms LERESCHE Nathalie (DR1, CNRS) LAMBERT Rgis (PR1, UPMC) BESSAIH Thomas (MCF, UPMC) BOUTOURLINSKY Katia (IE2, CNRS) CHAUSSON Patrick (DOC) PIGEAT Romain (DOC)

    Group 10 Development of the Spinal Cord Organization LEGENDRE Pascal (DR2, INSERM) MANGIN Jean-Marie (CR1, INSERM) BULLIER Erika (AI, UPMC) CZARNECKI Antony (MCF, UPMC) LE BRAS Barbara (MCF, UPMC) LE CORRONC Herv (MCF, U Angers) MOUFFLE Christine (TCH, CNRS) RIGATO Chiara (DOC) SWINNEN Nina (DOC)

    Group 11 Neuroplasticity of Reproductive Behaviors MHAOUTY-KODJA Sakina (DR2, CNRS) ALBAC Christelle (AI, CDD/CNRS) CLARISSE Marie-Luce (DOC) HARDIN-POUZET Hlne (PR1, UPMC) MESSENT Valrie (MCF, UPMC) NAUL Lydie (DOC, CDD/CNRS) PARMENTIER Caroline (TCH, UPMC) PICOT Marie (POST-DOC)

    Group 12 Axonal Growth and Regeneration NOTHIAS Fathia (DR2, CNRS) BENASSY Marie-Nolle (AI, UPMC) CHEDLY Jamila (DOC) MILBRETA Ulla (DOC) SOARES Sylvia (MCF, UPMC) VINCENSINI Laetitia (MCF, UPMC) VON BOXBERG Ysander (CR1, CNRS)

    Group 15 Gene Expression, Neurophysiology and Behavior TRONCHE Franois (DR2, CNRS) BARIK Jacques (MCF, UPMC) BENECKE Arndt (CR1, CNRS) KARAKI Samah (POST-DOC) MAATOUK Layal (DOC) TASSIN Jean-Pol (DR Emerite, INSERM) VYAS Sheela (CR1, INSERM) WONG Alana (DOC)

    Group 14 Development & Plasticity of Neural Networks TREMBLEAU Alain (PRCE, UPMC) CAILLE Isabelle (MCF UPMC) DAROLES Laura (DOC) DUBACQ Caroline (MCF UPMC) DUSART Isabelle (DR2, CNRS, join in 2014) FOUQUET Coralie (AI, CNRS) GRIBAUDO Simona (POST-DOC) MAUCUER Alexandre (CR1 INSERM, join in 2014) MOREL Marie-Pierre (TCH, INSERM, join in 2014) SMIT Daniel (DOC) VILLALPANDO Sabrina (POST-DOC)

    Group 13 Memory, Navigation and Aging RONDI-REIG Laure (DR2, CNRS) BABAYAN Bndicte (DOC) DE LAVILLEON Gatan (DOC) LEFORT Julie (DOC) OBIANG Pauline (POST-DOC) PARADIS Anne-Lise (CR1, CNRS) ROCHEFORT Christelle (MCF, UPMC) WATILLIAUX Aurlie (IE2, CNRS) ZHANG Lu (POST-DOC)

    Mis jour le, 20/09/2012

    ADMINISTRATION COMMON SERVICE DEJANCOURT Catherine (TCN, CNRS) CANNYA Vidji (AGT, UPMC) DIAMANT-CABARUS Joanna (AJT, UPMC) COULIBALY Mariatou (AJT UPMC) FAIVRE- WEBER Sylvie (IE, CNRS) HANNESSE Bernadette (AGT, UPMC) GRARD Catherine (TCE, CNRS) HANOUEL Marie-Jo (AJT, UPMC) HOAREAU Sonia (AI, UPMC) KHYAR Najat (TN, Inserm) REBECCHI Barbara (TS, Inserm) MARIE Jean-Luc (AJT, UPMC) PONTIFICE Maria (AJT, UPMC) TURQUET Maryse (AJT, CNRS)

    ATTACHES A LA DIRECTION

    Directeur de l'UFR 927 Daniel VERGE (PR, UPMC)

    Ep