Neuronal properties of the Dopaminergic neuron, H-cell

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Dopamine ple, Ddc, VMAT, DAT Neuropeptide receptor: NPFR1 Serotonin receptor: 5-HT1A Glutamate Receptor: Glu-RI. Neuronal properties of the Dopaminergic neuron, H-cell. H-cell. tup regulates dopamine biosynthetic and transport genes. BH1. 5-HT1A. CG31757. SoxN. D. Glu-RI. Elav. - PowerPoint PPT Presentation

Transcript of Neuronal properties of the Dopaminergic neuron, H-cell

Page 1: Neuronal properties of the Dopaminergic neuron, H-cell
Page 2: Neuronal properties of the Dopaminergic neuron, H-cell

Neuronal properties of the Dopaminergic neuron, H-cell

Dopamine ple, Ddc, VMAT, DAT

Neuropeptide receptor: NPFR1 Serotonin receptor: 5-HT1A Glutamate Receptor: Glu-RI

H-cell

Page 3: Neuronal properties of the Dopaminergic neuron, H-cell

tup regulates dopamine biosynthetic and transport genes

pdm2nub

tup

SoxN

D

BH1

HGTX

esg

sim

Pros

Ddc

zfh1

wor

ple

NPFR1

DAT

Glu-RI

5-HT1A

VMAT

Elav

CG31757

SNF4A

Page 4: Neuronal properties of the Dopaminergic neuron, H-cell

tup expression begins late s11

Page 5: Neuronal properties of the Dopaminergic neuron, H-cell

Proteins involved in catacholamine synthesis

Tyrosine L-DOPA Dopamine

TH (ple)

VMAT

Ddc

Catsup

GTP

BH4

GTPCH (Pu)

DAT

Catsup

Page 6: Neuronal properties of the Dopaminergic neuron, H-cell

Ddc is down regulated in tup mutants

Page 7: Neuronal properties of the Dopaminergic neuron, H-cell

Ddc Ab staining

Ddc

Ddc

Ddc/GFP

Ddc/GFP

Page 8: Neuronal properties of the Dopaminergic neuron, H-cell

Ddc enhancer analysis

Grainyhead binds element IDrifter binds Cf1

Page 9: Neuronal properties of the Dopaminergic neuron, H-cell

tup represses NPFR1 expression in abdominal segments

Page 10: Neuronal properties of the Dopaminergic neuron, H-cell

Mapping Antp midline expression

Antp is expressed in mVUMs in T1

Page 11: Neuronal properties of the Dopaminergic neuron, H-cell

Gene regulatory networks in the H-cell

pdm2nub

tup

SoxN

ac/sc

D

BH1

HGTX

esg

sim

Pros

Ddc

zfh1

wor

ple

NPFR1

DAT

Glu-RI

5-HT1A

VMAT

Elav

CG31757

SNF4A


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